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https://www.readbyqxmd.com/read/28929995/endocrinological-and-subjective-stress-responses-in-children-with-depressive-anxiety-or-externalizing-disorders
#1
Stephanie Stadelmann, Sonia Jaeger, Tina Matuschek, Yoon Ju Bae, Kai von Klitzing, Annette Maria Klein, Mirko Döhnert
In this study, we used a stress test to investigate endocrinological and subjective stress responses of 8- to 14-year-old children with internalizing or externalizing disorders and healthy controls. The sample (N = 170) consisted of clinical and community children. Parents were given a diagnostic interview to diagnose their children's psychiatric condition. We measured saliva cortisol and subjectively experienced arousal in children before and after the Trier Social Stress Test for Children. Children also rated their performance immediately after the stress test, and 1 hr later they rated their positive and negative thoughts about this stressful event...
September 20, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28929582/the-effectiveness-of-a-psychoeducation-intervention-delivered-via-whatsapp-for-mothers-of-children-with-autism-spectrum-disorder-asd-in-the-kingdom-of-saudi-arabia-a-randomized-controlled-trial
#2
A Hemdi, D Daley
BACKGROUND: Mothers of children with autism spectrum disorder (ASD) report high levels of stress and lower levels of well-being than parents of typically developing children. Current interventions for ASD typically focus on working with the child rather than delivering strategies to help support parents. OBJECTIVE: To evaluate the effectiveness of a psychoeducation intervention developed to support mothers of children with ASD in Saudi Arabia. METHOD: Sixty-two mothers (23-52 years) of children (26-78 months) were recruited to a multisite randomized controlled trials of the intervention...
September 20, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28929082/endocrine-therapy-of-estrogen-receptor-positive-breast-cancer-cells-early-differential-effects-on-stem-cell-markers
#3
Euphemia Y Leung, Marjan E Askarian-Amiri, Debina Sarkar, Carole Ferraro-Peyret, Wayne R Joseph, Graeme J Finlay, Bruce C Baguley
INTRODUCTION: Endocrine therapy of breast cancer, which either deprives cancer tissue of estrogen or prevents estrogen pathway signaling, is the most common treatment after surgery and radiotherapy. We have previously shown for the estrogen-responsive MCF-7 cell line that exposure to tamoxifen, or deprivation of estrogen, leads initially to inhibition of cell proliferation, followed after several months by the emergence of resistant sub-lines that are phenotypically different from the parental line...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28927904/lipophilic-methylene-violet-analogues-as-modulators-of-mitochondrial-function-and-dysfunction
#4
Sandipan Roy Chowdhury, Omar M Khdour, Indrajit Bandyopadhyay, Sidney M Hecht
In an effort to identify methylene blue analogues having improved antioxidant activity, a series of new methylene violet analogues have been designed and synthesized. The analogues were prepared following a synthetic route that is more efficient than the previously reported methods, both in terms of yield and purity of the final products. The route involves the Smiles rearrangement as one of the crucial steps. Smiles rearrangement of suitably substituted diphenyl sulfide intermediates afforded the corresponding phenothiazine analogues in high yields, which were subsequently converted to the final products...
August 18, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28927771/-impact-of-a-written-document-for-preoperative-information-on-the-use-of-internet-by-parents
#5
M Landier, T Villemagne, A Le Touze, K Braïk, P Meignan, A R Cook, B Morel, H Lardy, A Binet
INTRODUCTION: Preoperative information is a legal and ethical obligation. Very few studies have evaluated the preoperative information method in pediatrics. Having a child operated on is stressful for parents. The use of Internet to look for data on the pathology and its treatment is frequent, but often unprofitable and sometimes even harmful. This study aimed to measure the impact of a leaflet, which supports spoken information in preoperative consultation, on parents' use of the Internet before surgery...
September 15, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28926597/altered-embryonic-development-in-northern-bobwhite-quail-colinus-virginianus-induced-by-pre-incubation-oscillatory-thermal-stresses-mimicking-global-warming-predictions
#6
Kelly S Reyna, Warren W Burggren
Global warming is likely to alter reproductive success of ground-nesting birds that lay eggs normally left unattended for days or even weeks before actual parental incubation, especially in already warm climates. The native North American bobwhite quail (Colinus virginianus) is such a species, and pre-incubation quail eggs may experience temperatures ≥45°C. Yet, almost nothing is known about embryonic survival after such high pre-incubation temperatures. Freshly laid bobwhite quail eggs were exposed during a 12 day pre-incubation period to one of five thermal regimes: low oscillating temperatures (25-40°C, mean = 28...
2017: PloS One
https://www.readbyqxmd.com/read/28925341/physiological-attunement-in-mother-infant-dyads-at-clinical-high-risk-the-influence-of-maternal-depression-and-positive-parenting
#7
Cassandra L Hendrix, Zachary N Stowe, D Jeffrey Newport, Patricia A Brennan
A growing number of research studies have examined the intradyadic coregulation (or attunement) of hypothalamus-pituitary-adrenal axis functioning in mothers and their children. However, it is unclear how early this coregulation may be present in dyads at clinical high risk and whether certain factors, such as maternal depression or positive parenting, are associated with the strength of this coregulation. The present study examined cortisol attunement within mother-infant dyads in a high-risk sample of 233 mothers who received treatment for psychiatric illness during pregnancy and whose infants were 6 months old at the study visit...
September 19, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28924262/prenatal-glucocorticoid-exposure-modifies-endocrine-function-and-behaviour-for-3-generations-following-maternal-and-paternal-transmission
#8
Vasilis G Moisiadis, Andrea Constantinof, Alisa Kostaki, Moshe Szyf, Stephen G Matthews
Fetal exposure to high levels of glucocorticoids programs long-term changes in the physiologic stress response and behaviours. However, it is not known whether effects manifest in subsequent generations of offspring following maternal (MT) or paternal (PT) transmission. We treated pregnant guinea pigs with three courses of saline or synthetic glucocorticoid (sGC) at a clinically relevant dose. Altered cortisol response to stress and behaviours transmitted to juvenile female and male F2 and F3 offspring from both parental lines...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28922259/gastrointestinal-symptoms-of-food-challenge-proven-non-ige-cow-s-milk-allergy-are-dissipated-by-early-school-age
#9
Noora Helin, Kaija-Leena Kolho, Erik Qvist, Mika Mäkelä, Laura Merras-Salmio
OBJECTIVES: To evaluate the current well-being and dietary restrictions in children six years after food challenge confirmed diagnosis of non-IgE cow's milk protein allergy, compared to peers with gastrointestinal symptoms but negative food challenge. To evaluate the diagnostic process retrospectively. METHODS: Internet-based survey for mothers whose children underwent six years ago the double-blind, placebo-controlled food challenge for cow's milk because of gastrointestinal symptoms causing suspicion of non-IgE cow's milk protein allergy...
September 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28921773/performance-of-aneuploid-backcross-hybrids-between-the-crop-brassica-napus-and-its-wild-relative-b-rapa
#10
Tom J de Jong, Karla Escobedo Quevedo, Karin C A M van der Veen-van Wijk, Mahmoud Moshgani
Crossings between the diploid wild Brassica rapa (AA, 2n=20) and the tetraploid cultivar B. napus (AACC, 2n=38) can readily be made. Backcrosses to the wild B. rapa (BC1 ) produce aneuploids with variable chromosome numbers between 20 and 29. How does survival and performance relate to DNA content of plants? Growth of the BC1 plants was measured in the lab. One plant in the F1 self-pollinated spontaneously and produced abundant F2 seeds that were also examined. The number of C-chromosomes was estimated from DNA-values obtained with flow cytometry...
September 16, 2017: Plant Biology
https://www.readbyqxmd.com/read/28916433/resilience-in-families-of-children-with-autism-and-sleep-problems-using-mixed-methods
#11
Cristine A Roberts, Jennifer Hunter, An-Lin Cheng
PURPOSE: About 80% of children with autism spectrum disorder (ASD) have sleep problems that may disrupt optimal family functioning. We explored the impact of sleep problems on families' resilience. DESIGN AND METHODS: An explanatory sequential mixed methods design was used to discern whether resilience differed between families whose children with ASD have or do not have sleep problems, to seek predictors for family hardiness/resilience, and to determine whether narrative findings support, expand, or conflict quantitative findings...
September 12, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28915072/parent-driven-campaign-videos-an-analysis-of-the-motivation-and-affect-of-videos-created-by-parents-of-children-with-complex-healthcare-needs
#12
Bernie Carter, Lucy Bray, Paula Keating, Catherine Wilkinson
Caring for a child with complex health care needs places additional stress and time demands on parents. Parents often turn to their peers to share their experiences, gain support, and lobby for change; increasingly this is done through social media. The WellChild #notanurse_but is a parent-driven campaign that states its aim is to "shine a light" on the care parents, who are not nurses, have to undertake for their child with complex health care needs and to raise decision-makers' awareness of the gaps in service provision and support...
September 15, 2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/28913952/new-age-ideas-about-age-old-sex-separating-meiosis-from-mating-could-solve-a-century-old-conundrum
#13
Michael Brandeis
Ever since Darwin first addressed it, sexual reproduction reigns as the 'queen' of evolutionary questions. Multiple theories tried to explain how this apparently costly and cumbersome method has become the universal mode of eukaryote reproduction. Most theories stress the adaptive advantages of sex by generating variation, they fail however to explain the ubiquitous persistence of sexual reproduction also where adaptation is not an issue. I argue that the obstacle for comprehending the role of sex stems from the conceptual entanglement of two distinct processes - gamete production by meiosis and gamete fusion by mating (mixis)...
September 14, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28913886/what-s-parenting-got-to-do-with-it-emotional-autonomy-and-brain-and-behavioral-responses-to-emotional-conflict-in-children-and-adolescents
#14
Hilary A Marusak, Moriah E Thomason, Kelsey Sala-Hamrick, Laura Crespo, Christine A Rabinak
Healthy parenting may be protective against the development of emotional psychopathology, particularly for children reared in stressful environments. Little is known, however, about the brain and behavioral mechanisms underlying this association, particularly during childhood and adolescence, when emotional disorders frequently emerge. Here, we demonstrate that psychological control, a parenting strategy known to limit socioemotional development in children, is associated with altered brain and behavioral responses to emotional conflict in 27 at-risk (urban, lower income) youth, ages 9-16...
September 15, 2017: Developmental Science
https://www.readbyqxmd.com/read/28912785/genotyping-by-sequencing-gbs-revealed-molecular-genetic-diversity-of-iranian-wheat-landraces-and-cultivars
#15
Hadi Alipour, Mohammad R Bihamta, Valiollah Mohammadi, Seyed A Peyghambari, Guihua Bai, Guorong Zhang
Background: Genetic diversity is an essential resource for breeders to improve new cultivars with desirable characteristics. Recently, genotyping-by-sequencing (GBS), a next-generation sequencing (NGS) technology that can simplify complex genomes, has now be used as a high-throughput and cost-effective molecular tool for routine breeding and screening in many crop species, including the species with a large genome. Results: We genotyped a diversity panel of 369 Iranian hexaploid wheat accessions including 270 landraces collected between 1931 and 1968 in different climate zones and 99 cultivars released between 1942 to 2014 using 16,506 GBS-based single nucleotide polymorphism (GBS-SNP) markers...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28912344/parasex-generates-phenotypic-diversity-de-novo-and-impacts-drug-resistance-and-virulence-in-candida-albicans
#16
Matthew P Hirakawa, Darius E Chyou, Denis Huang, Aaron R Slan, Richard J Bennett
Candida albicans is a diploid fungus that is a frequent cause of mucosal and systemic infections in humans. This species exhibits an unusual parasexual cycle in which mating produces tetraploid cells that undergo a non-meiotic program of concerted chromosome loss to return to a diploid or aneuploid state. In this work, we used a multipronged approach to examine the capacity of parasex to generate diversity in C. albicans First, we compared the phenotypic properties of 32 genotyped progeny and observed wide-ranging differences in fitness, filamentation, biofilm formation and virulence...
September 14, 2017: Genetics
https://www.readbyqxmd.com/read/28911938/-families-experiences-and-satisfaction-with-a-pediatric-emergency-service
#17
S Perret, M Gehri, J Pluies, I Rossi, C Akre
OBJECTIVE: Today, pediatric emergency services receive a rising number of "non-urgent" cases, which are due to parental anxiety or a miscomprehension of medical explanations. The aim of this study was therefore to understand what those families experience and need when they consult in such cases, in order to respond with adapted solutions. METHODS: Semi-structured interviews and questionnaires with parents, after the consultation or in the waiting room. RESULTS: Based on the families' narratives, we present the results in six steps, which correspond to the steps they experience from the decision to go to the hospital to the consultation...
September 11, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28911874/childhood-adversity-predicts-reduced-physiological-flexibility-during-the-processing-of-negative-affect-among-adolescents-with-major-depression-histories
#18
Shimrit Daches, Maria Kovacs, Charles George, Ilya Yaroslavsky, Eniko Kiss, Agnes Vetro, Roberta Dochnal, István Benak, Ildikó Baji, Kitti Halas, Attila Makai, Krisztina Kapornai, Jonathan Rottenberg
BACKGROUND: Adversity during early development has been shown to have enduring negative physiological consequences. In turn, atypical physiological functioning has been associated with maladaptive processing of negative affect, including its regulation. The present study therefore explored whether exposure to adverse life events in childhood predicted maladaptive (less flexible) parasympathetic nervous system functioning during the processing of negative affect among adolescents with depression histories...
September 11, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28910130/and-still-we-rise-parent-child-relationships-resilience-and-school-readiness-in-low-income-urban-black-families
#19
Riana Elyse Anderson
The Family Stress Model acknowledges forms of resilience in the face of hardship; however, few studies have emerged on the potentially positive role of familial relationships in the academic, psychological, and prosocial success of impoverished Black children. The current study evaluates how parent-child relationship conflict and financial stress are associated with children's school readiness (i.e., academic, psychosocial, and socioemotional indicators). Latent profile analyses, incorporating financial stress, general stress, and parent-child relationship variables were used to test whether varying family stress profiles differentially predicted children's school readiness in Black families with children entering kindergarten (N = 292)...
September 14, 2017: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/28904958/transcriptomic-analysis-reveals-genes-mediating-salt-tolerance-through-calcineurin-ccha-independent-signaling-in-aspergillus-nidulans
#20
Sha Wang, Hongchang Zhou, Jun Wu, Jiangyu Han, Shasha Li, Shengwen Shao
Adaptation to changes in the environment is crucial for the viability of all organisms. Although the importance of calcineurin in the stress response has been highlighted in filamentous fungi, little is known about the involvement of ion-responsive genes and pathways in conferring salt tolerance without calcium signaling. In this study, high-throughput RNA-seq was used to investigate salt stress-induced genes in the parent, ΔcnaB, and ΔcnaBΔcchA strains of Aspergillus nidulans, which differ greatly in salt adaption...
2017: BioMed Research International
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