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PPI AND Kidney

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https://www.readbyqxmd.com/read/27866965/proton-pump-inhibitor-use-and-risk-of-hip-fracture-in-kidney-transplant-recipients
#1
Colin R Lenihan, Sumi Sukumaran Nair, Chandan Vangala, Venkat Ramanathan, Maria E Montez-Rath, Wolfgang C Winkelmayer
BACKGROUND: Posttransplantation bone disease is a significant problem, with few well-evidenced therapeutic options. Proton pump inhibitors (PPIs) are associated with hip fracture in the general population and are widely prescribed for kidney transplant recipients. STUDY DESIGN: A case-control study. SETTING & PARTICIPANTS: From the US Renal Data System, we identified from diagnoses and procedures 231 kidney transplant recipients with a first hip fracture...
November 17, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27846294/identification-and-verification-of-potential-therapeutic-target-genes-in-berberine-treated-zucker-diabetic-fatty-rats-through-bioinformatics-analysis
#2
Yang Sheng Wu, Yi-Tao Chen, Yu-Ting Bao, Zhe-Ming Li, Xiao-Jie Zhou, Jia-Na He, Shi-Jie Dai, Chang Yu Li
BACKGROUND: Berberine is used to treat diabetes and dyslipidemia. However, the effect of berberine on specific diabetes treatment targets is unknown. In the current study, we investigated the effect of berberine on the random plasma glucose, glycated hemoglobin (HbA1C), AST, ALT, BUN and CREA levels of Zucker diabetic fatty (ZDF) rats, and we identified and verified the importance of potential therapeutic target genes to provide molecular information for further investigation of the mechanisms underlying the anti-diabetic effects of berberine...
2016: PloS One
https://www.readbyqxmd.com/read/27802793/identification-of-crucial-mirnas-and-the-targets-in-renal-cortex-of-hypertensive-patients-by-expression-profiles
#3
Guohua Wang, Lan Wu, Zhi Chen, Jinghui Sun
BACKGROUNDS: Defect in kidney is one major reason of hypertension. The study aimed ao uncovering the regulatory mechanisms of miRNAs and the targets in hypertensive kidney. METHODS: Gene expression profile of GSE28345 and miRNA expression profile of GSE28283 were downloaded from GEO database. After data preprocessing, differently expressed genes (DEGs) and miRNAs (DE-miRs) were identified using limma package. Then targets of miRNAs were predicted according to information in relevant databases...
November 2, 2016: Renal Failure
https://www.readbyqxmd.com/read/27777973/systems-biology-analysis-reveals-role-of-mdm2-in-diabetic-nephropathy
#4
Rintaro Saito, Anaïs Rocanin-Arjo, Young-Hyun You, Manjula Darshi, Benjamin Van Espen, Satoshi Miyamoto, Jessica Pham, Minya Pu, Simone Romoli, Loki Natarajan, Wenjun Ju, Matthias Kretzler, Robert Nelson, Keiichiro Ono, Dana Thomasova, Shrikant R Mulay, Trey Ideker, Vivette D'Agati, Ergin Beyret, Juan Carlos Izpisua Belmonte, Hans Joachim Anders, Kumar Sharma
To derive new insights in diabetic complications, we integrated publicly available human protein-protein interaction (PPI) networks with global metabolic networks using metabolomic data from patients with diabetic nephropathy. We focused on the participating proteins in the network that were computationally predicted to connect the urine metabolites. MDM2 had the highest significant number of PPI connections. As validation, significant downregulation of MDM2 gene expression was found in both glomerular and tubulointerstitial compartments of kidney biopsy tissue from 2 independent cohorts of patients with diabetic nephropathy...
October 20, 2016: JCI Insight
https://www.readbyqxmd.com/read/27722500/gd-chelated-poly-propylene-imine-dendrimers-with-densely-organized-maltose-shells-for-enhanced-mr-imaging-applications
#5
Zhijuan Xiong, Yue Wang, Jingyi Zhu, Yao He, Jiao Qu, Christiane Effenberg, Jindong Xia, Dietmar Appelhans, Xiangyang Shi
We report the design of the fourth generation poly(propylene imine) (PPI) glycodendrimers for magnetic resonance (MR) imaging applications. The glycodendrimers were designed to have a densely organized maltose shell (MAL DS) and several tetraazacyclododecane tetraacetic acid (DOTA) ligands that were attached to the periphery of the PPI dendrimers for Gd(iii) chelation. We show that the formed MAL DS-modified PPI dendrimers possess good cytocompatibility and hemocompatibility in the studied concentration range...
October 18, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27650918/a-comparison-of-histamine-receptor-antagonists-versus-proton-pump-inhibitor-gastrointestinal-ulcer-prophylaxis-in-kidney-transplant-recipients
#6
Ginger E Rouse, Karen Hardinger, Demetra Tsapepas, Eric M Tichy
INTRODUCTION: There are several different agents that can be used for gastrointestinal (GI) ulcer prophylaxis in posttransplant recipients, such as histamine-2 receptor antagonists (H2RA) or proton pump inhibitors (PPIs). RESEARCH QUESTION: This study was conducted to compare the incidence of adverse kidney events in transplant recipients who received prophylaxis with H2RAs or PPIs. DESIGN: This retrospective study included all kidney transplant recipients from 3 transplant centers who were transplanted in 2009 through 2011...
September 20, 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/27607343/gastric-acid-secretion
#7
Mitchell L Schubert
PURPOSE OF REVIEW: The present review summarizes the past year's literature, both clinical and basic science, regarding neuroendocrine and intracellular regulation of gastric acid secretion and proper use of antisecretory medications. RECENT FINDINGS: Gastric acid kills microorganisms, modulates the gut microbiome, assists in digestion of protein, and facilitates absorption of iron, calcium, and vitamin B12. The main stimulants of acid secretion are gastrin, released from antral G cells; histamine, released from oxyntic enterochromaffin-like cells; and acetylcholine, released from antral and oxyntic intramural neurons...
November 2016: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/27492273/proton-pump-inhibitors-are-not-associated-with-acute-kidney-injury-in-critical-illness
#8
Joon Lee, Roger G Mark, Leo Anthony Celi, John Danziger
Recent epidemiologic data linking proton pump inhibitor (PPI) use to acute and chronic kidney dysfunction is yet to be validated in other populations, and mechanisms have not been explored. Using a large, well phenotyped inception cohort of 15 063 critically ill patients, we examined the risk of acute kidney injury (AKI), as defined by the Kidney Disease Improving Global Outcomes criteria guidelines, according to prior use of a PPI, histamine-2 receptor antagonist (H2 RA), or neither. A total of 3725 (24...
December 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27487959/proton-pump-inhibitors-are-associated-with-increased-risk-of-development-of-chronic-kidney-disease
#9
Pradeep Arora, Anu Gupta, Mojgan Golzy, Nilang Patel, Randolph L Carter, Kabir Jalal, James W Lohr
BACKGROUND: Acute interstitial nephritis secondary to proton pump inhibitors (PPIs) frequently goes undiagnosed due to its subacute clinical presentation, which may later present as chronic kidney disease (CKD). We investigated the association of PPI use with the development of CKD and death. METHODS: Two separate retrospective case-control study designs were employed with a prospective logistic regression analysis of data to evaluate the association of development of CKD and death with PPI use...
August 3, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27461215/can-intestinal-phosphate-binding-or-inhibition-of-hydroxyapatite-growth-in-the-vascular-wall-halt-the-progression-of-established-aortic-calcification-in-chronic-kidney-disease
#10
Ellen Neven, Britt Opdebeeck, Annelies De Maré, Rida Bashir-Dar, Geert Dams, Rita Marynissen, Geert J Behets, Anja Verhulst, Bruce L Riser, Patrick C D'Haese
Vascular calcification significantly contributes to mortality in chronic kidney disease (CKD) patients. Sevelamer and pyrophosphate (PPi) have proven to be effective in preventing vascular calcification, the former by controlling intestinal phosphate absorption, the latter by directly interfering with the hydroxyapatite crystal formation. Since most patients present with established vascular calcification, it is important to evaluate whether these compounds may also halt or reverse the progression of preexisting vascular calcification...
November 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27399102/association-between-gastroesophageal-reflux-disease-and-coronary-heart-disease-a-nationwide-population-based-analysis
#11
Chien-Hua Chen, Cheng-Li Lin, Chia-Hung Kao
In this study, we aimed to determine the association between gastroesophageal reflux disease (GERD) and subsequent coronary heart disease (CHD) development, if any, and to evaluate whether longer use of proton pump inhibitors (PPIs) increases the risk of CHD.Patients diagnosed with GERD between 2000 and 2011 were identified as the study cohort (n = 12,960). Patients without GERD were randomly selected from the general population, frequency-matched with the study group according to age, sex, and index year, and evaluated as the comparison cohort (n = 51,840)...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27278387/a-new-method-for-classifying-different-phenotypes-of-kidney-transplantation
#12
Dong Zhu, Zexian Liu, Zhicheng Pan, Mengjia Qian, Linyan Wang, Tongyu Zhu, Yu Xue, Duojiao Wu
For end-stage renal diseases, kidney transplantation is the most efficient treatment. However, the unexpected rejection caused by inflammation usually leads to allograft failure. Thus, a systems-level characterization of inflammation factors can provide potentially diagnostic biomarkers for predicting renal allograft rejection. Serum of kidney transplant patients with different immune status were collected and classified as transplant patients with stable renal function (ST), impaired renal function with negative biopsy pathology (UNST), acute rejection (AR), and chronic rejection (CR)...
August 2016: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/27086964/effect-of-proton-pump-inhibitors-on-magnesium-balance-is-there-a-link-to-cardiovascular-risk
#13
Laura Francesca Pisani, Elisabetta Filippi, Sara Vavassori, Nadia Munizio, Maurizio Vecchi, Luca Pastorelli
Magnesium (Mg(2+)) is the second most copious element inside human cells and the fourth most abundant positively charged ion in the human body. It is of central importance for a broad variety of physiological processes, including intracellular signaling, neuronal excitability, muscle contraction, bone formation and enzyme activation. Its overall balance is tightly regulated by the concerted actions of the intestine, bones and kidneys. Disturbance of this balance can have serious consequences. Symptoms of hypomagnesaemia include tetany, seizures and cardiac arrhythmias, whereas hypermagnesaemia may cause cardiovascular and neuromuscular abnormalities...
March 1, 2016: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/27072818/ppis-and-kidney-disease-from-ain-to-ckd
#14
REVIEW
Dennis G Moledina, Mark A Perazella
Proton pump inhibitors (PPIs) are commonly prescribed and available over-the-counter, and are taken by millions of patients around the world, often for many months to years. While PPIs have an excellent overall safety profile, concerns have been raised about adverse renal events, specifically their association with acute interstitial nephritis (AIN). While only a small proportion of patients develop AIN from PPIs, these drugs are now a common cause of drug-induced AIN in the developed world due to their widespread and prolonged use...
October 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/27044846/dtb-select-4-april-2016
#15
(no author information available yet)
Nicorandil now second-line in the treatment of stable angina ● EMA to review use of metformin in kidney disease ● PPI use linked to raised risk of kidney disease ● Text messaging and drug adherence ● Specify levonorgestrel-releasing IUS by brand name ● Clarithromycin and cardiovascular risk ● Grapefruit juice and statins ● Can ibuprofen reduce antibiotic prescriptions for uncomplicated UTIs?
April 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27004722/routine-prophylaxis-with-proton-pump-inhibitors-and-post-transplant-complications-in-kidney-transplant-recipients-undergoing-early-corticosteroid-withdrawal
#16
Alesa Y Courson, John R Lee, Meredith J Aull, Jennifer H Lee, Sandip Kapur, Jennifer K McDermott
Surgical stress, corticosteroids, and mycophenolate may contribute to gastrointestinal ulcers/bleeding after kidney transplantation. Prophylactic acid suppression with H2RAs or PPIs is often utilized after transplantation, although unclear if truly indicated after early corticosteroid withdrawal (CSWD). PPIs have been associated with increased risks of Clostridium difficile infection (CDI), pneumonia, and acute rejection. This retrospective cohort study investigated benefits and risks of prolonged PPI use following kidney transplantation and included 286 kidney recipients undergoing CSWD within five d of transplant who were maintained on tacrolimus and mycophenolate mofetil/sodium...
June 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/26978517/acute-middle-gastrointestinal-bleeding-risk-associated-with-nsaids-antithrombotic-drugs-and-ppis-a-multicenter-case-control-study
#17
MULTICENTER STUDY
Naoyoshi Nagata, Ryota Niikura, Atsuo Yamada, Toshiyuki Sakurai, Takuro Shimbo, Yuka Kobayashi, Makoto Okamoto, Yuzo Mitsuno, Keiji Ogura, Yoshihiro Hirata, Kazuma Fujimoto, Junichi Akiyama, Naomi Uemura, Kazuhiko Koike
BACKGROUND: Middle gastrointestinal bleeding (MGIB) risk has not been fully investigated due to its extremely rare occurrence and the need for multiple endoscopies to exclude upper and lower gastrointestinal bleeding. This study investigated whether MGIB is associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs), low-dose aspirin (LDA), thienopyridines, anticoagulants, and proton-pump inhibitors (PPIs), and whether PPI use affects the interactions between MGIB and antithrombotic drugs...
2016: PloS One
https://www.readbyqxmd.com/read/26893674/revealing-the-role-of-vegfa-in-clear-cell-sarcoma-of-the-kidney-by-protein-protein-interaction-network-and-significant-pathway-analysis
#18
Zhikui Wang, Zhaoxia Wang, Zhongqi Zhou, Yueqin Ren
Despite clear cell sarcoma of the kidney (CCSK) being the second most common renal tumor in children, its mechanism has not yet been fully investigated. The aim of the present study was to investigate the potential role of vascular endothelial growth factor A (VEGFA) in CCSK development. Following preprocessing of the original GSE2712 data, the differentially-expressed genes (DEGs) between 14 CCSK and 3 fetal kidney samples were identified through Significance Analysis of Microarrays, using the R package. Pathway enrichment analysis was then performed on the DEGs...
February 2016: Oncology Letters
https://www.readbyqxmd.com/read/26872254/inhibition-of-gastric-acid-secretion-by-h2-receptor-antagonists-associates-a-definite-risk-of-enteric-peritonitis-and-infectious-mortality-in-patients-treated-with-peritoneal-dialysis
#19
Miguel Pérez-Fontan, Daniela Machado Lopes, Alba García Enríquez, Beatriz López-Calviño, Andrés López-Muñiz, Teresa García Falcón, Ana Rodríguez-Carmona
BACKGROUND: Evidences linking treatment with inhibitors of gastric acid secretion (IGAS) and an increased risk of serious infections are inconclusive, both in the population at large and in the particular case of patients with chronic kidney disease. We have undertaken an investigation to disclose associations between treatment with IGAS and infectious outcomes, in patients undergoing chronic Peritoneal Dialysis (PD). METHOD: Observational, historic cohort, single center design...
2016: PloS One
https://www.readbyqxmd.com/read/26840539/identification-of-genes-and-pathways-associated-with-kidney-ischemia-reperfusion-injury-by-bioinformatics-analyses
#20
Wei Feng, Rongwei Tang, Xudong Ye, Chao Xue, Yunhua Liao
BACKGROUND/AIMS: Ischemia-reperfusion (IR) injury in the kidney is a major cause of acute kidney injury in humans. However, the molecular mechanisms responsible for the progression of kidney IR injury still need to be explored. In this study, we aimed to explore the underlying genes and pathways associated with kidney IR injury. METHODS: Gene microarray of GSE27274 was downloaded from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) between kidney IR injury and kidney IR rat samples were analyzed...
2016: Kidney & Blood Pressure Research
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