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https://www.readbyqxmd.com/read/28728756/circulating-soluble-urokinase-plasminogen-activator-receptor-levels-and-peripheral-arterial-disease-outcomes
#1
Ayman Samman Tahhan, Salim S Hayek, Pratik Sandesara, Jamal Hajjari, Muhammad Hammadah, Wesley T O'Neal, Heval M Kelli, Ayman Alkhoder, Nima Ghasemzadeh, Yi-An Ko, Hiroshi Aida, Mohamad Mazen Gafeer, Naser Abdelhadi, Kareem Hosny Mohammed, Keyur Patel, Shipra Arya, Jochen Reiser, Viola Vaccarino, Laurence Sperling, Arshed Quyyumi
BACKGROUND AND AIMS: Circulating soluble urokinase plasminogen activator receptor (suPAR) is a marker of immune activation associated with atherosclerosis. Whether suPAR levels are associated with prevalent peripheral arterial disease (PAD) and its adverse outcomes remains unknown and is the aim of the study. METHODS: SuPAR levels were measured in 5810 patients (mean age 63 years, 63% male, 77% with obstructive coronary artery disease [CAD]) undergoing cardiac catheterization...
June 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28713869/association-of-anisocytosis-with-markers-of-immune-activation-and-exhaustion-in-treated-hiv
#2
Sadeer G Al-Kindi, David A Zidar, Grace A McComsey, Chris T Longenecker
BACKGROUND: Treated HIV infection is associated with heightened inflammation which can contribute to increased risk of cardiovascular disease (CVD). We have previously shown that anisocytosis, as measured by red cell distribution width (RDW), is independently associated with prevalent CVD in people living with HIV (PLHIV). In this study, we sought to identify immune correlates of RDW in PLHIV receiving antiretroviral therapy. METHODS: We performed a cross-sectional and longitudinal analysis of 147 virally-suppressed PLHIV, who had LDL < 130 mg/dL and evidence of heightened inflammation, in a randomized trial of statin therapy...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28700299/chronic-health-conditions-and-key-health-indicators-among-lesbian-gay-and-bisexual-older-us-adults-2013-2014
#3
Karen I Fredriksen-Goldsen, Hyun-Jun Kim, Chengshi Shui, Amanda E B Bryan
OBJECTIVES: To examine disparities in chronic conditions and health indicators among lesbian, gay, and bisexual (LGB) adults aged 50 years or older in the United States. METHODS: We used data from the 2013 and 2014 National Health Interview Survey to compare disparities in chronic conditions, health outcomes and behaviors, health care access, and preventive health care by sexual orientation and gender. RESULTS: LGB older adults were significantly more likely than heterosexual older adults to have a weakened immune system and low back or neck pain...
August 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28698603/identification-of-differentially-methylated-brca1-and-crisp2-dna-regions-as-blood-surrogate-markers-for-cardiovascular-disease
#4
Geoffrey Istas, Ken Declerck, Maria Pudenz, Katarzyna Szarc Vel Szic, Veronica Lendinez-Tortajada, Montserrat Leon-Latre, Karen Heyninck, Guy Haegeman, Jose A Casasnovas, Maria Tellez-Plaza, Clarissa Gerhauser, Christian Heiss, Ana Rodriguez-Mateos, Wim Vanden Berghe
Genome-wide Illumina InfiniumMethylation 450 K DNA methylation analysis was performed on blood samples from clinical atherosclerosis patients (n = 8) and healthy donors (n = 8) in the LVAD study (NCT02174133, NCT01799005). Multiple differentially methylated regions (DMR) could be identified in atherosclerosis patients, related to epigenetic control of cell adhesion, chemotaxis, cytoskeletal reorganisations, cell proliferation, cell death, estrogen receptor pathways and phagocytic immune responses...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28683054/invasive-cancer-incidence-2004-2013-and-deaths-2006-2015-in-nonmetropolitan-and-metropolitan-counties-united-states
#5
S Jane Henley, Robert N Anderson, Cheryll C Thomas, Greta M Massetti, Brandy Peaker, Lisa C Richardson
PROBLEM/CONDITION: Previous reports have shown that persons living in nonmetropolitan (rural or urban) areas in the United States have higher death rates from all cancers combined than persons living in metropolitan areas. Disparities might vary by cancer type and between occurrence and death from the disease. This report provides a comprehensive assessment of cancer incidence and deaths by cancer type in nonmetropolitan and metropolitan counties. REPORTING PERIOD: 2004-2015...
July 7, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28675304/immune-markers-diurnal-blood-pressure-profile-and-cardiac-function-in-virologically-suppressed-hiv-infected-patients
#6
Ingjerd W Manner, Bård Waldum-Grevbo, Birgit Nomeland Witczak, Morten Bækken, Olav Øktedalen, Ingrid Os, Thomas Schwartz, Ivar Sjaastad
PURPOSE: Non-dipping nocturnal blood pressure (BP) pattern has been reported prevalent among HIV-infected patients and is associated with adverse cardiovascular outcomes. The aims of this observational study were to identify predictors of nocturnal BP decline, and to explore whether diurnal BP profile is associated with alterations in cardiac structure and function. MATERIALS AND METHODS: A total of 108 treated HIV-infected patients with suppressed viremia underwent ambulatory BP measurement, 51 of these patients also underwent echocardiography...
July 4, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28668304/toll-like-receptor-4-signaling-pathway-in-aorta-aging-and-diseases-its-double-nature
#7
REVIEW
Carmela Rita Balistreri, Giovanni Ruvolo, Domenico Lio, Rosalinda Madonna
Recent advances in the field of innate immunity have revealed a complex role of innate immune signaling pathways in both tissue homeostasis and disease. Among them, the Toll-like receptor 4 (TLR-4) pathways has been linked to various pathophysiological conditions, such as cardiovascular diseases (CVDs). This has been interrogated by developing multiple laboratory tools that have shown in animal models and clinical conditions, the involvement of the TLR-4 signaling pathway in the pathophysiology of different CVDs, such as atherosclerosis, ischemic heart disease, heart failure, ischemia-reperfusion injury and aorta aneurysm...
June 28, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28662159/pre-clinical-carotid-atherosclerosis-and-scd163-among-virally-suppressed-hiv-patients-in-botswana-compared-with-uninfected-controls
#8
Mosepele Mosepele, Linda C Hemphill, Walter Moloi, Sikhulile Moyo, Isaac Nkele, Joseph Makhema, Kara Bennett, Virginia A Triant, Shahin Lockman
OBJECTIVES: Human immune deficiency virus (HIV) is associated with increased cardiovascular disease (CVD) risk, yet the relationship between HIV and carotid atherosclerosis / monocyte activation among virally suppressed HIV-infected patients in sub-Saharan Africa is not well understood. METHODS: We measured traditional CVD risk factors, bilateral distal common carotid intima media thickness (cIMT), presence of carotid plaque and plasma sCD163 levels among virally suppressed HIV-infected adults and HIV-uninfected controls, in a cross-sectional study in Gaborone, Botswana...
2017: PloS One
https://www.readbyqxmd.com/read/28658137/cardiovascular-disease-in-immune-mediated-inflammatory-diseases-a-cross-sectional-analysis-of-6-cohorts
#9
MULTICENTER STUDY
Benjamín Fernández-Gutiérrez, Pedro P Perrotti, Javier P Gisbert, Eugeni Domènech, Antonio Fernández-Nebro, Juan D Cañete, Carlos Ferrándiz, Jesús Tornero, Valle García-Sánchez, Julián Panés, Eduardo Fonseca, Francisco Blanco, Jesús Rodríguez-Moreno, Patricia Carreira, Antonio Julià, Sara Marsal, Luis Rodriguez-Rodriguez
To analyze in several immune-mediated inflammatory diseases (IMIDs) the influence of demographic and clinical-related variables on the prevalence of cardiovascular disease (CVD), and compare their standardized prevalences.Cross-sectional study, including consecutive patients diagnosed with rheumatoid arthritis, psoriatic arthritis, psoriasis, systemic lupus erythematosus, Crohn disease, or ulcerative colitis, from rheumatology, gastroenterology, and dermatology tertiary care outpatient clinics located throughout Spain, between 2007 and 2010...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28652179/non-coding-rna-regulation-of-t-cell-biology-implications-for-age-associated-cardiovascular-diseases
#10
REVIEW
Jose Coelho-Lima, Ioakim Spyridopoulos
Prevalence of age-associated cardiovascular diseases (CVD) has dramatically increased as a result of improvements in life expectancy. Chronic inflammation is a shared pathophysiological feature of age-associated CVDs, indicating a role for the immune system in the onset and development of CVDs. Indeed, ageing elicits profound changes in both the cardiovascular and immune system, especially in the T cell compartment. Although such changes have been well described at the cellular level, the molecular mechanisms underlying immune-mediated cardiovascular ageing remain largely unexplored...
June 23, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28644156/clinical-case-of-the-month-a-57-year-old-man-with-an-axillary-mass
#11
Palak Desai, Andrew Myers, Brian Boulmay, Fred A Lopez
A 57-year-old man presented to the surgical oncology clinic with a mildly tender mass under his right arm. Four years prior, the patient had a melanoma removed from his right shoulder along with an ipsilateral right axillary sentinel lymph sampling. Computed tomography (CT) scan was negative for metastatic disease at that time. The patient did not undergo completion axillary node dissection and was lost to follow-up. The patient was originally from Australia, did not tan but reported multiple sunburns before age 18...
May 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28624868/how-does-cytomegalovirus-factor-into-diseases-of-aging-and-vaccine-responses-and-by-what-mechanisms
#12
REVIEW
Allison E Aiello, Yen-Ling Chiu, Daniela Frasca
Cytomegalovirus (CMV) is an important pathogen for both clinical and population settings. There is a growing body of research implicating CMV in multiple health outcomes across the life course. At the same time, there is mounting evidence that individuals living in poverty are more likely to be exposed to CMV and more likely to experience many of the chronic conditions for which CMV has been implicated. Further research on the causal role of CMV for health and well-being is needed. However, the strong evidence implicating CMV in type 2 diabetes, autoimmunity, cancer, cardiovascular disease, vaccination, and age-related alterations in immune function warrants clinical and public health action...
June 2017: GeroScience
https://www.readbyqxmd.com/read/28616771/androgen-supplementation-improves-some-but-not-all-aspects-of-immune-senescence-in-aged-male-macaques
#13
Maham Rais, Randall M Wilson, Henryk F Urbanski, Ilhem Messaoudi
Aging leads to a progressive decline in immune function commonly referred to as immune senescence, which results in increased incidence and severity of infection. In addition, older males experience a significant disruption in their levels of circulating androgens, notably testosterone and dehydroepiandrosterone (DHEA), which has been linked to sarcopenia, osteoporosis, cardiovascular disease, and diabetes. Since sex steroid levels modulate immune function, it is possible that the age-related decline in androgen levels can also affect immune senescence...
June 14, 2017: GeroScience
https://www.readbyqxmd.com/read/28614056/spermine-and-spermidine-reversed-age-related-cardiac-deterioration-in-rats
#14
Hao Zhang, Junying Wang, Lingxu Li, Nannan Chai, Yuhan Chen, Feixiang Wu, Weihua Zhang, Lina Wang, Sa Shi, Li Zhang, Shuling Bian, Changqing Xu, Ye Tian, Yajun Zhao
Aging is the most important risk factor for cardiovascular disease (CVD). Slowing or reversing the physiological impact of heart aging may reduce morbidity and mortality associated with age-related CVD. The polyamines, spermine (SP) and spermidine (SPD) are essential for cell growth, differentiation and apoptosis, and levels of both decline with age. To explore the effects of these polyamines on heart aging, we administered SP or SPD intraperitoneally to 22- to 24-month-old rats for 6 weeks. Both treatments reversed and inhibited age-related myocardial morphology alterations, myocardial fibrosis, and cell apoptosis...
May 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28610607/resveratrol-distinctively-modulates-the-inflammatory-profiles-of-immune-and-endothelial-cells
#15
Joseph Schwager, Nathalie Richard, Franziska Widmer, Daniel Raederstorff
BACKGROUND: The phenolic substance resveratrol (RES) is a plant metabolite known to modulate numerous physiological functions and to exert beneficial effects as a cancer-chemopreventing agent and on neurological, hepatic, and cardiovascular systems. Since the compound affects the lifespan of yeast and flies it might be an anti-aging substance. Mechanistically, RES is involved in down regulating the inflammatory response. The pleiotropic effects of RES in cells of the immune and endothelial system were examined in this study...
June 13, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28600777/psychoneuroimmunology-developments-in-stress-research
#16
REVIEW
Rainer H Straub, Maurizio Cutolo
Links between the central nervous stress system and peripheral immune cells in lymphoid organs have been detailed through 50 years of intensive research. The brain can interfere with the immune system, where chronic psychological stress inhibits many functions of the immune system. On the other hand, chronic peripheral inflammation-whether mild (during aging and psychological stress) or severe (chronic inflammatory diseases)-clearly interferes with brain function, leading to disease sequelae like fatigue but also to overt psychiatric illness...
June 9, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28597983/celecoxib-for-rheumatoid-arthritis
#17
REVIEW
Mahir Fidahic, Antonia Jelicic Kadic, Mislav Radic, Livia Puljak
BACKGROUND: Rheumatoid arthritis is a systemic auto-immune disorder that causes widespread and persistent inflammation of the synovial lining of joints and tendon sheaths. Presently, there is no cure for rheumatoid arthritis and treatment focuses on managing symptoms such as pain, stiffness and mobility, with the aim of achieving stable remission and improving mobility. Celecoxib is a selective non-steroidal anti-inflammatory drug (NSAID) used for treatment of people with rheumatoid arthritis...
June 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28590332/hiv-positive-youth-who-are-perinatally-infected-have-impaired-endothelial-function
#18
Sahera Dirajlal-Fargo, Abdus Sattar, Manjusha Kulkarni, Emily Bowman, Nicholas Funderburg, Grace A Mccomsey
OBJECTIVE: Evaluating cardiovascular (CVD) risk in children and youth 13-24 years old who are facing a life time exposure to both HIV and antiretroviral therapy (ART) is a research priority. This study compares endothelial function measured by Peripheral Arterial Tonometry in HIV+ youth infected perinatally and behaviorally as well as HIV- controls. METHODS: Three groups of participants aged 8-30 yo were enrolled; HIV+ perinatally-infected, HIV+ behaviorally-infected on ART with HIV-1 RNA <1,000 copies/mL, and HIV- controls...
June 5, 2017: AIDS
https://www.readbyqxmd.com/read/28589505/association-between-supar-and-cardiac-diastolic-dysfunction-among-patients-with-preserved-ejection-fraction
#19
Tomohiro Fujisaka, Shu-Ichi Fujita, Daichi Maeda, Kensaku Shibata, Hideaki Takahashi, Hideaki Morita, Yoshihiro Takeda, Takahide Ito, Koichi Sohmiya, Masaaki Hoshiga, Nobukazu Ishizaka
Serum levels of the soluble urokinase-type plasminogen activator receptor (suPAR) reflect immune and inflammatory activation, and are shown to be associated with cardiovascular outcomes. We herein investigated the potential association between suPAR and left ventricular diastolic dysfunction among patients with preserved left ventricular ejection fraction (LVEF) and sinus rhythm. Among 291 patients who had sinus rhythm and an LVEF of ≥50% enrolled in the study, 26 (8.9%) were considered to have diastolic dysfunction...
June 6, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28579457/metformin-ameliorates-gender-and-age-dependent-hemodynamic-instability-and-myocardial-injury-in-murine-hemorrhagic-shock
#20
Dzmitry Matsiukevich, Giovanna Piraino, Patrick Lahni, Paul W Hake, Vivian Wolfe, Michael O'Connor, Jeanne James, Basilia Zingarelli
Severity of multiple organ failure is significantly impacted by age and gender in patients with hemorrhagic shock. However, the molecular mechanisms underlying the enhanced organ injury are not fully understood. AMP-activated protein kinase (AMPK) is a pivotal orchestrator of metabolic responses during stress. We investigated whether hemorrhage-induced myocardial injury is age and gender dependent and whether treatment with metformin, an AMPK activator, affords cardioprotective effects. C57/BL6 young (3-5months) and mature (9-12months) male and female mice were subjected to hemorrhagic shock by blood withdrawing followed by resuscitation with blood and Lactated Ringer's solution...
June 1, 2017: Biochimica et Biophysica Acta
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