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"ages", "ckd",

Pranav S Garimella, Ronit Katz, Kushang V Patel, Stephen B Kritchevsky, Chirag R Parikh, Joachim H Ix, Linda F Fried, Anne B Newman, Michael G Shlipak, Tamara B Harris, Mark J Sarnak
BACKGROUND: Studies suggest that in patients with heart failure (HF), high serum erythropoietin is associated with risk of recurrent HF and mortality. Trials of erythropoietin-stimulating agents in persons with kidney disease have also suggested an increased incidence of adverse clinical events. No large studies of which we are aware have evaluated the association of endogenous erythropoietin levels with clinical outcomes in the community-living older adults. METHODS AND RESULTS: Erythropoietin concentration was measured in 2488 participants aged 70-79 years in the Health, Aging and Body Composition Study...
January 2016: Circulation. Heart Failure
L J Lowenstine, R McManamon, K A Terio
The great apes (chimpanzees, bonobos, gorillas, and orangutans) are our closest relatives. Despite the many similarities, there are significant differences in aging among apes, including the human ape. Common to all are dental attrition, periodontitis, tooth loss, osteopenia, and arthritis, although gout is uniquely human and spondyloarthropathy is more prevalent in apes than humans. Humans are more prone to frailty, sarcopenia, osteoporosis, longevity past reproductive senescence, loss of brain volume, and Alzheimer dementia...
March 2016: Veterinary Pathology
L H Chen, C F Mu, C Y Hsu
Background: The prevalence of end-stage renal disease in Taiwan is the highest in the world; haemodialysis accounts for about 7% of the expenditure of the National Health Insurance. Nursing home residents with chronic kidney disease (CKD) have not been identified yet in Taiwan, along with associated risk factors. The objective of this study is to investigate the risk factors of CKD in long-term care facilities in Taiwan and those significantly associated with the presence of CKD. Methods: The nursing home residents who received health examination between January and June 2012, age ≥ 55 years, were enrolled in this study...
December 1, 2015: West Indian Medical Journal
Adam Ogna, Valentina Forni Ogna, José Haba Rubio, Nadia Tobback, Dana Andries, Martin Preisig, Mehdi Tafti, Peter Vollenweider, Gerard Waeber, Pedro Marques-Vidal, Raphaël Heinzer
STUDY OBJECTIVES: To evaluate the association between early stages of chronic kidney disease (CKD) and sleep disordered breathing (SDB), restless legs syndrome (RLS), and subjective and objective sleep quality (SQ). METHODS: Cross-sectional analysis of a general population-based cohort (HypnoLaus). 1,760 adults (862 men, 898 women; age 59.3 (± 11.4) y) underwent complete polysomnography at home. RESULTS: 8.2% of participants had mild CKD (stage 1-2, estimated glomerular filtration rate [eGFR] ≥ 60 mL/min/1...
April 1, 2016: Sleep
Louis S Krane, Matthew G Heavner, Charles Peyton, James T Rague, Ashok K Hemal
INTRODUCTION: In patients with normal estimated renal function before robot-assisted partial nephrectomy (RPN), there is still a risk for de Novo chronic kidney disease (CKD). We assessed the role of dipstick spot proteinuria in risk stratifying patients for CKD progression. MATERIALS AND METHODS: From our prospectively maintained, institutional review board-approved database of patients undergoing RPN, we queried those with estimated glomerular filtration rate (eGFR) >60 and bilateral functional units...
May 2016: Journal of Endourology
Naomi Clyne, Matthias Hellberg, Evangelia Kouidi, Asterios Deligiannis, Peter Höglund
AIM: Cardiac and vascular autonomic neuropathy contributes to increased morbidity and mortality in patients with chronic kidney disease. The aim of this study was to analyze the effects of a decline in glomerular filtration rate (GFR) on heart rate variability (HRV) and nocturnal blood pressure dipping. METHODS: This cross-sectional study comprises 124 patients (46 women, 78 men; age 66 ± 14 years) with chronic kidney disease (CKD) 3-5, not on renal replacement therapy...
December 2016: Nephrology
Joseph Lunyera, Dinushika Mohottige, Megan Von Isenburg, Marc Jeuland, Uptal D Patel, John W Stanifer
BACKGROUND AND OBJECTIVES: Epidemics of CKD of uncertain etiology (CKDu) are emerging around the world. Highlighting common risk factors for CKD of uncertain etiology across various regions and populations may be important for health policy and public health responses. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We searched PubMed, Embase, Scopus and Web of Science databases to identify published studies on CKDu. The search was generated in January of 2015; no language or date limits were used...
March 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
Laëtitia Gorisse, Christine Pietrement, Vincent Vuiblet, Christian E H Schmelzer, Martin Köhler, Laurent Duca, Laurent Debelle, Paul Fornès, Stéphane Jaisson, Philippe Gillery
Aging is a progressive process determined by genetic and acquired factors. Among the latter are the chemical reactions referred to as nonenzymatic posttranslational modifications (NEPTMs), such as glycoxidation, which are responsible for protein molecular aging. Carbamylation is a more recently described NEPTM that is caused by the nonenzymatic binding of isocyanate derived from urea dissociation or myeloperoxidase-mediated catabolism of thiocyanate to free amino groups of proteins. This modification is considered an adverse reaction, because it induces alterations of protein and cell properties...
February 2, 2016: Proceedings of the National Academy of Sciences of the United States of America
George Thomas, Dawei Xie, Hsiang-Yu Chen, Amanda H Anderson, Lawrence J Appel, Shirisha Bodana, Carolyn S Brecklin, Paul Drawz, John M Flack, Edgar R Miller, Susan P Steigerwalt, Raymond R Townsend, Matthew R Weir, Jackson T Wright, Mahboob Rahman
The association between apparent treatment resistant hypertension (ATRH) and clinical outcomes is not well studied in chronic kidney disease. We analyzed data on 3367 hypertensive participants in the Chronic Renal Insufficiency Cohort (CRIC) to determine prevalence, associations, and clinical outcomes of ATRH in nondialysis chronic kidney disease patients. ATRH was defined as blood pressure ≥140/90 mm Hg on ≥3 antihypertensives, or use of ≥4 antihypertensives with blood pressure at goal at baseline visit...
February 2016: Hypertension
Vaibhav Shukla, Rahul Dey, Ashok Chandra, Ritu Karoli, Sachin Khanduri
INTRODUCTION: The last few years have seen a phenomenal increase in the prevalence of chronic kidney disease (CKD). Cardiovascular disease remains the most important cause of death in these patients.The present study was conducted to evaluate endothelial dysfunction in CKD patients as compared with controls. METHODS: Thirty-five patients of CKD and 32 age and sex-matched controls were included in the study. Flow-mediated vasodilatation was assessed in all individuals...
June 2015: Journal of the Association of Physicians of India
Aleksandar Denic, Richard J Glassock, Andrew D Rule
Senescence or normal physiologic aging portrays the expected age-related changes in the kidney as compared to a disease that occurs in some but not all individuals. The microanatomical structural changes of the kidney with older age include a decreased number of functional glomeruli from an increased prevalence of nephrosclerosis (arteriosclerosis, glomerulosclerosis, and tubular atrophy with interstitial fibrosis), and to some extent, compensatory hypertrophy of remaining nephrons. Among the macroanatomical structural changes, older age associates with smaller cortical volume, larger medullary volume until middle age, and larger and more numerous kidney cysts...
January 2016: Advances in Chronic Kidney Disease
Andreas Lammerich, Peter Balcke, Peter Bias, Simone Mangold, Martin Wiesholzer
PURPOSE: The European Medicines Agency recommends limiting the hemoglobin (Hb) concentration to 10 to 12 g/dL in adults with chronic kidney disease (CKD) receiving erythropoiesis-stimulating agents such as epoetin theta. This postauthorization study assessed the incidence and intensity of cardiovascular events, including ischemic stroke, in patients receiving epoetin theta for anemia associated with CKD. A secondary end point was adverse drug reactions, including pure red cell aplasia...
February 2016: Clinical Therapeutics
Alessia Buglioni, Valentina Cannone, S Jeson Sangaralingham, Denise M Heublein, Christopher G Scott, Kent R Bailey, Richard J Rodeheffer, Riccardo Sarzani, John C Burnett
BACKGROUND: We recently reported that normal aldosterone levels are associated with cardiovascular, renal, and metabolic disease in a sample of the US general community (Visit 1). For the current analyses we used the same cohort in a new 4-year follow-up study (Visit 2). METHODS AND RESULTS: We measured aldosterone at Visit 1 and analyzed its predictive role for new diseases at Visit 2 (n=1140). We measured aldosterone at Visit 2 and investigated its associations with disease at Visit 2 (n=1368)...
December 2015: Journal of the American Heart Association
James Goya Heaf
PURPOSE: The purpose of this paper was to review the literature concerning the treatment of chronic kidney disease-mineral bone disorder (CKD-MBD) in the elderly peritoneal dialysis (PD) patient. RESULTS: Chronic kidney disease-mineral bone disorder is a major problem in the elderly PD patient, with its associated increased fracture risk, vascular calcification, and accelerated mortality fracture risk. Peritoneal dialysis, however, bears a lower risk than hemodialysis (HD)...
November 2015: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Mingjun Shi, Brianna Flores, Nancy Gillings, Ao Bian, Han Jun Cho, Shirley Yan, Yang Liu, Beth Levine, Orson W Moe, Ming Chang Hu
AKI confers increased risk of progression to CKD. αKlotho is a cytoprotective protein, the expression of which is reduced in AKI, but the relationship of αKlotho expression level to AKI progression to CKD has not been studied. We altered systemic αKlotho levels by genetic manipulation, phosphate loading, or aging and examined the effect on long-term outcome after AKI in two models: bilateral ischemia-reperfusion injury and unilateral nephrectomy plus contralateral ischemia-reperfusion injury. Despite apparent initial complete recovery of renal function, both types of AKI eventually progressed to CKD, with decreased creatinine clearance, hyperphosphatemia, and renal fibrosis...
August 2016: Journal of the American Society of Nephrology: JASN
Katharina Brück, Vianda S Stel, Giovanni Gambaro, Stein Hallan, Henry Völzke, Johan Ärnlöv, Mika Kastarinen, Idris Guessous, José Vinhas, Bénédicte Stengel, Hermann Brenner, Jerzy Chudek, Solfrid Romundstad, Charles Tomson, Alfonso Otero Gonzalez, Aminu K Bello, Jean Ferrieres, Luigi Palmieri, Gemma Browne, Vincenzo Capuano, Wim Van Biesen, Carmine Zoccali, Ron Gansevoort, Gerjan Navis, Dietrich Rothenbacher, Pietro Manuel Ferraro, Dorothea Nitsch, Christoph Wanner, Kitty J Jager
CKD prevalence estimation is central to CKD management and prevention planning at the population level. This study estimated CKD prevalence in the European adult general population and investigated international variation in CKD prevalence by age, sex, and presence of diabetes, hypertension, and obesity. We collected data from 19 general-population studies from 13 European countries. CKD stages 1-5 was defined as eGFR<60 ml/min per 1.73 m(2), as calculated by the CKD-Epidemiology Collaboration equation, or albuminuria >30 mg/g, and CKD stages 3-5 was defined as eGFR<60 ml/min per 1...
July 2016: Journal of the American Society of Nephrology: JASN
Eiichi Sato, Atsushi Tanaka, Jun-Ichi Oyama, Ayumu Yamasaki, Mitsuhiro Shimomura, Atsushi Hiwatashi, Yoshihiko Ueda, Mayuko Amaha, Mayumi Nomura, Daisuke Matsumura, Tsukasa Nakamura, Koichi Node
AST-120 has been used widely in Japan to slow the deterioration of renal function in patients with chronic kidney disease (CKD) by decreasing uremic toxins. The heart and the kidney are closely related, with cardiorenal interaction being very important. This retrospective study examined whether AST-120 influences the prevalence of dialysis induction, mortality, and cardiac and stroke events in CKD patients. The study included 278 patients diagnosed with chronic renal failure (CKD stage: III-V) in 2006. Of these patients, 128 received AST-120 (6 g/day), while the remaining 150 patients did not...
October 2016: Heart and Vessels
Rubina Naqvi, Muhammed Mubarak, Ejaz Ahmed, Fazal Akhtar, Sajid Bhatti, Anwar Naqvi, Adib Rizvi
INTRODUCTION: Acute kidney injury (AKI) is common in nephro-urological practice. Its incidence, prevalence and etiology vary widely, mainly due to variations in the definitions of AKI. OBJECTIVES: We aim to report the spectrum of glomerular diseases presenting as AKI at a kidney referral center in Pakistan. PATIENTS AND METHODS: An observational cohort of patients identified as having AKI which was defined according to RIFLE criteria, with normal size, non-obstructed kidneys on ultrasonography, along with active urine sediment, edema and new onset hypertension...
2015: Journal of Renal Injury Prevention
Gianluca Trifirò, Fabrizio Parrino, Valeria Pizzimenti, Francesco Giorgianni, Janet Sultana, Marco Muscianisi, Chiara Troncone, Daniele U Tari, Vincenzo Arcoraci, Domenico Santoro, Giusi Russo, Viviana Lacava, Achille P Caputi
BACKGROUND AND OBJECTIVES: Diabetes mellitus in patients with chronic kidney disease (CKD) is known as diabetic kidney disease (DKD). Pharmacological management of DKD is challenging due to reduced renal excretion of some antidiabetic drugs. The aim of this population-based study was to explore antidiabetic drug use in DKD patients from Southern Italy. METHODS: The Arianna database from Caserta Local Health Unit was used. Diabetic patients with incident CKD [first diagnosis date: index date (ID)] were identified by searching for specific ICD9-CM codes among hospital discharge diagnoses/procedures and/or indication of use associated with drug prescriptions...
March 2016: Clinical Drug Investigation
Il Suk Sohn, Chong-Jin Kim, Byung-Hee Oh, Taek-Jong Hong, Chang-Gyu Park, Byung-Soo Kim, Woo-Baek Chung
BACKGROUND: This study was to evaluate the efficacy and safety of triple fixed-dose combination (FDC) therapy with olmesartan medoxomil (OM) 20 mg, amlodipine (AML) 5 mg, and hydrochlorothiazide (HCTZ) 12.5 mg (OM/AML/HCTZ 20/5/12.5) in Korean patients with moderate hypertension not controlled with dual FDC therapy (OM/HCTZ 20/12.5). METHODS: In this multicenter, randomized, double-blind, parallel-group study, Korean patients aged 20 to 75 years with stage 2 hypertension who had a mean seated diastolic blood pressure (msDBP) ≥100 mmHg were enrolled when their BP was uncontrolled [mean seated systolic BP (msSBP)/msDBP >140/90 mmHg or msSBP/msDBP >130/80 mmHg with diabetes or chronic kidney disease] with 4-week dual FDC therapy (OM/HCTZ 20/12...
April 2016: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
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