Hanjie Hu, Muhammad Umair, Sikandar Ali Khan, Aliya Irshad Sani, Sahar Iqbal, Fatima Khalid, Rizwana Sultan, Mostafa A Abdel-Maksoud, Ayman Mubarak, Turki M Dawoud, Abdul Malik, Ibrahim A Saleh, Abdul Aziz Al Amri, Norah Khaled Algarzae, Ahmad S Kodous, Yasir Hameed
BACKGROUND: Human cell division cycle-associated protein 8 (CDCA8), a critical regulator of mitosis, has been identified as a prospective prognostic biomarker in several cancer types, including breast, colon, and lung cancers. This study analyzed the diagnostic/prognostic potential and clinical implications of CDCA8 across diverse cancers. METHODS: Bioinformatics and molecular experiments. RESULTS: Analyzing TCGA data via TIMER2 and GEPIA2 databases revealed significant up-regulation of CDCA8 in 23 cancer types compared to normal tissues...
2024: American Journal of Translational Research