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https://www.readbyqxmd.com/read/29049243/rare-case-of-pulmonary-lymphomatoid-granulomatosis-in-conjunction-with-tuberculosis-a-case-report
#1
Young Woo Ha, Chul Hwan Kim, Yong Park, Jang Wook Sohn, Min Ja Kim, Young Kyung Yoon
RATIONALE: Lymphomatoid granulomatosis is a very rare Epstein-Barr virus-driven lymphoproliferative disease. This disease has high mortality owing to its low incidence in conjunction with nonspecific presentations, which contribute to delays in diagnosis. PATIENT: An 87-year-old male had a week-long history of intermittent fever and general weakness. A chest radiograph showed multifocal patchy consolidations with nodular lesions. DIAGNOSES: Open lung biopsy using video-assisted thoracic surgery resulted in a diagnosis of grade III lymphomatoid granulomatosis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049239/clinical-features-and-diagnosis-of-chronic-pulmonary-aspergillosis-in-chinese-patients
#2
Xiaomeng Hou, Hong Zhang, Lei Kou, Wei Lv, Jingjing Lu, Ji Li
Chronic pulmonary aspergillosis (CPA) has recently been recognized as a significant global health burden. In China, the diagnosis of CPA is still unfamiliar to most doctors. The aim of this study was to demonstrate the clinical manifestations and diagnoses of CPA in China.A multidisciplinary team of doctors retrospectively screened 690 records of patients diagnosed with pulmonary aspergillosis from January 2000 to December 2016 at Peking Union Medical College Hospital, Beijing, China. Of these, 69 patients were diagnosed with CPA...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049206/the-molecular-epidemiology-of-respiratory-viruses-associated-with-asthma-attacks-a-single-center-observational-study-in-japan
#3
Takeshi Saraya, Hirokazu Kimura, Daisuke Kurai, Haruyuki Ishii, Hajime Takizawa
Few reports have described the significance of viral respiratory infections (VRIs) in exacerbation of asthma in adult patients. The aim of this study was to elucidate the profiles of VRIs in adult patients with asthma along with their molecular epidemiology.A cross-sectional observational study was conducted at Kyorin University Hospital from August 2012 to May 2015. To identify respiratory pathogens in inpatients and outpatients suffering from asthma attacks, RT-PCR/sequencing/phylogenetic analysis methods were applied alongside conventional microbiological methods...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049191/significance-of-monitoring-plasma-concentration-of-voriconazole-in-a-patient-with-liver-failure-a-case-report
#4
Xiaoyan Liu, Haibin Su, Jingjing Tong, Jing Chen, Haozhen Yang, Long Xiao, Jinhua Hu, Lina Zhang
RATIONALE: Invasive pulmonary aspergillosis is associated with significant morbidity and mortality in patients with liver failure. Voriconazole (VRCZ) is recommended as a primary therapeutic agent for the treatment of invasive aspergillosis and metabolized in the liver. Now, data are still lacking on the safety and appropriate dosage of VRCZ in patients with liver failure. Here, we report a representative case of invasive pulmonary fungal infection in a patient with liver failure who was treated with low-dose VRCZ...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049181/recurrent-multiple-organ-involvement-of-disseminated-alveolar-echinococcosis-in-3-patients-case-report
#5
Leilei Xu, Sikandaer Siyiti, Xinghua Song, Hao Wen, Liwen Ding, Akbar Yunus, Zheng Tian, Chong Wang, Jiangtao Chen
RATIONALE: Alveolar echinococcosis (AE) is a rare but highly malignant form of echinococcosis caused by Echinococcus multilocularis. There have been very few reports on multiple-organ AE, especially AE in bones. Here we report 3 rare cases of disseminated multiple-organ AE from western China and its neighboring areas. PATIENT CONCERNS: Patient 1 had back and left hip pain, headache, and weakness in left lower limb, often with minor epilepsy and fluctuation of blood pressure...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29042800/postpartum-airway-responsiveness-and-exacerbation-of-asthma-during-pregnancy-a-pilot-study
#6
Zarqa Ali, Lisbeth Nilas, Charlotte Suppli Ulrik
BACKGROUND: Airway responsiveness and inflammation are associated with the clinical manifestations of asthma and the response to pharmacological therapy. OBJECTIVE: To investigate if airway responsiveness and inflammatory characteristics are related to asthma exacerbations during pregnancy. MATERIALS AND METHODS: In women with asthma who were prescribed controller medication and monitored closely during pregnancy, the risk of exacerbations was analyzed in relation to postpartum measures of fractional exhaled nitric oxide (FENO), skin prick test reactivity, static and dynamic lung volumes, diffusing capacity for carbon monoxide, bronchial responsiveness to inhaled mannitol, and inflammatory characteristics in induced sputum...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29042177/antibiotic-exposure-and-interpersonal-variance-mask-the-effect-of-ivacaftor-on-respiratory-microbiota-composition
#7
Anton Y Peleg, Jocelyn Choo, Katherine Langan, Deirdre Edgeworth, Dominic Keating, John Wilson, Geraint B Rogers, Tom Kotsimbos
BACKGROUND: G551D is a class III mutation of the cystic fibrosis transmembrane regulator (CFTR) that results in impaired chloride channel function in cystic fibrosis (CF). Ivacaftor, a CFTR-potentiating agent improves sweat chloride, weight, lung function, and pulmonary exacerbation rate in CF patients with G551D mutations, but its effect on the airway microbiome remains poorly characterised. METHODS: Twenty CF patients with at least one G551D mutation from a single centre were recruited to a 4month double-blind, placebo-controlled, crossover study of ivacaftor with 28days of active treatment...
October 14, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29042028/importance-of-the-leukotriene-b4-blt1-and-ltb4-blt2-pathways-in-asthma
#8
REVIEW
Erwin W Gelfand
For several decades, the leukotriene pathways have been implicated as playing a central role in the pathophysiology of asthma. The presence and elevation of numerous metabolites in the blood, sputum, and bronchoalveolar lavage fluid from asthmatics or experimental animals adds support to this notion. However, targeting of the leukotriene pathways has had, in general, limited success. The single exception in asthma therapy has been targeting of the cysteinyl leukotriene receptor 1, which clinically has proven effective but only in certain clinical situations...
October 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/29041961/treatment-evaluation-of-wharton-s-jelly-derived-mesenchymal-stem-cells-using-a-chronic-salpingitis-model-an-animal-experiment
#9
Zhe Li, Zhao Zhang, Xin Chen, Juan Zhou, Xiao-Min Xiao
BACKGROUND: The present study was conducted to evaluate new methods to repair the reproductive function of the oviduct, thereby allowing gametes to combine and grow in vivo under natural circumstances. METHODS: Sixty pathogen-free female New Zealand rabbits were divided into three groups: a wild-type group, an untreated control group, and a treatment group. Disposable sterile newborn sputum suction tubes were inserted into the urogenital tract to instill an Escherichia coli suspension into the uterine cavity to establish the chronic salpingitis model...
October 17, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29040453/detection-of-sputum-by-interpreting-the-time-frequency-distribution-of-respiratory-sound-signal-using-image-processing-techniques
#10
Jinglong Niu, Yan Shi, Maolin Cai, Zhixin Cao, Dandan Wang, Zhaozhi Zhang, Xiaohua Douglas Zhang
Motivation: Sputum in the trachea is hard to expectorate and detect directly for the patients who are unconscious, especially those in Intensive Care Unit (ICU). Medical staff should always check the condition of sputum in the trachea. This is time-consuming and the necessary skills are difficult to acquire. Currently, there are few automatic approaches to serve as alternatives to this manual approach. Results: We develop an automatic approach to diagnose the condition of the sputum...
October 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29040413/bilateral-cavitary-multidrug-or-extensively-drug-resistant-tuberculosis-role-of-surgery
#11
Galina Yu Marfina, Kirill B Vladimirov, Armen O Avetisian, Anna A Starshinova, Grigorii G Kudriashov, Evgenii G Sokolovich, Piotr K Yablonskii
OBJECTIVES: Cavitary disease and bilateral lesions are among the risk factors for poor outcome of pulmonary tuberculosis (TB). Our aim was to explore the value and limits of surgery in patients with advanced TB. METHODS: A retrospective study of 57 consecutive patients who underwent thoracic surgery for culture-positive bilateral cavitary pulmonary TB was performed. Forty-four (77.2%) patients were men and 13 (22.8%) patients were women; their ages were in the range of 18-61 years...
October 10, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29040263/tuberculosis-detection-and-the-challenges-of-integrated-care-in-rural-china-a-cross-sectional-standardized-patient-study
#12
Sean Sylvia, Hao Xue, Chengchao Zhou, Yaojiang Shi, Hongmei Yi, Huan Zhou, Scott Rozelle, Madhukar Pai, Jishnu Das
BACKGROUND: Despite recent reductions in prevalence, China still faces a substantial tuberculosis (TB) burden, with future progress dependent on the ability of rural providers to appropriately detect and refer TB patients for further care. This study (a) provides a baseline assessment of the ability of rural providers to correctly manage presumptive TB cases; (b) measures the gap between provider knowledge and practice and; (c) evaluates how ongoing reforms of China's health system-characterized by a movement toward "integrated care" and promotion of initial contact with grassroots providers-will affect the care of TB patients...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29038903/-nontuberculous-mycobacteria-in-sputum-recommendations-for-diagnosis-and-treatment
#13
REVIEW
J Rademacher
Pulmonary diseases caused by nontuberculous mycobacteria (NTM) have increased over the last years and decades in Germany and also worldwide. Because the disease is more frequent in patients with immunodeficiencies and chronic respiratory diseases, e.g. bronchiectasis, advanced chronic obstructive lung disease (COPD) and cystic fibrosis (CF), an infection with mycobacteria should always be considered in this patient group. The detection in sputum alone is not an indication for treatment but the correct diagnosis should be based on the appropriate clinical symptoms as well as radiological and microbiological criteria...
October 16, 2017: Der Internist
https://www.readbyqxmd.com/read/29037527/cork-study-in-cf-sustained-improvements-in-ultra-low-dose-chest-ct-scores-post-cftr-modulation-with-ivacaftor
#14
Nicola J Ronan, Gisli G Einarsson, Maria Twomey, Denver Mooney, David Mullane, Muireann NiChroinin, Grace O'Callaghan, Fergus Shanahan, Desmond M Murphy, Owen J O'Connor, Cathy A Shortt, Michael M Tunney, Joseph A Eustace, Michael M Maher, J Stuart Elborn, Barry J Plant
BACKGROUND: Ivacaftor produces significant clinical benefit in patients with cystic fibrosis (CF) with the G551D mutation. Prevalence of this mutation at Cork CF Centre is 23%. This study assessed the impact of CFTR modulation on multiple modalities of patient assessment. METHODS: Thirty three patients with the G551D mutation were assessed at baseline and prospectively three monthly for one year post initiation of ivacaftor. Change in ultra-low dose chest CT, blood inflammatory mediators, and sputum microbiome were assessed...
October 13, 2017: Chest
https://www.readbyqxmd.com/read/29037296/tuberculosis-in-recipients-of-solid-organ-transplants-during-1995-2015-in-cali-colombia
#15
J F García-Goez, G A Munera, V Rojas, R Pacheco, J A Caylá, J M Miro
SETTING: Tuberculosis (TB) in solid-organ transplants (SOTs) is an important opportunistic infection associated with mortality and graft loss. SOT recipients carry a higher risk of contracting active TB than the general population. Clinical and radiographic presentations are non-specific, and sputum smear and culture have low yields. TB patients with SOTs require standard anti-tuberculosis treatment. However, rifampicin (RMP) use is associated with a 30% rate of acute graft rejection (AGR) and a 20% rate of transplant loss...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29037293/community-based-active-case-finding-for-tuberculosis-in-rural-western-china-a-cross-sectional-study
#16
C Chen, C-G Yang, X Gao, Z-Z Lu, F-X Tang, J Cheng, Q Gao, V Cárdenas
SETTING: Current passive case finding strategies are not effective at identifying tuberculosis (TB) patients in rural China. OBJECTIVE: To evaluate a community-based, active case finding (ACF) scheme in identifying symptomatic individuals with TB. DESIGN: We conducted door-to-door household visits of all residents aged 15 years at two rural sites to screen for TB symptoms. Individuals with symptoms were enrolled and asked to provide three sputum samples...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29037292/accuracy-of-giant-african-pouched-rats-for-diagnosing-tuberculosis-comparison-with-culture-and-xpert-%C3%A2-mtb-rif
#17
C Mulder, G F Mgode, H Ellis, E Valverde, N Beyene, C Cox, S E Reid, A H Van't Hoog, T L Edwards
SETTING: Enhanced tuberculosis (TB) case finding using detection rats in Tanzania. OBJECTIVES: To assess the diagnostic accuracy of detection rats compared with culture and Xpert® MTB/RIF, and to compare enhanced case-finding algorithms using rats in smear-negative presumptive TB patients. DESIGN: A fully paired diagnostic accuracy study in which sputum of new adult presumptive TB patients in Tanzania was tested using smear microscopy, 11 detection rats, culture and Xpert...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29036990/-drug-resistance-and-dissemination-of-new-delhi-metallo-%C3%AE-lactamase-1-positive-bacteria-in-a-patient
#18
X F Zhao, M Yuan, X Chen, X F Liu, D S Yu, J Li
Objective: The aim of this work was to report the surveillance and dissemination of NDM-1 positive bacteria in a patient and ward environment. Methods: In 2010, during the therapy for a 51 years old patient, clinical and environmental samples were collected for carbapenem resistant bacterial culture, according to the clinical microbiological examination. Strains identification and antibiotic susceptibility were tested by VITEK Compact 2 system and E-test. The bla(NDM-1) was detected by PCR and analyzed by sequencing...
October 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29034041/successful-endovascular-repair-of-mycotic-aortic-pseudoaneurysm-followed-by-aortoesophageal-fistula
#19
Seiichi Yamaguchi, Hideki Ueda, Hisanori Fujita, Shigeyasu Takeuchi
Mycotic aneurysm of the aorta is a rare, but life-threatening pathology. In recent years, endovascular stent graft placement has been introduced as an effective alternative for treating infected aortic aneurysms. A 64-year-old woman with a history of paraplegia due to spinal cord injury was referred to our institute with fever and blood-tinged sputum. Computed tomography (CT) scan showed an 11-cm pseudoaneurysm arising from the proximal descending aorta, which was normal 1 month ago at the previous CT scan...
June 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29033561/specific-iga-against-pseudomonas-aeruginosa-in-severe-copd
#20
Laura Millares, Sara Martí, Carmen Ardanuy, Josefina Liñares, Salud Santos, Jordi Dorca, Marian García-Nuñez, Sara Quero, Eduard Monsó
BACKGROUND: The bronchial mucosa is protected by a specialized immune system focused on the prevention of colonization and infection by potentially pathogenic microorganisms (PPMs). Immunoglobulin A (IgA) is the principal antibody involved in this mechanism. A defective immune barrier may facilitate the recurrent presence of PPMs in COPD. PURPOSE: The aim of this study was to determine IgA-mediated bronchial specific immune responses against Pseudomonas aeruginosa in stable patients with severe disease...
2017: International Journal of Chronic Obstructive Pulmonary Disease
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