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https://www.readbyqxmd.com/read/28647568/hepatocyte-derived-macrophage-migration-inhibitory-factor-mediates-alcohol-induced-liver-injury-in-mice-and-patients
#1
Veronica Marin, Kyle Poulsen, Gemma Odena, Megan R McMullen, Jose Altamirano, Pau Sancho-Bru, Claudio Tiribelli, Juan Caballeria, Natalia Rosso, Ramon Bataller, Laura E Nagy
BACKGROUND & AIMS: Macrophage migration inhibitory factor (MIF) is a multi-potent cytokine that contributes to the inflammatory response to injury. MIF is expressed by multiple cell types; however, the cellular source and actions of MIF in alcoholic liver disease (ALD) are not well known. Here we tested the hypothesis that non-myeloid cells, specifically hepatocytes, are an important cellular source of MIF in ALD. METHODS: MIF expression was measured in HuH7 and differentiated THP-1 cells in response to ethanol...
June 21, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28646884/the-increased-concentration-of-macrophage-migration-inhibitory-factor-in-serum-and-cerebrospinal-fluid-of-patients-with-tick-borne-encephalitis
#2
Sambor Grygorczuk, Miłosz Parczewski, Renata Świerzbińska, Piotr Czupryna, Anna Moniuszko, Justyna Dunaj, Maciej Kondrusik, Sławomir Pancewicz
BACKGROUND: Host factors determining the clinical presentation of tick-borne encephalitis (TBE) are not fully elucidated. The peripheral inflammatory response to TBE virus is hypothesized to facilitate its entry into central nervous system by disrupting the blood-brain barrier with the involvement of a signaling route including Toll-like receptor 3 (TLR3) and pro-inflammatory cytokines macrophage migration inhibitory factor (MIF), tumor necrosis factor-α (TNFα), and interleukin-1 beta (IL-1β)...
June 24, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28642171/macrophage-migration-inhibitory-factor-promotes-osteosarcoma-growth-and-lung-metastasis-through-activating-the-ras-mapk-pathway
#3
Chen Wang, Xing Zhou, Wentao Li, Mingyue Li, Tingyue Tu, Ximing Ba, Yinyu Wu, Zhen Huang, Gentao Fan, Guangxin Zhou, Sujia Wu, Jianning Zhao, Junfeng Zhang, Jiangning Chen
Emerging evidence suggests that the tumour microenvironment plays a critical role in osteosarcoma (OS) development. Thus, cytokine immunotherapy could be a novel strategy for OS treatment. In this study, we explored the role of macrophage migration inhibitory factor (MIF), an important cytokine in OS progression, and investigated the anti-tumour effects of targeting MIF in OS. The results showed that MIF significantly increased in the tissue and serum samples of OS patients and was associated with tumour size, pulmonary metastasis and the survival rate of OS patients...
June 19, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28642136/a-novel-hepatitis-b-virus-derived-cis-acting-sequence-that-enhances-expression-of-transgenes-delivered-by-plasmid-vectors-in-eukaryote-cell-culture-systems
#4
Seoung-Ae Lee, Hong Kim, So-Young Lee, Bum-Joon Kim
We tested the effectiveness of a novel 13-bp hepatitis B virus (HBV)-derived cis-acting element (CAE) (ACCTCGACAAGGC), called the DT2 CAE, in augmenting transgene expression delivered by plasmid vectors in eukaryotic cells. The addition of the DT2 CAE just upstream of the start codon of several different target proteins (luciferase, EGFP, LHB, HBsAg, and MIF) in DNA plasmid constructs enhanced their translation in a posttranscriptional manner, irrespective of cell type (cell lines or primary cells) or promoter (CMV or HBV preS1 promoters), suggesting its feasibility for enhanced protein production in eukaryotic cell systems...
June 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28636550/mif-functions-in-brain-and-glioblastoma
#5
EDITORIAL
Shigeki Ohta, Yutaka Kawakami, Hideyuki Okano
No abstract text is available yet for this article.
June 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28633885/characteristics-of-paraspinal-muscle-spindle-response-to-mechanically-assisted-spinal-manipulation-a-preliminary-report
#6
William R Reed, Joel G Pickar, Randall S Sozio, Michael A K Liebschner, Joshua W Little, Maruti R Gudavalli
OBJECTIVES: The purpose of this preliminary study is to determine muscle spindle response characteristics related to the use of 2 solenoid powered clinical mechanically assisted manipulation (MAM) devices. METHODS: L6 muscle spindle afferents with receptive fields in paraspinal muscles were isolated in 6 cats. Neural recordings were made during L7 MAM thrusts using the Activator V (Activator Methods Int. Ltd., Phoenix, AZ) and/or Pulstar (Sense Technology Inc., Pittsburgh, PA) devices at their 3 lowest force settings...
June 17, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28624489/association-of-genetic-polymorphisms-of-macrophage-inhibitory-factor-mif-and-b-cell-activating-factor-baff-with-the-detection-of-donor-specific-antibodies-in-kidney-allograft-recipients
#7
Youngil Chang, Tariq Shah, David I Min
The posttransplant development of donor specific antibodies (DSA) initiates the antibody mediated rejection (AMR), which is associated with the increased rate of graft loss. One of the characteristics of AMR is the infiltration of innate immune system including macrophages, monocytes, neutrophils or NK cells. Macrophage inhibitory factor (MIF) and B-cell activating factor (BAFF) are well known cytokines that are associated with the activation of the innate immune system which can damage kidney allograft. In this article, the association of the genetic polymorphisms of MIF and BAFF with the development of DSA including Class I and II in kidney transplant patients is investigated...
June 14, 2017: Human Immunology
https://www.readbyqxmd.com/read/28617135/influence-of-personalized-exercise-recommendations-during-rehabilitation-on-the-sustainability-of-objectively-measured-physical-activity-levels-fatigue-and-fatigue-related-biomarkers-in-patients-with-breast-cancer
#8
Philipp Zimmer, Freerk T Baumann, Max Oberste, Joachim Schmitt, Niklas Joisten, Philipp Hartig, Alexander Schenk, Rafaela Kuhn, Wilhelm Bloch, Monika Reuss-Borst
PURPOSE: Only one-third of patients with breast cancer reach the recommended activity level of 15 to 25 MET h/wk. The aim of this study was to determine the influence of personalized exercise recommendations during rehabilitation on patients' physical activity level, fatigue, and self-perceived cognitive function as well as on side effect-associated biomarkers. METHODS: Total metabolic rate, physical activity level, mean MET and steps, fatigue, self-perceived cognitive functioning , and biomarkers (C-reactive protein [CRP], interleukin 6, macrophage migration inhibiting factor [MIF], tumor necrosis factor [TNF]-α, brain-derived neurotrophic factor [BDNF], insulin-like growth factor 1 [IGF1]) were assessed in 60 patients with breast cancer in the aftercare phase before ( t0) and 8 months after ( t1) the intervention...
June 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28615250/an-essential-mif-cd74-signaling-axis-in-kidney-tubular-regeneration-with-prospects-for-precision-medicine-and-pharmacologic-augmentation
#9
Idit Shachar
No abstract text is available yet for this article.
June 14, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28611261/non-neoplastic-portal-vein-thrombosis-in-hcv-cirrhosis-patients-is-it-an-immuno-inflammatory-disorder
#10
Mona Abu El-Makarem, Atef El-Akad, Moustafa Elian, Tahra Sherif, Ragaa El-Shaheed, Aliaa Abd El Fatah, Douaa Sayed, Rania Bakry, Aisha Mahmoud
BACKGROUND AND AIMS: Portal vein thrombosis (PVT) is a critical complication in cirrhotic patients. We explored the role of the activated factor VII-antithrombin (FVIIa-AT) complex and enhanced monocytic tissue factor (TF) expression in the development and prediction of non-neoplastic PVT in cirrhotic patients. MATERIAL AND METHODS: A total of 30 HCV-cirrhosis patients were included in our study. They were compared to 35 cirrhotic patients without PVT, 15 non-cirrhotic patients with PVT, and 15 healthy controls...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28605583/multiple-sulfur-isotope-constraints-on-sources-and-formation-processes-of-sulfate-in-beijing-pm2-5-aerosol
#11
Xiaokun Han, Qingjun Guo, Harald Strauss, Cong-Qiang Liu, Jian Hu, Zhaobing Guo, Rongfei Wei, Marc Peters, Liyan Tian, Jing Kong
Recently air pollution is seriously threatening the health of millions of people in China. Multiple sulfur isotopic compositions of sulfate in PM2.5 samples collected in Beijing are used to better constraining potential sources and formation processes of sulfate aerosol. Here we found the Δ33S values of sulfate in PM2.5 show a pronounced seasonality with positive values in spring, summer and autumn and negative values in winter. Positive Δ33S anomalies are interpreted to result from SO2 photolysis with self-shielding, and may reflect air mass transport between the troposphere and the stratosphere...
June 12, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28597514/macrophage-migration-inhibitory-factor-induces-inflammation-and-predicts-spinal-progression-in-ankylosing-spondylitis
#12
Vidya Ranganathan, Francesco Ciccia, Fanxing Zeng, Ismail Sari, Guiliana Guggino, Janogini Muralitharan, Eric Gracey, Nigil Haroon
OBJECTIVES: To understand the role of macrophage migration inhibitory factor (MIF) in the pathogenesis of Ankylosing Spondylitis (AS). METHODS: AS patients satisfying the modified New York criteria were recruited for the study. Healthy volunteers, rheumatoid arthritis and osteoarthritis patients were included as controls. Based on the annual rate of increase in mSASSS scores, AS patients were classified as progressors or non-progressors. MIF levels were quantitated by ELISA in the serum and synovial fluid...
June 8, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28592042/-the-significances-of-peripheral-neutrophils-cd-55-and-myeloperoxidase-expression-in-patients-with-myeloperoxidase-specific-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis
#13
X L Zhou, M J Zheng, Z W Shuai, L Zhang, M M Zhang, S Y Chen
Objective: To investigate the expression of CD(55) and myeloperoxidase (MPO) on neutrophils in patients with MPO-specific anti-neutrophil cytoplasmic antibody associated vasculitis(MPO-AAV), and analyze the relationship between the expression and clinical manifestation. Methods: Forty untreated patients with active MPO-AAV (patient group) and 30 healthy volunteers (control group) were enrolled in this study. The CD(55) on neutrophils and both membrane and cytoplasmic MPO were detected by flow cytometry. Serum fragment-from the activated complement factor B(Ba) and MPO were measured by ELISA...
June 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28582647/inflammatory-serum-cytokines-and-chemokines-increase-associated-with-the-disease-extent-in-pediatric-langerhans-cell-histiocytosis
#14
Akira Morimoto, Yukiko Oh, Sachie Nakamura, Yoko Shioda, Tomomi Hayase, Toshihiko Imamura, Kazuko Kudo, Shinsaku Imashuku
OBJECTIVE: Langerhans cell histiocytosis (LCH) is characterized by immature dendritic cell proliferation, infiltration of LCH lesions by various inflammatory cells, and a lesional cytokine storm. It is classified into three groups on the basis of disease extent, namely, multisystem with risk-organ involvement (MS+), multisystem without risk-organ involvement (MS-), and single-system (SS) disease. We comprehensively analyzed whether serum levels of cytokines/chemokines reflect the disease extent...
June 2, 2017: Cytokine
https://www.readbyqxmd.com/read/28578664/macrophage-migration-inhibitory-factor-promoter-polymorphisms-794-catt5-8-relationship-with-soluble-mif-levels-in-coronary-atherosclerotic-disease-subjects
#15
Lu Qian, Xiao-Yan Wang, Saroj Thapa, Lu-Yuan Tao, Shao-Ze Wu, Gao-Jiang Luo, Lu-Ping Wang, Jiao-Ni Wang, Jie Wang, Ji Li, Ji-Fei Tang, Kang-Ting Ji
BACKGROUND: We analyzed the relationship of -794 CATT5-8 MIF polymorphisms with soluble MIF in Coronary Atherosclerotic Disease (CAD) patients. METHODS: A total of 256 patients selected, on which 186 normal-coronary and 70 Coronary artery disease subjects, were recruited in the study (Retrospectively registered). Genotyping of -794 CATT5-8 polymorphisms were performed by PCR and DNA sequencing. Serum MIF levels were measured using an ELISA kit. Patients were classified by coronary angiogram, and CAD based on Gensini's integral degree (angiographic scoring system)...
June 2, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28574571/roles-of-macrophage-migration-inhibitory-factor-in-cartilage-tissue-engineering
#16
Yuko Fujihara, Atsuhiko Hikita, Tsuyoshi Takato, Kazuto Hoshi
To obtain stable outcomes in regenerative medicine, understanding and controlling immunological responses in transplanted tissues are of great importance. In our previous study, auricular chondrocytes in tissue-engineered cartilage transplanted in mice were shown to express immunological factors, including macrophage migration inhibitory factor (MIF). Since MIF exerts pleiotropic functions, in this study, we examined the roles of MIF in cartilage regenerative medicine. We made tissue-engineered cartilage consisting of auricular chondrocytes of C57BL/6J mouse, atellocollagen gel and a PLLA scaffold, and transplanted the construct subcutaneously in a syngeneic manner...
June 2, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28572801/elevated-levels-of-proinflammatory-cytokines-in-cerebrospinal-fluid-of-multiple-sclerosis-patients
#17
Timur Khaibullin, Vilena Ivanova, Ekaterina Martynova, Georgy Cherepnev, Farit Khabirov, Evgenii Granatov, Albert Rizvanov, Svetlana Khaiboullina
Multiple sclerosis (MS) is an autoimmune neurodegenerative disease characterized by chronic brain inflammation. Leukocyte infiltration of brain tissue causes inflammation, demyelination, and the subsequent formation of sclerotic plaques, which are a hallmark of MS. Activation of proinflammatory cytokines is essential for regulation of lymphocyte migration across the blood-brain barrier. We demonstrate increased levels of many cytokines, including IL-2RA, CCL5, CCL11, MIF, CXCL1, CXCL10, IFNγ, SCF, and TRAIL, were upregulated in cerebrospinal fluid (CSF), whereas IL-17, CCL2, CCL3, CCL4, and IL-12(p40) were activated in MS serum...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28570891/silica-nanoparticles-inhibit-macrophage-activity-and-angiogenesis-via-vegfr2-mediated-mapk-signaling-pathway-in-zebrafish-embryos
#18
Junchao Duan, Hejing Hu, Lin Feng, Xiaozhe Yang, Zhiwei Sun
The safety evaluation of silica nanoparticles (SiNPs) are getting great attention due to its widely-used in food sciences, chemical industry and biomedicine. However, the adverse effect and underlying mechanisms of SiNPs on cardiovascular system, especially on angiogenesis is still unclear. This study was aimed to illuminate the possible mechanisms of SiNPs on angiogenesis in zebrafish transgenic lines, Tg(fli-1:EGFP) and Albino. SiNPs caused the cardiovascular malformations in a dose-dependent manner via intravenous microinjection...
May 24, 2017: Chemosphere
https://www.readbyqxmd.com/read/28569153/aberrant-monocyte-responses-predict-and-characterize-dengue-virus-infection-in-individuals-with-severe-disease
#19
Yean K Yong, Hong Y Tan, Soe Hui Jen, Esaki M Shankar, Santha K Natkunam, Jameela Sathar, Rishya Manikam, Shamala D Sekaran
BACKGROUND: Currently, several assays can diagnose acute dengue infection. However, none of these assays can predict the severity of the disease. Biomarkers that predicts the likelihood that a dengue patient will develop a severe form of the disease could permit more efficient patient triage and allows better supportive care for the individual in need, especially during dengue outbreaks. METHODS: We measured 20 plasma markers i.e. IFN-γ, IL-10, granzyme-B, CX3CL1, IP-10, RANTES, CXCL8, CXCL6, VCAM, ICAM, VEGF, HGF, sCD25, IL-18, LBP, sCD14, sCD163, MIF, MCP-1 and MIP-1β in 141 dengue patients in over 230 specimens and correlate the levels of these plasma markers with the development of dengue without warning signs (DWS-), dengue with warning signs (DWS+) and severe dengue (SD)...
May 31, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28562118/mif-family-cytokines-in-cardiovascular-diseases-and-prospects-for-precision-based-therapeutics
#20
Pathricia V Tilstam, Dake Qi, Lin Leng, Lawrence Young, Richard Bucala
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with chemokine-like functions that is being increasingly studied in different aspects of cardiovascular disease. MIF was first identified as a proinflammatory and pro-survival mediator within the immune system, and a second structurally related MIF family member, D-dopachrome tautomerase (a.k.a. MIF-2), was reported recently. Both MIF family members are released by myocardium and modulate the manifestations of cardiovascular disease, specifically in myocardial ischemia...
May 31, 2017: Expert Opinion on Therapeutic Targets
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