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Albert Roger, Maria Basagana, Aina Teniente-Serra, Nathalie Depreux, Yanina Jurgens, Clara Padro, Sira Miquel, Carolina Elduque, Eva M Martinez-Caceres
Nowadays, specific immunotherapy is the only successful disease-modifying therapy for IgE-mediated allergic diseases. In this review we analyse different antigen-specific immunotherapies according to administration route, type of antigens and adjuvants, and we address the special case of food allergy.
January 15, 2018: Current Pharmaceutical Design
Cláudia M Rodrigues, Bruna F Matias, Eddie F C Murta, Márcia A Michelin
INTRODUCTION: Cancer stems from mutations in specific genes that induce uncontrolled cell proliferation. Dendritic cells (DCs) are important immunologic cells and play a crucial role in the induction of an antitumour response. PATIENTS AND METHODS: We examined the immune response mediated by T lymphocytes, helper T cells, cytotoxic T cells, and regulatory T cells, as well as the cytokines [interleukin (IL)-2, IL-12, interferon (IFN)-γ, tumour necrosis factor (TNF)-α and IL-10], produced by these cell populations, in cancer patients (N = 7) undergoing immunotheraphy with autologous DCs...
2011: Clinical Medicine Insights. Oncology
Tunc Akkoc, Mübeccel Akdis, Cezmi A Akdis
Allergic diseases represent a complex innate and adoptive immune response to natural environmental allergens with Th2-type T cells and allergen-specific IgE predominance. Allergen-specific immunotherapy is the most effective therapeutic approach for disregulated immune response towards allergens by enhancing immune tolerance mechanisms. The main aim of immunotherapy is the generation of allergen nonresponsive or tolerant T cells in sensitized patients and downregulation of predominant T cell- and IgE-mediated immune responses...
January 2011: Allergy, Asthma & Immunology Research
Hwa-Jeong Lee, Jun Lee, Sun-Kyung Lee, Suk-Keun Lee, Eun-Cheol Kim
BACKGROUND: Interleukin-8 (IL-8) is a cytokine that plays an important role in tumor progression in a variety of cancer types; however, its regulation is not well understood in oral cancer cells. In the present study, we examined the expression and mechanism of IL-8 in which it is involved by treating immortalized (IHOK) and malignant human oral keratinocytes (HN12) cells with deferoxamine (DFO). METHODS: IL-8 production was measured by an enzyme-linked immunoabsorbent assay and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis...
2007: BMC Cancer
R Toni, P Mirandola, G Gobbi, M Vitale
The morphogenetic events leading to the transendothelial passage of lymphoid and tumoral cells are analyzed in light of a very recent and global theory of intercellular communication designated as the Triune Information Network (TIN). The TIN system is based on the assumption that cell-cell interactions primarily occur through cell surface informations or topobiological procesess, whose mechanisms rely upon expression of adhesion molecules, and are regulated by an array of locally-borne (autocrine/paracrine signals and autonomic inputs) and distantly-borne (endocrine secretions) messages...
2007: European Journal of Histochemistry: EJH
A Roll, G Hofbauer, B K Ballmer-Weber, P Schmid-Grendelmeier
BACKGROUND: Ultra-rush induction of immunotherapy with Hymenoptera venom is a reliable and efficacious alternative to the rush induction protocol, though not widely used in European countries yet. Its safety, however, has been intensively discussed over the last few years. The aim of this retrospective case study was to examine the rate of allergic side-effects during our four-hour ultra-rush hymenoptera venom induction regimen. We evaluated risk factors for observed side-effects such as age, gender, severity of previous insect sting reactions according to the H...
2006: Journal of Investigational Allergology & Clinical Immunology
A Arena, E Barbatano, E Gammeri, M Bruno, G Riva
In order evaluate the long-term benefit of Specific ImmunoTherapy (SIT), administered either subcutaneously or sublingually, in comparison with drug therapy, in terms of efficacy, tolerability and patients' adherence to the treatment, a three year perspective, observational study was carried out over tree years in a rather large number of allergic subjects. One hundred and ten patients of both sex (50F, 60M; age: 22.4 - 35.5 years) were admitted. Sixty of them were rhinitics, some with concomitant mild intermittent asthma or conjunctivitis; 43 had a persistent asthma, often with concomitant rhinitis...
September 2003: International Journal of Immunopathology and Pharmacology
Maria Huber, Wiltrud Baier, Wolfgang G Bessler, Lutz Heinevetter
We compared the adjuvanticity of the synthetic lipopeptide P3CSK4 of bacterial origin and the plant-derived adjuvant saponin using the wheat storage protein gliadin as antigen. Gluten sensitive BALB/c mice were orally immunized with gliadin in a mixture with either lipopeptide or saponin. The gliadin-specific serum IgG response was markedly enhanced by the saponin adjuvant. The lipopeptide adjuvant enhanced the IgG2a response, but reduced IgG1 production. In contrast, the saponin adjuvant enhanced both IgG2a and IgG1, and the sera showed elevated specific IgE concentrations...
March 2002: Immunobiology
T Guida, V Belsito Petrizzi, R Fiorentino, D Germano, R Guardasi, M L Lentini-Graziano, G Cartenì
The clinical and biological characteristics of neuroectodermal tumours (NETs) are such that their treatment is necessarily multidisciplinary. Surgery is the first therapeutic choice given that it is the only potentially curative treatment for this type of neoplasm. Medical treatment is mainly indicated in the treatment of metastatic disease and must be separated into three basic options: chemotherapy, immunotheraphy and hormone treatment. Owing to the low proliferative index generally found in NETs, chemotherapy is not very effective as a means of controlling tumour growth...
December 2001: Minerva Endocrinologica
D Altintaş, N Akmanlar, S Güneşer, R Burgut, M Yilmaz, R Buğdayci, P Aksungur
BACKGROUND: dermatophagoides pteronyssinus (Der PI) is the major allergen which causes allergic asthma and perennial rhinitis. The extracts of Der PI may be used in treatment of patients who are unresponsive to pharmacological treatment and avoidance of allergens. The success of immunotherapy (IT) depends on the selection of appropriate patients and allergens as well as a regular follow up. OBJECTIVE: three different groups of IT materials and a placebo were tested on 34 patients with Der PI sensitive asthma...
November 1999: Allergologia et Immunopathologia
P C Stokkers, L Camoglio, S J van Deventer
The inflammatory bowel diseases frequently require surgery because of intestinal complications. Animal models of inflammatory bowel disease, in particular those that histopathologically resemble Crohn's disease, are characterized by increased mucosal TNF production, and anti-TNF antibodies have shown efficacy in decreasing disease activity. These data have provided a rationale for immunotheraphy of Crohn's disease. Administration of anti-TNF antibodies to patients with Crohn's disease not responding to standard immunosuppressive treatment rapidly induced complete remissions, and healing of intestinal ulceration...
1995: Journal of Inflammation
A Trofimowicz, E Rzepecka, J Hofman
The clinical results of specific immunotheraphy using Pollinex, Catalet, or Alavac S-HDM vaccines in 22 patients with atopic dermatitis are presented. The immunotheraphy in children with allergy to Dermatophagoides lasted for about 3 years and in children allergic to pollen grass antigens 3 pollen seasons. In the group of children submitted to specific immunotheraphy with Dermatophagoides antigens very good and good results after 3 years of treatment were observed in 75% of patients. In the patients treated with grass pollen antigens Catalet or Pollinex very good and good results were noted in 83% and 80% patients respectively...
1995: Roczniki Akademii Medycznej W Białymstoku, Annales Academiae Medicae Bialostocensis
V Saggese, G Zanda
No abstract text is available yet for this article.
June 16, 1974: Minerva Pediatrica
J C Minet, M Delire, J Clotuche, J P de Monnoye
A comparative study on the course of bacteremia and the postoperative behavior in 132 patients requiring tonsillectomy and adenoidectomy has been conducted. A control group including 33 patients was compared to three groups of an even number of cases treated with either doxycycline or amoxycyllin, or receiving gamma globulin immunotheraphy. Choice was guided by (1) the occurrence of bacteremia during surgery and the search for the various microbial strains involved, and (2) the confirmation of the advantages of the drug used within the first week of treatment...
1978: Acta Oto-rhino-laryngologica Belgica
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