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Testosterone implant female

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https://www.readbyqxmd.com/read/28956719/arsenic-trioxide-exposure-impairs-testicular-morphology-in-adult-male-mice-and-consequent-fetus-viability
#1
Raquel Frenedoso da Silva, Cibele Dos Santos Borges, Celina de Almeida Lamas, Valéria Helena Alves Cagnon, Wilma de Grava Kempinas
The acute promyelocytic leukemia (APL) is a rare disease, affecting 0.1/100,000 individuals globally. Despite significant advances in APL therapy, some patients still experience relapsed disease. Currently, arsenic trioxide (As2O3) was found to be effective in relapsed APL treatment and considered as standard treatment for these cases. However, it has been shown that exposure to As2O3 may exert adverse effects on the male reproductive system since this substance might also induce apoptosis of other important cell types including stem cells...
2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28954214/changes-in-plasma-aldosterone-and-electrolytes-levels-kidney-epithelial-sodium-channel-enac-and-blood-pressure-in-normotensive-wky-and-hypertensive-shr-rats-following-gonadectomy-and-chronic-testosterone-treatment
#2
Su Yi Loh, Nelli Giribabu, Naguib Salleh
We hypothesized that testosterone-induced increase in blood pressure involve changes in aldosterone levels and expression of epithelial sodium channel (ENaC) in the kidneys. METHODS: Ovariectomized female normotensive Wistar Kyoto (WKY) and Spontaneous hypertensive (SHR) rats were given six weeks treatment with testosterone via subcutaneous silastic implant. The rats were anesthetized and mean arterial pressure (MAP) was measured via direct cannulation of the carotid artery. Animals were sacrificed and kidneys were removed and subjected for α, β and γ-ENaC protein and mRNA expression analyses by Western blotting and Real-time polymerase chain reaction (qPCR), respectively...
September 24, 2017: Steroids
https://www.readbyqxmd.com/read/28912255/sex-hormones-and-the-development-of-sexual-size-dimorphism-dihydrotestosterone-inhibits-growth-in-a-female-larger-lizard-sceloporus-undulatus
#3
Nicholas B Pollock, Stephanie Feigin, Marko Drazenovic, Henry B John-Alder
Sexual differences in adult body size (sexual size dimorphism; SSD) and color (sexual dichromatism) are widespread, and both male- and female-biased dimorphisms are observed even among closely related species. A growing body of evidence indicates testosterone (T) can regulate growth, thus the development of SSD, and sexual dichromatism. However, the mechanism(s) underlying these effects are conjectural, including possible conversions of T to estradiol (E2) or 5 α-dihydrotestosterone (DHT). In the present study, we hypothesized that effects of T are physiological responses mediated by androgen receptors, and we tested two specific predictions: 1) that DHT would mimic effects of T by inhibiting growth and enhancing coloration, and 2) that removal of endogenous T via surgical castration would stimulate growth...
September 14, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28854721/chronic-combined-hyperandrogenemia-and-western-style-diet-in-young-female-rhesus-macaques-causes-greater-metabolic-impairments-compared-to-either-treatment-alone
#4
C A True, D L Takahashi, S E Burns, E C Mishler, K R Bond, M C Wilcox, A R Calhoun, L A Bader, T A Dean, N D Ryan, O D Slayden, J L Cameron, R L Stouffer
STUDY QUESTION: Does developmental exposure to the combination of hyperandrogenemia and western-style diet (WSD) worsen adult metabolic function compared to either treatment alone? SUMMARY ANSWER: Young female rhesus macaques treated for 3 years, beginning at menarche, with combined testosterone (T) and WSD have increased weight gain and insulin resistance compared to controls and animals treated with either T or WSD alone. WHAT IS KNOWN ALREADY: Hyperandrogenemia is a well-established component of polycystic ovary syndrome (PCOS) and can be observed in peripubertal girls, indicating a potential pubertal onset of the disease...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28854720/combined-androgen-excess-and-western-style-diet-accelerates-adipose-tissue-dysfunction-in-young-adult-female-nonhuman-primates
#5
Oleg Varlamov, Cecily V Bishop, Mithila Handu, Diana Takahashi, Sathya Srinivasan, Ashley White, Charles T Roberts
STUDY QUESTION: What are the separate and combined effects of mild hyperandrogenemia and consumption of a high-fat Western-style diet (WSD) on white adipose tissue (WAT) morphology and function in young adult female nonhuman primates? SUMMARY ANSWER: Combined exposure to mild hyperandrogenemia and WSD induces visceral omental (OM-WAT) but not subcutaneous (SC-WAT) adipocyte hypertrophy that is associated with increased uptake and reduced mobilization of free fatty acids...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28730707/establishment-and-characterization-of-a-novel-murine-model-of-pancreatic-cancer-cachexia
#6
Katherine A Michaelis, Xinxia Zhu, Kevin G Burfeind, Stephanie M Krasnow, Peter R Levasseur, Terry K Morgan, Daniel L Marks
BACKGROUND: Cachexia is a complex metabolic and behavioural syndrome lacking effective therapies. Pancreatic ductal adenocarcinoma (PDAC) is one of the most important conditions associated with cachexia, with >80% of PDAC patients suffering from the condition. To establish the cardinal features of a murine model of PDAC-associated cachexia, we characterized the effects of implanting a pancreatic tumour cell line from a syngeneic C57BL/6 KRAS(G12D) P53(R172H) Pdx-Cre(+/+) (KPC) mouse...
October 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28721614/low-doses-of-chlorpyrifos-interfere-with-spermatogenesis-of-rats-through-reduction-of-sex-hormones
#7
Dinithi Champika Peiris, Thamali Dhanushka
Use of pesticides results in indirect effects on human health. We aimed to evaluate implications of toxicological effects of subchronic chlorpyrifos exposure on reproductive function in male rats. A total of 48 adult Wistar male rats were separated into four groups (n = 12). Animals were gavaged with 2.5 mg/kg (T1), 5 mg/kg (T2), or 10 mg/kg (T3) body weight of chlorpyrifos (CPF) or distilled water (control) daily for 30 days. Organ weights, epididymal sperm parameters, DNA integrity, sex hormonal (FHS and LH) levels, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), and creatinine concentrations were determined on day 31...
July 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28646317/di-n-butyl-phthalate-prompts-interruption-of-spermatogenesis-steroidogenesis-and-fertility-associated-with-increased-testicular-oxidative-stress-in-adult-male-rats
#8
Giribabu Nelli, Sreenivasula Reddy Pamanji
Di-n-butyl phthalate (DBP) is extensively used as plasticizer, and it was ubiquitary released into the environment. The present study was aimed to investigate the effect of DBP on reproductive competence in adult male rats. Adult male rats were received corn oil or DBP injection intraperitoneally (ip) at 100 and 500 mg/kg body weight on 90, 97, 104, and 111 days. Following completion of the experimental period, adult male rats were cohabitated with untreated proestrus female rats for determination of fertilization capacity...
June 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28399644/effects-of-gonadectomy-and-testosterone-treatment-on-aquaporin-expression-in-the-kidney-of-normotensive-and-hypertensive-rats
#9
Su Yi Loh, Nelli Giribabu, Naguib Salleh
We tested the hypothesis that testosterone-induced increase in blood pressure was due to changes in aquaporin (AQP) expression in kidneys. In this study, expression level of kidney AQPs was investigated under testosterone influence. Adult normotensive Wistar Kyoto (WKY) and hypertensive SHR male and female rats underwent gonadectomy. For female rats, testosterone was given for six weeks duration, two weeks following ovariectomy via subcutaneous silastic implant. Mean arterial pressure (MAP) was measured in all the rats after eight weeks via carotid artery cannulation and the rats were then sacrificed and kidneys were harvested for analyses of AQP-1, 2, 3, 4, 6, and 7 mRNA and protein expressions by quantitative real-time PCR and Western blotting, respectively...
July 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28388831/estrogen-signaling-is-necessary-for-exercise-mediated-enhancement-of-motoneuron-participation-in-axon-regeneration-after-peripheral-nerve-injury-in-mice
#10
Melina C Acosta, Patricia A Copley, Jamie R Harrell, Jennifer C Wilhelm
Thousands of people each year suffer from peripheral nerve injury. Treatment options are limited, and recovery is often incomplete. Treadmill exercise can enhance nerve regeneration; however, this appears to occur in a sex-dependent manner. Females respond best to short duration, high speed interval training; whereas, males respond best to slower, continuous training. Previous studies have shown a role for testosterone in this process, but the role of estrogen is unknown. To evaluate the role of estrogen signaling in treadmill exercise, we blocked estrogen receptor (ER) signaling during treadmill exercise in males and female wild type mice...
October 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28160669/effect-of-sex-hormone-levels-sex-body-mass-index-and-other-host-factors-on-human-craniofacial-bone-regeneration-with-bioactive-tricalcium-phosphate-grafts
#11
Christine Knabe, Aynur Mele, Peter Herbert Kann, Barbara Peleska, Doaa Adel-Khattab, Harald Renz, Alexander Reuss, Marc Bohner, Michael Stiller
Little is known regarding the associations between sex-hormone levels, sex, body mass index (BMI), age, other host factors and biomaterial stimulated bone regeneration in the human craniofacial skeleton. The aim of this study was to elucidate the associations between these factors and bone formation after sinus floor augmentation procedures (SFA) utilizing a bioactive tricalcium phosphate (TCP) bone grafting material. We conducted a prospective study in a human population in which 60 male and 60 female participants underwent SFA and dental implant placement using a staged approach...
January 28, 2017: Biomaterials
https://www.readbyqxmd.com/read/28141859/studies-of-hvc-plasticity-in-adult-canaries-reveal-social-effects-and-sex-differences-as-well-as-limitations-of-multiple-markers-available-to-assess-adult-neurogenesis
#12
Olesya T Shevchouk, Gregory F Ball, Charlotte A Cornil, Jacques Balthazart
In songbirds, neurogenesis in the song control nucleus HVC is sensitive to the hormonal and social environment but the dynamics of this process is difficult to assess with a single exogenous marker of new neurons. We simultaneously used three independent markers to investigate HVC neurogenesis in male and female canaries. Males were castrated, implanted with testosterone and housed either alone (M), with a female (M-F) or with another male (M-M) while females were implanted with 17β-estradiol and housed with a male (F-M)...
2017: PloS One
https://www.readbyqxmd.com/read/28135770/testosterone-induced-neuroendocrine-changes-in-the-medial-preoptic-area-precede-song-activation-and-plasticity-in-song-control-nuclei-of-female-canaries
#13
Olesya T Shevchouk, Samar Ghorbanpoor, Gregory F Ball, Charlotte A Cornil, Jacques Balthazart
Testosterone plays a key role in the control of seasonal changes in singing behavior and its underlying neural circuitry. After administration of exogenous testosterone, song quality and song control nuclei volumes change over the course of weeks, but song rate increases within days. The medial preoptic nucleus (POM) controls sexual motivation and testosterone action in POM increases sexually motivated singing. In this study, we investigated the time course of testosterone action in the song control nuclei and POM, at the gross anatomical and cellular level...
April 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28064108/protection-of-male-reproductive-toxicity-in-rats-exposed-to-di-n-butyl-phthalate-during-embryonic-development-by-testosterone
#14
Nelli Giribabu, Pamanji Sreenivasula Reddy
Di-n-butyl phthalate (DBP) widely spread industrial chemical that made drastic alteration in male reproductive system. The present study elucidates the protective role of testosterone on reproductive toxicity in prenatal DBP exposed adult male rats. Pregnant rats were injected with corn oil or 100 and 500mg/kg body weight of DBP on gestation day (GD) 1, 7 and 14. F1 male rats were weaned, injected with either testosterone or vehicle. On postnatal day (PND) 100 F1 adult male rats were cohabited with untreated female rats...
March 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28025851/long-term-effects-of-gnrh-agonists-on-fertility-and-behaviour
#15
REVIEW
S Goericke-Pesch
This review aimed to summarize the present knowledge about the effects of GnRH agonist slow-release implants (GnRH A-SRI) on fertility and behaviour in male and female dogs and cats with special focus on deslorelin. Following an initial stimulation of gonadotropin and testosterone secretion possibly associated with an improved semen quality, GnRH A-SRI induce long-term depression of fertility in male dogs and cats with, however, a large individual variation in onset and duration of efficacy especially in cats...
April 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27884790/altered-spermatogenesis-steroidogenesis-and-suppressed-fertility-in-adult-male-rats-exposed-to-genistein-a-non-steroidal-phytoestrogen-during-embryonic-development
#16
R Meena, Ch Supriya, K Pratap Reddy, P Sreenivasula Reddy
This article focuses on the effects of prenatal exposure to genistein on the mother, her pregnancy and reproductive functions of the male progeny, since these issues have ethological relevance in both animals and humans. Pregnant Wistar rats received i.p. injections of genistein at a dose level of 2, 20 or 100 mg/kg body weight daily from 12(th) to 19(th) day of gestation. Male pups from control and genistein exposed animals were weaned and allowed to develop until 100 days of age; however, when they were 90 days old, twelve males from each group were cohabited with untreated 90-day old females for 8 days...
January 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27872877/data-on-spermatogenesis-in-rat-males-gestationally-exposed-to-bisphenol-a-and-high-fat-diets
#17
Pheruza Tarapore, Max Hennessy, Dan Song, Jun Ying, Bin Ouyang, Vinothini Govindarajah, Yuet-Kin Leung, Shuk-Mei Ho
This data article contains supporting information regarding the research article entitled "High butter-fat diet and bisphenol A additively impair male rat spermatogenesis" (P. Tarapore, M. Hennessy, D. Song, J. Ying, B. Ouyang, V. Govindarajah, et al.,) [1]. Sprague-Dawley females were fed AIN, high fat butter, 17α-ethinyl estradiol, or high fat butter plus four bisphenol A doses (2500 µg/kg bw-d, 250 µg/kg bw-d, 25 µg/kg bw-d, and 2.5 µg/kg bw-d) before and during pregnancy. All diets were switched to AIN after the pups were born...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27368147/aromatized-testosterone-attenuates-contextual-generalization-of-fear-in-male-rats
#18
Joseph F Lynch, Tyler Vanderhoof, Patrick Winiecki, Maeson S Latsko, David C Riccio, Aaron M Jasnow
Generalization is a common symptom of many anxiety disorders, and females are 60% more likely to suffer from an anxiety disorder than males. We have previously demonstrated that female rats display significantly accelerated rates of contextual fear generalization compared to male rats; a process driven, in part, by activation of ERβ. The current study was designed to determine the impact of estrogens on contextual fear generalization in male rats. For experiment 1, adult male rats were gonadectomized (GDX) and implanted with a capsule containing testosterone proprionate, estradiol, dihydrotestosterone proprionate (DHT), or an empty capsule...
August 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27356573/effect-of-copulation-on-potentially-precancerous-prostate-lesions-serum-testosterone-and-prolactin-levels-in-rats
#19
D Herrera-Covarrubias, M B Tecamachaltzi-Silvaran, M Barradas-Moctezuma, J B Rosales-Raya, J Manzo, L I García, G E Aranda-Abreu, N Ismail, G A Coria-Avila, M E Hernández
UNLABELLED: The prostate is an exocrine reproductive gland that participates in ejaculation and it is prone to diseases, including cancer. AIM: In the pre-sent study, we assessed the long-term effects of copulation on the development of precancerous lesions in rats, and compared them with testosterone-induced prostatic lesions. MATERIALS AND METHODS: One group of Wistar males was given 10 copulatory sessions to one ejaculation with ovariectomized, hormone-primed females...
June 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27222598/developmental-programming-postnatal-estradiol-modulation-of-prenatally-organized-reproductive-neuroendocrine-function-in-sheep
#20
Muraly Puttabyatappa, Rodolfo C Cardoso, Carol Herkimer, Almudena Veiga-Lopez, Vasantha Padmanabhan
Gestational testosterone (TS) excess, acting via both the androgenic and estrogenic pathways, advances puberty and disrupts the neuroendocrine estradiol (E2) feedback and periovulatory hormonal dynamics in female sheep. These prenatally programmed defects may be subject to postnatal modifications by continued organizational and/or activational effects of steroids. This study investigated (1) the organizational contribution of prenatal estrogen excess and (2) the impact of postnatal exposure to E2 in modulating the effects of prenatal androgen excess (TS and dihydrotestosterone (DHT)) on puberty, neuroendocrine feedback mechanisms, and periovulatory hormonal dynamics in sheep...
August 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
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