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https://www.readbyqxmd.com/read/29337803/from-big-data-to-artificial-intelligence-harnessing-data-routinely-collected-in-the-process-of-care
#1
Barret Rush, David J Stone, Leo Anthony Celi
No abstract text is available yet for this article.
February 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29302793/complete-genomic-sequence-of-raphanus-sativus-cryptic-virus-4-rscv4-a-novel-alphapartitivirus-from-radish
#2
Laurence Svanella-Dumas, Sébastien Theil, Matthieu Barret, Thierry Candresse
The present work reports the discovery and complete genome sequencing of a virus from symptomless radish seedlings, classifiable as a novel member of the genus Alphapartitivirus, family Partitiviridae. Total RNA extracted from germinating seedlings was sequenced using Illumina technology. Bioinformatic analysis of the RNA-seq data revealed two contigs representing the near full-length genomic sequences of two genomic RNAs representing a new virus. Analysis of the genome sequence (excluding the polyA tail, RNA1: 1976 nt and RNA2: 1751 nt, respectively) showed a genomic organization typical of viruses classed within the Partitiviridae, with each genomic RNA encoding a single open reading frame (ORF)...
January 4, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29288071/design-and-synthesis-of-a-potent-highly-selective-orally-bioavailable-retinoic-acid-receptor-alpha-agonist
#3
Earl Clarke, Christopher I Jarvis, Maria B Goncalves, S Barret Kalindjian, David R Adams, Jane T Brown, Jason J Shiers, David M A Taddei, Elodie Ravier, Stephanie Barlow, Iain Miller, Vanessa Smith, Alan D Borthwick, Jonathan P T Corcoran
A ligand-based virtual screening exercise examining likely bioactive conformations of AM 580 (2) and AGN 193836 (3) was used to identify the novel, less lipophilic RARα agonist 4-(3,5-dichloro-4-ethoxybenzamido)benzoic acid 5, which has good selectivity over the RARβ, and RARγ receptors. Analysis of the medicinal chemistry parameters of the 3,5-substituents of derivatives of template 5 enabled us to design a class of drug-like molecules with lower intrinsic clearance and higher oral bioavailability which led to the novel RARα agonist 4-(3-chloro-4-ethoxy-5-isopropoxybenzamido)-2-methylbenzoic acid 56 that has high RARα potency and excellent selectivity versus RARβ (2 orders of magnitude) and RARγ (4 orders of magnitude) at both the human and mouse RAR receptors with improved drug-like properties...
December 9, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29286736/j-%C3%AF-elliptic-flow-in-pb-pb-collisions-at-sqrt-s_-nn-5-02%C3%A2-%C3%A2-tev
#4
S Acharya, D Adamová, J Adolfsson, M M Aggarwal, G Aglieri Rinella, M Agnello, N Agrawal, Z Ahammed, S U Ahn, S Aiola, A Akindinov, M Al-Turany, S N Alam, D S D Albuquerque, D Aleksandrov, B Alessandro, R Alfaro Molina, Y Ali, A Alici, A Alkin, J Alme, T Alt, L Altenkamper, I Altsybeev, C Alves Garcia Prado, C Andrei, D Andreou, H A Andrews, A Andronic, V Anguelov, C Anson, T Antičić, F Antinori, P Antonioli, R Anwar, L Aphecetche, H Appelshäuser, S Arcelli, R Arnaldi, O W Arnold, I C Arsene, M Arslandok, B Audurier, A Augustinus, R Averbeck, M D Azmi, A Badalà, Y W Baek, S Bagnasco, R Bailhache, R Bala, A Baldisseri, M Ball, R C Baral, A M Barbano, R Barbera, F Barile, L Barioglio, G G Barnaföldi, L S Barnby, V Barret, P Bartalini, K Barth, E Bartsch, N Bastid, S Basu, G Batigne, B Batyunya, P C Batzing, J L Bazo Alba, I G Bearden, H Beck, C Bedda, N K Behera, I Belikov, F Bellini, H Bello Martinez, R Bellwied, L G E Beltran, V Belyaev, G Bencedi, S Beole, A Bercuci, Y Berdnikov, D Berenyi, R A Bertens, D Berzano, L Betev, A Bhasin, I R Bhat, B Bhattacharjee, J Bhom, A Bianchi, L Bianchi, N Bianchi, C Bianchin, J Bielčík, J Bielčíková, A Bilandzic, G Biro, R Biswas, S Biswas, J T Blair, D Blau, C Blume, G Boca, F Bock, A Bogdanov, L Boldizsár, M Bombara, G Bonomi, M Bonora, J Book, H Borel, A Borissov, M Borri, E Botta, C Bourjau, L Bratrud, P Braun-Munzinger, M Bregant, T A Broker, M Broz, E J Brucken, E Bruna, G E Bruno, D Budnikov, H Buesching, S Bufalino, P Buhler, P Buncic, O Busch, Z Buthelezi, J B Butt, J T Buxton, J Cabala, D Caffarri, H Caines, A Caliva, E Calvo Villar, P Camerini, A A Capon, F Carena, W Carena, F Carnesecchi, J Castillo Castellanos, A J Castro, E A R Casula, C Ceballos Sanchez, S Chandra, B Chang, W Chang, S Chapeland, M Chartier, S Chattopadhyay, S Chattopadhyay, A Chauvin, C Cheshkov, B Cheynis, V Chibante Barroso, D D Chinellato, S Cho, P Chochula, M Chojnacki, S Choudhury, T Chowdhury, P Christakoglou, C H Christensen, P Christiansen, T Chujo, S U Chung, C Cicalo, L Cifarelli, F Cindolo, J Cleymans, F Colamaria, D Colella, A Collu, M Colocci, M Concas, G Conesa Balbastre, Z Conesa Del Valle, J G Contreras, T M Cormier, Y Corrales Morales, I Cortés Maldonado, P Cortese, M R Cosentino, F Costa, S Costanza, J Crkovská, P Crochet, E Cuautle, L Cunqueiro, T Dahms, A Dainese, M C Danisch, A Danu, D Das, I Das, S Das, A Dash, S Dash, S De, A De Caro, G de Cataldo, C de Conti, J de Cuveland, A De Falco, D De Gruttola, N De Marco, S De Pasquale, R D De Souza, H F Degenhardt, A Deisting, A Deloff, C Deplano, P Dhankher, D Di Bari, A Di Mauro, P Di Nezza, B Di Ruzza, M A Diaz Corchero, T Dietel, P Dillenseger, Y Ding, R Divià, Ø Djuvsland, A Dobrin, D Domenicis Gimenez, B Dönigus, O Dordic, L V R Doremalen, A K Dubey, A Dubla, L Ducroux, S Dudi, A K Duggal, M Dukhishyam, P Dupieux, R J Ehlers, D Elia, E Endress, H Engel, E Epple, B Erazmus, F Erhardt, B Espagnon, G Eulisse, J Eum, D Evans, S Evdokimov, L Fabbietti, J Faivre, A Fantoni, M Fasel, L Feldkamp, A Feliciello, G Feofilov, A Fernández Téllez, E G Ferreiro, A Ferretti, A Festanti, V J G Feuillard, J Figiel, M A S Figueredo, S Filchagin, D Finogeev, F M Fionda, M Floris, S Foertsch, P Foka, S Fokin, E Fragiacomo, A Francescon, A Francisco, U Frankenfeld, G G Fronze, U Fuchs, C Furget, A Furs, M Fusco Girard, J J Gaardhøje, M Gagliardi, A M Gago, K Gajdosova, M Gallio, C D Galvan, P Ganoti, C Garabatos, E Garcia-Solis, K Garg, C Gargiulo, P Gasik, E F Gauger, M B Gay Ducati, M Germain, J Ghosh, P Ghosh, S K Ghosh, P Gianotti, P Giubellino, P Giubilato, E Gladysz-Dziadus, P Glässel, D M Goméz Coral, A Gomez Ramirez, A S Gonzalez, V Gonzalez, P González-Zamora, S Gorbunov, L Görlich, S Gotovac, V Grabski, L K Graczykowski, K L Graham, L Greiner, A Grelli, C Grigoras, V Grigoriev, A Grigoryan, S Grigoryan, J M Gronefeld, F Grosa, J F Grosse-Oetringhaus, R Grosso, F Guber, R Guernane, B Guerzoni, K Gulbrandsen, T Gunji, A Gupta, R Gupta, I B Guzman, R Haake, C Hadjidakis, H Hamagaki, G Hamar, J C Hamon, M R Haque, J W Harris, A Harton, H Hassan, D Hatzifotiadou, S Hayashi, S T Heckel, E Hellbär, H Helstrup, A Herghelegiu, E G Hernandez, G Herrera Corral, F Herrmann, B A Hess, K F Hetland, H Hillemanns, C Hills, B Hippolyte, B Hohlweger, D Horak, S Hornung, R Hosokawa, P Hristov, C Hughes, T J Humanic, N Hussain, T Hussain, D Hutter, D S Hwang, S A Iga Buitron, R Ilkaev, M Inaba, M Ippolitov, M S Islam, M Ivanov, V Ivanov, V Izucheev, B Jacak, N Jacazio, P M Jacobs, M B Jadhav, S Jadlovska, J Jadlovsky, S Jaelani, C Jahnke, M J Jakubowska, M A Janik, P H S Y Jayarathna, C Jena, M Jercic, R T Jimenez Bustamante, P G Jones, A Jusko, P Kalinak, A Kalweit, J H Kang, V Kaplin, S Kar, A Karasu Uysal, O Karavichev, T Karavicheva, L Karayan, P Karczmarczyk, E Karpechev, U Kebschull, R Keidel, D L D Keijdener, M Keil, B Ketzer, Z Khabanova, P Khan, S A Khan, A Khanzadeev, Y Kharlov, A Khatun, A Khuntia, M M Kielbowicz, B Kileng, B Kim, D Kim, D J Kim, H Kim, J S Kim, J Kim, M Kim, S Kim, T Kim, S Kirsch, I Kisel, S Kiselev, A Kisiel, G Kiss, J L Klay, C Klein, J Klein, C Klein-Bösing, S Klewin, A Kluge, M L Knichel, A G Knospe, C Kobdaj, M Kofarago, M K Köhler, T Kollegger, V Kondratiev, N Kondratyeva, E Kondratyuk, A Konevskikh, M Konyushikhin, M Kopcik, M Kour, C Kouzinopoulos, O Kovalenko, V Kovalenko, M Kowalski, G Koyithatta Meethaleveedu, I Králik, A Kravčáková, L Kreis, M Krivda, F Krizek, E Kryshen, M Krzewicki, A M Kubera, V Kučera, C Kuhn, P G Kuijer, A Kumar, J Kumar, L Kumar, S Kumar, S Kundu, P Kurashvili, A Kurepin, A B Kurepin, A Kuryakin, S Kushpil, M J Kweon, Y Kwon, S L La Pointe, P La Rocca, C Lagana Fernandes, Y S Lai, I Lakomov, R Langoy, K Lapidus, C Lara, A Lardeux, A Lattuca, E Laudi, R Lavicka, R Lea, L Leardini, S Lee, F Lehas, S Lehner, J Lehrbach, R C Lemmon, E Leogrande, I León Monzón, P Lévai, X Li, J Lien, R Lietava, B Lim, S Lindal, V Lindenstruth, S W Lindsay, C Lippmann, M A Lisa, V Litichevskyi, W J Llope, D F Lodato, P I Loenne, V Loginov, C Loizides, P Loncar, X Lopez, E López Torres, A Lowe, P Luettig, J R Luhder, M Lunardon, G Luparello, M Lupi, T H Lutz, A Maevskaya, M Mager, S M Mahmood, A Maire, R D Majka, M Malaev, L Malinina, D Mal'Kevich, P Malzacher, A Mamonov, V Manko, F Manso, V Manzari, Y Mao, M Marchisone, J Mareš, G V Margagliotti, A Margotti, J Margutti, A Marín, C Markert, M Marquard, N A Martin, P Martinengo, J A L Martinez, M I Martínez, G Martínez García, M Martinez Pedreira, S Masciocchi, M Masera, A Masoni, E Masson, A Mastroserio, A M Mathis, P F T Matuoka, A Matyja, C Mayer, J Mazer, M Mazzilli, M A Mazzoni, F Meddi, Y Melikyan, A Menchaca-Rocha, E Meninno, J Mercado Pérez, M Meres, S Mhlanga, Y Miake, M M Mieskolainen, D L Mihaylov, K Mikhaylov, A Mischke, A N Mishra, D Miśkowiec, J Mitra, C M Mitu, N Mohammadi, A P Mohanty, B Mohanty, M Mohisin Khan, E Montes, D A Moreira De Godoy, L A P Moreno, S Moretto, A Morreale, A Morsch, V Muccifora, E Mudnic, D Mühlheim, S Muhuri, M Mukherjee, J D Mulligan, M G Munhoz, K Münning, R H Munzer, H Murakami, S Murray, L Musa, J Musinsky, C J Myers, J W Myrcha, D Nag, B Naik, R Nair, B K Nandi, R Nania, E Nappi, A Narayan, M U Naru, H Natal da Luz, C Nattrass, S R Navarro, K Nayak, R Nayak, T K Nayak, S Nazarenko, R A Negrao De Oliveira, L Nellen, S V Nesbo, F Ng, M Nicassio, M Niculescu, J Niedziela, B S Nielsen, S Nikolaev, S Nikulin, V Nikulin, F Noferini, P Nomokonov, G Nooren, J C C Noris, J Norman, A Nyanin, J Nystrand, H Oeschler, A Ohlson, T Okubo, L Olah, J Oleniacz, A C Oliveira Da Silva, M H Oliver, J Onderwaater, C Oppedisano, R Orava, M Oravec, A Ortiz Velasquez, A Oskarsson, J Otwinowski, K Oyama, Y Pachmayer, V Pacik, D Pagano, G Paić, P Palni, J Pan, A K Pandey, S Panebianco, V Papikyan, P Pareek, J Park, S Parmar, A Passfeld, S P Pathak, R N Patra, B Paul, H Pei, T Peitzmann, X Peng, L G Pereira, H Pereira Da Costa, D Peresunko, E Perez Lezama, V Peskov, Y Pestov, V Petráček, V Petrov, M Petrovici, C Petta, R P Pezzi, S Piano, M Pikna, P Pillot, L O D L Pimentel, O Pinazza, L Pinsky, D B Piyarathna, M Płoskoń, M Planinic, F Pliquett, J Pluta, S Pochybova, P L M Podesta-Lerma, M G Poghosyan, B Polichtchouk, N Poljak, W Poonsawat, A Pop, H Poppenborg, S Porteboeuf-Houssais, V Pozdniakov, S K Prasad, R Preghenella, F Prino, C A Pruneau, I Pshenichnov, M Puccio, V Punin, J Putschke, S Raha, S Rajput, J Rak, A Rakotozafindrabe, L Ramello, F Rami, D B Rana, R Raniwala, S Raniwala, S S Räsänen, B T Rascanu, D Rathee, V Ratza, I Ravasenga, K F Read, K Redlich, A Rehman, P Reichelt, F Reidt, X Ren, R Renfordt, A Reshetin, K Reygers, V Riabov, T Richert, M Richter, P Riedler, W Riegler, F Riggi, C Ristea, M Rodríguez Cahuantzi, K Røed, E Rogochaya, D Rohr, D Röhrich, P S Rokita, F Ronchetti, E D Rosas, P Rosnet, A Rossi, A Rotondi, F Roukoutakis, C Roy, P Roy, A J Rubio Montero, O V Rueda, R Rui, B Rumyantsev, A Rustamov, E Ryabinkin, Y Ryabov, A Rybicki, S Saarinen, S Sadhu, S Sadovsky, K Šafařík, S K Saha, B Sahlmuller, B Sahoo, P Sahoo, R Sahoo, S Sahoo, P K Sahu, J Saini, S Sakai, M A Saleh, J Salzwedel, S Sambyal, V Samsonov, A Sandoval, A Sarkar, D Sarkar, N Sarkar, P Sarma, M H P Sas, E Scapparone, F Scarlassara, B Schaefer, H S Scheid, C Schiaua, R Schicker, C Schmidt, H R Schmidt, M O Schmidt, M Schmidt, N V Schmidt, J Schukraft, Y Schutz, K Schwarz, K Schweda, G Scioli, E Scomparin, M Šefčík, J E Seger, Y Sekiguchi, D Sekihata, I Selyuzhenkov, K Senosi, S Senyukov, E Serradilla, P Sett, A Sevcenco, A Shabanov, A Shabetai, R Shahoyan, W Shaikh, A Shangaraev, A Sharma, A Sharma, M Sharma, M Sharma, N Sharma, A I Sheikh, K Shigaki, S Shirinkin, Q Shou, K Shtejer, Y Sibiriak, S Siddhanta, K M Sielewicz, T Siemiarczuk, S Silaeva, D Silvermyr, G Simatovic, G Simonetti, R Singaraju, R Singh, V Singhal, T Sinha, B Sitar, M Sitta, T B Skaali, M Slupecki, N Smirnov, R J M Snellings, T W Snellman, J Song, M Song, F Soramel, S Sorensen, F Sozzi, I Sputowska, J Stachel, I Stan, P Stankus, E Stenlund, D Stocco, M M Storetvedt, P Strmen, A A P Suaide, T Sugitate, C Suire, M Suleymanov, M Suljic, R Sultanov, M Šumbera, S Sumowidagdo, K Suzuki, S Swain, A Szabo, I Szarka, U Tabassam, J Takahashi, G J Tambave, N Tanaka, M Tarhini, M Tariq, M G Tarzila, A Tauro, G Tejeda Muñoz, A Telesca, K Terasaki, C Terrevoli, B Teyssier, D Thakur, S Thakur, D Thomas, F Thoresen, R Tieulent, A Tikhonov, A R Timmins, A Toia, M Toppi, S R Torres, S Tripathy, S Trogolo, G Trombetta, L Tropp, V Trubnikov, W H Trzaska, B A Trzeciak, T Tsuji, A Tumkin, R Turrisi, T S Tveter, K Ullaland, E N Umaka, A Uras, G L Usai, A Utrobicic, M Vala, J Van Der Maarel, J W Van Hoorne, M van Leeuwen, T Vanat, P Vande Vyvre, D Varga, A Vargas, M Vargyas, R Varma, M Vasileiou, A Vasiliev, A Vauthier, O Vázquez Doce, V Vechernin, A M Veen, A Velure, E Vercellin, S Vergara Limón, R Vernet, R Vértesi, L Vickovic, S Vigolo, J Viinikainen, Z Vilakazi, O Villalobos Baillie, A Villatoro Tello, A Vinogradov, L Vinogradov, T Virgili, V Vislavicius, A Vodopyanov, M A Völkl, K Voloshin, S A Voloshin, G Volpe, B von Haller, I Vorobyev, D Voscek, D Vranic, J Vrláková, B Wagner, H Wang, M Wang, D Watanabe, Y Watanabe, M Weber, S G Weber, D F Weiser, S C Wenzel, J P Wessels, U Westerhoff, A M Whitehead, J Wiechula, J Wikne, G Wilk, J Wilkinson, G A Willems, M C S Williams, E Willsher, B Windelband, W E Witt, R Xu, S Yalcin, K Yamakawa, P Yang, S Yano, Z Yin, H Yokoyama, I-K Yoo, J H Yoon, E Yun, V Yurchenko, V Zaccolo, A Zaman, C Zampolli, H J C Zanoli, N Zardoshti, A Zarochentsev, P Závada, N Zaviyalov, H Zbroszczyk, M Zhalov, H Zhang, X Zhang, Y Zhang, C Zhang, Z Zhang, C Zhao, N Zhigareva, D Zhou, Y Zhou, Z Zhou, H Zhu, J Zhu, Y Zhu, A Zichichi, M B Zimmermann, G Zinovjev, J Zmeskal, S Zou
We report a precise measurement of the J/ψ elliptic flow in Pb-Pb collisions at sqrt[s_{NN}]=5.02  TeV with the ALICE detector at the LHC. The J/ψ mesons are reconstructed at midrapidity (|y|<0.9) in the dielectron decay channel and at forward rapidity (2.5<y<4.0) in the dimuon channel, both down to zero transverse momentum. At forward rapidity, the elliptic flow v_{2} of the J/ψ is studied as a function of the transverse momentum and centrality. A positive v_{2} is observed in the transverse momentum range 2<p_{T}<8  GeV/c in the three centrality classes studied and confirms with higher statistics our earlier results at sqrt[s_{NN}]=2...
December 15, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29245952/the-humanized-anti-human-amhrii-mab-3c23k-exerts-an-anti-tumor-activity-against-human-ovarian-cancer-through-tumor-associated-macrophages
#5
Houcine Bougherara, Fariba Némati, André Nicolas, Gérald Massonnet, Martine Pugnière, Charlotte Ngô, Marie-Aude Le Frère-Belda, Alexandra Leary, Jérôme Alexandre, Didier Meseure, Jean-Marc Barret, Isabelle Navarro-Teulon, André Pèlegrin, Sergio Roman-Roman, Jean-François Prost, Emmanuel Donnadieu, Didier Decaudin
Müllerian inhibiting substance, also called anti-Müllerian hormone (AMH), inhibits proliferation and induces apoptosis of AMH type II receptor-positive tumor cells, such as human ovarian cancers (OCs). On this basis, a humanized glyco-engineered monoclonal antibody (3C23K) has been developed. The aim of this study was therefore to experimentally confirm the therapeutic potential of 3C23K in human OCs. We first determined by immunofluorescence, immunohistochemistry and cytofluorometry analyses the expression of AMHRII in patient's tumors and found that a majority (60 to 80% depending on the detection technique) of OCs were positive for this marker...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29243074/predictive-factors-and-the-important-role-of-detectable-prostate-specific-antigen-for-detection-of-clinical-recurrence-and-cancer-specific-mortality-following-robot-assisted-radical-prostatectomy
#6
S García-Barreras, F Rozet, I Nunes-Silva, V Srougi, R Sanchez-Salas, E Barret, M Galiano, X Cathelineau
PURPOSE: To evaluate predictive factors associated with detectable prostate-specific antigen (PSA) and describe clinical recurrence (CR) and cancer-specific mortality (CSM) after robot-assisted radical prostatectomy (RARP). METHODS: The study included 2500 patients who were treated with RARP at a single institution between 2000 and 2016. All patients had clinically localized PCa. Patients were divided into two groups according to PSA value at 6 weeks after surgery: undetectable (n = 2271; PSA < 0...
December 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29239850/small-bowel-capsule-endoscopy-may-we-delegate-it-to-nurses
#7
Johann Dreanic, Maximilien Barret, Marion Dhooge, Marianne Gaudric, Sarah Leblanc, Vered Abitbol, Frederic Prat, Stanislas Chaussade, Romain Coriat
AIM: Small bowel capsule endoscopy (CE) is a non-invasive and validated technique allowing the visualization of the small intestine mucosa. It generated more than 40,000 images per examination and induced a long median time of medical reading that may exceed 1 hour. In a transfer of skills' program, the CE reading might be transferred to nurses. We herein evaluate and present a feasibility study of the CE to nurses. METHODS: Nurses experienced in endoscopy were trained for small bowel CE reading, selection and interpretation of pathological images...
November 24, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29223469/oncological-and-functional-outcomes-of-elderly-men-treated-with-hifu-vs-minimally-invasive-radical-prostatectomy-a-propensity-score-analysis
#8
Paolo Capogrosso, Eric Barret, Rafael Sanchez-Salas, Igor Nunes-Silva, François Rozet, Marc Galiano, Eugenio Ventimiglia, Alberto Briganti, Andrea Salonia, Francesco Montorsi, Xavier Cathelineau
AIM: To assess outcomes of whole gland high-intensity focused ultrasound (HIFU) as compared with minimally-invasive radical prostatectomy (MIRP) in elderly patients. MATERIALS & METHODS: Patients aged ≥70 years with, cT1-cT2 disease, biopsy Gleason score (GS) 3 + 3 or 3 + 4 and preoperative PSA ≤10 ng/mL were submitted to either whole-gland HIFU or MIRP. Propensity-score matching analysis was performed to ensure the baseline equivalence of groups. Follow-up visits were routinely performed assessing PSA and urinary function according to the International Continence Score (ICS) and the International Prostatic Symptoms Score (IPSS) questionnaires...
December 1, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29215496/comparing-health-related-quality-of-life-outcomes-in-patients-undergoing-either-primary-or-revision-anterior-cervical-discectomy-and-fusion
#9
Gregory D Schroeder, Barrett S Boody, Christopher K Kepler, Mark F Kurd, Stephen Silva, Kristen Nicholson, Jefferson R Wilson, Barret I Woods, Kris E Radcliff, D Greg Anderson, Alan S Hilibrand, Alexander R Vaccaro, Jeffery A Rihn
STUDY DESIGN: A retrospective review of prospectively collected data. OBJECTIVE: Compare HRQOL outcome metrics in patients undergoing primary and revision ACDF. SUMMARY OF BACKGROUND DATA: Anterior cervical discectomy and fusion (ACDF) is associated with significant improvements in health related quality of life (HRQOL) outcome metrics. However, 2.9% of patients per year will develop symptomatic adjacent segment disease and there is a paucity of literature on HRQOL outcomes following revision ACDF...
December 5, 2017: Spine
https://www.readbyqxmd.com/read/29205431/anatomic-delineation-of-tarsal-tunnel-innervation-via-ultrasonography
#10
Alvaro Iborra, Manuel Villanueva, Stephen L Barrett, Edgardo Rodriguez-Collazo, Pablo Sanz
OBJECTIVES: High-resolution ultrasonography (US) can play an important role in studying nerves, as it has several advantages. Entrapments of distal tibial nerve branches can be mapped out or diagnosed with selective anesthetic blocks, and US can guide therapeutic procedures, such as radiofrequency ablation and selective infiltrations of specific nerve branches. The aim of this study was to verify that US is an effective method for accurately locating the posterior tibial nerve and its terminal branches, such as the medial calcaneal branch, the first calcaneal branch, and the medial and lateral plantar nerves...
December 4, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29178446/experimental-and-theoretical-study-of-enhanced-photocatalytic-activity-of-mg-doped-zno-nps-and-zno-rgo-nanocomposites
#11
Ramin Yousefi, Javad Beheshtian, Seyedeh Mozhgan Seyed-Talebi, H R Azimi, Farid Jamali-Sheini
A systematic experimental and theoretical study of the origin of the enhanced photocatalytic performance of Mg-doped ZnO nanoparticles (NPs) and Mg-doped ZnO/reduced-graphene-oxide (rGO) nanocomposites were investigated. In addition to Mg, Cd was chosen as a doping material for band-gap engineering of ZnO NPs, which its effects were compared with that of Mg concerning the photocatalytic performance of ZnO nanostructures. Experimental results showed that Mg, as a doping material, recognizably ameliorated the photocatalytic performance of ZnO NPs and ZnO/graphene nanocomposites...
November 27, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29177211/functional-rehabilitation-in-advanced-intraoral-cancer
#12
Juan P Barret, Jan L Roodenburg
Modern treatment of advanced intraoral cancer involves multidisciplinary teams with use of complicated reconstructive techniques to provide improved survival with optimal rehabilitation. Mastication is an important part of this process, and it can be severely impaired by tumor ablation. Whether flap reconstruction is a determinant factor in dental rehabilitation is still in debate. Patients and methods: Thirty-five patients with advanced intraoral cancer were reviewed to determine dental rehabilitation of different reconstructive techniques...
February 2017: International Journal of Surgery. Oncology
https://www.readbyqxmd.com/read/29169194/intraductal-radiofrequency-ablation-of-an-intraductal-papillary-mucinous-neoplasia-of-the-main-pancreatic-duct
#13
Diane Lorenzo, Maximilien Barret, Benoit Bordacahar, Sarah Leblanc, Stanislas Chaussade, Pierre Cattan, Frédéric Prat
No abstract text is available yet for this article.
November 23, 2017: Endoscopy
https://www.readbyqxmd.com/read/29162378/arthroscopic-medial-meniscal-repair-with-or-without-concurrent-anterior-cruciate-ligament-reconstruction-a-subgroup-analysis
#14
Erdal Uzun, Abdulhamit Misir, Turan Bilge Kizkapan, Mustafa Ozcamdalli, Soner Akkurt, Ahmet Guney
BACKGROUND: There are few large-scale, long-term studies comparing medial meniscal repairs with or without concurrent anterior cruciate ligament (ACL) reconstruction. METHODS: A total of 140 patients who underwent arthroscopic medial meniscal repair were divided into two groups: Group A, meniscus repair only and Group B, meniscus repair with concurrent ACL reconstruction. Clinical assessments in- cluded physical examination findings, Lysholm score, and the International Knee Documentation Committee (IKDC) form...
November 18, 2017: Knee
https://www.readbyqxmd.com/read/29149941/pathophysiology-of-septic-shock
#15
REVIEW
James A Russell, Barret Rush, John Boyd
Fundamental features of septic shock are vasodilation, increased permeability, hypovolemia, and ventricular dysfunction. Vasodilation owing to increased nitric oxide and prostaglandins is treated with vasopressors (norepinephrine first). Increased permeability relates to several pathways (Slit/Robo4, vascular endothelial growth factor, angiopoietin 1 and 2/Tie2 pathway, sphingosine-1-phosphate, and heparin-binding protein), some of which are targets for therapies. Hypovolemia is common and crystalloid is recommended for fluid resuscitation...
January 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29132919/clonal-replacement-and-expansion-among-invasive-meningococcal-isolates-of-serogroup-w-in-france
#16
Eva Hong, Anne-Sophie Barret, Aude Terrade, Mélanie Denizon, Denise Antona, Myriam Aouiti-Trabelsi, Ala-Eddine Deghmane, Isabelle Parent du Châtelet, Daniel Levy-Bruhl, Muhamed-Kheir Taha
Background Neisseria meningitidis group W (NmW) belonging to the clonal complex ST-11 (NmW/cc11) spread in Europe and in France in 2000 and declined thereafter. In France, invasive meningococcal disease (IMD) due to NmW increased again in 2012 and thereafter since 2015. Several sub-lineages of NmW/cc11 are circulating worldwide with successive epidemic waves. We aimed to describe recent epidemiological trends of NmW in France and to explore the microbiological and epidemiological characteristics associated with different NmW/cc11 sub-lineages...
November 10, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29068859/racial-and-geographic-disparities-in-interhospital-icu-transfers
#17
Patrick D Tyler, David J Stone, Benjamin P Geisler, Stuart McLennan, Leo Anthony Celi, Barret Rush
OBJECTIVES: Interhospital transfer, a common intervention, may be subject to healthcare disparities. In mechanically ventilated patients with sepsis, we hypothesize that disparities not disease related would be found between patients who were and were not transferred. DESIGN: Retrospective cohort study. SETTING: Nationwide Inpatient Sample, 2006-2012. PATIENTS: Patients over 18 years old with a primary diagnosis of sepsis who underwent mechanical ventilation...
October 24, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29068858/outcomes-of-ventilated-patients-with-sepsis-who-undergo-interhospital-transfer-a-nationwide-linked-analysis
#18
Barret Rush, Patrick D Tyler, David J Stone, Benjamin P Geisler, Keith R Walley, Leo Anthony Celi
OBJECTIVES: The outcomes of critically ill patients who undergo interhospital transfer are not well understood. Physicians assume that patients who undergo interhospital transfer will receive more advanced care that may translate into decreased morbidity or mortality relative to a similar patient who is not transferred. However, there is little empirical evidence to support this assumption. We examined country-level U.S. data from the Nationwide Readmissions Database to examine whether, in mechanically ventilated patients with sepsis, interhospital transfer is associated with a mortality benefit...
October 24, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29045189/effect-of-climatic-variables-on-abundance-and-dispersal-of-lecanosticta-acicola-spores-and-impact-of-defoliation-on-eastern-white-pine
#19
Stephen Wyka, Cameron McIntire, Cheryl Smith, Isabel Munck, Barret Rock, Heidi Asbjornsen, Kirk Broders
The disease complex white pine needle damage (WPND), first reported in 2006, has now escalated to an epidemic state across the northeastern U.S. Although this complex is composed of several fungal species, Lecanosticta acicola is considered to be the primary causal agent. Knowledge regarding the epidemiology, specific climatic factors that affect the spread of L. acicola on eastern white pine (Pinus strobus) in natural forest settings, and the potential risks repeated defoliation may have on tree health is limited...
October 18, 2017: Phytopathology
https://www.readbyqxmd.com/read/29039897/biochemical-recurrence-after-radical-prostatectomy-what-does-it-mean
#20
Rafael Tourinho-Barbosa, Victor Srougi, Igor Nunes-Silva, Mohammed Baghdadi, Gregory Rembeyo, Sophie S Eiffel, Eric Barret, Francois Rozet, Marc Galiano, Xavier Cathelineau, Rafael Sanchez-Salas
BACKGROUND: Radical prostatectomy (RP) has been used as the main primary treatment for prostate cancer (PCa) for many years with excellent oncologic results. However, approximately 20-40% of those patients has failed to RP and presented biochemical recurrence (BCR). Prostatic specific antigen (PSA) has been the pivotal tool for recurrence diagnosis, but there is no consensus about the best PSA threshold to define BCR until this moment. The natural history of BCR after surgical procedure is highly variable, but it is important to distinguish biochemical and clinical recurrence and to find the correct timing to start multimodal treatment strategy...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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