keyword
https://read.qxmd.com/read/38455364/assessing-the-causal-relationship-between-genetically-determined-inflammatory-cytokines-and-parkinson-s-disease-risk-a-bidirectional-two-sample-mendelian-randomization-study
#21
JOURNAL ARTICLE
Hua Xue, Qian Luo, Jiajia Chen, Wenhui Fan
BACKGROUND: Observational studies have suggested an association between inflammatory cytokines and Parkinson's disease (PD). This Mendelian randomization (MR) was conducted to further assess the causal correlations between inflammatory cytokines and PD. METHODS: Genetic instruments associated with inflammatory cytokines were extracted from a large summary genome-wide association studies (GWAS) involving 8,293 European participants. Summary-level statistics for PD were obtained from a large-sample GWAS containing 17 studies that involved European participants...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38451373/discovery-of-circulating-blood-biomarkers-in-patients-with-and-without-modic-changes-of-the-lumbar-spine-a-preliminary-analysis
#22
JOURNAL ARTICLE
Khaled Aboushaala, Ana V Chee, Sheila J Toro, Rajko Vucicevic, Catherine Yuh, Jake Dourdourekas, Ishani K Patel, Alejandro Espinoza-Orias, Chundo Oh, Lena Al-Harthi, Jaro Karppinen, Edward J Goldberg, Frank M Phillips, Matthew Colman, Frances M K Williams, Jeffrey A Borgia, Stefan Green, Christopher Forsyth, Howard S An, Dino Samartzis
PURPOSE: The following study aimed to determine the existence of blood biomarkers in symptomatic patients with or without lumbar Modic changes (MC). METHODS: A cross-sectional sub-analyses of a prospective cohort was performed. Fasting blood samples were collected from patients with and without lumbar MC who had undergone spinal fusion or microdiscectomy. An 80-plex panel and CCL5/RANTES were used to assess preoperative plasma cytokine concentrations. Patient demographics and imaging phenotypes were also assessed...
March 7, 2024: European Spine Journal
https://read.qxmd.com/read/38447611/potential-role-of-lymphocyte-cd44-in-determining-treatment-selection-between-stereotactic-body-radiotherapy-and-surgery-for-early-stage-non-small-cell-lung-cancer
#23
JOURNAL ARTICLE
Weiwei Yan, Ziyuan Ren, Xi Chen, Ran Zhang, Juncai Lv, Vivek Verma, Meng Wu, Dawei Chen, Jinming Yu
BACKGROUND: Stereotactic body radiotherapy (SBRT) versus surgery for operable early-stage non-small-cell lung cancer (ES-NSCLC) remains highly debated. Herein, we utilized spatial proteomics to identify whether any molecular biomarker(s) associate with the efficacy of either modality, in efforts to optimize treatment selection between surgery or SBRT for this population. METHODS: We evaluated biopsy tissue samples from 44 ES-NSCLC patients treated with first-line SBRT (cohort 1) by GeoMx Digital Spatial Profiling (DSP) with a panel of 70 proteins in five spatial molecular compartments: tumor (panCK+), leukocyte (CD45+), lymphocyte (CD3+), macrophage (CD68+), and stroma (α-SMA+)...
March 4, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38436543/macrophage-migration-inhibitory-factor-mif-predicts-survival-in-patients-with-clear-cell-renal-cell-carcinoma
#24
JOURNAL ARTICLE
Martyna Parol-Kulczyk, Justyna Durślewicz, Laura Blonkowska, Radosław Wujec, Arkadiusz Gzil, Daria Piątkowska, Joanna Ligmanowska, Dariusz Grzanka
Clear cell renal cell carcinoma (ccRCC) is one of the most common subtypes of renal cancer, with 30% of patients presenting with systemic disease at diagnosis. This aggressiveness is a consequence of the activation of epithelial-mesenchymal transition (EMT) caused by many different inducers or regulators, signaling cascades, epigenetic regulation, and the tumor environment. Alterations in EMT-related genes and transcription factors are associated with poor prognosis in ccRCC. EMT-related factors suppress E-cadherin expression and are associated with tumor progression, local invasion, and metastasis...
March 2024: Journal of Pathology. Clinical Research
https://read.qxmd.com/read/38416565/elevated-mif-identified-by-multiple-cytokine-analyses-facilitates-macrophage-m2-polarization-contributing-to-postoperative-recurrence-in-chronic-rhinosinusitis-with-nasal-polyps
#25
JOURNAL ARTICLE
S Xie, Z Tong, J Zhang, C Yang, W Jiang, H Zhang
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by tissue heterogeneity and high postoperative recurrence risk. This study aims to employ cytokine analyses to identify serum biomarkers associated with postoperative CRSwNP recurrence and elucidate underlying recurrent mechanisms. METHODS: A prospective cohort study was conducted on CRSwNP patients undergoing functional endoscopic sinus surgery. Serum and tissue samples were collected and analyzed for multiple cytokines...
February 28, 2024: Rhinology
https://read.qxmd.com/read/38406786/rebastinib-attenuates-liver-injury-following-cecal-ligation-and-puncture-in-male-mice
#26
JOURNAL ARTICLE
Aula Zaini, Hayder Edrees Jawad, Dhefaf Hameed Al-Mudhafar, Najah Rayish Hadi
Sepsis remains a public health issue with high morbidity and mortality. Liver injury due to sepsis is associated with poor outcomes and an increased risk of death among septic patients. Rebastinib is a small molecule inhibiting the Tie2 receptor and vascular endothelial growth factor receptor-2 (VEGFR2). The current study aimed to reveal the potential protective impact of Rebastinib against sepsis-induced liver injury. Twenty-four adult male mice were allocated into four groups (six per group) as follows: Sham group was exposed to anesthesia and laparotomy with no cecal ligation and puncture procedure (CLP); CLP group was subjected CLP procedure; vehicle-treated group was pretreated with vehicle (oral route) one hour prior to CLP procedure; Rebastinib group was pretreated with oral Rebastinib one hour before induction of CLP...
November 2023: Journal of Medicine and Life
https://read.qxmd.com/read/38405130/mettl3-mediated-linc00475-alternative-splicing-promotes-glioma-progression-by-inducing-mitochondrial-fission
#27
JOURNAL ARTICLE
Yaping Yan, Ailing Luo, Shanshan Liu, Mansi Cai, Xiaodan Liu, Xiaohong Zhang, Siyi Zhang, Yu Liu, Jiamin Zeng, Xinke Xu, Na Zhang, Zhuorong Zhang, Yingyi Xu, Jing He, Xiaoping Liu
Mitochondrial fission promotes glioma progression. The function and regulation mechanisms of lncRNAs in glioma mitochondrial fission are unclear. The expression of LINC00475 and its correlation with clinical parameters in glioma were analyzed using bioinformatics. Then, in vitro and in vivo assays were performed to explore the function of spliced variant LINC00475 (LINC00475-S) in gliomas. To explore the mechanisms, RNA-seq, MeRIP, RIP, pulldown-IP, dCas9-ALKBH5 editing system, LC/MS, and Western blotting were utilized...
2024: Research: a science partner journal
https://read.qxmd.com/read/38397531/understanding-the-interaction-between-nanomaterials-originated-from-high-temperature-processed-starch-myristic-acid-and-human-monocyte-cells
#28
JOURNAL ARTICLE
Vaiyapuri Subbarayan Periasamy, Jegan Athinarayanan, Ali A Alshatwi
High-temperature cooking approaches trigger many metabolically undesirable molecule formations, which pose health risks. As a result, nanomaterial formation has been observed while cooking and reported recently. At high temperatures, starch and myristic acid interact and lead to the creation of nanomaterials (cMS-NMs). We used a non-polar solvent chloroform to separate the nanomaterials using a liquid-liquid extraction technique. The physico-chemical characterization was carried out using dynamic light scattering (DLS), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and Fourier-transform infrared spectroscopy (FTIR)...
February 12, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38396375/blocking-the-self-destruct-program-of-dopamine-neurons-through-macrophage-migration-inhibitory-factor-nuclease-inhibition
#29
JOURNAL ARTICLE
Jaimin Patel, Valina L Dawson, Ted M Dawson
Parkinson's disease (PD) is a progressive neurodegenerative condition that pathognomonically involves the death of dopaminergic neurons in the substantia nigra pars compacta, resulting in a myriad of motor and non-motor symptoms. Given the insurmountable burden of this disease on the population and healthcare system, significant efforts have been put forth toward generating disease modifying therapies. This class of treatments characteristically alters disease course, as opposed to current strategies that focus on managing symptoms...
February 23, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38395221/cerebrospinal-fluid-inflammatory-markers-to-differentiate-between-neonatal-bacterial-meningitis-and-sepsis-a-prospective-study-of-diagnostic-accuracy
#30
JOURNAL ARTICLE
Nina S Groeneveld, Sabine E Olie, Douwe H Visser, Linde Snoek, Diederik van de Beek, Matthijs C Brouwer, Merijn W Bijlsma
OBJECTIVES: We evaluated the diagnostic accuracy of cerebrospinal fluid (CSF) inflammatory markers for diagnosing bacterial meningitis in neonates with sepsis and/or meningitis. METHODS: Cases were identified from a prospective multicenter study including patients aged 0-3 months with Group B Streptococcal (GBS) or Escherichia coli culture positive sepsis/meningitis. CSF CXCL-10, MDC, IL6, Il-8, IL-10, TNF- α, MIF, IL-1RA, CXCL13, IL-1β, CRP and procalcitonin concentrations were measured with Luminex technology...
February 21, 2024: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/38386050/granzyme-b-%C3%A2-b-cells-detected-by-single-cell-sequencing-are-associated-with-prognosis-in-patients-with-intrahepatic-cholangiocarcinoma-following-liver-transplantation
#31
JOURNAL ARTICLE
Ji-Qiao Zhu, Ying Zhu, Man Qi, Ye Zeng, Zhen-Jia Liu, Cheng Ding, Tao Zhang, Xian-Liang Li, Dong-Dong Han, Qiang He
B cells possess anti-tumor functions mediated by granzyme B, in addition to their role in antigen presentation and antibody production. However, the variations in granzyme B+ B cells between tumor and non-tumor tissues have been largely unexplored. Therefore, we integrated 25 samples from the Gene Expression Omnibus database and analyzed the tumor immune microenvironment. The findings uncovered significant inter- and intra-tumoral heterogeneity. Notably, single-cell data showed higher proportions of granzyme B+ B cells in tumor samples compared to control samples, and these levels were positively associated with disease-free survival...
February 22, 2024: Cancer Immunology, Immunotherapy: CII
https://read.qxmd.com/read/38384515/salivary-and-serum-nitric-oxide-synthase-macrophage-inflammatory-protein-1-alpha-and-macrophage-migration-inhibitory-factor-levels-in-periodontal-disease
#32
JOURNAL ARTICLE
Fatma Oner, Faruk Cagri Onat, Yerda Ozkan Karasu
OBJECTIVE: Periodontal disease is multifactorial inflammatory disease involving both gingivitis and periodontitis. Inducible nitric oxide synthase (iNOS), macrophage inflammatory protein 1 alpha (MIP-1α) and macrophage migration inhibitory factor (MIF) are mediators contributing to the progression of periodontal diseases with distinct functions. The aim of this study is to evaluate the local and systemic iNOS, MIP-1α and MIF concentrations in patients having periodontal disease with different severities...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38380335/integrin-cd11c-regulates-b-cell-homeostasis
#33
JOURNAL ARTICLE
Lifei Hou, Yi-Cheng Sin, Yue Chen, Koichi Yuki
CD11c is widely known as a cell surface marker for dendritic cells, but we recently showed that it regulates neutrophil and T cell functions. Because we found that CD11c knockout (KO) mice had lower blood B cell counts, we characterized B cell profile in developmental stages. We found that CD11c KO recirculating and mature B cells was significantly fewer compared with wild type, associated with exaggerated proliferation and apoptosis. Because they did not express CD11c, we sought for the possibility of CD11c-mediated non-intrinsic regulation of B cell proliferation and apoptosis...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38379319/urinary-exosomal-mirna-451a-can-be-used-as-a-potential-noninvasive-biomarker-for-diagnosis-reflecting-tubulointerstitial-damage-and-therapeutic-response-in-iga-nephropathy
#34
JOURNAL ARTICLE
Qiong Zhang, Yan Zhao, Yankun Luo, Songjia Guo, Haizhu Hou, Xiaoli Han, Yun Zhou
To investigate the potential clinical value of urinary exosomal (uE) miR-451a as a biomarker for IgAN, urinary exosomes were isolated from 40 patients with IgAN, 30 patients with primary renal diseases without IgA as disease controls (non-IgAN group) and 21 healthy controls (HCs). The expression of miR-451a within exosomes was examined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). uE miR-451a was significantly upregulated in patients with IgAN compared to non-IgAN and HCs. The uE miR-451a level was positively correlated with the change in eGFR and negatively correlated with serum creatinine, urinary macrophage migration inhibitory factor ( MIF), interleukin-6 (IL-6) and tumor necrosis factor (TNF-α)...
December 2024: Renal Failure
https://read.qxmd.com/read/38367848/macrophage-migration-inhibitory-factor-favors-neospora-caninum-infection-in-mice
#35
JOURNAL ARTICLE
Vanessa Resende Souza Silva, Caroline Martins Mota, Lydiane Parreira Maia, Flávia Batista Ferreira, Vanessa Dos Santos Miranda, Neide Maria Silva, Eloísa A Vieira Ferro, José Roberto Mineo, Tiago Wilson Patriarca Mineo
Neospora caninum is a protozoan parasite with worldwide incidence, acting as a major cause of reproductive failures in ruminants and neuromuscular symptoms in dogs. Macrophage Migration Inhibitory Factor (MIF) is produced by several cell types and exhibits a central role in immune responses against intracellular pathogens. The present study aimed to comprehend the role of MIF in the relationship between N. caninum and its host. We used in vivo, in vitro and ex vivo experiments in a model of infection based on genetically deficient mice to analyze the infection kinetics and inflammatory markers...
February 15, 2024: Microbial Pathogenesis
https://read.qxmd.com/read/38367440/significant-biomagnification-of-methylmercury-in-songbird-nestlings-through-a-rice-based-food-web-insights-from-stable-mercury-isotopes
#36
JOURNAL ARTICLE
Zhidong Xu, Qinhui Lu, Dongya Jia, Shenghao Li, Kang Luo, Tongping Su, Zhuo Chen, Guangle Qiu
To elucidate the sources and transfer of mercury (Hg) in terrestrial food chains, particularly in heavily Hg-contaminated rice paddy ecosystems, we collected rice leaves, invertebrates, and Russet Sparrow nestlings from a clear food chain and analyzed the dietary compositions and potential Hg sources using stable Hg isotopes coupled with a Bayesian isotope mixing model (BIMM). Our findings indicated that MeHg exposure is dominant through the dietary route, with caterpillars, grasshoppers, and katydids being the main prey items, while the less provisioned spiders, dragonflies, and mantises contributed the most of the Hg to nestlings...
February 14, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38364514/surface-enhanced-raman-spectroscopy-of-the-filtrate-portions-of-the-blood-serum-samples-of-breast-cancer-patients-obtained-by-using-30%C3%A2-kda-filtration-device
#37
JOURNAL ARTICLE
Hawa Hajab, Ayesha Anwar, Haq Nawaz, Muhammad Irfan Majeed, Najah Alwadie, Sana Shabbir, Arooj Amber, Muhammad Idrees Jilani, Hafiza Faiza Nargis, Muhamad Zohaib, Sidra Ismail, Abida Kamal, Muhammad Imran
Raman spectroscopy is reliable tool for analyzing and exploring early disease diagnosis related to body fluids, such as blood serum, which contain low molecular weight fraction (LMWF) and high molecular weight fraction (HMWF) proteins. The disease biomarkers consist of LMWF which are dominated by HMWF hence their analysis is difficult. In this study, in order to overcome this issue, centrifugal filter devices of 30 kDa were used to obtain filtrate and residue portions obtained from whole blood serum samples of control and breast cancer diagnosed patients...
February 13, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/38347290/identifying-an-aml-prognostic-model-using-10-marker-genes-from-single-cell-transcriptome-and-bulk-transcriptome-analysis
#38
JOURNAL ARTICLE
Fangyuan Zhang, Xiaohua Guo, Lihong Ye, Shicheng Yu
Fanconi anemia (FA) is the predominant hereditary syndrome of bone marrow failure (BMF), distinguished by impairments in DNA repair mechanisms. The deficiency in the FANC pathway, which governs DNA repair and replication rescue, results in aberrant responses to DNA damage in individuals with FA. The objective of this study is to examine the involvement of the FANC core complex in BMF and ascertain nucleolar homeostasis-related genes by conducting transcriptome analysis on primary hematopoietic stem cells obtained from FA patients with FANCA and FANCC variants...
February 12, 2024: Biochemical Genetics
https://read.qxmd.com/read/38340551/macrophage-inhibitory-factor-alters-the-functionality-of-macrophages-and-their-involvement-in-disease-pathogenesis-of-active-generalized-vitiligo-patients
#39
JOURNAL ARTICLE
Nikita Sain, Vishakha Hooda, Ashu Singh, Somesh Gupta, Sudheer Arava, Alpana Sharma
INTRODUCTION: In autoimmune dermatitis patients, a macrophage migration inhibitory factor (MIF) is widely used to determine the severity of the diseases with other clinical parameters. Moreover, in vitiligo, MIF has shown significant positive correlation with the VASI (Vitiligo Area Scoring Index) score of both generalized and localized vitiligo patients. MIF function as pro-inflammatory cytokine and inhibited random migration of macrophages from inflammation loci. Hence, activated macrophage infiltrates promote the diseases pathogenesis...
February 9, 2024: Cytokine
https://read.qxmd.com/read/38336189/single-cell-rna-sequencing-reveals-the-mif-ackr3-receptor-ligand-interaction-between-icafs-and-tumor-cells-in-esophageal-squamous-cell-carcinoma
#40
JOURNAL ARTICLE
Jialu Liang, Kai Lei, Ruihao Liang, Jing Huang, Binhua Tan, Huayue Lin, Minghui Wang
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a malignant tumor of the gastrointestinal tract with a high morbidity and mortality rate. The heterogeneity of ESCC poses challenges in treatment and contributes to the poor prognosis of patients. Therefore, it is crucial to gain a better understanding of the tumor microenvironment (TME) heterogeneity and identify novel therapeutic targets. METHODS: To solve this problem, we performed a single-cell RNA sequencing (scRNA-seq) analysis of ESCC samples obtained from the GEO database...
February 7, 2024: Cellular Signalling
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