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https://www.readbyqxmd.com/read/28728107/developing-potential-agents-against-atherosclerosis-design-synthesis-and-pharmacological-evaluation-of-novel-dual-inhibitors-of-oxidative-stress-and-squalene-synthase-activity
#1
Maria G Katselou, Alexios N Matralis, Angeliki P Kourounakis
For the treatment of multifactorial and complex diseases, it has become increasingly apparent that compounds acting at multiple targets often deliver superior efficacy compared to compounds with high specificity for only a single target. Based on previous studies demonstrating the important antioxidant and anti-hyperlipidemic effect of morpholine and 1,4-benzo(x/thi)azine derivatives (A-E), we hereby present the design, synthesis and pharmacological evaluation of novel dual-acting molecules as a therapeutic approach for atherosclerosis...
June 24, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28727098/transport-stress-induced-cerebrum-oxidative-stress-is-not-mitigated-by-activating-the-nrf2-antioxidant-defense-response-in-newly-hatched-chicks
#2
J Ge, H Li, F Sun, X-N Li, J Lin, J Xia, C Zhang, J-L Li
Transportation of newly hatched chicks from the hatchery to the farm is inevitable, especially for parent stock and grandsire parent stock chicks. However, the possible effects of transport stress in the newly hatched chicks are poorly understood. The aim of this study was to determine the adaptive responses to transport stress by activing the nuclear factor-erythroid 2-related factor 2 (Nrf2)-induced antioxidant defense. One hundred twenty newly hatched chicks were divided into 3 groups (control group, transport group, and simulation transport group) for 2, 4, and 8 h of real or simulated transportation...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726338/household-fear-of-deportation-in-mexican-origin-families-relation-to-body-mass-index-percentiles-and-salivary-uric-acid
#3
Airín D Martínez, Lillian Ruelas, Douglas A Granger
OBJECTIVE: Fear of deportation (FOD) is a prevalent concern among mixed-status families. Yet, our understanding of how FOD shapes human health and development is in its infancy. To begin to address this knowledge gap, we examined the relationship between household FOD, body mass index (BMI) percentiles and salivary uric acid (sUA), a biomarker related to oxidative stress/hypertension/metabolic syndrome, among 111 individuals living in Mexican-origin families. METHODS: Participants were 65 children (2 months-17 years, 49% female) and 46 adults (20-58 years, 71% female) living in 30 Mexican-origin families with at least one immigrant parent in Phoenix, AZ...
July 20, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28725257/study-protocol-an-investigation-of-mother-infant-signalling-during-breastfeeding-using-a-randomised-trial-to-test-the-effectiveness-of-breastfeeding-relaxation-therapy-on-maternal-psychological-state-breast-milk-production-and-infant-behaviour-and-growth
#4
N H M Shukri, J Wells, F Mukhtar, M H S Lee, M Fewtrell
BACKGROUND: The physiological and psychological signalling between mother and infant during lactation is one of the prominent mother-infant factors that may influence breastfeeding outcomes. The infant can 'signal' his needs through vocalisation, and the mother can respond by allowing or restricting nipple access, which might alter the breast milk composition or volume. This may lead to parent-offspring conflict during the lactation period. Challenging infant behaviour has also been associated with maternal psychological distress, which might affect breastfeeding performance...
2017: International Breastfeeding Journal
https://www.readbyqxmd.com/read/28725101/social-policies-and-families-in-stress-gender-and-educational-differences-in-work-family-conflict-from-a-european-perspective
#5
Natascha Notten, Daniela Grunow, Ellen Verbakel
In modern welfare states, family policies may resolve the tension between employment and care-focused demands. However these policies sometimes have adverse consequences for distinct social groups. This study examined gender and educational differences in working parents' perceived work-family conflict and used a comparative approach to test whether family policies, in particular support for child care and leave from paid work, are capable of reducing work-family conflict as well as the gender and educational gaps in work-family conflict...
2017: Social Indicators Research
https://www.readbyqxmd.com/read/28721912/exosomes-and-exosomal-micrornas-in-prostate-cancer-radiation-therapy
#6
REVIEW
Bijaya Malla, Kathrin Zaugg, Erik Vassella, Daniel M Aebersold, Alan Dal Pra
Despite current risk stratification systems using traditional clinicopathologic factors, many localized and locally advanced prostate cancers fail radical treatment (ie, radical prostatectomy, radiation therapy with or without androgen deprivation therapy). Therefore, a pressing need exists for enhanced methods of disease stratification through novel prognostic and predictive tools that can reliably be applied in clinical practice. Exosomes are 50- to 150-nm small vesicles released by cancer cells that reflect the genetic and nongenetic materials of parent cancer cells...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28721576/experiences-of-formal-and-informal-caregivers-of-older-persons-in-singapore
#7
Kalyani K Mehta, Thang Leng Leng
The well-being of informal caregivers in the familial context is increasingly recognized as a critical area of concern affecting the care of older family members. This paper focuses on the dynamics of family caregiving for older members from the work-life perspective, contextualised in the highly developed and rapidly ageing society that is Singapore. Drawing from qualitative research on 30 adult family caregivers and 15 live-in foreign domestic workers (FDWs), the main themes identified from the qualitative interviews were: 1) Stresses and dilemmas faced by family caregivers; 2) Filial responsibility in the caring for one's parents; 3) Coping with work and caregiving - FDWs in family caregiving; 4) Coping with extra help - hiring of FDWs and challenges...
July 18, 2017: Journal of Cross-cultural Gerontology
https://www.readbyqxmd.com/read/28720734/lack-of-acrb-efflux-function-confers-loss-of-virulence-on-salmonella-enterica-serovar-typhimurium
#8
Xuan Wang-Kan, Jessica M A Blair, Barbara Chirullo, Jonathan Betts, Roberto M La Ragione, Alasdair Ivens, Vito Ricci, Timothy J Opperman, Laura J V Piddock
AcrAB-TolC is the paradigm resistance-nodulation-division (RND) multidrug resistance efflux system in Gram-negative bacteria, with AcrB being the pump protein in this complex. We constructed a nonfunctional AcrB mutant by replacing D408, a highly conserved residue essential for proton translocation. Western blotting confirmed that the AcrB D408A mutant had the same native level of expression of AcrB as the parental strain. The mutant had no growth deficiencies in rich or minimal medium. However, compared with wild-type SL1344, the mutant had increased accumulation of Hoechst 33342 dye and decreased efflux of ethidium bromide and was multidrug hypersusceptible...
July 18, 2017: MBio
https://www.readbyqxmd.com/read/28720385/differences-of-lipid-membrane-modulation-and-oxidative-stress-by-digoxin-and-21-benzylidene-digoxin
#9
Lilian Nd Silva, Silmara Lg Alves, Jessica Venugopal, Vanessa F Cortes, Herica L Santos, José Afp Villar, Leandro A Barbosa
Cardiotonic steroids (CTS) are compounds which bind to the Na,K-ATPase, leading to its inhibition and in some cases initiating signaling cascades. Long utilized as a treatment for congestive heart disease, CTS have more recently been observed to inhibit proliferation and cause apoptosis in several cancer cell lines. A synthetic derivative of the CTS digoxin, called 21-benzylidene digoxin (21-BD), activates the Na,K-ATPase rather than cause its inhibition, as its parent compound does. Here, the mechanism behind the unique effects of 21-BD are further explored...
July 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28717654/fusion-to-flaviviral-leader-peptide-targets-hiv-1-reverse-transcriptase-for-secretion-and-reduces-its-enzymatic-activity-and-ability-to-induce-oxidative-stress-but-has-no-major-effects-on-its-immunogenic-performance-in-dna-immunized-mice
#10
Anastasia Latanova, Stefan Petkov, Yulia Kuzmenko, Athina Kilpeläinen, Alexander Ivanov, Olga Smirnova, Olga Krotova, Sergey Korolev, Jorma Hinkula, Vadim Karpov, Maria Isaguliants, Elizaveta Starodubova
Reverse transcriptase (RT) is a key enzyme in viral replication and susceptibility to ART and a crucial target of immunotherapy against drug-resistant HIV-1. RT induces oxidative stress which undermines the attempts to make it immunogenic. We hypothesized that artificial secretion may reduce the stress and make RT more immunogenic. Inactivated multidrug-resistant RT (RT1.14opt-in) was N-terminally fused to the signal providing secretion of NS1 protein of TBEV (Ld) generating optimized inactivated Ld-carrying enzyme RT1...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28717515/changing-needs-for-information-and-support-in-an-online-system-for-parents-of-children-with-kidney-disease
#11
Maury Pinsk, David Nicholas
BACKGROUND: Pediatric chronic kidney disease is psychologically, financially, and physically demanding on parents providing care. Parents often feel isolated because of the rarity of the condition, and geographic isolation often compounds this perception in Canada. Many parents seek assistance online for both information and social support. OBJECTIVE: This study examines an online portal, titled "Ability Online," which was designed to provide support and information to a diverse group of parents using chat facilities, bulletin boards, and e-mail...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28717216/random-mutagenesis-analysis-and-identification-of-a-novel-c2h2-type-transcription-factor-from-the-nematode-trapping-fungus-arthrobotrys-oligospora
#12
Dewei Jiang, Jing Zhou, Guizhen Bai, Xinjing Xing, Liyan Tang, Xuewei Yang, Juan Li, Ke-Qin Zhang, Jinkui Yang
Arthrobotrys oligospora is a typical nematode-trapping fungus. In this study, 37 transformants of A. oligospora were obtained by REMI (restriction enzyme mediated integration) method and phenotypic properties of nine transformants were analyzed. The nine transformants showed differences in growth, conidiation, trap formation, stress tolerance, and/or pathogenicity among each other and with those of the parental wild-type strain (WT). The insertional sites of the hph cassette were identified in transformants X5 and X13...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28713805/the-benefits-and-challenges-of-managing-asthma-in-hispanic-families-in-south-texas-a-mixed-methods-study
#13
Genny Carrillo, Maria J Perez-Patron, Rose L Lucio, Lucia Cabrera, Alyssa Trevino, Xiaohui Xu, Nelda Mier
BACKGROUND: Understanding the experience of Hispanic parents of children diagnosed with asthma can be useful in the delivery of effective and meaningful asthma education. In order to assess the needs of Hispanic families with asthmatic children in South Texas, investigators utilized a combination of qualitative and quantitative research methods. OBJECTIVES: This study aimed (1) to assess the impact of asthma in the quality of life of Hispanic children and their families and (2) to identify barriers and challenges to asthma management as perceived by parents of children diagnosed with asthma...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28713797/health-related-quality-of-life-after-pediatric-liver-transplantation-a-qualitative-analysis-of-the-perspectives-of-health-care-providers
#14
Mar Miserachs, David B Nicholas, Anthony R Otley, Vicky Lee Ng
With improved survival outcomes after pediatric liver transplantation (LT), health-related quality of life (HRQoL) is an important outcome metric. Understanding the elements contributing to HRQoL after LT in children would enable more targeted strategies towards optimizing best outcomes. This qualitative study aimed to explore health care providers (HCP) perceptions about HRQoL after pediatric LT. Thirteen experienced HCP participated in two focus group discussions. Data analysis via a thematic analysis approach revealed 4 major themes: "LT as a facilitator of better HRQoL," "coping and adapting to LT," "living with a transplanted liver," and "the family context...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28713306/parenting-with-ptsd-a-review-of-research-on-the-influence-of-ptsd-on-parent-child-functioning-in-military-and-veteran-families
#15
REVIEW
Suzannah K Creech, Gabriela Misca
Posttraumatic stress disorder (PTSD) is strongly associated with exposure to war related trauma in military and veteran populations. In growing recognition that PTSD may influence and be influenced by social support and family systems, research has begun to explore the effects that war related trauma and the ensuing PTSD may have on varied aspects of close relationship and family functioning. Far less research, however, has examined the influence of war-related PTSD on parent-child functioning in this population...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28712816/enhanced-startle-reflexivity-during-presentation-of-visual-nurture-cues-in-young-adults-who-experienced-parental-divorce-in-early-childhood
#16
Xenia Hengesch, Mauro F Larra, Johannes B Finke, Terry D Blumenthal, Hartmut Schächinger
Adverse childhood experiences (ACE) may influence stress and affective processing in adulthood. Animal and human studies show enhanced startle reflexivity in adult participants with ACE. This study examined the impact of one of the most common ACE, parental divorce, on startle reflexivity in adulthood. Affective modulation of acoustically-elicited startle eye blink was assessed in a group of 23 young adults with self-reported history of parental divorce, compared to an age- and sex-matched control group (n=18)...
July 13, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28712114/comparative-evaluation-of-human-heat-stress-indices-on-selected-hospital-admissions-in-sydney-australia
#17
James Goldie, Lisa Alexander, Sophie C Lewis, Steven Sherwood
OBJECTIVE: To find appropriate regression model specifications for counts of the daily hospital admissions of a Sydney cohort and determine which human heat stress indices best improve the models' fit. METHODS: We built parent models of eight daily counts of admission records using weather station observations, census population estimates and public holiday data. We added heat stress indices; models with lower Akaike Information Criterion scores were judged a better fit...
July 16, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28711770/multigenerational-effects-evaluation-of-the-flame-retardant-tris-2-butoxyethyl-phosphate-tboep-using-daphnia-magna
#18
Maeva Giraudo, Maxime Dubé, Mélanie Lépine, Pierre Gagnon, Mélanie Douville, Magali Houde
Tris(2-butoxyethyl) phosphate (TBOEP) is an organophosphate ester used as substitute following the phase-out of brominated flamed retardants. Because of its high production volume and its use in a broad range of applications, this chemical is now frequently detected in the environment and biota. However, limited information is available on the long-term effects of TBOEP in aquatic organisms. In this study, Daphnia magna were exposed over three 21d generations to an environmentally relevant concentration of TBOEP (10μg/L) and effects were evaluated at the gene transcription, protein, and life-history (i...
July 8, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28711513/the-effectiveness-of-cognitive-function-stress-management-training-in-glycemic-control-in-children-and-in-mental-health-of-mother-caring-for-child-with-type-1-diabetes-mellitus
#19
Mozhdeh Saghaei, Pouya Omidi, Elham Hashemi Dehkordi, Parvin Safavi
AIM: The study was aimed to evaluate the effectiveness of a training course of cognitive-behavioral stress management in glycaemia regulation in children with type 1 diabetes mellitus as well as in mental health status of their mothers. MATERIALS AND METHODS: Fifty children with type 1 diabetes mellitus and their mothers were selected and randomly assigned into two groups. A group of mothers (n=25; as experimental one besides their children) passed a course, eight 2-h sessions, on the cognitive-behavioral and stress management, and the control group received the usual care...
July 3, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28710975/paternal-history-of-mental-illness-associated-with-posttraumatic-stress-disorder-among-veterans
#20
Megan Shepherd-Banigan, Michelle L Kelley, Jodie G Katon, John F Curry, Karen M Goldstein, Mira Brancu, H Ryan Wagner, Teresa E Fecteau, Courtney H Van Houtven
This study examined the association between parent and family reported history of non-PTSD mental illness (MI), PTSD specifically, and substance use problems, and participant clinical diagnosis of PTSD. Participants were drawn from the US Department of Veterans Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center (MIRECC) Post-Deployment Mental Health (PDMH) study (n = 3191), an ongoing multi-site cohort study of US Afghanistan and Iraq conflict era veterans. Participants who recalled a father history of PTSD had a 26-percentage point higher likelihood of meeting criteria for PTSD; while participants reporting any family history of PTSD had a 15-percentage point higher probability of endorsing symptoms consistent with PTSD...
June 17, 2017: Psychiatry Research
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