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https://www.readbyqxmd.com/read/29901571/indoleamine-2-3-dioxygenase-in-non-small-cell-lung-cancer-a-targetable-mechanism-of-immune-resistance-frequently-coexpressed-with-pd-l1
#1
Ashley Volaric, Ryan Gentzler, Richard Hall, James H Mehaffey, Edward B Stelow, Timothy N Bullock, Linda W Martin, Anne M Mills
The immune regulatory enzyme indoleamine-2,3-dioxygenase (IDO-1) suppresses T cell responses and may reduce efficacy of therapies targeting immune checkpoints such as programmed death receptor-1/programmed death ligand-1 (PD-1/PD-L1). Early phase clinical trials combining IDO-1 and PD-1/PD-L1 inhibitors have shown some promise in non-small cell lung cancers (NSCLCs). However, the coexpression of IDO-1 and PD-L1 has not been thoroughly investigated, and the potential for IDO-1 immunohistochemical expression as a therapeutic biomarker is unknown...
June 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29890885/a-fresh-look-at-radial-shaft-fracture-fixation-the-lateral-approach-to-the-radius
#2
Muhammad Haseeb, Khalid Muzafar, Abdul Ghani, Khurshid A Bhat, M Farooq Butt
INTRODUCTION: Open reduction and internal fixation using plates is the gold standard for the treatment of displaced forearm bone fractures in adults. The ulna being subcutaneous throughout has a constant approach. However, the radius is approached from either the dorsal or the volar side. Both the dorsal and the volar approaches to the radial shaft involve meticulous dissection and preservation of important neurovascular structures. The posterior interosseus nerve is at risk in the dorsal approach and the radial artery and its branches in the volar approach...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29881179/percutaneous-pinning-versus-volar-locking-plate-fixation-for-dorsally-displaced-distal-radius-fractures-reoperation-rates-over-an-eight-year-period
#3
Quintin Liao, Nathan C Skipper, Michael J Brown, Paul J Jenkins
Purpose: To compare reoperation rates between closed reduction with percutaneous pinning (CRPP) and internal fixation with a volar locking plate (VLP) for the treatment of distal radius fractures. Methods: A retrospective review of all patients with dorsally displaced distal radius fractures presenting to a hospital over an eight-year period. Results: 1364 procedures were reviewed after applying the exclusion criteria; 663 underwent CRPP and 701 underwent VLP...
June 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29876494/acute-flexor-tendon-injury-following-midshaft-radius-and-ulna-fractures-in-a-paediatric-patient
#4
James Williams, Rupert Wharton, Peter Peev, Maxim Horwitz
Delayed rupture of the extensor and flexor tendons are recognised complications of distal radius fractures. However, acute flexor tendon rupture in the context of forearm fractures is rare. A twelve-year-old female sustained midshaft fractures of the radius and ulna. Intra-operatively the flexor pollicis longus (FPL) was found to be stripped from its musculotendinous junction at the level of the fracture fragment. The ruptured tendon was repaired using a modified Krackow technique at the time of fracture fixation...
June 2018: Trauma Case Reports
https://www.readbyqxmd.com/read/29871493/accuracy-and-reliability-of-radiographic-estimation-of-volar-lip-fragment-size-in-pip-dorsal-fracture-dislocations
#5
Daniel S Donovan, Jeremy D Podolnick, Wayne Reizner, O Alton Barron, Louis W Catalano, Steven Z Glickel
BACKGROUND: A cadaveric study was performed to evaluate the accuracy and reliability of radiographic estimation of the volar lip fragment size in proximal interphalangeal joint fracture-dislocations. METHODS: Middle phalangeal base volar lip fractures of varying size and morphology were simulated in 18 digits. Radiographs and digital photographs of the middle phalangeal joint surface were obtained pre- and postinjury. Ten orthopedic surgeons of varying levels of training estimated the fracture size based on radiographs...
June 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29870507/procurement-of-extended-vascularized-skin-flaps-from-the-donor-enables-hand-transplantation-in-severe-upper-extremity-burns-an-anatomical-study
#6
Edoardo Dalla Pozza, Bahar Bassiri Gharb, Francis A Papay, Richard L Drake, Andrew Steckler, Antonio Rampazzo
BACKGROUND: Hand transplantation in patients with severe upper extremity burns can be associated with an increased risk of exposure of vessels, tendons and nerves because of extensive skin and soft tissue deficit. This study evaluated how to reliably transfer additional extended skin flaps with a standard hand allograft. METHODS: Twenty-five upper extremities were used. Sixteen were injected with latex to map the perforating branches of the brachial (BA), superior ulnar collateral (SUCA), radial (RA), ulnar (UA) and posterior interosseous (PIA) arteries...
May 19, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29869793/diffuse-reflectance-spectroscopy-as-a-reliable-means-of-comparing-ultraviolet-radiation-induced-erythema-in-extreme-skin-colours
#7
Damilola Fajuyigbe, A Coleman, Robert P E Sarkany, Antony R Young, A W Schmalwieser
Erythema is widely considered an indicator of skin cancer susceptibility but assessments is challenging in black skin because melanin can mask erythema under traditional visual and advanced objective Commission Internationale de l'Eclairage (CIE) L*a*b* assessments. Using spectral measurements (400-700nm) from a spectrophotometer, an algorithm was developed to measure erythema in white Caucasians (n=9) and black West Africans (n=11) 19 - 24h post-solar simulated radiation (SSR) exposures to the volar forearm...
June 5, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29869724/treatment-of-the-distal-radius-fractures-with-percutaneous-pinning-evolution-to-the-hk2-system
#8
Emmanuel J Camus, Luc Van Overstraeten
Displaced fractures of the distal radius often require reduction and fixation to improve outcome in active patients. The volar locking plate gained ground over pinning, which was the first surgical solution described. But pinning methods have since evolved with fewer complications. The authors present a clinical study of distal radius fracture fixation using the HK2 technique, where subchondral pins are connected to intra-focal pins. The results are satisfactory with a lower complication rate compared to other pinning methods...
June 5, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29867277/volar-dislocation-of-the-fifth-carpometacarpal-joint
#9
David J Milligan, Neville W Thompson, Diarmaid O'Longain
No abstract text is available yet for this article.
May 2018: Ulster Medical Journal
https://www.readbyqxmd.com/read/29866626/frailty-and-body-mass-index-are-associated-with-biophysical-properties-of-the-skin-in-community-dwelling-older-adults
#10
Shinji Iizaka
AIM OF THE STUDY: This study aimed to investigate the association of frailty and body mass index (BMI) with biophysical properties of the skin in community-dwelling older people. MATERIALS AND METHODS: A cross-sectional study was conducted in a suburban Japanese city. Older adults aged ≥65 years and participating in a health checkup program were recruited (n = 128). Stratum corneum hydration, clinical manifestations of dry skin, skin elasticity and condition of the dermis (as measured by ultrasonography) were evaluated on the volar forearm...
May 23, 2018: Journal of Tissue Viability
https://www.readbyqxmd.com/read/29865010/evaluating-the-ability-of-non-rectangular-electrical-pulse-forms-to-preferentially-activate-nociceptive-fibers-by-comparing-perception-thresholds
#11
R Hugosdottir, C D Mørch, O K Andersen, T Helgason, L Arendt-Nielsen
Aims Selective activation of nociceptive fibers is difficult using electrical stimulation as the activation threshold is higher than for non-nociceptive fibers. It remains unclear to what extent accommodation of non-nociceptive fibers during slowly rising electrical pulses can be utilized to reverse this activation order. The aim of this study was to evaluate the ability of different pulse forms to activate nociceptive fibers with minimal co-activation of non-nociceptive fibers by comparing subjective perception thresholds (PT)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29865008/assessing-offset-analgesia-through-electrical-stimulations-in-healthy-volunteers
#12
D Ligato, K K Petersen, C D Mørch, L Arendt-Nielsen
Background and aims Offset Analgesia (OA) is a disproportionally large decrease of pain perception evoked by a slight decrease of a painful cutaneous heat stimulus, resulting in a lower pain perception compared to a simple constant stimulus at the same temperature. This study aimed to investigate the possibility of evoking the same disproportional analgesic effect by applying electrical stimuli. Methods 24 subjects underwent two control-trials of 30 s constant intensity by applying either heat stimulation at 48 °C or an electrical stimulation at 150% of the individual electrical Pain Detection (ePD) on the volar forearm...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29864999/the-effect-of-uvb-induced-skin-inflammation-on-histaminergic-and-non-histaminergic-evoked-itch-and-pain
#13
S Lo Vecchio, H H Andersen, J Elberling, L Arendt-Nielsen
Aims Itch often occurs in cutaneous conditions characterized by some degree of inflammation, e.g. atopic dermatitis, psoriasis or urticaria. It is unclear to which extent cutaneous inflammation causes sensitization of pruriceptive primary afferent C-fibers. The aim of this study was to explore if inflammation induced by UVB (B-ultraviolet rays) modify neurogenic inflammation and itch associated with experimental itch provocations. Methods Twenty healthy volunteers (10F/10M, 26.2 ± 1.6 years) were included...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29864993/tempo-spatial-discrimination-to-non-noxious-stimuli-is-better-than-for-noxious-stimuli
#14
Ken Steffen Frahm, Carsten Dahl Mørch, Ole Kæseler Andersen
Aims The exteroceptive sensory system is responsible for sensing external stimuli in relation to time and space. The aim of the study was to investigate the tempo-spatial properties of the exteroceptive system using laser heat and mechanical touch stimulation. Methods 13 healthy subjects were stimulated in the volar forearm. Each subject was stimulated using two paradigms, a continuous stimulation along a continuous line on the skin, and a simultaneous 2-point stimulation. The line stimulations were delivered in both a distal and proximal direction with lengths of 25, 50, 75, and 100 mm...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29864967/topical-allyl-isothiocyanate-mustard-oil-as-a-trpa1-dependent-human-surrogate-model-of-pain-hyperalgesia-and-neurogenic-inflammation-a-dose-response-study
#15
H H Andersen, S Lo Vecchio, P Gazerani, L Arendt-Nielsen
Aims Transient receptor potential ion channel A1 (TRPA1) has been shown to play a pathoetiological role in several painful and inflammatory conditions and therefore several new drug candidates, targeting TRPA1 are currently being developed [1]. While the natural TRPA1-agonist allyl-isothiocyanate (AITC, known as "mustard oil") is an exceedingly common animal pain model, it has only been sparsely investigated as a potential human surrogate model of pain and neurogenic inflammation. This study aimed to evaluate dose-response features of AITC as a sensitizing, algogenic irritant in human skin...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29845802/-surgical-techniques-and-effectiveness-of-volar-locking-plates-for-senile-delayed-distal-radius-fractures
#16
Mingjian Xu, Fuzhou Xiang, Chunxiao Li, Sulaiti Xiaohereti, Jiagen Sheng
Objective: To investigate the surgical technique and effectiveness of volar locking plates for senile delayed distal radius fractures. Methods: Between October 2014 and September 2015, 25 cases of delayed distal radius fractures were treated by volar locking plates. There were 3 males and 22 females with an average age of 73 years (range, 65-87 years). Injury was caused by tumble in 19 cases and by traffic accident in 6 cases. All the cases had closed fracture. According to the AO classification, 10 cases were rated as type A2, 7 cases as type A3, 3 cases as type B3, and 5 cases as type C1...
July 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29845047/the-radiographic-quality-of-distal-radius-fracture-reduction-using-sedation-versus-hematoma-block
#17
Lior Koren, Eyal Ginesin, Shahem Elias, Ronit Wollstein, Shlomo Israelit
Introduction: Distal radius fractures (DRFs) are treated in the emergency department (ED) with a closed reduction in order to decrease neurovascular and soft tissue injury and as a first definitive step in conservative treatment. The type of anesthesia used may affect the ability to reduce the fracture and remains controversial. Objective: The purpose of this study was to compare the quality of radiographic reduction achieved in the ED of DRF reduced using sedation anesthesia to those reduced with hematoma block anesthesia...
May 2018: Plastic Surgery
https://www.readbyqxmd.com/read/29807189/full-title-biomechanical-comparison-between-stainless-steel-titanium-and-carbon-fiber-reinforced-polyetheretherketone-volar-locking-plates-for-distal-radius-fractures
#18
Raffaele Mugnai, Luigi Tarallo, Francesco Capra, Fabio Catani
INTRODUCTION: As the popularity of volar locked plate fixation for distal radius fractures has increased, so have the number and variety of implants, including variations in plate design, the size and angle of the screws, the locking screw mechanism, and the material of the plates. HYPOTHESIS: carbon-fiber reinforced polyetheretherketone (CFR-PEEK) plate features similar biomechanical properties to metallic plates, representing, therefore, an optimal alternative for the treatment of distal radius fractures...
May 25, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29807188/double-tiered-subchondral-support-fixation-with-optimal-distal-dorsal-cortical-distance-using-a-variable-angle-volar-locking-plate-system-for-distal-radius-fracture-in-the-elderly
#19
Sang Ki Lee, Young Sub Chun, Hyun Min Shin, Soo Min Kim, Won Sik Choy
BACKGROUND: Double-tiered subchondral support (DSS) procedures with optimal distal dorsal cortical distance (DDD) have been reported to be effective in treating distal radius fractures, but there have been no studies of osteoporotic distal radius fractures in elderly patients. In this study, we demonstrated the efficacy of the DSS procedure with optimal DDD using a variable-angle volar locking plate system for the treatment of osteoporotic distal radius fractures in elderly patients. METHODS: 122 patients (mean age, 73...
May 25, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29806282/-effectiveness-comparison-between-minimally-invasive-surgery-and-traditional-open-reduction-internal-fixation-in-treatment-of-unstable-distal-radial-fractures
#20
Zeli Zhong, Chao Wu, Xu Lin, Haigang Hu
Objective: To compare the effectiveness of minimally invasive percutaneous internal fixation and traditional open reduction via Henry approach and internal fixation in the treatment of unstable distal radial fractures. Methods: Fifty-six patients with unstable distal radial fractures that met the selection criteria between October 2013 and December 2014 were randomly divided into minimally invasive group (26 cases) and traditional group (30 cases). They were treated with oblique T-shaped locking plate internal fixation via minimally invasive percutaneous approach or traditional Henry approach...
March 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
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