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JOURNAL ARTICLE
Costanza Pellegrini, Charlotte Duesmann, Tobias Rheude, Amelie Berg, Hector A Alvarez-Covarrubias, Teresa Trenkwalder, N Patrick Mayr, Friederike Schürmann, Philipp Nicol, Erion Xhepa, Michael Joner
AIMS: To quantify extra-valvular cardiac damage associated with severe aortic valve stenosis (AS), a novel staging model was proposed. This study aimed to validate this model in patients undergoing transcatheter aortic valve replacement (TAVR) as well as to assess its prognostic impact. METHODS AND RESULTS: Based on echocardiographic findings, the following stages were applied: isolated AS (stage 0), left ventricular (LV) damage (stage 1), left atrial or mitral valve damage (stage 2), pulmonary hypertension or tricuspid regurgitation (stage 3), or right ventricular dysfunction (stage 4)...
2022: Frontiers in Cardiovascular Medicine
#22
Rita Pavasini, Gioele Fabbri, Nicola Bianchi, Maria Angela Deserio, Federico Sanguettoli, Luca Zanarelli, Elisabetta Tonet, Giulia Passarini, Matteo Serenelli, Gianluca Campo
OBJECTIVES: In the last decade, percutaneous treatment of valve disease has changed the approach toward the treatment of aortic stenosis (AS) and mitral regurgitation (MR). The clinical usefulness of stress echocardiography (SE) in the candidates for transcatheter aortic valve implantation (TAVI) and transcatheter edge-to-edge repair (TEER) of MR remains to be established. Therefore, the key aim of this review is to assess the main applications of SE in patients undergoing TAVI or TEER...
2022: Frontiers in Cardiovascular Medicine
#23
JOURNAL ARTICLE
Amer Abdulla, Hani Jneid
No abstract text is available yet for this article.
November 2022: Catheterization and Cardiovascular Interventions
#24
JOURNAL ARTICLE
Alberto Pozzoli, Tiziano Torre, Giovanni Pedrazzini, Stefanos Demertzis, Enrico Ferrari
BACKGROUND: Mitral annular calcification (MAC) may represent a significant challenge for heart surgeons with an extremely high perioperative risk during mitral valve (MV) surgery. The risk is further increased when patients fail to be eligible for any percutaneous treatment, particularly because circumferential calcifications involving the anterior leaflet suggest a critical obstruction of the left ventricular outflow tract (LVOT). OBJECTIVES: The objective of this study was to evaluate residual mitral regurgitation (MR) after surgical mitral valve replacement using a Sapien 3 Ultra (Edwards Lifesciences, CA, USA) transcatheter aortic valve implantation (TAVI) prosthesis, reinforced with a pericardial skirt, in high-risk selected patients with severe MAC...
2022: Frontiers in Cardiovascular Medicine
#25
JOURNAL ARTICLE
Brunilda Alushi, Stephan Ensminger, Eva Herrmann, Ümniye Balaban, Timm Bauer, Andreas Beckmann, Sabine Bleiziffer, Helge Möllmann, Thomas Walther, Raffi Bekeredjian, Christian Hamm, Friedhelm Beyersdorf, Stephan Baldus, Andreas Boening, Volkmar Falk, Holger Thiele, Christian Frerker, Alexander Lauten
BACKGROUND: Patients with severe aortic stenosis (AS) frequently presented mitral regurgitation (MR), which may interfere with the standard echocardiographic measurements of mean pressure gradient (MPG), flow velocity, and aortic valve area (AVA). AIMS: Herein we investigated the prevalence and severity of MR in patients with severe AS and its role on the accuracy of the standard echocardiographic parameters of AS quantification. METHODS: Of all patients with severe AS undergoing transcatheter or surgical aortic valve replacement enrolled in the German Aortic Registry from 2011 to 2017, 119,641 were included in this study...
August 19, 2022: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#26
REVIEW
Xiling Zhang, Thomas Puehler, Derk Frank, Janarthanan Sathananthan, Stephanie Sellers, David Meier, Marcus Both, Philipp Blanke, Hatim Seoudy, Mohammed Saad, Oliver J Müller, Lars Sondergaard, Georg Lutter
In spite of the noninferiority of transcatheter aortic valve replacement (TAVR) in high- and intermediate-risk patients, there are still obstacles that need to be overcome before the procedure is further expanded and clinically integrated. The lack of evidence on the long-term durability of the bioprostheses used for TAVR remains of particular concern. In addition, surgery may be preferred over TAVR in patients with bicuspid aortic valve (BAV) or with concomitant pathologies such as other valve diseases (mitral regurgitation/tricuspid regurgitation), aortopathy, and coronary artery disease...
July 12, 2022: Journal of Cardiovascular Development and Disease
#27
JOURNAL ARTICLE
Aamir H Twing, Sanket Gokhale, Brody Slostad, Jonathan Meyer, Erik Simon, Helena Dickens, Stephanie D Kaluzna, Vicki Groo, Mayank Kansal, Adhir Shroff, Elliott M Groves
A subset of patients with severe aortic stenosis (AS) who are who underwent transcatheter aortic valve implantation (TAVI) also has mitral regurgitation (MR). Clinical outcomes in these patients with combined MR and AS have varied. The purpose of this study was to assess clinical outcomes and echocardiographic outcomes after TAVI in patients with preprocedural MR. A retrospective chart review from March 2018 to June 2020 identified all TAVI patients. Patients were assigned an MR class of mild, moderate, or severe based upon pre-TAVI transthoracic echocardiogram (TTE)...
August 15, 2022: American Journal of Cardiology
#28
JOURNAL ARTICLE
Elke Boxhammer, Moritz Mirna, Laura Bäz, Brunilda Alushi, Marcus Franz, Daniel Kretzschmar, Uta C Hoppe, Alexander Lauten, Michael Lichtenauer
BACKGROUND: Pulmonary capillary wedge pressure (PCWP) and left ventricular end-diastolic pressure (LVEDP) are often used as equivalents for determination of pulmonary hypertension (PH). PH is a comorbidity in patients with severe aortic valve stenosis (AS) and associated with limited prognosis. The aim of the study was to examine the role of differentiated classification basis of PCWP and LVEDP in patients planning for transcatheter aortic valve implantation (TAVI). METHODS: 284 patients with severe AS completed a combined left (LHC) and right heart catheterization (RHC) as part of a TAVI planning procedure...
May 25, 2022: Journal of Clinical Medicine
#29
REVIEW
Horațiu Moldovan, Bogdan-Ştefan Popescu, Elena Nechifor, Aida Badea, Irina Ciomaga, Claudia Nica, Ondin Zaharia, Daniela Gheorghiță, Marian Broască, Camelia Diaconu, Cătălina Parasca, Ovidiu Chioncel, Vlad Anton Iliescu
Pre-procedure mitral regurgitation (MR) is a frequent coexistent finding in patients undergoing transcatheter aortic valve replacement (TAVR), and most of them (up to 55%) experience a significant improvement in MR after the procedure. Although seldom described, mitral valve perforation after TAVR is a potentially serious complication that physicians should be aware of, as moderate or severe MR in TAVR recipients is associated with a high early mortality rate. We herein describe the case of a 65-year-old man presenting with worsening heart failure symptoms 5 months after TAVR due to an intraprocedural anterior mitral leaflet perforation and discuss the diagnostic process and therapeutic course of the case...
March 23, 2022: Medicina
#30
MULTICENTER STUDY
Vassili Panagides, David Del Val, Mohamed Abdel-Wahab, Norman Mangner, Eric Durand, Nikolaj Ihlemann, Marina Urena, Costanza Pellegrini, Francesco Giannini, Piotr Scislo, Zenon Huczek, Martin Landt, Vincent Auffret, Jan Malte Sinning, Asim N Cheema, Luis Nombela-Franco, Chekrallah Chamandi, Francisco Campelo-Parada, Erika Munoz-Garcia, Howard C Herrmann, Luca Testa, Won-Keun Kim, Juan Carlos Castillo, Alberto Alperi, Didier Tchetche, Antonio L Bartorelli, Samir Kapadia, Stefan Stortecky, Ignacio Amat-Santos, Harindra C Wijeysundera, John Lisko, Enrique Gutiérrez-Ibanes, Vicenç Serra, Luisa Salido, Abdullah Alkhodair, Ugolino Livi, Tarun Chakravarty, Stamatios Lerakis, Victoria Vilalta, Ander Regueiro, Rafael Romaguera, Utz Kappert, Marco Barbanti, Jean-Bernard Masson, Frédéric Maes, Claudia Fiorina, Antonio Miceli, Susheel Kodali, Henrique B Ribeiro, Jose Armando Mangione, Fabio Sandoli de Brito, Guglielmo Mario Actis Dato, Francesco Rosato, Maria-Cristina Ferreira, Valter Correia de Lima, Alexandre Siciliano Colafranceschi, Alexandre Abizaid, Marcos Antonio Marino, Vinicius Esteves, Julio Andrea, Roger R Godinho, Fernando Alfonso, Helene Eltchaninoff, Lars Søndergaard, Dominique Himbert, Oliver Husser, Azeem Latib, Hervé Le Breton, Clement Servoz, Isaac Pascual, Saif Siddiqui, Paolo Olivares, Rosana Hernandez-Antolin, John G Webb, Sandro Sponga, Raj Makkar, Annapoorna S Kini, Marouane Boukhris, Philippe Gervais, Axel Linke, Lisa Crusius, David Holzhey, Josep Rodés-Cabau
Scarce data exist on mitral valve (MV) infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI). This multicenter study included a total of 579 patients with a diagnosis of definite IE after TAVI from the IE after TAVI International Registry and aimed to evaluate the incidence, characteristics, management, and outcomes of MV-IE after TAVI. A total of 86 patients (14.9%) had MV-IE. These patients were compared with 284 patients (49.1%) with involvement of the transcatheter heart valve (THV) only...
June 1, 2022: American Journal of Cardiology
#31
JOURNAL ARTICLE
Han Zhang, Jin-Jie Xie, Rong-Juan Li, Yue-Li Wang, Bao-Rong Niu, Li Song, Jing Li, Ya Yang
BACKGROUND: Although transcatheter aortic valve implantation (TAVI) is a safe and effective treatment for aortic stenosis, it still carries some risks, such as valve leaks, stroke, and even death. The left ventricular global longitudinal strain (LVGLS) measurement may be useful for the prediction of adverse events during this operation. AIM: To explore the change of LVGLS during TAVI procedure and the relationship between LVGLS and perioperative adverse events. METHODS: In this study, 61 patients who had undergone percutaneous transfemoral TAVI were evaluated by transthoracic echocardiography...
February 26, 2022: World Journal of Clinical Cases
#32
REVIEW
Kush P Patel, Thomas A Treibel, Paul R Scully, Michael Fertleman, Samuel Searle, Daniel Davis, James C Moon, Michael J Mullen
Although transcatheter aortic valve implantation (TAVI) has revolutionised the landscape of treatment for aortic stenosis, there exists a cohort of patients where TAVI is deemed futile. Among the pivotal high-risk trials, one-third to half of patients either died or received no symptomatic benefit from the procedure at 1 year. Futility of TAVI results in the unnecessary exposure of risk for patients and inefficient resource utilisation for healthcare services. Several cardiac and extra-cardiac conditions and frailty increase the risk of mortality despite TAVI...
January 2022: Interventional Cardiology
#33
JOURNAL ARTICLE
Didrik Kjønås, Henrik Schirmer, Svend Aakhus, Jo Eidet, Siri Malm, Lars Aaberge, Rolf Busund, Assami Rösner
Background: Transcatheter aortic valve implantation (TAVI) has become a standard treatment option for patients with symptomatic aortic stenosis. Elderly high-risk patients treated with TAVI have a high residual mortality due to preexisting comorbidities. Knowledge of factors predicting futility after TAVI is sparse and clinical tools to aid the preoperative evaluation are lacking. The aim of this study was to evaluate if echocardiographic measures, including speckle-tracking analysis, in addition to clinical parameters, could aid in the prediction of mortality beyond 30 days after TAVI...
2021: Frontiers in Cardiovascular Medicine
#34
JOURNAL ARTICLE
Takeyuki Sajima, Taichi Onimaru, Shigehito Sawamura
BACKGROUND: Mitral regurgitation after transcatheter aortic valve implantation (TAVI) can be caused by various etiologies. CASE PRESENTATION: An 81-year-old woman with mild mitral regurgitation and complete right bundle branch block was scheduled to undergo TAVI under general anesthesia. After the deployment of the prosthetic valve, electrocardiography depicted a wide QRS wave and bradycardia, suggestive of complete atrioventricular block. Although there was no lesion indicative of tissue injury to the valve itself, worsening of mitral regurgitation was identified on transesophageal echocardiography...
December 18, 2021: JA Clinical Reports
#35
MULTICENTER STUDY
Nobuhiro Yoshijima, Tetsuya Saito, Taku Inohara, Atsushi Anzai, Hikaru Tsuruta, Hideyuki Shimizu, Keiichi Fukuda, Toru Naganuma, Kazuki Mizutani, Masahiro Yamawaki, Norio Tada, Futoshi Yamanaka, Shinichi Shirai, Minoru Tabata, Hiroshi Ueno, Kensuke Takagi, Yusuke Watanabe, Masanori Yamamoto, Kentaro Hayashida
OBJECTIVE: Transcatheter aortic valve replacement (TAVR) improves clinical symptoms in most patients with severe aortic stenosis (AS). However, some patients do not benefit from the symptom-reducing effects of TAVR. We assessed the predictors and clinical outcomes of poor symptomatic improvement (SI) after TAVR. METHODS: A total of 1749 patients with severe symptomatic AS undergoing transfemoral TAVR were evaluated using the Japanese multicentre TAVR registry. Poor SI was defined as readmission for heart failure (HF) within 1 year after TAVR or New York Heart Association (NYHA) class ≥3 after 1 year...
November 2021: Open Heart
#36
JOURNAL ARTICLE
Clarence Pingpoh, Duchelle Donfack, Tim Berger, Maximillian Kreibich, Friedhelm Beyersdorf, Paul Puiu, Holger Schroefel, Willibald Hochholzer, Martin Czerny, Matthias Siepe
OBJECTIVE: Mitral regurgitation (MR) and severe aortic valve stenosis often coexist. Concomitant replacement of both valves is associated with a significantly higher morbidity and mortality. This study sought to investigate the progression of MR after isolated aortic valve replacement. METHODS: We analyzed the severity and progression of MR, survival and echocardiographic parameters in 506 patients with severe aortic valve stenosis and moderate to severe functional MR who received isolated aortic valve replacement during a 9-year period...
November 22, 2021: Thoracic and Cardiovascular Surgeon
#37
JOURNAL ARTICLE
Juqian Zhang, Arnaud Bisson, Jad Boumhidi, Julien Herbert, Christophe Saint Etienne, Anne Bernard, Gregory Y H Lip, Laurent Fauchier
Mitral regurgitation (MR) is the most common valvular lesion in transcatheter aortic valve implantation (TAVI) recipients. This study aims to assess the long-term prognostic impact of baseline MR in TAVI patients. METHODS: Adult patients who underwent TAVI were identified in the French National Hospital Discharge Database. All-cause and cardiovascular mortality, stroke, and rehospitalization with heart failure (HF) were compared in TAVI patients with and without baseline MR and tricuspid regurgitation (TR), respectively; the associations of MR and TR with the outcomes were assessed by Cox regression...
September 2, 2021: Journal of Clinical Medicine
#38
JOURNAL ARTICLE
Eijiro Nogami, Junji Yunoki, Yuki Takeuchi, Yuichi Koga, Sojiro Amamoto, Baku Takahashi, Motonori Uchino, Shuichiro Yoshitake, Manabu Itoh, Shugo Koga, Atsuhisa Tanaka, Keiji Kamohara
The patient was an 81-year-old man. Transcatheter aortic valve implantation( TAVI) was performed for severe aortic stenosis using Evolut R. The patient moved to intensive care unit without an adverse event after the operation. But repeated acute heart failure occurred several times during hospital stay. Mitral regurgitation (MR) was worsened from mild at baseline to moderate or more by transthoracic echocardiography. Various factors that worsened MR after TAVI have been reported, and treatment strategy for severe aortic stenosis patients with MR should be carefully developed...
September 2021: Kyobu Geka. the Japanese Journal of Thoracic Surgery
#39
REVIEW
Tomasz Tokarek, Artur Dziewierz, Dariusz Dudek
There is a worldwide expansion in percutaneous therapy for valvular heart disease. Rapidly evolving technology and the general increase in life expectancy will support the evolution of new treatment options dedicated to structural heart interventions. Transcatheter aortic valve implantation for severe aortic valve stenosis and percutaneous mitral valve repair with the MitraClip system for severe mitral regurgitation have been demonstrated as a feasible, innovative alternative for surgical treatment. Despite the inequality in clinical experience, both procedures have encouraging results and now are a part of everyday clinical practice...
June 2021: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
#40
REVIEW
Gabriela Tirado-Conte, Angela McInerney, Pilar Jimenez-Quevedo, Manuel Carnero, Luis A Marroquin Donday, Alberto De Agustin, Guy Witberg, Eduardo Pozo, Fabian Islas, Pedro Marcos-Alberca, Javier Cobiella, Ran Koronowski, Carlos Macaya, Josep Rodes-Cabau, Luis Nombela-Franco
INTRODUCTION: Significant mitral regurgitation (MR) frequently coexists in patients with severe symptomatic aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). These patients have worse clinical outcomes than those with non-significant MR, especially if MR persists after treatment of the aortic stenosis. The optimal treatment approach for this challenging high-risk population is not well defined. AREAS COVERED: This review aims to present the current literature on concomitant significant MR in the TAVR population, and to provide a comprehensive algorithmic approach for clinical decision-making in this challenging cohort of patients...
August 2021: Expert Review of Cardiovascular Therapy
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