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https://www.readbyqxmd.com/read/29452400/sleep-quality-in-well-defined-lyme-disease-a-clinical-cohort-study-in-maryland
#1
Eric R Weinstein, Alison W Rebman, John N Aucott, Doug Johnson-Greene, Kathleen T Bechtold
Study Objectives: Lyme disease (LD) is the most common vector-borne disease in the United States. Approximately 5-15% of patients develop post-antibiotic treatment symptoms termed post-treatment LD syndrome (PTLDS). The primary objective of this study was to examine and quantify sleep quality among patients with early Lyme disease during the acute and convalescent periods, including among the subset who met criteria for PTLDS. Methods: This paper draws from a clinical cohort study of early LD participants (n=122) and a sub-cohort of individuals who later met criteria for PTLDS (n=6)...
February 14, 2018: Sleep
https://www.readbyqxmd.com/read/29452296/development-and-persistence-of-suspected-neuropathic-pain-after-total-knee-arthroplasty-in-individuals-with-osteoarthritis
#2
Matthew Fitzsimmons, Eloise Carr, Linda Woodhouse, Geoff P Bostick
BACKGROUND: Despite the effectiveness of total knee arthroplasty (TKA) for osteoarthritis (OA), up to 20% will report knee pain 1-year after surgery. One possible reason is the development of neuropathic pain before or after TKA. OBJECTIVE: To longitudinally describe suspected neuropathic pain in patients pre- and post-TKA and to explore relationships between pre-TKA suspected neuropathic pain and post-TKA outcomes. DESIGN: Prospective observational study...
February 13, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29452226/quantitative-proteomic-analysis-reveals-synaptic-dysfunction-in-the-amygdala-of-rats-susceptible-to-chronic-mild-stress
#3
Mi Zhou, Zhao Liu, Jia Yu, Shuiming Li, Min Tang, Li Zeng, Haiyang Wang, Hong Xie, Li Peng, Haojun Huang, Chanjuan Zhou, Peng Xie, Jian Zhou
The amygdala plays a key role in the pathophysiology of depression, but the molecular mechanisms underlying amygdalar hyperactivity in depression remain unclear. In this study, we used a chronic mild stress (CMS) protocol to separate susceptible and insusceptible rat subgroups. Proteomes in the amygdalae were analyzed differentially across subgroups based on labeling with isobaric tags for relative and absolute quantitation (iTRAQ) combined with mass spectrometry. Of 2,562 quantified proteins, 102 were differentially expressed...
February 13, 2018: Neuroscience
https://www.readbyqxmd.com/read/29452219/increased-cd4-counts-pain-and-depression-are-correlates-of-lower-sleep-quality-in-treated-hiv-positive-patients-with-low-baseline-cd4-counts
#4
K N Redman, A S Karstaedt, K Scheuermaier
Poor sleep quality leads to increased immune activation and immune activation leads to worse sleep quality. South African HIV positive patients typically have delayed start of treatment, which has been associated with CD4+ effector T cells being more spontaneously activated in chronically treated patients. This cross-sectional study investigated whether subjective sleep quality was associated with CD4+ T lymphocyte reconstitution in treated South African HIV+ patients. One hundred and thirty-nine treated HIV+ patients (109 F, age average (SD)= 43 (9)) were recruited from Chris Hani Baragwanath Academic Hospital in Soweto, Johannesburg, South Africa...
February 13, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29452218/tnf%C3%AE-disrupts-blood-brain-barrier-integrity-to-maintain-prolonged-depressive-like-behavior-in-mice
#5
Yuyan Cheng, Sachi Desse, Ana Martinez, Ryan J Worthen, Richard S Jope, Eleonore Beurel
Recovery from major depressive disorder is difficult, particularly in patients who are refractory to antidepressant treatments. To examine factors that regulate recovery, we developed a prolonged learned helplessness depression model in mice. After the induction of learned helplessness, mice were separated into groups that recovered or did not recover within 4 weeks. Comparisons were made between groups in hippocampal proteins, inflammatory cytokines, and blood brain barrier (BBB) permeability. Compared with mice that recovered and control mice, non-recovered mice displaying prolonged learned helplessness had greater hippocampal activation of glycogen synthase kinase-3 (GSK3), higher levels of tumor necrosis factor-α (TNFα), interleukin-17A, and interleukin-23, increased permeability of the blood brain barrier (BBB), and lower levels of the BBB tight junction proteins occludin, ZO1, and claudin-5...
February 13, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29452193/antidepressant-activity-of-vorinostat-is-associated-with-amelioration-of-oxidative-stress-and-inflammation-in-a-corticosterone-induced-chronic-stress-model-in-mice
#6
Athira Kv, Rajaram Mohanrao Madhana, Indu Chandran Js, Mangala Lahkar, Swapnil Sinha, V G M Naidu
Major depressive disorder (MDD) is a multifactorial neuropsychiatric disorder. Chronic administration of corticosterone (CORT) to rodents is used to mimic the stress associated dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, a well-established feature found in depressive patients. Recently, preclinical studies have demonstrated the antidepressant potential of histone deacetylase (HDAC) inhibitors. So, we examined the antidepressant potential of vorinostat (VOR), a HDAC inhibitor against CORT injections in male mice...
February 13, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29452113/technological-innovation-strategies-for-the-specific-treatment-of-chagas-disease-based-on-benznidazole
#7
REVIEW
Leslie Raphael de Moura Ferraz, Alinne Élida Gonçalves Alves, Débora Dolores Souza da Silva Nascimento, Isabela Araújo E Amariz, Aline Silva Ferreira, Salvana Priscylla Manso Costa, Larissa Araújo Rolim, Ádley Antonini Neves de Lima, Pedro José Rolim Neto
Caused by Trypanosoma cruzi, Chagas disease is responsible for public health problems greater in magnitude than those attributed to malaria, schistosomiasis, or leishmaniasis. A factor in the socioeconomic development of poor countries, Chagas disease can cause death due to a high parasitic burden during its acute phase due and irreversible damage in organs such as the heart, esophagus, and colon during its chronic phase, even when the number of parasites is minimal. For treating Chagas disease, benznidazole (BNZ) remains the drug of choice and, in Latin America, the only drug on the market for treating the disease...
February 13, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29452042/real-life-closeness-of-social-media-contacts-and-depressive-symptoms-among-university-students
#8
Ariel Shensa, Jaime E Sidani, César G Escobar-Viera, Kar-Hai Chu, Nicholas D Bowman, Jennifer M Knight, Brian A Primack
OBJECTIVE: To examine the association between degree of real-life closeness of social media (SM) contacts and depressive symptoms. PARTICIPANTS: Students ages 18-30 (N = 1124) were recruited in August 2016. METHODS: Participants completed an online survey assessing SM use and depression. We used multivariable logistic regression to assess associations between real-life closeness of SM contacts and depressive symptoms. RESULTS: After controlling for covariates, each 10% increase in the proportion of SM friends with whom participants had no face-to-face relationship was associated with a 9% increase in odds of depressive symptoms (AOR = 1...
February 16, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29452000/optimal-items-for-assessing-sluggish-cognitive-tempo-in-children-across-mother-father-and-teacher-ratings
#9
Belén Sáez, Mateu Servera, Stephen P Becker, G Leonard Burns
A recent meta-analysis identified optimal items for assessing sluggish cognitive tempo (SCT) as distinct from attention deficit/hyperactivity disorder inattention (ADHD-IN), and a preliminary study with teacher ratings of children in the United States found strong support for the convergent and discriminant validity of 15 SCT items. The current study evaluated whether the same 15 SCT items demonstrated convergent and discriminant validity from ADHD-IN in a large, community-based sample of children in Spain, and whether validity results were replicated across mother, father, and teacher ratings...
February 16, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29451967/cognitive-behavioral-therapy-for-anxiety-and-related-disorders-a-meta-analysis-of-randomized-placebo-controlled-trials
#10
REVIEW
Joseph K Carpenter, Leigh A Andrews, Sara M Witcraft, Mark B Powers, Jasper A J Smits, Stefan G Hofmann
The purpose of this study was to examine the efficacy of cognitive behavioral therapy (CBT) for anxiety-related disorders based on randomized placebo-controlled trials. We included 41 studies that randomly assigned patients (N = 2,843) with acute stress disorder, generalized anxiety disorder (GAD), obsessive compulsive disorder (OCD), panic disorder (PD), posttraumatic stress disorder (PTSD), or social anxiety disorder (SAD) to CBT or a psychological or pill placebo condition. Findings demonstrated moderate placebo-controlled effects of CBT on target disorder symptoms (Hedges' g = 0...
February 16, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29451948/duration-of-maternal-mental-health-related-outcomes-after-an-infant-s-death-a-retrospective-matched-cohort-study-using-linkable-administrative-data
#11
Elizabeth Wall-Wieler, Leslie L Roos, James Bolton
BACKGROUND: Mothers have increased mental illness such as anxiety and depression after the death of a child. We examine the duration of this worsening of mental health. METHODS: The mental health of all mothers who experience the death of an infant (< 1 years old) in Manitoba, Canada between April 1, 1999 and March 31, 2011 (n = 534) is examined in the 4 years leading up to, and the 4 years following, the death of their child. Mental health-related outcomes of these mothers are compared with a matched (3:1) cohort of mothers who did not experience the death of a child (n = 1,602)...
February 16, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29451933/depressive-symptoms-and-physical-frailty-in-older-adults-with-chronic-heart-failure-a-cross-sectional-study
#12
Youn-Jung Son, Eun Ji Seo
Depressive symptoms and physical frailty have been reported to be predictive of adverse outcomes in individuals with heart failure (HF). Depressive symptoms could be a predisposing factor of physical frailty in older adults. Despite the high prevalence of HF, few studies on the relationship between these two factors have been performed in older adults with HF. To identify the relationship between depressive symptoms and physical frailty in HF, 190 older adults with HF were recruited from an outpatient clinic at a tertiary hospital in South Korea...
February 13, 2018: Research in Gerontological Nursing
https://www.readbyqxmd.com/read/29451880/apolipoprotein-e-genotype-does-not-moderate-the-associations-of-depressive-symptoms-neuroticism-and-allostatic-load-with-cognitive-ability-and-cognitive-aging-in-the-lothian-birth-cohort-1936
#13
Zander Crook, Tom Booth, Simon R Cox, Janie Corley, Dominika Dykiert, Paul Redmond, Alison Pattie, Adele M Taylor, Sarah E Harris, John M Starr, Ian J Deary
OBJECTIVES: In this replication-and-extension study, we tested whether depressive symptoms, neuroticism, and allostatic load (multisystem physiological dysregulation) were related to lower baseline cognitive ability and greater subsequent cognitive decline in older adults, and whether these relationships were moderated by the E4 allele of the apolipoprotein E (APOE) gene. We also tested whether allostatic load mediated the relationships between neuroticism and cognitive outcomes. METHODS: We used data from the Lothian Birth Cohort 1936 (n at Waves 1-3: 1,028 [M age = 69...
2018: PloS One
https://www.readbyqxmd.com/read/29451835/characteristics-and-outcomes-of-advanced-cancer-patients-who-received-palliative-care-at-a-public-hospital-compared-with-those-at-a-comprehensive-cancer-center
#14
Marvin Omar Delgado-Guay, Jeannette Ferrer, Jewel Ochoa, Hilda Cantu, Janet L Williams, Minjeong Park, Eduardo Bruera
BACKGROUND: Patients with advanced cancer experience severe physical, psychosocial, and spiritual distress requiring palliative care (PC). There are limited literature regarding characteristics and outcomes of patients evaluated by PC services at public hospitals (PHs). Objective, Design, Setting/Subjects, and Measurements: To compare the outcomes of advanced cancer patients undergoing PC at a PH and those at a comprehensive cancer center (CCC). We reviewed 359 consecutive advanced cancer patients (PH, 180; CCC, 179) undergoing PC...
February 16, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29451831/high-dose-perinatal-folic-acid-supplementation-alters-insulin-sensitivity-in-sprague-dawley-rats-and-diminishes-the-expression-of-adiponectin
#15
Ayodele Olufemi Morakinyo, Titilola Aderonke Samuel, Funmileyi Olubajo Awobajo, Gabriel Olorunleke Oludare, Adekunle Mofolorunso
The possible intake of folate in excess of the recommended upper levels is a matter of critical importance. This study was conducted to investigate the effects of prenatal and postnatal high folic acid supplementation (FAS) on glucose tolerance, insulin sensitivity, lipid metabolism, and expression of adiponectin in rats. The study included 20 female rats divided into two groups: control group and FAS group (receiving high folic acid supplemented diet). Both groups of female rats were mated and pregnancy confirmed...
February 16, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29451821/protection-from-vascular-dysfunction-in-female-rats-with-chronic-stress-and-depressive-symptoms
#16
Steven D Brooks, Stan Hileman, Paul D Chantler, Samantha Milde, Kent C Lemaster, Stephanie Frisbee, J Kevin Shoemaker, Dwayne N Jackson, Jefferson C Frisbee
The increasing prevalence and severity of clinical depression is strongly correlated with vascular disease risk, creating a comorbid condition with poor outcomes, although demonstrating a sexual disparity where females are at lower risk than males for subsequent cardiovascular events. To determine potential mechanisms responsible for this protection against stress/depression-induced vasculopathy in females, we exposed male and female ({plus minus}ovariectomy) rats to the unpredictable chronic mild stress (UCMS) model for 8 weeks and determined depressive symptom severity, vascular reactivity in aortic rings (AR) and ex vivo middle cerebral arteries (MCA), and determined the profile of major metabolites regulating vascular tone...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29451819/protection-from-chronic-stress-and-depressive-symptom-induced-vascular-endothelial-dysfunction-in-female-rats-is-abolished-by-pre-existing-metabolic-disease
#17
Steven D Brooks, Stan Hileman, Paul D Chantler, Samantha Milde, Kent C Lemaster, Stephanie Frisbee, J Kevin Shoemaker, Dwayne N Jackson, Jefferson C Frisbee
While it is known that chronic stress and clinical depression are powerful predictors of poor cardiovascular outcomes, recent clinical evidence has identified correlations between the development of metabolic disease and that for depressive symptoms; creating a combined condition of severely elevated cardiovascular disease risk. In this companion manuscript, we determine the impact of pre-existing metabolic disease on the relationship between chronic stress//depressive symptoms and vascular function, using the obese Zucker (OZR) and the unpredictable chronic mild stress UCMS models...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29451672/predictors-of-persistent-prescription-opioid-analgesic-use-among-people-without-cancer-in-australia
#18
Samanta Lalic, Natasa Gisev, J Simon Bell, Maarit Jaana Korhonen, Jenni Ilomäki
AIMS: To identify patterns of opioid analgesic use and determine predictors of persistent opioid use among people without cancer. METHODS: A population-based cohort study of Australians initiating prescription opioids from July 2013 to December 2015 was conducted using data from a random 10% sample of people who accessed medicines through Australia's Pharmaceutical Benefits Scheme. A 12-month look-back period was used to define opioid initiation, exclude people with cancer, and determine comorbidities...
February 16, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29451662/what-clinical-functional-and-psychological-factors-before-treatment-are-predictors-of-poor-quality-of-life-in-cancer-patients-at-the-end-of-chemotherapy
#19
Ariella Sebastião Mangia, Nara Lisiane de Oliveira Coqueiro, Fernanda Cabral Azevedo, Hiago Tomaz da Silva Araujo, Elizandra de Oliveira Amorim, Cibelli Navarro Rodrigues Alves, Calvino Camargo, Allex Jardim da Fonseca
OBJECTIVE: To correlate physical activity level (PAL), functional capacity and psychological state with quality of life (QoL) in cancer patients undergoing chemotherapy (CT). METHOD: Observational cohort study. Patients (n=121) with any primary cancer site with indications of chemotherapy with palliative or curative intent were evaluated at three moments: 1) patient admission (week 0), before chemotherapy; 2) week 8; 3) end of CT. Data were collected regarding QoL, PAL, clinical data, functional capacity (short walking distance test, sitting-rising test, isometric manual gripping force), and anxiety and depression tests...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29451588/religiosity-depression-and-quality-of-life-in-bipolar-disorder-a-two-year-prospective-study
#20
André Stroppa, Fernando A Colugnati, Harold G Koenig, Alexander Moreira-Almeida
OBJECTIVE: Few quantitative studies have examined the effect of religious involvement on the course of bipolar disorder (BD). We investigated the effects of religious activity and coping behaviors on the course of depression, mania, and quality of life (QoL) in patients with BD. METHODS: Two-year longitudinal study of 168 outpatients with BD. Linear regression was used to examine associations between religious predictors and outcome variables (manic symptoms, depression, QoL), controlling for sociodemographic variables...
February 15, 2018: Revista Brasileira de Psiquiatria
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