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Wen Liu, Yalun Wang, Xiao Han, Ping Lu, Liang Zhu, Chaowei Sun, Jun Qian, Sailing He
Near-infrared (NIR) fluorescence is very important for high-contrast biological imaging of high-scattering tissues such as brain tissue. Unfortunately, commercial NIR dyes are excited usually by visible light, and their multi-photon absorption (MPA) cross-sections are small. Here, we design new co-encapsulated NIR nanoparticles (NPs) with a large three-photon (3PA) absorption cross-section. A form of aggregation-induced emission (AIE) luminogen (AIEgen), 2,3-bis(4'-(diphenylamino)-[1,1'-biphenyl]-4-yl) fumaronitrile (TPATCN), is introduced as the donor, and a form of NIR dye, silicon 2,3-naphthalocyanine bis-(trihexylsilyloxide) (NIR775), is adopted as the acceptor...
May 18, 2018: Nanoscale
Linda Ross, Wilfred McSherry, Tove Giske, René van Leeuwen, Annemiek Schep-Akkerman, Tiburtius Koslander, Jenny Hall, Vibeke Østergaard Steenfeldt, Paul Jarvis
BACKGROUND: Nurses and midwives care for people at some of the most vulnerable moments of their lives, so it is essential that they have the skills to give care which is compassionate, dignified, holistic and person-centred. Holistic care includes spiritual care which is concerned with helping people whose beliefs, values and sense of meaning, purpose and connection is challenged by birth, illness or death. Spiritual care is expected of nurses/midwives but they feel least prepared for this part of their role...
May 9, 2018: Nurse Education Today
Nefyn H Williams, Kevin Mawdesley, Jessica L Roberts, Nafees Ud Din, Nicola Totton, Joanna M Charles, Zoe Hoare, Rhiannon T Edwards
Background: Health economic evaluations rely on the accurate measurement of health service resource use in order to calculate costs. These are usually measured with patient completed questionnaires using instruments such as the Client Service Receipt Inventory (CSRI). These rely on participants' recall and can be burdensome to complete. Health service activity data are routinely captured by electronic databases.The aim was to test methods for obtaining these data and compare with those data collected using the CSRI, within a feasibility study of an enhanced rehabilitation intervention following hip fracture (Fracture in the Elderly Multidisciplinary Rehabilitation: FEMuR)...
2018: Pilot and Feasibility Studies
Christopher Francklyn, Herve Roy, Rebecca Alexander
The 11th IUBMB Focused Meeting on Aminoacyl-tRNA Synthetases was held in Clearwater Beach, Florida from 29 October⁻2 November 2017, with the aim of presenting the latest research on these enzymes and promoting interchange among aminoacyl-tRNA synthetase (ARS) researchers. Topics covered in the meeting included many areas of investigation, including ARS evolution, mechanism, editing functions, biology in prokaryotic and eukaryotic cells and their organelles, their roles in human diseases, and their application to problems in emerging areas of synthetic biology...
May 1, 2018: Biomolecules
Te An Kung, Shu Hui Lee, Ting Chi Yang, Wei Hsien Wang
Kenting National Park (KNP) located in the Hengchun Peninsula in southern Taiwan is a popular tourist spot, annually attracting millions of visitors, who engage in water sport and amusement activities. In this region, sewage is directly discharged into the marine environment. In this study, the concentrations of five organic UV filters [benzophenone (BP), 2,4-dihydroxy benzophenone (BP-1), 2-hydroxy-4-methoxy benzophenone (BP-3), 2,2'-dihydroxy-4-methoxy benzophenone (BP-8), and 4-methylbenzylidene camphor], five preservatives [methylparaben (MeP), ethylparaben, propylparaben (PrP), butylparaben, and benzylparaben], one disinfectant [triclosan (TCS)], and twenty-four detergent derivatives [nonylphenol (NP), nonylphenol ethoxylates (NP2EO-NP12EO), octylphenol (OP) and octylphenol ethoxylates OP2EO-OP12EO] were detected in seawater and river water samples collected from eight beaches in KNP and two major river estuaries in the Hengchun Peninsula...
April 23, 2018: Science of the Total Environment
Weina Zhang, Bing Zheng, Wenxiong Shi, Xinyi Chen, Zhiling Xu, Shuzhou Li, Yonggui Robin Chi, Yanhui Yang, Jun Lu, Wei Huang, Fengwei Huo
The site-selective reaction of a multifunctional linear molecule requires a suitable catalyst possessing both uniform narrow channel to limit the molecule rotation and a designed active site in the channel. Recently, nanoparticles (NPs) were incorporated in metal-organic frameworks (MOFs) with the tailorable porosity and ordered nanochannel, which makes these materials (NPs/MOFs) highly promising candidates as catalytic nanoreactors in the field of heterogeneous catalysis. Inspired by a "Gondola" sailing in narrow "Venetian Canal" without sufficient space for a U-turn, a simple heterogeneous catalyst based on NPs/MOFs is developed that exhibits site-selectivity for the oxidation of diols by restricting the random rotation of the molecule (the "Gondola") in the limited space of the MOF channel (the narrow "Venetian Canal"), thereby protecting the middle functional group via steric hindrance...
April 30, 2018: Advanced Materials
Jianwei Tang, Juan Xia, Maodong Fang, Fanglin Bao, Guanjun Cao, Jianqi Shen, Julian Evans, Sailing He
Plasmon-emitter hybrid nanocavity systems exhibit strong plasmon-exciton interactions at the single-emitter level, showing great potential as testbeds and building blocks for quantum optics and informatics. However, reported experiments involve only one addressable emitting site, which limits their relevance for many fundamental questions and devices involving interactions among emitters. Here we open up this critical degree of freedom by demonstrating selective far-field excitation and detection of two coupled quantum dot emitters in a U-shaped gold nanostructure...
April 27, 2018: Nature Communications
Natalia Nikonorova, Kun Yue, Tom Beeckman, Ive De Smet
More and more reports question conclusions based on loss-of-function lines that have unexpected genetic backgrounds. In this Opinion, we urge researchers to meticulously (re)investigate phenotypes retrieved from various genetic backgrounds and be critical regarding some previously drawn conclusions. As an example, we provide new evidence that acr4-2 mutant phenotypes with respect to columella stem cells are due to the lack of ACR4 and not - at least not as a major contributor - to a mutation in QRT1. In addition, we take the opportunity to alert the scientific community about the qrt1-2 background of a large number of Syngenta Arabidopsis Insertion Library (SAIL) T-DNA lines, a feature that is not commonly recognized by Arabidopsis researchers...
April 26, 2018: Journal of Experimental Botany
Eun-Jung Cho, Dae-Hyun Ko, Woochang Lee, Sail Chun, Hae Kyung Lee, Won-Ki Min
BACKGROUND: The manual microscopic examination (MME) of urine sediment is labor-intensive, time-consuming, and imprecise. Therefore, automated urinalysis systems based on flow cytometry or digital imaging techniques could replace MME. The purpose of this study was to evaluate the rate of MME using two automated urine sediment analyzers, alone and in combination. METHODS: This study was conducted using the freshly collected urine specimens of 1055 in-patients and 1119 out-patients...
April 12, 2018: Clinical Biochemistry
David J Clark, John Tyson, Andrew D Sails, Sanjeev Krishna, Henry M Staines
Nucleic acid testing (NAT) for pathogenic filoviruses plays a key role in surveillance and to control the spread of infection. As they share clinical features with other pathogens, the initial spread of these viruses can be misdiagnosed. Tests that can identify a pathogen in the initial stages of infection are essential to control outbreaks. Since the Ebola virus disease (EVD) outbreak in 2014-2016 several tests have been developed that are faster than previous tests and more suited for field use. Furthermore, the ability to test for a range of pathogens simultaneously has been expanded to improve clinical pathway management of febrile syndromes...
March 22, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Cristiane Sá Roriz Fonteles, Erlane Marques Ribeiro, Marinisi Sales Aragão Santos, Rebeka Ferreira Pequeno Leite, Gabryela Sales Assunção, André Jalles Monteiro, André Luiz Santos Pessoa, Célia Maria Giacheti, Sáile Cavalcante Kerbage, Thyciana Rodrigues Ribeiro, Luciano Pamplona de Góes Cavalcanti
OBJECTIVE: The present study aimed to evaluate lingual frenulum in children affected by congenital Zika syndrome (CZS) and to analyze the association of lingual frenulum phenotypes with other variables. DESIGN: This present work had a cross-sectional, descriptive study design. SETTING: This study was carried out in Fortaleza (Brazil). The health professionals provided tertiary level of care. Data collection occurred during a multidisciplinary task force for evaluating infants affected by CZS in December 2 to 3, 2016...
January 1, 2018: Cleft Palate-craniofacial Journal
Giulio Nittari, Graziano Pallotta, Marzio Di Canio, Enea Traini, Francesco Amenta
BACKGROUND: Benzodiazepines are drugs widely used for the treatment of anxiety and insomnia. The present study has analysed the prescriptions of this class of drugs among sailing seafarers, to evaluate the appropriateness of prescribed therapies. MATERIALS AND METHODS: This study assessed the benzodiazepine prescriptions made by Centro Internazionale Radio Medico (CIRM) doctors from 2011 to 2015. A total of 17,844 medical records were examined. Analysis considered the prescriptions of benzodiazepines in monotherapy, or in association with other drugs...
2018: International Maritime Health
Nadja Saile, Lisa Schwarz, Kristina Eißenberger, Jochen Klumpp, Florian W Fricke, Herbert Schmidt
Enterohemorrhagic E. coli (EHEC) are serious bacterial pathogens which are able to cause a hemorrhagic colitis or the life-threatening hemolytic-uremic syndrome (HUS) in humans. EHEC strains can carry different numbers of phage-borne nanS-p alleles that are responsible for acetic acid release from mucin from bovine submaxillary gland and 5-N-acetyl-9-O-acetyl neuraminic acid (Neu5,9Ac2 ), a carbohydrate present in mucin. Thus, Neu5,9Ac2 can be transformed to 5-N-acetyl neuraminic acid, an energy source used by E...
March 26, 2018: International Journal of Medical Microbiology: IJMM
Zheping Yan, Lu Wang, Tongda Wang, Zewen Yang, Tao Chen, Jian Xu
To solve the navigation accuracy problems of multi-Unmanned Underwater Vehicles (multi-UUVs) in the polar region, a polar cooperative navigation algorithm for multi-UUVs considering communication delays is proposed in this paper. UUVs are important pieces of equipment in ocean engineering for marine development. For UUVs to complete missions, precise navigation is necessary. It is difficult for UUVs to establish true headings because of the rapid convergence of Earth meridians and the severe polar environment...
March 30, 2018: Sensors
J E Bos, R B van Leeuwen, T D Bruintjes
- Motion sickness is not a disorder, but a normal response to a non-normal situation in which movement plays a central role, such as car travel, sailing, flying, or virtual reality.- Almost anyone can suffer from motion sickness, as long as at least one of the organs of balance functions. If neither of the organs of balance functions the individual will not suffer from carsickness, seasickness, airsickness, nor from cybersickness. - 'Cybersickness' is a form of motion sickness that is stimulated by artificial moving images such as in videogames...
2018: Nederlands Tijdschrift Voor Geneeskunde
Fang Li, Huilin Zhu, Jie Xu, Qianqian Gao, Huan Guo, Shijing Wu, Xinge Li, Sailing He
Functional near-infrared spectroscopy (fNIRS) was used to test whether monitoring inhibition-related brain regions is a feasible method for detecting both infrequent liars and frequent liars. Thirty-two participants were divided into two groups: the deceptive group (liars) and the non-deceptive group (ND group, innocents). All the participants were required to undergo a simulated interrogation by a computer. The participants from the deceptive group were instructed to tell a mix of lies and truths and those of the ND group were instructed always to tell the truth...
2018: Frontiers in Human Neuroscience
Jeremy Hsu
No abstract text is available yet for this article.
September 19, 2017: Scientific American
Kendall Powell
No abstract text is available yet for this article.
March 22, 2018: Nature
Ying Huang, Keke Han, Qian Ren
Toll receptors are involved in innate immunity of invertebrates. In this study, we identify and characterize two Toll genes (named HcToll4 and HcToll5 ) from triangle sail mussel Hyriopsis cumingii. HcToll4 has complete cDNA sequence of 3,162 bp and encodes a protein of 909 amino acids. HcToll5 cDNA is 4,501 bp in length and encodes a protein of 924 amino acids. Both deduced HcToll4 and HcToll5 protein contain signal peptide, extracellular leucine rich repeats (LRRs), and intracellular Toll/interleukin-1 (IL-1) receptor domains...
2018: Frontiers in Physiology
Shijing Wu, Jun Li, Lantian Gao, Changshui Chen, Sailing He
Hemodynamic response to motor execution (ME) and motor imagery (MI) was investigated using functional near-infrared spectroscopy (fNIRS). We used a 31 channel fNIRS system which allows non-invasive monitoring of cerebral oxygenation changes induced by cortical activation. Sixteen healthy subjects (mean-age 24.5 yeas) were recruited and the changes in concentration of hemoglobin were examined during right and left hand finger tapping tasks and kinesthetic MI. To suppress the systemic physiological interference, we developed a preprocessing procedure which prevents over-activated reporting in NIRS-SPM...
2018: Frontiers in Human Neuroscience
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