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https://www.readbyqxmd.com/read/28212400/surveys-of-public-knowledge-and-attitudes-with-regard-to-antibiotics-in-poland-did-the-european-antibiotic-awareness-day-campaigns-change-attitudes
#1
Beata Mazińska, Izabela Strużycka, Waleria Hryniewicz
BACKGROUND: Antimicrobial resistance is a global public health problem. Monitoring the level of knowledge regarding antibiotics is a part of the European Union Community strategy against antimicrobial resistance. OBJECTIVE: To assess knowledge by the general public in Poland regarding antibiotics, AMR, and the impact of the European Antibiotic Awareness Day campaigns. METHODS: The repeated cross-sectional study was developed and carried out among the general public in Poland (in 5 waves between 2009 and 2011, embracing a total of 5004 respondents)...
2017: PloS One
https://www.readbyqxmd.com/read/28209468/characteristics-of-nontyphoidal-salmonella-gastroenteritis-in-taiwanese-children-a-9-year-period-retrospective-medical-record-review
#2
Yeh-Ting Hung, Chorng-Jang Lay, Chun-Lung Wang, Malcolm Koo
Nontyphoidal Salmonella is among the most common causes of acute pediatric gastroenteritis in Taiwan. It is important to study antibiotic resistance patterns in nontyphoidal Salmonella isolated from children. Therefore, the objective of this study was to investigate the prevalence of serogroups and susceptibility to antimicrobial nontyphoidal Salmonella isolated from Taiwanese children with gastroenteritis. A retrospective review of the medical records of patients aged under 18 years with a diagnosis of acute gastroenteritis at a regional hospital located in southern Taiwan from August 2000 to August 2009 was conducted...
February 13, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28174422/antarlides-f-h-new-members-of-the-antarlide-family-produced-by-streptomyces-sp-bb47
#3
Shun Saito, Takahiro Fujimaki, Watanalai Panbangred, Ryuichi Sawa, Yasuhiro Igarashi, Masaya Imoto
Castration-resistant prostate cancer (CRPC) is the most aggressive form of this disease. CRPC remains dependent on androgen receptor (AR) signaling. Therefore, a novel AR antagonist, enzalutamide, is used clinically for the treatment of men with metastatic CRPC. However, enzalutamide-resistant AR has appeared, and a new type of AR antagonist is desired. Previously, in the course of screening for a new type of AR antagonist, we isolated a series of compounds, designated antarlides A-E, that share a novel 22-membered-ring macrocyclic structure and are produced by Streptomyces sp...
February 8, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28150580/biocompatible-biodegradable-polymeric-antibacterial-nanoparticles-for-enhancing-the-effects-of-the-third-generation-cephalosporin-against-resistant-bacteria
#4
Sana Mushtaq, Jawad Akbar Khan, Faiz Rabbani, Usman Latif, Muhammad Arfan, Muhammad Arfat Yameen
PURPOSE: The present study attempted to enhance the antibacterial activity of ceftriaxone with biodegradable polymer against Gram-positive (MRSA) and -negative (E. coli) bacteria. METHODOLOGY: MRSA and E. coli were collected and identified by biochemical and molecular tests. Blank and ceftriaxone loaded CNPs were prepared by ionic gelation method. The in-vitro antibiotic susceptibility studies were performed by disc diffusion, agar well plate method, E-test and time kill assay...
February 1, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28148226/trends-in-antimicrobial-resistance-and-empiric-antibiotic-therapy-of-bloodstream-infections-at-a-general-hospital-in-mid-norway-a-prospective-observational-study
#5
Arne Mehl, Bjørn Olav Åsvold, Angela Kümmel, Stian Lydersen, Julie Paulsen, Ingvild Haugan, Erik Solligård, Jan Kristian Damås, Stig Harthug, Tom-Harald Edna
BACKGROUND: The occurrence of bloodstream infection (BSI) and antimicrobial resistance have been increasing in many countries. We studied trends in antimicrobial resistance and empiric antibiotic therapy at a medium-sized general hospital in Mid-Norway. METHODS: Between 2002 and 2013, 1995 prospectively recorded episodes of BSI in 1719 patients aged 16-99 years were included. We analyzed the antimicrobial non-susceptibility according to place of acquisition, site of infection, microbe group, and time period...
February 2, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28144154/occurrence-of-extended-spectrum-and-ampc-%C3%AE-lactamases-in-multiple-drug-resistant-salmonella-isolates-from-clinical-samples-in-lagos-nigeria
#6
K O Akinyemi, Bamidele Abiodun Iwalokun, Akeeb O Bola Oyefolu, C O Fakorede
PURPOSE: Salmonella spp. are important foodborne pathogens exhibiting increasing resistance to antimicrobial drugs. Resistance to broad-spectrum β-lactams, mediated by extended-spectrum β-lactamase (ESBL) and AmpC β-lactamase enzymes is fast spreading and has had negative impacts on the clinical outcomes, particularly on third-generation cephalosporins. This study investigated the carriage of AmpC gene among multidrug-resistant Salmonella spp. from Lagos, Nigeria. METHODS: Forty Salmonella spp...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28137937/antibiotic-susceptibility-and-molecular-analysis-of-invasive-haemophilus-influenzae-in-canada-2007-to-2014
#7
Raymond S W Tsang, Michelle Shuel, Kathleen Whyte, Linda Hoang, Gregory Tyrrell, Greg Horsman, John Wylie, Frances Jamieson, Brigitte Lefebvre, David Haldane, Rita R Gad, Gregory J German, Robert Needle
BACKGROUND: Previously we studied the antibiotic susceptibility of invasive Haemophilus influenzae collected in Canada from 1990 to 2006 and characterized isolates by serotype, MLST and ftsI gene sequencing for significant PBP3 mutations. OBJECTIVES: To provide an update based on isolates collected from 2007 to 2014. METHODS: A total of 882 case isolates were characterized by serotype using slide agglutination and PCR. MLST was carried out to determine ST...
January 30, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28116124/the-rapid-detection-of-cefotaxime-resistant-enterobacteriaceae-by-hplc
#8
Andrew M Robinson, Natalie J Medlicott, James E Ussher
AIM: Antibiotic resistance mediated by extended-spectrum β-lactamases (ESBL) and AmpC β-lactamases is widespread and increasingly common, often rendering empiric antibiotic therapy ineffective. In septicemia, delays in initiating effective antibiotic therapy are associated with worse clinical outcomes. With current phenotypic antimicrobial susceptibility testing methods, there is often a delay of 18-24 h before the susceptibility of an isolate is known. RESULTS: Using an HPLC assay, breakdown of the third-generation cephalosporin cefotaxime by ESBL- and AmpC- β-lactamase-producing organisms could be detected within 90 min with 86...
December 2016: Future Science OA
https://www.readbyqxmd.com/read/28108677/in-vitro-susceptibility-to-19-agents-other-than-%C3%AE-lactams-among-third-generation-cephalosporin-resistant-enterobacteriaceae-recovered-on-hospital-admission
#9
A Mischnik, P Baumert, A Hamprecht, A M Rohde, S Peter, S Feihl, J Knobloch, H Gölz, A Kola, B Obermann, C Querbach, M Willmann, F Gebhardt, E Tacconelli, P Gastmeier, H Seifert, W V Kern
OBJECTIVES: As part of the multicentre Antibiotic Therapy Optimisation Study, MIC values of 19 non-β-lactam agents were determined for third-generation cephalosporin-resistant Escherichia coli, Klebsiella species and Enterobacter species (3GCREB) isolates collected in German hospitals. METHODS: A total of 328 E. coli, 35 Klebsiella spp. (1 Klebsiella oxytoca and 34 Klebsiella pneumoniae) and 16 Enterobacter spp. (1 Enterobacter aerogenes and 15 Enterobacter cloacae) isolates were submitted to broth microdilution antimicrobial susceptibility testing with the MICRONAUT system...
January 19, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28099061/iodometric-and-molecular-detection-of-esbl-production-among-clinical-isolates-of-e-coli-fingerprinted-by-eric-pcr-the-first-egyptian-report-declares-the-emergence-of-e-coli-o25b-st131clone-harboring-blages
#10
Mohamed F El-Badawy, Wael M Tawakol, Ibrahim A Maghrabi, Moselhy S Mansy, Mohamed M Shohayeb, Mohammed S Ashour
The extensive use of β-lactam antibiotics has led to emergence and spread of extended-spectrum β-lactamases (ESBLs). This study was conducted to investigate the prevalence of 7 different ESBL genes (blaTEM, blaSHV, blaCTX-M, blaVEB, blaPER, blaGES, and blaOXA-10) and O25b-ST131 high-risk clone among 61 clinical isolates of Escherichia coli. Also, one broad-spectrum β-lactamase (blaOXA-1) was investigated. This study was also constructed to evaluate iodometric overlay method in detection of ESBL production...
January 18, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28088587/late-onset-neonatal-sepsis-in-arab-states-in-the-gulf-region-two-year-prospective-study
#11
Majeda S Hammoud, Abdullah Al-Taiar, Sameer Y Al-Abdi, Hussain Bozaid, Anwar Khan, Laila M AlMuhairi, Moghis Ur Rehman
OBJECTIVES: This study aimed to investigate the incidence of late-onset sepsis (LOS) in neonatal intensive care units (NICUs) in Arab states in the Gulf region and to describe the main causative organisms and their antibiotic resistance. METHODS: This observational prospective cohort study was conducted over a 2-year period in five NICUs in Kuwait, Saudi Arabia, and the United Arab Emirates. LOS was defined as the growth of a single potentially pathogenic organism from blood or cerebrospinal fluid in infants >3days of age with clinical and laboratory findings consistent with infection...
January 11, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28087318/etiologies-of-community-onset-urinary-tract%C3%A2-infections-requiring-hospitalization-and%C3%A2-antimicrobial-susceptibilities-of%C3%A2-causative-microorganisms
#12
Chih-Chien Chiu, Tzu-Chao Lin, Rui-Xin Wu, Ya-Sung Yang, Po-Jen Hsiao, Yi Lee, Jung-Chung Lin, Feng-Yee Chang
BACKGROUND: Community-onset urinary tract infections (CoUTIs) are the most common bacterial infections, and a decline in antibiotic susceptibility causes many clinical challenges. Adequate empiric antibiotic treatment can decrease unnecessary hospital stays and complications, while reducing the antimicrobial resistance progression. METHODS: From October 2014 to April 2015, we retrospectively enrolled patients who were at least 18 years old and required hospitalization for CoUTIs...
December 18, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28077671/impact-of-long-term-care-facility-residence-on-the-antibiotic-resistance-of-urinary-tract-escherichia-coli-and-klebsiella
#13
Alicia Rosello, Andrew C Hayward, Susan Hopkins, Carolyne Horner, Dean Ironmonger, Peter M Hawkey, Sarah R Deeny
BACKGROUND: Long-term care facilities (LTCFs) are thought to be important reservoirs of antimicrobial-resistant (AMR) bacteria; however, there is no routine surveillance of resistance in LTCF residents, or large population-based studies comparing AMR in LTCFs with the community, so the relative burden of AMR in LTCFs remains unknown. OBJECTIVES: To compare the frequency of antibiotic resistance of urinary tract bacteria from residents of LTCFs for the elderly and adults aged 70 years or older living in the community...
January 10, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28073968/variants-of-abgri3-carrying-the-arma-gene-in-extensively-antibiotic-resistant-acinetobacter-baumannii-from-singapore
#14
Grace A Blackwell, Kathryn E Holt, Stephen D Bentley, Li Yang Hsu, Ruth M Hall
OBJECTIVES: To investigate the context of the ribosomal RNA methyltransferase gene armA in carbapenem-resistant global clone 2 (GC2) Acinetobacter baumannii isolates from Singapore. METHODS: Antibiotic resistance was determined using disc diffusion; PCR was used to identify resistance genes. Whole genome sequences were determined and contigs were assembled and ordered using PCR. Resistance regions in unsequenced isolates were mapped. RESULTS: Fifteen GC2 A...
January 10, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28061852/the-occurrence-of-esbl-producing-escherichia-coli-carrying-aminoglycoside-resistance-genes-in-urinary-tract-infections-in-saudi-arabia
#15
Essam J Alyamani, Anamil M Khiyami, Rayan Y Booq, Majed A Majrashi, Fayez S Bahwerth, Elena Rechkina
BACKGROUND: The infection and prevalence of extended-spectrum β-lactamases (ESBLs) is a worldwide problem, and the presence of ESBLs varies between countries. In this study, we investigated the occurrence of plasmid-mediated ESBL/AmpC/carbapenemase/aminoglycoside resistance gene expression in Escherichia coli using phenotypic and genotypic techniques. METHODS: A total of 58 E. coli isolates were collected from hospitals in the city of Makkah and screened for the production of ESBL/AmpC/carbapenemase/aminoglycoside resistance genes...
January 6, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28036314/etiology-of-early-onset-septicemia-among-neonates-at-the-university-college-hospital-ibadan-nigeria
#16
Abimbola Ellen Akindolire, Olukemi Tongo, Hannah Dada-Adegbola, Olusegun Akinyinka
INTRODUCTION: Neonatal septicemia remains a major cause of newborn deaths in developing countries. Its burden is further compounded by the emergence of multidrug-resistant pathogens, which is related to a lack of antibiotic protocols resulting in unrestricted use of antibiotics. The absence of reliable antibiotic sensitivity testing makes the formulation of antibiotic guidelines and judicious use of antibiotics difficult. This study sought to identify the current bacterial agents associated with early onset septicemia (EOS; age <72 hours) and their antibiotic susceptibility patterns among neonates at the University College Hospital, Ibadan, Nigeria...
December 30, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28036312/antimicrobial-resistance-of-selected-invasive-bacteria-in-a-tertiary-care-center-results-of-a-prospective-surveillance-study
#17
Olivera Djuric, Snezana Jovanovic, Branka Stosovic, Tanja Tosic, Milica Jovanovic, Ljiljana Markovic-Denic
INTRODUCTION: We aimed to report the distribution and resistance patterns of eight invasive clinically relevant bacteria surveyed in the Clinical Center of Serbia (CCS) in Belgrade. METHODOLOGY: A total of 477 clinical blood stream isolates of Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecium, Enterococcus faecalis, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter spp. were collected in the period from January to December 2013...
December 30, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27999665/estimating-the-morbidity-and-mortality-associated-with-infections-due-to-multidrug-resistant-bacteria-mdrb-france-2012
#18
M Colomb-Cotinat, J Lacoste, C Brun-Buisson, V Jarlier, B Coignard, S Vaux
BACKGROUND: A study based on 2007 data estimated that 386,000 infections due to multidrug-resistant bacteria (MDRB) occurred in Europe that year and 25,000 patients died from these infections. Our objective was to estimate the morbidity and mortality associated with these infections in France. METHODS: The MDRB considered were methicillin-resistant Staphylococcus aureus (MRSA), glycopeptide-resistant enterococci, third-generation cephalosporin-resistant (3GC-R) Escherichia coli and Klebsiella pneumoniae, carbapenem-resistant Klebsiella pneumoniae, Acinetobacter spp...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27981386/-non-viral-sexually-transmitted-infections-epidemiology-clinical-manifestations-diagnostics-and-therapy-part%C3%A2-1-gonococci
#19
REVIEW
P Nenoff, A Manos, I Ehrhard, C Krüger, U Paasch, P Helmbold, W Handrick
Approximately 1 million people are infected per day worldwide by one or more sexually transmitted infections (STI) as estimated by the World Health Organization (WHO). Gonorrhoea represents an almost exclusively sexually transmitted infection, which predominantly affects mucous membranes of the genitourinary tract. Extragenital localization of infections is also possible, e. g. in the anorectal region. Currently, only syphilis and human immunodeficiency virus (HIV) are notifiable diseases according to the Infection Protection Act in Germany...
December 15, 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27964724/antimicrobial-resistance-pattern-a-report-of-microbiological-cultures-at-a-tertiary-hospital-in-tanzania
#20
Nyambura Moremi, Heike Claus, Stephen E Mshana
BACKGROUND: Antimicrobial resistance has been declared by the World Health Organization as a threat to the public health. The aim of this study was to analyze antimicrobial resistance patterns of the common pathogens occurring at the Bugando Medical Centre (BMC), Mwanza, Tanzania to provide data for antimicrobial stewardship programmes. METHODS: A total of 3330 microbiological culture results scripts representing non-repetitive specimens reported between June 2013 and May 2015 were retrieved and analyzed for pathogens and their susceptibility patterns using STATA-11 software...
December 13, 2016: BMC Infectious Diseases
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