Sebastiaan C Goulooze, Swantje Völler, Pyry A J Välitalo, Elisa A M Calvier, Leon Aarons, Elke H J Krekels, Catherijne A J Knibbe
In covariate (sub)models of population pharmacokinetic models, most covariates are normalized to the median value; however, for body weight, normalization to 70 kg or 1 kg is often applied. In this article, we illustrate the impact of normalization weight on the precision of population clearance (CLpop ) parameter estimates. The influence of normalization weight (70, 1 kg or median weight) on the precision of the CLpop estimate, expressed as relative standard error (RSE), was illustrated using data from a pharmacokinetic study in neonates with a median weight of 2...
March 23, 2018: Clinical Pharmacokinetics