A Ghodsizad, M Niehaus, G Kögler, U Martin, P Wernet, C Bara, N Khaladj, A Loos, M Makoui, J Thiele, M Mengel, M Karck, H M Klein, A Haverich, A Ruhparwar
OBJECTIVE: Functional improvement after acute myocardial ischaemia (MI) has been achieved by transplantation of different adult stem and progenitor cell types. It is controversial whether these cell types are able to form novel functional myocardium. Alternatively, graft-related or immune-related paracrine mechanisms may preserve existing myocardium, improve neovascularisation, affect tissue remodelling or induce endogenous de novo formation of functional myocardium. We have applied an alternative somatic cell type, human cord-blood-derived unrestricted somatic stem cells (USSCs) in a porcine model of acute MI...
January 2009: Heart: Official Journal of the British Cardiac Society