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https://www.readbyqxmd.com/read/28329082/aortic-elongation-and-the-risk-for-dissection-the-t%C3%A3-bingen-aortic-pathoanatomy-taipan-project%C3%A2
#1
Tobias Krüger, Alexandre Oikonomou, David Schibilsky, Mario Lescan, Katharina Bregel, Luise Vöhringer, Wilke Schneider, Henning Lausberg, Gunnar Blumenstock, Fabian Bamberg, Christian Schlensak
OBJECTIVES: We measured aortic dimensions, particularly length parameters, using 3D imaging with the aim of refining the risk-morphology for Stanford type A aortic dissection (TAD). METHODS: Computer tomography angiography studies were analysed using the curved multiplanar reformats. At defined landmarks, the diameters and lengths of aortic segments were recorded. Three groups were compared retrospectively: patients actually suffering from a TAD (TAD-group; n  = 150), patients before suffering a TAD (preTAD-group n  = 15) and a healthy control group ( n  = 215)...
February 16, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28328527/on-the-conditional-power-in-survival-time-analysis-considering-cure-fractions
#2
Andreas Kuehnapfel, Fabian Schwarzenberger, Markus Scholz
Conditional power of survival endpoints at interim analyses can support decisions on continuing a trial or stopping it for futility. When a cure fraction becomes apparent, conditional power cannot be calculated accurately using simple survival models, e.g. the exponential model. Non-mixture models consider such cure fractions. In this paper, we derive conditional power functions for non-mixture models, namely the non-mixture exponential, the non-mixture Weibull, and the non-mixture Gamma models. Formulae were implemented in the R package CP...
March 17, 2017: International Journal of Biostatistics
https://www.readbyqxmd.com/read/28328224/site-controlled-growth-of-monolithic-ingaas-inp-quantum-well-nanopillar-lasers-on-silicon
#3
Fabian Schuster, Jonas Kapraun, Gilliard N Malheiros-Silveira, Saniya Deshpande, Connie J Chang-Hasnain
In this letter, we report the site-controlled growth of InP nanolasers on a silicon substrate with patterned SiO2 nanomasks by low-temperature metalorganic chemical vapor deposition, compatible with silicon CMOS postprocessing. A two-step growth procedure is presented to achieve smooth wurtzite faceting of vertical nanopillars. By incorporating InGaAs multi-quantum-wells, the nanopillar emission can be tuned over a wide spectral range. Enhanced quality factors of the intrinsic InP nanopillar cavities promote lasing at 0...
March 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/28328191/enhancing-tumor-penetration-of-nanomedicines
#4
Qingxue Sun, Tarun Ojha, Fabian Kiessling, Twan Lammers, Yang Shi
Tumor-targeted nanomedicines have been extensively applied to alter the drawbacks and enhance the efficacy of chemotherapeutics. Despite the large number of preclinical nanomedicine studies showing initial success, their therapeutic benefit in the clinic has been rather modest, which is partially due to the inefficient tumor penetration caused by tumor microenvironment (high density of cells and extracellular matrix, increased interstitial fluid pressure). Furthermore, tumor penetration of nanomedicines is significantly influenced by physicochemical characteristics such as size, surface chemistry and shape...
March 22, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28327693/single-versus-two-visits-with-1-week-intracanal-calcium-hydroxide-medication-for-endodontic-treatment-one-year-post-treatment-results-from-a-multicentre-randomised-controlled-trial
#5
Federica Fonzar, Aniello Mollo, Mauro Venturi, Pierpaolo Pini, Riccardo Fabian Fonzar, Anna Trullenque-Eriksson, Marco Esposito
PURPOSE: To evaluate whether it is more effective to complete endodontic treatment in a single visit or in two visits with 1-week intracanal calcium hydroxide medication in symptomatic teeth and teeth with periapical lesions. MATERIALS AND METHODS: One hundred and ninety-nine patients, with one symptomatic tooth or a tooth with a periapical lesion, were randomised, according to a parallel group design, to receive a complete endodontic treatment in a single visit (99 patients) or in two visits with 1-week intracanal calcium hydroxide medication (100 patients), at two centres...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28326672/bk-polyomavirus-specific-9mer-cd8-t-cell-responses-correlate-with-clearance-of-bk-viremia-in-kidney-transplant-recipients-first-report-from-the-swiss-transplant-cohort-study-stcs
#6
Céline Leboeuf, Sabrina Wilk, Rita Achermann, Isabelle Binet, Dela Golshayan, Karin Hadaya, Cedric Hirzel, Matthias Hoffmann, Uyen Huynh-Do, Michael T Koller, Oriol Manuel, Nicolas J Mueller, Thomas F Mueller, Stefan Schaub, Christian van Delden, Fabian H Weissbach, Hans H Hirsch
BK polyomavirus (BKPyV) causes premature kidney transplant (KT) failure in 1-15% of patients. Since antivirals are lacking, most programs screen for BKPyV-viremia and, if positive, reduce immunosuppression. To evaluate the relationship of viremia and BKPyV-specific immunity, we examined prospectively cryopreserved plasma and PBMCs at T0, T6, and T12 months post-transplant from 28 viremic KT patients and 68 non-viremic controls matched for the transplantation period. BKPyV-IgG seroprevalence was comparable between cases (89...
March 22, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28325058/-mixed-adenoneuroendocrine-carcinoma-manec-of-the-gastrointestinal-tract
#7
R Šefr, L Němec, P Fabian, L Fiala
Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumour of the gastrointestinal tract composed of adenocarcinoma and neuroendocrine carcinoma. This pathologic diagnosis was recently defined by the WHO in 2010. The tumour may appear in various levels of the digestive tract including the oesophagus, stomach, colon and appendix. Biological behaviour of MANEC seems to be quite unpredictable and the prognosis uncertain. The disease may also mimic "simple" carcinoma. Only several tens of cases have been reported so far...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28320364/the-weight-of-pupils-schoolbags-in-early-school-age-and-its-influence-on-body-posture
#8
Anna Brzęk, Tarja Dworrak, Markus Strauss, Fabian Sanchis-Gomar, Ibtissam Sabbah, Birgit Dworrak, Roman Leischik
BACKGROUND: Postural development progresses through a series of stages (growth spurts, development of balance and coordination, postural stability) which occur when children are at school age. The reduction in the level of physical activity, increased body weight, overloaded school bags, asymmetry of the backpack straps, the method of putting on and taking off the backpacks and increased usage of electronic devices have negative side effects such as bad body posture habits. METHODS: A prospective cohort study in the group of 155 pupils at early school age 7-9 years old has been conducted...
March 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28318332/abnormality-of-adipokines-and-endothelial-dysfunction-in-mexican-obese-adolescents-with-insulin-resistance
#9
Maria Del Carmen Ortiz Segura, Blanca Estela Del Río Navarro, Benjamín Antonio Rodríguez Espino, Laurence A Marchat, Fausto Sánchez Muñoz, Santiago Villafaña, Enrique Hong, Fabián Meza-Cuenca, Patrick Mailloux Salinas, Francisco Bolaños-Jiménez, Elena Zambrano, Abel Armando Arredondo-López, Guadalupe Bravo, Fengyang Huang
PURPOSE: The aim of this study was to investigate the possible relationship among insulin resistance (IR), endothelial dysfunction, and alteration of adipokines in Mexican obese adolescents and their association with metabolic syndrome (MetS). MATERIALS AND METHODS: Two hundred and twenty-seven adolescents were classified according to the body mass index (BMI) (control: N=104; obese: N=123) and homeostasis model of the assessment-insulin resistance index (HOMA-IR) (obese with IR: N=65)...
March 20, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28317274/quality-of-warfarin-therapy-and-risk-of-stroke-bleeding-and-mortality-among-patients-with-atrial-fibrillation-results-from-the-nationwide-finwaf-registry
#10
Mika Lehto, Jussi Niiranen, Pasi Korhonen, Juha Mehtälä, Houssem Khanfir, Fabian Hoti, Riitta Lassila, Pekka Raatikainen
PURPOSE: The most important management strategy in atrial fibrillation (AF) patients is preventing stroke with oral anticoagulants. Warfarin is still used as a first-line anticoagulant, although non-vitamin K antagonist oral anticoagulants are currently recommended to manage AF. Using a large, unselected national sample of AF patients, we evaluated the relationships between quality of warfarin therapy and the risks of thromboembolism, bleeding complications, and mortality. METHODS: The nationwide FinWAF study included 54 568 AF patients taking warfarin...
March 19, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28317111/an-experimental-test-of-the-habitat-amount-hypothesis-for-saproxylic-beetles-in-a-forested-region
#11
Sebastian Seibold, Claus Bässler, Roland Brandl, Lenore Fahrig, Bernhard Förster, Marco Heurich, Torsten Hothorn, Fabian Scheipl, Simon Thorn, Jörg Müller
The habitat-amount hypothesis challenges traditional concepts that explain species richness within habitats, such as the habitat-patch hypothesis, where species number is a function of patch size and patch isolation. It posits that effects of patch size and patch isolation are driven by effects of sample area, and thus that the number of species at a site is basically a function of the total habitat amount surrounding this site. We tested the habitat-amount hypothesis for saproxylic beetles and their habitat of dead wood by using an experiment comprising 190 plots with manipulated patch sizes situated in a forested region with a high variation in habitat amount (i...
March 19, 2017: Ecology
https://www.readbyqxmd.com/read/28316937/metastasectomy-of-abdominal-wall-lesions-due-to-prostate-cancer-detected-through-pet-ct-gallium-68-pmsa-first-case-report
#12
Claudia Ochoa, Angie Ramirez, Rodolfo Varela, Fabian Godoy, Rafael Vargas, Jorge Forero, Andres Rojas, Carmen Roa, Carlos Céspedes, Jose Ramos, Marino Cabrera, Andres Calderon
Introducing the topic of abdominal wall metastasis secondary to prostate cancer with a reminder of the disease's rarity, being the first published case. This article is about a 66 year old patient diagnosed with prostate cancer [cT2aNxMx iPSA: 5,6 ng/ml Gleason 3+3, (Grade 1 Group)], treated with radical prostatectomy as well as accompanied with amplified pelvic lymphadenectomy, who subsequently presented metastatic lesions to the abdominal wall diagnosed with PET/CT Gallium 68-PMSA technique and treated with abdominal metastasectomy with adequate short term results...
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28316752/determinants-of-wealth-fluctuation-changes-in-hard-to-measure-economic-variables-in-a-panel-study
#13
Fabian T Pfeffer, Jamie Griffin
Measuring fluctuation in families' economic conditions is the raison d'être of household panel studies. Accordingly, a particularly challenging critique is that extreme fluctuation in measured economic characteristics might indicate compounding measurement error rather than actual changes in families' economic wellbeing. In this article, we address this claim by moving beyond the assumption that particularly large fluctuation in economic conditions might be too large to be realistic. Instead, we examine predictors of large fluctuation, capturing sources related to actual socio-economic changes as well as potential sources of measurement error...
2017: Methoden, Daten, Analysen
https://www.readbyqxmd.com/read/28316621/impact-of-pressurized-intraperitoneal-aerosol-chemotherapy-on-quality-of-life-and-symptoms-in-patients-with-peritoneal-carcinomatosis-a-retrospective-cohort-study
#14
Hugo Teixeira Farinha, Fabian Grass, Amaniel Kefleyesus, Chahin Achtari, Benoit Romain, Michael Montemurro, Nicolas Demartines, Martin Hübner
Background. Peritoneal cancer treatment aims to prolong survival, but preserving Quality of Life (QoL) under treatment is also a priority. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a novel minimally invasive repeatable treatment modality. The aim of the present study was to assess QoL in our cohort of PIPAC patients. Methods. Analysis of all consecutive patients included from the start of PIPAC program (January 2015). QoL (0-100: optimal) and symptoms (no symptom: 0-100) were measured prospectively before and after every PIPAC procedure using EORTC QLQ-C30...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28316234/modeling-exposure-in-the-tox21-in-vitro-bioassays
#15
Fabian Christoph Fischer, Luise Henneberger, Maria König, Kai Bittermann, Lukas Linden, Kai-Uwe Goss, Beate I Escher
High-throughput in vitro bioassays are becoming increasingly important in the risk characterization of anthropogenic chemicals. Large databases gather nominal effect concentrations (Cnom) for diverse modes of action. However, the biologically effective concentration can substantially deviate due to differences in chemical partitioning. In this study, we modeled freely dissolved (Cfree), cellular (Ccell), and membrane concentrations (Cmem) in the Tox21 GeneBLAzer bioassays for a set of neutral and ionogenic organic chemicals covering a large physicochemical space...
March 19, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28316106/chironomus-riparius-diptera-genome-sequencing-reveals-the-impact-of-minisatellite-transposable-elements-on-population-divergence
#16
Ann-Marie Oppold, Hanno Schmidt, Marcel Rose, Sören Lukas Hellmann, Florian Dolze, Fabian Ripp, Bettina Weich, Urs Schmidt-Ott, Erwin Schmidt, Robert Kofler, Thomas Hankeln, Markus Pfenninger
Active transposable elements (TEs) may result in divergent genomic insertion and abundance patterns among conspecific populations. Upon secondary contact, such divergent genetic backgrounds can theoretically give rise to classical Dobzhansky-Muller incompatibilities (DMI), thus contributing to the evolution of endogenous genetic barriers and eventually cause population divergence. We investigated differential TE abundance among conspecific populations of the non-biting midge Chironomus riparius and evaluated their potential role in causing endogenous genetic incompatibilities between these populations...
March 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28315666/feasibility-and-safety-of-a-powered-exoskeleton-for-assisted-walking-for-persons-with-multiple-sclerosis-a-single-group-preliminary-study
#17
Allan J Kozlowski, Michelle Fabian, Dipan Lad, Andrew Delgado
OBJECTIVE: To examine the feasibility, safety, and secondary benefit potential of exoskeleton-assisted walking with one device for persons with multiple sclerosis (MS) DESIGN: Single-group longitudinal preliminary study with 8-week baseline, 8-week intervention, and 4-week follow-up. SETTING: Outpatient MS clinic at tertiary care hospital. PARTICIPANTS: The 13 participants were mostly female who ranged in age from 38-62 years and on Expanded Disability Status Scale scores from 5...
March 15, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28314210/options-and-limitations-for-bromate-control-during-ozonation-of-wastewater
#18
Fabian Soltermann, Christian Abegglen, Manfred Tschui, Sandro Stahel, Urs von Gunten
Wastewater treatment plants (WWTPs) are important point sources for micropollutants, which are harmful to freshwater organisms. Ozonation of wastewater is a powerful option to abate micropollutants, but may result in the formation of the potentially toxic oxidation by-product bromate in bromide-containing wastewaters. This study investigates options to reduce bromate formation during wastewater ozonation by (i) reducing the bromide concentration of the wastewater, (ii) lowering the ozone dose during wastewater treatment and (iii) adding hydrogen peroxide to limit the lifetime of ozone and quench the intermediates of the bromate formation pathway...
February 14, 2017: Water Research
https://www.readbyqxmd.com/read/28302527/multiple-plastic-stents-versus-covered-metal-stent-for-treatment-of-anastomotic-biliary-strictures-after-liver-transplantation-a-prospective-randomized-multicenter-trial
#19
Andrea Oliver Tal, Fabian Finkelmeier, Natalie Filmann, Leena Kylänpää, Marianne Udd, Ilaria Parzanese, Paolo Cantù, Alexander Dechêne, Volker Penndorf, Andreas Schnitzbauer, Mireen Friedrich-Rust, Stefan Zeuzem, Jörg G Albert
BACKGROUND AND AIMS: Treatment of anastomotic biliary strictures (ABSs) after orthotopic liver transplantation (OLT) by endoscopic insertion of multiple plastic stents (MPSs) is well-established. The use of covered self-expandable metal stents (cSEMSs) for this indication is less investigated. METHODS: In an open-label, multicenter, randomized trial, patients with confirmed ABSs were randomly assigned 1:1 to receive either an MPS or a cSEMS. Primary endpoint was the number of endoscopic interventions until ABS resolution...
March 13, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28302322/high-risk-histopathology-features-in-primary-and-secondary-enucleated-international-intraocular-retinoblastoma-classification-group-d-eyes
#20
Ido D Fabian, Andrew W Stacey, Tanzina Chowdhury, Catriona Duncan, Esin K Karaa, Irene Scheimberg, M Ashwin Reddy, Mandeep S Sagoo
PURPOSE: To evaluate the rate and identify the risk factors for high-risk histopathologic features in group D retinoblastoma eyes enucleated as primary or secondary treatment. DESIGN: Retrospective analysis. PARTICIPANTS: A total of 64 enucleated group D eyes (62 patients), of which 40 (40 patients) were primary and 24 (22 patients) were secondary to other treatments. METHODS: Clinicopathologic correlation of consecutive group D eyes enucleated from 2002 to 2014...
March 13, 2017: Ophthalmology
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