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https://www.readbyqxmd.com/read/27929275/erectile-dysfunction
#1
Karl T Rew, Joel J Heidelbaugh
Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It is common, affecting at least 12 million U.S. men. The five-question International Index of Erectile Function allows rapid clinical assessment of ED. The condition can be caused by vascular, neurologic, psychological, and hormonal factors. Common conditions related to ED include diabetes mellitus, hypertension, hyperlipidemia, obesity, testosterone deficiency, and prostate cancer treatment...
November 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27888135/antihypertensive-effects-of-androgens-in-conscious-spontaneously-hypertensive-rats
#2
Mercedes Perusquía, Nieves Herrera, Mercedes Ferrer, John N Stallone
Androgens are vasoactive steroids that induce acute vasodilation in a number of isolated vascular beds from different species, but the effects of these hormones on systemic blood pressure (BP) have been studied little. Although it has been reported that androgens exert systemic hypotensive effects through peripheral vasodilation in normotensive rats, there have not been any reports of systemic hypotensive effects of androgens in animals with hypertension. This study was designed to evaluate the acute effects of testosterone (TES) and its 5-reduced metabolites on systemic BP in hypertensive rats and to test the hypothesis that hypotestosteronemia may be involved in the pathogenesis of hypertension...
November 23, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27888061/secretory-function-of-ovarian-cells-and-myometrial-contractions-in-cow-are-affected-by-chlorinated-insecticides-chlordane-heptachlor-mirex-in-vitro
#3
Michael Hubert Wrobel, Jaroslaw Mlynarczuk
The aim of the study was to investigate the effect of chlordane, heptachlor and mirex, on hormonal regulation of the force of myometrial contractions. Myometrial, endometrial, granulosa and luteal cells as well as strips of myometrium from non-pregnant cows were incubated with three insecticides at environmentally relevant doses (0.1, 1 or 10ng/ml). None of the insecticides affected the viability of studied cells. Chlordane stimulated, while heptachlor and mirex inhibited, secretion of testosterone and estradiol from granulosa cells as well as secretion of progesterone from luteal cells, respectively...
November 22, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27884790/altered-spermatogenesis-steroidogenesis-and-suppressed-fertility-in-adult-male-rats-exposed-to-genistein-a-non-steroidal-phytoestrogen-during-embryonic-development
#4
R Meena, Ch Supriya, K Pratap Reddy, P Sreenivasula Reddy
This article focuses on the effects of prenatal exposure to genistein on the mother, her pregnancy and reproductive functions of the male progeny, since these issues have ethological relevance in both animals and humans. Pregnant Wistar rats received i.p. injections of genistein at a dose level of 2, 20 or 100 mg/kg body weight daily from 12(th) to 19(th) day of gestation. Male pups from control and genistein exposed animals were weaned and allowed to develop until 100 days of age; however, when they were 90 days old, twelve males from each group were cohabited with untreated 90-day old females for 8 days...
November 21, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27872877/data-on-spermatogenesis-in-rat-males-gestationally-exposed-to-bisphenol-a-and-high-fat-diets
#5
Pheruza Tarapore, Max Hennessy, Dan Song, Jun Ying, Bin Ouyang, Vinothini Govindarajah, Yuet-Kin Leung, Shuk-Mei Ho
This data article contains supporting information regarding the research article entitled "High butter-fat diet and bisphenol A additively impair male rat spermatogenesis" (P. Tarapore, M. Hennessy, D. Song, J. Ying, B. Ouyang, V. Govindarajah, et al.,) [1]. Sprague-Dawley females were fed AIN, high fat butter, 17α-ethinyl estradiol, or high fat butter plus four bisphenol A doses (2500 µg/kg bw-d, 250 µg/kg bw-d, 25 µg/kg bw-d, and 2.5 µg/kg bw-d) before and during pregnancy. All diets were switched to AIN after the pups were born...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27817037/effect-of-body-mass-index-on-the-outcomes-of-controlled-ovarian-hyperstimulation-in-chinese-women-with-polycystic-ovary-syndrome-a-multicenter-prospective-observational-study
#6
Yan Sheng, Guangxiu Lu, Jiayin Liu, Xiaoyan Liang, Yanping Ma, Xuehong Zhang, Songying Zhang, Yingpu Sun, Yun Sun, Wenfeng Chen, Wenhui Fang, Zijiang Chen
PURPOSE: The purpose of the present study is to explore the influence of body mass index (BMI) on outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) techniques in Chinese women with polycystic ovary syndrome (PCOS). METHODS: This was a multicenter, prospective, observational study that enrolled 800 subjects with PCOS from nine hospitals in China. Patients were categorized according to BMI categories: underweight, <18.5 kg/m(2); normal, 19-23...
November 5, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27805753/dehydroepiandrosterone-dhea-heightens-aggression-and-increases-androgen-receptor-and-aromatase-mrna-expression-in-the-brain-of-a-male-songbird
#7
Douglas W Wacker, Sahar Khalaj, Lindsey J Jones, Tara L Champion, Jason E Davis, Simone L Meddle, John C Wingfield
Dehydroepiandrosterone, DHEA, is a testosterone/estrogen precursor and known modulator of vertebrate aggression. Male song sparrows (Melospiza melodia morphna) show high aggression during breeding and non-breeding life history stages when circulating DHEA levels are high, and low aggression during molt when DHEA levels are low. We previously showed that androgen receptor and aromatase mRNA expression are higher during breeding and/or non-breeding in brain regions associated with reproductive and aggressive behavior, but DHEA's potential role in mediating these seasonal changes remained unclear...
November 2, 2016: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/27788270/testicular-steroidogenesis-and-locomotor-activity-are-regulated-by-gonadotropin-inhibitory-hormone-in-male-european-sea-bass
#8
José A Paullada-Salmerón, Mairi Cowan, María Aliaga-Guerrero, José F López-Olmeda, Evaristo L Mañanós, Silvia Zanuy, José A Muñoz-Cueto
Gonadotropin-inhibitory hormone (GnIH) is a neurohormone that suppresses reproduction by acting at both the brain and pituitary levels. In addition to the brain, GnIH may also be produced in gonads and can regulate steroidogenesis and gametogenesis. However, the function of GnIH in gonadal physiology has received little attention in fish. The main objective of this study was to evaluate the effects of peripheral sbGnih-1 and sbGnih-2 implants on gonadal development and steroidogenesis during the reproductive cycle of male sea bass (Dicentrarchus labrax)...
2016: PloS One
https://www.readbyqxmd.com/read/27769009/role-of-g-protein-coupled-estrogen-receptor-1-in-estradiol-17%C3%AE-induced-alterations-in-protein-synthesis-and-protein-degradation-rates-in-fused-bovine-satellite-cell-cultures
#9
E Kamanga-Sollo, K J Thornton, M E White, W R Dayton
In feedlot steers, estradiol-17β (E2) and combined E2 and trenbolone acetate (a testosterone analog) implants enhance rate and efficiency of muscle growth; and, consequently, these compounds are widely used as growth promoters in several countries. Treatment with E2 stimulates protein synthesis rate and suppresses protein degradation rate in fused bovine satellite cell (BSC) cultures; however, the mechanisms involved in these effects are not known with certainty. Although the genomic effects of E2 mediated through the classical estrogen receptors have been characterized, recent studies indicate that binding of E2 to the G protein-coupled estrogen receptor (GPER)-1 mediates nongenomic effects of E2 on cellular function...
January 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27764533/signaling-events-associated-with-gonadotropin-releasing-hormone-agonist-induced-hormonal-castration-and-its-reversal-in-canines
#10
Ahmed Bulldan, Mazen Shihan, Sandra Goericke-Pesch, Georgios Scheiner-Bobis
A gonadotropin-releasing hormone agonist (GnRH-A) implant induces hormonal castration in dogs that is associated with reduced prostate and testes size. We address the molecular events associated with hormonal castration by examining GnRH-A effects on expression and phosphorylation of a number of key signaling proteins. Male beagles were treated for 5 months with a GnRH-A implant, and then surgically castrated at 0, 3, 6, 12, and 24 weeks after implant removal; untreated animals served as controls. GnRH-A treatment led to activation of c-Raf, Erk1/2, and p53 in the testes...
October 20, 2016: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/27714794/pubertal-pair-housing-facilitates-adult-sexual-behavior-in-male-rats
#11
Heather A Molenda-Figueira, Margaret R Bell, Kayla C De Lorme, Cheryl L Sisk
This study examined the effects of pubertal testosterone (T) and social housing manipulations on male sexual behavior in adult rats. Prepubertal rats were castrated at 21 days of age (P21) and implanted with either blank or T-releasing pellets. At the onset of puberty, P28, half the rats in each treatment group were either single- or pair-housed with a male of the same hormone condition through P56, at which time pellets were removed and all rats were single-housed. In adulthood (P84), all rats received T replacement and were tested for sexual behavior...
October 7, 2016: Developmental Psychobiology
https://www.readbyqxmd.com/read/27663363/experimental-elevation-of-wildlife-testosterone-using-silastic-tube-implants
#12
Efrat Koresh, Devorah Matas, Lee Koren
Testosterone (T) is a key androgen that mediates vertebrate molecular, cellular, and behavioral processes. Its manipulation is therefore of interest to a vast number of researchers studying animal behavior and reproduction, among others. Here, the usage of silastic implants across wildlife species is reviewed, and a method to manipulate rock hyrax (Procavia capensis) testosterone levels using silastic implants is presented. Using a series of in-vitro and in-vivo experiments, the secretion patterns of silastic tubes and silastic glue were tested and were surprisingly found to be similar...
October 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27658648/high-butter-fat-diet-and-bisphenol-a-additively-impair-male-rat-spermatogenesis
#13
Pheruza Tarapore, Max Hennessy, Dan Song, Jun Ying, Bin Ouyang, Vinothini Govindarajah, Yuet-Kin Leung, Shuk-Mei Ho
Exposure to xenoestrogens is a probable cause of male infertility in humans. Consumption of high-fat diets and exposure to bisphenol A (BPA) is pervasive in America. Here, we test the hypothesis that gestational exposure to high dietary fats and/or BPA disrupt spermatogenesis in adulthood. Sprague-Dawley rats were fed diets containing 10kcal% butter fat (AIN), 39kcal% butter fat (HFB), or 39kcal% olive oil (HFO), with or without BPA (25μg/kg body weight/day) during pregnancy. One group of male offspring received testosterone (T)- and estradiol-17β (E2)-filled implants or sham-implants from postnatal day (PND)70-210...
September 19, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27604242/ovarian-reserve-in-women-with-a-previous-history-of-severe-pre-eclampsia
#14
Priya Bhide, Åse Vårtun, Berit Aune, Kari Flo, Purusotam Basnet, Ganesh Acharya
PURPOSE: Severe pre-eclampsia affects maternal health with long-term consequences. It is postulated that during the process of implantation and cell differentiation, embryos resulting from the fertilization of ageing oocytes produce malfunctioning trophoectoderm leading to placental dysfunction. Therefore, severe pre-eclampsia may be associated with a decreased ovarian reserve. The objective of this study was to compare serum markers of ovarian reserve and function between women who had severe pre-eclampsia and those who had normal pregnancies...
September 7, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27591121/transplantation-of-alginate-encapsulated-seminiferous-tubules-and-interstitial-tissue-into-adult-rats-leydig-stem-cell-differentiation-in%C3%A2-vivo
#15
Haolin Chen, Shiying Jin, Shengsong Huang, Janet Folmer, June Liu, Renshan Ge, Barry R Zirkin
In vivo and in vitro studies were conducted to determine whether testosterone-producing Leydig cells are able to develop from cells associated with rat seminiferous tubules, interstitium, or both. Adult rat seminiferous tubules and interstitium were isolated, encapsulated separately in alginate, and implanted subcutaneously into castrated rats. With implanted tubules, serum testosterone increased through two months. Tubules removed from the implanted rats and incubated with LH produced testosterone, and cells on the tubule surfaces expressed steroidogenic enzymes...
November 15, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27450351/low-serum-testosterone-level-predisposes-to-artificial-urinary-sphincter-cuff-erosion
#16
Matthias D Hofer, Allen F Morey, Kunj Sheth, Timothy J Tausch, Jordan Siegel, Billy H Cordon, Matthew I Bury, Earl Y Cheng, Arun K Sharma, Chris M Gonzalez, William E Kaplan, Nicholas L Kavoussi, Alexandra Klein, Claus G Roehrborn
OBJECTIVE: To examine the association between decreased serum testosterone levels and AUS cuff erosion. METHODS: We evaluated serum testosterone levels in 53 consecutive patients. Low testosterone was defined as <280 ng/dl and found in 30/53 patients (56.6%). Chi-square and Student's t tests, Kaplan-Meier analysis, binary logistic regression and Cox regression analysis were used to determine statistical significance. RESULTS: Nearly all men with AUS cuff erosions had low serum testosterone (18/20, 90...
July 20, 2016: Urology
https://www.readbyqxmd.com/read/27368147/aromatized-testosterone-attenuates-contextual-generalization-of-fear-in-male-rats
#17
Joseph F Lynch, Tyler Vanderhoof, Patrick Winiecki, Maeson S Latsko, David C Riccio, Aaron M Jasnow
Generalization is a common symptom of many anxiety disorders, and females are 60% more likely to suffer from an anxiety disorder than males. We have previously demonstrated that female rats display significantly accelerated rates of contextual fear generalization compared to male rats; a process driven, in part, by activation of ERβ. The current study was designed to determine the impact of estrogens on contextual fear generalization in male rats. For experiment 1, adult male rats were gonadectomized (GDX) and implanted with a capsule containing testosterone proprionate, estradiol, dihydrotestosterone proprionate (DHT), or an empty capsule...
August 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27356573/effect-of-copulation-on-potentially-precancerous-prostate-lesions-serum-testosterone-and-prolactin-levels-in-rats
#18
D Herrera-Covarrubias, M B Tecamachaltzi-Silvaran, M Barradas-Moctezuma, J B Rosales-Raya, J Manzo, L I García, G E Aranda-Abreu, N Ismail, G A Coria-Avila, M E Hernández
UNLABELLED: The prostate is an exocrine reproductive gland that participates in ejaculation and it is prone to diseases, including cancer. AIM: In the pre-sent study, we assessed the long-term effects of copulation on the development of precancerous lesions in rats, and compared them with testosterone-induced prostatic lesions. MATERIALS AND METHODS: One group of Wistar males was given 10 copulatory sessions to one ejaculation with ovariectomized, hormone-primed females...
June 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27352640/sperm-quality-and-fertility-in-rats-after-prenatal-exposure-to-low-doses-of-tcdd-a-three-generation-study
#19
Marciana Sanabria, Maira Smaniotto Cucielo, Marina Trevizan Guerra, Cibele Dos Santos Borges, Thais Petrochelli Banzato, Juliana Elaine Perobelli, Gabriel Adan Araújo Leite, Janete Aparecida Anselmo-Franci, Wilma De Grava Kempinas
Exposure to Tetrachlorodibenzo-p-Dioxin (TCDD) in male rats promotes, decreased sperm concentration, alterations in motility and in sperm transit time. We evaluated the effect transgenerational of in utero exposure to low doses TCDD in the sperm quality. Pregnant rats (F0) were exposed to 0.1; 0.5 and 1.0μg of TCDD, on gestational day 15, coincides with the end of most organogenesis in the fetus. Adult male offspring (F1, F2 and F3 generation) were investigated for fertility after artificial insemination in utero...
June 25, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27293533/sustained-administration-of-hormones-exploiting-nanoconfined-diffusion-through-nanochannel-membranes
#20
Thomas Geninatti, R Lyle Hood, Giacomo Bruno, Priya Jain, Eugenia Nicolov, Arturas Ziemys, Alessandro Grattoni
Implantable devices may provide a superior means for hormone delivery through maintaining serum levels within target therapeutic windows. Zero-order administration has been shown to reach an equilibrium with metabolic clearance, resulting in a constant serum concentration and bioavailability of released hormones. By exploiting surface-to-molecule interaction within nanochannel membranes, it is possible to achieve a long-term, constant diffusive release of agents from implantable reservoirs. In this study, we sought to demonstrate the controlled release of model hormones from a novel nanochannel system...
August 2015: Materials
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