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sinonasal cancer

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https://www.readbyqxmd.com/read/29240044/sinonasal-cancer-in-a-worker-exposed-to-chromium-in-an-unusual-industrial-sector
#1
Vera Comiati, Maria Luisa Scapellato, Enrico Alexandre, Tiziana Volo, Daniele Borsetto, Mariella Carrieri, Enzo Emanuelli, Diego Cazzador
BACKGROUND: Occupational exposure to chromium is carcinogenic for human respiratory system. Due to the low incidence of sinonasal malignancies, there is still a paucity of evidence to confirm that chromium(VI) exposure is a cause of nasal cancer. OBJECTIVES: To report on a sinonasal cancer (SNC) of rare occupational origin, increasing the awareness on epidemiological knowledge of occupational exposures to chromium compounds. METHODS: We describe a case of a 64-year-old chrome plater who worked in the galvanic industry in the early 1970s...
December 14, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29210531/comparison-of-endoscopic-and-open-resection-of-sinonasal-squamous-cell-carcinoma-a-propensity-score-matched-analysis-of-652-patients
#2
Suat Kılıç, Sarah S Kılıç, Soly Baredes, Richard Chan Woo Park, Omar Mahmoud, Jeffrey D Suh, Stacey T Gray, Jean Anderson Eloy
BACKGROUND: The use of endoscopic resection as an alternative to open surgery for sinonasal malignancies has increased in the past 20 years. METHODS: The National Cancer Database was queried for cases of sinonasal squamous cell carcinoma (SNSCC) without cervical or distant metastases that were treated surgically between 2010 and 2014. They were split into 2 groups based on surgical approach: open or endoscopic. Demographics, facility and insurance type, stage, tumor characteristics, postoperative treatment, 30-day readmission rate, 30- and 90-day mortality, and overall survival (OS) were compared between the 2 groups...
December 6, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29193098/factors-associated-with-a-primary-surgical-approach-for-sinonasal-squamous-cell-carcinoma
#3
Jennifer R Cracchiolo, Krupa Patel, Jocelyn C Migliacci, Luc T Morris, Ian Ganly, Benjamin R Roman, Sean M McBride, Viviane S Tabar, Marc A Cohen
BACKGROUND AND OBJECTIVES: Primary surgery is the preferred treatment of T1-T4a sinonasal squamous cell carcinoma (SNSCC). METHODS: Patients with SNSCC in the National Cancer Data Base (NCDB) were analyzed. Factors that contributed to selecting primary surgical treatment were examined. Overall survival (OS) in surgical patients was analyzed. RESULTS: Four-thousand seven hundred and seventy patients with SNSCC were included. In T1-T4a tumors, lymph node metastases, maxillary sinus location, and treatment at high-volume centers were associated with selecting primary surgery...
November 28, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29142805/role-of-adjuvant-treatment-in-sinonasal-mucosal-melanoma
#4
Moran Amit, Samantha Tam, Ahmed S Abdelmeguid, Michael E Kupferman, Shirley Y Su, Shaan M Raza, Franco DeMonte, Ehab Y Hanna
Purpose  Sinonasal mucosal melanoma (SNMM) is a locally aggressive tumor. This study aimed to define the role of adjuvant treatment and its association with survival outcomes of SNMM. Methods  This retrospective study investigated 152 patients with SNMM treated between 1991 and 2016 in MD Anderson Cancer Center. Patients were divided into the following treatment groups: surgery alone, surgery with postoperative radiotherapy (PORT), surgery with postoperative chemoradiation (POCRT), and induction chemotherapy followed by surgery and PORT...
December 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29114957/sinonasal-cancer-in-the-italian-national-surveillance-system-epidemiology-occupation-and-public-health-implications
#5
Alessandra Binazzi, Marisa Corfiati, Davide Di Marzio, Anna M Cacciatore, Jana Zajacovà, Carolina Mensi, Paolo Galli, Lucia Miligi, Roberto Calisti, Elisa Romeo, Alessandro Franchi, Alessandro Marinaccio
BACKGROUND: Sinonasal cancer (SNC) is a rare tumor with predominant occupational etiology associated with exposures to specific carcinogens. The aim of this study is to describe SNC cases recorded in Italy in the period 2000-2016. METHODS: Clinical information, occupational history, and lifestyle habits of SNC cases collected in the Italian Sinonasal Cancer Register were examined. Age-standardized rates were estimated. RESULTS: Overall, 1529 cases were recorded...
November 7, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29104720/dasatinib-induced-seborrheic-dermatitis-like-eruption
#6
Ryan R Riahi, Philip R Cohen
Dasatinib is an oral tyrosine kinase inhibitor approved for imatinib-resistant chronic myelogenous leukemia. It has been investigated in treating other neoplasms, including non-small-cell lung cancer and a subset of melanomas. Seborrheic dermatitis is characterized by erythematous patches or plaques with scaling typically affecting the external ear, glabella, hair-bearing areas of the face, nasolabial fold, and scalp. Antitumor agents are often associated with mucocutaneous side effects, including seborrheic dermatitis...
July 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29095708/updates-in-the-management-of-sinonasal-mucosal-melanoma
#7
Meghan M Crippen, Suat Kılıç, Jean A Eloy
PURPOSE OF REVIEW: Sinonasal mucosal melanoma (SNMM) is an aggressive cancer with a poor prognosis. Although there is significant study surrounding the treatment of sinonasal malignancies and cutaneous melanomas, the rarity of this tumor has largely precluded robust outcomes analyses. The authors of this review seek to provide an overview of the recent literature related to the treatment of SNMM with added context from our institutional experience with this disease. RECENT FINDINGS: In the surgical management of sinonasal malignancies and SNMM specifically, resection via endoscopic endonasal technique appears to offer comparable oncologic outcomes versus an open approach...
October 31, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29083507/complications-and-donor-site-morbidity-of-3-layer-reconstruction-with-iliotibial-tract-of-the-anterior-skull-base-retrospective-analysis-of-186-patients
#8
Davide Mattavelli, Alberto Schreiber, Andrea Bolzoni Villaret, Remo Accorona, Mario Turri-Zanoni, Alessia Lambertoni, Marco Ferrari, Paolo Castelnuovo, Piero Nicolai
BACKGROUND: Anterior skull base reconstruction after resection of sinonasal cancers may be challenging when pedicled flaps are unavailable. The purpose of the present study was to analyze the complication rate and donor site morbidity of 3-layer reconstruction with the iliotibial tract (ITT). METHODS: We retrospectively reviewed all anterior skull base reconstructions with ITT performed from 2007 to 2015. Donor site morbidity was investigated by a dedicated questionnaire...
October 30, 2017: Head & Neck
https://www.readbyqxmd.com/read/29079177/sinonasal-nut-carcinoma-clinicopathological-and-cytogenetic-analysis-with-autopsy-findings
#9
Hiroshi Minato, Eriko Kobayashi, Satoko Nakada, Nozomu Kurose, Mio Tanaka, Yukichi Tanaka, Shioto Suzuki, Fumihiko Tanioka, Yutaka Saikawa, Takaki Miwa, Takayuki Nojima
Nuclear protein in testis (NUT) carcinoma is a rare malignant neoplasm with an undifferentiated morphology. Its diagnosis is often difficult, especially as the sinonasal tract gives rise to many tumors with undifferentiated morphologies. Not many cases of sinonasal NUT carcinomas have been reported, and its clinicopathological features have not been sufficiently clarified. In this study, we performed a clinicopathological study of 4 patients with sinonasal NUT carcinoma, including wide-ranging immunohistochemical tests and cytogenetic analyses using fluorescence in situ hybridization and DNA sequencing...
October 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/29075744/multidisciplinary-clinic-management-of-head-and-neck-cancer
#10
Melanie Townsend, Dorina Kallogjeri, Nicholas Scott-Wittenborn, Katherine Gerull, Stacy Jansen, Brian Nussenbaum
Importance: Contemporary management of head and neck cancer involves professionals from multiple specializations. Streamlined care that reduces delays yet allows for comprehensive evaluation is needed. Objective: To evaluate a single-day, single-appointment, multidisciplinary head and neck clinic model for reduction in treatment delay and comprehensiveness of care. Design, Setting, and Participants: A retrospective cohort analysis was conducted from June 1, 2015, to July 31, 2016, of outpatients at a single, academic medical center...
October 26, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29056464/a-population-based-comparison-of-european-and-north-american-sinonasal-cancer-survival
#11
Aykut A Unsal, Suat Kılıç, Pariket M Dubal, Soly Baredes, Jean Anderson Eloy
OBJECTIVE: Sinonasal cancers (SNC) are rare, thus limiting previous prognostic studies on a multinational level. The aim of this study is to utilize two population-based datasets to compare prognoses for SNC between the United States (US) and Europe. METHODS: The European Cancer Registry (EUROCARE) database and the United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database were searched to identify survival of patients diagnosed with SNC between 1990 and 2007...
October 19, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29049462/association-of-surgical-approach-and-margin-status-with-oncologic-outcomes-following-gross-total-resection-for-sinonasal-melanoma
#12
Zafar Sayed, Jocelyn C Migliacci, Jennifer R Cracchiolo, Christopher A Barker, Nancy Y Lee, Sean M McBride, Viviane S Tabar, Ian Ganly, Snehal G Patel, Luc T Morris, Benjamin R Roman, Alexander N Shoushtari, Marc A Cohen
Importance: Sinonasal mucosal melanoma (SMM) is a rare malignant neoplasm characterized by a poor prognosis despite aggressive intervention including wide surgical resection. Margin status has previously been cited as an important prognostic factor for local control and overall survival (OS) in patients who undergo either an open or endoscopic surgical approach. No comparisons have been made, however, in patients who have undergone gross total resection with or without positive margins...
October 19, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29044881/local-control-in-sinonasal-malignant-melanoma-comparing-conventional-to-hypofractionated-radiotherapy
#13
Jules Lansu, Willem Martin Klop, Wilma Heemsbergen, Arash Navran, Abrahim Al-Mamgani, Johannes A Langendijk, Johannes H Kaanders, Chris Terhaard, Baris Karakullukcu, Olga Hamming-Vrieze
BACKGROUND: The purpose of this study was to analyze the effect of fractionation schedule on local control in postoperative radiotherapy (RT) for sinonasal malignant melanoma. METHODS: Sixty-three patients who were treated with surgery and postoperative RT in 4 accredited head and neck cancer centers in the Netherlands between 1998 and 2013 were retrospectively studied. Outcomes with conventional fractionation (2-2.4 Gy per fraction; n = 27) were compared to hypofractionation (4-6 Gy per fraction; n = 36)...
October 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/29044491/approaches-to-regional-lymph-node-metastasis-in-patients-with-head-and-neck-mucosal-melanoma
#14
Moran Amit, Samantha Tam, Ahmed S Abdelmeguid, Dianna B Roberts, Shaan M Raza, Shirley Y Su, Michael E Kupferman, Franco DeMonte, Ehab Y Hanna
BACKGROUND: Mucosal melanomas in the head and neck region are most often located in the nasal cavity and paranasal sinuses. To the authors' knowledge, the prognostic effects of lymph node metastasis in patients with sinonasal mucosal melanoma (SNMM) have not been established. Therefore, the objective of the current study was to determine the effects of lymph node metastasis on survival. METHODS: The current study included 198 patients with SNMM who had been treated between 1985 and 2016 at The University of Texas MD Anderson Cancer Center in Houston...
October 17, 2017: Cancer
https://www.readbyqxmd.com/read/29040365/role-of-the-akt-mtor-signaling-pathway-in-human-papillomavirus-associated-nasal-and-sinonasal-inverted-papilloma
#15
Yongliang Liu, Lihua Duan, Jie Tian, Daoliang Song, Min Zhang, Shenlin Zhao, Zhaofu Yin, Xinxin Xiang, Xuezhong Li
Nasal and sinonasal inverted papilloma (NSIP) is a benign tumor in which surface epithelial cells grow downward into the underlying supportive tissue with varying degrees of metaplasia. Human papillomavirus (HPV) has been proposed as the causal agent in the pathogenesis of this disease. Many studies have shown that HPV can activate the Akt/mechanistic target of rapamycin (mTOR) signaling pathway, but the role of this pathway in HPV-associated NSIP is largely unknown. In this study, we enrolled 40 control tissue samples and 80 NSIP tissue samples...
October 13, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29034666/-respiratory-cancers-attributable-to-occupational-exposures-what-is-the-cost-to-society-in-france
#16
Hassan Serrier, Hélène Sultan-Taïeb, Danièle Luce, Sophie Béjean
OBJECTIVE: To estimate the social cost of respiratory cancers attributable to occupational risk factors in France in 2010. METHODS: We estimated the number of cases of respiratory cancers attributable to each identified occupational risk factor according to the attributable fractions method. We also estimated direct (costs of hospital stays, drugs, outpatient care) and indirect costs (production losses) related to morbidity (absenteeism and presenteeism) and mortality (years of lost production)...
October 2, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28988705/implementing-head-and-neck-contouring-peer-review-without-pathway-delay-the-on-demand-approach
#17
C Fong, P Sanghera, J Good, P Nightingale, A Hartley
AIMS: Peer review of contour volume is a priority in the radiotherapy treatment quality assurance process for head and neck cancer. It is essential that incorporation of peer review activity does not introduce additional delays. An on-demand peer review process was piloted to assess the feasibility and efficiency of this approach, as compared with a historic scheduled weekly approach. MATERIALS AND METHODS: Between November 2016 and April 2017 four head and neck clinicians in one centre took part in an on-demand peer review process...
October 5, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28960576/deregulation-of-selected-micrornas-in-sinonasal-carcinoma-value-of-mir-21-as-prognostic-biomarker-in-sinonasal-squamous-cell-carcinoma
#18
Helena Kovarikova, Ivana Bubancova, Jan Laco, Katerina Sieglova, Hana Vosmikova, Milan Vosmik, Pavel Dundr, Kristyna Nemejcova, Jaroslav Michalek, Vladimir Palicka, Marcela Chmelarova
BACKGROUND: Tumors occurring in the sinonasal area are characterized by unfavorable outcome due to difficult diagnosis, treatment, and prognosis of the disease corresponding with the anatomic complexity of the area. METHODS: We used quantitative real-time polymerase chain reaction (PCR) to compare relative expression of miR-21, miR-141, and miR-200c in 70 formalin-fixed, paraffin-embedded samples of sinonasal carcinoma tissue (majority of squamous cell carcinoma [SCC] samples) with 17 control samples of sinonasal tissue...
September 28, 2017: Head & Neck
https://www.readbyqxmd.com/read/28877859/adjuvant-radiation-and-survival-following-surgical-resection-of-sinonasal-melanoma
#19
Gaurav S Ajmani, Erik Liederbach, Alex Kyrillos, Chi-Hsiung Wang, Jayant M Pinto, Mihir K Bhayani
BACKGROUND: Surgery remains the mainstay of treatment for sinonasal melanoma, but it is often difficult to obtain clear, negative margins. Therefore, patients often receive adjuvant radiation therapy (RT), however its impact on overall survival (OS) is not well understood. METHODS: Patients with surgically resected sinonasal melanoma were identified from the National Cancer Data Base (NCDB, n=696). Kaplan-Meier curves and parametric survival regression were used to analyze the impact of adjuvant RT on OS from surgery...
August 30, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28871554/the-impact-of-histologic-phenotype-in-the-treatment-of-sinonasal-cancer
#20
REVIEW
Fernando López, Valerie J Lund, Carlos Suárez, Carl H Snyderman, Nabil F Saba, K Thomas Robbins, Vincent Vander Poorten, Primož Strojan, William M Mendenhall, Alessandra Rinaldo, Alfio Ferlito
The management of sinonasal cancer is a challenge due to its low occurrence and anatomical and significant diversity of histological types. The therapeutic modality used should be tailored individually according to the histology, tumour stage, molecular profile and previous treatments. The clinical management of sinonasal cancer has improved greatly owing to developments in endoscopic surgery and precision radiotherapy. Complete surgical resection is the mainstay of sinonasal malignancies' management but multimodality therapy is associated with improved outcomes in certain histologies...
September 4, 2017: Advances in Therapy
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