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14-3-3 in RA diagnosis

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https://www.readbyqxmd.com/read/27846761/prognostic-factors-of-methotrexate-associated-lymphoproliferative-disorders-associated-with-rheumatoid-arthritis-and-plausible-application-of-biological-agents
#1
Takayuki Katsuyama, Ken-Ei Sada, Minglu Yan, Sonia Zeggar, Sumie Hiramatsu, Yoshia Miyawaki, Keiji Ohashi, Michiko Morishita, Haruki Watanabe, Eri Katsuyama, Mariko Takano-Narazaki, Noriko Toyota-Tatebe, Katsue Sunahori-Watanabe, Tomoko Kawabata, Kohei Miyake, Toru Kiguchi, Jun Wada
OBJECTIVES: To determine prognostic factors of methotrexate-associated lymphoproliferative disorder (MTX-LPD) and evaluate the efficacy and safety of biological therapy in rheumatoid arthritis (RA) complicated with MTX-LPD. METHODS: Thirty RA patients who developed MTX-LPD were investigated in this study. We compared the clinical and laboratory parameters of patients who achieved regression of LPD by MTX withdrawal with those who required chemotherapy and evaluated the clinical course of RA after LPD development...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27802328/is-time-to-reach-edss-6-0-faster-in-patients-with-late-onset-versus-young-onset-multiple-sclerosis
#2
Raed Alroughani, Saeed Akhtar, Samar Ahmed, Raed Behbehani, Jasem Al-Hashel
BACKGROUND & OBJECTIVES: Published natural history data on late-onset of multiple sclerosis are limited. We aimed to assess the risk of attaining EDSS 6.0 among patients with late-onset (> 40 years) MS (LOMS) and young-onset (18-40 years) MS (YOMS). METHODS: This cross-sectional cohort study was conducted to identify LOMS and YOMS patients' with relapsing remitting course at MS diagnosis. Time (years) to reach sustained EDSS 6.0 was compared between LOMS and AOMS patients...
2016: PloS One
https://www.readbyqxmd.com/read/27788297/progressive-decline-of-lung-function-in-rheumatoid-arthritis-associated-interstitial-lung-disease
#3
Jorge A Zamora-Legoff, Megan L Krause, Cynthia S Crowson, Jay H Ryu, Eric L Matteson
OBJECTIVE: Interstitial lung disease (ILD) is associated with substantial morbidity in rheumatoid arthritis (RA), but very little is known about its long-term progression. METHODS: All patients with RA-ILD seen at Mayo Clinic in 1998-2014 with at least 4 weeks follow-up and at least 1 pulmonary function test (PFT) were identified and manually screened for study inclusion. Progression was defined as a diffusing capacity for carbon monoxide (DLCO) <40% predicted or too ill to perform, or a forced vital capacity (FVC) <50% predicted...
October 27, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27753918/os-04-02-high-prevalence-of-multisite-fibromuscular-dysplasia-the-arcadia-registry
#4
Pierre-Francois Plouin
OBJECTIVE: ARCADIA (Assessment of Renal and Cervical Artery DysplasIA) is a registry designed to assess in adults with fibromuscular dysplasia (FMD) the distribution of arterial lesions and the frequency of FMD affecting at least two vascular beds (multisite FMD). DESIGN AND METHOD: Patients were eligible if they had non-atherosclerotic, non-inflammatory and non-syndromic stenosing lesions affecting renal (RA) and/or cervico-encephalic (CEA) arteries and gave informed consent to undergo skull to pelvis angiographic imaging using CT-, MR-, or digital subtraction-angiography...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27747534/delays-in-initiation-of-disease-modifying-therapy-in-rheumatoid-arthritis-patients-data-from-a-us-based-registry
#5
Dimitrios A Pappas, Jeffrey D Kent, Jeffrey D Greenberg, Marc A Mason, Joel M Kremer, Robert J Holt
INTRODUCTION: The goal of this study was to evaluate how frequently rheumatoid arthritis (RA) therapy is instituted promptly and to describe the characteristics of patients who are not treated early upon diagnosis. METHODS: The percentage of patients who at the time of enrollment in the Corrona registry were not receiving any RA-directed therapy was evaluated and their characteristics were summarized. The time to subsequent initiation of any RA-directed therapy was also estimated...
December 2015: Rheumatology and Therapy
https://www.readbyqxmd.com/read/27643303/os-04-02-high-prevalence-of-multisite-fibromuscular-dysplasia-the-arcadia-registry
#6
Pierre-Francois Plouin
OBJECTIVE: ARCADIA (Assessment of Renal and Cervical Artery DysplasIA) is a registry designed to assess in adults with fibromuscular dysplasia (FMD) the distribution of arterial lesions and the frequency of FMD affecting at least two vascular beds (multisite FMD). DESIGN AND METHOD: Patients were eligible if they had non-atherosclerotic, non-inflammatory and non-syndromic stenosing lesions affecting renal (RA) and/or cervico-encephalic (CEA) arteries and gave informed consent to undergo skull to pelvis angiographic imaging using CT-, MR-, or digital subtraction-angiography...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27501914/depression-risk-in-patients-with-late-onset-rheumatoid-arthritis-in-germany
#7
Julia Drosselmeyer, Louis Jacob, Wolfgang Rathmann, Michael A Rapp, Karel Kostev
GOAL: The goal of this study was to determine the prevalence of depression and its risk factors in patients with late-onset rheumatoid arthritis (RA) treated in German primary care practices. METHODS: Longitudinal data from general practices (n=1072) throughout Germany were analyzed. Individuals initially diagnosed with RA (2009-2013) were identified, and 7301 patients were included and matched (1:1) to 7301 controls. The primary outcome measure was the initial diagnosis of depression within 5 years after the index date in patients with and without RA...
August 8, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27476621/overlap-between-systemic-sclerosis-and-rheumatoid-arthritis-a-distinct-clinical-entity
#8
Alex Magno Coelho Horimoto, Izaias Pereira da Costa
INTRODUCTION: Systemic sclerosis (SSc) is an autoimmune disease of the connective tissue characterized by the triad of vascular injury, autoimmunity (cellular and humoral) and tissue fibrosis. It is estimated that musculoskeletal pain is a common complaint of patients with SSc, ranging from 40 to 80%, and mainly in patients with early diffuse disease. Arthritis, clinically observed, may be a feature seen in the presentation of SSc, often leading to early diagnostic errors with rheumatoid arthritis (RA)...
July 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27469920/value-of-high-frequency-ultrasound-in-the-diagnosis-of-peripheral-nerve-compression-in-rheumatoid-arthritis-patients
#9
(no author information available yet)
<strong>Objective </strong>To evaluate the value of high-frequency ultrasound (HFUS) in diagnosing peripheral nerve compression in patients with rheumatoid arthritis (RA). <strong>Methods </strong>The upper limb nerves were evaluated by HFUS in 80 RA patients (RA group) and 60 non-RA patients (control group),then the incidence of peripheral nerve compression was recorded respectively. RA patients with/without neurological symptoms were compared in terms of age,disease course,Health Assessment Questionnaire Disability Index (HAQ-DI) score,and clinical disease activity index (CDAI)...
June 10, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27448151/risk-of-serious-infection-in-patients-with-rheumatoid-arthritis-associated-interstitial-lung-disease
#10
Jorge A Zamora-Legoff, Megan L Krause, Cynthia S Crowson, Jay H Ryu, Eric L Matteson
The objective of this study is to assess the occurrence of and risk factors for serious infections in rheumatoid arthritis (RA)-associated interstitial lung disease (ILD). All patients with RA-ILD (ACR 1987 criteria for RA) seen at a single center from 1998 to 2014 were identified and manually screened for study inclusion. Follow-up data were abstracted until death or December 31, 2015. Serious infection was defined as requiring antimicrobial therapy and hospitalization. Risk of infection was analyzed by person-year (py) methods using time-dependent covariates started when the medication was first used and stopped 30 days after the medication was discontinued...
October 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27431503/hospitalization-for-musculoskeletal-disorders-in-rheumatoid-arthritis-patients-a-population-based-study
#11
Marina Amaral de Ávila Machado, Sasha Bernatsky, Louis Bessette, Hacene Nedjar, Elham Rahme
BACKGROUND: Rheumatoid arthritis (RA) patients failing disease modifying antirheumatic drugs (DMARDs) may undergo anti-Tumor Necrosis Factor (anti-TNF) therapy. Using the Quebec health services administrative databases, we examined the rates of musculoskeletal (MSD)-related hospitalizations among RA patients receiving anti-TNF, DMARDs, and neither of those therapies (non-users). METHODS: Matched cohort analyses were performed separately in 2002-2006 and 2007-2011...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27294646/epidemiology-of-rheumatoid-arthritis-ra-in-rural-and-urban-areas-of-poland-2008-2012
#12
Petre Iltchev, Andrzej Śliwczyński, Tomasz Czeleko, Aleksandra Sierocka, Małgorzata Tłustochowicz, Witold Tłustochowicz, Dariusz Timler, Melania Brzozowska, Franciszek Szatko, Michał Marczak
OBJECTIVE: The aim of this study is to investigate the morbidity rate due to Rheumatoid Arthritis (RA) in the Polish population during 2008-2012, calculated per 1,000 inhabitants, and taking into account the differences between provincess, area of residence (urban or rural) and gender. MATERIALS AND METHOD: From the NFZ IT systems, PESEL number information was obtained for all 17 types of services contracted in 2008-2012, for patients whose main diagnosis in the report was the ICD-10 disease code: M05...
June 2, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/27175294/when-rheumatologists-report-that-they-agree-with-a-guideline-does-this-mean-that-they-practise-the-guideline-in-clinical-practice-results-of-the-international-recommendation-implementation-study-iris
#13
Emilia Gvozdenović, Cornelia F Allaart, Désirée van der Heijde, Gianfranco Ferraccioli, Josef S Smolen, Tom W J Huizinga, Robert Landewé
INTRODUCTION: The European League Against Rheumatism (EULAR) recommendations for the management of rheumatoid arthritis (RA) and the treat-to-target (T2T) principles have been developed in order to improve the treatment outcome of patients with RA, and have received broad attention. It is not clear, though, whether these recommendations are indeed followed up in clinical practice. OBJECTIVE: To investigate if rheumatologists that report to agree with existing guidelines indeed follow them up in clinical practice...
2016: RMD Open
https://www.readbyqxmd.com/read/27133019/cognitive-deficits-early-in-the-course-of-rheumatoid-arthritis
#14
Panagiotis Simos, Georgia Ktistaki, Georgia Dimitraki, Emmanouil Papastefanakis, Nikolaos Kougkas, Antonios Fanouriakis, Irini Gergianaki, George Bertsias, Prodromos Sidiropoulos, Evangelos C Karademas
OBJECTIVE: The aim was to examine the severity and prevalence of cognitive difficulties in persons with rheumatoid arthritis (RA) within the first three years of diagnosis. METHOD: One hundred consecutive RA patients aged 28-67 years (90% women) were administered a battery of 6 neuropsychological tests yielding 14 cognitive indices. Self-reported measures of trait anxiety, depression, impact of disease on daily activities, and pain severity were also obtained along with physician-rated disease severity...
September 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27122121/treatment-of-rheumatoid-arthritis-ra-in-india-how-and-by-whom-results-from-a-speciality-clinic-use-of-low-dose-methotrexate-mtx-was-inexplicably-suboptimal
#15
Anand N Malaviya, S B Gogia
This study was conducted in order to study (a) seropositive RA patients for their prior caregivers, diagnosis makers, drugs and doses taken and (b) the disease status at the first visit and the last visit, from the standpoint of whether they received optimum or suboptimum DMARD treatment. Prospectively entered data were extracted from a rheumatology-specific electronic health record for demography, diagnostic delay, prior caregivers, diagnosis makers, intake of DMARDs and glucocorticoids and disease activity state at first presentation and at the last visit using structured query language...
September 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27051232/bone-scintigraphy-in-the-diagnosis-of-rheumatoid-arthritis-is-there-additional-value-of-bone-scintigraphy-with-blood-pool-phase-over-conventional-bone-scintigraphy
#16
Ji Young Kim, Yun Young Choi, Chan Woo Kim, Yoon-Kyoung Sung, Dae-Hyun Yoo
We aimed to investigate the value of bone scintigraphy with additional blood pool phase (BSBP), compared with conventional bone scintigraphy (CBS), in the assessment of rheumatoid arthritis (RA). A total of 242 patients (43 males, 199 females; 14-78 years) with arthralgia, and underwent BSBP were retrospectively analyzed. On the first physical examination, active arthritis was found in 128 of the 242 patients. Clinical diagnosis was made by a rheumatologist on the basis of the 1987 American College of Rheumatology (ACR) criteria, which are considered to be the gold standard...
April 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27022002/not-your-regular-high-cardiac-dysrhythmias-caused-by-loperamide
#17
Rachel Sarah Wightman, Robert S Hoffman, Mary Ann Howland, Brian Rice, Rana Biary, Daniel Lugassy
OBJECTIVE: Loperamide, a non-prescription anti-diarrheal agent, is a peripheral mu-opioid receptor agonist that is excluded from the blood-brain barrier by p-glycoprotein at therapeutic doses. Overdoses of loperamide penetrate the central nervous system (CNS), leading to abuse. We report cardiac conduction abnormalities and dysrhythmias after ingestion of a recreational supra-therapeutic dose of loperamide confirmed with an elevated blood loperamide concentration. CASE DETAILS: A 48-year-old woman with a history of alcohol and benzodiazepine abuse presented to the emergency department (ED) with somnolence, weakness and slurred speech...
June 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/26781784/magnetic-resonance-imaging-in-early-rheumatoid-arthritis-a-multicenter-prospective-study
#18
Ru Li, Xia Liu, Hua Ye, Hai-Hong Yao, Jia-Long Guo, Guang-Tao Li, Xing-Fu Li, Yu Xue, Jin-Xia Zhao, Fei Gu, Qing-Hua Zou, Li-Na Chen, Li-Qi Bi, Zhuo-Li Zhang, He-Jian Zou, Xiang-Yuan Liu, Ling-Yun Sun, Yong-Fei Fang, Ping Zhu, Yin Su, Zhan-Guo Li
To identify the magnetic resonance imaging (MRI) features of hands and wrists in early rheumatoid arthritis (RA). A total of 129 early arthritis patients (≤1 year) were enrolled in the study. At presentation, MRI of the hands was performed, with clinical and laboratory analyses. After a 1-year follow-up, clinical diagnosis of early RA or non-RA was confirmed by two rheumatologists. The characteristics of MRI variables at baseline in RA patients not fulfilling ACR 1987 criteria [RA-87(-)] were compared with those fulfilling ACR1987 criteria [RA-87(+)] and non-RA...
February 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/25128504/serum-14-3-3%C3%AE-is-a-novel-marker-that-complements-current-serological-measurements-to-enhance-detection-of-patients-with-rheumatoid-arthritis
#19
COMPARATIVE STUDY
Walter P Maksymowych, Stanley J Naides, Vivian Bykerk, Katherine A Siminovitch, Dirkjan van Schaardenburg, Maarten Boers, Robert Landewé, Désirée van der Heijde, Paul-P Tak, Mark C Genovese, Michael E Weinblatt, Edward C Keystone, Olga S Zhukov, Rania W Abolhosn, Joanna M Popov, Karin Britsemmer, Arno W van Kuijk, Anthony Marotta
OBJECTIVE: Serum 14-3-3η is a novel joint-derived proinflammatory mediator implicated in the pathogenesis of rheumatoid arthritis (RA). In our study, we assessed the diagnostic utility of 14-3-3η and its association with standard clinical and serological measures. METHODS: A quantitative ELISA was used to assess 14-3-3η levels. Early (n=99) and established patients with RA (n=135) were compared to all controls (n=385), including healthy subjects (n=189). The sensitivity, specificity, positive and negative predictive values of 14-3-3η, and the likelihood ratios (LR) for RA were determined through receiver-operator curve analysis...
November 2014: Journal of Rheumatology
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