Yaping Yan, Ailing Luo, Shanshan Liu, Mansi Cai, Xiaodan Liu, Xiaohong Zhang, Siyi Zhang, Yu Liu, Jiamin Zeng, Xinke Xu, Na Zhang, Zhuorong Zhang, Yingyi Xu, Jing He, Xiaoping Liu
Mitochondrial fission promotes glioma progression. The function and regulation mechanisms of lncRNAs in glioma mitochondrial fission are unclear. The expression of LINC00475 and its correlation with clinical parameters in glioma were analyzed using bioinformatics. Then, in vitro and in vivo assays were performed to explore the function of spliced variant LINC00475 (LINC00475-S) in gliomas. To explore the mechanisms, RNA-seq, MeRIP, RIP, pulldown-IP, dCas9-ALKBH5 editing system, LC/MS, and Western blotting were utilized...
2024: Research: a science partner journal