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https://www.readbyqxmd.com/read/26438534/insights-into-molecular-plasticity-in-protein-complexes-from-trm9-trm112-trna-modifying-enzyme-crystal-structure
#1
Juliette Létoquart, Nhan van Tran, Vonny Caroline, Alexey Aleksandrov, Noureddine Lazar, Herman van Tilbeurgh, Dominique Liger, Marc Graille
Most of the factors involved in translation (tRNA, rRNA and proteins) are subject to post-transcriptional and post-translational modifications, which participate in the fine-tuning and tight control of ribosome and protein synthesis processes. In eukaryotes, Trm112 acts as an obligate activating platform for at least four methyltransferases (MTase) involved in the modification of 18S rRNA (Bud23), tRNA (Trm9 and Trm11) and translation termination factor eRF1 (Mtq2). Trm112 is then at a nexus between ribosome synthesis and function...
December 15, 2015: Nucleic Acids Research
https://www.readbyqxmd.com/read/25625329/two-subunit-enzymes-involved-in-eukaryotic-post-transcriptional-trna-modification
#2
REVIEW
Michael P Guy, Eric M Phizicky
tRNA modifications are crucial for efficient and accurate protein translation, with defects often linked to disease. There are 7 cytoplasmic tRNA modifications in the yeast Saccharomyces cerevisiae that are formed by an enzyme consisting of a catalytic subunit and an auxiliary protein, 5 of which require only a single subunit in bacteria, and 2 of which are not found in bacteria. These enzymes include the deaminase Tad2-Tad3, and the methyltransferases Trm6-Trm61, Trm8-Trm82, Trm7-Trm732, and Trm7-Trm734, Trm9-Trm112, and Trm11-Trm112...
2014: RNA Biology
https://www.readbyqxmd.com/read/21693558/formation-of-m2g6-in-methanocaldococcus-jannaschii-trna-catalyzed-by-the-novel-methyltransferase-trm14
#3
Sheena Menezes, Kirk W Gaston, Kady L Krivos, Ethel E Apolinario, Norbert O Reich, Kevin R Sowers, Patrick A Limbach, John J Perona
The modified nucleosides N(2)-methylguanosine and N(2)(2)-dimethylguanosine in transfer RNA occur at five positions in the D and anticodon arms, and at positions G6 and G7 in the acceptor stem. Trm1 and Trm11 enzymes are known to be responsible for several of the D/anticodon arm modifications, but methylases catalyzing post-transcriptional m(2)G synthesis in the acceptor stem are uncharacterized. Here, we report that the MJ0438 gene from Methanocaldococcus jannaschii encodes a novel S-adenosylmethionine-dependent methyltransferase, now identified as Trm14, which generates m(2)G at position 6 in tRNA(Cys)...
September 1, 2011: Nucleic Acids Research
https://www.readbyqxmd.com/read/21478168/mechanism-of-activation-of-methyltransferases-involved-in-translation-by-the-trm112-hub-protein
#4
Dominique Liger, Liliana Mora, Noureddine Lazar, Sabine Figaro, Julien Henri, Nathalie Scrima, Richard H Buckingham, Herman van Tilbeurgh, Valérie Heurgué-Hamard, Marc Graille
Methylation is a common modification encountered in DNA, RNA and proteins. It plays a central role in gene expression, protein function and mRNA translation. Prokaryotic and eukaryotic class I translation termination factors are methylated on the glutamine of the essential and universally conserved GGQ motif, in line with an important cellular role. In eukaryotes, this modification is performed by the Mtq2-Trm112 holoenzyme. Trm112 activates not only the Mtq2 catalytic subunit but also two other tRNA methyltransferases (Trm9 and Trm11)...
August 2011: Nucleic Acids Research
https://www.readbyqxmd.com/read/19749381/production-of-yeast-m2g10-methyltransferase-trm11-and-trm112-complex-in-a-wheat-germ-cell-free-translation-system
#5
Kazuki Okada, Yuki Muneyoshi, Yaeta Endo, Hiroyuki Hori
Transfer RNA (guanine-N(2)-)-methyltransferase [tRNA (m(2)G10) methyltransferase] catalyzes a methyl-transfer from S-adenosyl-L-methionine to N(2)-atom of guanine at position 10 (G10) in tRNA and generates N(2)-methylguanine at position 10 (m(2)G10). Yeast enzyme contains two protein subunits (Trm11 and Trm112). Trm11 protein is expected to be a catalytic subunit and Trm112 contains a Zinc-finger. In yeast cells, Trm112 binds not only to Trm11 but also to other proteins such as Lys9, Trm9, and Mtq2. Therefore, the Trm112 protein may regulate population of several protein complexes...
2009: Nucleic Acids Symposium Series
https://www.readbyqxmd.com/read/18657261/trna-and-protein-methylase-complexes-mediate-zymocin-toxicity-in-yeast
#6
Patrick Studte, Sabrina Zink, Daniel Jablonowski, Christian Bär, Tobias von der Haar, Mick F Tuite, Raffael Schaffrath
Modification of Saccharomyces cerevisiae tRNA anticodons at the wobble uridine (U34) position is required for tRNA cleavage by the zymocin tRNase killer toxin from Kluyveromyces lactis. Hence, U34 modification defects including lack of the U34 tRNA methyltransferase Trm9 protect against tRNA cleavage and zymocin. Using zymocin as a tool, we have identified toxin-resistant mutations in TRM9 that are likely to affect the U34 methylation reaction. Most strikingly, C-terminal truncations in Trm9 abolish interaction with Trm112, a protein shown to individually purify with Lys9 and two more methylases, Trm11 and Mtq2...
September 2008: Molecular Microbiology
https://www.readbyqxmd.com/read/15899842/trm11p-and-trm112p-are-both-required-for-the-formation-of-2-methylguanosine-at-position-10-in-yeast-trna
#7
Suresh K Purushothaman, Janusz M Bujnicki, Henri Grosjean, Bruno Lapeyre
N(2)-Monomethylguanosine-10 (m(2)G10) and N(2),N(2)-dimethylguanosine-26 (m(2)(2)G26) are the only two guanosine modifications that have been detected in tRNA from nearly all archaea and eukaryotes but not in bacteria. In Saccharomyces cerevisiae, formation of m(2)(2)G26 is catalyzed by Trm1p, and we report here the identification of the enzymatic activity that catalyzes the formation of m(2)G10 in yeast tRNA. It is composed of at least two subunits that are associated in vivo: Trm11p (Yol124c), which is the catalytic subunit, and Trm112p (Ynr046w), a putative zinc-binding protein...
June 2005: Molecular and Cellular Biology
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