Jia-Lu Liu, Xiao-Wen Wang, Cui-Hua Liu, Duan Ma Xiao-Jie Gao, Xiao-Yun Jiang, Jian-Hua Mao, Guang-Hua Zhu, Ai-Hua Zhang, Mo Wang, Xi-Qiang Dang, Jie-Qiu Zhuang, Yu-Feng Li, Hai-Tao Bai, Rui-Feng Zhang, Tong Shen, Yun-Li Bi, Yu-Bo Sun, Xiang Wang, Bing-Bing Wu, Jing Chen, Jia Rao, Xiao-Shan Tang, Qian Shen, Hong Xu
BACKGROUND: Congenital anomalies of the kidney and urinary tracts (CAKUT) are the leading cause of kidney failure in children with phenotypic and genotypic heterogeneity. Our objective was to describe the genetic spectrum and identify the risk factors for kidney failure in children with CAKUT. METHODS: Clinical and genetic data were derived from a multicenter network (Chinese Children Genetic Kidney Disease Database, CCGKDD) and the Chigene database. A total of 925 children with CAKUT who underwent genetic testing from 2014 to 2020 across China were studied...
December 22, 2022: Nephrology, Dialysis, Transplantation