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https://www.readbyqxmd.com/read/27909446/functional-toxicogenomic-profiling-expands-insight-into-modulators-of-formaldehyde-toxicity-in-yeast
#1
Matthew North, Brandon D Gaytán, Carlos Romero, Vanessa Y De La Rosa, Alex Loguinov, Martyn T Smith, Luoping Zhang, Chris D Vulpe
Formaldehyde (FA) is a commercially important chemical with numerous and diverse uses. Accordingly, occupational and environmental exposure to FA is prevalent worldwide. Various adverse effects, including nasopharyngeal, sinonasal, and lymphohematopoietic cancers, have been linked to FA exposure, prompting designation of FA as a human carcinogen by U.S. and international scientific entities. Although the mechanism(s) of FA toxicity have been well studied, additional insight is needed in regard to the genetic requirements for FA tolerance...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27896549/embryonal-rhabdomyosarcoma-in-a-patient-with-a-heterozygous-frameshift-variant-in-the-dicer1-gene-and-additional-manifestations-of-the-dicer1-syndrome
#2
Julia Fremerey, Stefan Balzer, Triantafyllia Brozou, Joerg Schaper, Arndt Borkhardt, Michaela Kuhlen
Germline mutations in the DICER1 gene are associated with an inherited cancer predisposition syndrome also known as the DICER1-syndrome, which is implicated in a broad range of tumors including pleuropulmonary blastoma, ovarian Sertoli-Leydig cell tumors, ciliary body medulloepithelioma (CBME), pituitary blastoma, embryonal rhabdomyosarcoma (eRMS), anaplastic renal sarcoma as well as ocular, sinonasal tumors ovarian sex-cord tumors, thyroid neoplasia and cystic nephroma. This study describes a novel, heterozygous frameshift DICER1 mutation in a patient, who is affected by different tumors of the DICER1-syndrome, including eRMS, CBME and suspected pleuropulmonary blastoma type I...
November 28, 2016: Familial Cancer
https://www.readbyqxmd.com/read/27857871/sinonasal-carcinomas-with-neuroendocrine-features-histopathological-differentiation-and-treatment-outcomes
#3
Liuba Soldatova, Raewyn G Campbell, Ricardo L Carrau, Daniel M Prevedello, Paul Wakely, Bradley A Otto, Leo F Ditzel Filho
Objectives Sinonasal cancers with neuroendocrine features share similar clinical, radiological, and histopathological features; however, these tumors often exhibit varying degrees of aggressive behavior presenting significant treatment challenges. The objective of this study was to report our experience with these rare malignancies and to present a review of current literature. Methods Following institutional review board approval, the records of all patients with biopsy-proven sinonasal malignancies over a 5-year period were reviewed...
December 2016: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/27846019/posttreatment-surveillance-for-sinonasal-malignancy
#4
Alan D Workman, James N Palmer, Nithin D Adappa
PURPOSE OF REVIEW: Sinonasal neoplasms have a high rate of recurrence following treatment, and clinicians utilize a variety of surveillance techniques. Generally, surveillance modality and frequency of follow-up are determined by the guidelines for head and neck cancer as a broad category. However, recent studies have demonstrated that a more tailored approach to follow-up may be necessary. RECENT FINDINGS: Endoscopy has low sensitivity in recurrence detection, especially in the asymptomatic patient...
November 14, 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27830670/sinonasal-adenocarcinoma-in-a-patient-without-exposure-to-risk-factors-case-report-and-review-of-the-literature
#5
Luciano Izzo, Sara Izzo, Pierfrancesco Di Cello, Vollono Laura, Violante Orazia, Gradini Roberto, Paolo Izzo
OBJECTIVE: Sinonasal adenocarcinoma is a tumor typically associated with exposure to occupational carcinogens. The International Agency for Research on Cancer (IARC) published several data in order to classify carcinogenic power of physical-chemical agents as far as sinonasal cancer is concerned. MATERIALS AND METHODS: We report a clinical case of sinonasal adenocarcinoma observed in an 84 years old patient, without clinical history of past exposure to carcinogens, smoke and alcohol...
July 29, 2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27814782/spanish-consensus-for-the-management-of-sinonasal-tumors
#6
Fernando López, Juan José Grau, José Antonio Medina, Isam Alobid
Sinonasal tumors are rare neoplasms with distinctive clinical, aetiological and pathological features. The diagnosis and treatment of these tumours is challenging because of their low incidence, histological diversity and production of non-specific symptoms in the early stages. They have a variable prognosis depending on their histology, origin and staging. Their location, close to neurocritical structures, which are of special relevance to surgery and postoperative treatment, makes their treatment difficult and complex, leading to high morbidity and mortality...
November 1, 2016: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/27792830/chronic-otitis-media-with-effusion-following-radiation-therapy
#7
Anya Miller, Francis Hall, Syed Ahsan
The incidence of chronic otitis media with effusion (COME) after radiotherapy for nasopharyngeal or sinonasal tumors is relatively high. It is often a difficult-to-treat problem in these patients. In this retrospective study, we sought to describe the clinical course of COME in 51 patients-33 men and 18 women, aged 39 to 90 years (mean: 58.9 ± 15)-who had been referred to the Henry Ford Health System in Detroit between 2001 and 2011 for management of a tumor that had involved either the nasopharyngeal area or the sinonasal area...
October 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27748287/spectrum-of-aids-defining-non-aids-defining-malignancies-in-north-india
#8
Ravinder Kaur Sachdeva, Aman Sharma, Surjit Singh, Subhash Varma
BACKGROUND & OBJECTIVES: There is scarcity of data on the frequency of malignancies in HIV infected individuals from India. The objective of this study was to determine the type and frequency of malignancies in HIV infected individuals attending a tertiary care hospital in north India. METHODS: The study design included retrospective analysis of data of all HIV infected individuals registered in the Immunodeficiency clinic from December 2009 to December 2011 and a prospective analysis of HIV infected individuals registered from January 2012 to April 2013...
May 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27747921/cancer-incidence-among-copper-smelting-and-nickel-refining-workers-in-finland
#9
Markku Pavela, Jukka Uitti, Eero Pukkala
BACKGROUND: Among workers employed at a nickel refinery in Harjavalta, Finland an increased risk of lung and sinus cancer has been demonstrated in two previous studies. The current study adds 16 more years of follow-up to these studies. METHODS: A total of 1,115 persons exposed to nickel and 194 non-exposed workers in the Harjavalta nickel smelter and refinery were followed up for cancer from 1967 to 2011 through the Finnish Cancer Registry. RESULTS: The total number of cancer cases in men was 251 (Standardized incidence ratio (SIR) 1...
October 17, 2016: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/27747383/prognostic-value-of-tumoral-heterogeneity-and-volumetric-parameters-as-measured-by-f18-fdg-pet-ct-in-sinonasal-cancer
#10
Bum Soo Kim, Kyoungjune Pak, Keun-Ik Yi, In Joo Kim, Hwan-Jung Roh, Kyu-Sup Cho
The objective of this study was to investigate the value of parameters assessed with F18-FDG PET/CT in predicting recurrence-free survival (RFS) and disease-specific survival (DSS) in patients with cancer of nasal cavity and paranasal sinus. Thirty-eight patients with cancer of nasal cavity (n = 14) and paranasal sinus (n = 24) who underwent PET/CT prior to curative treatment were enrolled. A volume of interest was placed on PET/CT images covering the entire tumor volume, and the maximum SUV (SUVmax), the mean SUV (SUVmean), and volumetric parameters of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were measured using thresholds of 40 % of SUVmax...
October 17, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27737700/mucosal-melanoma-of-the-head-and-neck-a-population-based-study-from-slovenia-1985-2013
#11
Gaber Plavc, Jasna But-Hadžić, Aleksandar Aničin, Boštjan Lanišnik, Vojislav Didanović, Primož Strojan
OBJECTIVES: To assess the incidence and to review experience with the treatment of mucosal melanoma of the head and neck (MMHN) in Slovenia between 1985 and 2013. METHODS: The National Cancer Registry database and clinical records with outcome data of identified patients treated during the period 1985-2013 in Slovenia were reviewed. RESULTS: In a 29-year period, 61 patients with MMHN were identified, representing 0.5 % of all head and neck malignant tumors and 42 % of all mucosal melanomas in Slovenia...
October 14, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27717204/treatment-modalities-in-sinonasal-undifferentiated-carcinoma-an-analysis-from-the-national-cancer-database
#12
Mohemmed N Khan, Neeraja Konuthula, Arjun Parasher, Eric M Genden, Brett A Miles, Satish Govindaraj, Alfred M Iloreta
BACKGROUND: Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive malignancy of unknown etiology with a poor overall prognosis. Its relative rarity has made it difficult to determine the impact of different treatment modalities on survival. METHODS: Retrospective study of cases in the National Cancer Data Base (NCDB). NCDB cases that were diagnosed as having SNUC between January 1, 2004, and December 31, 2013 were included in the analysis. Outcomes of patients treated with surgery followed adjuvant chemoradiotherapy were compared with definitive chemoradiotherapy...
October 7, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27713132/highly-elevated-serum-lactate-dehydrogenase-is-associated-with-central-nervous-system-relapse-in-patients-with-diffuse-large-b-cell-lymphoma-results-of-a-multicenter-prospective-cohort-study
#13
Seok Jin Kim, Jun Sik Hong, Myung Hee Chang, Jeong-A Kim, Jae-Yong Kwak, Jin Seok Kim, Dok Hyun Yoon, Won Sik Lee, Young Rok Do, Hye Jin Kang, Hyeon-Seok Eom, Yong Park, Jong-Ho Won, Yeung-Chul Mun, Hyo Jung Kim, Jung Hye Kwon, Jee Hyun Kong, Sung Yong Oh, Sunah Lee, Sung Hwa Bae, Deok-Hwan Yang, Hyun Jung Jun, Yang Soo Kim, Hwan Jung Yun, Soon Il Lee, Min Kyoung Kim, Eun Kyung Park, Won Seog Kim, Cheolwon Suh
Central nervous system involvement remains a challenging issue in the treatment of patients with diffuse large B-cell lymphoma. We conducted a prospective cohort study with newly diagnosed diffuse large B-cell lymphoma patients receiving rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone to identify incidence and risk factors for central nervous system involvement. Among 595 patients, 279 patients received pre-treatment central nervous system evaluation, and 14 patients had central nervous system involvement at diagnosis (2...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27703092/survival-outcomes-for-combined-modality-therapy-for-sinonasal-undifferentiated-carcinoma
#14
Phoebe Kuo, R Peter Manes, Zachary G Schwam, Benjamin L Judson
OBJECTIVE: Sinonasal undifferentiated carcinoma is a rare and aggressive malignancy of the nasal cavity and paranasal sinuses. Multi-institutional studies examining outcomes of combined modality treatment versus other treatment modalities have not been performed. The objective of our study was to present outcomes for multimodality therapy through use of the National Cancer Database. STUDY DESIGN: Retrospective cohort study. SETTING: National Cancer Database...
October 4, 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27699526/hpv-in-head-and-neck-cancer-30%C3%A2-years-of-history
#15
Stina Syrjänen, Jaana Rautava, Kari Syrjänen
The interesting history of papillomavirus (PV) research has been reviewed before. The history of human papillomavirus (HPV) in head and neck region starts in 1901 when the contagious transmission of warty lesions into the mouth via oral sex was described, although the confirmation of their viral etiology had to wait until 1907. Ullman was the first to associate the human wart virus with laryngeal warts. Parsons and Kidd described the natural history of oral PV infections in rabbits already in 1942, but these findings were corroborated in humans only recently...
2017: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27687311/mutant-kit-as-imatinib-sensitive-target-in-metastatic-sinonasal-carcinoma
#16
S M Dieter, C Heining, A Agaimy, D Huebschmann, D Bonekamp, B Hutter, K R Ehrenberg, M Fröhlich, M Schlesner, C Scholl, H-P Schlemmer, S Wolf, A Mavratzas, C S Jung, S Gröschel, C V Kalle, R Eils, B Brors, R Penzel, M Kriegsmann, D E Reuss, P Schirmacher, A Stenzinger, P A Federspil, W Weichert, H Glimm, S Fröhling
BACKGROUND: Sinonasal carcinomas (SNCs) comprise various rare tumor types that are characterized by marked histologic diversity and largely unknown molecular profiles, yet share an overall poor prognosis owing to an aggressive clinical course and frequent late-stage diagnosis. The lack of effective systemic therapies for locally advanced or metastatic SNC poses a major challenge to therapeutic decision making for individual patients. We here aimed to identify actionable genetic alterations in a patient with metastatic SNC whose tumor, despite all diagnostic efforts, could not be assigned to any known SNC category and was refractory to multimodal therapy...
September 29, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27682471/infraorbital-nerve-transposition-to-expand-the-endoscopic-transnasal-maxillectomy
#17
Giovanni Salzano, Mario Turri-Zanoni, Apostolos Karligkiotis, Jacopo Zocchi, Giovanni Dell'Aversana Orabona, Luigi Califano, Paolo Battaglia, Paolo Castelnuovo
BACKGROUND: The infraorbital nerve (ION) is a terminal branch of the maxillary nerve (V2) providing sensory innervation to the malar skin. It is sometimes necessary to sacrifice the ION and its branches to obtain adequate maxillary sinus exposure for radical resection of sinonasal tumors. Consequently, patients suffer temporary or permanent paresthesia, hypoestesthia, and neuralgia of the face. We describe an innovative technique used for preservation of the ION while removing the anterior, superior, and lateral walls of the maxillary sinus through a medial endoscopic transnasal maxillectomy...
September 28, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27681565/non-intestinal-type-sinonasal-cancers-and-exposure-to-occupational-carcinogens-a-case-control-study
#18
Matteo Bonzini, Nadia Facchinetti, Laura Zanetta, Davide Parassoni, Rossana Borchini, Paolo Battaglia, Mario Turri-Zanoni, Paolo Castelnuovo, Marco Mario Ferrario
BACKGROUND: Sinonasal cancers are rare, often fatal, tumors with a very high proportion of cases attributable to occupational exposures. The relevance of different carcinogens deeply varies among histological subtypes, with intestinal type adenocarcinomas (ITAC) characterized by a very large proportion of workers exposed to wood dust. The role of occupation in the etiology of other histotypes is less clear and more disputed, with authors questioning the possible occupational origin of non-ITAC cancers...
2016: La Medicina del Lavoro
https://www.readbyqxmd.com/read/27641784/toward-a-model-based-patient-selection-strategy-for-proton-therapy-external-validation-of-photon-derived-normal-tissue-complication-probability-models-in-a-head-and-neck-proton-therapy-cohort
#19
Pierre Blanchard, Andrew J Wong, G Brandon Gunn, Adam S Garden, Abdallah S R Mohamed, David I Rosenthal, Joseph Crutison, Richard Wu, Xiaodong Zhang, X Ronald Zhu, Radhe Mohan, Mayankkumar V Amin, C David Fuller, Steven J Frank
OBJECTIVE: To externally validate head and neck cancer (HNC) photon-derived normal tissue complication probability (NTCP) models in patients treated with proton beam therapy (PBT). METHODS: This prospective cohort consisted of HNC patients treated with PBT at a single institution. NTCP models were selected based on the availability of data for validation and evaluated by using the leave-one-out cross-validated area under the curve (AUC) for the receiver operating characteristics curve...
September 15, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27628440/the-presentation-and-outcomes-of-mucosal-melanoma-in-695-patients
#20
Neeraja Konuthula, Mohemmed N Khan, Arjun Parasher, Anthony Del Signore, Eric M Genden, Satish Govindaraj, Alfred M Iloreta
BACKGROUND: Most data on sinonasal mucosal melanoma come from small institutional studies, and therefore optimal treatment methods are not well understood. The purpose of this study was to analyze the association between treatment and survival in sinonasal mucosal melanoma. METHODS: Six hundred ninety-five patients diagnosed with sinonasal mucosal melanoma between 2004 and 2010 were identified from the National Cancer Data Base. Treatment modalities and overall survival rates were determined...
September 14, 2016: International Forum of Allergy & Rhinology
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