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MFG-E8

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https://www.readbyqxmd.com/read/28653875/mfg-e8-overexpression-promotes-colorectal-cancer-progression-via-akt-mmps-signalling
#1
Qiujie Zhao, Lin Xu, Xiaoyan Sun, Kai Zhang, Huimin Shen, Yanan Tian, Fengkai Sun, Yanqing Li
Several studies have revealed that MFG-E8 (milk fat globule-epidermal growth factor 8) is related to tumour development and progression. However, the relationship between MFG-E8 expression and metastasis in colorectal cancer patients and the role of MFG-E8 in colorectal cancer invasion and progression remain unknown. In this study, we performed immunohistochemistry and quantitative real-time polymerase chain reaction to assess MFG-E8 expression in colorectal cancer and adjacent non-cancerous tissues. Colorectal cancer RNAseq data from The Cancer Genome Atlas project were downloaded and MFG-E8 expression was analysed...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28612258/downregulated-glia-interplay-and-increased-mirna-155-as-promising-markers-to-track-als-at-an%C3%A2-early-stage
#2
Carolina Cunha, Catarina Santos, Cátia Gomes, Adelaide Fernandes, Alexandra Marçal Correia, Ana Maria Sebastião, Ana Rita Vaz, Dora Brites
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of unknown cause. Absence of specific targets and biomarkers compromise the development of new therapeutic strategies and of innovative tools to stratify patients and assess their responses to treatment. Here, we investigate changes in neuroprotective-neuroinflammatory actions in the spinal cord of SOD1 (G93A) mice, at presymptomatic and symptomatic stages to identify stage-specific biomarkers and potential targets. Results showed that in the presymptomatic stage, there are alterations in both astrocytes and microglia, which comprise decreased expression of GFAP and S100B and upregulation of GLT-1, as well as reduced expression of CD11b, M2-phenotype markers, and a set of inflammatory mediators...
June 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28601327/milk-fat-globule-epidermal-growth-factor-factor-viii-attenuates-sepsis-induced-acute-kidney-injury
#3
Cindy Cen, Monowar Aziz, Weng-Lang Yang, Mian Zhou, Jeffrey M Nicastro, Gene F Coppa, Ping Wang
BACKGROUND: Acute kidney injury (AKI) is most commonly caused by sepsis in critically ill patients, and it is associated with high morbidity and mortality. The pathophysiology of sepsis-induced AKI is generally accepted to include direct inflammatory injury, endothelial cell dysfunction, and apoptosis. Milk fat globule-epidermal growth factor-factor VIII (MFG-E8) is a secretory glycoprotein with a known role in the enhancement of apoptotic cell clearance and regulation of inflammation...
June 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28526301/mfg-e8-reprogramming-of-macrophages-promotes-wound-healing-by-increased-bfgf-production-and-fibroblast-functions
#4
Patrick Laplante, Frédéric Brillant-Marquis, Marie-Joëlle Brissette, Benjamin Joannette-Pilon, Romain Cayrol, Victor Kokta, Jean-François Cailhier
Macrophages are essential for tissue repair. They have a crucial role in cutaneous wound healing, participating actively in the inflammation phase of the process. Unregulated macrophage activation may, however, represent a source of excessive inflammation leading to abnormal wound healing and hypertrophic scars. Our research group has demonstrated that apoptotic endothelial and epithelial cells secrete Milk Fat Globule Epidermal Growth Factor-8 (MFG-E8), which has the ability to reprogram macrophages from a M1 (pro-inflammatory) to a M2 (anti-inflammatory pro-repair) phenotype...
May 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28483607/interleukin-17a-promotes-lung-tumor-progression-through-neutrophil-attraction-to-tumor-sites-and-mediating-resistance-to-pd-1-blockade
#5
Esra A Akbay, Shohei Koyama, Yan Liu, Ruben Dries, Lauren E Bufe, Michael Silkes, Md Maksudul Alam, Dillon M Magee, Robert Jones, Masahisa Jinushi, Meghana Kulkarni, Julian Carretero, Xiaoen Wang, Tiquella Warner-Hatten, Jillian D Cavanaugh, Akio Osa, Atsushi Kumanogoh, Gordon J Freeman, Mark M Awad, David C Christiani, Raphael Bueno, Peter S Hammerman, Glenn Dranoff, Kwok-Kin Wong
INTRODUCTION: Proinflammatory cytokine interleukin-17A (IL-17A) is overexpressed in a subset of patients with lung cancer. We hypothesized that IL-17A promotes a protumorigenic inflammatory phenotype and inhibits antitumor immune responses. METHODS: We generated bitransgenic mice expressing a conditional IL-17A allele along with conditional Kras(G12D) and performed immune phenotyping of mouse lungs, a survival analysis, and treatment studies with antibodies either blocking programmed cell death 1 (PD-1) or IL-6 or depleting neutrophils...
May 6, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28466190/microglia-endocytose-amyloid-%C3%AE-through-the-binding-of-transglutaminase-2-and-milk-fat-globule-egf-factor-8-protein
#6
Kenji Kawabe, Katsura Takano, Mitsuaki Moriyama, Yoichi Nakamura
Activation of glial cells has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Aggregation of amyloid β (Aβ) is profusely observed as characteristic pathology in AD brain. In our previous study using microglial cell line BV-2, tissue-type transglutaminase (TG2) was found to be involved in phagocytosis (Kawabe et al., in Neuroimmunomodulation 22(4):243-249, 2015; Kawabe et al., Neurochem Res 2017). In the present study, we examined whether TG2 and milk fat globule EGF factor 8 protein (MFG-E8), an adaptor protein promotes macrophage to engulf apoptotic cells, were involved in Aβ endocytosis...
May 3, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28398652/brucella-abortus-activated-microglia-induce-neuronal-death-through-primary-phagocytosis
#7
Ana M Rodríguez, M Victoria Delpino, M Cruz Miraglia, Miriam M Costa Franco, Paula Barrionuevo, Vida A Dennis, Sergio C Oliveira, Guillermo H Giambartolomei
Inflammation has long been implicated as a contributor to pathogenesis in neurobrucellosis. Many of the associated neurocognitive symptoms of neurobrucellosis may be the result of neuronal dysfunction resulting from the inflammatory response induced by Brucella abortus infection in the central nervous system. In this manuscript, we describe an immune mechanism for inflammatory activation of microglia that leads to neuronal death upon B. abortus infection. B. abortus was unable to infect or harm primary cultures of mouse neurons...
April 11, 2017: Glia
https://www.readbyqxmd.com/read/28343695/treatment-with-milk-fat-globule-epidermal-growth-factor-factor-8-mfg-e8-reduces-inflammation-and-lung-injury-in-neonatal-sepsis
#8
Laura W Hansen, Weng Lang Yang, Alexandra C Bolognese, Asha Jacob, Tracy Chen, Jose M Prince, Jeffrey M Nicastro, Gene F Coppa, Ping Wang
BACKGROUND: Sepsis remains one of the leading causes of infant death worldwide. It is characterized by uncontrolled inflammatory responses due to proven bacterial infection. Despite improvement in supportive care and the availability of effective antibiotics, no specific therapy targeting the dysregulated inflammatory response is available for neonatal sepsis. Milk fat globule epidermal growth factor-factor 8 (MFG-E8) is a secretory glycoprotein abundantly present in human milk. MFG-E8 suppresses the systemic inflammatory responses in adult murine injury models by improving the clearance of dying cells...
August 2017: Surgery
https://www.readbyqxmd.com/read/28302404/mesenchymal-stem-cells-derived-mfg-e8-accelerates-diabetic-cutaneous-wound-healing
#9
Akihiko Uchiyama, Sei-Ichiro Motegi, Akiko Sekiguchi, Chisako Fujiwara, Buddhini Perera, Sachiko Ogino, Yoko Yokoyama, Osamu Ishikawa
BACKGROUND: Diabetic wounds are intractable due to complex factors, such as the inhibition of angiogenesis, dysfunction of phagocytosis by macrophages and abnormal inflammatory responses. It is recognized that mesenchymal stem cells (MSCs) promote wound healing in diabetic mice. We previously demonstrated that MSCs produce large amounts of MFG-E8. OBJECT: The objective was to ascertain the role of MSCs-derived MFG-E8 in murine diabetic wounds. METHODS: MFG-E8 WT/KO MSCs or rMFG-E8 were subcutaneously injected around the wound in diabetic db/db mice, and wound areas were analyzed...
June 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28296340/lactadherin-is-a-candidate-oviduct-lewis-x-trisaccharide-receptor-on-porcine-spermatozoa
#10
E Silva, D Frost, L Li, N Bovin, D J Miller
A recent study has demonstrated that porcine spermatozoa recognize with high affinity carbohydrate structures containing Lewis X motifs. Sperm adhesion to Lewis X is proposed to mediate sperm binding to the oviduct epithelium to form a reservoir. The objective of this study was to identify Lewis X-binding proteins from porcine spermatozoa as candidate receptors for oviduct glycans. To identify low-abundance proteins typically masked by proteins originating from seminal fluid, Lewis X candidate receptors were enriched from cauda epididymal boar spermatozoa...
May 2017: Andrology
https://www.readbyqxmd.com/read/28266034/elevated-serum-mfg-e8-level-is-possibly-associated-with-the-presence-of-high-intensity-cerebral-lesions-on-magnetic-resonance-imaging-in-patients-with-systemic-lupus-erythematosus
#11
Chikako Kishi, Sei-Ichiro Motegi, Osamu Ishikawa
Human milk fat globule-EGF factor 8 (MFG-E8), also known as lactadherin, is a secreted glycoprotein that plays essential roles in the clearance of apoptotic cells and angiogenesis. It has been reported that serum MFG-E8 levels are higher in systemic lupus erythematosus (SLE) patients compared with in healthy controls; however, a previous study reported no correlation between serum MFG-E8 levels and SLE disease activity. The objective of this study was to assess serum MFG-E8 levels and their clinical associations in patients with SLE...
March 7, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28207941/milk-fat-globule-epidermal-growth-factor-8-inhibits-periodontitis-in-non-human-primates-and-its-gingival-crevicular-fluid-levels-can-differentiate-periodontal-health-from-disease-in-humans
#12
Tetsuhiro Kajikawa, Fatimah Meshikhes, Tomoki Maekawa, Evlambia Hajishengallis, Kavita B Hosur, Toshiharu Abe, Kevin Moss, Triantafyllos Chavakis, George Hajishengallis
AIM: We have previously shown that the secreted glycoprotein milk fat globule epidermal growth factor 8 (MFG-E8) has anti-inflammatory and anti-osteoclastogenic properties. Our objective was to investigate the potential of MFG-E8 as a diagnostic or therapeutic agent in periodontitis. MATERIALS AND METHODS: Periodontitis was induced in non-human primates (NHPs) by placing ligatures around posterior teeth on both halves of the mandible for a split-mouth design: one side was treated with MFG-E8-Fc and the other with Fc control...
May 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28195210/cigarette-smoke-attenuates-phagocytic-ability-of-macrophages-through-down-regulating-milk-fat-globule-egf-factor-8-mfg-e8-expressions
#13
Yueqin Wang, Guangwei Luo, Jie Chen, Rui Jiang, Jianhua Zhu, Na Hu, Wei Huang, Guilian Cheng, Min Jia, Bingtao Su, Nian Zhang, Tianpen Cui
Chronic obstructive pulmonary disease (COPD) is one of the most common inflammatory diseases resulting from habitual smoking. Impaired clearance of apoptotic cell by airway macrophages contributes to lung inflammation. Milk fat globule-EGF factor 8 (MFG-E8), as a link between apoptotic cells and phagocytes, facilitates clearance of apoptotic cells and attenuates inflammation. We sought to investigate altered expression and potential role of MFG-E8 in COPD. In this study, apoptosis was increased and the level of MFG-E8 was decreased while HMGB1 expression was increased in lung tissues of CS-exposed mice...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28108420/neutrophil-derived-microparticles-increase-mortality-and-the-counter-inflammatory-response-in-a-murine-model-of-sepsis
#14
Bobby L Johnson, Emily F Midura, Priya S Prakash, Teresa C Rice, Natalia Kunz, Kathrin Kalies, Charles C Caldwell
Although advances in medical care have significantly improved sepsis survival, sepsis remains the leading cause of death in the ICU. This is likely due to a lack of complete understanding of the pathophysiologic mechanisms that lead to dysfunctional immunity. Neutrophil derived microparticles (NDMPs) have been shown to be the predominant microparticle present at infectious and inflamed foci in human models, however their effect on the immune response to inflammation and infection is sepsis has not been fully elucidated...
January 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28096298/mfg-e8-derived-peptide-attenuates-adhesion-and-migration-of-immune-cells-to-endothelial-cells
#15
Yohei Hirano, Weng-Lang Yang, Monowar Aziz, Fangming Zhang, Barbara Sherry, Ping Wang
Milk fat globule-epidermal growth factor-factor 8 (MFG-E8) plays an immunomodulatory role in inflammatory diseases. MFG-E8-derived short peptide (MSP68) greatly reduces neutrophil infiltration and injury in the lung during sepsis. In this study, we examined the effect of MSP68 on chemotaxis of various immune cells and its regulatory mechanism. Bone marrow-derived neutrophils (BMDNs) from C57BL/6 mice, human monocyte THP-1 cell line, and human T lymphocyte Jurkat cell line were used for adhesion and migration assays using a Transwell method in the presence of MSP68...
May 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28089751/reduced-serum-milk-fat-globule-epidermal-growth-factor-8-mfg-e8-concentrations-are-associated-with-an-increased-risk-of-microvascular-complications-in-patients-with-type-2-diabetes
#16
Guohua Sun, Juxiang Liu, Guanghao Xia, Lijuan Zhang, Yonghong Li, Zubang Zhou, Yaya Lv, Suhong Wei, Jing Liu, Jinxing Quan
BACKGROUND: The association between serum milk fat globule-epidermal growth factor 8 (MFG-E8) concentrations and vascular complications in T2DM remains unclear. METHODS: A total of 149 patients with T2DM were included. The serum concentrations of MFG-E8, glycosylated hemoglobin (HbA1c), and high-sensitivity C-reactive protein (hs-CRP) were measured. RESULTS: There was no significant difference in serum MFG-E8 concentrations between the T2DM group and the T2DM with subclinical atherosclerosis (AS) group (615...
March 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28067023/elevated-serum-milk-fat-globule-epidermal-growth-factor-8-levels-in-type-2-diabetic-patients-are-suppressed-by-overweight-or-obese-status
#17
Yuanyuan Li, Wenzhuo Ran, Jiaqiang Zhang, Shi Chen, Yihang Li, Deng Luo, Chen Wang, Weiping Jia
Inflammation is the most important link between obesity and type 2 diabetes (T2D). Although milk fat globule-epidermal growth factor 8 (MFG-E8) is a key mediator in anti-inflammatory responses, its role in obesity and diabetes is not yet completely understood. We aimed to measure MFG-E8 serum levels and to explore the role of MFG-E8 in obesity and T2D. Fasting serum MFG-E8 levels were quantified by enzyme-linked immunosorbent assay for 168 individuals, whose oral glucose tolerance test was conducted, and levels of inflammatory factors, including tumor necrosis factor-α (TNF-α) and C-reactive protein, were measured...
February 2017: IUBMB Life
https://www.readbyqxmd.com/read/28035763/circulating-milk-fat-globule-epidermal-growth-factor-8-levels-are-increased-in-pregnancy-and-gestational-diabetes-mellitus
#18
Yuanyuan Li, Wenzhuo Ran, Jiaqiang Zhang, Shi Chen, Yihang Li, Deng Luo, Chen Wang, Weiping Jia
AIMS/INTRODUCTION: Milk fat globule-epidermal growth factor 8 (MFG-E8) is the key mediator in anti-inflammatory responses that facilitate phagocytosis of apoptotic cells, and play an essential role in type 2 diabetes and pregnancy, both of which are under a low-grade inflammatory state. However, the action of MFG-E8 in gestational diabetes mellitus (GDM) is unclear. We measured plasma MFG-E8 levels in pregnancy and GDM for the first time, and elucidated possible relationships between its plasma levels and various metabolic parameters...
July 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27918308/cardiac-myofibroblast-engulfment-of-dead-cells-facilitates-recovery-after-myocardial-infarction
#19
Michio Nakaya, Kenji Watari, Mitsuru Tajima, Takeo Nakaya, Shoichi Matsuda, Hiroki Ohara, Hiroaki Nishihara, Hiroshi Yamaguchi, Akiko Hashimoto, Mitsuho Nishida, Akiomi Nagasaka, Yuma Horii, Hiroki Ono, Gentaro Iribe, Ryuji Inoue, Makoto Tsuda, Kazuhide Inoue, Akira Tanaka, Masahiko Kuroda, Shigekazu Nagata, Hitoshi Kurose
Myocardial infarction (MI) results in the generation of dead cells in the infarcted area. These cells are swiftly removed by phagocytes to minimize inflammation and limit expansion of the damaged area. However, the types of cells and molecules responsible for the engulfment of dead cells in the infarcted area remain largely unknown. In this study, we demonstrated that cardiac myofibroblasts, which execute tissue fibrosis by producing extracellular matrix proteins, efficiently engulf dead cells. Furthermore, we identified a population of cardiac myofibroblasts that appears in the heart after MI in humans and mice...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27866791/mesenchymal-stem-cells-the-roles-and-functions-in-cutaneous-wound-healing-and-tumor-growth
#20
REVIEW
Sei-Ichiro Motegi, Osamu Ishikawa
Mesenchymal stem cells (MSCs) are bone marrow-derived non-hematopoietic progenitor cells. MSCs are able to differentiate into various types of cells, including chondrocytes, adipocytes, osteocytes, myocytes, endothelial cells, and keratinocytes. There is increasing evidence that MSCs might be located external to the vasculature, and that perivascular cells in the skin, generally called as "pericytes", might include MSCs. It has been suggested that MSCs localized around blood vessels might migrate into wounds and contribute to the restoration of injured tissues...
November 11, 2016: Journal of Dermatological Science
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