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https://www.readbyqxmd.com/read/29573376/chicken-or-egg-outcomes-of-experimental-manipulations-of-maternally-transmitted-hormones-depend-on-administration-method-a-meta-analysis
#1
Edyta Podmokła, Szymon M Drobniak, Joanna Rutkowska
Steroid hormones are important mediators of prenatal maternal effects in animals. Despite a growing number of studies involving experimental manipulation of these hormones, little is known about the impact of methodological differences among experiments on the final results expressed as offspring traits. Using a meta-analytical approach and a representative sample of experimental studies performed on birds, we tested the effect of two types of direct hormonal manipulations: manipulation of females (either by implantation of hormone pellets or injection of hormonal solutions) and manipulation of eggs by injection...
March 24, 2018: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/29471436/antiandrogen-treatment-ameliorates-reproductive-and-metabolic-phenotypes-in-the-letrozole-induced-mouse-model-of-pcos
#2
Genevieve E Ryan, Shaddy Malik, Pamela L Mellon
Polycystic ovary syndrome (PCOS), the most common endocrinopathy in women of reproductive age, is characterized by hyperandrogenism, anovulation, and polycystic ovaries. Although its etiology is unknown, excess androgens are thought to be a critical factor driving the pathology of PCOS. We previously demonstrated that continuous exposure to the aromatase inhibitor letrozole (LET) in mice produces many hallmarks of PCOS, including elevated testosterone (T) and luteinizing hormone, anovulation, and obesity. In the current study, we sought to determine whether androgen receptor (AR) actions are responsible for any of the phenotypes observed in LET mice...
April 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29446829/injection-testosterone-and-adverse-cardiovascular-events-a-case-crossover-analysis
#3
J Bradley Layton, Dongmei Li, Christoph R Meier, Julie L Sharpless, Til Stürmer, M Alan Brookhart
CONTEXT: Exogenous testosterone administration may affect blood clotting, polycythaemia, and may increase atherosclerosis, though any association with cardiovascular events is unclear. While the literature is inconclusive, some studies have suggested testosterone use may increase short-term risk of cardiovascular events and stroke, and injection testosterone may convey higher risks than other dosage forms. OBJECTIVE: We sought to evaluate the short-term cardiovascular risk of receiving injection testosterone...
May 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29425672/an-increase-in-estradiol-facilitates-the-onset-of-paternal-behavior-in-the-dwarf-hamster-phodopus-campbelli
#4
Luis Romero-Morales, Martín Martínez-Torres, Mario Cárdenas, Carmen Álvarez, Agustín Carmona, Benita Cedillo, Eduardo Loya-Zurita, Juana Luis
In the dwarf hamster (Phodopus campbelli), activational effects of testosterone (T) and estradiol (E2 ) in the regulation of paternal behavior have been repeatedly rejected because peripheral concentrations of E2 do not change across the reproductive cycle of males. Further, castration no affected paternal behavior despite that both T and E2 concentrations decreased significantly. However, the role of these hormones has not been evaluated in models of castration and hormonal replacement in virgin males. Here, we analysed the effects of E2 and T in paternal behavior in virgin male dwarf hamster (Phodopus campbelli)...
March 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29284780/stress-during-puberty-facilitates-precancerous-prostate-lesions-in-adult-rats
#5
D Herrera-Covarrubias, G Coria-Avila, M E Hernandez, N Ismail
Puberty can be a critical period for the long-term development of diseases, especially for stress-related disorders that depend on neuroendocrine and immune responses. Some organs like the prostate are prone to diseases that result from neuroendocrine or immune challenges, such as cancer. AIM: In the present study, we assessed the long-term effects of an acute pubertal stressor (immune-challenge) on the development of precancerous lesions in adult rats, and compared them with testosterone-induced prostatic lesions...
December 2017: Experimental Oncology
https://www.readbyqxmd.com/read/29205178/association-of-subcutaneous-testosterone-pellet-therapy-with-developing-secondary-polycythemia
#6
Katherine Lang Rotker, Michael Alavian, Bethany Nelson, Grayson L Baird, Martin M Miner, Mark Sigman, Kathleen Hwang
A variety of methods for testosterone replacement therapy (TRT) exist, and the major potential risks of TRT have been well established. The risk of developing polycythemia secondary to exogenous testosterone (T) has been reported to range from 0.4% to 40%. Implantable T pellets have been used since 1972, and secondary polycythemia has been reported to be as low as 0.4% with this administration modality. However, our experience has suggested a higher rate. We conducted an institutional review board-approved, single-institution, retrospective chart review (2009-2013) to determine the rate of secondary polycythemia in 228 men treated with subcutaneously implanted testosterone pellets...
March 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29190387/chronic-hyperandrogenemia-in-the-presence-and-absence-of-a-western-style-diet-impairs-ovarian-and-uterine-structure-function-in-young-adult-rhesus-monkeys
#7
Cecily V Bishop, Emily C Mishler, Diana L Takahashi, Taylor E Reiter, Kise R Bond, Cadence A True, Ov D Slayden, Richard L Stouffer
STUDY QUESTION: Does chronic hyperandrogenemia beginning at menarche, in the absence and presence of a western-style diet (WSD), alter ovarian and uterine structure-function in young adult rhesus monkeys? SUMMARY ANSWER: Phenotypic alterations in ovarian and uterine structure/function were induced by exogenous testosterone (T), and compounded in the presence of a WSD (T+WSD). WHAT IS KNOWN ALREADY: Hyperandrogenemia is a well-established component of PCOS and is observed in adolescent girls, indicating a potential pubertal onset of disease symptoms...
January 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29155264/modulation-of-adrenal-steroidogenesis-by-testosterone-in-the-lizard-coleonyx-elegans
#8
Rocco V Carsia, Patrick J McIlroy, Henry B John-Alder
Our previous work with adrenocortical cells from several Sceloporus lizard species suggests that gonadal hormones influence the steroidogenic capacity and the sensitivity to ACTH. However, there are discrepancies in these cellular response parameters suggesting that the effects of gonadal hormones on adrenocortical function vary with species, sex, age, season, and environmental/experimental conditions. To gain further insight into these complex interactions, here we report studies on Coleonyx elegans, Eublepharidae (Yucatán Banded Gecko), which is only distantly related to Sceloporus lizards via a basal common ancestor and in captivity, reproduces throughout the year...
April 1, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29145710/testosterone-replacement-in-transgenic-sickle-cell-mice-controls-priapic-activity-and-upregulates-pde5-expression-and-enos-activity-in-the-penis
#9
B Musicki, S Karakus, W Akakpo, F H Silva, J Liu, H Chen, B R Zirkin, A L Burnett
Sickle cell disease (SCD)-associated priapism is characterized by decreased nitric oxide (NO) signaling and downregulated phosphodiesterase (PDE)5 protein expression and activity in the penis. Priapism is also associated with testosterone deficiency, but molecular mechanisms underlying testosterone effects in the penis in SCD are not known. Given the critical role of androgens in erection physiology and NO synthase (NOS)/PDE5 expression, we hypothesized that testosterone replacement to eugonadal testosterone levels reduces priapism by reversing impaired endothelial (e)NOS activity and molecular abnormalities involving PDE5...
January 2018: Andrology
https://www.readbyqxmd.com/read/29134715/relationship-between-follicular-volume-and-oocyte-competence-blastocyst-development-and-live-birth-rate-optimal-follicle-size-for-oocyte-retrieval
#10
B Wirleitner, J Okhowat, L Vištejnová, M Králíčková, M Karlíková, P Vanderzwalmen, F Ectors, L Hradecký, M Schuff, M Murtinger
OBJECTIVE: To analyze oocyte competence in gonadotropin-releasing hormone agonist (GnRHa) stimulation cycles with regard to maturity, fertilization and blastocyst rate, as well as clinical outcome (pregnancy and live-birth rate), in relation to follicular volume, measured by three-dimensional transvaginal sonography (3D-TVS), and follicular fluid composition. METHODS: This was a prospective single-center study conducted between June 2012 and June 2014, including 118 ovum pick-ups with subsequent embryo transfer...
January 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29095270/pituitary-insufficiency-following-traumatic-thoracic-injury-in-an-adolescent-male-patient-a-case-report-and-literature-review
#11
REVIEW
Aleksandra Gilis-Januszewska, Łukasz Kluczyński, Małgorzata Wilusz, Jacek Pantofliński, Renata Turek-Jabrocka, Dorota Pach, Alicja Hubalewska-Dydejczyk
RATIONALE: Traumatic thoracic injuries in adolescents are rare but could be connected with traumatic brain injuries (TBI) and development of chronic hypopituitarism. Early recognition of these endocrine problems is a significant challenge to clinicians. We present difficulties in diagnosis of hypothalamic-pituitary insufficiency following traumatic thoracic injury in adolescence. We also review the literature of similar cases. PATIENT CONCERNS: We present a case of a 24-years-old male...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29059600/17%C3%AE-methyltestosterone-implants-accelerate-spermatogenesis-in-common-snook-centropomus-undecimalis-during-first-sexual-maturation
#12
Gabriel Passini, Fabio Carneiro Sterzelecki, Cristina Vaz Avelar de Carvalho, Manecas Francisco Baloi, Virginia Naide, Vinicius Ronzani Cerqueira
The common snook, Centropomus undecimalis, is an emerging species for intensive fish culture, however, some reproductive aspects of this species, especially the development of the testes and the action of androgen hormones on spermatogenesis have not been studied. The objective of this study was to evaluate the effects of 17α-methyltestosterone (MT) on spermatogenesis and steroidogenesis during the first sexual maturation of the common snook. The fish, which were reproduced in captivity, had a body weight of 305...
October 16, 2017: Theriogenology
https://www.readbyqxmd.com/read/28956719/arsenic-trioxide-exposure-impairs-testicular-morphology-in-adult-male-mice-and-consequent-fetus-viability
#13
Raquel Frenedoso da Silva, Cibele Dos Santos Borges, Celina de Almeida Lamas, Valéria Helena Alves Cagnon, Wilma de Grava Kempinas
The acute promyelocytic leukemia (APL) is a rare disease, affecting 0.1/100,000 individuals globally. Despite significant advances in APL therapy, some patients still experience relapsed disease. Currently, arsenic trioxide (As2 O3 ) was found to be effective in relapsed APL treatment and considered as standard treatment for these cases. However, it has been shown that exposure to As2 O3 may exert adverse effects on the male reproductive system since this substance might also induce apoptosis of other important cell types including stem cells...
2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28956487/effects-of-deslorelin-acetate-on-plasma-testosterone-concentrations-in-captive-yellow-bellied-sliders-trachemys-scripta-sp
#14
Romain Potier, Emma Monge, Tatiana Loucachevsky, Robert Hermes, Frank Göritz, Daphné Rochel, Emmanuel Risi
In Europe, the yellow-bellied slider (Trachemys scripta sp.) is a non-native species in competition with native freshwater turtles. Research on contraception could be useful to control the captive population. Identifying a method of contraception in chelonians would potentially help to control aggression in other chelonian species. The objective of the current study was to evaluate the effects of a single 4.7-mg deslorelin acetate implant on plasma testosterone concentrations in yellow-bellied sliders (Trachemys scripta sp...
September 2017: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/28954214/changes-in-plasma-aldosterone-and-electrolytes-levels-kidney-epithelial-sodium-channel-enac-and-blood-pressure-in-normotensive-wky-and-hypertensive-shr-rats-following-gonadectomy-and-chronic-testosterone-treatment
#15
Su Yi Loh, Nelli Giribabu, Naguib Salleh
We hypothesized that testosterone-induced increase in blood pressure involve changes in aldosterone levels and expression of epithelial sodium channel (ENaC) in the kidneys. METHODS: Ovariectomized female normotensive Wistar Kyoto (WKY) and Spontaneous hypertensive (SHR) rats were given six weeks treatment with testosterone via subcutaneous silastic implant. The rats were anesthetized and mean arterial pressure (MAP) was measured via direct cannulation of the carotid artery. Animals were sacrificed and kidneys were removed and subjected for α, β and γ-ENaC protein and mRNA expression analyses by Western blotting and Real-time polymerase chain reaction (qPCR), respectively...
September 24, 2017: Steroids
https://www.readbyqxmd.com/read/28912255/sex-hormones-and-the-development-of-sexual-size-dimorphism-dihydrotestosterone-inhibits-growth-in-a-female-larger-lizard-sceloporus-undulatus
#16
Nicholas B Pollock, Stephanie Feigin, Marko Drazenovic, Henry B John-Alder
Sexual differences in adult body size (sexual size dimorphism; SSD) and color (sexual dichromatism) are widespread, and both male- and female-biased dimorphisms are observed even among closely related species. A growing body of evidence indicates testosterone (T) can regulate growth, thus the development of SSD, and sexual dichromatism. However, the mechanism(s) underlying these effects are conjectural, including possible conversions of T to estradiol (E2) or 5 α-dihydrotestosterone (DHT). In the present study, we hypothesized that effects of T are physiological responses mediated by androgen receptors, and we tested two specific predictions: 1) that DHT would mimic effects of T by inhibiting growth and enhancing coloration, and 2) that removal of endogenous T via surgical castration would stimulate growth...
September 14, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28854721/chronic-combined-hyperandrogenemia-and-western-style-diet-in-young-female-rhesus-macaques-causes-greater-metabolic-impairments-compared-to-either-treatment-alone
#17
C A True, D L Takahashi, S E Burns, E C Mishler, K R Bond, M C Wilcox, A R Calhoun, L A Bader, T A Dean, N D Ryan, O D Slayden, J L Cameron, R L Stouffer
STUDY QUESTION: Does developmental exposure to the combination of hyperandrogenemia and western-style diet (WSD) worsen adult metabolic function compared to either treatment alone? SUMMARY ANSWER: Young female rhesus macaques treated for 3 years, beginning at menarche, with combined testosterone (T) and WSD have increased weight gain and insulin resistance compared to controls and animals treated with either T or WSD alone. WHAT IS KNOWN ALREADY: Hyperandrogenemia is a well-established component of polycystic ovary syndrome (PCOS) and can be observed in peripubertal girls, indicating a potential pubertal onset of the disease...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28854720/combined-androgen-excess-and-western-style-diet-accelerates-adipose-tissue-dysfunction-in-young-adult-female-nonhuman-primates
#18
Oleg Varlamov, Cecily V Bishop, Mithila Handu, Diana Takahashi, Sathya Srinivasan, Ashley White, Charles T Roberts
STUDY QUESTION: What are the separate and combined effects of mild hyperandrogenemia and consumption of a high-fat Western-style diet (WSD) on white adipose tissue (WAT) morphology and function in young adult female nonhuman primates? SUMMARY ANSWER: Combined exposure to mild hyperandrogenemia and WSD induces visceral omental (OM-WAT) but not subcutaneous (SC-WAT) adipocyte hypertrophy that is associated with increased uptake and reduced mobilization of free fatty acids...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28830748/effects-of-androgens-on-the-leptin-system-in-immature-male-atlantic-salmon-parr
#19
S Trombley, A Rocha, B Th Björnsson, B Borg, M Schmitz
Leptin modulates all levels of the reproductive endocrine axis in mammals, and in turn, both leptin and the leptin receptor are regulated by sex steroids. The aim of this study was to investigate if sex steroids regulate the leptin system also in fish. Immature one-year old male Atlantic salmon parr were implanted with Silclear capsules that were either empty or filled with 11-ketoandrostenedione (11KA) or testosterone (T) and the effects of 35-days treatment were investigated on measures of maturation, gene expression of leptin (lepa1, lepa2), leptin receptor (lepra1) and circulating plasma leptin...
February 1, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28763467/effects-of-tnf-%C3%AE-on-penile-structure-alteration-in-rats-with-hyperprolactinemia
#20
Zhong-Lin Wang, Ling-Yu Yang, Hong-Huan Chen, Hsiao-Hsin Lin, Yi-Ting Tsai, William J Huang
This study aimed to investigate the effects of anti-tumor necrosis factor (TNF)-α antibody (Ab) on alteration of penile structure in the hyperprolactinemia (hyperPRL) rat model. HyperPRL was induced in 8-week-old male Sprague-Dawley rats by allografting anterior pituitary (AP) glands under the renal capsule (+AP rats). Rats implanted with cerebral cortex (CX) were used as sham control (+CX rats). At 6 weeks post implantation, rats received either a single intra-testicular dose of TNF-α Ab (12.5 μg/kg) or testosterone replacement (2 doses of testosterone enanthate [TE], 3 mg/kg), and they were sacrificed 1 week later...
2017: PloS One
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