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https://www.readbyqxmd.com/read/28437661/ecological-patterns-of-seed-microbiome-diversity-transmission-and-assembly
#1
REVIEW
Ashley Shade, Marie-Agnès Jacques, Matthieu Barret
Seeds are involved in the transmission of microorganisms from one plant generation to another and consequently act as the initial inoculum for the plant microbiota. The purpose of this mini-review is to provide an overview of current knowledge on the diversity, structure and role of the seed microbiota. The relative importance of the mode of transmission (vertical vs horizontal) of the microbial entities composing the seed microbiota as well as the potential connections existing between seed and other plant habitats such as the anthosphere and the spermosphere is discussed...
April 21, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/28434975/protection-of-pc12%C3%A2-cells-from-cocaine-induced-cell-death-by-inhibiting-mitochondrial-permeability-transition
#2
Frederic Lamarche, Cecile Cottet-Rousselle, Luc Barret, Eric Fontaine
Cocaine abuse induces brain injury and neurodegeneration by a mechanism that has not yet been fully elucidated. Mitochondria play a key role in cell death processes, notably through the opening of the permeability transition pore (PTP). In this work, we examined the involvement of the PTP in cocaine-induced toxicity in PC12 cell lines. We used two different PTP inhibitors -i.e. cyclosporin A (CsA) and metformin-to assess their ability to counteract the cocaine induced effects. We first observed that a 48 h exposure to cocaine strongly sensitized cells to calcium overload, as measured by the calcium retention capacity...
April 20, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28427157/the-anti-tumor-efficacy-of-3c23k-a-glyco-engineered-humanized-anti-misrii-antibody-in-an-ovarian-cancer-model-is-mainly-mediated-by-engagement-of-immune-effector-cells
#3
Pauline Estupina, Alexandre Fontayne, Jean-Marc Barret, Nathalie Kersual, Olivier Dubreuil, Marion Le Blay, Alexandre Pichard, Marta Jarlier, Martine Pugnière, Maëva Chauvin, Thierry Chardès, Jean-Pierre Pouget, Emmanuel Deshayes, Alexis Rossignol, Toufik Abache, Christophe de Romeuf, Aurélie Terrier, Lucie Verhaeghe, Christine Gaucher, Jean-François Prost, André Pèlegrin, Isabelle Navarro-Teulon
Ovarian cancer is the leading cause of death in women with gynecological cancers and despite recent advances, new and more efficient therapies are crucially needed. Müllerian Inhibiting Substance type II Receptor (MISRII, also named AMHRII) is expressed in most ovarian cancer subtypes and is a novel potential target for ovarian cancer immunotherapy. We previously developed and tested 12G4, the first murine monoclonal antibody (MAb) against human MISRII. Here, we report the humanization, affinity maturation and glyco-engineering steps of 12G4 to generate the Fc-optimized 3C23K MAb, and the evaluation of its in vivo anti-tumor activity...
February 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28405321/the-expansion-of-endoscopic-submucosal-dissection-in-france-a-prospective-nationwide-survey
#4
Maximilien Barret, Vincent Lepilliez, Dimitri Coumaros, Stanislas Chaussade, Sarah Leblanc, Thierry Ponchon, Fabien Fumex, Edouard Chabrun, Paul Bauret, Christophe Cellier, Emmanuel Coron, Philippe Bichard, Philippe Bulois, Antoine Charachon, Gabriel Rahmi, Serge Bellon, Marc Lerhun, Jean-Pierre Arpurt, Stéphane Koch, Bertrand Napoleon, Eric Vaillant, Anouk Esch, Said Farhat, Francoise Robin, Nadira Kaddour, Frédéric Prat
INTRODUCTION: Early reports of endoscopic submucosal dissection (ESD) in Europe suggested high complication rates and disappointing outcomes compared to publications from Japan. Since 2008, we have been conducting a nationwide survey to monitor the outcomes and complications of ESD over time. MATERIAL AND METHODS: All consecutive ESD cases from 14 centers in France were prospectively included in the database. Demographic, procedural, outcome and follow-up data were recorded...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28400148/accelerated-re-epithelialization-of-partial-thickness-skin-wounds-by-a-topical-betulin-gel-results-of-a-randomized-phase-iii-clinical-trials-program
#5
Juan P Barret, Fred Podmelle, Břetislav Lipový, Hans-Oliver Rennekampff, Hauke Schumann, Agnes Schwieger-Briel, Tobias R Zahn, Hans-Robert Metelmann
The clinical significance of timely re-epithelialization is obvious in burn care, since delayed wound closure is enhancing the risk of wound site infection and extensive scarring. Topical treatments that accelerate wound healing are urgently needed to reduce these sequelae. Evidence from preliminary studies suggests that betulin can accelerate the healing of different types of wounds, including second degree burns and split-thickness skin graft wounds. The goal of this combined study program consisting of two randomized phase III clinical trials in parallel is to evaluate whether a topical betulin gel (TBG) is accelerating re-epithelialization of split-thickness skin graft (STSG) donor site wounds compared to standard of care...
April 8, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28385107/association-of-household-income-level-and-in-hospital-mortality-in-patients-with-sepsis-a-nationwide-retrospective-cohort-analysis
#6
Barret Rush, Katie Wiskar, Leo Anthony Celi, Keith R Walley, James A Russell, Robert C McDermid, John H Boyd
OBJECTIVE: Associations between low socioeconomic status (SES) and poor health outcomes have been demonstrated in a variety of conditions. However, the relationship in patients with sepsis is not well described. We investigated the association of lower household income with in-hospital mortality in patients with sepsis across the United States. METHODS: Retrospective nationwide cohort analysis utilizing the Nationwide Inpatient Sample (NIS) from 2011. Patients aged 18 years or older with sepsis were included...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28375444/self-assembling-peptide-matrix-for-the-prevention-of-esophageal-stricture-after-endoscopic-resection-a-randomized-controlled-trial-in-a-porcine-model
#7
M Barret, B Bordaçahar, F Beuvon, B Terris, M Camus, R Coriat, S Chaussade, F Batteux, F Prat
Esophageal stricture formation after extensive endoscopic resection remains a major limitation of endoscopic therapy for early esophageal neoplasia. This study assessed a recently developed self-assembling peptide (SAP) matrix as a wound dressing after endoscopic resection for the prevention of esophageal stricture. Ten pigs were randomly assigned to the SAP or the control group after undergoing a 5-cm-long circumferential endoscopic submucosal dissection of the lower esophagus. Esophageal diameter on endoscopy and esophagogram, weight variation, and histological measurements of fibrosis, granulation tissue, and neoepithelium were assessed in each animal...
May 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28360455/a-feasibility-study-of-high-strength-bi-2223-conductor-for-high-field-solenoids
#8
A Godeke, D V Abraimov, E Arroyo, N Barret, M D Bird, A Francis, J Jaroszynski, D V Kurteva, W D Markiewicz, E L Marks, W S Marshall, D M McRae, P D Noyes, R C P Pereira, Y L Viouchkov, R P Walsh, J M White
We performed a feasibility study on a high-strength Bi2-x Pb x Sr2Ca2Cu3O10-x (Bi-2223) tape conductor for high-field solenoid applications. The investigated conductor, DI-BSCCO Type HT-XX, is a pre-production version of Type HT-NX, which has recently become available from Sumitomo Electric Industries (SEI). It is based on their DI-BSCCO Type H tape, but laminated with a high-strength Ni-alloy. We used stress-strain characterizations, single- and double-bend tests, easy- and hard-way bent coil-turns at various radii, straight and helical samples in up to 31...
March 2017: Superconductor Science & Technology
https://www.readbyqxmd.com/read/28349978/patient-selection-for-prostate-focal-therapy-in-the-era-of-active-surveillance-an-international-delphi-consensus-project
#9
K J Tay, M J Scheltema, H U Ahmed, E Barret, J A Coleman, J Dominguez-Escrig, S Ghai, J Huang, J S Jones, L H Klotz, C N Robertson, R Sanchez-Salas, S Scionti, A Sivaraman, J de la Rosette, T J Polascik
BACKGROUND: Whole-gland extirpation or irradiation is considered the gold standard for curative oncological treatment for localized prostate cancer, but is often associated with sexual and urinary impairment that adversely affects quality of life. This has led to increased interest in developing therapies with effective cancer control but less morbidity. We aimed to provide details of physician consensus on patient selection for prostate focal therapy (FT) in the era of contemporary prostate cancer management...
March 28, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28323604/why-it-s-unjust-to-expect-location-specific-language-specific-or-population-specific-service-from-students-with-underrepresented-minority-or-low-income-backgrounds
#10
Barret Michalec, Maria Athina Tina Martimianakis, Jon C Tilburt, Frederic W Hafferty
In this case we meet Amanda, a medical student of Native and Latin American ethnicity who receives financial aid. Her friends are surprised by her interest in an elite residency program. They suggest, rather, that with her language skills, ethnic background, and interest in social justice, she has a responsibility to work with underserved patient populations. In our commentary, we consider issues raised by the case and explore Amanda's friends' underlying expectations and assumptions that perpetuate the very inequities that the resolution of the case purports to address...
March 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28255592/health-professions-students-perceptions-of-their-ipe-program-potential-barriers-to-student-engagement-with-ipe-goals
#11
Barret Michalec, Carolyn Giordano, Brandie Pugh, Christine Arenson, Elizabeth Speakman
BACKGROUND: Extensive evaluative efforts are underway to explore nuances of interprofessional education (IPE). Few studies, however, have utilized methodology that includes multiple interviews with students of various health disciplines, thereby potentially concealing factors that may be impacting students' attitudes and perceptions of IPE. By focusing on the students' perspectives, this case study explores potential barriers and facilitators to students' engagement with their IPE program...
2017: Journal of Allied Health
https://www.readbyqxmd.com/read/28243789/surgical-method-influences-specimen-margins-and-biochemical-recurrence-during-radical-prostatectomy-for-high-risk-prostate-cancer-a-systematic-review-and-meta-analysis
#12
REVIEW
Victor Srougi, Jose Bessa, Mohammed Baghdadi, Igor Nunes-Silva, Jose Batista da Costa, Silvia Garcia-Barreras, Eric Barret, Francois Rozet, Marc Galiano, Rafael Sanchez-Salas, Xavier Cathelineau
PURPOSE: To perform a meta-analysis comparing the rates of positive surgical margins (PSM) and biochemical recurrence (BCR) between open radical prostatectomy (ORP) and robot-assisted radical prostatectomy (RARP) in patients with high-risk prostate cancer. METHODS: A systematic review was performed on Pubmed, Embase and Scopus databases in August 2016, according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement. References retrieved were evaluated using the Newcastle-Ottawa scale and the Black and Down's tool for quality assessment...
February 27, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28243615/dataset-on-absorption-spectra-and-bulb-concentration-of-phenolic-compounds-that-may-interfere-with-onion-pyruvate-determinations
#13
Vanesa H Beretta, Florencia Bannoud, Marina Insani, Claudio R Galmarini, Pablo F Cavagnaro
We present data on absorption spectra (400-540 nm) and concentration of phenolic compounds quercetin, myricetin, kaempferol, rutin, catechin, epicatechin gallate (ECG) and epigallocatechin gallate (EGCG), in yellow, red and white onions. These data are related to the article entitled "Variability in spectrophotometric pyruvate analyses for predicting onion pungency and nutraceutical value" (Beretta et al., 2017) [1]. Given the relevance of pyruvate determinations for estimating onion pungency and functional value, it is important to identify compounds that can interfere with pyruvate determinations when using two previously published analytical procedures, namely Schwimmer and Weston (1961) (SW) [2] and Anthon and Barret (2002) (AB) [3], which are based on spectrophotometry and light-absorbance at 420 nm and 515 nm, respectively...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28228439/loss-of-pollen-specific-phospholipase-not-like-dad-triggers-gynogenesis-in-maize
#14
Laurine M Gilles, Abdelsabour Khaled, Jean-Baptiste Laffaire, Sandrine Chaignon, Ghislaine Gendrot, Jérôme Laplaige, Hélène Bergès, Genséric Beydon, Vincent Bayle, Pierre Barret, Jordi Comadran, Jean-Pierre Martinant, Peter M Rogowsky, Thomas Widiez
Gynogenesis is an asexual mode of reproduction common to animals and plants, in which stimuli from the sperm cell trigger the development of the unfertilized egg cell into a haploid embryo. Fine mapping restricted a major maize QTL (quantitative trait locus) responsible for the aptitude of inducer lines to trigger gynogenesis to a zone containing a single gene NOT LIKE DAD (NLD) coding for a patatin-like phospholipase A. In all surveyed inducer lines, NLD carries a 4-bp insertion leading to a predicted truncated protein...
March 15, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28214412/histiocytoses-emerging-neoplasia-behind-inflammation
#15
REVIEW
Julien Haroche, Fleur Cohen-Aubart, Barret J Rollins, Jean Donadieu, Frédéric Charlotte, Ahmed Idbaih, Augusto Vaglio, Omar Abdel-Wahab, Jean-François Emile, Zahir Amoura
Histiocytoses are disorders characterised by inflammation and the accumulation of cells derived from the monocyte and macrophage lineages, which results in tissue damage. Although they are often considered rare disorders with protean clinical manifestations, considerable advances in the understanding of their genetics have led to increased clinical recognition of these conditions, and fuelled further insights into their pathogenesis. In this Review, we describe insights into the cells of origin, molecular pathology, clinical features, and treatment strategies for some of the most common histiocytic disorders, including Langerhans cell histiocytosis, Erdheim-Chester disease, and Rosai-Dorfman disease...
February 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28202265/association-between-chronic-exposure-to-air-pollution-and-mortality-in-the-acute-respiratory-distress-syndrome
#16
Barret Rush, Robert C McDermid, Leo Anthony Celi, Keith R Walley, James A Russell, John H Boyd
The impact of chronic exposure to air pollution and outcomes in the acute respiratory distress syndrome (ARDS) is unknown. The Nationwide Inpatient Sample (NIS) from 2011 was utilized for this analysis. The NIS is a national database that captures 20% of all US in-patient hospitalizations from 47 states. Patients with ARDS who underwent mechanical ventilation from the highest 15 ozone pollution cities were compared with the rest of the country. Secondary analyses assessed outcomes of ARDS patients for ozone pollution and particulate matter pollution on a continuous scale by county of residence...
February 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28178046/acute-respiratory-distress-syndrome-in-pregnant-women
#17
Barret Rush, Pawel Martinka, Brett Kilb, Robert C McDermid, John H Boyd, Leo Anthony Celi
OBJECTIVE: To estimate the rate of acute respiratory distress syndrome (ARDS) in pregnant patients as well as to investigate clinical conditions associated with mortality. METHODS: We used the Nationwide Inpatient Sample from 2006 to 2012 to identify a cohort of pregnant patients who underwent mechanical ventilation for ARDS. A multivariate model predicting in-hospital mortality was created. RESULTS: A total of 55,208,382 hospitalizations from the 2006-2012 Nationwide Inpatient Samples were analyzed...
March 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28172843/p471-efficacy-and-safety-of-switching-from-reference-infliximab-to-biosimilar-infliximab-in-patients-with-inflammatory-bowel-disease-first-french-experience
#18
P-A Soret, C Prieux-Klotz, J Avouac, A Molto, M Dior, B Brieau, J Dreanic, M Camus, M Barret, R Coriat, O Conort, F Chast, C Goulvestre, C Le Jeunne, M Dougados, S Nahon, S Chaussade, V Abitbol
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28159256/variability-in-spectrophotometric-pyruvate-analyses-for-predicting-onion-pungency-and-nutraceutical-value
#19
Vanesa H Beretta, Florencia Bannoud, Marina Insani, Claudio R Galmarini, Pablo F Cavagnaro
Onion pyruvate concentration is used as a predictor of flavor intensity and nutraceutical value. The protocol of Schwimmer and Weston (SW) (1961) is the most widespread methodology for estimating onion pyruvate. Anthon and Barret (AB) (2003) proposed modifications to this procedure. Here, we compared these spectrophotometry-based procedures for pyruvate analysis using a diverse collection of onion cultivars. The SW method always led to over-estimation of pyruvate levels in colored, but not in white onions, by up to 65%...
June 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28144947/comparative-primate-obstetrics-observations-of-15-diurnal-births-in-wild-gelada-monkeys-theropithecus-gelada-and-their-implications-for-understanding-human-and-nonhuman-primate-birth-evolution
#20
Nga Nguyen, Laura M Lee, Peter J Fashing, Niina O Nurmi, Kathrine M Stewart, Taylor J Turner, Tyler S Barry, Kadie R Callingham, C Barret Goodale, Bryce S Kellogg, Ryan J Burke, Emily K Bechtold, Megan J Claase, G Anita Eriksen, Sorrel C Z Jones, Jeffrey T Kerby, Jacob B Kraus, Carrie M Miller, Thomas H Trew, Yi Zhao, Evan C Beierschmitt, Malcolm S Ramsay, Jason D Reynolds, Vivek V Venkataraman
OBJECTIVES: The birth process has been studied extensively in many human societies, yet little is known about this essential life history event in other primates. Here, we provide the most detailed account of behaviors surrounding birth for any wild nonhuman primate to date. MATERIALS AND METHODS: Over a recent ∼10-year period, we directly observed 15 diurnal births (13 live births and 2 stillbirths) among geladas (Theropithecus gelada) at Guassa, Ethiopia. During each birth, we recorded the occurrence (or absence) of 16 periparturitional events, chosen for their potential to provide comparative evolutionary insights into the factors that shaped birth behaviors in humans and other primates...
May 2017: American Journal of Physical Anthropology
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