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https://www.readbyqxmd.com/read/29350381/macrophage-migration-inhibitory-factor-knockout-attenuates-endotoxin-induced-cardiac-dysfunction-in-mice
#1
Jie Zhang, Xin Zhang, Yuqi Cui, Lianqun Cui, Peng Zhao
BACKGROUND: The accumulated evidence suggests that macrophage migration inhibitory factor (MIF) plays a key role not only in acute and chronic inflammatory diseases but also in cardiovascular disease. The cardiac dysfunction is related to lipopolysaccharide (LPS) in sepsis. AIM: This study was designed to examine whether MIF mediates LPS-induced cardiac dysfunction and address the mechanisms. METHODS: Echocardiography, immunohistochemical analysis, cell shortening/relengthening and intracellular Ca2+ fluorescence evaluation were performed in whole hearts and isolated cardiomyocytes from C57 and MIF knockout mice treated with or without LPS...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29335619/cytokine-mif-enhances-blood-brain-barrier-permeability-impact-for-therapy-in-ischemic-stroke
#2
Yu-Chuan Liu, Yung-Hsu Tsai, Sung-Chun Tang, Houng-Chi Liou, Kai-Hsiang Kang, Horng-Huei Liou, Jiann-Shing Jeng, Wen-Mei Fu
Ischemic stroke is a devastating disease with limited therapeutic options. It is very urgent to find a new target for drug development. Here we found that the blood level of MIF in ischemic stroke patients is upregulated. To figure out the pathological role of MIF in ischemic stroke, both in vitro and in vivo studies were conducted. For in vitro studies, primary cortical neuron cultures and adult rat brain endothelial cells (ARBECs) were subjected to oxygen-glucose deprivation (OGD)/reoxygenation. Middle cerebral artery occlusion (MCAo) rodent models were used for in vivo studies...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29331700/effects-of-macrophage-migration-inhibitory-factor-on-cardiac-reperfusion-injury-in-mice-with-depression-induced-by-constant-darkness
#3
Lu-Yuan Tao, Ming-Yuan Huang, Saroj-Thapa, Jiao-Ni Wang, Shao-Ze Wu, Fei He, Kai-Yu Huang, Yang-Jing Xue, Lingwei-Jin, Lian-Ming Liao, Ji-Fei Tang, Kang-Ting Ji
RATIONALE: Depression is associated with coronary artery disease and increases adverse outcomes and mortality in patients with acute myocardial infarction, but the underlying pathophysiological mechanisms remain unclear. OBJECTIVE: To evaluate the effect of macrophage migration inhibitory factor (MIF) on cardiac ischemia-reperfusion (I/R) injury in mice with constant darkness-induced depression. METHODS AND RESULTS: Twenty C57BL/6 mice (8 weeks old, male) were randomly divided into 2 groups: one group was housed in a 12h light/dark cycle environment (LD) and the other in a constant darkness environment (DD)...
December 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29305986/biological-activities-and-functional-analysis-of-macrophage-migration-inhibitory-factor-in-oncomelania-hupensis-the-intermediate-host-of-schistosoma-japonicum
#4
Shuaiqin Huang, Theerakamol Pengsakul, Yunchao Cao, Mingke Lu, Wenfeng Peng, Jiaojiao Lin, Chongti Tang, Liang Tang
Schistosomiasis is a destructive parasitic zoonosis caused by agents of the genus Schistosoma, which afflicts more than 250 million people worldwide. The freshwater amphibious snail Oncomelania hupensis serves as the obligate intermediate host of Schistosoma japonicum. Macrophage migration inhibitory factor (MIF) has been demonstrated to be a pleiotropic immunoregulatory cytokine and a key signaling molecule involved in adaptive and innate immunity. In the present study, we obtained the full-length cDNA of OhMIF and analyzed the characteristics of the ORF and the peptide sequence in O...
January 3, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29305329/increased-serum-levels-and-promoter-polymorphisms-of-macrophage-migration-inhibitory-factor-in-schizophrenia
#5
Satoshi Okazaki, Akitoyo Hishimoto, Ikuo Otsuka, Yuichiro Watanabe, Shusuke Numata, Shuken Boku, Naofumi Shimmyo, Makoto Kinoshita, Emiko Inoue, Tetsuro Ohmori, Toshiyuki Someya, Ichiro Sora
BACKGROUND: Numerous studies have suggested that an immune system imbalance plays an important role in schizophrenia. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine. It plays multiple roles in various biological processes, including inflammation and neurogenesis. Furthermore, several exhaustive serum proteomic profiling studies have identified MIF as a potential biomarker of schizophrenia. Here, we investigate MIF protein levels in serum and postmortem prefrontal cortex in patients with schizophrenia and controls...
January 2, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29289260/relationship-between-serum-macrophage-migration-inhibitory-factor-level-and-insulin-resistance-high-sensitivity-c-reactive-protein-and-visceral-fat-mass-in-prediabetes
#6
Oktay Bilgir, Belma Gökçen, Ferda Bilgir, Aslı Guler, Mehmet Calan, Arif Yuksel, Behnaz Aslanıpour, Murat Akşit, Giray Bozkaya
BACKGROUND: Growing evidence suggest that macrophage migration inhibitory factor (MIF) plays a vital role in glucose metabolism. We aimed to ascertain whether MIF levels are altered in subjects with prediabetes and also to determine the relationship between MIF and metabolic parameters as well as visceral fat mass. MATERIAL AND METHODS: This cross-sectional study included 40 subjects with prediabetes and 40 age-, body mass index (BMI)- and sex-matched subjects with normal glucose tolerance...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29288690/mifepristone-reduces-hypothalamo-pituitary-adrenal-axis-activation-and-restores-weight-loss-in-rats-subjected-to-dietary-restriction-and-methylphenidate-administration
#7
Rami Bou Khalil, Viviane Smayra, Youakim Saliba, Joelle Hajal, Jules-Joël Bakhos, Lama Souaiby, Sami Richa, Jean Tamraz, Nassim Farès
This study evaluates the efficacy of mifepristone on weight restoration in rats subjected to dietary restriction and methylphenidate administration. 25 female rats aged between 9 and 12 months were divided into 2 groups: 5 controls (exposed only to dietary restriction) and 20 rats that were administered 5 mg/kg/d of methylphenidate before meal exposure, for 36 days. Among rats who responded to methylphenidate (weight loss of 15-25%) weeks after its administration, a group of 6 rats continued to receive only methylphenidate ("Met" group), and another group received 10 mg/kg/d of mifepristone in addition to methylphenidate for 18 days ("Met+Mif" group; n = 6)...
December 27, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29284449/experimental-research-on-the-relationship-between-the-stiffness-and-the-expressions-of-fibronectin-proteins-and-adaptor-proteins-of-rat-trabecular-meshwork-cells
#8
Chuan Wang, Lin Li, Zhicheng Liu
BACKGROUND: Trabecular meshwork (TM) plays an important role in maintaining normal intraocular pressure (IOP). Studies have shown that glaucomatous TM tissues are stiffer than those of normal tissue. The high expression of fibronectin protein (FN) and adaptor protein (LNK) may be related to high resistance to aqueous humor outflow as well as high IOP. Our concern is what factors lead to the variation of the stiffness of trabecular tissue/cells. METHODS: Atomic force microscope (AFM) and Western blot (WB) analysis were applied to test TM cells of rats cultured with different concentrations of dexamethasone (DEX) and mifepristone (MIF)...
December 29, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29275011/red-blood-cells-the-primary-reservoir-of-macrophage-migration-inhibitory-factor-in-whole-blood
#9
Elisabeth Karsten, Cameron J Hill, Benjamin R Herbert
Red blood cells are widely accepted to be inert carriers of oxygen and haemoglobin, but there is growing evidence that they play a much more critical role in immune function. Macrophage migration inhibitory factor (MIF) is a key cytokine in disease with additional oxido-reductase activity, which aids in managing oxidative stress. Although two studies have reported the presence of MIF in red blood cells, no study has quantified the levels of this protein. In this study, freshly isolated plasma, platelets, leukocytes, and red blood cells from healthy individuals were collected and the concentration of MIF was determined using an enzyme linked immunosorbent assay...
December 21, 2017: Cytokine
https://www.readbyqxmd.com/read/29274331/pharmacokinetics-disease-modifying-activity-and-safety-of-an-experimental-therapeutic-targeting-an-immunological-isoform-of-macrophage-migration-inhibitory-factor-in-rat-glomerulonephritis
#10
Werner Höllriegl, Alexander Bauer, Bernhard Baumgartner, Barbara Dietrich, Patrice Douillard, Randolf J Kerschbaumer, Gerald Höbarth, Jeffrey S McKee, Alexander Schinagl, Frederick W K Tam, Michael Thiele, Alfred Weber, Martin Wolfsegger, Marietta Turecek, Eva-Maria Muchitsch, Friedrich Scheiflinger, Helmut Glantschnig
New therapeutic agents are needed to overcome the toxicity and suboptimal efficacy observed in current treatment of glomerulonephritis (GN). BaxB01 is a fully human monoclonal antibody targeting a disease-related immunologically distinct isoform of Macrophage migration Inhibitory Factor (MIF), designated oxidized MIF (oxMIF) and locally expressed in inflammatory conditions. We report the pharmacokinetic profile of BaxB01, and its dose and exposure-related disease-modifying activity in experimentally induced rat GN...
December 20, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29259749/adding-a-hydrogen-bond-may-not-help-naphthyridinone-vs-quinoline-inhibitors-of-macrophage-migration-inhibitory-factor
#11
Thomas K Dawson, Pawel Dziedzic, Michael J Robertson, José A Cisneros, Stefan G Krimmer, Ana S Newton, Julian Tirado-Rives, William L Jorgensen
Coordination of the ammonium group of Lys32 in the active site of human macrophage migration inhibitory factor (MIF) using a 1,7-naphthyridin-8-one instead of a quinoline is investigated. Both gas- and aqueous-phase DFT calculations for model systems indicate potential benefits for the added hydrogen bond with the lactam carbonyl group, while FEP results are neutral. Three crystal structures are reported for complexes of MIF with 3a, 4a, and 4b, which show that the desired hydrogen bond is formed with O-N distances of 2...
December 14, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29250927/possible-role-of-interleukin-17-and-macrophage-migration-inhibitory-factor-in-cutaneous-warts
#12
Mohammed Abu El-Hamd, Hanan A Assaf, Essam A Nada
BACKGROUND/OBJECTIVES: Cutaneous warts (CW), or verrucae, are benign proliferation of skin that result from infection with human papilloma viruses. Cellular immune reactivity plays a significant role in wart regression. The aim of this study was to elucidate the cellular immune status of patients with CW through measurements of their serum levels of interleukin-17 (IL-17) and macrophage migration inhibitory factor (MIF,) and, identify the possible role of IL-17 and MIF in CW. We assessed serum IL-17 and MIF levels in patients with different forms of CW and compare the results with controls...
December 18, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29248703/sequential-samples-reveal-significant-variation-of-mercury-isotope-ratios-during-single-rainfall-events
#13
Shengliu Yuan, Jiubin Chen, Hongming Cai, Wei Yuan, Zhongwei Wang, Qiang Huang, Yujie Liu, Xingyang Wu
Although the investigation of mercury (Hg) isotopes in precipitation has largely improved our knowledge of the source and transformation of Hg in the atmosphere, rainwater investigated in previous studies were integrated samples collected over an event and could obscure key information about the physiochemical transformation and deposition dynamics of Hg (and its isotopes) in short precipitation events. In this study, we investigated Hg isotopic composition of filtered (HgF) and particulate Hg (HgPM) in sequential rain samples from three single rainfall events in Guiyang, China...
December 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29247897/post-translational-regulation-of-macrophage-migration-inhibitory-factor-basis-for-functional-fine-tuning
#14
REVIEW
Lisa Schindler, Nina Dickerhof, Mark B Hampton, Jürgen Bernhagen
Macrophage migration inhibitory factor (MIF) is a chemokine-like protein and an important mediator in the inflammatory response. Unlike most other pro-inflammatory cytokines, a number of cell types constitutively express MIF and secretion occurs from preformed stores. MIF is an evolutionarily conserved protein that shows a remarkable functional diversity, including specific binding to surface CD74 and chemokine receptors and the presence of two intrinsic tautomerase and oxidoreductase activities. Several studies have shown that MIF is subject to post-translational modification, particularly redox-dependent modification of the catalytic proline and cysteine residues...
December 6, 2017: Redox Biology
https://www.readbyqxmd.com/read/29247872/proteomic-analysis-shows-constitutive-secretion-of-mif-and-p53-associated-activity-of-cox-2-lung-fibroblasts
#15
Mandar Dave, Abul B M M K Islam, Roderick V Jensen, Agueda Rostagno, Jorge Ghiso, Ashok R Amin
The differential expression of two closely-associated cyclooxygenase isozymes, COX-1 and COX-2, exhibited functions beyond eicosanoid metabolism. We hypothesized that COX-1 or COX-2 knockout lung fibroblasts may display altered protein profiles which may allow us to further differentiate the functional roles of these isozymes at the molecular level. Proteomic analysis shows constitutive production of macrophage migration inhibitory factor (MIF) in lung fibroblasts derived from COX-2-/- but not wild-type (WT) or COX-1-/- mice...
December 13, 2017: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/29239244/roles-of-macrophage-migration-inhibitory-factor-in-polymyositis-inflammation-and-regeneration
#16
Yu-Qiong Zou, Wei-Dong Jin, Ya-Song Li
Objective To elucidate the clinical significance of macrophage migration inhibitory factor (MIF) serum concentration in patients with polymyositis. Methods Thirty-six patients with polymyositis were enrolled. Serum samples were obtained and stored to detect MIF and interleukin (IL)-6 using commercially available enzyme-linked immunosorbent assay kits. The relationships between these cytokines and clinical data were analyzed. Results The serum MIF concentration was significantly lower in patients in remission (34...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29238378/association-of-macrophage-migration-inhibitory-factor-gene-polymorphisms-with-chronic-periodontitis-in-a-south-eastern-iranian-population
#17
Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb, Mohammad Hashemi, Somayeh Ansarimoghaddam, Bita Moudi, Nadia Sheibak
Background: Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator. It plays a vital role in immune response against the oral disease. MIF is a regulator of innate immunity, and bacterial antigens can stimulate serum level of this protein. In experimental gingivitis, the expression level of MIF increases and this increment positively correlates with oral plaque index. The single nucleotide polymorphisms in the gene encoding the MIF protein can control the function of MIF...
November 2017: Dental Research Journal
https://www.readbyqxmd.com/read/29234429/effects-of-jiawei-shaoyao-gancao-decoction-and-its-drug-containing-serum-on-proliferation-apoptosis-and-ultrastructure-of-human-adenomyosis-foci-cells
#18
Yu-Yan Zeng, Kun-Yin Li
Objective: The present study aimed to investigate the effects of Jiawei Shaoyao-Gancao Decoction (JSGD) and its drug-containing serum (CDS) on the proliferation, apoptosis, and ultrastructure of human adenomyosis foci cells. Methods: Primary cultures of human adenomyosis foci cells were prepared from hard uterine lesions of adenomyosis patients. The cells were treated with JSGD (10 and 20 mg/ml), CDS, and mifepristone (MIF) for 24 or 48 h. Cell proliferation was detected using CCK-8 assay, cell apoptosis was measured by flow cytometry, and the cell ultrastructure was observed by transmission electron microscopy (TEM)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29227009/fetal-liver-injury-ameliorated-by-migration-inhibitory-factor-inhibition-in-a-rat-model-of-acute-pancreatitis-in-pregnancy
#19
Zheng-Da Guo, Liang Zhao, Peng Wang, Wen-Hong Deng, Qiao Shi, Teng Zuo, Yu-Pu Hong, Wei-Xing Wang
AIM: This study was designed to investigate and assess fetal liver injury in a rat model of acute pancreatitis in pregnancy (APIP) as well as its possible mechanisms and potential therapeutic targets. METHODS: The APIP model was induced by sodium taurocholate in Sprague-Dawley rats during the third trimester. ISO-1, a macrophage migration inhibitory factor (MIF) antagonist, was given before the induction of APIP. In addition, sham-operated rats at later gestation were set as controls...
December 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29224368/immune-response-proteins-as-predictive-biomarkers-of-doxorubicin-induced-cardiotoxicity-in-breast-cancer-patients
#20
Li-Rong Yu, Zhijun Cao, Issam Makhoul, Jaclyn R Daniels, Suzanne Klimberg, Jeanne Y Wei, Jane Pf Bai, Jinong Li, Julia T Lathrop, Richard D Beger, Valentina K Todorova
Cancer treatment with doxorubicin (DOX) can induce cumulative dose-dependent cardiotoxicity. Currently, there are no specific biomarkers that can identify patients at risk during the initial doses of chemotherapy. The aim of this study was to examine plasma cytokines/chemokines and potential cardiovascular biomarkers for the prediction of DOX-induced cardiotoxicity. Plasma samples were collected before (T0), and after the first (T1) and the second (T2) cycles of DOX-based chemotherapy of 27 breast cancer patients, including five patients who presented with >10% decline of left ventricular ejection fraction (LVEF), five patients with LVEF decline of 5-10%, and 17 patients who maintained normal LVEF at the end of chemotherapy (240 mg/m2 cumulative dose of DOX from four cycles of treatment)...
January 1, 2017: Experimental Biology and Medicine
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