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https://www.readbyqxmd.com/read/27926762/association-of-arterial-and-lymph-node-inflammation-with-distinct-inflammatory-pathways-in-human-immunodeficiency-virus-infection
#1
Ahmed Tawakol, Amorina Ishai, Danny Li, Richard A P Takx, Sophia Hur, Yannick Kaiser, Miguel Pampaloni, Adam Rupert, Denise Hsu, Irini Sereti, Rémi Fromentin, Nicolas Chomont, Peter Ganz, Steven G Deeks, Priscilla Y Hsue
Importance: Human immunodeficiency virus (HIV) infection is associated with a high risk of cardiovascular disease and increased arterial inflammation. In HIV, inflammation is also increased within lymph nodes (LNs), tissues known to harbor the virus even among treated and suppressed individuals. Objective: To test the hypothesis that arterial inflammation is linked to HIV disease activity and to inflammation within HIV-infected tissues (LNs). Design, Setting, and Participants: For this case-control study, participants were recruited from the SCOPE (Observational Study of the Consequences of the Protease Inhibitor Era) cohort, a clinic-based cohort of individuals receiving care at San Francisco General Hospital and the San Francisco Veteran's Affairs Medical Center...
December 7, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27925863/susceptibility-of-rubella-among-pregnant-women-attending-the-antenatal-clinic-in-a-tertiary-care-hospital-jabalpur-central-india
#2
Bhupesh K Kori, Kavita N Singh, Ravendra K Sharma, Bhagwati S Sharma, Poorva Badkur, Pradip V Barde
The purpose of this study was to evaluate rubella susceptibility of pregnant women from central India as rubella infection can be devastating for the newborn if it occurs in the mother in the first trimester of pregnancy, which may lead to congenital rubella syndrome (CRS). There are very few studies about seroprevalence of rubella from India and none from central India. The study was conducted among women attending the obstetric department of a tertiary care hospital, in which 369 antenatal cases were tested for the presence of immunoglobulin G antibody for rubella and its titer...
December 7, 2016: Viral Immunology
https://www.readbyqxmd.com/read/27925856/clinical-and-economic-impact-of-herpes-zoster-vaccination-in-elderly-in-italy
#3
Sara Boccalini, Cristiano Alicino, Domenico Martinelli, Angela Bechini, Emilia Tiscione, Barbara Pellizzari, Rosa Prato, Giancarlo Icardi, Stefania Iannazzo, Paolo Bonanni
Herpes zoster (HZ) is a very relevant pathology among elderly people (≥ 60 years of age), with a considerable disease burden and loss of quality of life. In the last years a new vaccine against HZ became available in Italy. Therefore, the Italian decision makers are now confronted with the decision whether that vaccination should be implemented. Pharmaco-economic analyses represent useful tools to value the feasibility of new immunization programs and their sustainability. To this aim, an ad hoc population model was developed in order to value the clinical and economic impact of HZ vaccination program for the elderly in Italy...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27925503/persistence-of-protective-anti-hbs-antibody-levels-and-anamnestic-response-to-hbv-booster-vaccination-a-cross-sectional-study-among-healthcare-students-20%C3%A2-years-following-the-universal-immunization-campaign-in-italy
#4
Guglielmo Dini, Alessandra Toletone, Ilaria Barberis, Nicoletta Debarbieri, Emanuela Massa, Chiara Paganino, Francesca Bersi, Alfredo Montecucco, Cristiano Alicino, Paolo Durando
Vaccination against Hepatitis B Virus (HBV) became mandatory in Italy for all newborns and twelve years-old individuals in the 1991. The immunogenicity of HBV vaccine and the effectiveness of the universal immunization strategy have been widely demonstrated. However the need to assess the antibody concentrations above the well known serological correlate of protection for HBV infection (≥ 10 mIU/mL), established in individuals immunized with a three doses vaccination course, is still recommended in subjects exposed to occupational risks in different settings, particularly the healthcare services...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27925154/prenatal-exposure-to-maternal-bereavement-and-offspring-psoriasis-a-danish-nationwide-cohort-study
#5
X Liu, J Chen, J Olsen, V Schlünssen, N Momen, J Li
BACKGROUND: Prenatal stress may alter immune competence of the foetus. Limited data exist on the role of antenatal stress in psoriasis development. We aimed to investigate whether prenatal exposure to maternal bereavement increased the risk of offspring psoriasis. METHODS: This register-based cohort study included 1,811,917 live singletons born 1978-2008 in Denmark. The children were assigned to the bereaved group if their mothers lost a child, partner/spouse, a parent or a sibling during pregnancy or up to 12 months before pregnancy...
December 7, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27924726/neurodegenerative-disease-a-perspective-on-cell-based-therapy-in-the-new-era-of-cell-free-nano-therapy
#6
Su M Metcalfe, Sean Bickerton, Tarek Fahmy
Neurodegenerative diseases (NDD) result in irreversible loss of neurons. Dementia develops when disease-induced neuronal loss becomes sufficient to impair both memory and cognitive functioning and, globally, dementia is increasing to epidemic proportions as populations age. In the current era of regenerative medicine intense activity is asking, can loss of endogenous neurons be compensated by replacement with exogenously derived cells that have either direct, or indirect, neurogenic capacity? But, more recently, excitement is growing around an emerging alternative to the cell-based approach - here nanotechnology for targeted delivery of growth factor aims to support and expand resident central nervous system (CNS) stem cells for endogenous repair...
December 6, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27924246/adenovirus-and-culture-negative-sepsis-in-a-preterm-neonate
#7
Mohannad Moallem, Eunkyung Song, Preeti Jaggi, Miriam R Conces, Adriana E Kajon, Pablo J Sánchez
Background Respiratory viral infections remain an underrecognized cause of morbidity and mortality among preterm infants in the neonatal intensive care unit (NICU). Case Report An eight day old, 650 gram birth weight, 23 weeks' gestational age female developed "culture-negative" sepsis manifested by respiratory deterioration, hypoxia, leukocytosis, and thrombocytopenia. She was diagnosed with pneumonia and hepatitis due to adenovirus HAdV-D (H29F9) by polymerase chain reaction (PCR) testing, but died at the age of 18 days despite treatment with cidofovir and immune globulin intravenous...
October 2016: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/27923248/timing-of-multiorgan-dysfunction-among-hospitalized-infants-with-fatal-fulminant-sepsis
#8
James L Wynn, Matthew S Kelly, Daniel K Benjamin, Reese H Clark, Rachel Greenberg, Daniel K Benjamin, P Brian Smith
Objective Identify the progression of specific signs of multiorgan dysfunction among infants with fatal sepsis. Study Design Cohort study of 679 infants who died within 3 days of the start of a late-onset sepsis (LOS) episode in neonatal intensive care units from 1997 to 2012. We extracted clinical and laboratory data on the day of death (day 0) and the preceding 5 days (days -5 to -1). Results Median (25th percentile-75th percentile) gestational age was 25 (24-28) weeks. Compared with day -1, day 0 was characterized by an increased requirement for mechanical ventilation and higher mean fraction of inspired oxygen...
December 6, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27921083/integrated-role-of-bifidobacterium-animalis-subsp-lactis-supplementation-in-gut-microbiota-immunity-and-metabolism-of-infant-rhesus-monkeys
#9
Xuan He, Carolyn M Slupsky, James W Dekker, Neill W Haggarty, Bo Lönnerdal
To investigate the impact of probiotic supplementation of infant formula on immune parameters, intestinal microbiota, and metabolism, five individually housed infant rhesus monkeys exclusively fed standard infant formula supplemented with probiotics (Bifidobacterium animalis subsp. lactis HN019) from birth until 3 months of age were compared with five standard formula-fed and five breast-fed monkeys. Anthropometric measurements, serum insulin, immune parameters, fecal microbiota, and metabolic profiles of serum, urine, and feces were evaluated...
November 2016: MSystems
https://www.readbyqxmd.com/read/27920759/immune-responses-to-influenza-virus-and-its-correlation-to-age-and-inherited-factors
#10
REVIEW
Azadeh Bahadoran, Sau H Lee, Seok M Wang, Rishya Manikam, Jayakumar Rajarajeswaran, Chandramathi S Raju, Shamala D Sekaran
Influenza viruses belong to the family Orthomyxoviridae of enveloped viruses and are an important cause of respiratory infections worldwide. The influenza virus is able to infect a wide variety species as diverse as poultry, marine, pigs, horses, and humans. Upon infection with influenza virus the innate immunity plays a critical role in efficient and rapid control of viral infections as well as in adaptive immunity initiation. The humoral immune system produces antibodies against different influenza antigens, of which the HA-specific antibody is the most important for neutralization of the virus and thus prevention of illness...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27920756/salmonella-typhimurium-and-multidirectional-communication-in-the-gut
#11
REVIEW
Elena V Gart, Jan S Suchodolski, Thomas H Welsh, Robert C Alaniz, Ronald D Randel, Sara D Lawhon
The mammalian digestive tract is home to trillions of microbes, including bacteria, archaea, protozoa, fungi, and viruses. In monogastric mammals the stomach and small intestine harbor diverse bacterial populations but are typically less populated than the colon. The gut bacterial community (microbiota hereafter) varies widely among different host species and individuals within a species. It is influenced by season of the year, age of the host, stress and disease. Ideally, the host and microbiota benefit each other...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27920395/tetanus-immunity-gaps-in-children-5-14-years-and-men-%C3%A2-15-years-of-age-revealed-by-integrated-disease-serosurveillance-in-kenya-tanzania-and-mozambique
#12
Heather M Scobie, Minal Patel, Diana Martin, Harran Mkocha, Sammy M Njenga, Maurice R Odiere, Sonia Pelletreau, Jeffrey W Priest, Ricardo Thompson, Kimberly Y Won, Patrick J Lammie
Recent tetanus cases associated with male circumcision in Eastern and Southern Africa (ESA) prompted an examination of tetanus immunity by age and sex using multiplex serologic data from community surveys in three ESA countries during 2012-2013. Tetanus seroprotection was lower among children 5-14 years versus 1-4 years of age in Kenya (66% versus 90%) and Tanzania (66% versus 89%), but not in Mozambique (91% versus 88%), where children receive two booster doses in school. Among males ≥ 15 years of age, tetanus seroprotection was lower than females in Kenya (45% versus 96%), Tanzania (28% versus 94%), and Mozambique (64% versus 90%)...
December 5, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27919841/prevalence-of-non-adherence-to-highly-active-antiretroviral-therapy-and-its-related-clinical-and-therapeutic-factors-in-ouagadougou-burkina-faso
#13
O Guira, D S R Kaboré, G Dao, N Zagré, T M Zohoncon, V Pietra, J Simporé
: Introduction : Non-adherence to highly active antiretroviral therapy is deleterious in HIV/AIDS programs. This study contributes to the identification of its frequency and of the clinical and therapeutic factors that determine it. Material and methods : This cross-sectional study took place from December 15, 2013, to February 18, 2014, at the Saint Camille health care center and the Pietro Annigoni biomolecular research center in Ouagadougou. It includes adults who had been receiving antiretroviral therapy for at least three months and agreed to participate...
December 5, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/27919632/immunogenicity-and-safety-of-a-13-valent-pneumococcal-conjugate-vaccine-and-an-mf59-adjuvanted-influenza-vaccine-after-concomitant-vaccination-in-%C3%A2-60-year-old-adults
#14
Joon Young Song, Hee Jin Cheong, Hak Jun Hyun, Yu Bin Seo, Jacob Lee, Seong-Heon Wie, Min Joo Choi, Won Suk Choi, Ji Yun Noh, Jae Won Yun, Jin Gu Yun, Woo Joo Kim
BACKGROUND: Concomitant administration of influenza and pneumococcal vaccines could be an efficient strategy to increase vaccine uptake among older adults. Nevertheless, immune interference and safety issues have been a concern when more than one vaccines are administered at the same time. METHODS: Subjects aged ⩾60years were randomized in a 1:1:1 ratio to receive MF59-adjuvanted trivalent inactivated influenza vaccine (MF59-aTIV)+13-valent pneumococcal conjugate vaccine (PCV13) (Group 1), PCV13 alone (Group 2), or MF59-aTIV alone (Group 3)...
December 2, 2016: Vaccine
https://www.readbyqxmd.com/read/27919289/correlates-of-sex-trading-among-male-non-injecting-drug-users-in-myanmar-a-cross-sectional-study
#15
Yu Mon Saw, Thu Nandar Saw, Kyi Mar Wai, Krishna C Poudel, Hla Hla Win
BACKGROUND: Sex trading is a recognized risk factor for human immune deficiency virus infection and other sexually transmitted infections among non-injecting drug users (NIDUs). However, very little research has addressed the factors associated with sex trading among male NIDUs in Myanmar. METHODS: A cross-sectional study was conducted from January to February 2010 using the respondent-driven sampling method. In total, 210 NIDUs aged between 18 and 49 years, with no history of injecting drug use, and who used non-injected illicit drugs in the last 6 months were recruited...
December 5, 2016: Harm Reduction Journal
https://www.readbyqxmd.com/read/27918760/risk-factors-protective-factors-and-current-recommendations-to-reduce-sudden-infant-death-syndrome-a-review
#16
Rebecca F Carlin, Rachel Y Moon
Importance: Sudden infant death syndrome remains the leading cause of death in infants aged 1 month to 1 year in the United States. Observations: While its exact cause is unknown, sudden infant death syndrome is believed to be multifactorial, ie, occurs in infants with underlying biological vulnerability who experience an exogenous stressor, such as prone/side sleeping or soft bedding, during a critical developmental period. Much genetic and physiologic evidence points to impaired arousal responses to hypercarbia and hypoxia, which ultimately leads to asphyxia...
December 5, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27918167/-coeliac-disease-as-a-possible-cause-of-some-gynecological-and-obstetric-abnormalities
#17
K Fiolková, K Biringer, M Hrtánková, R Fiolka, J Danko
OBJECTIVE: To bring a review of available literature sources on the prevalence of coeliac disease and its possible impact on gynecological and obstetric disorders. DESIGN: Review article. SETTING: Gynecology and Obstetrics Clinic, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia. METHODS: Analysis of literary sources. CONCLUSION: Coeliac disease is an autoimmune enteropathy caused by abnormal immune system response to gluten...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27917918/distinct-epigenomes-in-cd4-t-cells-of-newborns-middle-ages-and-centenarians
#18
Ming Zhao, Jian Qin, Hanqi Yin, Yixin Tan, Wei Liao, Qian Liu, Shuangyan Luo, Min He, Gongping Liang, Yajing Shi, Qing Zhang, Wenjun Cai, Guangliang Yin, Yin Zhou, Jing Wang, Mengying Li, Yi Huang, Aiyun Liu, Haijing Wu, Zhiyong Zhang, Qianjin Lu
Age-related variations in genes and microRNAs expression and DNA methylation have been reported respectively; however, their interactions during aging are unclear. We therefore investigated alterations in the transcriptomes, miRNAomes and DNA methylomes in the same CD4(+)T cells from newborn (NB), middle-aged (MA) and long-lived (LL) individuals to elucidate the molecular changes and their interactions. A total 659 genes showed significantly expression changes across NB, MA and LL individuals, in which we identified four age-related co-expression modules with three hub networks of co-expressed genes and non-coding RNAs...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917879/colonic-luminal-microbiota-and-bacterial-metabolite-composition-in-pregnant-huanjiang-mini-pigs-effects-of-food-composition-at-different-times-of-pregnancy
#19
Xiang-Feng Kong, Yu-Jiao Ji, Hua-Wei Li, Qian Zhu, F Blachier, Mei-Mei Geng, Wen Chen, Yu-Long Yin
The gut harbours diverse and complex microbiota, which influence body health including nutrient metabolism, immune development, and protection from pathogens. Pregnancy is associated with immune and metabolic changes that might be related to microbiota compositional dynamics. We therefore investigated the colonic luminal bacteria community in Huanjiang mini-pigs fed diets with different nutrient levels from the first to third trimester of pregnancy. The concentrations of intestinal metabolites including short-chain fat acids, NH3-N, indole, skatole, and bioamines were also determined...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917805/right-sided-lateralization-of-skin-temperature-in-healthy-young-persons
#20
Havva Demirel, Arzu Bahar, Nurcan Gokgoz, Muzeyyen Arslan, Senol Dane
PURPOSE: Previous studies reported a peripheral immune asymmetry and lateralization of different paired organ cancers. Because of the close relationship of immune system with body temperature, the aim of the study was to test the possible lateralization of skin temperature. MATERIALS AND METHODS: Four hundred sixty three healthy subjects (325 women, 138 men) with an average age of 23.62 years (SD = 8.65) participated in this study. All skin temperature measurements were done 8:00-9:00 a...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
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