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https://www.readbyqxmd.com/read/29165342/knee-and-ankle-arthroplasty-in-hemophilia
#1
REVIEW
Luigi Piero Solimeno, Gianluigi Pasta
Today, major surgical procedures can be safely performed in hemophilic patients with chronic arthropathy, using available factor concentrates. In this setting, total knee replacement is considered the "gold standard", while the use of total ankle replacement is still debated. Indeed, the unsatisfactory results obtained with the previous available design of implants did not raise enthusiasm as knee or hip replacement. Recently, the introduction of new implant designs and better reported outcomes have renewed the interest in total ankle replacement in people with hemophilia...
November 22, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29164814/a-thrombin-receptor-derived-imaging-agent-detects-subclinical-arthritis-in-mice
#2
Beth Friedman, Michael A Whitney, Elamprakash N Savariar, Christa Caneda, Paul Steinbach, Qing Xiong, Dina V Hingorani, Jessica Crisp, Stephen R Adams, Michael Kenner, Csilla N Lippert, Quyen T Nguyen, Monica Guma, Roger Y Tsien, Maripat Corr
OBJECTIVE: Functional imaging of synovitis could improve both early detection of rheumatoid arthritis (RA) and long-term outcomes. Motivated by the intersection of inflammation with coagulation protease activation, we examine coagulation protease activities in arthritic mice with a dual fluorescent Ratiometric thrombin-Activatable Cell Penetrating Peptide (RACPPNleTPRSFL ). METHOD: Mice with chronic transgenic K/BxN arthritis, or with arthritis on Day 1 of passive serum transfer induced arthritis (STIA), were imaged in vivo for Cy5 em: Cy7 em ratiometric fluorescence from proteolytic cleavage and activation of RACPPNleTPRSFL ...
November 22, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29164719/circadian-variation-of-flexor-withdrawal-and-crossed-extensor-reflexes-in-patients-with-restless-legs-syndrome
#3
Chloe Dafkin, Andrew Green, Benita Olivier, Warrick Mckinon, Samantha Kerr
An evening state of spinal hyperexcitability has been proposed to be a possible cause of evening increases in restless legs syndrome symptoms. Thus, the objective of the current study was to assess the circadian variation in spinal excitability in patients with restless legs syndrome based on flexor withdrawal reflex and crossed extensor reflex responses. The reflexes were elicited on 12 participants with restless legs syndrome and 12 healthy control participants in the evening (PM) and the morning (AM). Reflex response magnitudes were measured electromyographically and kinematically...
November 22, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/29164530/ultrasound-guided-lateral-medial-transmuscular-quadratus-lumborum-block-for-analgesia-following-anterior-iliac-crest-bone-graft-harvesting-a-clinical-and-anatomical-study
#4
Rakesh V Sondekoppam, Vivian Ip, David F Johnston, Vishal Uppal, Marjorie Johnson, Sugantha Ganapathy, Ban C H Tsui
BACKGROUND: The anterior iliac crest (AIC) is one of the most common sites for harvesting autologous bone, but the associated postoperative pain can result in significant morbidity. Recently, the transmuscular quadratus lumborum block (TQL) has been described to anesthetize the thoraco-lumbar nerves. This study utilizes a combination of cadaveric models and clinical case studies to evaluate the dermatomal coverage and analgesic utility of TQL for AIC bone graft donor site analgesia. METHODS: Ten ultrasound-guided TQL injections were performed in five cadaver specimens using a lateral-to-medial transmuscular approach...
November 21, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29164285/referent-control-of-the-orientation-of-posture-and-movement-in-the-gravitational-field
#5
Aditi A Mullick, Nicolas A Turpin, Szu-Chen Hsu, Sandeep K Subramanian, Anatol G Feldman, Mindy F Levin
This study addresses the question of how posture and movement are oriented with respect to the direction of gravity. It is suggested that neural control levels coordinate spatial thresholds at which multiple muscles begin to be activated to specify a referent body orientation (RO) at which muscle activity is minimized. Under the influence of gravity, the body is deflected from the RO to an actual orientation (AO) until the emerging muscle activity and forces begin to balance gravitational forces and maintain body stability...
November 21, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29164109/identification-of-directed-interactions-in-kinematic-data-during-running
#6
Giovana Y Nakashima, Theresa H Nakagawa, Ana F Dos Santos, Fábio V Serrão, Michel Bessani, Carlos D Maciel
The knowledge of motion dynamics during running activity is crucial to enhance the development of rehabilitation techniques and injury prevention programs. Recent studies investigated the interaction between joints, using several analysis techniques, as cross-correlation, sensitivity analysis, among others. However, the direction of the joints pairing is still not understood. This paper proposes a study of the influence direction pattern in healthy runners by using kinematic data together with partial directed coherence, a frequency approach of Granger causality...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29163992/cd56-negative-aggressive-nk-cell-leukemia-relapsing-as-multiple-cranial-nerve-palsies-case-report-and-literature-review
#7
M Guerreiro, F Príncipe, M J Teles, S Fonseca, A H Santos, E Fonseca, P Gomes, C Marques, M Lima
Background: Aggressive natural killer cell leukemia (ANKL) is extremely rare and habitually manifests as a systemic disease with multiorgan failure that rapidly evolves to death. The neoplastic natural killer (NK) cells usually harbor the Epstein-Barr virus (EBV) with a latent viral infection pattern type II; they often have a cytoplasmic CD3ε(+) and surface CD3(-), CD2(+), and CD56(+) immunophenotype, and they show complex genetic abnormalities affecting multiple tumor suppressor genes and oncogenes...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/29163948/the-heart-matters-in-diabetes-10-year-outcomes-of-peripheral-artery-disease
#8
Thomas Mueller, Franz Hinterreiter, Werner Poelz, Meinhard Haltmayer, Benjamin Dieplinger
Objectives: Mortality rates at 10 years are higher in diabetic patients with chronic lower extremity peripheral arterial disease than in non-diabetic peripheral arterial disease patients. We tested the hypothesis that the predictors of mortality differ between diabetic and non-diabetic peripheral arterial disease patients. Methods: We studied 331 consecutive patients who were <75 years of age, symptomatic for peripheral arterial disease, and admitted to a tertiary care hospital...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/29163340/the-dominant-subthalamic-nucleus-phenomenon-in-bilateral-deep-brain-stimulation-for-parkinson-s-disease-evidence-from-a-gait-analysis-study
#9
Mario Giorgio Rizzone, Maurizio Ferrarin, Michele Maria Lanotte, Leonardo Lopiano, Ilaria Carpinella
Background: It has been suggested that parkinsonian [Parkinson's disease (PD)] patients might have a "dominant" (DOM) subthalamic nucleus (STN), whose unilateral electrical stimulation [deep brain stimulation (DBS)] could lead to an improvement in PD symptoms similar to bilateral STN-DBS. Objectives: Since disability in PD patients is often related to gait problems, in this study, we wanted to investigate in a group of patients bilaterally implanted for STN-DBS: (1) if it was possible to identify a subgroup of subjects with a dominant STN; (2) in the case, if the unilateral stimulation of the dominant STN was capable to improve gait abnormalities, as assessed by instrumented multifactorial gait analysis, similarly to what observed with bilateral stimulation...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29163196/an-inertial-sensor-based-method-for-estimating-the-athlete-s-relative-joint-center-positions-and-center-of-mass-kinematics-in-alpine-ski-racing
#10
Benedikt Fasel, Jörg Spörri, Pascal Schütz, Silvio Lorenzetti, Kamiar Aminian
For the purpose of gaining a deeper understanding of the relationship between external training load and health in competitive alpine skiing, an accurate and precise estimation of the athlete's kinematics is an essential methodological prerequisite. This study proposes an inertial sensor-based method to estimate the athlete's relative joint center positions and center of mass (CoM) kinematics in alpine skiing. Eleven inertial sensors were fixed to the lower and upper limbs, trunk, and head. The relative positions of the ankle, knee, hip, shoulder, elbow, and wrist joint centers, as well as the athlete's CoM kinematics were validated against a marker-based optoelectronic motion capture system during indoor carpet skiing...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162381/strategies-adopted-by-younger-and-older-adults-while-operating-a-non-pedal-tricycle
#11
Tatiane Calve, Douglas Vicente Russo Júnior, Ana Maria Forti Barela
BACKGROUND: Exercises that could prevent gait impairment of older adults should be implemented in such a way that practitioners can keep motivation and adherence independent of older adults fitness levels. OBJECTIVE: This study describes how younger and older adults use a non-pedal tricycle to transport their bodies along a pathway. METHODS: Nine younger (24±4.9y) and nine older (66±4.0y) adults participated in this study. They moved along a straight pathway at a self-selected comfortable speed with reflective markers on their main lower limb landmarks...
November 8, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/29162367/arterial-reconstructions-for-chronic-lower-extremity-ischemia-in-preadolescent-and-adolescent-children
#12
Jonathan L Eliason, Dawn M Coleman, Adam Gumushian, James C Stanley
OBJECTIVE: Chronic lower extremity ischemia in pediatric patients is uncommon. The intent of this study was to better define the arterial reconstructive options and their long-term durability in preadolescent and adolescent children having clinically relevant arterial occlusions affecting the lower extremity. METHODS: The medical records of 33 consecutive pediatric patients who underwent lower extremity revascularization for chronic ischemia at the University of Michigan from 1974 to 2016 were reviewed...
November 18, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29162365/ankle-fracture-controversies-do-the-foot-and-ankle-specialists-have-a-different-vision
#13
G González-Lucena, D Pérez-Prieto, A López-Alcover, A Ginés-Cespedosa
OBJECTIVE: To analyse the differences in the management of ankle fractures between orthopaedic/trauma surgeons and foot and ankle specialists. MATERIAL AND METHOD: An e-mail survey was performed asking some of the country's orthopaedic surgeons controversial questions regarding the analysis of 5 clinical cases of different ankle fractures. RESULTS: Seventy-two surgeons responded to the questionnaire (response rate of 24.2%): 37 foot and ankle specialists and 35 non-specialist orthopaedic surgeons...
November 18, 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29162249/functional-outcome-after-calcaneus-fractures-a-comparison-between-polytrauma-patients-and-isolated-fractures
#14
Pablo Renovell-Ferrer, Xavier Bertó-Martí, José Diranzo-García, Luis Barrera-Puigdorells, Vicente Estrems-Díaz, Antonio Silvestre-Muñoz, Antonio Brú-Pomer
BACKGROUND: Displaced intra-articular calcaneal fractures (DIACFs) can have long-term consequences in terms of foot pain and disability. This injury frequently occurs in the context of polytrauma patients and its influence in long-term functional prognosis is well known. The purpose of this study is to compare the etiology, severity, and functional outcome of the operated DIACFs between polytrauma patients and isolated cases. METHODS: Eighty-six patients with operated displaced intra-articular calcaneal fractures through open reduction and internal fixation (ORIF) were managed at our institution between January 1, 2008 and December 31, 2015...
November 2017: Injury
https://www.readbyqxmd.com/read/29162248/predicting-syndesmotic-injuries-in-ankle-fractures-a-new-system-based-on-the-medial-malleolar-focus
#15
Enrique Sánchez-Morata, José Carlos Martínez-Ávila, Elena Vacas Sánchez, Verónica Jiménez Díaz, Jaime Zorrilla Sánchez de Neyra, Jesús Vilá Y Rico
The early establishment of the diagnosis of a syndesmotic injury is essential for treatment selection. However, such injuries may not be apparent radiographically. Previous studies have attempted to describe correlations between medial malleolar fracture geometry and syndesmotic disruption. The main objective of this study was to create predictive models for assessing syndesmotic injuries based on an originally described angle, i.e., the medial crural-focal angle (MCFA). This study included 138 ankle fractures involving the medial malleolus...
November 2017: Injury
https://www.readbyqxmd.com/read/29162244/locking-versus-non-locking-one-third-tubular-plates-for-treating-osteoporotic-distal-fibula-fractures-a-comparative-study
#16
Mario Herrera-Pérez, Maria J Gutiérrez-Morales, Ayron Guerra-Ferraz, Jose L Pais-Brito, Juan Boluda-Mengod, Gerardo L Garcés
INTRODUCTION: Ankle fractures represent the third most common fracture in elderly patients, after hip and wrist fractures. Distal fibula fractures in this population are closely related to osteoporosis, which renders commonly used methods of internal fixation technically demanding and prone to failure. Currently there is a tendency to fix osteoporotic metaphyseal and epiphyseal fractures with locking plates. However, published accounts about the use of this technology in osteoporotic distal fibula fractures are scarce...
November 2017: Injury
https://www.readbyqxmd.com/read/29162077/subtalar-instability-imaging-features-of-subtalar-ligaments-on-3d-isotropic-ankle-mri
#17
Tae Hyung Kim, Sung Gyu Moon, Hong-Geun Jung, Na Ra Kim
BACKGROUND: MRI analysis of subtalar ligaments in the tarsal sinus has not been well performed. We retrospectively investigated the appearance of subtalar ligaments using 3D isotropic MRI and compared imaging findings of subtalar ligaments between patients with subtalar instability (STI) and controls. METHODS: Preoperative MRIs of 23 STI patients treated with arthroscopic subtalar reconstruction were compared to MRIs of 23 age- and sex-matched control subjects without STI...
November 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29161930/no-radiological-and-clinical-advantages-with-patient-specific-positioning-guides-in-total-knee-replacement
#18
Justin A M J Van Leeuwen, Finnur Snorrason, Stephan M Röhrl
Background and purpose - Although the use of patient-specific positioning guides (PSPGs) in total knee replacement (TKR) in theory is promising, the technique has not yet proven its superior- ity compared with the conventional method. We compared radio- logical alignment and clinical outcome between TKR performed with the use of PSPGs and the conventional operation method. Patients and methods - 3 hospitals participated in a prospec- tive trial. 109 patients were randomized to either the conventional method or to the use of PSPGs...
November 22, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/29161626/the-effect-of-augmented-somatosensory-feedback-on-standing-postural-sway
#19
Angela Smalley, Scott C White, Robert Burkard
Impaired balance resulting from reduced postural control occurs with aging and various medical conditions. Sensory input for balance control is provided by the visual, vestibular and somatosensory systems. Previous research suggests that increased proprioceptive feedback from various lower extremity devices improves balance. Mixed results have been reported with the use of orthoses such as ankle foot orthoses (AFOs). In this study, 20 healthy subjects wore footplates in their shoes or straps around their lower legs in order to imitate the somatosensory feedback produced by wearing AFOs, but without providing ankle restriction...
November 14, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29161138/autologous-matrix-induced-chondrogenesis-a-systematic-review-of-the-clinical-evidence
#20
Liang Gao, Patrick Orth, Magali Cucchiarini, Henning Madry
BACKGROUND: The addition of a type I/III collagen membrane in cartilage defects treated with microfracture has been advocated for cartilage repair, termed "autologous matrix-induced chondrogenesis" (AMIC). PURPOSE: To examine the current clinical evidence regarding AMIC for focal chondral defects. STUDY DESIGN: Systematic review. METHODS: A systematic review was performed by searching PubMed, ScienceDirect, and Cochrane Library databases...
November 1, 2017: American Journal of Sports Medicine
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