keyword
MENU ▼
Read by QxMD icon Read
search

chronic hepatitis e

keyword
https://www.readbyqxmd.com/read/29782205/nad-repletion-produces-no-therapeutic-effect-in-mice-with-respiratory-chain-complex-iii-deficiency-and-chronic-energy-deprivation
#1
Janne Purhonen, Jayasimman Rajendran, Saara Tegelberg, Olli-Pekka Smolander, Eija Pirinen, Jukka Kallijärvi, Vineta Fellman
Biosynthetic precursors of NAD+ can replenish a decreased cellular NAD+ pool and, supposedly via sirtuin (SIRT) deacetylases, improve mitochondrial function. We found decreased hepatic NAD+ concentration and downregulated biosynthesis in Bcs1lp.S78G knock-in mice with respiratory chain complex III deficiency and mitochondrial hepatopathy. Aiming at ameliorating disease progression via NAD+ repletion and improved mitochondrial function, we fed these mice nicotinamide riboside (NR), a NAD+ precursor. A targeted metabolomics verified successful administration and suggested enhanced NAD+ biosynthesis in the treated mice, although hepatic NAD+ concentration was unchanged at the end point...
May 21, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29775812/virus-entry-and-its-inhibition-to-prevent-and-treat-hepatitis-b-and-hepatitis-d-virus-infections
#2
REVIEW
Thomas Tu, Stephan Urban
While chronic infection with the human hepatitis B virus (HBV) and hepatitis delta virus (HDV) inflict major health burdens worldwide, current therapies cannot cure patients. One possible novel approach is blocking virus entry to prevent the establishment of infection in naïve hepatocytes. As HBV and HDV use identical viral envelope proteins and the same entry mechanisms, such a strategy would target both viruses. Entry inhibitors (e.g. neutralizing antibodies) have been relegated to the limited role of prophylaxis...
May 15, 2018: Current Opinion in Virology
https://www.readbyqxmd.com/read/29772814/chronic-and-occult-hepatitis-b-virus-infection-in-pregnant-women-in-botswana
#3
Tshepiso Mbangiwa, Ishmael Kasvosve, Motswedi Anderson, Prisca K Thami, Wonderful T Choga, Austen Needleman, Bonolo B Phinius, Sikhulile Moyo, Melvin Leteane, Jean Leidner, Jason T Blackard, Gloria Mayondi, Betsy Kammerer, Rosemary M Musonda, Max Essex, Shahin Lockman, Simani Gaseitsiwe
The hepatitis B virus (HBV) is a global problem; however, the burden of HBV infection in pregnant women in Botswana is unknown. We sought to determine the prevalence of chronic and occult HBV infection in human immunodeficiency virus (HIV)-infected and -uninfected pregnant women in Botswana. Samples from 752 pregnant women were tested for hepatitis B surface antigen (HBsAg), and HBsAg-positive samples were tested for hepatitis B e antigen (HBeAg) and HBV DNA load. Samples that were HBsAg negative were screened for occult HBV infection by determining the HBV DNA load...
May 17, 2018: Genes
https://www.readbyqxmd.com/read/29772748/drug-delivery-strategies-for-antivirals-against-hepatitis-b-virus
#4
REVIEW
Latavia Singh, Sunaina Indermun, Mershen Govender, Pradeep Kumar, Lisa C du Toit, Yahya E Choonara, Viness Pillay
Chronic hepatitis B virus (HBV) infection poses a significant health challenge due to associated morbidity and mortality from cirrhosis and hepatocellular cancer that eventually results in the breakdown of liver functionality. Nanotechnology has the potential to play a pivotal role in reducing viral load levels and drug-resistant HBV through drug targeting, thus reducing the rate of evolution of the disease. Apart from tissue targeting, intracellular delivery of a wide range of drugs is necessary to exert a therapeutic action in the affected organelles...
May 17, 2018: Viruses
https://www.readbyqxmd.com/read/29769038/impact-of-new-daa-therapy-on-real-clinical-practice-a-multicenter-region-wide-cohort-study
#5
Simone Lanini, Paola Scognamiglio, Alessandra Mecozzi, Lorella Lombardozzi, Vincenzo Vullo, Mario Angelico, Antonio Gasbarrini, Gloria Taliani, Adolfo Francesco Attili, Carlo Federico Perno, Adriano De Santis, Vincenzo Puro, Fabio Cerqua, Gianpiero D'Offizi, Adriano Pellicelli, Orlando Armignacco, Francesco Saverio Mennini, Massimo Siciliano, Enrico Girardi, Vincenzo Panella, Giuseppe Ippolito
BACKGROUND: Management of chronic hepatitis C (CHC) has significantly accelerated in the last few years. Currently, second generation direct acting antivirals (DAAs) promise clearance of infection in most of patients. Here we present the results of the first analysis carried out on data of Lazio clinical network for DAAs. METHODS: The study was designed as a multicenter cohort: a) to assess the evolution of treatment during the first 24 months of the activity of the Clinical Network; b) to report overall efficacy of treatments; c) to analyze potential factors associated with lack of virological response at 12 weeks after therapy (SVR12); d) to evaluate the variation of ALT at baseline and 12 weeks after therapy in those who achieved SVR12 in comparison to those who did not...
May 16, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29768691/detection-of-hepatitis-b-virus-dna-among-chronic-and-potential-occult-hbv-patients-in-resource-limited-settings-by-loop-mediated-isothermal-amplification-assay
#6
Arifa Akram, S M Rashedul Islam, Saif Ullah Munshi, Shahina Tabassum
Transmission of Hepatitis B Virus (HBV) usually occurs due to the transfusion of blood or blood products from chronic HBV (CHB) or occult HBV infected (OBI) patients. Besides serological tests e.g. HBsAg and anti-HBc (total), detection of HBV-DNA is necessary for the diagnosis of OBI patients. Different nucleic acid tests (NATs) including real-time-Polymerase Chain Reaction (qPCR) are used for the detect HBV-DNA. The NATs are expensive and require technical expertise which are barriers to introducing them in resource-limited settings...
May 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29764511/high-serum-levels-of-pregenomic-rna-reflect-frequently-failing-reverse-transcription-in-hepatitis-b-virus-particles
#7
Kasthuri Prakash, Gustaf E Rydell, Simon B Larsson, Maria Andersson, Gunnar Norkrans, Heléne Norder, Magnus Lindh
BACKGROUND: Hepatocytes infected by hepatitis B virus (HBV) produce different HBV RNA species, including pregenomic RNA (pgRNA), which is reverse transcribed during replication. Particles containing HBV RNA are present in serum of infected individuals, and quantification of this HBV RNA could be clinically useful. METHODS: In a retrospective study of 95 patients with chronic HBV infection, we characterised HBV RNA in serum in terms of concentration, particle association and sequence...
May 15, 2018: Virology Journal
https://www.readbyqxmd.com/read/29761927/on-the-potential-role-of-intestinal-microbial-community-in-hepatocarcinogenesis-in-chronic-hepatitis-b
#8
REVIEW
Ashraf Mohamadkhani
The chronic infection of hepatitis B virus (HBV) is the most potent risk factor for the development of cirrhosis and hepatocellular carcinoma (HCC). The association of intestinal microbiota alteration with progressive liver disease has been investigated in recent studies. Overgrowth of potentially pathogenic bacteria of gram-negative species and, in particular, a significant increase in the fecal count of Escherichia coli (E. coli) are characterized in the presence of HCC. This study was conducted to describe the characteristics of the intestinal microbiota related to the presence of HCC in HBV-carrier patients...
May 15, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29757135/a-nationwide-retrospective-study-on-prevalence-of-hepatitis-e-virus-infection-in-italian-blood-donors
#9
Enea Spada, Simonetta Pupella, Giulio Pisani, Roberto Bruni, Paola Chionne, Elisabetta Madonna, Umbertina Villano, Matteo Simeoni, Sara Fabi, Giuseppe Marano, Cinzia Marcantonio, Patrizio Pezzotti, Anna R Ciccaglione, Giancarlo M Liumbruno
BACKGROUND: In Europe, hepatitis E virus (HEV) infection is mainly a food-borne zoonosis, but it can also be transmitted by blood transfusion. It is usually a mild and self-limited infection. However, immunocompromised persons, who are also those more likely to undergo blood transfusions, may develop chronic hepatitis and often cirrhosis. Since this is a potential threat to blood safety, we aimed to investigate HEV prevalence in Italian blood donors. MATERIALS AND METHODS: We used plasma donations collected during 2015-2016 by blood services (BS) scattered throughout the Italian regions and intended for the production of plasma-derived medicines...
May 4, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29753822/the-protective-role-of-selenium-against-cadmium-induced-hepatotoxicity-in-laying-hens-expression-of-hsps-and-inflammation-related-genes-and-modulation-of-elements-homeostasis
#10
Runxiang Zhang, Yanhong Liu, Lu Xing, Ning Zhao, Qimin Zheng, Jianhong Li, Jun Bao
The purpose of this study was to examine the potential role of high selenium (Se) diets in alleviating chronic cadmium (Cd) hepatic toxicity in laying hens. In the present study, 128 healthy 31-week-old laying hens were fed a diet supplemented with Se (Na2 SeO3 , 2 mg/kg), Cd (CdCl2 , 150 mg/kg), or both Se and Cd (150 mg/kg of CdCl2 and 2 mg/kg of Na2 SeO3 ) for 90 days. The expression levels of heat shock proteins (Hsps, including Hsp60, Hsp70 and Hsp90) and inflammation-related factors, including nuclear factor-kappa B p50 (NF-κB), cyclooxygenase-2 (COX-2), prostaglandin E synthases (PTGES), interleukin 1-beta (IL-1β), and tumor necrosis factor-α (TNF-α) were investigated...
May 10, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29753083/level-of-hepatitis-b-hb-core-antibody-associates-with-seroclearance-of-hbv-dna-and-hb-surface-antigen-in-hb-e-antigen-seronegative-patients
#11
Hui-Han Hu, Jessica Liu, Chia-Ling Chang, Chin-Lan Jen, Mei-Hsuan Lee, Sheng-Nan Lu, Li-Yu Wang, Yuan Quan, Ning-Shao Xia, Chien-Jen Chen, Pei-Jer Chen, Hwai-I Yang
BACKGROUND & AIMS: Although a low level of hepatitis B surface antigen (HBsAg) is a marker of hepatitis B virus (HBV) seroclearance, additional biomarkers are needed for more accurate prediction. We investigated whether quantification of antibody against HBV core protein (anti-HBc) can identify patients with undetectable levels of HBV DNA and HBsAg seroclearance among those who were HBV e antigen (HBeAg)-seronegative. METHODS: We performed a retrospective analysis of data from a community-based cohort of individuals (30-65 years old) in Taiwan who were HBsAg seropositive, anti-HCV negative, and free of cirrhosis and or liver cancer, recruited from 1991 through 1992, and evaluated every 6-12 months until June 30, 2004...
May 9, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29751272/overcoming-immune-tolerance-in-chronic-hepatitis-b-by-therapeutic-vaccination
#12
REVIEW
Claudia Dembek, Ulrike Protzer, Michael Roggendorf
The currently used nucleoside analogs (i.e. entecavir and tenofovir) with high barrier-to-resistance efficiently suppress viral replication, limit inflammation and reduce the sequelae of chronic hepatitis B, but cannot cure the disease and thus have to be applied long-term. Therapeutic vaccination as an approach to cure chronic hepatitis B has shown promising pre-clinical results, nevertheless the proof of its efficacy in clinical trials is still missing. This may be partially due to suboptimal vaccine design...
May 8, 2018: Current Opinion in Virology
https://www.readbyqxmd.com/read/29743800/a-case-of-acute-on-chronic-liver-failure-aclf-due-to-an-uncommon-acute-and-chronic-event
#13
Swastik Agrawal, Baldev S Rana, Suvradeep Mitra, Ajay Duseja, Ashim Das, Radha K Dhiman, Yogesh Chawla
Acute on Chronic Liver Failure (ACLF) is an acute worsening of patients with chronic liver disease resulting in liver failure. Usually these patients have cirrhosis as the underlying liver disease with alcohol being the most common etiology. Common hepatitic illnesses causing acute worsening in Indian patients of ACLF include alcoholic hepatitis, acute viral hepatitis related to hepatitis E virus and acute flare in chronic hepatitis B. We report an adult case of ACLF due acute viral hepatitis related to hepatitis A virus infection superimposed on nonalcoholic steatohepatitis without cirrhosis...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743793/bone-health-and-impact-of-tenofovir-treatment-in-men-with-hepatitis-b-related-chronic-liver-disease
#14
Kattiparambil G Sajith, Nitin Kapoor, Sahana Shetty, Ashish Goel, Uday Zachariah, Chundamannil E Eapen, Thomas V Paul
Background: Chronic Liver Disease (CLD) has been shown to have an adverse impact on bone health. Hepatitis-B related CLD and its treatment with tenofovir may have additional effects on skeleton. Objective: To study the impact of HBV related CLD and its treatment with Tenofovir on bone health in Indian subjects. Methods: This cross sectional study included men (18-60 years) and comprised of three groups: Group-1 was treatment naïve HBV related CLD ( n  = 79), Group-2 those with HBV related CLD on tenofovir for at least 1 year ( n  = 136), Group-3 age, sex and Body Mass Index (BMI) matched healthy controls ( n  = 58)...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29741634/serum-hbv-rna-as-a-predictor-of-peginterferon-alfa-2a-40kd-response-in-patients-with-hbeag-positive-chronic-hepatitis-b
#15
Florian van Bömmel, Alena van Bömmel, Alexander Krauel, Cynthia Wat, Vedran Pavlovic, Lei Yang, Danilo Deichsel, Thomas Berg, Stephan Böhm
Background: Hepatitis B virus (HBV) RNA is a novel serum biomarker that has the potential to predict treatment response in patients with chronic hepatitis B. We explored whether HBV RNA serum levels can predict hepatitis B e antigen (HBeAg) seroconversion in patients treated with peginterferon alfa-2a. Methods: Serum samples from HBeAg-positive patients previously treated with peginterferon alfa-2a in two large randomized controlled trials were retrospectively analyzed...
May 8, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29741285/systematic-review-and-meta-analysis-development-of-hepatocellular-carcinoma-in-chronic-hepatitis-b-patients-with-hepatitis-e-antigen-seroconversion
#16
Tai-Cheng Zhou, Xin Lai, Mu-Hua Feng, Yang Tang, Liang Zhang, Jia Wei
Hepatitis B e antigen (HBeAg) seroconversion is considered to have significantly favorable clinical outcomes for patients with chronic hepatitis B (CHB). However, inconsistent study results suggest that hepatocellular carcinoma (HCC) still occurs in patients with HBeAg seroconversion. We performed a systematic review and meta-analysis to determine the incidence of HCC in patients with CHB after HBeAg seroconversion. Web of Science, PubMed and EMBASE databases were searched through July 2017. The incidence of HCC in CHB patients after HBeAg seroconversion was pooled using a random-effects model or fix-effects model...
May 9, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29740432/unique-and-common-features-of-innate-like-human-v%C3%AE-2-%C3%AE-%C3%AE-t-cells-and-mucosal-associated-invariant-t-cells
#17
Nicholas M Provine, Benedikt Binder, Michael E B FitzPatrick, Anita Schuch, Lucy C Garner, Kate D Williamson, Bonnie van Wilgenburg, Robert Thimme, Paul Klenerman, Maike Hofmann
Mucosal-associated invariant T (MAIT) cells are innate-like T cells abundant in humans that can be activated in a TCR-independent manner by inflammatory and antiviral cytokines. In humans, the capacity for TCR-independent activation is functionally linked to a transcriptional program that can be identified by the expression of the C-type lectin receptor, CD161. In addition to MAIT cells, it has been demonstrated that a subset of γδT cells expresses CD161 and can be activated by TCR-independent cytokine stimulation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29739903/identification-of-the-intragenomic-promoter-controlling-hepatitis-e-virus-subgenomic-rna-transcription
#18
Qiang Ding, Ila Nimgaonkar, Nicholas F Archer, Yaron Bram, Brigitte Heller, Robert E Schwartz, Alexander Ploss
Approximately 20 million hepatitis E virus (HEV) infections occur annually in both developing and industrialized countries. Most infections are self-limiting, but they can lead to chronic infections and cirrhosis in immunocompromised patients, and death in pregnant women. The mechanisms of HEV replication remain incompletely understood due to scarcity of adequate experimental platforms. HEV undergoes asymmetric genome replication, but it produces an additional subgenomic (SG) RNA encoding the viral capsid and a viroporin in partially overlapping open reading frames...
May 8, 2018: MBio
https://www.readbyqxmd.com/read/29739341/hbv-and-hiv-viral-load-but-not-microbial-translocation-or-immune-activation-are-associated-with-liver-fibrosis-among-patients-in-south-africa
#19
Tongai Gibson Maponga, Monique I Andersson, Christoffel J van Rensburg, Joop E Arends, Jantjie Taljaard, Wolfgang Preiser, Richard H Glashoff
BACKGROUND: Co-infection with HIV negatively impacts the progression of chronic hepatitis B virus (HBV) infection, including causing rapid progression to liver fibrosis. Sub-Saharan Africa represents arguably the most important intersection of high endemicity of both chronic hepatitis B virus (HBV) infection and HIV infection. METHODS: We recruited 46 HBV/HIV-co-infected; 47 HBV-monoinfected; 39 HIV-monoinfected; and 37 HBV/HIV-uninfected patients from Tygerberg Hospital, Cape Town, South Africa...
May 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29739076/quantitative-hepatitis-b-e-antigen-a-better-predictor-of-hepatitis-b-virus-dna-than-quantitative-hepatitis-b-surface-antigen
#20
Shuaibu A Hudu, Mohd T Niazlin, Syafinaz A Nordin, Mohammed I Saeed, Soek S Tan, Haniza Omar, Hamiza Shahar, Zamberi Sekawi
BACKGROUND: Hepatitis B surface antigen is usually secreted by infected hepatocytes in the form of subviral particles rather than infectious virions, while the hepatitis B e antigen originates from the core gene and is modified and secreted by hepatocytes into the circulation and functions as a marker of active viral replication. This study aimed to study the relationship between HBV DNA and quantitative hepatitis B surface and e antigen in Malaysian patients. METHODS: A total of 82 chronic hepatitis B patients were recruited for this study from the Hepatology Department of Selayang Hospital...
April 1, 2018: Clinical Laboratory
keyword
keyword
80385
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"