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Lateral flow

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https://www.readbyqxmd.com/read/29786447/thickness-tunable-synthesis-of-ultrathin-type-ii-dirac-semimetal-ptte-2-single-crystals-and-their-thickness-dependent-electronic-properties
#1
Huifang Ma, Peng Chen, Bo Li, Jia Li, Ruoqi Ai, Zhengwei Zhang, Guangzhuang Sun, Kangkang Yao, Zhaoyang Lin, Bei Zhao, Ruixia Wu, Xuwan Tang, Xidong Duan, Xiangfeng Duan
The recent discovery of topological semimetals has stimulated extensive research interest due to their unique electronic properties and novel transport properties related to a chiral anomaly. However, the studies to date are largely limited to bulk crystals and exfoliated flakes. Here, we report the controllable synthesis of ultrathin two-dimensional (2D) platinum telluride (PtTe2 ) nanosheets with tunable thickness and investigate the thickness-dependent electronic properties. We show that PtTe2 nanosheets can be readily grown, using a chemical vapor deposition approach, with a hexagonal or triangular geometry and a lateral dimension of up to 80 μm, and the thickness of the nanosheets can be systematically tailored from over 20 to 1...
May 22, 2018: Nano Letters
https://www.readbyqxmd.com/read/29783960/performance-of-oncoe6-cervical-test-with-collection-methods-enabling-self-sampling
#2
Amrei Krings, Anna M Dückelmann, Lutz Moser, Johannes Gollrad, Maarten Wiegerinck, Johannes Schweizer, Andreas M Kaufmann
BACKGROUND: The paradigm shift from cytological screening to Human Papillomavirus (HPV)-based screening for cervical cancer allows the introduction of new technologies in sample collection and diagnostics. The OncoE6™ Cervical Test (OncoE6 Test) is a rapid, easy-to-use lateral flow method detecting HPV16/18 E6 oncoproteins that has proven to detect high-grade cervical lesions with high specificity. If compatible with self-collection samples, this technology might allow for decentralized screening of hard-to-reach populations...
May 21, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29782328/post-stroke-visual-neglect-affects-goal-directed-locomotion-in-different-perceptuo-cognitive-conditions-and-on-a-wide-visual-spectrum
#3
Tatiana Ogourtsova, Philippe S Archambault, Anouk Lamontagne
BACKGROUND: Unilateral spatial neglect (USN), a highly prevalent and disabling post-stroke deficit, has been shown to affect the recovery of locomotion. However, our current understanding of USN role in goal-directed locomotion control, and this, in different cognitive/perceptual conditions tapping into daily life demands, is limited. OBJECTIVES: To examine goal-directed locomotion abilities in individuals with and without post-stroke USN vs. healthy controls. METHODS: Participants (n = 45, n = 15 per group) performed goal-directed locomotion trials to actual, remembered and shifting targets located 7 m away at 0° and 15° right/left while immersed in a 3-D virtual environment...
2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29782027/an-improved-detection-limit-and-working-range-of-lateral-flow-assays-based-on-a-mathematical-model
#4
Zhi Liu, Zhiguo Qu, Ruihua Tang, Xiaocong He, Hui Yang, Dan Bai, Feng Xu
Lateral flow assays (LFAs) have attracted considerable attention in biomedical diagnostics. However, it's still challenging to achieve a high detection sensitivity and extensive working range, mainly because the underlying mechanism of complex reaction processes in LFAs remains unclear. Many mathematical models have been developed to analyze the complex reaction processes, which are only qualitative with limited guidance for LFA design. Now, a semi-quantitative convection-diffusion-reaction model is developed by considering the kinetics of renaturation of nucleic acids and the model is validated by our experiments...
May 21, 2018: Analyst
https://www.readbyqxmd.com/read/29781019/complex-strain-induced-structural-changes-observed-in-fibrin-assembled-in-human-plasma
#5
G Portale, J Torbet
The structure of the core scaffold of blood clots, the interlinked 3-dimensional network of fibrin fibers, is modified by mechanical forces generated by platelet driven clot retraction, wound repair and shear stress through blood flow. Here X-ray diffraction is used to investigate how uniaxial strain, ε (ε = extension/original length), alters fiber structure in highly aligned human plasma clots covalently cross-linked by Factor XIIIa. Three stretch sensitive axially repeating structures are identified. Firstly, the foundation structure with an initial ≈22 nm axial repeat stretches, fades then disappears at ε ≈ 0...
May 21, 2018: Nanoscale
https://www.readbyqxmd.com/read/29779958/development-of-an-anti-epo-antibody-detection-kit-based-on-lab-on-a-chip-and-bridging-antibody-technologies
#6
Jin-Gyo Oh, Jihyun Seong, Sunmi Han, Tae-Hwe Heo
Immunogenicity is a major concern in the use of biological drugs. In particular, antibody-mediated pure red cell aplasia (PRCA) is a rare condition that is caused by administration of recombinant erythropoietin. There are numerous assay platforms for detect EPO anti-drug antibody (ADA), and most have appropriate assay sensitivity, but in need of improvement in terms of assay turnaround time and user accessibility. Here, the new method was developed based on lab-on-a-chip technology and bridging ELISA. The FREND™ Cartridge is equipped with a microfluidic lateral flow channel, enabling easy, fast and accurate immunoassays with small sample volumes...
May 17, 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29773528/a-digital-app-to-aid-detection-monitoring-and-management-of-dyslexia-in-young-children-dimmand-protocol-for-a-digital-health-and-education-solution
#7
Mariam R Sood, Annet Toornstra, Martin I Sereno, Mark Boland, Daniele Filaretti, Anuj Sood
BACKGROUND: Dyslexia, a specific learning difficulty and a disability as defined in the Equality Act 2010, is a lifelong condition that affects a child from the start of education. Dyslexia is characterized by difficulties in language processing (reading, spelling, and writing) which do not correspond with the child's general intellectual abilities. Although dyslexia cannot be cured, there is a consensus that interventions are more effective and have greater impact the earlier they are administered...
May 17, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29773423/management-of-giant-embryonic-vein-in-klippel-tr%C3%A3-naunay-syndrome
#8
Animesh Rathore, Peter Gloviczki, Haraldur Bjarnason
Klippel-Trénaunay syndrome is a rare mixed malformation characterized by congenital varicose veins, low-flow venous and lymphatic malformations, hypertrophy of soft tissue and bone, and capillary malformations. A 35-year-old man with a diagnosis of Klippel-Trénaunay syndrome presented to the clinic with significant pain and swelling in the left leg. Initial conservative management with compression therapy failed. He was then managed surgically with preoperative placement of an inferior vena cava filter (because of a history of deep venous thrombosis and pulmonary embolism), followed by resection of the lateral embryonic vein, ligation of large perforators, and excision of smaller varicosities...
May 14, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29772936/the-effect-of-supine-positioning-on-maternal-hemodynamics-during-late-pregnancy
#9
Aimee Humphries, S Ali Mirjalili, Gregory P Tarr, John M D Thompson, Peter Stone
INTRODUCTION: Recent studies have demonstrated an association between maternal supine sleep position and an increased risk of late stillbirth. During late pregnancy the gravid uterus compresses the inferior vena cava when a woman lies in the supine position. The azygos system of veins is the dominant pathway of collateral venous return back to the heart in the event of acute obstruction of the inferior vena cava. It is suggested that this pathway provides adequate collateral venous circulation in the event of inferior vena caval compression in the supine position during late pregnancy...
May 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29772718/ectromelia-virus-affects-mitochondrial-network-morphology-distribution-and-physiology-in-murine-fibroblasts-and-macrophage-cell-line
#10
Karolina P Gregorczyk, Zbigniew Wyżewski, Joanna Szczepanowska, Felix N Toka, Matylda B Mielcarska, Magdalena Bossowska-Nowicka, Małgorzata Gieryńska, Anna Boratyńska-Jasińska, Justyna Struzik, Marek G Niemiałtowski, Lidia Szulc-Dąbrowska
Mitochondria are multifunctional organelles that participate in numerous processes in response to viral infection, but they are also a target for viruses. The aim of this study was to define subcellular events leading to alterations in mitochondrial morphology and function during infection with ectromelia virus (ECTV). We used two different cell lines and a combination of immunofluorescence techniques, confocal and electron microscopy, and flow cytometry to address subcellular changes following infection. Early in infection of L929 fibroblasts and RAW 264...
May 16, 2018: Viruses
https://www.readbyqxmd.com/read/29772227/evolutionary-shift-towards-lateral-line-dependent-prey-capture-behavior-in-the-blind-mexican-cavefish
#11
Evan Lloyd, Courtney Olive, Bethany A Stahl, James B Jaggard, Paloma Amaral, Erik R Duboue, Alex C Keene
Feeding strategies are dependent on multi-modal sensory processing, that integrates visual, chemosensory, and mechanoreceptive cues. In many fish species, local environments and food availability dramatically influence the evolution of sensory and morphological traits that underlie feeding. The Mexican cavefish, Astyanax mexicanus, have developed robust changes in sensory-dependent behaviors, but the impact on prey detection and feeding behavior is not known. In the absence of eyes, cavefish have evolved enhanced sensitivity of the lateral line, comprised of mechanosensory organs that sense water flow and detect prey...
May 14, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29771787/point-of-care-cryptococcal-antigen-screening-pipetting-finger-prick-blood-improves-performance-of-immuno-mycologics-lateral-flow-assay
#12
Rachel M Wake, Joseph N Jarvis, Thomas S Harrison, Nelesh P Govender
BACKGROUND: Cryptococcal antigen (CrAg) screening at point of care could improve cryptococcal meningitis prevention where laboratory resources are limited. We evaluated the accuracy of Immuno-Mycologics (IMMY, Norman, OK) CrAg lateral flow assay (LFA) using different techniques at point of care. SETTING: Two tertiary-level hospitals in Johannesburg and a community health clinic in Soweto, South Africa. METHODS: A case-control diagnostic validation study, and a prospective clinic-based implementation study using the IMMY CrAg LFA on finger-prick blood...
April 30, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29769531/myosin1d-is-an-evolutionarily-conserved-regulator-of-animal-left-right-asymmetry
#13
Thomas Juan, Charles Géminard, Jean-Baptiste Coutelis, Delphine Cerezo, Sophie Polès, Stéphane Noselli, Maximilian Fürthauer
The establishment of left-right (LR) asymmetry is fundamental to animal development, but the identification of a unifying mechanism establishing laterality across different phyla has remained elusive. A cilia-driven, directional fluid flow is important for symmetry breaking in numerous vertebrates, including zebrafish. Alternatively, LR asymmetry can be established independently of cilia, notably through the intrinsic chirality of the acto-myosin cytoskeleton. Here, we show that Myosin1D (Myo1D), a previously identified regulator of Drosophila LR asymmetry, is essential for the formation and function of the zebrafish LR organizer (LRO), Kupffer's vesicle (KV)...
May 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29768103/efficacy-of-recombinase-polymerase-amplification-to-diagnose-trypanosoma-cruzi-infection-in-dogs-with-cardiac-alterations-from-an-endemic-area-of-mexico
#14
Matilde Jimenez-Coello, Thomas Shelite, Alejandro Castellanos-Gonzalez, Omar Saldarriaga, Rocio Rivero, Antonio Ortega-Pacheco, Carlos Acevedo-Arcique, Karla Amaya-Guardia, Nisha Garg, Peter Melby, Bruno L Travi
Chagas disease is a lingering Public Health problem in Latin America with ∼5.7 million people infected with Trypanosoma cruzi. Transmission is still taking place in most countries of the Americas, including the United States. Dogs are frequently infected with T. cruzi and its high infection prevalence is associated with increased risk of Chagas disease in humans. The city of Mérida in the Yucatan peninsula is endemic for Chagas disease and canines are frequently infected with T. cruzi. The objective of this study was to evaluate the performance of a qualitative point of care (POC) molecular test (RPA-LF, recombinase polymerase amplification-lateral flow) developed in our laboratory for identifying infected dogs...
May 16, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29767351/evaluating-the-methods-used-for-measuring-cerebral-blood-flow-at-rest-and-during-exercise-in-humans
#15
REVIEW
Michael M Tymko, Philip N Ainslie, Kurt J Smith
The first accounts of measuring cerebral blood flow (CBF) in humans were made by Angelo Mosso in ~1880, who recorded brain pulsations in patients with skull defects. In 1890, Charles Roy and Charles Sherrington determined in animals that brain pulsations-assessed via a similar method used by Mosso-were altered during a variety of stimuli including sensory nerve stimulation, asphyxia, and pharmacological interventions. Between 1880 and 1944, measurements for CBF were typically relied on skull abnormalities in humans...
May 16, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29765984/jazf1-inhibits-adipose-tissue-macrophages-and-adipose-tissue-inflammation-in-diet-induced-diabetic-mice
#16
Fanping Meng, Yao Lin, Min Yang, Minyan Li, Gangyi Yang, Po Hao, Ling Li
Background: Juxtaposed with another zinc finger gene 1 (JAZF1) affects gluconeogenesis, insulin sensitivity, lipid metabolism, and inflammation, but its exact role in chronic inflammation remains unclear. This study aimed to examine JAZF1 overexpression in vivo on adipose tissue macrophages (ATMs). Methods: Mouse models of high-fat diet- (HFD-) induced insulin resistance were induced using C57BL/6J and JAZF1-overexpressing (JAZF1-OX) mice. The mice were randomized (8-10/group) to C57BL/6J mice fed regular diet (RD) (NC group), C57BL/6J mice fed HFD (HF group), JAZF1-OX mice fed RD (NJ group), and JAZF1-OX mice fed HFD (HJ group)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29765982/time-course-of-detection-of-human-male-dna-from-stained-blood-sample-on-various-surfaces-by-loop-mediated-isothermal-amplification-and-polymerase-chain-reaction
#17
Panan Kanchanaphum
This study explores determining the sex of humans from blood stains taken from different surfaces and compares the time course of detection with the conventional PCR, Conventional Loop Mediated Isothermal Amplification (LAMP), and LAMP-Lateral Flow Dipstick (LFD). For the DNA templates, 7 male and 7 female blood stained samples were extracted and added to LAMP and PCR reaction solution to amplify the SRY gene. The DNA samples were extracted from the following blood stained materials: cloth, wood, clay, and tile...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29765396/acute-in-stent-thrombosis-after-carotid-angioplasty-and-stenting-a-case-report-and-literature-review
#18
Wei Hu, Li Wang, GuoPing Wang
Background: Based on the results of a recent randomized controlled trial, carotid artery stenting (CAS) was regarded as a relatively safe, less invasive treatment of internal carotid artery stenosis. However, cerebral thromboembolic events are the most common complications of CAS. Especially acute stent thrombosis following CAS will be fatal without prompt diagnosis and revascularization. Case Report: We report a case of acute stent thrombosis in whom carotid revascularization was performed successfully via arterial thrombolysis and balloon postdilation...
April 2018: Interventional Neurology
https://www.readbyqxmd.com/read/29763678/acute-aerobic-exercise-induces-a-preferential-mobilisation-of-plasmacytoid-dendritic-cells-into-the-peripheral-blood-in-man
#19
Frankie F Brown, John P Campbell, Alex J Wadley, James P Fisher, Sarah Aldred, James E Turner
Dendritic cells (DCs) are important sentinel cells of the immune system responsible for presenting antigen to T cells. Exercise is known to cause an acute and transient increase in the frequency of DCs in the bloodstream in humans, yet there are contradictory findings in the literature regarding the phenotypic composition of DCs mobilised during exercise, which may have implications for immune regulation and health. Accordingly, we sought to investigate the composition of DC sub-populations mobilised in response to acute aerobic exercise...
May 12, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29762712/revealing-the-distinct-folding-phases-of-an-rna-three-helix-junction
#20
Alex Plumridge, Andrea M Katz, George D Calvey, Ron Elber, Serdal Kirmizialtin, Lois Pollack
Remarkable new insight has emerged into the biological role of RNA in cells. RNA folding and dynamics enable many of these newly discovered functions, calling for an understanding of RNA self-assembly and conformational dynamics. Because RNAs pass through multiple structures as they fold, an ensemble perspective is required to visualize the flow through fleetingly populated sets of states. Here, we combine microfluidic mixing technology and small angle X-ray scattering (SAXS) to measure the Mg-induced folding of a small RNA domain, the tP5abc three helix junction...
May 14, 2018: Nucleic Acids Research
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