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https://www.readbyqxmd.com/read/29773680/macrophage-migration-inhibitory-factor-794-catt-microsatellite-polymorphism-and-risk-of-tuberculosis-a-meta-analysis
#1
Mingbiao Ma, Lvyan Tao, Aihua Liu, Zhang Liang, Jiaru Yang, Yun Peng, Xiting Dai, Ruolan Bai, Zhenhua Ji, Miaomiao Jian, Fukai Bao
Tuberculosis (TB) is a chronic infectious disease that has been threatening public health for many years. Several studies have shown the relationship between the macrophage migration inhibitory factor-794CATT ( MIF-794CATT ) microsatellite polymorphism and susceptibility of tuberculosis ( TB ). However, the results remain inconclusive. Therefore, we aim to find out the impact of MIF-794 CATT microsatellite polymorphism on risk of TB by a comprehensive meta-analysis. We conducted a systematic study search in PubMed,Embase, the Cochrane Library, and the China National Knowledge Infrastructure ( CNKI ) up to October, 2017...
May 17, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29773671/targeted-inhibition-of-cd74-attenuates-adipose-cox-2-mif-mediated-m1-macrophage-polarization-and-retards-obesity-related-adipose-tissue-inflammation-and-insulin-resistance
#2
Pei-Chi Chan, Ting-Ni Wu, Ying-Chuan Chen, Chieh-Hua Lu, Martin Wabitsch, Yu-Feng Tian, Po-Shiuan Hsieh
Adipose tissue (AT) inflammation is crucial to the development of obesity-associated insulin resistance. Our aim was to investigate the contribution of COX-2/MIF-mediated crosstalk between hypertrophic adipocytes and macrophages to the etiology of AT inflammation and involvement of CD74 using human SGBS adipocytes, THP-1 macrophages and mice fed a high-fat (HF) diet. The MIF and CD74 mRNA levels in the adipocytes and SVCs (stromal vascular cells) of white fat were highly correlated with body weight, HOMA-IR and adipose macrophage marker expression levels, especially those in SVCs...
May 17, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29770796/suppression-of-mif-induced-neuronal-apoptosis-may-underlie-the-therapeutic-effects-of-effective-components-of-fufang-danshen-in-the-treatment-of-alzheimer-s-disease
#3
Cheng-Jie Liang, Jia-Huang Li, Zhen Zhang, Ju-Yan Zhang, Shu-Qun Liu, Jie Yang
Fufang Danshen (FFDS or Compound Danshen) consists of three Chinese herbs Danshen (Salviae miltiorrhizae radix et rhizome), Sanqi (Notoginseng radix et rhizome) and Tianranbingpian (Borneolum, or D-borneol), which has been show to significantly improve the function of the nervous system and brain metabolism. In this study we explored the possible mechanisms underlying the therapeutic effects of the combination of the effective components of FFDS (Tan IIA, NG-R1 and Borneol) in the treatment of Alzheimer's disease (AD) based on network pharmacology...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29769287/the-protective-role-of-macrophage-migration-inhibitory-factor-in-acute-kidney-injury-after-cardiac-surgery
#4
Christian Stoppe, Luisa Averdunk, Andreas Goetzenich, Josefin Soppert, Arnaud Marlier, Sandra Kraemer, Jil Vieten, Mark Coburn, Ana Kowark, Bong-Song Kim, Gernot Marx, Steffen Rex, Akinobu Ochi, Lin Leng, Gilbert Moeckel, Andreas Linkermann, Omar El Bounkari, Alexander Zarbock, Jürgen Bernhagen, Sonja Djudjaj, Richard Bucala, Peter Boor
Acute kidney injury (AKI) represents the most frequent complication after cardiac surgery. Macrophage migration inhibitory factor (MIF) is a stress-regulating cytokine that was shown to protect the heart from myocardial ischemia-reperfusion injury, but its role in the pathogenesis of AKI remains unknown. In an observational study, serum and urinary MIF was quantified in 60 patients scheduled for elective conventional cardiac surgery with the use of cardiopulmonary bypass. Cardiac surgery triggered an increase in MIF serum concentrations, and patients with high circulating MIF (>median) 12 hours after surgery had a significantly reduced risk of developing AKI (relative risk reduction, 72...
May 16, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29760351/leptin-aggravates-reflux-esophagitis-by-increasing-tissue-levels-of-macrophage-migration-inhibitory-factor-in-rats
#5
Tsugihiro Murata, Kiyotaka Asanuma, Nobuyuki Ara, Katsunori Iijima, Waku Hatta, Shin Hamada, Naoki Asano, Tomoyuki Koike, Akira Imatani, Atsushi Masamune, Tooru Shimosegawa
Leptin, produced primarily by the adipose tissue, acts as a pro-inflammatory modulator, thereby contributing to the development of obesity-related disease. Although high levels of leptin in the obese are closely related to gastroesophageal reflux disease, the mechanism by which leptin influences esophageal inflammation remains unknown. Macrophage migration inhibitory factor (MIF) is produced by immune cells, such as T lymphocytes and macrophages, and MIF is known to induce the production of tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β) and interleukin 6 (IL-6)...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29759141/elevated-plasma-macrophage-migration-inhibitor-factor-as-a-risk-factor-for-the-development-of-post-stroke-depression-in-ischemic-stroke
#6
Tingting Xu, Shuang Pu, Ying Ni, Mingqing Gao, Xuemei Li, Xianwei Zeng
BACKGROUND: Macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory responses, has been reported to link to the pathophysiology of cardiovascular disease and depression. The aim of this study was to test the possible association between plasma MIF and the development of post-stroke depression (PSD) in Chinese patients with acute ischemic stroke (AIS). METHODS: The first-ever AIS patients who were hospitalized at Affiliated Hospital of Weifang Medical College during the period from November 2015 to September 2017 were included...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29756491/innovative-healthy-lifestyles-school-based-public-private-partnerships-designed-to-curb-the-childhood-obesity-epidemic-globally-lessons-learned-from-the-mondel%C3%A4-z-international-foundation
#7
Rafael Pérez-Escamilla
Public-private partnerships (PPPs) have been recognized as central for addressing the childhood obesity epidemic. However, very few real-world examples have been published documenting the workings of effective PPPs. The objective of this article is to identify the factors that enabled the successful implementation of school-based PPPs focusing mainly on nutrition and physical activity in 7 countries located in Asia (China and India), Africa (South Africa), Europe (Germany, United Kingdom), and Latin America (Brazil and Mexico)...
January 1, 2018: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/29752950/minocycline-suppresses-dengue-virus-replication-by-down-regulation-of-macrophage-migration-inhibitory-factor-induced-autophagy
#8
Yen-Chung Lai, Yung-Chun Chuang, Chih-Peng Chang, Yee-Shin Lin, Guey-Chuen Perng, Han-Chung Wu, Shie-Liang Hsieh, Trai-Ming Yeh
Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection of which there is no licensed therapeutic drug available. Previous studies have shown that minocycline, an antibiotic, can inhibit DENV infection in vitro. However, the mechanism is not fully understood. It is known that macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, is involved in dengue disease development; MIF can induce autophagy, and autophagy can facilitate DENV replication. Therefore, we tested the hypothesis that MIF-induced autophagy is involved in minocycline treatment against DENV infection...
May 9, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29743594/multi-nucleated-cells-use-ros-to-induce-breast-cancer-chemo-resistance-in-vitro-and-in-vivo
#9
Aditya Parekh, Subhayan Das, Sheetal Parida, Chandan Kanta Das, Debabrata Dutta, Sanjaya K Mallick, Pei-Hsun Wu, B N Prashanth Kumar, Rashmi Bharti, Goutam Dey, Kacoli Banerjee, Shashi Rajput, Deblina Bharadwaj, Ipsita Pal, Kaushik Kumar Dey, Yetirajam Rajesh, Bikash Chandra Jena, Angana Biswas, Payel Banik, Anjan K Pradhan, Swadesh K Das, Amit Kumar Das, Santanu Dhara, Paul B Fisher, Denis Wirtz, Gordon B Mills, Mahitosh Mandal
Although there is a strong correlation between multinucleated cells (MNCs) and cancer chemo-resistance in variety of cancers, our understanding of how multinucleated cells modulate the tumor micro-environment is limited. We captured multinucleated cells from triple-negative chemo-resistant breast cancers cells in a time frame, where they do not proliferate but rather significantly regulate their micro-environment. We show that oxidatively stressed MNCs induce chemo-resistance in vitro and in vivo by secreting VEGF and MIF...
May 10, 2018: Oncogene
https://www.readbyqxmd.com/read/29737494/the-effect-of-moderate-weight-loss-with-or-without-1-3-1-6-%C3%AE-glucan-addition-on-subcutaneous-adipose-tissue-inflammatory-gene-expression-in-young-subjects-with-uncomplicated-obesity
#10
Marek Strączkowski, Agnieszka Nikołajuk, Radosław Majewski, Remigiusz Filarski, Magdalena Stefanowicz, Natalia Matulewicz, Monika Karczewska-Kupczewska
PURPOSE: Obesity is characterized by insulin resistance and low-grade systemic and adipose tissue (AT) inflammation. It remains unclear whether beneficial effects of weight loss are related to AT inflammation. We aimed to assess the effect of weight loss during low-calorie diet on insulin sensitivity, AT expression of genes associated with inflammation in young subjects with obesity. Furthermore, we estimated the effects of immunomodulatory (1, 3)(1, 6)-β-glucan (BG) on the above parameters...
May 8, 2018: Endocrine
https://www.readbyqxmd.com/read/29736315/kshv-co-infection-regulates-hpv16-cervical-cancer-cells-pathogenesis-in-vitro-and-in-vivo
#11
Lu Dai, Jing Qiao, Luis Del Valle, Zhiqiang Qin
High-risk human papillomavirus (HPV) infection is the etiological agent of cervical, oral and oropharyngeal cancers. Another oncogenic virus, Kaposi sarcoma-associated herpesvirus (KSHV) can cause several human cancers arising in those immunocompromised patients. KSHV DNA has been detected in the oral cavity and the female genital tract, although its detection rate in cervical samples is relatively low. Therefore, it remains unclear about the role of KSHV co-infection in the development of HPV-related neoplasia...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29736200/adipose-derived-mesenchymal-stem-cell-derived-exosomes-alleviate-overwhelming-systemic-inflammatory-reaction-and-organ-damage-and-improve-outcome-in-rat-sepsis-syndrome
#12
Chia-Lo Chang, Pei-Hsun Sung, Kuan-Hung Chen, Pei-Lin Shao, Chih-Chao Yang, Ben-Chung Cheng, Kun-Chen Lin, Chih-Hung Chen, Han-Tan Chai, Hsueh-Wen Chang, Hon-Kan Yip, Hong-Hwa Chen
This study tested the hypothesis that healthy adipose-derived mesenchymal stem cell (ADMSC)-derived exosomes (HMSCEXO ) and apoptotic (A) (induced by 12 h hypoxia/12 h starvation)-ADMSC-derived exosomes (AMSCEXO ) were comparably effective at alleviating sepsis syndrome [SS; induced by cecal-ligation and puncture (CLP)]-induced systemic inflammation and reduced organ damage and unfavorable outcomes in rats. SD rats were divided into sham control (SC), SS only, SS + HMSCEXO (100 µg intravenous administration 3 h after CLP), and AMSCEXO ...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29731899/expression-of-cd74-in-bladder-cancer-and-its-suppression-in-association-with-cancer-proliferation-invasion-and-angiogenesis-in-ht-1376-cells
#13
Jun-Wei Gai, Wasilijiang Wahafu, Liming Song, Hao Ping, Mingshuai Wang, Feiya Yang, Yinong Niu, Wei Qing, Nianzeng Xing
The aim of the present study was to investigate the expression and potential roles of CD74 in human urothelial cell carcinoma of the bladder (UCB) in vitro and in vivo . CD74 and macrophage migration inhibitory factor (MIF) were located and assayed in normal and UCB samples and cell lines using immunostaining. CD74 was knocked down using CD74 shRNA lentiviral particles in HT-1376 cells. The proliferative, invasive potential and microvessel density (MVD) of knockdown-CD74 HT-1376 cells were analyzed in vitro or in vivo ...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29728137/predictive-potential-of-macrophage-migration-inhibitory-factor-mif-in-patients-with-heart-failure-with-preserved-ejection-fraction-hfpef
#14
Peter Luedike, Georgios Alatzides, Maria Papathanasiou, Martin Heisler, Julia Pohl, Nils Lehmann, Tienush Rassaf
BACKGROUND: Prognostication in heart failure with preserved ejection fraction (HFpEF) is challenging and novel biomarkers are urgently needed. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that plays a crucial role in cardiovascular and various inflammatory diseases. Whether MIF is involved in HFpEF is unknown. METHODS AND RESULTS: Sixty-two patients with HFpEF were enrolled and followed up for 180 days. MIF plasma levels as well as natriuretic peptide (NP) levels were assessed...
May 4, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29726987/admission-macrophage-migration-inhibitory-factor-predicts-long-term-prognosis-in-patients-with-st-elevation-myocardial-infarction
#15
Xiang-Ning Deng, Xin-Yu Wang, Hai-Yi Yu, Shao-Min Chen, Xin-Ye Xu, Wei Huai, Gui-Hua Liu, Qing-Bian Ma, You-Yi Zhang, Anthony M Dart, Xiao-Jun Du, Wei Gao
Background: We previously showed in patients with ST-segment elevated myocardial infarction (STEMI) that admission levels of macrophage migration inhibitory factor (MIF) predict infarct size. It remains unclear whether admission MIF alone or in combination with other biomarkers is useful for risk assessment of acute and chronic clinical outcomes in STEMI patients. Methods and Results: 566 STEMI patients treated with primary percutaneous coronary intervention (PCI) were consecutively recruited...
May 2, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29725632/urinary-biomarkers-to-identify-autosomal-dominant-polycystic-kidney-disease-patients-with-a-high-likelihood-of-disease-progression
#16
A Lianne Messchendorp, Esther Meijer, Wendy E Boertien, Gerwin E Engels, Niek F Casteleijn, Edwin M Spithoven, Monique Losekoot, Johannes G M Burgerhof, Dorien J M Peters, Ron T Gansevoort
Introduction: The variable disease course of autosomal dominant polycystic kidney disease (ADPKD) makes it important to develop biomarkers that can predict disease progression, from a patient perspective and to select patients for renoprotective treatment. We therefore investigated whether easy-to-measure urinary biomarkers are associated with disease progression and have additional value over that of conventional risk markers. Methods: At baseline, inflammatory, glomerular, and tubular damage markers were measured in 24-hour urine collections (albumin, IgG, kidney injury molecule-1 (KIM-1), N -acetyl-β-d-glucosaminidase (NAG), β2 microglobulin (β2MG), heart-type fatty acid binding protein (HFABP), macrophage migration inhibitory factor (MIF), neutrophil gelatinase-associated lipocalin (NGAL), and monocyte chemotactic protein-1 (MCP-1)...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29723777/circulating-macrophage-migration-inhibitory-factor-mif-in-patients-with-heart-failure
#17
Peter Luedike, Georgios Alatzides, Maria Papathanasiou, Martin Heisler, Julia Pohl, Nils Lehmann, Tienush Rassaf
BACKGROUND: Heart failure (HF) is characterized by impaired systolic ejection capacity and/or diastolic filling of the heart, leading to a multisystem disorder. Remote organ failure, systemic inflammation or pulmonary hypertension (PH) are hallmarks of the pathophysiological changes in HF. The Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that is involved in a variety of cardiovascular and inflammatory diseases. Circulating MIF levels and their potential role as a disease marker in the different subgroups of HF have not been investigated yet...
April 30, 2018: Cytokine
https://www.readbyqxmd.com/read/29723624/localization-of-mif-ii-on-mammalian-spermatozoa-a-study-revealing-its-structure-function-and-motility-inhibitory-pathway
#18
Arpita Bhoumik, Sudipta Saha, Pavan V Payghan, Prasanta Ghosh, Sandhya Rekha Dungdung
Motility of spermatozoa is crucial factor for determining semen quality. Here we report Motility inhibitory factor (MIF-II) from goat epididymal plasma, revealing its structure, function, localization and motility inhibitory pathway. Structural characterization with MALDI revealed novelty of this protein while circular dichroism data confirmed its alpha helical nature. Higher dilutions of MIF-II antibody increased cauda sperm motility and induced immature/immotile caput sperm motility as tested microscopically...
April 30, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29720585/de-novo-activating-mutations-drive-clonal-evolution-and-enhance-clonal-fitness-in-kmt2a-rearranged-leukemia
#19
Axel Hyrenius-Wittsten, Mattias Pilheden, Helena Sturesson, Jenny Hansson, Michael P Walsh, Guangchun Song, Julhash U Kazi, Jian Liu, Ramprasad Ramakrishan, Cristian Garcia-Ruiz, Stephanie Nance, Pankaj Gupta, Jinghui Zhang, Lars Rönnstrand, Anne Hultquist, James R Downing, Karin Lindkvist-Petersson, Kajsa Paulsson, Marcus Järås, Tanja A Gruber, Jing Ma, Anna K Hagström-Andersson
Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL) rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remains unclear. Using a retroviral acute myeloid mouse leukemia model, we demonstrate that FLT3 ITD , FLT3 N676K , and NRAS G12D accelerate KMT2A-MLLT3 leukemia onset. Further, also subclonal FLT3 N676K mutations accelerate disease, possibly by providing stimulatory factors. Herein, we show that one such factor, MIF, promotes survival of mouse KMT2A-MLLT3 leukemia initiating cells...
May 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29709763/a-detailed-structural-study-of-cytotoxicity-effect-of-ionic-liquids-on-the-leukemia-rat-cell-line-ipc-81-by-three-dimensional-quantitative-structure-toxicity-relationship
#20
Saeedeh Rahimi Farahani, Mahmoud Reza Sohrabi, Jahan B Ghasemi
In the present study, a very thorough and in-depth three-dimensional quantitative structure-toxicity relationship (3D-QSTR) analysis has been implemented to make a correlation between the structural information of the ionic liquids (ILs) and their cytotoxicity towards Leukemia rat cell line IPC-81, as one of the ILs' toxicological consequences. To do this, alignment free GRid-INdependent Descriptors (GRINDs), which were derived from molecular interaction fields (MIFs), were correlated to the cytotoxicity values by partial least squares (PLS) and support vector regression (SVR)...
April 27, 2018: Ecotoxicology and Environmental Safety
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