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https://www.readbyqxmd.com/read/29344358/the-global-problem-of-childhood-diarrhoeal-diseases-emerging-strategies-in-prevention-and-management
#1
REVIEW
Margaret Mokomane, Ishmael Kasvosve, Emilia de Melo, Jeffrey M Pernica, David M Goldfarb
Acute diarrhoeal diseases remain a leading cause of global morbidity and mortality particularly among young children in resource-limited countries. Recent large studies utilizing case-control design, prospective sampling and more sensitive and broad diagnostic techniques have shed light on particular pathogens of importance and highlighted the previously under recognized impact of these infections on post-acute illness mortality and growth. Vaccination, particularly against rotavirus, has emerged as a key effective means of preventing significant morbidity and mortality from childhood diarrhoeal disease...
January 2018: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/29344009/evaluation-of-nipple-aspirate-fluid-as-a-diagnostic-tool-for-early-detection-of-breast-cancer
#2
REVIEW
Sadr-Ul Shaheed, Catherine Tait, Kyriacos Kyriacou, Richard Linforth, Mohamed Salhab, Chris Sutton
There has been tremendous progress in detection of breast cancer in postmenopausal women, resulting in two-thirds of women surviving more than 20 years after treatment. However, breast cancer remains the leading cause of cancer-related deaths in premenopausal women. Breast cancer is increasing in younger women due to changes in life-style as well as those at high risk as carriers of mutations in high-penetrance genes. Premenopausal women with breast cancer are more likely to be diagnosed with aggressive tumours and therefore have a lower survival rate...
2018: Clinical Proteomics
https://www.readbyqxmd.com/read/29340212/40-years-without-smallpox
#3
G A Shchelkunova, S N Shchelkunov
The last case of natural smallpox was recorded in October, 1977. It took humanity almost 20 years to achieve that feat after the World Health Organization had approved the global smallpox eradication program. Vaccination against smallpox was abolished, and, during the past 40 years, the human population has managed to lose immunity not only to smallpox, but to other zoonotic orthopoxvirus infections as well. As a result, multiple outbreaks of orthopoxvirus infections in humans in several continents have been reported over the past decades...
October 2017: Acta Naturae
https://www.readbyqxmd.com/read/29339224/emerging-souvenirs-clinical-presentation-of-the-returning-traveller-with-imported-arbovirus-infections-in-europe
#4
Isabella Eckerle, Violeta Briciu, Onder Ergonul, Mihaela Lupse, Anna Papa, Amanda Radulescu, Sotirios Tsiodras, Christine Tsitou, Christian Drosten, Véronique Nussenblatt, Chantal Reusken, Louise Sigfrid, Nick J Beeching
BACKGROUND: Arboviruses are an emerging group of viruses that are causing increasing health concerns globally, including in Europe. Clinical presentation usually consists of a non-specific febrile illness that may be accompanied by rash, arthralgia and arthritis and/or with neurological or haemorrhagic syndromes. The range of differential diagnoses of other infectious and non-infectious aetiologies is broad, presenting a challenge for physicians. While knowledge of the geographic distribution of pathogens and the current epidemiological situation, incubation periods, exposure risk factors and vaccination history can help guide the diagnostic approach, the non-specific and variable clinical presentation can delay final diagnosis...
January 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29336569/paper-based-dna-reader-for-visualized-quantification-of-soil-transmitted-helminth-infections
#5
Alex Guan Wang, Tianyu Dong, Hayam Mansour, Gabriela Matamoros, Ana L Sanchez, Feng Li
Soil-transmitted helminth (STH) infections are a global health issue affecting nearly one-third of the world's population. As most endemic areas of STH are impoverished countries or regions with limited healthcare resources, the accurate diagnosis of STH requires analytical tools that are not only quantitative, but also portable, inexpensive, and with no or minimal demand for external instrument. Herein, we introduce a novel paper-based diagnostic device, termed quantitative paper-based DNA reader (qPDR), capable of quantifying STH at the molecular level by measuring distance as readout, thus eliminating the need for external readers...
January 16, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29331743/preliminary-investigation-of-human-exhaled-breath-for-tuberculosis-diagnosis-by-multidimensional-gas-chromatography-time-of-flight-mass-spectrometry-and-machine-learning
#6
Marco Beccaria, Theodore R Mellors, Jacky S Petion, Christiaan A Rees, Mavra Nasir, Hannah K Systrom, Jean W Sairistil, Marc-Antoine Jean-Juste, Vanessa Rivera, Kerline Lavoile, Patrice Severe, Jean W Pape, Peter F Wright, Jane E Hill
Tuberculosis (TB) remains a global public health malady that claims almost 1.8 million lives annually. Diagnosis of TB represents perhaps one of the most challenging aspects of tuberculosis control. Gold standards for diagnosis of active TB (culture and nucleic acid amplification) are sputum-dependent, however, in up to a third of TB cases, an adequate biological sputum sample is not readily available. The analysis of exhaled breath, as an alternative to sputum-dependent tests, has the potential to provide a simple, fast, and non-invasive, and ready-available diagnostic service that could positively change TB detection...
January 4, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29329054/relationship-between-sedentary-behavior-and-depression-a-mediation-analysis-of-influential-factors-across-the-lifespan-among-42-469-people-in-low-and-middle-income-countries
#7
Brendon Stubbs, Davy Vancampfort, Joseph Firth, Felipe B Schuch, Mats Hallgren, Lee Smith, Benjamin Gardner, Kai G Kahl, Nicola Veronese, Marco Solmi, André F Carvalho, Ai Koyanagi
BACKGROUND: Sedentary behavior (SB) is associated with diabetes, cardiovascular disease and low mood. There is a paucity of multi-national research investigating SB and depression, particularly among low- and middle-income countries. This study investigated the association between SB and depression, and factors which influence this. METHODS: Cross-sectional data were analyzed from the World Health Organization's Study on Global Ageing and Adult Health. Depression was based on the Composite International Diagnostic Interview...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29324858/mapping-the-geographical-distribution-of-podoconiosis-in-cameroon-using-parasitological-serological-and-clinical-evidence-to-exclude-other-causes-of-lymphedema
#8
Kebede Deribe, Amuam Andrew Beng, Jorge Cano, Abdel Jelil Njouendo, Jerome Fru-Cho, Abong Raphael Awah, Mathias Esum Eyong, Patrick W Chounna Ndongmo, Emanuele Giorgi, David M Pigott, Nick Golding, Rachel L Pullan, Abdisalan M Noor, Fikre Enquselassie, Christopher J L Murray, Simon J Brooker, Simon I Hay, Peter Enyong, Melanie J Newport, Samuel Wanji, Gail Davey
BACKGROUND: Podoconiosis is a non-filarial elephantiasis, which causes massive swelling of the lower legs. It was identified as a neglected tropical disease by WHO in 2011. Understanding of the geographical distribution of the disease is incomplete. As part of a global mapping of podoconiosis, this study was conducted in Cameroon to map the distribution of the disease. This mapping work will help to generate data on the geographical distribution of podoconiosis in Cameroon and contribute to the global atlas of podoconiosis...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29323478/simultaneous-detection-of-antibiotic-resistance-genes-on-paper-based-chip-using-ru-phen-2dppz-2-turn-on-fluorescence-probe
#9
Bofan Li, Xiaoming Zhou, Hongxing Liu, Huaping Deng, Ru Huang, Da Xing
Antibiotic resistance, the ability of some bacteria to resist antibiotic drug, has been a major global health burden due to the extensive use of antibiotic agents. Antibiotic resistance is encoded via respective genes, hence the specific detection of these genes is necessary for diagnostic and treat of antibiotic resistance cases. Conventional methods for monitoring antibiotic resistance genes require sample to be transported to a central laboratory for tedious and sophisticated tests, which is grueling and time-consuming...
January 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29320495/the-who-2016-verbal-autopsy-instrument-an-international-standard-suitable-for-automated-analysis-by-interva-insilicova-and-tariff-2-0
#10
Erin K Nichols, Peter Byass, Daniel Chandramohan, Samuel J Clark, Abraham D Flaxman, Robert Jakob, Jordana Leitao, Nicolas Maire, Chalapati Rao, Ian Riley, Philip W Setel
BACKGROUND: Verbal autopsy (VA) is a practical method for determining probable causes of death at the population level in places where systems for medical certification of cause of death are weak. VA methods suitable for use in routine settings, such as civil registration and vital statistics (CRVS) systems, have developed rapidly in the last decade. These developments have been part of a growing global momentum to strengthen CRVS systems in low-income countries. With this momentum have come pressure for continued research and development of VA methods and the need for a single standard VA instrument on which multiple automated diagnostic methods can be developed...
January 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29316927/global-sequence-diversity-of-the-lactate-dehydrogenase-gene-in-plasmodium-falciparum
#11
Phumin Simpalipan, Sittiporn Pattaradilokrat, Pongchai Harnyuttanakorn
BACKGROUND: Antigen-detecting rapid diagnostic tests (RDTs) have been recommended by the World Health Organization for use in remote areas to improve malaria case management. Lactate dehydrogenase (LDH) of Plasmodium falciparum is one of the main parasite antigens employed by various commercial RDTs. It has been hypothesized that the poor detection of LDH-based RDTs is attributed in part to the sequence diversity of the gene. To test this, the present study aimed to investigate the genetic diversity of the P...
January 9, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29315488/towards-an-international-language-for-incontinence-associated-dermatitis-iad-design-and-evaluation-of-psychometric-properties-of-the-ghent-global-iad-categorisation-tool-globiad-in-30-countries
#12
D Beeckman, K Van den Bussche, P Alves, M C Arnold Long, H Beele, G Ciprandi, F Coyer, T de Groot, D De Meyer, E Deschepper, A M Dunk, A Fourie, P García-Molina, M Gray, A Iblasi, R Jelnes, E Johansen, A Karadağ, K Leblanc, Z Kis Dadara, S Meaume, A Pokorna, M Romanelli, S Ruppert, L Schoonhoven, S Smet, C Smith, A Steininger, M Stockmayr, N Van Damme, D Voegeli, A Van Hecke, S Verhaeghe, K Woo, J Kottner
BACKGROUND: Incontinence-associated dermatitis (IAD) is a specific type of irritant contact dermatitis with different levels of severity. An internationally accepted instrument to assess the severity of IAD in adults with established diagnostic accuracy, agreement, and reliability is needed to support clinical practice and research. OBJECTIVES: To design and psychometrically evaluate the Ghent Global IAD Categorisation Tool (GLOBIAD). METHODS: The design was based on expert consultation using a three-round Delphi procedure with 34 experts from 13 countries...
January 8, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29306992/health-and-welfare-of-women-and-child-survival-a-key-to-nation-building
#13
Meharban Singh
Health of women has a profound effect on the health and welfare of communities, countries and the world at large. A large number of social, economic, educational, political and religious dimensions impact the lives of girls and women with repercussions on their health and status in society and welfare of their children. It is a sad reality that a large number of children, adolescents and women worldwide have limited or no access to essential health care services, nutrition and education. Gender inequity and discrimination against girls cannot be bridged unless there are equal opportunities for healthcare and education for boys and girls...
January 6, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29306954/management-of-functional-somatic-syndromes-and-bodily-distress
#14
Peter Henningsen, Stephan Zipfel, Heribert Sattel, Francis Creed
Functional somatic syndromes (FSS), like irritable bowel syndrome or fibromyalgia and other symptoms reflecting bodily distress, are common in practically all areas of medicine worldwide. Diagnostic and therapeutic approaches to these symptoms and syndromes vary substantially across and within medical specialties from biomedicine to psychiatry. Patients may become frustrated with the lack of effective treatment, doctors may experience these disorders as difficult to treat, and this type of health problem forms an important component of the global burden of disease...
January 6, 2018: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/29306921/building-a-high-quality-oncology-nursing-workforce-through-lifelong-learning-the-de-souza-model
#15
Mary Jane Esplen, Jiahui Wong, Esther Green, Joy Richards, Jane Li
AbstractCancer is one of the leading causes of death in the world. Along with increased new cases, cancer care has become increasingly complex due to advances in diagnostics and treatments, greater survival, and new models of palliative care. Nurses are a critical resource for cancer patients and their families. Their roles and responsibilities are expanding across the cancer care continuum, calling for specialized training and support. Formal education prepares nurses for entry level of practice, however, it does not provide the specialized competencies required for quality care of cancer patients...
January 5, 2018: International Journal of Nursing Education Scholarship
https://www.readbyqxmd.com/read/29304322/epidemiological-patterns-of-leukaemia-in-184-countries-a-population-based-study
#16
Adalberto Miranda-Filho, Marion Piñeros, Jacques Ferlay, Isabelle Soerjomataram, Alain Monnereau, Freddie Bray
BACKGROUND: Leukaemia is a heterogeneous group of haemopoietic cancers that comprises a number of diverse and biologically distinct subgroups. We examine the leukaemia burden worldwide and highlight the distinct incidence patterns in order to elucidate explanatory factors that may support preventive measures and health resource planning. We aimed to estimate the global burden of leukaemia incidence according to the four major subtypes stratified by age and sex. METHODS: In this population-based study, we assessed leukaemia incidence for the major subtypes using the Cancer Incidence in Five Continents Volume X (CI5-X), which includes data from 290 cancer registries in 68 countries covering the diagnostic period 2003-07, for all ages and both sexes...
January 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29302646/hospital-and-community-based-surveillance-of-zika-and-dengue-viruses-in-indonesia
#17
Nasronudin Suharto, Muhammad Amin, Diah Puspita Rini, Achmad Chusnu Romdhoni, Purwaningsih Zulfayandi Pawanis, Muhammad Syamsul Hidayat
Background: Zika virus remained silent for few decades after its first recognition in 1947. Recently, Zika drew global attention due to the outbreak in Pacific island and Latin Americas. The concern was escalating given the shared vector of Zika and dengue with possible deleterious complications. Surabaya as one of the largest cities in Indonesia with high mobility of people is endemic to dengue. This study was aimed to detect Zika infection during dengue outbreaks in Surabaya. Materials and Methods: This was a surveillance study involving patients visiting 4 public hospitals and 8 primary health care centres (PHCs)...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29302515/chasing-viruses-feverishly
#18
Chandrakant Lahariya
A number of viral diseases have emerged and re-emerged in India and globally, in the last few years. Effective prevention and control of these diseases require, in addition to a functioning disease surveillance system, interventions both before and after disease occurrence, and a combination of personal and population services. However, the current efforts to control emerging viral diseases in India has major therapeutic focus (and attention on diagnostic and curative services) and there is limited attention on preventive and promotive components...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29291476/neurodevelopmental-disorders-in-prison-inmates-comorbidity-and-combined-associations-with-psychiatric-symptoms-and-behavioural-disturbance
#19
Susan Young, Rafael A González, Hannah Mullens, Laura Mutch, Isabella Malet-Lambert, Gisli H Gudjonsson
The identification and management of inmates with neurodevelopmental disorders (ND) has been insufficiently addressed in the literature. We estimated the proportion of cases with Attention deficit/hyperactivity disorder (ADHD), Autism spectrum disorder (ASD) and Intellectual disability (ID) in prison, their comorbidity, and associations with disruptive behaviours and with psychiatric symptoms. Further, we examined the role of coexisting ND on psychiatric symptoms and attitudes toward violence. All 390 male inmates underwent an assessment that included the Diagnostic Interview for ADHD in Adults 2...
December 15, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29291207/history-and-current-trends-in-influenza-virus-infections-with-special-reference-to-sri-lanka
#20
REVIEW
R A M Rafeek, M V M Divarathna, F Noordeen
The World Health Organization (WHO) estimates that approximately one billion people are infected and up to 500,000 people die from influenza each year in the world. Influenza is considered to be the greatest killer of the human populations, due to the 1918 Spanish flu, which killed millions around the world. Despite the effective treatment available against influenza, it still contributes to significant morbidity and mortality. Currently circulating influenza strains in humans include influenza A (H1N1)pdm09, influenza A (H3N2) and influenza B viruses, (B/Victoria and B/Yamagata)...
September 2017: Virusdisease
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