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Cholangio carcinoma

Aiman Obed, Abdalla Bashir, Anwar Jarrad
BACKGROUND: Obesity presents one of the leading causes of many chronic liver disorders and injuries. Nowadays, non-alcoholic steatohepatitis (NASH) demonstrates a challenging issue for the global health system. NASH can progress to life-threatening conditions such as cirrhosis and hepatocellular or cholangio carcinoma. Currently, NASH cirrhosis is a major indication for liver transplant (LT). CASE PRESENTATION: We present the case of a 37 year-old male who has lost 74 kg after undergoing successful laparoscopic sleeve gastrectomy (SG) four years ago...
May 29, 2018: BMC Surgery
F Oldhafer, K I Ringe, K Timrott, M Kleine, O Beetz, W Ramackers, S Cammann, J Klempnauer, F W R Vondran, H Bektas
PURPOSE: Treatment of malignancies invading the hepatic veins/inferior vena cava is a surgical challenge. An ante situm technique allows luxation of the liver in front of the situs to perform tumor resection. Usually, cold perfusion and veno-venous bypass are applied. Our experience with modified ante situm resection relying only on total vascular occlusion is reported. METHODS: Retrospective analysis on an almost 15-year experience with ante situm resection without application of cold perfusion or veno-venous bypass RESULTS: The ante situm technique was applied on eight patients...
February 22, 2018: Langenbeck's Archives of Surgery
Nicolas Meurisse, Jacques Pirenne, Diethard Monbaliu
INTRODUCTION: Non-anastomotic biliary strictures (NAS) represent a major cause of morbidity, graft loss, and mortality after liver transplantation (LTx). NAS can result from an ischemic/immune-mediated injury, or from the cytotoxic effect that bile salts have on the biliary mucosa under hypothermic conditions. For this reason it is crucial to flush the bile duct at the time of procurement. PRESENTATION OF CASE: We report a case of an imported liver with an accidentally ligated and subsequently completely unflushed common bile duct...
2017: International Journal of Surgery Case Reports
S Mohammed, M M Chowdhury, A A Ullah, S M Towhid, S A Sobhan, I J Zeba, M M Haque, M T Islam, M Hussain, T K Roy, S R Russel, A M Chowdhury, M K Alam
Acinar cell carcinoma (ACC) of the pancreas is a very rare neoplasm. We report a case of pancreatic acinar cell carcinoma involving the uncinate process of the pancreas. A 45 year old man presented with a painful upper abdominal mass without any jaundice or weight loss. Computed Tomography (CT) and Magnetic Resonance Cholangio-Pancreatography (MRCP) indicated a mass lesion in the uncinate process of the pancreas. He underwent Whipple's procedure (Pancreaticoduodenectomy). Histological slides revealed features of Acinar cell carcinoma (ACC) in the uncinate process of the pancreas and a lymph node...
July 2017: Mymensingh Medical Journal: MMJ
Yuko Ishibashi, Hiroshi Ohtsu, Masako Ikemura, Yasuko Kikuchi, Takayoshi Niwa, Kotoe Nishioka, Yoshihiro Uchida, Hirona Miura, Susumu Aikou, Toshiaki Gunji, Nobuyuki Matsuhashi, Yasukazu Ohmoto, Takeshi Sasaki, Yasuyuki Seto, Toshihisa Ogawa, Keiichiro Tada, Sachiyo Nomura
Breast cancer remains a common malignancy in women, but the take-up for breast cancer screening programs in Japan is still low, possibly due to its perceived inconvenience. TFF1 and TFF3 are expressed in both breast cancer tissue and normal breast. Serum trefoil proteins were reported as cancer screening markers for gastric, prostate, lung, pancreatic cancer and cholangio carcinoma. The purpose of this study was to examine whether serum trefoil proteins could be screening biomarkers for breast cancer. Serum trefoil proteins in 94 breast cancer patients and 84 health check females were measured by ELISA...
July 7, 2017: Scientific Reports
Peter Robert Galle
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide. HCC represents more than 90% of primary liver cancers. There is growing incidence of HCC worldwide. In the western world, HCC arises in a cirrhotic background in up to 90% of cases, and cirrhosis itself is a progressive disease that affects patient survival. Thus, outcome in patients with HCC and the chances for anti-tumor treatment and it is results are dependent not only on tumor-associated factors but also on the liver function...
2017: Digestive Diseases
John K L Wong, Desmond Campbell, Ngoc Diem Ngo, Fanny Yeung, Guo Cheng, Clara S M Tang, Patrick H Y Chung, Ngoc Son Tran, Man-Ting So, Stacey S Cherny, Pak C Sham, Paul K Tam, Maria-Mercè Garcia-Barcelo
BACKGROUND: Congenital dilatation of the bile-duct (CDD) is a rare, mostly sporadic, disorder that results in bile retention with severe associated complications. CDD affects mainly Asians. To our knowledge, no genetic study has ever been conducted. METHODS: We aim to identify genetic risk factors by a "trio-based" exome-sequencing approach, whereby 31 CDD probands and their unaffected parents were exome-sequenced. Seven-hundred controls from the local population were used to detect gene-sets significantly enriched with rare variants in CDD patients...
December 12, 2016: BMC Medical Genomics
M Benavides, A Antón, J Gallego, M A Gómez, A Jiménez-Gordo, A La Casta, B Laquente, T Macarulla, J R Rodríguez-Mowbray, J Maurel
Biliary tract cancer (BTC) is an uncommon and highly fatal malignancy. It is composed of three main different entities; Gall bladder carcinoma (GBC), intrahepatic cholangiocarcinoma (iCC) and extrahepatic cholangiocarcinoma (eCC) sharing different genetic, risk factors and clinical presentation. Multidetector-row computed tomography (MDCT) and magnetic resonance cholangio-pancreatography (MRCP) are the more important diagnostic techniques. Surgery is the only potentially curative therapy but disease recurrence is frequent...
December 2015: Clinical & Translational Oncology
Tashi Dendup, James M Richter, Yoshio Yamaoka, Kinley Wangchuk, Hoda M Malaty
AIM: To estimate the prevalence of gastric cancer (GC) in a cohort of patients diagnosed with GC and to compare it with patients diagnosed with all other types of gastro-intestinal (GI) cancer during the same period. METHODS: Between 2008 and 2013, five-year period, the medical records of all GI cancer patients who underwent medical care and confirm diagnosis of cancer were reviewed at the National Referral Hospital, Thimphu which is the only hospital in the country where surgical and cancer diagnosis can be made...
October 14, 2015: World Journal of Gastroenterology: WJG
Belqees Yawar, Sadia Babar, Imaad-Ur-Rehman, Farah Sana, Faiza Javed, Mohammad Yousuf Chaudhary
OBJECTIVE: To determine the patterns of peritoneal involvement in patients with abdominopelvic malignancies. STUDY DESIGN: Retrospective observational study. PLACE AND DURATION OF STUDY: Shifa International Hospital, Islamabad, Pakistan, from May 2004 to May 2012. METHODOLOGY: Two hundred and three patients with histopathologically proven abdominopelvic malignancies with peritoneal involvement who underwent contrast-enhanced CT abdomen and pelvis were identified through electronic data base system and were included in this study after ethical committee approval...
June 2015: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Takehiro Noji, Takahiro Tsuchikawa, Tomoko Mizota, Keisuke Okamura, Toru Nakamura, Eiji Tamoto, Toshiaki Shichinohe, Satoshi Hirano
BACKGROUND: Various chemotherapies have been used as best practice to treat recurrent biliary malignancies. Conversely, relatively few surgeries have been described for recurrent extrahepatic biliary carcinoma (RExBC), so whether surgery for RExBC is feasible has remained unclear. This retrospective study was conducted to evaluate the feasibility of surgery for RExBC. METHODS: From February 2000 to January 2014, a total of 27 patients, comprising 18 patients with extrahepatic cholangiocarcinoma and 9 patients with gallbladder carcinoma, met our criteria for radical resection of RExBC (resection group)...
2015: World Journal of Surgical Oncology
Johan Burisch, Pia Munkholm
BACKGROUND AND AIMS: The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), are chronic relapsing disorders of unknown aetiology. The aim of this review is to present the latest epidemiology data on occurrence, disease course, risk for surgery, as well as mortality and cancer risks. MATERIAL AND METHODS: Gold standard epidemiology data on the disease course and prognosis of patients with inflammatory bowel disease (IBD) are based on unselected population-based cohort studies...
August 2015: Scandinavian Journal of Gastroenterology
Ayman El Nakeeb, Ahmad M Sultan, Emad Hamdy, Ehab El Hanafy, Ehab Atef, Tarek Salah, Ahmed A El Geidie, Tharwat Kandil, Mohamed El Shobari, Gamal El Ebidy
AIM: To evaluate the efficacy of intraoperative endoscopic retrograde cholangio-pancreatography (ERCP) combined with laparoscopic cholecystectomy (LC) for patients with gall bladder stones (GS) and common bile duct stones (CBDS). METHODS: Patients treated for GS with CBDS were included. LC and intraoperative transcystic cholangiogram (TCC) were performed in most of the cases. Intraoperative ERCP was done for cases with proven CBDS. RESULTS: Eighty patients who had GS with CBDS were included...
January 14, 2015: World Journal of Gastroenterology: WJG
Hauke S Heinzow, Sara Kammerer, Carina Rammes, Johannes Wessling, Dirk Domagk, Tobias Meister
AIM: To compare endoscopic retrograde cholangio-pancreatography (ERCP), intraductal ultrasound (IDUS), endosonography (EUS), endoscopic transpapillary forceps biopsies (ETP) and computed tomography (CT) with respect to diagnosing malignant bile duct strictures. METHODS: A patient cohort with bile duct strictures of unknown etiology was examined by ERCP and IDUS, ETP, EUS, and CT. The sensitivity, specificity, and accuracy rates of the diagnostic procedures were calculated based on the definite diagnoses proved by histopathology or long-term follow-up in those patients who did not undergo surgery...
August 14, 2014: World Journal of Gastroenterology: WJG
Min-Su Park, Sang-Mok Lee
(18)F-Fluorodeoxyglucose positron-emission with computed tomography ((18)F-FDG PET-CT) is an imaging technique based on the increased uptake of glucose characteristically seen in malignant lesions. The preoperative maximum standardized uptake value (SUVmax) of PET-CT has been identified as a powerful significant prognostic factor for predicting recurrence in malignant tumors. Therefore, the aim of this study was to determine whether (18)F-FDG PET-CT has a prognostic significance in patients with biliary tract cancer after surgical resection...
May 2014: Anticancer Research
J Rosendahl, J Mössner
The diagnosis of cystic pancreatic lesions is raised more often within the last years. This is due to the fact that diagnostic opportunities and modalities such as endosonography (EUS), magnetic resonance imaging (MRI), magnetic resonance cholangio-pancreatography (MRCP), and computertomography (CT) have both improved and are more widely used. As such new recommendations were needed, since the knowledge on cystic pancreatic lesions has increased after the last consensus statement published in 2006.  In this review the main aspects of the recent consensus statements for diagnosis and therapy or in some cases the surveillance strategy of intraductal papillary mucinous neoplasm will be summarized...
May 2014: Deutsche Medizinische Wochenschrift
S Karki, K S Joshi, S Regmi, R B Gurung, B Malla
BACKGROUND: The diagnosis of obstructive jaundice relies on proper history taking, clinical examination, laboratory investigations and different non invasive imaging modalities like Ultrasonography (USG), Cholangio Computed Tomography (CCT), Magnetic resonance Imaging (MRI) with Magnetic Resonance Cholangio Pancreatography (MRCP) and invasive modalities like endoscopic retrograde cholangiography (ERCP) and percutaneous trans hepatic cholangiography (PTC). OBJECTIVE: To compare the role of ultrasound with endoscopic retrograde cholangiography and to determine the major causes of obstructive jaundice in our prospect...
July 2013: Kathmandu University Medical Journal (KUMJ)
Mayumi Kondo, Eiko Okamoto, Kentaro Takagi, Atsushi Tamura, Takao Shibayama, Ryota Seki, Jun Takasaki, Hidetoshi Amagasa, Hirotaka Kamikozuru, Hideaki Ganno, Katsunori Ami, Akira Fukuda, Takeshi Nagahama, Masayuki Ando, Kuniyoshi Arai
The patient was an 87-year-old woman who was diagnosed with atrial fibrillation, which was treated with an anticoagulant, and with chronic kidney disease. The patient was diagnosed as having liver dysfunction and lower cholangiocellular carcinoma (cStage I) on ultrasonography and magnetic resonance cholangiopancreatography. Since it was impossible to perform curative resection owing to the patient's decreased cardiac and renal function, we performed palliative endoscopic retrograde biliary drainage (ERBD) with a plastic stent (PS), and the patient was discharged 11 days later...
November 2013: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Eduardo Gálvez, Gustavo Gálvez, Aurelio Barboza, Eduardo Barboza, Juan Manuel Combe, Mario R Combe, Juan Combe, Javier Arias Stella C, Javier Arias Stella
Ohashi described for the first time the IPMN on 1982 as a pancreatic neoplasia with mucine cells forming papillae and producing dilatation of the main pancreatic duct or its branches. The IPMN represent the 1% of the pancreatic tumors and 5% of the cystic neoplasias. It is potentially malignant in a period of five years being more frequent in males between 60-70 and clinically these patients' presents as acute, recurrent or chronic pancreatitis, with an incidence of malignancy from 25% to 70%. CT scan and cholangio MRI allows the diagnosis, the variety, localization and possibility of determine malignancy...
January 2013: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
Tobias Meister, Hauke S Heinzow, Carina Woestmeyer, Philipp Lenz, Josef Menzel, Torsten Kucharzik, Wolfram Domschke, Dirk Domagk
AIM: To report the largest patient cohort study investigating the diagnostic yield of intraductal ultrasound (IDUS) in indeterminate strictures of the common bile duct. METHODS: A patient cohort with bile duct strictures of unknown etiology was examined by IDUS. Sensitivity, specificity and accuracy rates of IDUS were calculated relating to the definite diagnoses proved by histopathology or long-term follow-up in those patients who did not undergo surgery. Analysis of the endosonographic report allowed drawing conclusions with respect to the T and N staging in 147 patients...
February 14, 2013: World Journal of Gastroenterology: WJG
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