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https://www.readbyqxmd.com/read/29335925/germline-deleterious-mutations-in-genes-other-than-brca2-are-infrequent-in-male-breast-cancer
#1
Florentia Fostira, Emmanouil Saloustros, Paraskevi Apostolou, Andromahi Vagena, Despoina Kalfakakou, Davide Mauri, Dimitrios Tryfonopoulos, Vassileios Georgoulias, Drakoulis Yannoukakos, Georgios Fountzilas, Irene Konstantopoulou
PURPOSE: Male breast cancer (MBC) is a rare cancer entity, with mutations in BRCA1 and BRCA2 genes accounting for ~ 10% of patients. Multiple-gene sequencing has already entered clinical practice for female breast cancer, whereas the performance of panel testing in MBC has not been studied extensively. Therefore, the aim of this study was to evaluate the clinical utility of panel testing for MBC, by the largest gene panel used so far, through investigation of patients deriving from a population with known founder effects...
January 15, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29327131/renal-vein-thrombosis-complicating-severe-acute-pyelonephritis-with-renal-abscesses-and-associated-bacteraemia-caused-by-extended-spectrum-beta-lactamase-producing-escherichia-coli
#2
Stelios F Assimakopoulos, Pantelis Kraniotis, Charalambos Gogos, Markos Marangos
Acute pyelonephritis might be complicated by the formation of renal and perirenal abscesses and very rarely by renal vein thrombosis, which is a life-threatening condition. The main causative agents of acute pyelonephritis are enterobacteriaceae with the incidence of extended-spectrum beta-lactamase (ESBL)-producing strains increasing worldwide. We present the case of a 71-year-old Greek man with history of diabetes mellitus and recent hospitalization, who suffered from severe pyelonephritis with renal abscesses formation and associated bacteraemia caused by ESBL-producing Escherichia coli, complicated by extensive thrombosis of the ipsilateral renal vein and its branches, protruding also in the inferior venal cava...
January 11, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29317314/phi-in-physiology-psychology-and-biomechanics-the-golden-ratio-between-myth-and-science
#3
REVIEW
Marco Iosa, Giovanni Morone, Stefano Paolucci
In recent years, there has been a renewed interest in the use of the so-called golden ratio (Phi, ϕ), an irrational number with fractal properties, used in artworks since V century BC. and now for modelling complex biological structures and functions. This number, in fact, recursively pops-up in human history, from Ancient Greeks to Renaissance, and to contemporary scientific studies. Nevertheless, recent scientific results often fall between two extremes: those of a priori sceptic researchers accusing the artificial emergence of ϕ in many studies, and those of researchers that find a mystic meaning in the presence of ϕ in human physiology...
January 6, 2018: Bio Systems
https://www.readbyqxmd.com/read/29313095/apollonius-of-citium-first-century-bc-and-his-work-on-the-treatment-of-joint-dislocations
#4
Konstantinos Markatos, Demetrios Korres, Demetrios Chytas, Marianna Karamanou, Ioannis Sourlas, Georgios Androutsos, Andreas Mavrogenis
The purpose of this study was to summarise the life and work of the Cypriot physician Apollonius of Citium (first century BC). His overall work on medicine is presented, and special emphasis is given to his work on the treatment of joint dislocations. The most famous work of Apollonius is Treatise On Joints, which was preserved on the whole in a manuscript of the tenth century AD. In that manuscript, Apollonius is obviously influenced by the Hippocratic Corpus of Medicine. His description, diagnostic methods and reduction techniques are all based on those described by Hippocrates in his work "On Joints"...
January 8, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29288555/the-focused-history-and-physical-circa-100-bce
#5
Katherine D van Schaik
When modern physicians reflect on 'ancient medicine' or 'Greek medicine,' they typically think of Hippocrates and Galen. Few know of the raging, centuries-long intellectual debates among physicians about what exactly mattered in the treatment of illness, or about a group of physicians whose pattern-based, systematized approach to health and disease was a forerunner of how today's emergency medicine physicians evaluate and treat their patients.Methodist physicians (c. 100 BCE to 500 CE, active mostly in Rome but present throughout the Mediterranean world) were named after their "method" of healing...
December 30, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29245459/taxonomic-review-of-the-genus-i-euboeus-s-str-i-boieldieu-1865-i-probaticus-i-i-s-str-i-seidlitz-1896-syn-n-coleoptera-tenebrionidae
#6
M V Nabozhenko, N B Nikitsky, B Keskin
The taxonomic history and position of the genera Euboeus and Probaticus within the tribe Helopini are discussed. A new synonymy, based on morphological characters is established: Euboeus Boieldieu, 1865 = Probaticus (s. str.) Seidlitz, 1896, syn. n. As a result, 67 new combinations (from Probaticus to Euboeus) are estabished for all species formerly placed in Probaticus. A review of Euboeus s. str. with four species (Balkanian-Anatolian E. mimonti Boieldieu, 1865 and E. tentyrioides (Küster, 1851), Greek E...
November 30, 2017: Zootaxa
https://www.readbyqxmd.com/read/29236893/pan-syrinx-and-syringomyelia
#7
Leonardo Palacios-Sánchez, Juan Sebastián Botero-Meneses, María Camila Vélez-Flórez
Many myths and legends have had a deep influence on modern language, and on modern medical vernacular. The terms "syrinx" and "panic"are two of the most characteristic examples and their use in neurology and other specialties is well known. This article reviews the history of these words in Greek mythology and their use in modern medicine. It is known by very few that clinical symptoms or conditions, such as syringomyelia and panic attacks, have a mythological origin in their definition and naming.
December 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29233723/the-different-faces-of-the-p-a53t-alpha-synuclein-mutation-a-screening-of-greek-patients-with-parkinsonism-and-or-dementia
#8
Marianthi Breza, Georgios Koutsis, Georgia Karadima, Constantin Potagas, Chrisoula Kartanou, Sokratis G Papageorgiou, George P Paraskevas, Elisabeth Kapaki, Leonidas Stefanis, Marios Panas
BACKGROUND: The p. A53T mutation in the alpha-synuclein (SNCA) gene is a rare cause of autosomal dominant Parkinson's disease (PD). Although generally rare, it is particularly common in the Greek population due to a founder effect. A53T-positive PD patients often develop dementia during disease course and may very rarely present with dementia. METHODS: We screened for the p. A53T SNCA mutation a total of 347 cases of Greek origin with parkinsonism and/or dementia, collected over 15 years at the Neurogenetics Unit, Eginition Hospital, University of Athens...
December 9, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29194710/links-between-the-discovery-of-primates-and-anatomical-comparisons-with-humans-the-chain-of-being-our-place-in-nature-and-racism
#9
REVIEW
Rui Diogo
I focus on the crucial links between the discovery of nonhuman primates by Westerners, discussions on our place in nature, the chain of being, racism, and the history of primate comparative anatomy and of so-called "anatomical human racial studies." Strikingly, for more than a millennium humans knew more about the internal anatomy of a single monkey species than about that of their own bodies. This is because Galen used monkeys to infer human anatomy, in line with the human-animal continuity implied by the Greek notion of scala naturae...
December 1, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/29163731/acute-abdominal-pain-assessment-in-the-emergency-department-the-experience-of-a-greek-university-hospital
#10
Dimitrios Velissaris, Menelaos Karanikolas, Nikolaos Pantzaris, George Kipourgos, Vasileios Bampalis, Konstantina Karanikola, Eleftheria Fafliora, Christina Apostolopoulou, Charalampos Gogos
Background: Acute abdominal pain (AAP) is a common symptom in the emergency department (ED). Because abdominal pain can be caused by a wide spectrum of underlying pathology, evaluation of abdominal pain in the ED requires a comprehensive approach, based on patient history, physical examination, laboratory tests and imaging studies. The aim of this study was to investigate predictive factors for admission to the hospital in patients who presented to the ED with AAP as the main symptom...
December 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29150877/patients-with-spitz-nevi-in-the-greek-population-epidemiologic-clinical-and-histopathological-characteristics
#11
Efthymia Soura, Amerini Dimitrakopoulou, Erietta Christofidou, Alexander Katoulis, Christina Antoniou, Alexander Stratigos
BACKGROUND: Spitz nevi may present with clinical and histopathological atypical features that do not affect patient prognosis, but may become worrisome for patients ≥40 years presenting with newly appearing SN. OBJECTIVE: Patient characteristics and sun behavior patterns were investigated in correlation with age. SN characteristics and histopathological attributes were also investigated in correlation with age. METHODS: Patients with histopathologicaly confirmed diagnosis of SN were invited for a clinical examination...
November 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29150168/exploring-the-path-between-depression-anxiety-and-10-year-cardiovascular-disease-incidence-among-apparently-healthy-greek-middle-aged-adults-the-attica-study
#12
Natasa Kollia, Demosthenes Panagiotakos, Ekavi Georgousopoulou, Christina Chrysohoou, Mary Yannakoulia, Christodoulos Stefanadis, Somnath Chatterji, Josep Maria Haro, Charalabos Papageorgiou, Christos Pitsavos
OBJECTIVES: Although there is substantial evidence that psychological factors play an important role in the onset and course of cardiovascular disease (CVD), less is known about their combined effect and the pathways by which they affect cardiovascular health. The present work aimed to prospectively explore the effects of depression and anxiety on the 10-year CVD incidence, in relation to other lifestyle determinants, as linking factors in the context of the ATTICA study. Study design/Main outcome measures: The ATTICA study is a population-based, health and nutrition prospective cohort study (2002-2012), during which 853 middle-aged participants without a history of CVD [453 men (aged 45±13years) and 400 women (aged 44±18years)], underwent psychological evaluations at enrollment...
December 2017: Maturitas
https://www.readbyqxmd.com/read/29118499/causes-and-management-of-small-pupil-in-patients-with-cataract
#13
Ioannis Halkiadakis, Irini Chatziralli, Evangelos Drakos, Michail Katzakis, Sotirios Skouriotis, Eleni Patsea, Panagiotis Mitropoulos, Artemios Kandarakis
BACKGROUND: The purpose of the study was to present the causes and management of small pupil (<6 mm) in Greek patients with cataract. METHODS: About 1144 consecutive patients with cataract comprised the study group. The pupil size was measured after maximal dilation by means of Rosenbaum cards and Colvard pupillometer. Dilation regimen included phenylephrine 10%, tropicamide 1%, cyclopentolate 1%, and ketorolac trometamol 0.5% administered 3 times at 5 min intervals starting 1 h before surgery...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29099847/a-glimpse-at-the-intricate-mosaic-of-ethnicities-from-mesopotamia-paternal-lineages-of-the-northern-iraqi-arabs-kurds-syriacs-turkmens-and-yazidis
#14
Serkan Dogan, Cemal Gurkan, Mustafa Dogan, Hasan Emin Balkaya, Ramazan Tunc, Damla Kanliada Demirdov, Nihad Ahmed Ameen, Damir Marjanovic
Widely considered as one of the cradles of human civilization, Mesopotamia is largely situated in the Republic of Iraq, which is also the birthplace of the Sumerian, Akkadian, Assyrian and Babylonian civilizations. These lands were subsequently ruled by the Persians, Greeks, Romans, Arabs, Mongolians, Ottomans and finally British prior to the independence. As a direct consequence of this rich history, the contemporary Iraqi population comprises a true mosaic of different ethnicities, which includes Arabs, Kurds, Turkmens, Assyrians, and Yazidis among others...
2017: PloS One
https://www.readbyqxmd.com/read/29072186/greek-teachers-knowledge-about-attention-deficit-hyperactivity-disorder
#15
I Giannopoulou, P Korkoliakou, E Pasalari, A Douzenis
Attention deficit hyperactivity disorder (ADHD) is a neurobiological disorder, which affects about 5.2% of school-aged children worldwide. Children with ADHD present teachers with a special challenge, since they interfere with teaching process and do not respond to typical classroom management techniques. In order to meet this challenge teachers must have accurate, up-to-date, information about the disorder so that they can respond to the needs of the student with ADHD. Studies that have examined teachers' beliefs and knowledge relating to ADHD highlighted the need for providing training to increase Greek teachers' knowledge and understanding of the disorder...
July 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29054775/paul-of-aegina-625-690-his-work-and-his-contribution-to-neurological-surgery-trephinations-and-laminectomies-in-the-dark-ages
#16
REVIEW
Konstantinos Markatos, Demetrios Korres, Maria Kyriaki Kaseta, Marianna Karamanou, Georgios Androutsos
The purpose of this historical review is to summarize the work of Paul of Aegina and especially his contribution to the treatment of neurosurgical disorders and trauma. Paul performed trephinations for head injuries in the tradition of the Egyptian and the Greek schools of medicine. However he was an innovator in the treatment of several spine injuries as his choice to perform laminectomies and his description of them as safe and successful is unprecedented in the history of the recorded medicine and surgery...
October 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28975526/studies-of-life-history-of-gagea-graeca-liliaceae-based-on-morphological-and-molecular-methods
#17
Martin Schnittler, Akmaral Nursafina, Angela Peterson, Jens Peterson, Carl Barnick, Anja Klahr
BACKGROUND: We studied the life history of Gagea graeca (L.) A. Terracc. (sect. Anthericoides) by field surveys on the Greek island of Crete, including quantitative analyses of 405 individuals, estimation of resource allocation by measuring the nitrogen content of different plant organs, assessing seed set and recording genetic diversity via amplified fragment length polymorphism (AFLP) analyses. In contrast to most species of the genus G. graeca seems to be a short-lived perennial, developing several characters that are rather typical for annual plants...
October 3, 2017: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28974838/influence-of-arabian-pharmacy-on-diseases-tretament-during-ottoman-s-period-in-bosnia-and-herzegovina
#18
REVIEW
Armin Skrbo, Izet Masic
The Arab cultural heritage was an era of invaluable preservation and development of numerous teachings, including biomedical sciences. The golden period of Arab medicine deserves special attention in the history of medicine and pharmacy, as it was the period of rapid translation of works from Greek and Persian cultures into Arabic. They preserved their culture, and science from decay, and then adopted them to continue building their science on theirs as a basis. After the fall of Arabian Caliphate, Arabian pharmacy, continued to persevere, and spread through Turkish Caliphate until its fall in the First World War...
June 2017: Medical Archives
https://www.readbyqxmd.com/read/28937851/hpv-vaccine-acceptability-in-high-risk-greek-men
#19
Lea Hoefer, Savas Tsikis, George Bethimoutis, Electra Nicolaidou, Vassilios Paparizos, Christina Antoniou, Antonios Kanelleas, Leonidas Chardalias, Georgios-Emmanouil Stavropoulos, John Schneider, Angella Charnot-Katsikas
HPV is associated with malignancy in men, yet there is a lack of data on HPV knowledge, vaccine acceptability, and factors affecting vaccine acceptability in Greek men. This study aims to identify determinants of knowledge and willingness to vaccinate against HPV among high-risk Greek men. Men (n = 298) between the ages of 18 and 55 were enrolled from the STI and HIV clinics at "Andreas Syggros" Hospital in Athens, Greece from July-October 2015. Participants completed a survey on demographics, economic factors, sexual history, HPV knowledge, and vaccine acceptability...
September 22, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28933009/does-iris-in-bring-bad-news-or-good-news
#20
REVIEW
Silvio Buscemi, Davide Corleo, Carola Buscemi, Carla Giordano
Irisin, a novel myokine produced in response to physical activity, promotes white-to-brown fat transdifferentiation. The name irisin referred to the ancient Greek goddess Iris, the messenger who delivered (bad) news from the gods. In mice, it has been demonstrated that irisin plays a key role in metabolic regulation, energy expenditure and glucose homeostasis. New findings from various studies carried out in both animals and humans suggest that irisin might also have other favorable effects, such as increasing bone cortical mass, preventing hepatic lipid accumulation, and improving cognitive functions, thus mediating many exercise-induced health benefits...
September 20, 2017: Eating and Weight Disorders: EWD
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