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https://www.readbyqxmd.com/read/28929697/-effects-of-berberine-on-serum-inflammatory-factors-and-carotid-atherosclerotic-plaques-in-patients-with-acute-cerebral-ischemic-stroke
#1
Ying Li, Pei Wang, Mei-Jing Chai, Fan Yang, Hong-Shan Li, Jing Zhao, Huan Wang, Dan-Dan Lu
This study aims to analyze the effect of berberine on serum inflammatory factors and carotid atherosclerotic plaques in ppatients with acute cerebral ischemic stroke(AIS). In the study, 120 patients with AIS were randomly divided into berberine group(n=60) and general group (n=60). The 60 cases in the general group were provided with general therapy according to the latest guidelines of diagnosis and treatment of AIS. The berberine group received berberine 300 mg(tid) in addition to the therapy of the general group...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28928022/the-role-of-jab1-a-putative-downstream-effector-of-the-neurotrophic-cytokine-macrophage-migration-inhibitory-factor-mif-in-zebrafish-inner-ear-hair-cell-development
#2
REVIEW
Loren J Weber, Hannah K Marcy, Yu-Chi Shen, Sarah E Tomkovich, Kristina M Brooks, Kelly E Hilk, Kate F Barald
Macrophage migration inhibitory factor (MIF) is a neurotrophic cytokine essential for inner ear hair cell (HC) development and statoacoustic ganglion (SAG) neurite outgrowth, and SAG survival in mouse, chick and zebrafish. Another neurotrophic cytokine, Monocyte chemoattractant protein 1 (MCP1) is known to synergize with MIF; but MCP1 alone is insufficient to support mouse/chick SAG neurite outgrowth or neuronal survival. Because of the relatively short time over which the zebrafish inner ear develops (~30h), the living zebrafish embryo is an ideal system to examine mif and mcp1 cytokine pathways and interactions...
September 16, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28926123/isotopic-and-chemical-characteristics-of-mercury-in-organs-and-tissues-of-fish-in-a-mercury-polluted-lake-evidence-for-fractionation-of-mercury-isotopes-by-physiological-processes
#3
Togwell A Jackson
Organs and tissues of whitefish and trout from mercury (Hg)-polluted Lake Ontario were analysed for Hg isotopes, methylmercury (CH3 Hg(+) ), and inorganic Hg to investigate possible mass-dependent fractionation (MDF) and mass-independent fractionation (MIF) of Hg isotopes by physiological processes of the fish. Isotope signatures of different body parts were defined by δ-values of (198) Hg/(202) Hg, (199) Hg/(202) Hg, (200) Hg/(202) Hg, and (201) Hg/(202) Hg ratios and by Δ-values representing effects of MIF on (199) Hg/(202) Hg and (201) Hg/(202) Hg ratios...
September 19, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28923927/mif-and-d-dt-are-potential-disease-severity-modifiers-in-male-ms-subjects
#4
Gil Benedek, Roberto Meza-Romero, Kelley Jordan, Ying Zhang, Ha Nguyen, Gail Kent, Jia Li, Edwin Siu, Jenny Frazer, Marta Piecychna, Xin Du, Antoine Sreih, Lin Leng, Jack Wiedrick, Stacy J Caillier, Halina Offner, Jorge R Oksenberg, Vijayshree Yadav, Dennis Bourdette, Richard Bucala, Arthur A Vandenbark
Little is known about mechanisms that drive the development of progressive multiple sclerosis (MS), although inflammatory factors, such as macrophage migration inhibitory factor (MIF), its homolog D-dopachrome tautomerase (D-DT), and their common receptor CD74 may contribute to disease worsening. Our findings demonstrate elevated MIF and D-DT levels in males with progressive disease compared with relapsing-remitting males (RRMS) and female MS subjects, with increased levels of CD74 in females vs. males with high MS disease severity...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28919555/disturbances-of-systemic-and-hippocampal-insulin-sensitivity-in-macrophage-migration-inhibitory-factor-mif-knockout-male-mice-lead-to-behavioral-changes-associated-with-decreased-psa-ncam-levels
#5
Ana Djordjevic, Biljana Bursać, Nataša Veličković, Ljupka Gligorovska, Djurdjica Ignjatović, Mirko Tomić, Gordana Matić
Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine well known for its role in inflammation enhancement. However, a growing body of evidence is emerging on its role in energy metabolism in insulin sensitive tissues such as hippocampus, a brain region implicated in cognition, learning and memory. We hypothesized that genetic deletion of MIF may result in the specific behavioral changes, which may be linked tо impairments in brain or systemic insulin sensitivity by possible changes of the hippocampal synaptic plasticity...
September 14, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28919396/protective-effect-of-chlorogenic-acid-on-the-inflammatory-damage-of-pancreas-and-lung-in-mice-with-l-arginine-induced-pancreatitis
#6
Tatsuya Ohkawara, Hiroshi Takeda, Jun Nishihira
AIMS: Pancreatitis is characterized by inflammatory disease with severe tissue injury in pancreas, and the incidence of pancreatitis has been recently increasing. Although several treatments of acute pancreatitis have been developed, some patients have been resistant to current therapy. Chlorogenic acid (CGA) is one of the polyphenols, and is known to have an anti-inflammatory effect. In this study, we investigated the effects of CGA on experimental pancreatitis in mice. MATERIALS AND METHODS: Pancreatitis was induced by twice injection of l-arginine (5g/kg body weight)...
September 14, 2017: Life Sciences
https://www.readbyqxmd.com/read/28917796/simultaneous-phase-inversion-and-imprinting-based-sensor-for-highly-sensitive-and-selective-detection-of-bisphenol-a
#7
Qian Yang, Xiaqing Wu, Hailong Peng, Longwen Fu, Xingliang Song, Jinhua Li, Hua Xiong, Lingxin Chen
A novel recognition element of molecularly imprinted films (MIFs) was synthesized by wet phase inversion (WPI) on the surface of Ti/TiO2 electrode for highly selective and sensitive electrochemical detection of bisphenol A (BPA). The Ti/TiO2/MIFs sensor was constructed by casting the precursor poly(acrylonitrile-co-acrylic acid) (p(AN-co-AA)) in dimethyl sulfoxide containing template molecule BPA onto the electrode and then immersing into water, resulting in simultaneous p(AN-co-AA) precipitation and BPA imprinting via the facile WPI...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28912189/associations-between-circulating-macrophage-migration-inhibitory-factor-mif-levels-and-rheumatoid-arthritis-and-between-mif-gene-polymorphisms-and-disease-susceptibility-a-meta-analysis
#8
Sang-Cheol Bae, Young Ho Lee
AIM: To systematically review evidence regarding the relationship between circulating macrophage migration inhibitory factor (MIF) levels and rheumatoid arthritis (RA), and the association between MIF gene polymorphisms and RA susceptibility. DESIGN: We performed a meta-analysis on data of serum/plasma MIF levels in patients with RA and in controls, and on associations between the MIF-173 C/G and -794CATT5-8 polymorphisms and RA susceptibility. PATIENTS: Twelve studies, comprising a total of 362 RA cases and 531 controls evaluated for MIF levels, and 2367 RA cases and 2395 controls evaluated for MIF polymorphisms, were included...
September 14, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28906008/role-of-macrophage-migration-inhibitory-factor-mif-in-the-effects-of-oxidative-stress-on-human-retinal-pigment-epithelial-cells
#9
Ji-Ae Ko, Yasuyuki Sotani, Diah Gemala Ibrahim, Yoshiaki Kiuchi
Proliferative vitreoretinopathy (PVR) is the major cause of treatment failure in individuals who undergo surgery for retinal detachment. The epithelial-mesenchymal transition (EMT) in retinal pigment epithelium (RPE) cells contributes to the pathogenesis of PVR. Oxidative stress is thought to play a role in the progression of retinal diseases including PVR. We have now examined the effects of oxidative stress on the EMT and related processes in the human RPE cell line. We found that H2 O2 induced the contraction of RPE cells in a three-dimensional collagen gel...
September 14, 2017: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/28905103/influence-of-the-mif-polymorphism-173g%C3%A2-%C3%A2-c-on-turkish-postmenopausal-women-with-osteoporosis
#10
A Z Ozsoy, N Karakus, S Tural, S Yigit, N Kara, G Alayli, M K Tumer, O Kuru
BACKGROUND: MIF, a proinflammatory cytokine, contributes to the pathogenesis of acute, chronic, and autoimmune inflammatory disorders and balances the suppressive effect of glucocorticoids on the immune system. There is an interaction between bone metabolism and the immune system via the production of cytokines. We aimed to analyze the relationship between the MIF gene -173G > C promoter polymorphism and osteoporosis. METHODS: In this case-control study performed in a university hospital, 286 samples (136 women with osteoporosis and 150 healthy age-matched controls) participated...
September 13, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28900389/cerebellar-atrophy-and-changes-in-cytokines-associated-with-the-cacna1a-r583q-mutation-in-a-russian-familial-hemiplegic-migraine-type-1-family
#11
Svetlana F Khaiboullina, Elena G Mendelevich, Leyla H Shigapova, Elena Shagimardanova, Guzel Gazizova, Alexey Nikitin, Ekaterina Martynova, Yuriy N Davidyuk, Enver I Bogdanov, Oleg Gusev, Arn M J M van den Maagdenberg, Rashid A Giniatullin, Albert A Rizvanov
Background: Immune mechanisms recently emerged as important contributors to migraine pathology with cytokines affecting neuronal excitation. Therefore, elucidating the profile of cytokines activated in various forms of migraine, including those with a known genetic cause, can help in diagnostic and therapeutic approaches. Methods: Here we (i) performed exome sequencing to identify the causal gene mutation and (ii) measured, using Bio-Plex technology, 22 cytokines in serum of patients with familial migraine (two with hemiplegic migraine and two with migraine with aura) from a Russian family that ethnically belongs to the Tatar population...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28898234/circulating-cytokines-and-small-molecules-follow-distinct-expression-patterns-in-acute-myeloid-leukaemia
#12
Mirazul Islam, Elsa Haniffah Mohamed, Ezalia Esa, Nor Rizan Kamaluddin, Shamsul Mohd Zain, Yuslina Mat Yusoff, Yassen Assenov, Zahurin Mohamed, Zubaidah Zakaria
BACKGROUND: Although aberrant expression of cytokines and small molecules (analytes) is well documented in acute myeloid leukaemia (AML), their co-expression patterns are not yet identified. In addition, plasma baselines for some analytes that are biomarkers for other cancers have not been previously reported in AML. METHODS: We used multiplex array technology to simultaneously detect and quantify 32 plasma analyte (22 reported analytes and 10 novel analytes) levels in 38 patients...
September 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28865129/effects-of-long-term-hypoxia-in-human-chondrosarcoma-cells
#13
J Piltti, J Bygdell, C J Qu, M J Lammi
The cell-based therapies could be potential methods to treat damaged cartilage tissues. Instead of native hyaline cartilage, the current therapies generate mainly weaker fibrocartilage-type of repair tissue. A correct microenvironment influences the cellular phenotype, and together with external factors it can be used, e.g., to aid the differentiation of mesenchymal stem cells to defined types of differentiated adult cells. In this study, we investigated the effect of long-term exposure to 5% low oxygen atmosphere on human chondrosarcoma HCS-2/8 cells...
September 2, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28861347/association-of-the-macrophage-migration-inhibitory-factor-promoter-polymorphisms-with-benign-lymphoepithelial-lesion-of-lacrimal-gland
#14
Qin-Jian Li, Peng-Xiang Zhao, Xu-Juan Zhang, Yang Yi, Dan-Ying Cheng, Jian-Min Ma, Xue-Mei Ma
AIM: To identify the association of the macrophage migration inhibitory factor (MIF) gene polymorphism with the susceptibility of benign lymphoepithelial lesions (BLEL) of the lacrimal gland. METHODS: A total of 40 BLEL of lacrimal gland cases were matched with 40 healthy subjects (HS). Extraction the plasma and whole blood DNA of patients of lacrimal gland BLEL and HS. Elisa and polymerase chain reaction was used to determine in plasma contents of MIF and MIF gene SNP-173G>C and STR -794 CATT(5-8) polymorphism, respectively...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28846570/macrophage-migration-inhibitory-factor-induced-autophagy-contributes-to-thrombin-triggered-endothelial-hyperpermeability-in-sepsis
#15
Chiao-Hsuan Chao, Hong-Ru Chen, Yung-Chun Chuang, Trai-Ming Yeh
Vascular leakage contributes to the high morbidity and mortality associated with sepsis. Exposure of the endothelium to inflammatory mediators, such as thrombin and cytokines, during sepsis leads to hyperpermeability. We recently observed that autophagy, a cellular process for protein turnover, is involved in macrophage migration inhibitory factor (MIF)-induced endothelial hyperpermeability. Even though it is known that thrombin induces endothelial cells to secrete MIF and to increase vascular permeability, the possible role of autophagy in this process is unknown...
August 25, 2017: Shock
https://www.readbyqxmd.com/read/28846192/oncoidal-granular-iron-formation-in-the-mesoarchaean-pongola-supergroup-southern-africa-textural-and-geochemical-evidence-for-biological-activity-during-iron-deposition
#16
A J B Smith, N J Beukes, J Gutzmer, A D Czaja, C M Johnson, N Nhleko
We document the discovery of the first granular iron formation (GIF) of Archaean age and present textural and geochemical results that suggest these formed through microbial iron oxidation. The GIF occurs in the Nconga Formation of the ca. 3.0-2.8 Ga Pongola Supergroup in South Africa and Swaziland. It is interbedded with oxide and silicate facies micritic iron formation (MIF). There is a strong textural control on iron mineralization in the GIF not observed in the associated MIF. The GIF is marked by oncoids with chert cores surrounded by magnetite and calcite rims...
August 28, 2017: Geobiology
https://www.readbyqxmd.com/read/28840536/astilbin-alleviates-sepsis-induced-acute-lung-injury-by-inhibiting-the-expression-of-macrophage-inhibitory-factor-in-rats
#17
Hong-Bo Zhang, Li-Chao Sun, Li-da Zhi, Qian-Kuan Wen, Zhi-Wei Qi, Sheng-Tao Yan, Wen Li, Guo-Qiang Zhang
Sepsis is a systemic inflammatory response syndrome caused by severe infections. Astilbin is a dihydroflavonol derivative found in many medicinal and food plants with multiple pharmacological functions. To investigate the effects of astilbin on sepsis-induced acute lung injury (ALI), cecal ligation and puncture was performed on rats to establish a sepsis-induced ALI model; these rats were then treated with astilbin at different concentrations. Lung injury scores, including lung wet/dry ratio, protein leakage, myeloperoxidase activity, and inflammatory cell infiltration were determined to evaluate the effects of astilbin on sepsis-induced ALI...
August 24, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28830478/chemical-composition-and-evaluation-of-the-antibacterial-and-cytotoxic-activities-of-the-essential-oil-from-the-leaves-of-myracrodruon-urundeuva
#18
Ítalo Diego Rebouças de Araújo, Nayara Coriolano de Aquino, Andreza Conceição Véras de Aguiar Guerra, Renato Ferreira de Almeida Júnior, Renata Mendonça Araújo, Raimundo Fernandes de Araújo Júnior, Kléber Juvenal Silva Farias, José Veríssimo Fernandes, Vânia Sousa Andrade
BACKGROUND: This study evaluated the in vitro activity of essential oil extracted from the leaves of Myracrodruon urundeuva. METHODS: The oil was obtained by hydro-distillation and characterized by Gas Chromatography coupled to Mass Spectrometry (GC-MS) and Gas Chromatography with Flame Ionization Detector (GC-FID). The antibacterial activity was evaluated by the broth microdilution technique and the MIF was determined by using growth indicator CTT (2,3,5-triphenyl-tetrazolium) and CBM in BHI agar...
August 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28827791/candidate-gene-polymorphisms-study-between-human-african-trypanosomiasis-clinical-phenotypes-in-guinea
#19
Justin Windingoudi Kaboré, Hamidou Ilboudo, Harry Noyes, Oumou Camara, Jacques Kaboré, Mamadou Camara, Mathurin Koffi, Veerle Lejon, Vincent Jamonneau, Annette MacLeod, Christiane Hertz-Fowler, Adrien Marie Gaston Belem, Enock Matovu, Bruno Bucheton, Issa Sidibe
BACKGROUND: Human African trypanosomiasis (HAT), a lethal disease induced by Trypanosoma brucei gambiense, has a range of clinical outcomes in its human host in West Africa: an acute form progressing rapidly to second stage, spontaneous self-cure and individuals able to regulate parasitaemia at very low levels, have all been reported from endemic foci. In order to test if this clinical diversity is influenced by host genetic determinants, the association between candidate gene polymorphisms and HAT outcome was investigated in populations from HAT active foci in Guinea...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28815947/olive-oil-phenolics-prevent-oxysterol-induced-pro-inflammatory-cytokine-secretion-and-ros-production-in-human-pbmcs-through-modulation-of-p38-and-jnk-pathways
#20
Gessica Serra, Monica Deiana, Jeremy P E Spencer, Giulia Corona
SCOPE: The aim of the present study was to investigate the ability of extra virgin olive oil (EVOO) polyphenols to counteract the pro-inflammatory effects induced by dietary and endogenous oxysterols in ex-vivo immune cells. METHODS AND RESULTS: Peripheral blood mononuclear cells (PBMCs), separated from the whole blood of healthy donors, were utilised and were stimulated with an oxysterols mixture, in the presence of physiologically relevant concentrations of the EVOO polyphenols, hydroxytyrosol (HT), tyrosol (TYR) and homovanillic alcohol (HVA)...
August 16, 2017: Molecular Nutrition & Food Research
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