keyword
MENU ▼
Read by QxMD icon Read
search

cardiovascular age immune

keyword
https://www.readbyqxmd.com/read/29136750/-a-perspective-cohort-study-on-influence-factors-of-survival-outcome-among-the-elderly-aged-%C3%A2-80-years-old-from-longevity-areas-in-china
#1
Y B Lyu, J Zhang, J S Luo, W H Shi, Z X Yin, L Q Su, J L Fang, J N Wang, X M Shi
Objective: To investigate the influence factors of survival outcome among elderly aged ≥80 years old. Methods: In baseline survey in 2009, 930 participants aged ≥80 years old were enrolled from 7 longevity areas, to collect the information of socioeconomic factors, life style, cognitive function, activities of daily living and diseases, as well as physical examination to test biomarkers of blood and urine. The survival status was followed up at 2012 and 2014 survey. Stepwise Cox proportional hazards models were used to screen influence factors of 5-year survival...
November 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29130313/the-role-of-biomarkers-in-research-on-caregivers-for-cancer-patients-a-scoping-review
#2
Jumin Park, Alyson Ross, Stephen D Klagholz, Margaret F Bevans
BACKGROUND: Biomarkers can be used as prognostic, predictive, or monitoring indicators of an associated outcome. The purpose of this review was to provide a comprehensive summary of the research examining the use of biomarkers as surrogate end points for clinical outcomes in family caregivers for cancer patients, identify gaps, and make recommendations for future research. METHODS: A scoping review, a process of mapping the existing literature, was conducted. Studies comparing biomarkers across caregivers and controls and/or examining relationships between biomarkers and psychological health were reviewed...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/29114398/multi-system-manifestations-of-mycoplasma-pneumoniae-infection-in-a-young-patient
#3
Ibrahim Al Busaidi, Mohammed Al-Amin, Shadin Ibrahim, Abdullah Balkhair, Zied Gaifer
Introduction.Mycoplasma pneumoniae is a small cell-wall-lacking bacterium that belongs to the mycoplasma (Mollicutes) prokaryote micro-organisms. It is a common cause of both upper and lower respiratory tract infections in all age groups. Respiratory illness is the most common manifestation of M. pneumoniae infection; however, extrapulmonary involvement may be present or predominant. The skin, mucus membranes, central nervous system, cardiovascular system, haematopoietic system, kidneys and musculoskeletal system are the most commonly involved extrapulmonary sites...
September 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29106804/targeting-rage-signaling-in-inflammatory-disease
#4
Barry I Hudson, Marc E Lippman
The receptor for advanced glycation end-products (RAGE) is a multiligand pattern recognition receptor implicated in diverse chronic inflammatory states. RAGE binds and mediates the cellular response to a range of damage-associated molecular pattern molecules (DAMPs) including AGEs, HMGB1, S100s, and DNA. RAGE can also act as an innate immune sensor of microbial pathogen-associated molecular pattern molecules (PAMPs) including bacterial endotoxin, respiratory viruses, and microbial DNA. RAGE is expressed at low levels under normal physiology, but it is highly upregulated under chronic inflammation because of the accumulation of various RAGE ligands...
November 6, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/29101015/dna-damage-metabolism-and-aging-in-pro-inflammatory-t-cells-rheumatoid-arthritis-as-a-model-system
#5
REVIEW
Yinyin Li, Jörg J Goronzy, Cornelia M Weyand
The aging process is the major driver of morbidity and mortality, steeply increasing the risk to succumb to cancer, cardiovascular disease, infection and neurodegeneration. Inflammation is a common denominator in age-related pathologies, identifying the immune system as a gatekeeper in aging overall. Among immune cells, T cells are long-lived and exposed to intense replication pressure, making them sensitive to aging-related abnormalities. In successful T cell aging, numbers of naïve cells, repertoire diversity and activation thresholds are preserved as long as possible; in maladaptive T cell aging, protective T cell functions decline and pro-inflammatory effector cells are enriched...
November 8, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29089944/t-cell-immunosenescence-after-early-life-adversity-association-with-cytomegalovirus-infection
#6
Martha M C Elwenspoek, Krystel Sias, Xenia Hengesch, Violetta K Schaan, Fleur A D Leenen, Philipp Adams, Sophie B Mériaux, Stephanie Schmitz, Fanny Bonnemberger, Anouk Ewen, Hartmut Schächinger, Claus Vögele, Claude P Muller, Jonathan D Turner
Early life adversity (ELA) increases the risk for multiple age-related diseases, such as diabetes type 2 and cardiovascular disease. As prevalence is high, ELA poses a major and global public health problem. Immunosenescence, or aging of the immune system, has been proposed to underlie the association between ELA and long-term health consequences. However, it is unclear what drives ELA-associated immunosenescence and which cells are primarily affected. We investigated different biomarkers of immunosenescence in a healthy subset of the EpiPath cohort...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29084230/effects-of-self-reported-sensitivity-and-road-traffic-noise-levels-on-the-immune-system
#7
Ahra Kim, Joo Hyun Sung, Jin-Hee Bang, Seung Woo Cho, Jiho Lee, Chang Sun Sim
Sensitivity to noise, particularly road traffic noise, can increase cortisol levels and result in changes in immune system biomarkers. Therefore, continuous exposure to noise can have an effect on immune function, hormonal levels, and cardiovascular function, leading to hypertension and stress. The purpose of this study was to investigate the changes in stress-and immune system-related biomarkers according to the self-reported sensitivity to noise and exposure to road traffic noise, to ultimately determine the potential effects of noise on health...
2017: PloS One
https://www.readbyqxmd.com/read/29081381/inflammageing-and-metaflammation-the-yin-and-yang-of-type-2-diabetes
#8
REVIEW
Francesco Prattichizzo, Valeria De Nigris, Rosangela Spiga, Elettra Mancuso, Lucia La Sala, Roberto Antonicelli, Roberto Testa, Antonio Domenico Procopio, Fabiola Olivieri, Antonio Ceriello
Type 2 diabetes mellitus (T2DM) is characterised by chronic low-grade inflammation, recently referred to as 'metaflammation', a relevant factor contributing to the development of both diabetes and its complications. Nonetheless, 'canonical' anti-inflammatory drugs do not yield satisfactory results in terms of prevention of diabetes progression and of cardiovascular events, suggesting that the causal mechanisms fostering metaflammation deserve further research to identify new druggable targets. Metaflammation resembles ageing-induced low-grade inflammation, previously referred to as inflammageing, in terms of clinical presentation and the molecular profile, pointing to a common aetiology for both conditions...
October 31, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/29073286/differential-adipokine-receptor-expression-on-circulating-leukocyte-subsets-in-lean-and-obese-children
#9
Genoveva Keustermans, Laila B van der Heijden, Berlinda Boer, Rianne Scholman, Roos Nuboer, Gerard Pasterkamp, Berent Prakken, Wilco de Jager, Eric Kalkhoven, Arieke J Janse, Henk S Schipper
BACKGROUND: Childhood obesity prevalence has increased worldwide and is an important risk factor for type 2 diabetes (T2D) and cardiovascular disease (CVD). The production of inflammatory adipokines by obese adipose tissue contributes to the development of T2D and CVD. While levels of circulating adipokines such as adiponectin and leptin have been established in obese children and adults, the expression of adiponectin and leptin receptors on circulating immune cells can modulate adipokine signalling, but has not been studied so far...
2017: PloS One
https://www.readbyqxmd.com/read/29051757/role-of-gut-microbiota-on-cardio-metabolic-parameters-and-immunity-in-coronary-artery-disease-patients-with-and-without-type-2-diabetes-mellitus
#10
Lidia Sanchez-Alcoholado, Daniel Castellano-Castillo, Laura Jordán-Martínez, Isabel Moreno-Indias, Pilar Cardila-Cruz, Daniel Elena, Antonio J Muñoz-Garcia, Maria I Queipo-Ortuño, Manuel Jimenez-Navarro
Gut microbiota composition has been reported as a factor linking host metabolism with the development of cardiovascular diseases (CVD) and intestinal immunity. Such gut microbiota has been shown to aggravate CVD by contributing to the production of trimethylamine N-oxide (TMAO), which is a pro-atherogenic compound. Treg cells expressing the transcription factor Forkhead box protein P3 (FoxP3) play an essential role in the regulation of immune responses to commensal microbiota and have an atheroprotective role...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29046030/-immunopathology-of-chronic-obstructive-pulmonary-disease
#11
Nora Ernestina Martínez-Aguilar, María Eugenia Vargas-Camaño, Rogelio Ramsés Hernández-Pliego, Genny Margarita Chaia-Semerena, María Rosario Pérez-Chavira
Chronic obstructive pulmonary disease (COPD) is a common, preventable and treatable condition that has a complex pathophysiology and an even more complex immunopathological process. The purpose of this review was to analyze COPD immunopathological aspects, which was addressed by undertaking a literature search for the most relevant documents indexed in the PubMed database over the last 10 years. Different conclusions could be drawn: in COPD immunopathology there are immune and non-immune inflammatory changes with oxidative stress imbalance, there are alterations in the protease/anti-protease ratio caused by direct and indirect genetic and epigenetic-environmental defects; COPD produces irreversible tissue damage and chronic inflammation with tissue repair alteration, which induces chronic obstruction of the airway, bronchitis and systemic damage...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29045253/gut-microbial-diversity-in-hiv-infection-post-combined-antiretroviral-therapy-a-key-target-for-prevention-of-cardiovascular-disease
#12
Mohamed El-Far, Cécile L Tremblay
PURPOSE OF REVIEW: Although the HIV-infected population is living longer and getting older under current treatment regimens, significant challenges arise for health management as the infection is associated with various premature aging phenotypes, particularly increased incidence of cardiovascular diseases (CVDs). Here we review the current understanding of HIV-related gut dysbiosis in association with CVD and advances in clinical trials aiming to restore gut microbial diversity. RECENT FINDING: Identification of a unique signature for gut dysbiosis in HIV infection between different cohorts remains challenging...
October 25, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29029392/spermine-and-spermidine-reversed-age-related-cardiac-deterioration-in-rats
#13
Hao Zhang, Junying Wang, Lingxu Li, Nannan Chai, Yuhan Chen, Feixiang Wu, Weihua Zhang, Lina Wang, Sa Shi, Li Zhang, Shuling Bian, Changqing Xu, Ye Tian, Yajun Zhao
Aging is the most important risk factor for cardiovascular disease (CVD). Slowing or reversing the physiological impact of heart aging may reduce morbidity and mortality associated with age-related CVD. The polyamines, spermine (SP) and spermidine (SPD) are essential for cell growth, differentiation and apoptosis, and levels of both decline with age. To explore the effects of these polyamines on heart aging, we administered SP or SPD intraperitoneally to 22- to 24-month-old rats for 6 weeks. Both treatments reversed and inhibited age-related myocardial morphology alterations, myocardial fibrosis, and cell apoptosis...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29022261/the-non-cardiomyocyte-cells-of-the-heart-their-possible-roles-in-exercise-induced-cardiac-regeneration-and-remodeling
#14
Ivan Varga, Jan Kyselovič, Paulina Galfiova, Lubos Danisovic
The non-cardiomyocyte cellular microenvironment of the heart includes diverse types of cells of mesenchymal origin. During development, the majority of these cells derive from the epicardium, while a subset derives from the endothelium/endocardium and neural crest derived mesenchyme. This subset includes cardiac fibroblasts and telocytes, the latter of which are a controversial type of "connecting cell" that support resident cardiac progenitors in the postnatal heart. Smooth muscle cells, pericytes, and endothelial cells are also present, in addition to adipocytes, which accumulate as epicardial adipose connective tissue...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29021852/association-between-serum-soluble-urokinase-type-plasminogen-activator-receptor-and-atrial-fibrillation
#15
Noboru Ichihara, Masatoshi Miyamura, Daichi Maeda, Tomohiro Fujisaka, Shu-Ichi Fujita, Hideaki Morita, Yoshihiro Takeda, Takahide Ito, Koichi Sohmiya, Masaaki Hoshiga, Nobukazu Ishizaka
BACKGROUND: Circulating soluble urokinase-type plasminogen activator receptor (suPAR), which can reflect immune activation and low-grade inflammation, may be a novel biomarker of cardiovascular disease. METHODS: We investigated the potential association between suPAR and the prevalence of atrial fibrillation (AF) by analyzing patients with either sinus rhythm, paroxysmal atrial fibrillation (PAF), or non-paroxysmal atrial fibrillation (NPAF), which indicates either permanent or persistent AF...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29017617/birth-weight-and-postnatal-microbial-exposures-predict-the-distribution-of-peripheral-blood-leukocyte-subsets-in-young-adults-in-the-philippines
#16
T W McDade, M J Jones, G Miller, J Borja, M S Kobor, C W Kuzawa
The immune system not only provides protection against infectious disease but also contributes to the etiology of neoplastic, atopic, and cardiovascular and metabolic diseases. Prenatal and postnatal nutritional and microbial environments have lasting effects on multiple aspects of immunity, indicating that immune processes may play important roles in the developmental origins of disease. The objective of this study is to evaluate the association between birth weight and the distribution of leukocyte (white blood cell) subsets in peripheral blood in young adulthood...
October 11, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28984702/current-assessment-of-heart-rate-variability-and-qtc-interval-length-in-hiv-aids
#17
Roger C McIntosh, Judith D Lobo, Barry E Hurwitz
PURPOSE OF REVIEW: The increasing prevalence of cardiovascular disease comorbidity in persons infected with the HIV has become a global concern. The electrocardiogram (ECG) is increasingly being utilized to provide clinically relevant information regarding cardiac arrhythmias and cardio-autonomic dysfunction. The purpose of this review is to summarize the latest research comparing QT and R-to-R interval length as a function of HIV+ status or antiretroviral therapy (ART) regimen. RECENT FINDINGS: Prolongation of the corrected QTc interval may be acquired in HIV+ ART-naive individuals, exacerbated by various classes of ART drugs, and is generally predictive of lethal cardiac arrhythmias, with effects observed from childhood to adulthood...
November 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28978180/immunological-consequences-of-ageing-microvascular-hemodynamic-changes-in-view-of-cancer-development-and-treatment
#18
REVIEW
Jinhyuk Fred Chung, Sang Joon Lee, Anil K Sood
Risk factors of cardiovascular diseases have long been implicated as risk factors for carcinogenesis, but clear explanations for their association have not been presented. In this article, fundamental concepts from carcinogenesis, microvascular hemodynamics, and immunity are collectively reviewed and analyzed in context of the known features of vascular ageing effects, in formulating a theory that suggests reduced microvascular immunity as an important driving factor for carcinogenesis. Furthermore, scientific, preclinical, and clinical evidence that support this new theory are presented in an interdisciplinary manner, offering new explanations to previously unanswered factors that impact cancer risks and its treatment outcome such as chronic drug use, temperature, stress and exercise effects among others...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28974102/the-effect-of-rosuvastatin-on-vascular-disease-differs-by-smoking-status-in-treated-hiv-infection
#19
Corrilynn Olesky Hileman, Grace A McComsey
BACKGROUND: Smoking is an important contributor to cardiovascular disease (CVD) risk and is highly prevalent in the HIV population. In SATURN-HIV, a 96-week, randomized placebo-controlled trial testing the effect of rosuvastatin on subclinical vascular disease and immune activation in HIV-infected adults, rosuvastatin improved immune activation and arrested common carotid artery intima media thickness (CCA IMT) progression. METHODS: In this exploratory analysis, ANOVA was used to test for effect modification by smoking...
October 3, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28945911/hdl-cholesterol-efflux-capacity-in-newly-diagnosed-hiv-and-effects-of-antiretroviral-therapy
#20
Mabel Toribio, Min Hi Park, Markella V Zanni, Gregory K Robbins, Tricia H Burdo, Kenneth C Williams, Meghan N Feldpausch, Lauren Stone, Kathleen Melbourne, Steven K Grinspoon, Michael L Fitzgerald
Context: In the general population, high-density lipoprotein (HDL) cholesterol efflux capacity (HCEC) relates inversely to incident cardiovascular events. Previous studies have suggested that HCEC is decreased in HIV and that antiretroviral therapy (ART) initiation might improve HCEC. Objective: To evaluate HCEC in the context of ART initiation and immune activation in HIV. Design and Outcome Measures: Baseline HCEC from 10 ART-naive HIV-infected males and 12 prospectively matched non-HIV-infected males were analyzed...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
keyword
keyword
80379
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"