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Mariana Angélica Peixoto de Souza, Jane Fonseca Dias, Fabiane Ribeiro Ferreira, Marisa Cotta Mancini, Renata Noce Kirkwood, Rosana Ferreira Sampaio
The cross sectional study aims to create the patients' profile and understand their demands for seeking public rehabilitation services from Belo Horizonte. Data were analyzed from 516 patients who gained entry into the health care system by means of the Protocol for Identification of Problems for Rehabilitation (PLPR). It allows for gathering information related to one's health and the social context, including a brief functional description (BFD) with 25 items. Most patients were females, mean age of 57 years, and 54% declared to be responsible for the family income...
October 2016: Ciência & Saúde Coletiva
Fabian Gottwald, Matteo Bonfanti, Rocco Martinazzo, Sergei D Ivanov, Oliver Kühn
No abstract text is available yet for this article.
September 28, 2016: Journal of Chemical Physics
Fabian Dielmann, Eugenia V Peresypkina, Barbara Krämer, Florian Hastreiter, Brian P Johnson, Manfred Zabel, Claudia Heindl, Manfred Scheer
The cyclo-P4 complexes [Cp(R) Ta(CO)2 (η(4) -P4 )] (Cp(R) : Cp''=1,3-C5 H3 tBu2 , Cp'''=1,2,4-C5 H2 tBu3 ) turned out to be predestined for the formation of hollow spherical supramolecules with non-classical fullerene-like topology. The resulting assemblies constructed with CuX (X=Cl, Br) showed a highly symmetric 32-vertex core of solely four- and six-membered rings. In some supramolecules, the inner cavity was occupied by an additional CuX unit. On the other hand, using CuI, two different supramolecules with either peanut- or pear-like shapes and outer diameters in the range of 2-2...
October 26, 2016: Angewandte Chemie
Tatiana Ermakova, Benjamin Fabian, Rüdiger Zarnekow
BACKGROUND: Cloud computing promises to essentially improve healthcare delivery performance. However, shifting sensitive medical records to third-party cloud providers could create an adoption hurdle because of security and privacy concerns. OBJECTIVES: This study examines the effect of confidentiality assurance in a cloud-computing environment on individuals' willingness to accept the infrastructure for inter-organizational sharing of medical data. METHODS: We empirically investigate our research question by a survey with over 260 full responses...
October 26, 2016: Applied Clinical Informatics
Fabian Depré, Nasra Aboud, Frauke Ringel, Abdulgabar Salama
BACKGROUND: Eltrombopag and romiplostim are thrombopoietin receptor agonists (TPOs) that have been increasingly used for the treatment of immune thrombocytopenia (ITP). Based on our experience, the incidence of abortive treatment with these drugs and the occurrence of adverse reactions that lead to therapy break-off despite response are higher than has been previously suggested. METHODS: During the last 8 years, a total of 65 patients were treated with eltrombopag and/or romiplostim at our institute...
September 2016: Transfusion Medicine and Hemotherapy
Max Schelker, Caroline Maria Mair, Fabian Jolmes, Robert-William Welke, Edda Klipp, Andreas Herrmann, Max Flöttmann, Christian Sieben
After endocytic uptake, influenza viruses transit early endosomal compartments and eventually reach late endosomes. There, the viral glycoprotein hemagglutinin (HA) triggers fusion between endosomal and viral membrane, a critical step that leads to release of the viral segmented genome destined to reach the cell nucleus. Endosomal maturation is a complex process involving acidification of the endosomal lumen as well as endosome motility along microtubules. While the pH drop is clearly critical for the conformational change and membrane fusion activity of HA, the effect of intracellular transport dynamics on the progress of infection remains largely unclear...
October 2016: PLoS Computational Biology
Christophe von Garnier, Fabian Blank, Barbara Rothen-Rutishauser, Joachim R Goethert, Patrick G Holt, Philip A Stumbles, Deborah H Strickland
The pulmonary parenchymal and mucosal microenvironments are constantly exposed to the external environment and thus require continuous surveillance to maintain steady-state immunological homeostasis. This is achieved by a mobile network of pulmonary dendritic cells (DC) and macrophages (mø) that constantly sample and process microenvironmental antigens into signals that can initiate or dampen inflammation, either locally or after onward migration to draining lymph nodes. The constant steady-state turnover of pulmonary DC and mø requires replenishment from bone-marrow precursors, however the nature of the pulmonary precursor cell remains unclear, although recent studies suggest that subsets of pulmonary DC may derive from circulating monocytic precursors...
October 25, 2016: American Journal of Respiratory Cell and Molecular Biology
C Patrick Shahan, Louis J Magnotti, Timothy C Fabian
No abstract text is available yet for this article.
October 25, 2016: Journal of Trauma and Acute Care Surgery
Silin Sa, Mingxia Gu, James Chappell, Ning-Yi Shao, Mohamed Ameen, Kathryn A T Elliott, Dan Li, Fabian Grubert, Caiyun G Li, Shalina Taylor, Aiqin Cao, Yu Ma, Ryan Fong, Long Nguyen, Joseph C Wu, Michael P Snyder, Marlene Rabinovitch
RATIONALE: Idiopathic or heritable pulmonary arterial hypertension is characterized by loss and obliteration of lung vasculature. Endothelial cell dysfunction is pivotal to the pathophysiology but different causal mechanisms may reflect a need for patient-tailored therapies. OBJECTIVES: Endothelial cells differentiated from induced pluripotent stem cells were compared to pulmonary arterial endothelial cells from the same patients with idiopathic or heritable pulmonary arterial hypertension, to determine whether they shared functional abnormalities and altered gene expression patterns, that differed from those in unused donor cells...
October 25, 2016: American Journal of Respiratory and Critical Care Medicine
Joseph J Ryan, David S Kreiner, Laura Glass Umfleet, Samuel T Gontkovsky, Allison Myers-Fabian
We examined relationships between the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) General Ability Index (GAI) and Cognitive Proficiency Index (CPI) in two clinical samples. The mean pattern produced by 42 individuals with multiple sclerosis (MS) and 47 with traumatic brain injury (TBI) was the same, GAI > CPI. This pattern occurred in 61.9% and 78.7% of the protocols of patients with MS or TBI, respectively. The MS sample earned a significantly larger CPI mean than did patients with TBI...
October 25, 2016: Applied Neuropsychology. Adult
Paul Mehlmann, Christian Mück-Lichtenfeld, Tristan T Y Tan, Fabian Dielmann
We report the synthesis and remarkable properties of phosphine P(NIiPr)3 (NIiPr = 1,3-diisopropyl-4,5-dimethylimidazolin-2-ylidenamino), a crystalline solid accessible through a short and scalable route. Evaluation of the electron donor properties reveals a TEP value of 2029.7 cm-1 for the new phosphine that is significantly lower than those of all known phosphines or even N-heterocyclic carbenes. Moreover, P(NIiPr)3 is more basic [pKBH+(MeCN) = 38.8] than Verkade's proazaphosphatranes, thus being the strongest reported nonionic phosphorus(III) superbase...
October 25, 2016: Chemistry: a European Journal
Eva Schrezenmeier, Kayin Wu, Fabian Halleck, Lutz Liefeldt, Susanne Brakemeier, Friederike Bachmann, Susanne Kron, Klemens Budde, Michael Duerr
Recurrence of hepatitis C virus (HCV)-associated membranoproliferative glomerulonephritis (MPGN) in the kidney transplant may lead to continuous graft deterioration and the need for further renal replacement therapy. The novel direct acting antiviral agents (DAAs) allow a highly effective and interferon-free treatment option for chronic HCV infected patients. Data on the therapeutic safety and efficacy in HCV infected renal transplant patients are sparse, especially for patients with severe renal impairment...
October 25, 2016: American Journal of Transplantation
Fabián Méndez, Lyda Osorio
No abstract text is available yet for this article.
October 24, 2016: International Journal of Public Health
Marc Dewey, Matthias Rief, Peter Martus, Benjamin Kendziora, Sarah Feger, Henryk Dreger, Sascha Priem, Fabian Knebel, Marko Böhm, Peter Schlattmann, Bernd Hamm, Eva Schönenberger, Michael Laule, Elke Zimmermann
OBJECTIVE:  To evaluate whether invasive coronary angiography or computed tomography (CT) should be performed in patients clinically referred for coronary angiography with an intermediate probability of coronary artery disease. DESIGN:  Prospective randomised single centre trial. SETTING:  University hospital in Germany. PARTICIPANTS:  340 patients with suspected coronary artery disease and a clinical indication for coronary angiography on the basis of atypical angina or chest pain...
October 24, 2016: BMJ: British Medical Journal
Fabian Sanchis-Gomar, Carme Perez-Quilis, Giuseppe Lippi, Gianfranco Cervellin, Roman Leischik, Herbert Löllgen, Enrique Serrano-Ostáriz, Alejandro Lucia
Atrial fibrillation (AF) is the most common heart arrhythmia, the risk of which typically increases with age. This condition is commonly associated with major cardiovascular diseases and structural heart damage, while it is rarely observed in healthy young people. However, increasing evidence indicates that paroxysmal AF can also onset in young or middle-aged and otherwise healthy endurance athletes (e.g., cyclists, runners and cross-country skiers). Here we review the topic of AF associated with strenuous endurance exercise (SEE), for example cycling, running and cross-country skiing, especially at a competitive level, and we propose the definition of a new syndrome based on the accumulating data in the literature: SEE-related AF under the acronym of 'PAFIYAMA' ('paroxysmal AF in young and middle-aged athletes')...
October 19, 2016: International Journal of Cardiology
Carlos Sanhueza, Joaquín Araos, Luciano Naranjo, Fernando Toledo, Ana R Beltrán, Marco A Ramírez, Jaime Gutiérrez, Fabián Pardo, Andrea Leiva, Luis Sobrevia
Cancer cells generate protons (H(+)) that are extruded to the extracellular medium mainly via the Na(+)/H(+) exchanger 1 (NHE1), which regulates intracellular pH (pHi) and cell proliferation. In primary cultures of human ascites-derived ovarian cancer cells (haOC) we assayed whether NHE1 was required for pHi modulation and cell proliferation. Human ovary expresses NHE1, which is higher in haOC and A2780 (ovarian cancer cells) compared with HOSE cells (normal ovarian cells). Basal pHi and pHi recovery (following a NH4Cl pulse) was higher in haOC and A2780, compared with HOSE cells...
October 21, 2016: Biochimica et Biophysica Acta
Leopold Zangemeister, Fabian Grabenhorst, Wolfram Schultz
Economic saving is an elaborate behavior in which the goal of a reward in the future directs planning and decision-making in the present. Here, we measured neural activity while subjects formed simple economic saving strategies to accumulate rewards and then executed their strategies through choice sequences of self-defined lengths. Before the initiation of a choice sequence, prospective activations in the amygdala predicted subjects' internal saving plans and their value up to two minutes before a saving goal was achieved...
October 19, 2016: Current Biology: CB
J M Dyke, G A Cadden, V A Fabian
No abstract text is available yet for this article.
February 2016: Pathology
J M Dyke, D M Moss, V A Fabian
No abstract text is available yet for this article.
February 2016: Pathology
J M Dyke, R C Junckerstoff, V A Fabian
No abstract text is available yet for this article.
February 2016: Pathology
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