keyword
https://read.qxmd.com/read/38465724/metabolic-regulation-of-type-i-interferon-production
#21
REVIEW
Shane M O'Carroll, Fiona D R Henkel, Luke A J O'Neill
Over the past decade, there has been a surge in discoveries of how metabolic pathways regulate immune cell function in health and disease, establishing the field of immunometabolism. Specifically, pathways such as glycolysis, the tricarboxylic acid (TCA) cycle, and those involving lipid metabolism have been implicated in regulating immune cell function. Viral infections cause immunometabolic changes which lead to antiviral immunity, but little is known about how metabolic changes regulate interferon responses...
March 11, 2024: Immunological Reviews
https://read.qxmd.com/read/38464785/tanshinone-iia-ameliorates-energy-metabolism-dysfunction-of-pulmonary-fibrosis-using-13-c-metabolic-flux-analysis
#22
JOURNAL ARTICLE
Baixi Shan, Haoyan Zhou, Congying Guo, Xiaolu Liu, Mingyu Wu, Rao Zhai, Jun Chen
Evidence indicates that metabolic reprogramming characterized by the changes in cellular metabolic patterns contributes to the pathogenesis of pulmonary fibrosis (PF). It is considered as a promising therapeutic target anti-PF. The well-documented against PF properties of Tanshinone IIA (Tan IIA) have been primarily attributed to its antioxidant and anti-inflammatory potency. Emerging evidence suggests that Tan IIA may target energy metabolism pathways, including glycolysis and tricarboxylic acid (TCA) cycle...
February 2024: Journal of Pharmaceutical Analysis
https://read.qxmd.com/read/38464287/the-loss-of-opa1-accelerates-intervertebral-disc-degeneration-and-osteoarthritis-in-aged-mice
#23
Makarand Risbud, Vedavathi Madhu, Miriam Hernandez-Meadows, Ashley Coleman, Kimheak Sao, Kameron Inguito, Owen Haslam, Paige Boneski, Hiromi Sesaki, John Collins
NP cells of the intervertebral disc and articular chondrocytes reside in avascular and hypoxic tissue niches. As a consequence of these environmental constraints the cells are primarily glycolytic in nature and were long thought to have a minimal reliance on mitochondrial function. Recent studies have challenged this long-held view and highlighted the increasingly important role of mitochondria in the physiology of these tissues. However, the foundational understanding of mechanisms governing mitochondrial dynamics and function in these tissues is lacking...
February 20, 2024: Research Square
https://read.qxmd.com/read/38464098/metabolic-phenotyping-of-healthy-and-diseased-human-rpe-cells
#24
Saira Rizwan, Beverly Toothman, Bo Li, Abbi J Engel, Rayne R Lim, Jinyu Lu, Jennifer R Chao, Jianhai Du
PURPOSE: Metabolic defects in retinal pigment epithelium (RPE) are underlying many retinal degenerative diseases. This study aims to identify the nutrient requirements of healthy and diseased human RPE cells. METHODS: We profiled the utilization of 183 nutrients in human RPE cells: 1) differentiated and dedifferentiated fetal RPE (fRPE), 2) induced pluripotent stem cell derived-RPE (iPSC RPE), 3) Sorsby fundus dystrophy (SFD) patient-derived iPSC RPE and its CRISPR-corrected isogenic SFD (cSFD) iPSC RPE, and 5) ARPE-19 cell lines cultured under different conditions...
March 1, 2024: bioRxiv
https://read.qxmd.com/read/38463329/strategies-to-enhance-l-isoleucine-synthesis-by-modifying-the-threonine-metabolism-pathway-in-escherichia-coli
#25
JOURNAL ARTICLE
HaoJie Zhang, Tong Ye, Liu Fengmin, Xiangjun Zhang, Jipeng Wang, Xiaobo Wei, Yun Ping Neo, Huiyan Liu, Haitian Fang
l-threonine as an important precursor substance of l-isoleucine and improving its accumulation in Escherichia coli became an important idea to construct a chassis strain with high l-isoleucine production. Meanwhile, the effect of l-threonine metabolic pathway disruption in E. coli for the improved production of l-isoleucine remains unrevealed. In the present study, a mutant strain of E. coli was engineered by inactivating specific metabolic pathways (e.g., Δ tdh , Δ ltaE , and Δ yiaY ) that were associated with l-threonine metabolism but unrelated to l-isoleucine synthesis...
March 5, 2024: ACS Omega
https://read.qxmd.com/read/38462228/plasma-membrane-calcium-atpase-powered-by-glycolysis-is-the-main-mechanism-for-calcium-clearance-in-the-hippocampal-pyramidal-neuron
#26
JOURNAL ARTICLE
Vitor S Alves, Fernando A Oliveira
AIMS: This study sought to elucidate the primary ATP-dependent mechanisms involved in clearing cytosolic Ca2+ in neurons and determine the predominant ATP-generating pathway-glycolysis or tricarboxylic acid cycle/oxidative phosphorylation (TCA/OxPhos)-associated with these mechanisms in hippocampal pyramidal neurons. MAIN METHODS: Our investigation involved evaluating basal Ca2+ levels and analyzing the kinetic characteristics of evoked neuronal Ca2+ transients after selectively combined the inhibition/blockade of key ATP-dependent mechanisms with the suppression of either TCA/OxPhos or glycolytic ATP sources...
March 8, 2024: Life Sciences
https://read.qxmd.com/read/38460078/diosmetin-ameliorates-hfd-induced-cognitive-impairments-via-inhibiting-metabolic-disorders-mitochondrial-dysfunction-and-neuroinflammation-in-male-sd-rats
#27
JOURNAL ARTICLE
Yiyuan Zhang, Chunyun Luo, Puxin Huang, Yahong Cheng, Yufang Ma, Jiefang Gao, Hong Ding
Currently, accumulating evidence has indicated that overnutrition-associated obesity may result in not only metabolic dysregulations, but also cognitive impairments. This study aimed to investigate the protective effects of Diosmetin, a bioflavonoid compound with multiple biological functions, on cognitive deficits induced by a high fat diet (HFD) and the potential mechanisms. In the present study, oral administration of Diosmetin (25, 50 and 100 mg/kg) for 12 weeks significantly reduced the body weight, restored glucose tolerance and normalized lipid profiles in the serum and liver in HFD-induced obese rats...
March 9, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38457521/rapid-dissemination-of-host-metabolism-manipulating-genes-via-integrative-and-conjugative-elements
#28
JOURNAL ARTICLE
Elena Colombi, Frederic Bertels, Guilhem Doulcier, Ellen McConnell, Tatyana Pichugina, Kee Hoon Sohn, Christina Straub, Honour C McCann, Paul B Rainey
Integrative and conjugative elements (ICEs) are self-transmissible mobile elements that transfer functional genetic units across broad phylogenetic distances. Accessory genes shuttled by ICEs can make significant contributions to bacterial fitness. Most ICEs characterized to date encode readily observable phenotypes contributing to symbiosis, pathogenicity, and antimicrobial resistance, yet the majority of ICEs carry genes of unknown function. Recent observations of rapid acquisition of ICEs in a pandemic lineage of Pseudomonas syringae pv...
March 12, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38457520/the-metabolic-domestication-syndrome-of-budding-yeast
#29
JOURNAL ARTICLE
Roland Tengölics, Balázs Szappanos, Michael Mülleder, Dorottya Kalapis, Gábor Grézal, Csilla Sajben, Federica Agostini, João Benhur Mokochinski, Balázs Bálint, László G Nagy, Markus Ralser, Balázs Papp
Cellular metabolism evolves through changes in the structure and quantitative states of metabolic networks. Here, we explore the evolutionary dynamics of metabolic states by focusing on the collection of metabolite levels, the metabolome, which captures key aspects of cellular physiology. Using a phylogenetic framework, we profiled metabolites in 27 populations of nine budding yeast species, providing a graduated view of metabolic variation across multiple evolutionary time scales. Metabolite levels evolve more rapidly and independently of changes in the metabolic network's structure, providing complementary information to enzyme repertoire...
March 12, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38455734/acetylome-analyses-provide-novel-insights-into-the-effects-of-chronic-intermittent-hypoxia-on-hippocampus-dependent-cognitive-impairment
#30
JOURNAL ARTICLE
Fan Liu, Weiheng Yan, Chen Chen, Yubing Zeng, Yaru Kong, Xuejia He, Pei Pei, Shan Wang, Ting Zhang
INTRODUCTION: Chronic intermittent hypoxia (CIH) can negatively affect hippocampal function through various molecular mechanisms. Protein acetylation, a frequently occurring modification, plays crucial roles in synaptic plasticity and cognitive processes. However, the global protein acetylation induced by CIH in the hippocampus and its specific effects on hippocampal function and behavior remain poorly understood. METHODS: To address this gap, we conducted a study using liquid chromatography-tandem mass spectrometry to analyze the lysine acetylome and proteome of the hippocampus in healthy adult mice exposed to intermittent hypoxia for 4 weeks (as a CIH model) compared to normoxic mice (as a control)...
2024: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/38455602/%C3%AE-caryophyllene-attenuates-oxidative-stress-and-hepatocellular-mitochondrial-dysfunction-in-type-2-diabetic-rats-induced-with-high-fat-and-fructose-diets
#31
JOURNAL ARTICLE
Vadivel Mani, Ipsita Dash, Sangeeta Chandrashekar, Muninathan Natarajan
OBJECTIVE: Hyperglycemia, hyperlipidemia, and systemic resistance to insulin are typical manifestations of type 2 diabetes mellitus. One of the main pathophysiological alterations in insulin-sensitive organs is mitochondrial malfunction associated with oxidative stress and diminished fuel utilization. β-Caryophyllene (BCP) has qualities that are anti-inflammatory, anti-tumor, antioxidant, hypolipidemic, and hypoglycemic. In this work, rats suffering from type 2 diabetes were given a diet high in fat and sugar with the aim of examining the ameliorative effects of BCP on oxidative stress-mediated hepatic mitochondrial dysfunction...
2024: International Journal of Health Sciences
https://read.qxmd.com/read/38455195/regulatory-effects-of-mangiferin-on-lps-induced-inflammatory-responses-and-intestinal-flora-imbalance-during-sepsis
#32
JOURNAL ARTICLE
Bo-Tao Chang, Yang Wang, Wen-Lian Tu, Zhi-Qing Zhang, Yan-Fang Pu, Li Xie, Fang Yuan, Ying Gao, Ning Xu, Qi Yao
Studies suggest that mangiferin (MAF) has good therapeutic effects on chronic bronchitis and hepatitis. Also, it is one of the antiviral ingredients in Anemarrhena asphodeloides Bunge. However, its effect on the LPS-induced inflammation and intestinal flora during sepsis remains unclear yet. In the present study, LPS-stimulated inflammation RAW264.7 cells and LPS-induced sepsis mice were used to evaluate the efficacy of MAF in vitro and in vivo. 16S rDNA sequencing was performed to analyze the characteristics of intestinal flora of the sepsis mice...
March 2024: Food Science & Nutrition
https://read.qxmd.com/read/38453076/living-in-a-dynamic-environment-the-effects-of-multi-ways-temperature-variation-on-embryo-and-newborn-juveniles-of-a-shallow-water-octopus-amphioctopus-fangsiao
#33
JOURNAL ARTICLE
Jian Zheng, Shuwen Li, Xiaodong Zheng
Shallow waters are characterized by fluctuating environmental conditions, modulating marine life cycles and biological phenomena. Multiple variations in water temperature could affect eggs and embryos during spawning events of many marine invertebrate species, yet most of the findings on embryonic development in invertebrates come from experiments based on the constant temperature. In this study, to examine the effects of temperature variation on octopus embryos, Amphioctopus fangsiao, a common shallow-water octopus along the coast of China, was exposed to the constant temperature (18 °C, in situ temperature of the seawater in Lianyungang), ramping temperatures (from 18 to 24 °C), diel oscillating temperatures (18 °C and 20 °C for 12 h each day), and acute increasing temperatures (the temperature increased sharply from 18 °C to 24 °C at embryonic development stage XIX) for 47 days (from embryogenesis to settlement)...
March 5, 2024: Science of the Total Environment
https://read.qxmd.com/read/38452242/metabolic-regulation-of-neutrophil-functions-in-homeostasis-and-diseases
#34
JOURNAL ARTICLE
Pier-Olivier Leblanc, Sylvain G Bourgoin, Patrice E Poubelle, Philippe A Tessier, Martin Pelletier
Neutrophils are the most abundant leukocytes in humans and play a role in the innate immune response by being the first cells attracted to the site of infection. While early studies presented neutrophils as almost exclusively glycolytic cells, recent advances show that these cells use several metabolic pathways other than glycolysis, such as the pentose phosphate pathway, oxidative phosphorylation, fatty acid oxidation, and glutaminolysis, which they modulate to perform their functions. Metabolism shifts from fatty acid oxidation-mediated mitochondrial respiration in immature neutrophils to glycolysis in mature neutrophils...
March 7, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38451006/stable-isotope-tracer-technique-and-network-pharmacology-to-reveal-antidepressant-targets-and-active-components-of-xiaoyao-san
#35
JOURNAL ARTICLE
Junsheng Tian, Xianxian Wang, Wenze Wu, Yunhao Zhao, Ting Ling-Hu, Xuemei Qin
In recent years, the research of mitochondrial dysfunction in depression has drawn the focus of researchers. Our research group previously found that Xiaoyao San (XYS) has improved the mitochondrial structure and the blocked tricarboxylic acid cycle (TCA cycle) in the hippocampal tissue of chronic unpredictable mild stress (CUMS) rats. However, the specific targets and active components of XYS remain unclear, and the potential to improve hippocampal mitochondrial TCA cycle disorder was also unexplored...
March 7, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38447582/hepatic-malonyl-coa-synthesis-restrains-gluconeogenesis-by-suppressing-fat-oxidation-pyruvate-carboxylation-and-amino-acid-availability
#36
JOURNAL ARTICLE
Stanislaw Deja, Justin A Fletcher, Chai-Wan Kim, Blanka Kucejova, Xiaorong Fu, Monika Mizerska, Morgan Villegas, Natalia Pudelko-Malik, Nicholas Browder, Melissa Inigo-Vollmer, Cameron J Menezes, Prashant Mishra, Eric D Berglund, Jeffrey D Browning, John P Thyfault, Jamey D Young, Jay D Horton, Shawn C Burgess
Acetyl-CoA carboxylase (ACC) promotes prandial liver metabolism by producing malonyl-CoA, a substrate for de novo lipogenesis and an inhibitor of CPT-1-mediated fat oxidation. We report that inhibition of ACC also produces unexpected secondary effects on metabolism. Liver-specific double ACC1/2 knockout (LDKO) or pharmacologic inhibition of ACC increased anaplerosis, tricarboxylic acid (TCA) cycle intermediates, and gluconeogenesis by activating hepatic CPT-1 and pyruvate carboxylase flux in the fed state. Fasting should have marginalized the role of ACC, but LDKO mice maintained elevated TCA cycle intermediates and preserved glycemia during fasting...
March 1, 2024: Cell Metabolism
https://read.qxmd.com/read/38447055/distribution-and-functional-analysis-of-isocitrate-dehydrogenases-across-kinetoplastids
#37
JOURNAL ARTICLE
Ľubomíra Chmelová, Kristína Záhonová, Amanda T S Albanaz, Liudmyla Hrebenyk, Anton Horváth, Vyacheslav Yurchenko, Ingrid Škodová-Sveráková
Isocitrate dehydrogenase (IDH) is an enzyme converting isocitrate to α-ketoglutarate in the canonical tricarboxylic acid (TCA) cycle. There are three different types of IDH documented in eukaryotes. Our study points out the complex evolutionary history of IDHs across kinetoplastids, where the common ancestor of Trypanosomatidae and Bodonidae was equipped with two isoforms of the IDH enzyme: the NADP+-dependent IDH1 with possibly dual localization in the cytosol and mitochondrion and NADP+-dependent mitochondrial IDH2...
March 6, 2024: Genome Biology and Evolution
https://read.qxmd.com/read/38446901/sex-differences-in-kidney-metabolism-may-reflect-sex-dependent-outcomes-in-human-diabetic-kidney-disease
#38
JOURNAL ARTICLE
Sergi Clotet-Freixas, Olga Zaslaver, Max Kotlyar, Chiara Pastrello, Andrew T Quaile, Caitriona M McEvoy, Aninda D Saha, Sofia Farkona, Alex Boshart, Katarina Zorcic, Slaghaniya Neupane, Kieran Manion, Maya Allen, Michael Chan, Xuqi Chen, Arthur P Arnold, Peggy Sekula, Inga Steinbrenner, Anna Köttgen, Allison B Dart, Brandy Wicklow, Jon M McGavock, Tom D Blydt-Hansen, Clara Barrios, Marta Riera, María José Soler, Amandine Isenbrandt, Jérôme Lamontagne-Proulx, Solène Pradeloux, Katherine Coulombe, Denis Soulet, Shravanthi Rajasekar, Boyang Zhang, Rohan John, Aman Mehrotra, Adam Gehring, Maija Puhka, Igor Jurisica, Minna Woo, James W Scholey, Hannes Röst, Ana Konvalinka
Diabetic kidney disease (DKD) is the main cause of chronic kidney disease (CKD) and progresses faster in males than in females. We identify sex-based differences in kidney metabolism and in the blood metabolome of male and female individuals with diabetes. Primary human proximal tubular epithelial cells (PTECs) from healthy males displayed increased mitochondrial respiration, oxidative stress, apoptosis, and greater injury when exposed to high glucose compared with PTECs from healthy females. Male human PTECs showed increased glucose and glutamine fluxes to the TCA cycle, whereas female human PTECs showed increased pyruvate content...
March 6, 2024: Science Translational Medicine
https://read.qxmd.com/read/38442606/blue-light-irradiation-induced-partial-nitrification
#39
JOURNAL ARTICLE
Ru Zheng, Yiming Feng, Lingrui Kong, Xiaogang Wu, Jianhang Zhou, Liguo Zhang, Sitong Liu
The role of ray radiation from the sunlight acting on organisms has long-term been investigated. However, how the light with different wavelengths affects nitrification and the involved nitrifiers are still elusive. Here, we found more than 60 % of differentially expressed genes (DEGs) in nitrifiers were observed under irradiation of blue light with wavelengths of 440-480 nm, which were 13.4 % and 20.3 % under red light and white light irradiation respectively. Blue light was more helpful to achieve partial nitrification rather than white light or red light, where ammonium oxidization by ammonia-oxidizing archaea (AOA) with the increased relative abundance from 8...
February 27, 2024: Water Research
https://read.qxmd.com/read/38441406/programming-a-ferroptosis-to-apoptosis-transition-landscape-revealed-ferroptosis-biomarkers-and-repressors-for-cancer-therapy
#40
JOURNAL ARTICLE
Yaron Vinik, Avi Maimon, Vinay Dubey, Harsha Raj, Ifat Abramovitch, Sergey Malitsky, Maxim Itkin, Avi Ma'ayan, Frank Westermann, Eyal Gottlieb, Eytan Ruppin, Sima Lev
Ferroptosis and apoptosis are key cell-death pathways implicated in several human diseases including cancer. Ferroptosis is driven by iron-dependent lipid peroxidation and currently has no characteristic biomarkers or gene signatures. Here a continuous phenotypic gradient between ferroptosis and apoptosis coupled to transcriptomic and metabolomic landscapes is established. The gradual ferroptosis-to-apoptosis transcriptomic landscape is used to generate a unique, unbiased transcriptomic predictor, the Gradient Gene Set (GGS), which classified ferroptosis and apoptosis with high accuracy...
March 5, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
keyword
keyword
80425
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.