keyword
MENU ▼
Read by QxMD icon Read
search

Oligodendrocyte precursor cell

keyword
https://www.readbyqxmd.com/read/29244098/clemastine-rescues-myelination-defects-and-promotes-functional-recovery-in-hypoxic-brain-injury
#1
Bruce A C Cree, Jianqin Niu, Kimberly K Hoi, Chao Zhao, Scott D Caganap, Roland G Henry, Dang Q Dao, Daniel R Zollinger, Feng Mei, Yun-An A Shen, Robin J M Franklin, Erik M Ullian, Lan Xiao, Jonah R Chan, Stephen P J Fancy
Hypoxia can injure brain white matter tracts, comprised of axons and myelinating oligodendrocytes, leading to cerebral palsy in neonates and delayed post-hypoxic leukoencephalopathy (DPHL) in adults. In these conditions, white matter injury can be followed by myelin regeneration, but myelination often fails and is a significant contributor to fixed demyelinated lesions, with ensuing permanent neurological injury. Non-myelinating oligodendrocyte precursor cells are often found in lesions in plentiful numbers, but fail to mature, suggesting oligodendrocyte precursor cell differentiation arrest as a critical contributor to failed myelination in hypoxia...
December 13, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29239330/expression-of-ng2-and-platelet-derived-growth-factor-receptor-alpha-in-the-developing-neonatal-rat-brain
#2
Ping Li, Heng-Xi Li, Hong-Yan Jiang, Lie Zhu, Hai-Ying Wu, Jin-Tao Li, Jiang-Hua Lai
Platelet-derived growth factor receptor alpha (PDGFRα) is a marker of oligodendrocyte precursor cells in the central nervous system. NG2 is also considered a marker of oligodendrocyte precursor cells. However, whether there are differences in the distribution and morphology of oligodendrocyte precursor cells labeled by NG2 or PDGFRα in the developing neonatal rat brain remains unclear. In this study, by immunohistochemical staining, NG2 positive (NG2+) cells were ubiquitous in the molecular layer, external pyramidal layer, internal pyramidal layer, and polymorphic layer of the cerebral cortex, and corpus callosum, external capsule, piriform cortex, and medial septal nucleus...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29216327/protamine-neutralizes-chondroitin-sulfate-proteoglycan-mediated-inhibition-of-oligodendrocyte-differentiation
#3
Kazuya Kuboyama, Naomi Tanga, Ryoko Suzuki, Akihiro Fujikawa, Masaharu Noda
Chondroitin sulfate proteoglycans (CSPGs), which are enriched in demyelinating plaques in neurodegenerative diseases, such as multiple sclerosis (MS), impair remyelination by inhibiting the migration and differentiation of oligodendrocyte precursor cells (OPCs) in the central nervous system (CNS). We herein show that protamine (PRM, also known as a heparin antagonist) effectively neutralizes the inhibitory activities of CSPGs, thereby enhancing OPC differentiation and (re)myelination in mice. Cell-based assays using mouse OPC-like OL1 cells revealed that the PRM treatment exerted masking effects on extracellular CSPGs and improved oligodendrocyte differentiation on inhibitory CSPG-coated substrates...
2017: PloS One
https://www.readbyqxmd.com/read/29205833/monocarboxylate-transporter-1-and-the-vulnerability-of-oligodendrocyte-lineage-cells-to-metabolic-stresses
#4
Peng Zhou, Teng Guan, Zhao Jiang, Mike Namaka, Qing-Jun Huang, Ji-Ming Kong
AIMS: Oligodendrocytes, especially oligodendrocyte precursor cells, are known to be sensitive to hypoxic and metabolic stresses. Vulnerability of oligodendrocytes is considered a contributing factor to white matter dysfunction. However, little is known about the energy processing characteristics of oligodendrocyte lineage cells under basal and metabolic stress conditions. The aim of this study was to identify the energy requirements and cellular responses of oligodendrocytes at different developmental stages...
December 4, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29202778/regulator-of-oligodendrocyte-maturation-mir-219-a-potential-biomarker-for-ms
#5
Ilona B Bruinsma, Marie van Dijk, Claire Bridel, Timothy van de Lisdonk, Sanne Q Haverkort, Tessel F Runia, Lawrence Steinman, Rogier Q Hintzen, Joep Killestein, Marcel M Verbeek, Charlotte E Teunissen, Brigit A de Jong
BACKGROUND: Multiple sclerosis (MS) is a demyelinating and degenerative disease of the central nervous system. Normally, demyelination is followed by remyelination, which requires repopulation of a demyelinated area by oligodendrocyte precursor cells. Although large numbers of precursor cells are present in MS lesions, remyelination often fails, in part by the inability of precursor cells to differentiate into mature myelin-forming cells. In mouse and rat, miR-219 is required for this differentiation...
December 4, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29175488/influence-of-the-epileptiform-discharge-microenvironment-on-the-differentiation-of-oligodendrocyte-precursor-cells
#6
Yue Wang, Liming Liu, Hengsheng Chen, Li Cheng, Li Jiang
The use of related cell cultured models to investigate the genesis and development of epilepsy is beneficial for exploring the mechanism of epileptogenesis. Recent reports have described the myelination damage caused by epilepsy in animal models; however, limited reports have focused on the influence of epilepsy on remyelination in vitro. The current study was designed to investigate the effect of the epileptiform discharge microenvironment on the differentiation of oligodendrocyte precursor cells (OPCs). Neurons with epileptiform discharge released more glutamic acid than normal neurons, which was detected by HPLC...
November 23, 2017: Brain Research
https://www.readbyqxmd.com/read/29171439/effect-of-glial-cells-on-remyelination-after-spinal-cord-injury
#7
REVIEW
Hai-Feng Wang, Xing-Kai Liu, Rui Li, Ping Zhang, Ze Chu, Chun-Li Wang, Hua-Rui Liu, Jun Qi, Guo-Yue Lv, Guang-Yi Wang, Bin Liu, Yan Li, Yuan-Yi Wang
Remyelination plays a key role in functional recovery of axons after spinal cord injury. Glial cells are the most abundant cells in the central nervous system. When spinal cord injury occurs, many glial cells at the lesion site are immediately activated, and different cells differentially affect inflammatory reactions after injury. In this review, we aim to discuss the core role of oligodendrocyte precursor cells and crosstalk with the rest of glia and their subcategories in the remyelination process. Activated astrocytes influence proliferation, differentiation, and maturation of oligodendrocyte precursor cells, while activated microglia alter remyelination by regulating the inflammatory reaction after spinal cord injury...
October 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29167725/transdifferentiation-of-human-dental-pulp-stem-cells-into-oligoprogenitor-cells
#8
Ardeshir Moayeri, Maryam Nazm Bojnordi, Sara Haratizadeh, Amir Esmaeilnejad-Moghadam, Rafieh Alizadeh, Hatef Ghasemi Hamidabadi
Introduction: The nerve fibers in central nervous system are surrounded by myelin sheet which is formed by oligodendrocytes. Cell therapy based on oligodendrocytes and their precursors transplantation can hold a promising alternative treatment for myelin sheet repair in demyelinating diseases. Methods: Human Dental Pulp Stem Cells (hDPSCs) are noninvasive, autologous and easy available source with multipotency characteristics, so they are in focus of interest in regenerative medicine...
September 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/29162133/humoral-response-in-experimental-autoimmune-encephalomyelitis-targets-neural-precursor-cells-in-the-central-nervous-system-of-naive-rodents
#9
Evangelia Kesidou, Olga Touloumi, Roza Lagoudaki, Evangelia Nousiopoulou, Paschalis Theotokis, Kyriaki-Nepheli Poulatsidou, Marina Boziki, Evangelia Kofidou, Nickoleta Delivanoglou, Fani Minti, Georgios Hadjigeorgiou, Nikolaos Grigoriadis, Constantina Simeonidou
BACKGROUND: Neural precursor cells (NPCs) located in the subventricular zone (SVZ), a well-defined NPC niche, play a crucial role in central nervous system (CNS) homeostasis. Moreover, NPCs are involved in the endogenous reparative process both in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). However, the possibility that NPCs may be vulnerable to immune-related components may not be ruled out. Therefore, we investigated the potential affinity of myelin oligodendrocyte glycoprotein (MOG)-induced humoral response(s) to NPCs...
November 21, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29161318/loss-of-mtorc2-signaling-in-oligodendrocyte-precursor-cells-delays-myelination
#10
Mark D Grier, Kathryn L West, Nathaniel D Kelm, Cary Fu, Mark D Does, Brittany Parker, Eleanor McBrier, Andre H Lagrange, Kevin C Ess, Robert P Carson
Myelin abnormalities are increasingly being recognized as an important component of a number of neurologic developmental disorders. The integration of many signaling pathways and cell types are critical for correct myelinogenesis. The PI3-K and mechanistic target of rapamycin (mTOR) pathways have been found to play key roles. mTOR is found within two distinct complexes, mTORC1 and mTORC2. mTORC1 activity has been shown to play a major role during myelination, while the role of mTORC2 is not yet well understood...
2017: PloS One
https://www.readbyqxmd.com/read/29150274/neuroprotective-potential-of-high-dose-biotin
#11
Mark F McCarty, James J DiNicolantonio
A recent controlled trial has established that high-dose biotin supplementation - 100 mg, three times daily - has a stabilizing effect on progression of multiple sclerosis (MS). Although this effect has been attributed to an optimization of biotin's essential cofactor role in the brain, a case can be made that direct stimulation of soluble guanylate cyclase (sGC) by pharmacological concentrations of biotin plays a key role in this regard. The utility of high-dose biotin in MS might reflect an anti-inflammatory effect of cGMP on the cerebral microvasculature, as well on oligodendrocyte differentiation and on Schwann cell production of neurotrophic factors thought to have potential for managing MS...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29148104/neuregulin-1-promotes-remyelination-and-fosters-a-pro-regenerative-inflammatory-response-in-focal-demyelinating-lesions-of-the-spinal-cord
#12
Hardeep Kataria, Arsalan Alizadeh, Ghazaleh M Shahriary, Shekoofeh Saboktakin Rizi, Ryan Henrie, Kallivalappil T Santhosh, James A Thliveris, Soheila Karimi-Abdolrezaee
Oligodendroglial cell death and demyelination are hallmarks of neurotrauma and multiple sclerosis that cause axonal damage and functional impairments. Remyelination remains a challenge as the ability of endogenous precursor cells for oligodendrocyte replacement is hindered in the unfavorable milieu of demyelinating conditions. Here, in a rat model of lysolecithin lysophosphatidyl-choline (LPC)-induced focal demyelination, we report that Neuregulin-1 (Nrg-1), an important factor for oligodendrocytes and myelination, is dysregulated in demyelinating lesions and its bio-availability can promote oligodendrogenesis and remyelination...
November 17, 2017: Glia
https://www.readbyqxmd.com/read/29141824/inhibition-of-neurogenesis-in-a-case-of-marburg-variant-multiple-sclerosis
#13
Celia Oreja-Guevara, Ulises Gómez-Pinedo, Julia García-López, Rafael Sánchez-Sánchez, Roberto Valverde-Moyano, Alberto Rabano-Gutierrez, Jordi A Matías-Guiu, Ines González-Suárez, Jorge Matías-Guiu
INTRODUCTION: Neural stem cells (NSC) are located essentially in the subventricular zone (SVZ), subgranular zone (SGZ), and along the central canal of the spinal cord. These cells can proliferate in vitro and differentiate into neurons, oligodendrocytes, and astroglia, thus contributing to repair in multiple sclerosis (MS). We conducted a pathological study to analyse neurogenic response in a patient with Marburg variant MS. METHODS: We present the case of a 27-year-old immunocompetent patient with Marburg variant MS, a fulminant form of the disease...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29134703/origin-and-dynamics-of-oligodendrocytes-in-the-developing-brain-implications-for-perinatal-white-matter-injury
#14
REVIEW
Erik van Tilborg, Caroline G M de Theije, Maurik van Hal, Nienke Wagenaar, Linda S de Vries, Manon J Benders, David H Rowitch, Cora H Nijboer
Infants born prematurely are at high risk to develop white matter injury (WMI), due to exposure to hypoxic and/or inflammatory insults. Such perinatal insults negatively impact the maturation of oligodendrocytes (OLs), thereby causing deficits in myelination. To elucidate the precise pathophysiology underlying perinatal WMI, it is essential to fully understand the cellular mechanisms contributing to healthy/normal white matter development. OLs are responsible for myelination of axons. During brain development, OLs are generally derived from neuroepithelial zones, where neural stem cells committed to the OL lineage differentiate into OL precursor cells (OPCs)...
November 14, 2017: Glia
https://www.readbyqxmd.com/read/29133394/role-of-estrogen-receptor-beta-in-neural-differentiation-of-mouse-embryonic-stem-cells
#15
Mukesh K Varshney, José Inzunza, Diana Lupu, Vaidheeswaran Ganapathy, Per Antonson, Joëlle Rüegg, Ivan Nalvarte, Jan-Åke Gustafsson
The ability to propagate mature cells and tissue from pluripotent stem cells offers enormous promise for treating many diseases, including neurodegenerative diseases. Before such cells can be used successfully in neurodegenerative diseases without causing unwanted cell growth and migration, genes regulating growth and migration of neural stem cells need to be well characterized. Estrogen receptor beta (ERβ) is essential for migration of neurons and glial cells in the developing mouse brain. To examine whether ERβ influences differentiation of mouse embryonic stem cells (mESC) into neural lineages, we compared control and ERβ knockout (BERKO) mESCs at defined stages of neural development and examined the effects of an ERβ-selective ligand (LY3201) with a combination of global and targeted gene-expression profiling and the expression of key pluripotency markers...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29131145/metabolomics-based-discovery-of-a-metabolite-that-enhances-oligodendrocyte-maturation
#16
Brittney A Beyer, Mingliang Fang, Benjamin Sadrian, J Rafael Montenegro-Burke, Warren C Plaisted, Bernard P C Kok, Enrique Saez, Toru Kondo, Gary Siuzdak, Luke L Lairson
Endogenous metabolites play essential roles in the regulation of cellular identity and activity. Here we have investigated the process of oligodendrocyte precursor cell (OPC) differentiation, a process that becomes limiting during progressive stages of demyelinating diseases, including multiple sclerosis, using mass-spectrometry-based metabolomics. Levels of taurine, an aminosulfonic acid possessing pleotropic biological activities and broad tissue distribution properties, were found to be significantly elevated (∼20-fold) during the course of oligodendrocyte differentiation and maturation...
November 13, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/29126910/impaired-oligodendrogenesis-and-myelination-by-elevated-s100b-levels-during-neurodevelopment
#17
Gisela Santos, Andreia Barateiro, Cláudio M Gomes, Dora Brites, Adelaide Fernandes
High levels of the inflammatory molecule S100B protein have been identified in sera from several perinatal inflammatory conditions involving myelin damage and associated with an adverse prognosis or the emergence of sequelea. S100B is essential for oligodendrocyte (OL) differentiation and maturation, but it remains to be established if excessive levels of released S100B upon early brain injury are deleterious in the neurodevelopmental period. Here, we investigated this possibility by evaluating how elevated S100B affects oligodendrogenesis during this period...
November 8, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29126015/single-cell-transcriptomic-analysis-of-oligodendrocyte-lineage-cells
#18
REVIEW
David van Bruggen, Eneritz Agirre, Gonçalo Castelo-Branco
Oligodendrocytes (OLs) are glial cells in the central nervous system (CNS), which produce myelin, a lipid-rich membrane that insulates neuronal axons. The main function ascribed to OLs is to regulate the speed of electric pulse transmission, and as such OLs have been widely considered as a single and discrete population. Nevertheless, OLs and their precursor cells (OPCs) throughout the CNS have different morphologies and regional functional differences have been observed. Moreover, OLs have recently been involved in other functional processes such as metabolic coupling with axons...
November 7, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29123527/erythropoietin-increases-myelination-in-oligodendrocytes-gene-expression-profiling-reveals-early-induction-of-genes-involved-in-lipid-transport-and-metabolism
#19
Georgina Gyetvai, Trisha Hughes, Florence Wedmore, Cieron Roe, Lamia Heikal, Pietro Ghezzi, Manuela Mengozzi
Several studies have shown that erythropoietin (EPO) has neuroprotective or neuroreparative actions on diseases of the nervous system and that improves oligodendrocyte (OL) differentiation and myelination in vivo and in vitro. This study aims at investigating the early molecular mechanisms for the pro-myelinating action of EPO at the gene expression level. For this purpose, we used a differentiating OL precursor cell line, rat central glia-4 cells. Cells were differentiated or not, and then treated with EPO for 1 or 20 h...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29122585/strong-sonic-hedgehog-signaling-in-the-mouse-ventral-spinal-cord-is-not-required-for-oligodendrocyte-precursor-cell-opc-generation-but-is-necessary-for-correct-timing-of-its-generation
#20
Hirokazu Hashimoto, Wen Jiang, Takeshi Yoshimura, Kyeong-Hye Moon, Jinwoong Bok, Kazuhiro Ikenaka
In the mouse neural tube, sonic hedgehog (Shh) secreted from the floor plate (FP) and the notochord (NC) regulates ventral patterning of the neural tube, and later is essential for the generation of oligodendrocyte precursor cells (OPCs). During early development, the NC is adjacent to the neural tube and induces ventral domains in it, including the FP. In the later stage of development, during gliogenesis in the spinal cord, the pMN domain receives strong Shh signaling input. While this is considered to be essential for the generation of OPCs, the actual role of this strong input in OPC generation remains unclear...
November 6, 2017: Neurochemistry International
keyword
keyword
80456
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"