keyword
MENU ▼
Read by QxMD icon Read
search

MIF

keyword
https://www.readbyqxmd.com/read/27896643/a-novel-signaling-role-for-mir-451-in-esophageal-tumor-microenvironment-and-its-contribution-to-tumor-progression
#1
S Khazaei, N Nouraee, A Moradi, S J Mowla
OBJECTIVE: We evaluated miR-451 expression in serum and tissue samples of esophageal squamous cell carcinoma (ESCC) patients. Then, we examined a secretory role of miR-451 in esophageal tumor microenvironment. METHODS: miR-451 expression was evaluated in 39 serum samples from esophageal SCC patients compared to 39 normal individuals as well as 26 pairs of fresh-frozen tumor and adjacent normal tissues from patients with ESCC, using qRT-PCR. In a co-culture system of human normal fibroblasts (HFSF-PI3) and esophageal cancer cell line (KYSE-30), we evaluated exosomal miR-451 secretion into the conditioned medium (CM) of both cell lines...
November 28, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27893098/vitreal-cytokine-profile-differences-between-eyes-with-epiretinal-membranes-or-macular-holes
#2
Souska Zandi, Christoph Tappeiner, Isabel B Pfister, Alain Despont, Robert Rieben, Justus G Garweg
Purpose: Cytokines play an important role in cell signaling in inflammatory and repair processes, also within the posterior segment of the eye. These molecules are thus implicated in the pathophysiology of several vitreoretinal diseases. In the present study, we compared vitreal cytokine profiles in patients with idiopathic epiretinal membranes (ERMs) and idiopathic full-thickness macular holes (MHs) without epiretinal membranes. Methods: Native vitreal humor was collected during elective pars plana vitrectomy for the treatment of macular pathologies (group 1: ERM; group 2: MH) from patients without any other ocular or systemic disease...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27884769/upregulation-of-cd74-and-its-potential-association-with-disease-severity-in-subjects-with-ischemic-stroke
#3
Liu Yang, Ying Kong, Honglei Ren, Minshu Li, Chang-Juan Wei, Elaine Shi, Wei-Na Jin, Junwei Hao, Arthur A Vandenbark, Halina Offner
Macrophage migration inhibitory factor (MIF) is a key cytokine/chemokine in the activation and recruitment of inflammatory T lymphocytes known to exacerbate experimental stroke severity. MIF effects are mediated through its primary cellular receptor, CD74, the MHC class II invariant chain present on all class II expressing cells, including monocytes, macrophages and dendritic cells (DC). We demonstrated previously that partial MHC class II/peptide constructs (pMHC) can effectively treat mice with experimental stroke, in part through their ability to competitively inhibit MIF/CD74 interactions and downstream signaling...
November 21, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27872288/mif-allele-dependent-regulation-of-the-mif-coreceptor-cd44-and-role-in-rheumatoid-arthritis
#4
Seung-Ah Yoo, Lin Leng, Bum-Joon Kim, Xin Du, Pathricia V Tilstam, Kyung Hee Kim, Jin-Sun Kong, Hyung-Ju Yoon, Aihua Liu, Tian Wang, Yan Song, Maor Sauler, Jurgen Bernhagen, Christopher T Ritchlin, Patty Lee, Chul-Soo Cho, Wan-Uk Kim, Richard Bucala
Fibroblast-like synoviocytes mediate joint destruction in rheumatoid arthritis and exhibit sustained proinflammatory and invasive properties. CD44 is a polymorphic transmembrane protein with defined roles in matrix interaction and tumor invasion that is also a signaling coreceptor for macrophage migration inhibitory factor (MIF), which engages cell surface CD74. High-expression MIF alleles (rs5844572) are associated with rheumatoid joint erosion, but whether MIF signaling through the CD74/CD44 receptor complex promotes upstream autoimmune responses or contributes directly to synovial joint destruction is unknown...
November 21, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27872094/mif-induced-stromal-pkc%C3%AE-il8-is-essential-in-human-acute-myeloid-leukemia
#5
Amina Abdul-Aziz, Manar Shafat, Tarang Mehta, Federica Di Palma, Matthew Lawes, Stuart A Rushworth, Kristian Bowles
Acute myeloid leukemia (AML) cells exhibit a high level of spontaneous apoptosis when cultured in vitro but have a prolonged survival time in vivo, indicating that tissue microenvironment plays a critical role in promoting AML cell survival. In vitro studies have shown that bone marrow-mesenchymal stromal cells (BM-MSC) protect AML blasts from spontaneous and chemotherapy-induced apoptosis. Here we report a novel interaction between AML blasts and BM-MSC which benefits AML proliferation and survival. We initially examined the cytokine profile in cultured human AML compared to AML cultured with BM-MSC and found that macrophage-migration inhibitory factor (MIF) was highly expressed by primary AML, and that interleukin-8 (IL-8) was increased in AML/BM-MSC co-cultures...
November 21, 2016: Cancer Research
https://www.readbyqxmd.com/read/27852364/-the-expression-of-macrophage-migration-inhibitory-factor-in-obstructive-sleep-apnea-hypopnea-syndrome-and-its-injury-to-endothelial-cells
#6
P Yuan, W J Wang, D F Li, Q Ou, X L Gao
Objective: To study the expression of macrophage migration inhibitory factor (MIF) in obstructive sleep apnea hypopnea syndrome (OSAHS) and its injury to endothelial cells. Methods: According to the PSG test results, subjects who were the first time to take PSG examination without treatment (n=71) were divided into a control group (n=20), a mild OSAHS group (n=19), a moderate OSAHS group (n=15) and severe OSAHS group (n=17). For each patients, 4 ml fasting peripheral blood was obtained when PSG was finished around 6: 30 in the next morning, and the MIF level in plasma was detected with the ELISA method...
November 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27848101/-evaluation-of-the-benefit-of-different-complementary-exams-in-the-search-for-a-tb-diagnosis-algorithm-for-hiv-patients-put-on-art-in-niamey-niger
#7
E Ouedraogo, G Lurton, S Mohamadou, I Dillé, I Diallo, S Mamadou, E Adehossi, Y Hanki, O Tchousso, M Arzika, O Gazeré, F Amadou, N Illo, Y Abdourahmane, M Idé, Z Alhousseini, F Lamontagne, C Deze, E D'Ortenzio, S Diallo
In Niger, the tuberculosis (TB) screening among people living with human immunodeficiency virus (HIV) (PLHIV) is nonsystematic and the use of additional tests is very often limited. The objective of this research is to evaluate the performance and the cost-effectiveness of various paraclinical testing strategies of TB among adult patients with HIV, using available tests in routine for patients cared in Niamey. This is a multicentric prospective intervention study performed in Niamey between 2010 and 2013. TB screening has been sought in newly diagnosed PLHIV, before ART treatment, performing consistently: a sputum examination by MZN (Ziehl-Nielsen staining) and microscopy fluorescence (MIF), chest radiography (CR), and abdominal ultrasound...
November 15, 2016: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/27846469/a-nuclease-that-mediates-cell-death-induced-by-dna-damage-and-poly-adp-ribose-polymerase-1
#8
Yingfei Wang, Ran An, George K Umanah, Hyejin Park, Kalyani Nambiar, Stephen M Eacker, BongWoo Kim, Lei Bao, Maged M Harraz, Calvin Chang, Rong Chen, Jennifer E Wang, Tae-In Kam, Jun Seop Jeong, Zhi Xie, Stewart Neifert, Jiang Qian, Shaida A Andrabi, Seth Blackshaw, Heng Zhu, Hongjun Song, Guo-Li Ming, Valina L Dawson, Ted M Dawson
Inhibition or genetic deletion of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) is protective against toxic insults in many organ systems. The molecular mechanisms underlying PARP-1-dependent cell death involve release of mitochondrial apoptosis-inducing factor (AIF) and its translocation to the nucleus, which results in chromatinolysis. We identified macrophage migration inhibitory factor (MIF) as a PARP-1-dependent AIF-associated nuclease (PAAN). AIF was required for recruitment of MIF to the nucleus, where MIF cleaves genomic DNA into large fragments...
October 7, 2016: Science
https://www.readbyqxmd.com/read/27844180/association-of-genetic-polymorphisms-in-mif-with-breast-cancer-risk-in-chinese-women
#9
Shuai Lin, Meng Wang, Xinghan Liu, Wenge Zhu, Yan Guo, Zhiming Dai, Pengtao Yang, Tian Tian, Cong Dai, Yi Zheng, Chunyan Hu, Linyan Wei, Zhijun Dai
Macrophage migration inhibitory factor (MIF) has been reported to associate with increased cancer risk in several cancers. However, the role of MIF in breast cancer (BC) susceptibility remains unknown. For the first time, we conducted a case-control study to assess the potential association of three common MIF gene variants (rs755622, rs1803976, rs11548059) with BC susceptibility in Chinese women. Total 560 breast cancer patients and 583 age- and sex-matched healthy individuals were recruited from Northwest China, and the DNA was genotyped by Sequenom MassARRAY...
November 14, 2016: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/27833444/association-of-macrophage-migration-inhibitory-factor-promoter-polymorphism-173g-c-with-susceptibility-to-childhood-asthma
#10
Tarek Z El-Adly, Sally Kamal, Hala Selim, Shahira Botros
INTRODUCTION: Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays an important role in the pathogenesis of asthma. Polymorphisms associated with inflammatory diseases exist in the promoter region of MIF, which alter its expression. We aimed to study the association of MIF promoter polymorphism -173G/C with childhood asthma. MATERIAL AND METHODS: In this case-control study, we recruited 60 pediatric patients with bronchial asthma and 90 age- and sex-matched healthy controls...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27825106/macrophage-migration-inhibitory-factor-protects-from-nonmelanoma-epidermal-tumors-by-regulating-the-number-of-antigen-presenting-cells-in-skin
#11
Tania Brocks, Oleg Fedorchenko, Nicola Schliermann, Astrid Stein, Ute M Moll, Seth Seegobin, Manfred Dewor, Michael Hallek, Yvonne Marquardt, Katharina Fietkau, Ruth Heise, Sebastian Huth, Herbert Pfister, Juergen Bernhagen, Richard Bucala, Jens M Baron, Guenter Fingerle-Rowson
The response of the skin to harmful environmental agents is shaped decisively by the status of the immune system. Keratinocytes constitutively express and secrete the chemokine-like mediator, macrophage migration inhibitory factor (MIF), more strongly than dermal fibroblasts, thereby creating a MIF gradient in skin. By using global and epidermis-restricted Mif knockout mice (Mif(-/-) and K14-Cre(+/tg); Mif(fl/fl)), we found that MIF both recruits and maintains antigen-presenting cells in the dermis/epidermis...
October 19, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27813116/distinct-osteomimetic-response-of-androgen-dependent-and-independent-human-prostate-cancer-cells-to-mechanical-action-of-fluid-flow-prometastatic-implications
#12
Álvaro González, Cira García de Durango, Verónica Alonso, Beatriz Bravo, Arancha Rodríguez de Gortázar, Alan Wells, Jerónimo Forteza, Fernando Vidal-Vanaclocha
BACKGROUND AND METHODS: Prostate cancer frequently expresses an osteomimetic phenotype, but it is unclear how it is regulated and what biological and clinical implications it confers. Because mechanical forces physiologically regulate bone-remodeling activity in osteocytes, we hypothesized that mechanical action of fluid flow (MAFF) at the cancer microenvironment may similarly foster prostate cancer cell osteomimicry. RESULTS: We showed that in vitro MAFF on androgen-dependent (LNCap) and androgen-independent (PC3) prostate cancer cells remarkably increased OPG, VEGF, RunX2, PTH1R, and PTHrP gene expression in both cell lines irrespective of their androgen dependency...
November 3, 2016: Prostate
https://www.readbyqxmd.com/read/27811451/expressions-of-macrophage-migration-inhibitory-factor-in-patients-with-chronic-kidney-disease
#13
Y Liu, X Zhang, G Liu, J Huang, Y Pan, Z Hu
CONTEXT: Uremic cardiomyopathy is a risk factor of end-stage renal disease (ESRD) and is responsible for high mortality rates and increased left ventricular mass index (LVMI). Macrophage migration inhibitory factor (MIF) promotes inflammation and is an important factor in uremic cardiomyopathy. AIMS: The aim of this study is to investigate the effects of serum macrophage MIF on myocardial hypertrophy in ESRD patients and to examine the relation of this factor to clinical characteristics...
November 2016: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27796618/distinct-secretory-activity-and-clinical-impact-of-subcutaneous-abdominal-adipose-tissue-in-women-with-rheumatoid-arthritis-and-osteoarthritis
#14
Ewa Kontny, Agnieszka Zielińska, Urszula Skalska, Krystyna Księżopolska-Orłowska, Piotr Głuszko, Włodzimierz Maśliński
In the general population, low-grade inflammation of adipose tissue accompanies obesity and contributes to cardiovascular disease (CVD) development, but the implication of this tissue in rheumatic disease pathology is unclear. Therefore, we characterized the secretory activity of subcutaneous abdominal adipose tissue (SAAT) of females with rheumatoid arthritis (RA) and osteoarthritis (OA) and searched for its relationship with intensity of systemic inflammation, body composition and comorbidity. The secretion of classical adipokines (leptin, adiponectin), pro- and anti-inflammatory factors, i...
October 28, 2016: Inflammation
https://www.readbyqxmd.com/read/27793992/identification-of-iguratimod-as-an-inhibitor-of-macrophage-migration-inhibitory-factor-mif-with-steroid-sparing-potential
#15
Joshua Bloom, Christine Metz, Saisha Nalawade, Julian Casabar, Kai Fan Cheng, Mingzhu He, Barbara Sherry, Thomas Coleman, Thomas Forsthuber, Yousef Al-Abed
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been implicated in a broad range of inflammatory and oncologic diseases. MIF is unique among cytokines in terms of its release profile and inflammatory role, notably as an endogenous counter- regulator of the anti-inflammatory effects of glucocorticoids. In addition, it exhibits a catalytic tautomerase activity amenable to the design of high-affinity small molecule inhibitors. Although several classes of these compounds have been identified, biological characterization of these molecules remains a topic of active investigation...
October 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27791057/sulfur-and-lead-isotopic-evidence-of-relic-archean-sediments-in-the-pitcairn-mantle-plume
#16
Hélène Delavault, Catherine Chauvel, Emilie Thomassot, Colin W Devey, Baptiste Dazas
The isotopic diversity of oceanic island basalts (OIB) is usually attributed to the influence, in their sources, of ancient material recycled into the mantle, although the nature, age, and quantities of this material remain controversial. The unradiogenic Pb isotope signature of the enriched mantle I (EM I) source of basalts from, for example, Pitcairn or Walvis Ridge has been variously attributed to recycled pelagic sediments, lower continental crust, or recycled subcontinental lithosphere. Our study helps resolve this debate by showing that Pitcairn lavas contain sulfides whose sulfur isotopic compositions are affected by mass-independent fractionation (S-MIF down to Δ(33)S = -0...
October 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27790963/comparison-between-merthiolate-iodine-formalin-and-kato-katz-methods-for-the-diagnosis-of-human-helminth-infections-in-resource-limited-settings
#17
R N Incani, T Homan, E Pinelli, L Mughini-Gras, H Guevara, J Jesus
Diagnosis of intestinal parasites through examination of fresh faecal samples is hampered by its unpleasantness and the urgent need to detect all parasitic forms. In this paper, we compared the standard Kato-Katz (KK) technique with a traditional fixation method, the merthiolate-iodine-formalin (MIF) method. Two hundred and twenty-seven faecal samples from individuals living in a rural setting in Venezuela with high to moderate prevalences of Ascaris lumbricoides (Al), Trichuris trichiura (Tt) and hookworm infections were examined...
October 28, 2016: Journal of Helminthology
https://www.readbyqxmd.com/read/27788497/macrophage-migration-inhibitory-factor-a-potential-driver-and-biomarker-for-head-and-neck-squamous-cell-carcinoma
#18
REVIEW
Sha-Sha Wang, Xiao Cen, Xin-Hua Liang, Ya-Ling Tang
Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, has been showed to be associated with the immunopathogenesis of many diseases. Recent study demonstrated that MIF promoted tumorigenesis and tumor progression and played a critical role in various kinds of human cancer including head and neck squamous cell carcinoma(HNSCC). Hence, in this paper we retrospected the relationship between MIF and angiogenesis, epithelial-mesenchymal transition (EMT), inflammation, immune response, hypoxia microenvironment, and discussed whether it is a promising biomarker for diagnosis and supervisor of HNSCC...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27787379/elevated-plasma-migration-inhibitory-factor-in-hypertension-hyperlipidemia-patients-correlates-with-impaired-endothelial-function
#19
Boda Zhou, Chuan Ren, Lingyun Zu, Lemin Zheng, Lijun Guo, Wei Gao
Migration inhibitory factor (MIF) has been shown to be critical in the pathology of early artherosclerosis; this article aim to investigate the plasma levels of MIF in hypertension plus hyperlipidemia patients.A total of 39 hypertension plus hyperlipidemia patients without any previous treatment were enrolled (HTN-HLP). Twenty-five healthy subjects were enrolled as the healthy control group (HEALTHY). Plasma MIF was measured by ELISA; laboratory and clinical characteristics were analyzed. HUVECs were treated with pooled plasma from HTN-HLP and HEALTHY groups, and the protein levels of adhesion molecules VCAM-1 and ICAM-1 were determined by ELISA...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27783251/variations-in-the-isotopic-composition-of-stable-mercury-isotopes-in-typical-mangrove-plants-of-the-jiulong-estuary-se-china
#20
Lumin Sun, Bingyan Lu, Dongxing Yuan, Wenbo Hao, Ying Zheng
Variations in the composition of stable isotopes of mercury contained in tissues (root, stem, leaf, and hypocotyl or flower) of three typical mangrove plants (Kandelia candel, Aegiceras corniculata, and Bruguiera gymnorhiza), collected from the mangrove wetland of Jiulong estuary, SE China, were used to investigate the sources and transformation of mercury in the mangrove plants. Tissue samples from the plants were digested and mercury in the solution was pre-concentrated with purge-trap method and then analyzed by multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS)...
October 25, 2016: Environmental Science and Pollution Research International
keyword
keyword
80421
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"