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https://www.readbyqxmd.com/read/29778267/the-road-to-hepatitis-c-virus-cure-practical-considerations-from-a-health-system-s-perspective
#1
REVIEW
M Cabell Jonas, Bernadette Loftus, Michael A Horberg
Hepatitis C virus infection remains a significant global health problem. Many individuals are unaware of their infection or disease stage. Innovations in care that promote rapid and easy identification of at-risk populations for screening, comprehensive diagnostic screening, and triage to curative direct-acting antiviral medications will accelerate efforts to eradicate hepatitis C.
June 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29773779/prospects-for-us-cuba-cooperation-in-gastroenterology-hepatology-and-liver-transplantation
#2
Marlen I Castellanos-Fernández, Mirtha Infante-Velázquez, Enrique Arús-Soler, Marcelo Kugelmas, Ramón Bataller, Ramón Villamil-Martínez, Zaily Dorta-Guridi, Caridad Ruenes-Domenech
Gastroenterology, hepatology and liver transplant exchanges between the USA and Cuba have mainly consisted of scientific events and short visits. This has facilitated Cuba's inclusion in recognized scientific organizations, familiarity with Cuba's biotech products for treatment of liver disease, and access by Cuban professionals to the highest level of scientific information for clinical practice. It has also given health professionals in the US a more accurate picture of Cuba's health sector. The results of the Global Alcoholic Liver Disease Survey, which included Cuba and was designed and coordinated in the USA, opened doors to joint research and scientific publications...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29770056/hiv-in-canada-surveillance-report-2016
#3
A C Bourgeois, M Edmunds, A Awan, L Jonah, O Varsaneux, W Siu
Background: Human immunodeficiency virus (HIV) continues to be a global public health concern, with 2.1 million people newly infected in 2015. Although many high-income countries have noted decreasing rates of HIV, between 2013 and 2015 Canada's rates had stabilized at 5.8 per 100,000 population. Objective: To provide a descriptive overview of reported cases of HIV in Canada up until 2016 by geographic location, sex, age group, exposure category and race/ethnicity, with a focus on the most recent data...
December 7, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29766721/policy-considerations-for-mobile-biosensors
#4
Steven M Russell, Roberto de la Rica
Meeting policy requirements is essential for advancing molecular diagnostic devices from the laboratory to real-world applications and commercialization. Considering policy as a starting point in the design of new technology is a winning strategy. Rapid developments have put mobile biosensors at the frontier of molecular diagnostics, at times outpacing policymakers, and therefore offering new opportunities for breakthroughs in global health. In this manuscript we survey influential global health policies and recent developments in mobile biosensing in order to gain a new perspective for the future of the field...
May 16, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29757703/hepatitis-b-virus-infection-among-asymptomatic-residents-of-low-income-community-in-ibadan-southwest-nigeria
#5
Adeleye Solomon Bakarey, Oluwaseun Deborah Olaniyan
INTRODUCTION: Hepatitis B Virus (HBV) infection is one of the most infectious diseases worldwide and a major public health concern. In spite of efforts at controlling the scourge globally, HBV continues to thrive in developing countries, such as Nigeria due to ignorance on its mode of transmission and its asymptomatic nature in the populace. Therefore, this community-based study was carried out in Yemetu community in Ibadan, Nigeria to determine the burden of HBV infection among asymptomatic residents of this community...
May 14, 2018: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/29754051/label-free-nano-biosensing-on-the-road-to-tuberculosis-detection
#6
REVIEW
Behrouz Golichenari, Kelly Velonia, Rahim Nosrati, Alireza Nezami, Aref Farokhi-Fard, Khalil Abnous, Javad Behravan, Aristidis M Tsatsakis
Tuberculosis, an ailment caused by the bacterium Mycobacterium tuberculosis (Mtb) complex, is one of the catastrophic transmittable diseases that affect human. Reports published by WHO indicate that in 2017 about 6.3 million people progressed to TB and 53 million TB patients died from 2000 to 2016. Therefore, early diagnosis of the disease is of great importance for global health care programs. Common diagnostics like the traditional PPD test and antibody-assisted assays suffer the lack of sensitivity, long processing time and cumbersome post-test proceedings...
August 15, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29752279/a-comprehensive-study-of-calcific-aortic-stenosis-from-rabbit-to-human-samples
#7
L Mourino-Alvarez, M Baldan-Martin, T Sastre-Oliva, M Martin-Lorenzo, A S Maroto, N Corbacho-Alonso, R Rincon, T Martin-Rojas, L F Lopez-Almodovar, G Alvarez-Llamas, F Vivanco, L R Padial, F de la Cuesta, M G Barderas
The global incidence of calcific aortic stenosis (CAS) is increasing due, in part, to a growing elderly population, and poses a great challenge to public health because of the multiple comorbidities of these patients. Using a rabbit model of CAS, we sought to characterize protein alterations associated with calcified valve tissue that can be ultimately measured in plasma as non-invasive biomarkers of CAS.Aortic valves from healthy and mild stenotic rabbits were analyzed by two-dimensional difference gel electrophoresis, and selected reaction monitoring was used to directly measure the differentially expressed proteins in plasma from the same rabbits to corroborate their potential as diagnostic indicators, and also in plasma from human subjects, to examine their translatability to the clinical setting...
May 10, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29751857/residency-mini-fellowships-in-the-pgy-5-year-is-there-added-value
#8
Anuradha S Shenoy-Bhangle, Ronald L Eisenberg, Tabitha Fineberg, Priscilla J Slanetz
RATIONALE AND OBJECTIVES: With the restructuring of radiology board certification, many residencies created PGY-5 "mini-fellowships," during which residents spend focused time pursuing advanced subspecialty training or developing nonclinical skills in leadership, health policy and health-care economics, education, quality improvement, informatics, research, or global health. We surveyed graduates of an academic diagnostic radiology residency to assess the relative value and impact of PGY-5 mini-fellowships on career satisfaction and success...
June 2018: Academic Radiology
https://www.readbyqxmd.com/read/29749387/invasive-candidiasis
#9
REVIEW
Peter G Pappas, Michail S Lionakis, Maiken Cavling Arendrup, Luis Ostrosky-Zeichner, Bart Jan Kullberg
Invasive candidiasis is an important health-care-associated fungal infection that can be caused by several Candida spp.; the most common species is Candida albicans, but the prevalence of these organisms varies considerably depending on geographical location. The spectrum of disease of invasive candidiasis ranges from minimally symptomatic candidaemia to fulminant sepsis with an associated mortality exceeding 70%. Candida spp. are common commensal organisms in the skin and gut microbiota, and disruptions in the cutaneous and gastrointestinal barriers (for example, owing to gastrointestinal perforation) promote invasive disease...
May 11, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29747601/pregnancy-outcomes-in-women-with-gestational-diabetes-mellitus-diagnosed-according-to-the-who-2013-and-who-1999-diagnostic-criteria-a-multicentre-retrospective-cohort-study
#10
Eva A R Goedegebure, Sarah H Koning, Klaas Hoogenberg, Fleurisca J Korteweg, Helen L Lutgers, Mattheus J M Diekman, Eva Stekkinger, Paul P van den Berg, Joost J Zwart
BACKGROUND: The World Health Organization (WHO) adopted more stringent diagnostic criteria for GDM in 2013, to improve pregnancy outcomes. However, there is no global consensus on these new diagnostic criteria, because of limited evidence. The objective of the study was to evaluate maternal characteristics and pregnancy outcomes in two cohorts in the Netherlands applying different diagnostic criteria for GDM i.e. WHO-2013 and WHO-1999. METHODS: A multicenter retrospective study involving singleton GDM pregnancies in two regions, between 2011 and 2016...
May 10, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29744113/a-case-of-oncogenic-osteomalacia-owing-to-inguinal-tumor
#11
Luiza Tonello, Arthur Paredes Gatti, João Diedrich Neto, Uirá Fernandes Teixeira, Marcos Bertozzi Goldoni, Paulo Roberto Ott Fontes, José Artur Sampaio, Luiz Maraninchi Pereira Lima, Fábio Luiz Waechter
The oncogenic hypophosphatemic osteomalacia is a very incapacitating disease and the mortality rate, mainly due to metabolic disorder, depends on the early diagnosis, since the surgery is curative. The major difficulty is to consider this kind of disease in patients with complex clinical presentation. Moreover, medical centers have to provide a good diagnostic infrastructure because these tumors, in most cases, are small and do not have an obvious site. This case report is about a man with a rapid loss of strength and muscle mass, which had his diagnosis in a late, culminating in significant deformities and organic dysfunctions with clinical repercussions...
October 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29739357/serological-evaluation-for-chagas-disease-in-migrants-from-latin-american-countries-resident-in-rome-italy
#12
Stefania Pane, Maria Letizia Giancola, Pierluca Piselli, Angela Corpolongo, Ernestina Repetto, Rita Bellagamba, Claudia Cimaglia, Stefania Carrara, Piero Ghirga, Alessandra Oliva, Nazario Bevilacqua, Ahmad Al Rousan, Carla Nisii, Giuseppe Ippolito, Emanuele Nicastri
BACKGROUND: Chagas disease (CD) is a systemic parasitic infection caused by the protozoan Trypanosoma cruzi, whose chronic phase may lead to cardiac and intestinal disorders. Endemic in Latin America where it is transmitted mainly by vectors, large-scale migrations to other countries have turned CD into a global health problem because of its alternative transmission routes through blood transfusion, tissue transplantation, or congenital. Aim of this study was to compare the performance of two commercially available tests for serological diagnosis of CD in a group of Latin American migrants living in a non-endemic setting (Rome, Italy)...
May 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29737965/identification-and-characterization-of-a-novel-single-chain-variable-fragment-scfv-antibody-against-neisseria-meningitidis-factor-h-binding-protein-fhbp
#13
Fatemeh Yarian, Bahram Kazemi, Mojgan Bandehpour
PURPOSE: Neisseria meningitidis is the leading global cause of meningitis and sepsis. Detection, followed by identification, of bacterial pathogens is important in medicine and public health. In the present study, we used the ribosome display technique to select single-chain variable fragments (scFv) that are specific to the surface-exposed fHbp antigen of N. meningitidis. METHODOLOGY: The recombinant fHbp protein was used as the antigen for the immunization of BALB/c mice...
May 8, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29730648/metrological-traceability-and-harmonization-of-medical-tests-a-quantum-leap-forward-is-needed-to-keep-pace-with-globalization-and-stringent-ivd-regulations-in-the-21st-century
#14
Christa Cobbaert, Nico Smit, Philippe Gillery
In our efforts to advance the profession and practice of clinical laboratory medicine, strong coordination and collaboration are needed more than ever before. At the dawn of the 21st century, medical laboratories are facing many unmet clinical needs, a technological revolution promising a plethora of better biomarkers, financial constraints, a growing scarcity of well-trained laboratory technicians and a sharply increasing number of International Organization for Standardization guidelines and new regulations to which medical laboratories should comply in order to guarantee safety and effectiveness of medical test results...
May 7, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29726743/opinion-paper-the-role-of-work-in-the-management-of-medically-unexplained-physical-symptoms
#15
Els Tobback, An Mariman, Lies Clauwaert, Lode Godderis, Stefan Heytens, Patrick Ruppol, Daniel Spooren, Rita Tytgat, Martine De Muynck, Dirk Vogelaers
OBJECTIVES: Patients with medically unexplained physical symptoms suffer from chronic fatigue and/or pain in combination with a variety of other symptoms. A flexible, biopsychosocial approach is needed for diagnostic screening and global management. It is crucial to involve the direct patient environment, including family, friends, colleagues as well as health providers, evaluation, and reintegration sector. The aim of this paper is to review the importance of work in the management of medically unexplained physical symptoms...
May 4, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29721826/importance-of-differential-identification-of-mycobacterium-tuberculosis-strains-for-understanding-differences-in-their-prevalence-treatment-efficacy-and-vaccine-development
#16
REVIEW
Hansong Chae, Sung Jae Shin
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a serious global health problem in the 21st century because of its high mortality. Mtb is an extremely successful human-adapted pathogen that displays a multifactorial ability to control the host immune response and to evade killing by drugs, resulting in the breakdown of BCG vaccine-conferred anti-TB immunity and development of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb. Although genetic components of the genomes of the Mtb complex strains are highly conserved, showing over 99% similarity to other bacterial genera, recently accumulated evidence suggests that the genetic diversity of the Mtb complex strains has implications for treatment outcomes, development of MDR/XDR Mtb, BCG vaccine efficacy, transmissibility, and epidemiological outbreaks...
May 2018: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29720251/a-meta-analysis-of-the-prevalence-of-african-animal-trypanosomiasis-in-nigeria-from-1960-to-2017
#17
REVIEW
Paul Olalekan Odeniran, Isaiah Oluwafemi Ademola
BACKGROUND: African animal trypanosomiasis is an economically significant disease that affects the livestock industry in Nigeria. It is caused by several parasites of the genus Trypanosoma. National estimates of the disease prevalence in livestock and tsetse flies are lacking, therefore a systematic review and meta-analysis were performed to understand the trend of the disease prevalence over the years. METHODS: Publications were screened in Web of Science, Ovid MEDLINE, Global Health, EMBASE and PubMed databases...
May 2, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29718439/cholera-under-diagnosis-and-differentiation-from-other-diarrhoeal-diseases
#18
Tristan P Learoyd, Rupert M Gaut
Background: Globally 1.4 billion people are at risk from cholera in countries where the disease is endemic, with an estimated 2.8 million cases annually. The disease is significantly under reported due to economic, social and political disincentives as well as poor laboratory resources and epidemiological surveillance in those regions. In addition, identification of cholera from other diarrhoeal causes is often difficult due to shared pathology and symptoms with few reported cases in travellers from Northern Europe...
May 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29717677/facilitating-earlier-diagnosis-of-cardiovascular-disease-through-point-of-care-biosensors-a-review
#19
Mackenzie M Honikel, Chi-En Lin, David Probst, Jeffrey T La Belle
Cardiovascular disease (CVD) accounts for 30% of all global deaths and is predicted to dominate in the coming years, despite vast improvements in medical technology. Current clinical methods of assessing an individual's cardiovascular health include blood tests to monitor relevant biomarker levels as well as varying imaging modalities such as electrocardiograms, computed tomography, and angiograms to assess vasculature. As informative as these tools are, they each require lengthy scheduling, preparation, and highly trained personnel to interpret the results before any information is accessible to patients, often leading to delayed treatment, which can be fatal...
2018: Critical Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/29715005/nanoparticle-enhanced-plasmonic-biosensor-for-digital-biomarker-detection-in-a-microarray
#20
Alexander Belushkin, Filiz Yesilköy, Hatice Altug
Nanoplasmonic devices have become a paradigm for biomolecular detection enabled by enhanced light-matter interactions in the fields from biological and pharmaceutical research to medical diagnostics and global health. In this work, we present a bright-field imaging plasmonic biosensor that allows visualization of single sub-wavelength gold nanoparticles (NPs) on large-area gold nanohole arrays (Au-NHAs). The sensor generates image heatmaps that reveal the locations of single NPs as high-contrast spikes, enabling the detection of individual nanoparticle-labeled molecules...
May 1, 2018: ACS Nano
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