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Bone narrow transplant

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https://www.readbyqxmd.com/read/27747649/soft-tissue-grafting-for-peri-implantitis-a-treatment-option-in-case-of-unsuitable-skeletal-basic-morphology-of-the-alveolar-bone-and-lack-of-keratinized-mucosa-a-retrospective-clinical-cohort-study
#1
Michael Stiller, Rainer Mengel, Sebastian Becher, Bernhard Brinkmann, Barbara Peleska, Esther Kluk
BACKGROUND: This retrospective study evaluated soft-tissue grafting as a surgical treatment option for peri-implantitis in case of unsuitable basic skeletal morphology of the alveolar bone and lack of keratinized mucosa. METHODS: Twenty-eight patients (21 females, 7 males, at a mean age 59.4 years) were included with a total of 54 implants. All implants showed peri-implantitis and attached keratinized buccal mucosa of ≤2 mm. A surgical procedure of soft-tissue grafting (STG) was made by inserting an inlay and inlay-onlay transplant...
December 2015: Int J Implant Dent
https://www.readbyqxmd.com/read/27266812/inhibition-of-vascular-endothelial-growth-factor-reduces-cardiac-allograft-vasculopathy
#2
Safia Chatur, Brian W-C Wong, Jon M Carthy, Bruce M McManus
BACKGROUND: Cardiac allograft vasculopathy (CAV) is a leading expression of chronic organ rejection at and beyond 1 year post-transplantation. Host bone marrow (BM)-derived cell migration to the allograft has been demonstrated in earlier work. Vascular endothelial growth factor (VEGF) is endogenously overexpressed within allografts. Graft neo-angiogenesis has been proposed as a mechanism by which VEGF may contribute to CAV. Herein we assess the therapeutic effect of inhibition of VEGF expression in CAV...
September 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/26934429/ultrasonography-for-diagnosis-of-alcoholic-cirrhosis-in-people-with-alcoholic-liver-disease
#3
REVIEW
Chavdar S Pavlov, Giovanni Casazza, Marianna Semenistaia, Dimitrinka Nikolova, Emmanuel Tsochatzis, Ekaterina Liusina, Vladimir T Ivashkin, Christian Gluud
BACKGROUND: Heavy alcohol consumption causes alcoholic liver disease and is a causal factor of many types of liver injuries and concomitant diseases. It is a true systemic disease that may damage the digestive tract, the nervous system, the heart and vascular system, the bone and skeletal muscle system, and the endocrine and immune system, and can lead to cancer. Liver damage in turn, can present as multiple alcoholic liver diseases, including fatty liver, steatohepatitis, fibrosis, alcoholic cirrhosis, and hepatocellular carcinoma, with presence or absence of hepatitis B or C virus infection...
March 2, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26930022/prevalence-of-radiographic-knee-osteoarthritis-after-anterior-cruciate-ligament-reconstruction-with-or-without-meniscectomy-an-evidence-based-practice-paper
#4
Jennifer S Ruano, Michael R Sitler, Jeffrey B Driban
: Reference: Claes S, Hermie L, Verdonk R, Bellemans J, Verdonk P. Is osteoarthritis an inevitable consequence of anterior cruciate ligament reconstruction? A meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2013;21(9):1967-1976. CLINICAL QUESTION:  What is the prevalence of radiographic knee osteoarthritis (OA) at a mean follow-up equal to or greater than 10 years after autologous anterior cruciate ligament (ACL) reconstruction, with or without meniscectomy? DATA SOURCES:  The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines were used to conduct this meta-analysis...
March 1, 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/26848224/chronic-graft-versus-host-disease-mimicking-psoriasis-in-a-patient-with-hemophagocytic-lymphohistiocytosis
#5
Sihyeok Jang, In Su Kim, Sang Woong Youn
Graft-versus-host disease (GVHD) is a common complication of bone marrow transplantation (BMT) that can be classified as acute or chronic. Chronic GVHD, which usually occurs more than 3 months after BMT, includes typical lichenoid or sclerodermatous lesions. Psoriasiform eruption is a rare clinical manifestation of chronic GVHD, and there have been no reports of psoriasiform chronic GVHD associated with hemophagocytic lymphohistiocytosis. A 33-year-old woman who was diagnosed with hemophagocytic lymphohistiocytosis 10 years ago visited our outpatient clinic with psoriasiform eruption over her entire body...
February 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/26660176/a-simple-liquid-chromatography-tandem-mass-spectrometry-method-for-quantitation-of-plasma-busulfan
#6
Shuang Deng, Michael Kiscoan, Clint Frazee, Susan Abdel-Rahman, Jignesh Dalal, Uttam Garg
Busulfan is an alkylating agent widely used in the ablation of bone marrow cells before hematopoietic stem cell transplant. Due to large intraindividual and interindividual variations, and narrow therapeutic window, therapeutic drug monitoring of busulfan is warranted. A quick and reliable HPLC-MS/MS method was developed for the assay of plasma busulfan. HPLC involved C18 column, and MS/MS was used in electrospray ionization (ESI) positive mode. Quantitation and identification of busulfan was made using various multiple reactions monitoring (MRMs)...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/26596315/hypercalcemia-pathophysiological-aspects
#7
I Žofková
The metabolic pathways that contribute to maintain serum calcium concentration in narrow physiological range include the bone remodeling process, intestinal absorption and renal tubule resorption. Dysbalance in these regulations may lead to hyper- or hypocalcemia. Hypercalcemia is a potentionally life-threatening and relatively common clinical problem, which is mostly associated with hyperparathyroidism and/or malignant diseases (90 %). Scarce causes of hypercalcemia involve renal failure, kidney transplantation, endocrinopathies, granulomatous diseases, and the long-term treatment with some pharmaceuticals (vitamin D, retinoic acid, lithium)...
2016: Physiological Research
https://www.readbyqxmd.com/read/26522199/oral-manifestations-of-osteopetrosis
#8
Ahsan Ullah, Namal Pervez, Shammas Raza Khan, Muhammad Ishfaq, Sehrish Liaqat
Osteopetrosis is a hereditary disorder of bone characterized by sclerosis of bone and decreased marrow spaces. Due to depressed marrow function, this disorder can cause anemia, hepatosplenomegaly, recurrent infections and osteomyelitis of jaw. Excessive bone deposition in skull base leads to narrowing of foramina and cranial nerve compression. Bone marrow transplantation is the only curative treatment. Other treatments, like interferon gamma, corticosteroids, parathormone and erythropoietin are also used for management...
October 2015: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/26389835/should-busulfan-therapeutic-range-be-narrowed-in-pediatrics-experience-from-a-large-cohort-of-hematopoietic-stem-cell-transplant-children
#9
MULTICENTER STUDY
M Philippe, S Goutelle, J Guitton, X Fonrose, C Bergeron, P Girard, Y Bertrand, N Bleyzac
Busulfan, the corner stone of hematopoietic stem cell transplantation regimens, has a narrow therapeutic window. Therapeutic drug monitoring (TDM)-guided dosing to reach the conventional area under the concentration-time curve (AUC) target range of 900-1500 μmol min/L is associated with better outcomes. We report our experience with busulfan TDM in a large cohort of children. The aims were to investigate the relevance of using a more restricted therapeutic range and investigate the association between busulfan therapeutic range and clinical outcome...
January 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/26346289/voriconazole-induced-periostitis-post-transplant-an-illustrative-review-of-thoracic-computed-tomography-imaging-manifestations
#10
M Rheinboldt, Z Delproposto, R Agarwal
Voriconazole, first commercially approved in 2002 as a second-generation antifungal agent, is commonly used in the immunocompromised setting as both a therapeutic and prophylactic agent. Since 2009, scattered case reports and small case series have detailed a secondary drug-related hyperfluorosis-induced painful periostitis that can occur in the treated patient population. We present a pictorial review of the thoracic imaging manifestations utilizing 3 illustrative cases in the setting of both solid organ and bone marrow transplantation...
December 2015: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/26325507/high-throughput-sequencing-analysis-of-the-immunoglobulin-heavy-chain-gene-from-flow-sorted-b-cell-sub-populations-define-the-dynamics-of-follicular-lymphoma-clonal-evolution
#11
Emanuela Carlotti, David Wrench, Guglielmo Rosignoli, Jacek Marzec, Ajanthah Sangaralingam, Lena Hazanov, Miri Michaeli, Simon Hallam, Tracy Chaplin, Sameena Iqbal, Maria Calaminici, Bryan Young, Ramit Mehr, Peter Campbell, Jude Fitzgibbon, John G Gribben
Understanding the dynamics of evolution of Follicular Lymphoma (FL) clones during disease progression is important for monitoring and targeting this tumor effectively. Genetic profiling of serial FL biopsies and examples of FL transmission following bone marrow transplant suggest that this disease may evolve by divergent evolution from a common ancestor cell. However where this ancestor cell resides and how it evolves is still unclear. The analysis of the pattern of somatic hypermutation of the immunoglobulin gene (Ig) is traditionally used for tracking the physiological clonal evolution of B cells within the germinal center and allows to discriminate those cells that have just entered the germinal center and display features of ancestor cells from those B cells that keep re-circulating across different lymphoid organs...
2015: PloS One
https://www.readbyqxmd.com/read/26096962/g-csf-contributes-at-the-healing-of-tunica-media-of-arteriotomy-injured-rat-carotids-by-promoting-differentiation-of-vascular-smooth-muscle-cells
#12
Barbara Rinaldi, Mauro Finicelli, Maria Donniacuo, Giovanni Di Bernardo, Giulia Gritti, Stefania Del Gaudio, Amalia Forte, Gianfranco Peluso, Marilena Cipollaro, Francesco Rossi, Umberto Galderisi
Restenosis is a complex pathophysiological disease whose causative mechanisms are not fully understood. Previous studies allowed us to demonstrate the efficacy of bone marrow mesenchymal stromal cells (MSCs) transplantation in limiting the pathophysiological remodeling in a model of arteriotomy-induced (re) stenosis. In the current research we studied the effectiveness of G-CSF treatment on male rate rats that were subjected carotid arteriotomy in order to evaluate a potentially effective non-invasive strategy that recapitulates the MSC-mediated recovery of injured vessels...
January 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/26044171/-the-gingivo-periosto-plastic-surgery-with-osseous-substitute-technique-and-first-results
#13
S Adam, H D Sama, N Dégardin, A Gallucci, V Bellot-Samson, J Bardot
INTRODUCTION: Ortho dontico-surgical coverage of alveolar crack is essential in reason of its repercussions on facial growth and implementation of children's teeth set. We proposed to realize a premature gingivo periosto plastic surgery from 4 years old by osseous substitute to lower age of alveolar cracks closure and decrease the morbidity of patients. PATIENTS AND METHODS: We conducted a retrospective study over one year (January, 2012 to December, 2012), with six months postoperatively outcomes, on 23 cases of gingivo periosto plastic sugary with osseous substitute type glass by bone transplant at infantile plastic surgery service of Timone - Children teaching hospital of Marseille, France...
August 2016: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/25989498/clinicopathological-findings-of-chronic-rejection-in-a-face-grafted-patient
#14
Palmina Petruzzo, Jean Kanitakis, Sylvie Testelin, Jean-Baptiste Pialat, Fanny Buron, Lionel Badet, Olivier Thaunat, Bernard Devauchelle, Emmanuel Morelon
BACKGROUND: Skin chronic rejection (CR) in vascularized composite allotransplantation has not been included in the Banff classification yet. We report a face-transplant patient who developed cutaneous clinicopathologic changes suggestive of CR. METHODS: The recipient was a 27-year-old man with severe disfigurement of the lower face due to a pyrotechnic explosion. He received a facial allograft, including mandible, cheeks, lips, and chin, in November 2009. Immunosuppression included antithymocyte globulins and bone-marrow infusion then steroids, tacrolimus, and mycophenolate mofetil...
December 2015: Transplantation
https://www.readbyqxmd.com/read/25952602/-therapeutic-potential-of-bone-marrow-stem-cells-in-cerebral-infarction
#15
REVIEW
Gilberto Sánchez-Cruz, Lismary Milián-Rodríguez
INTRODUCTION: Stem cells are an alternative therapy for cerebral infarction that is still in the experimental phase. AIMS: To report on the existing scientific evidence on the therapeutic potential of bone marrow stem cells in this disease. DEVELOPMENT: Cerebral infarction accounts for 80% of cerebrovascular diseases. Thrombolysis is the only approved therapy, but, owing to its narrow therapeutic window, it is only applied to a low percentage of patients...
May 16, 2015: Revista de Neurologia
https://www.readbyqxmd.com/read/25881738/lung-transplantation-and-extracorporeal-photopheresis-the-answer-to-bronchiolitis-obliterans
#16
REVIEW
Gordon L Yung, Vanessa Craig
Bronchiolitis obliterans (BO) is a rare condition characterized by narrowing of small airways. Although it can be caused by variety of conditions, most cases occur after lung and bone marrow transplantation in the form of graft-versus-host-disease and chronic rejection, respectively. Extracorporeal photopheresis (ECP) has emerged as a promising treatment for the condition, especially for BO after lung transplantation. Available data suggest that around two-thirds of patients may demonstrate either slowing or cessation of disease progression after treatment with ECP...
April 2015: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/25711909/a-novel-therapy-strategy-for-bile-duct-repair-using-tissue-engineering-technique-pcl-plga-bilayered-scaffold-with-hmscs
#17
Chen Zong, Meicong Wang, Fuchun Yang, Guojun Chen, Jiarong Chen, Zihua Tang, Quanwen Liu, Changyou Gao, Lie Ma, Jinfu Wang
The current clinical treatments for complications caused by hepatobiliary surgery still have some inevitable weakness. The aim of the study was to fabricate a tissue-engineered bile duct that utilized a novel bilayered polymer scaffold combined with human bone marrow-derived mesenchymal stem cells (hMSCs) for new treatment of biliary disease. The biocompatibility of polycaprolactone (PCL) (PCL)/poly(lactide-co-glycolide) (PLGA) scaffold with hMSCs was first examined, and the hMSC-PCL/PLGA constructs (MPPCs) prepared...
February 25, 2015: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/25542796/the-effect-of-transplantation-of-nasal-mucosal-epithelial-cell-sheets-after-middle-ear-surgery-in-a-rabbit-model
#18
Kazuhisa Yamamoto, Takanori Hama, Masayuki Yamato, Hirotaka Uchimizu, Hiroaki Sugiyama, Ryo Takagi, Yuichiro Yaguchi, Teruo Okano, Hiromi Kojima
Postoperative regeneration of the middle ear mucosa and pneumatization of the middle ear cavity are of great importance after middle ear surgery. This study developed a new method to transplant autologous nasal mucosal epithelial cell sheets into the damaged middle ear cavity. The aim of this study was to evaluate postoperative healing after the transplantation of the cell sheets. Rabbit nasal mucosal epithelial cell sheets were fabricated on a temperature-responsive culture dish, and transplanted into the damaged middle ear of rabbit, which was surgically created...
February 2015: Biomaterials
https://www.readbyqxmd.com/read/25400548/stem-cell-based-treatments-against-stroke-observations-from-human-proof-of-concept-studies-and-considerations-regarding-clinical-applicability
#19
REVIEW
Thorsten R Doeppner, Dirk M Hermann
Ischemic stroke remains a heavy burden for industrialized countries. The only causal therapy is the recanalization of occluded vessels via thrombolysis, which due to a narrow time window still can be offered only to a minority of patients. Since the majority of patients continues to exhibit neurological deficits even following successful thrombolysis, restorative therapies are urgently needed that promote brain remodeling and repair once stroke injury has occurred. Due to their unique properties of action, stem cell-based strategies gained increasing interest during recent years...
2014: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/25389006/mesenchymal-stem-cells-alleviate-atherosclerosis-by-elevating-number-and-function-of-cd4-cd25-foxp3-regulatory-t-cells-and-inhibiting-macrophage-foam-cell-formation
#20
Zhi Xiao Wang, Chong Quan Wang, Xiao Yan Li, Gao Ke Feng, Hong Ling Zhu, Yan Ding, Xue Jun Jiang
Atherosclerosis is a chronic inflammatory disease characterized by the formation of plaques inside arteries, leading to narrowing and blockage. Potential therapeutic strategies include expanding the population of regulatory T-cells (Tregs) to enhance atheroprotective immunity, and inhibiting the formation of macrophage foam cells. Here, we studied the effect of bone marrow-derived mesenchymal stem cells (BM-MSCs) on atherosclerotic plaque formation in Apolipoprotein E(-/-) (ApoE-KO) mice, and elucidated the underlying mechanism...
February 2015: Molecular and Cellular Biochemistry
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