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https://www.readbyqxmd.com/read/28073285/muscle-nerve-muscle-grafting-for-facial-reanimation-in-rats
#1
Steven J Charous, Jeffery M Hotaling, Bridget D Burgess, Joshua M Sappington, James Park, Grant Turek, Eileen M Foecking
OBJECTIVE: Facial paralysis is a devastating condition leaving patients with a myriad of aesthetic and functional consequences. Muscle-nerve-muscle (MNM) neurotization is a reinnervation technique that involves implanting an autogenous nerve graft as a conduit between an innervated "donor" muscle and a denervated "recipient" muscle. We investigated the use of MNM reinnervation, alone or in combination with electrical stimulation (ES) and testosterone propionate (TP) in comparison to nerve reanastomosis (RE), on functional recovery following rat facial nerve injury...
January 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28064108/protection-of-male-reproductive-toxicity-in-rats-exposed-to-di-n-butyl-phthalate-during-embryonic-development-by-testosterone
#2
Nelli Giribabu, Pamanji Sreenivasula Reddy
Di-n-butyl phthalate (DBP) widely spread industrial chemical that made drastic alteration in male reproductive system. The present study elucidates the protective role of testosterone on reproductive toxicity in prenatal DBP exposed adult male rats. Pregnant rats were injected with corn oil or 100 and 500mg/kg body weight of DBP on gestation day (GD) 1, 7 and 14. F1 male rats were weaned, injected with either testosterone or vehicle. On postnatal day (PND) 100 F1 adult male rats were cohabited with untreated female rats...
January 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28025851/long-term-effects-of-gnrh-agonists-on-fertility-and-behaviour
#3
S Goericke-Pesch
This review aimed to summarize the present knowledge about the effects of GnRH agonist slow-release implants (GnRH A-SRI) on fertility and behaviour in male and female dogs and cats with special focus on deslorelin. Following an initial stimulation of gonadotropin and testosterone secretion possibly associated with an improved semen quality, GnRH A-SRI induce long-term depression of fertility in male dogs and cats with, however, a large individual variation in onset and duration of efficacy especially in cats...
December 27, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28024269/aromatase-changes-in-depression-a-postmortem-and-animal-experimental-study
#4
Juan-Li Wu, Yang He, Radovan Hrubý, Rawien Balesar, Yang-Jian Qi, Lei Guo, Zhong Ren, Qiong-Bin Zhu, Man-Li Huang, Dick F Swaab, Ai-Min Bao
A hyperactive hypothalamo-pituitary-adrenal (HPA) axis is a prominent feature in depression. It has been shown that androgens inhibit HPA activity and that estrogens stimulate it. We have therefore investigated, in human postmortem hypothalamus, whether depression features an increase in aromatase, which is the rate-limiting enzyme for the conversion of androgens to estrogens. In addition, we have tested the effect of an aromatase inhibitor on depression-like symptoms in a frequently used animal model for depression...
November 30, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28007657/aging-and-estradiol-effects-on-gene-expression-in-the-medial-preoptic-area-bed-nucleus-of-the-stria-terminalis-and-posterodorsal-medial-amygdala-of-male-rats
#5
Victoria L Nutsch, Margaret R Bell, Ryan G Will, Weiling Yin, Andrew Wolfe, Ross Gillette, Juan M Dominguez, Andrea C Gore
Studies on the role of hormones in male reproductive aging have traditionally focused on testosterone, but estradiol (E2) also plays important roles in the control of masculine physiology and behavior. Our goal was to examine the effects of E2 on the expression of genes selected for E2-sensitivity, involvement in behavioral neuroendocrine functions, and impairments with aging. Mature adult (MAT, 5 mo) and aged (AG, 18 mo) Sprague-Dawley male rats were castrated, implanted with either vehicle or E2 subcutaneous capsules, and euthanized one month later...
December 20, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27989489/testosterone-pellet-implantation-practices-a-sexual-medicine-society-of-north-america-smsna-member-questionnaire
#6
Michael J Piecuch, Brijesh G Patel, Lawrence Hakim, Run Wang, Hossein Sadeghi-Nejad
INTRODUCTION: There has been renewed interest in the use of subcutaneous testosterone pellets for the treatment of hypogonadism since the introduction of Testopel in 2008 by Slate Pharmaceuticals (Durham, NC, USA). Manufacturer guidelines recommend using two to six pellets; however, in the clinical setting, this is deemed insufficient. This has produced a wide variety of testosterone pellet usage that is not fully understood. AIM: To better understand subcutaneous testosterone pellet implantation practices among members of the Sexual Medicine Society of North America (SMSNA)...
December 15, 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27976414/low-testosterone-alters-the-activity-of-mouse-prostate-stem-cells
#7
Ye Zhou, Ben Copeland, Maya Otto-Duessel, Miaoling He, Susan Markel, Tim W Synold, Jeremy O Jones
BACKGROUND: Low serum testosterone (low T) has been repeatedly linked to worse outcomes in men with newly diagnosed prostate cancer (PC). How low T contributes to these outcomes is unknown. Here we demonstrate that exposure to low T causes significant changes in the mouse prostate and prostate stem cells. METHODS: Mice were castrated and implanted with capsules to achieve castrate, normal, or sub-physiological levels of T. After 6 weeks of treatment, LC-MS/MS was used to quantify the levels of T and dihydrotestosterone (DHT) in serum and prostate tissue...
December 14, 2016: Prostate
https://www.readbyqxmd.com/read/27929275/erectile-dysfunction
#8
Karl T Rew, Joel J Heidelbaugh
Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It is common, affecting at least 12 million U.S. men. The five-question International Index of Erectile Function allows rapid clinical assessment of ED. The condition can be caused by vascular, neurologic, psychological, and hormonal factors. Common conditions related to ED include diabetes mellitus, hypertension, hyperlipidemia, obesity, testosterone deficiency, and prostate cancer treatment...
November 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27888135/antihypertensive-effects-of-androgens-in-conscious-spontaneously-hypertensive-rats
#9
Mercedes Perusquía, Nieves Herrera, Mercedes Ferrer, John N Stallone
Androgens are vasoactive steroids that induce acute vasodilation in a number of isolated vascular beds from different species, but the effects of these hormones on systemic blood pressure (BP) have been studied little. Although it has been reported that androgens exert systemic hypotensive effects through peripheral vasodilation in normotensive rats, there have not been any reports of systemic hypotensive effects of androgens in animals with hypertension. This study was designed to evaluate the acute effects of testosterone (TES) and its 5-reduced metabolites on systemic BP in hypertensive rats and to test the hypothesis that hypotestosteronemia may be involved in the pathogenesis of hypertension...
November 23, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27888061/secretory-function-of-ovarian-cells-and-myometrial-contractions-in-cow-are-affected-by-chlorinated-insecticides-chlordane-heptachlor-mirex-in-vitro
#10
Michael Hubert Wrobel, Jaroslaw Mlynarczuk
The aim of the study was to investigate the effect of chlordane, heptachlor and mirex, on hormonal regulation of the force of myometrial contractions. Myometrial, endometrial, granulosa and luteal cells as well as strips of myometrium from non-pregnant cows were incubated with three insecticides at environmentally relevant doses (0.1, 1 or 10ng/ml). None of the insecticides affected the viability of studied cells. Chlordane stimulated, while heptachlor and mirex inhibited, secretion of testosterone and estradiol from granulosa cells as well as secretion of progesterone from luteal cells, respectively...
January 1, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27884790/altered-spermatogenesis-steroidogenesis-and-suppressed-fertility-in-adult-male-rats-exposed-to-genistein-a-non-steroidal-phytoestrogen-during-embryonic-development
#11
R Meena, Ch Supriya, K Pratap Reddy, P Sreenivasula Reddy
This article focuses on the effects of prenatal exposure to genistein on the mother, her pregnancy and reproductive functions of the male progeny, since these issues have ethological relevance in both animals and humans. Pregnant Wistar rats received i.p. injections of genistein at a dose level of 2, 20 or 100 mg/kg body weight daily from 12(th) to 19(th) day of gestation. Male pups from control and genistein exposed animals were weaned and allowed to develop until 100 days of age; however, when they were 90 days old, twelve males from each group were cohabited with untreated 90-day old females for 8 days...
January 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27872877/data-on-spermatogenesis-in-rat-males-gestationally-exposed-to-bisphenol-a-and-high-fat-diets
#12
Pheruza Tarapore, Max Hennessy, Dan Song, Jun Ying, Bin Ouyang, Vinothini Govindarajah, Yuet-Kin Leung, Shuk-Mei Ho
This data article contains supporting information regarding the research article entitled "High butter-fat diet and bisphenol A additively impair male rat spermatogenesis" (P. Tarapore, M. Hennessy, D. Song, J. Ying, B. Ouyang, V. Govindarajah, et al.,) [1]. Sprague-Dawley females were fed AIN, high fat butter, 17α-ethinyl estradiol, or high fat butter plus four bisphenol A doses (2500 µg/kg bw-d, 250 µg/kg bw-d, 25 µg/kg bw-d, and 2.5 µg/kg bw-d) before and during pregnancy. All diets were switched to AIN after the pups were born...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27817037/effect-of-body-mass-index-on-the-outcomes-of-controlled-ovarian-hyperstimulation-in-chinese-women-with-polycystic-ovary-syndrome-a-multicenter-prospective-observational-study
#13
Yan Sheng, Guangxiu Lu, Jiayin Liu, Xiaoyan Liang, Yanping Ma, Xuehong Zhang, Songying Zhang, Yingpu Sun, Yun Sun, Wenfeng Chen, Wenhui Fang, Zijiang Chen
PURPOSE: The purpose of the present study is to explore the influence of body mass index (BMI) on outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) techniques in Chinese women with polycystic ovary syndrome (PCOS). METHODS: This was a multicenter, prospective, observational study that enrolled 800 subjects with PCOS from nine hospitals in China. Patients were categorized according to BMI categories: underweight, <18.5 kg/m(2); normal, 19-23...
November 5, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27805753/dehydroepiandrosterone-dhea-heightens-aggression-and-increases-androgen-receptor-and-aromatase-mrna-expression-in-the-brain-of-a-male-songbird
#14
Douglas W Wacker, Sahar Khalaj, Lindsey J Jones, Tara L Champion, Jason E Davis, Simone L Meddle, John C Wingfield
Dehydroepiandrosterone, DHEA, is a testosterone/estrogen precursor and known modulator of vertebrate aggression. Male song sparrows (Melospiza melodia morphna) show high aggression during breeding and non-breeding life history stages when circulating DHEA levels are high, and low aggression during molt when DHEA levels are low. We previously showed that androgen receptor and aromatase mRNA expression are higher during breeding and/or non-breeding in brain regions associated with reproductive and aggressive behavior, but DHEA's potential role in mediating these seasonal changes remained unclear...
November 2, 2016: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/27788270/testicular-steroidogenesis-and-locomotor-activity-are-regulated-by-gonadotropin-inhibitory-hormone-in-male-european-sea-bass
#15
José A Paullada-Salmerón, Mairi Cowan, María Aliaga-Guerrero, José F López-Olmeda, Evaristo L Mañanós, Silvia Zanuy, José A Muñoz-Cueto
Gonadotropin-inhibitory hormone (GnIH) is a neurohormone that suppresses reproduction by acting at both the brain and pituitary levels. In addition to the brain, GnIH may also be produced in gonads and can regulate steroidogenesis and gametogenesis. However, the function of GnIH in gonadal physiology has received little attention in fish. The main objective of this study was to evaluate the effects of peripheral sbGnih-1 and sbGnih-2 implants on gonadal development and steroidogenesis during the reproductive cycle of male sea bass (Dicentrarchus labrax)...
2016: PloS One
https://www.readbyqxmd.com/read/27769009/role-of-g-protein-coupled-estrogen-receptor-1-in-estradiol-17%C3%AE-induced-alterations-in-protein-synthesis-and-protein-degradation-rates-in-fused-bovine-satellite-cell-cultures
#16
E Kamanga-Sollo, K J Thornton, M E White, W R Dayton
In feedlot steers, estradiol-17β (E2) and combined E2 and trenbolone acetate (a testosterone analog) implants enhance rate and efficiency of muscle growth; and, consequently, these compounds are widely used as growth promoters in several countries. Treatment with E2 stimulates protein synthesis rate and suppresses protein degradation rate in fused bovine satellite cell (BSC) cultures; however, the mechanisms involved in these effects are not known with certainty. Although the genomic effects of E2 mediated through the classical estrogen receptors have been characterized, recent studies indicate that binding of E2 to the G protein-coupled estrogen receptor (GPER)-1 mediates nongenomic effects of E2 on cellular function...
January 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27764533/signaling-events-associated-with-gonadotropin-releasing-hormone-agonist-induced-hormonal-castration-and-its-reversal-in-canines
#17
Ahmed Bulldan, Mazen Shihan, Sandra Goericke-Pesch, Georgios Scheiner-Bobis
A gonadotropin-releasing hormone agonist (GnRH-A) implant induces hormonal castration in dogs that is associated with reduced prostate and testes size. We address the molecular events associated with hormonal castration by examining GnRH-A effects on expression and phosphorylation of a number of key signaling proteins. Male beagles were treated for 5 months with a GnRH-A implant, and then surgically castrated at 0, 3, 6, 12, and, 24 weeks after implant removal; untreated animals served as controls. GnRH-A treatment led to activation of c-Raf, Erk1/2, and, p53 in the testes...
December 2016: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/27714794/pubertal-pair-housing-facilitates-adult-sexual-behavior-in-male-rats
#18
Heather A Molenda-Figueira, Margaret R Bell, Kayla C De Lorme, Cheryl L Sisk
This study examined the effects of pubertal testosterone (T) and social housing manipulations on male sexual behavior in adult rats. Prepubertal rats were castrated at 21 days of age (P21) and implanted with either blank or T-releasing pellets. At the onset of puberty, P28, half the rats in each treatment group were either single- or pair-housed with a male of the same hormone condition through P56, at which time pellets were removed and all rats were single-housed. In adulthood (P84), all rats received T replacement and were tested for sexual behavior...
January 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/27663363/experimental-elevation-of-wildlife-testosterone-using-silastic-tube-implants
#19
Efrat Koresh, Devorah Matas, Lee Koren
Testosterone (T) is a key androgen that mediates vertebrate molecular, cellular, and behavioral processes. Its manipulation is therefore of interest to a vast number of researchers studying animal behavior and reproduction, among others. Here, the usage of silastic implants across wildlife species is reviewed, and a method to manipulate rock hyrax (Procavia capensis) testosterone levels using silastic implants is presented. Using a series of in-vitro and in-vivo experiments, the secretion patterns of silastic tubes and silastic glue were tested and were surprisingly found to be similar...
October 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27658648/high-butter-fat-diet-and-bisphenol-a-additively-impair-male-rat-spermatogenesis
#20
Pheruza Tarapore, Max Hennessy, Dan Song, Jun Ying, Bin Ouyang, Vinothini Govindarajah, Yuet-Kin Leung, Shuk-Mei Ho
Exposure to xenoestrogens is a probable cause of male infertility in humans. Consumption of high-fat diets and exposure to bisphenol A (BPA) is pervasive in America. Here, we test the hypothesis that gestational exposure to high dietary fats and/or BPA disrupt spermatogenesis in adulthood. Sprague-Dawley rats were fed diets containing 10kcal% butter fat (AIN), 39kcal% butter fat (HFB), or 39kcal% olive oil (HFO), with or without BPA (25μg/kg body weight/day) during pregnancy. One group of male offspring received testosterone (T)- and estradiol-17β (E2)-filled implants or sham-implants from postnatal day (PND)70-210...
September 19, 2016: Reproductive Toxicology
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