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https://www.readbyqxmd.com/read/29166617/spatiotemporal-proteomic-profiling-of-huntington-s-disease-inclusions-reveals-widespread-loss-of-protein-function
#1
Fabian Hosp, Sara Gutiérrez-Ángel, Martin H Schaefer, Jürgen Cox, Felix Meissner, Mark S Hipp, F-Ulrich Hartl, Rüdiger Klein, Irina Dudanova, Matthias Mann
Aggregation of polyglutamine-expanded huntingtin exon 1 (HttEx1) in Huntington's disease (HD) proceeds from soluble oligomers to late-stage inclusions. The nature of the aggregates and how they lead to neuronal dysfunction is not well understood. We employed mass spectrometry (MS)-based quantitative proteomics to dissect spatiotemporal mechanisms of neurodegeneration using the R6/2 mouse model of HD. Extensive remodeling of the soluble brain proteome correlated with insoluble aggregate formation during disease progression...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166445/regular-access-and-adherence-to-medications-of-the-specialized-component-of-pharmaceutical-services
#2
Janaína Soder Fritzen, Fabiane Raquel Motter, Vera Maria Vieira Paniz
OBJECTIVE: To investigate the prevalence of the adherence to the medications of the Specialized Component of Pharmaceutical Services and its association with regular access in users of these medications in the municipality of São Leopoldo, State of Rio Grande do Sul, Brazil. METHODS: This is a cross-sectional study with adults aged 20 years and over, who are users of medications of the Specialized Component of Pharmaceutical Services. Sampling was carried out consecutively for users who accessed the service of the Specialized Component of Pharmaceutical Services during the period from December 2014 to March 2015...
2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29165733/impact-of-type-of-sport-gender-and-age-on-red-blood-cell-deformability-of-elite-athletes
#3
Fabian Tomschi, Wilhelm Bloch, Marijke Grau
Our objective was to detect possible differences in red blood cell (RBC) deformability of elite athletes performing different types of sports and being of different age and gender.182 athletes were included in this cross-sectional study. RBC deformability was measured using the laser-assisted optical rotational cell-analyzer. Maximal elongation index (EI max) and shear stress at half-maximum deformation (SS 1/2) were calculated. The ratio SS 1/2 /EI max (EI Ratio) was calculated with low values representing high RBC deformation...
November 17, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29164318/clinical-pathological-conference-series-from-the-medical-university-of-graz-case-no-153-a%C3%A2-55-year-old-woman-with-atypical-multiple-sclerosis-and-irritable-bowel-syndrome
#4
Elisabeth Fabian, Dietmar Schiller, Hermann Toplak, Michaela Brunner-Krainz, Franz Fazekas, Rainer Schoefl, Guenter J Krejs
No abstract text is available yet for this article.
November 21, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29163636/a-pipeline-for-high-throughput-concentration-response-modeling-of-gene-expression-for-toxicogenomics
#5
John S House, Fabian A Grimm, Dereje D Jima, Yi-Hui Zhou, Ivan Rusyn, Fred A Wright
Cell-based assays are an attractive option to measure gene expression response to exposure, but the cost of whole-transcriptome RNA sequencing has been a barrier to the use of gene expression profiling for in vitro toxicity screening. In addition, standard RNA sequencing adds variability due to variable transcript length and amplification. Targeted probe-sequencing technologies such as TempO-Seq, with transcriptomic representation that can vary from hundreds of genes to the entire transcriptome, may reduce some components of variation...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29163620/an-oleuropein-%C3%AE-glucosidase-from-olive-fruit-is-involved-in-determining-the-phenolic-composition-of-virgin-olive-oil
#6
David Velázquez-Palmero, Carmen Romero-Segura, Rosa García-Rodríguez, María L Hernández, Fabián E Vaistij, Ian A Graham, Ana G Pérez, José M Martínez-Rivas
Phenolic composition of virgin olive oil is determined by the enzymatic and/or chemical reactions that take place during olive fruit processing. Of these enzymes, β-glucosidase activity plays a relevant role in the transformation of the phenolic glycosides present in the olive fruit, generating different secoiridoid derivatives. The main goal of the present study was to characterize olive fruit β-glucosidase genes and enzymes responsible for the phenolic composition of virgin olive oil. To achieve that, we have isolated an olive β-glucosidase gene from cultivar Picual (OepGLU), expressed in Nicotiana benthamiana leaves and purified its corresponding recombinant enzyme...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29161595/a-coincidence-detection-mechanism-controls-px-bar-domain-mediated-endocytic-membrane-remodeling-via-an-allosteric-structural-switch
#7
Wen-Ting Lo, Andreja Vujičić Žagar, Fabian Gerth, Martin Lehmann, Dymtro Puchkov, Oxana Krylova, Christian Freund, Leonardo Scapozza, Oscar Vadas, Volker Haucke
Clathrin-mediated endocytosis occurs by bending and remodeling of the membrane underneath the coat. Bin-amphiphysin-rvs (BAR) domain proteins are crucial for endocytic membrane remodeling, but how their activity is spatiotemporally controlled is largely unknown. We demonstrate that the membrane remodeling activity of sorting nexin 9 (SNX9), a late-acting endocytic PX-BAR domain protein required for constriction of U-shaped endocytic intermediates, is controlled by an allosteric structural switch involving coincident detection of the clathrin adaptor AP2 and phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2) at endocytic sites...
November 20, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29161478/-spatial-distribution-of-potential-and-positive-aedes-aegypti-breeding-sites
#8
Daniel Elías Cuartas, Genny Martínez, Diana María Caicedo, Jhonny Garcés, Yoseth Ariza-Araujo, Miguel Peña, Fabián Mendéz
INTRODUCTION: The spatial distribution of Aedes aegypti is heterogeneous, and the interaction between positive and potential breeding sites located both inside and outside homes is one of the most difficult aspects to characterize in vector control programs. OBJECTIVE: To describe the spatial relationship between potential and positive breeding sites of A. aegypti inside and outside homes in Cali, Colombia. MATERIALS AND METHODS: We conducted an entomological survey to collect data from both indoor and outdoor breeding sites...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29159617/-medical-aid-at-sea
#9
REVIEW
Fabian Steffen, Philipp Stalling
No abstract text is available yet for this article.
November 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/29159286/tailor-made-temperature-dependent-thermal-conductivity-via-interparticle-constriction
#10
Fabian A Nutz, Markus Retsch
Managing heat is a major challenge to meet future demands for a sustainable use of our energy resources. This requires materials, which can be custom-designed to exhibit specific temperature-dependent thermal transport properties to become integrated into thermal switches, transistors, or diodes. Common crystalline and amorphous materials are not suitable, owing to their gradual changes of the temperature-dependent thermal conductivity. We show how a second-order phase transition fully controls the temperature-dependent thermal transport properties of polymer materials...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29159237/motion-database-of-disguised-and-non-disguised-team-handball-penalty-throws-by-novice-and-expert-performers
#11
Fabian Helm, Nikolaus F Troje, Jörn Munzert
This article describes the motion database for a large sample (n = 2400) of 7-m penalty throws in team handball that includes 1600 disguised throws. Throws were performed by both novice (n = 5) and expert (n = 5) penalty takers. The article reports the methods and materials used to capture the motion data. The database itself is accessible for download via JLU Web Server and provides all raw files in a three-dimensional motion data format (.c3d). Additional information is given on the marker placement of the penalty taker, goalkeeper, and ball together with details on the skill level and/or playing history of the expert group...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29158855/clinical-evaluation-of-terap-c-vaccine-in-combined-treatment-with-interferon-and-ribavirin-in-patients-with-hepatitis-c
#12
Dorta Guridi Zaily, Castellanos Fernandez Marlen, Dueñas-Carrera Santiago, Martínez Donato Gillian, Valenzuela Silva Carmen, Cinza Estevez Zurina, Arús Soler Enrique R, Alvarez-Lajonchere Liz, González Fabián Lisset, Lazo Del Vallín Sacha, Ferrer Bataille Elena
Background: An estimated 170 million individuals worldwide are infected with the hepatitis C virus (HCV). Although treatment options using a combination of pegylated interferon and ribavirin (P-IFN/RBV) are available, sustained clearance of the virus is only achieved in approximately 40% of individuals infected with HCV genotype 1. Recent advances in the treatment of HCV using directly acting antiviral agents have been achieved; however, treatment can be very expensive and is associated with substantial side effects...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29158853/diagnosis-and-treatment-of-autoimmune-liver-diseases-in-a-tertiary-referral-center-in-cuba
#13
Marlen Ivón Castellanos Fernández, Deyanira la Rosa Hernández, Diego Enrique Cabrera Eugenio, Wilson Palanca, Zaily Dorta Guridi, Licet González Fabián
Background: Autoimmune liver diseases (AILD) comprise a set of entities characterized by tissue damage as a result of the loss of self-tolerance. There are few reports of AILD from Caribbean countries. Objectives: The aim of our study was to investigate the clinical patterns, laboratory findings, and immunologic features, treatment responses, and prognoses of AILD in adult patients at a Cuban tertiary referral center. Methods: A prospective study was conducted at the National Institute of Gastroenterology in Havana, Cuba, from May 2012 to April 2016...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29158839/characterization-of-cardiac-dynamics-in-an-acute-myocardial-infarction-model-by-four-dimensional-optoacoustic-and-magnetic-resonance-imaging
#14
Hsiao-Chun Amy Lin, Xosé Luís Déan-Ben, Ivana Ivankovic, Melanie A Kimm, Katja Kosanke, Helena Haas, Reinhard Meier, Fabian Lohöfer, Moritz Wildgruber, Daniel Razansky
Extraction of murine cardiac functional parameters on a beat-by-beat basis is limited with the existing imaging modalities due to insufficient three-dimensional temporal resolution. Faster volumetric imaging methods enabling in vivo characterization of functional parameters are poised to advance cardiovascular research and provide a better understanding of the mechanisms underlying cardiac diseases. We present a new approach based on analyzing contrast-enhanced optoacoustic (OA) images acquired at high volumetric frame rate without using cardiac gating or other approaches for motion correction...
2017: Theranostics
https://www.readbyqxmd.com/read/29155908/iminium-and-enamine-catalysis-in-enantioselective-photochemical-reactions
#15
You-Quan Zou, Fabian M Hörmann, Thorsten Bach
Although enantioselective catalysis under thermal conditions has been well established over the last few decades, the enantioselective catalysis of photochemical reactions is still a challenging task resulting from the complex enantiotopic face differentiation in the photoexcited state. Recently, remarkable achievements have been reported by a synergistic combination of organocatalysis and photocatalysis, which have led to the expedient construction of a diverse range of enantioenriched molecules which are generally not easily accessible under thermal conditions...
November 20, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29155036/effectiveness-of-app-based-self-acupressure-for-women-with-menstrual-pain-compared-to-usual-care-a-randomized-pragmatic-trial
#16
Susanne Blödt, Daniel Pach, Sanna von Eisenhart-Rothe, Fabian Lotz, Stephanie Roll, Katja Icke, Claudia M Witt
BACKGROUND: Primary dysmenorrhea is common among women of reproductive age. Non-steroidal anti-inflammatory drugs and oral contraceptives are effective treatments, although the failure rate is around 20-25%. Therefore additional evidence-based treatments are needed. In recent years, the use of smartphone applications (apps) has increased rapidly and may support individuals in self-management strategies. OBJECTIVE: We aimed to investigate the effectiveness of app-based self-acupressure in women with menstrual pain...
November 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29153956/effect-of-laser-activated-bleaching-on-the-chemical-stability-and-morphology-of-intracoronal-dentin
#17
Fabiane Carneiro Lopes, Renato Roperto, Anna Akkus, Ozan Akkus, Regina Guenka Palma-Dibb, Manoel Damião de Sousa-Neto
OBJECTIVES: To evaluate the effect of the bleaching with 35% hydrogen peroxide either activated or not by a 970nm diode laser on the chemical stability and dentin surface morphology of intracoronary dentin. METHODS: Twenty-seven slabs of intracoronary dentin specimens (3×3mm) were distributed into three groups (n=9), according to surface treatment: HP - 35% hydrogen peroxide (1×4'), DL - 970nm diode laser (1×30"/0,8W/10Hz), HP+DL - 35% HP activated with 970nm diode laser (1×30"/0,8W/10Hz leaving the gel in contact to the surface for 4' after activation)...
November 13, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29153460/real-world-procedural-and-30-day-outcome-using-the-portico-transcatheter-aortic-valve-prosthesis-a-large-single-center-cohort
#18
Andrea Denegri, Fabian Nietlispach, Jan Kottwitz, Gabor Suetsch, Philipp Haager, Hector Rodriguez, Maurizio Taramasso, Slayman Obeid, Francesco Maisano
BACKGROUND: Published procedural and short-term outcome of the Portico valve for Transcatheter Aortic Valve Implantation (TAVI) is limited. We report a single-center patient series assessing procedural and 30-day outcome of this device. METHODS AND RESULTS: Procedural and 30-day follow-up data were prospectively collected from a consecutive series of 73 patients (80.7±6.9years, 45% male, mean STS score: 4.8±3.9) with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI)...
November 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29152450/studying-slippage-on-pushing-applications-with-snake-robots
#19
Fabian Reyes, Shugen Ma
In this paper, a framework for analyzing the motion resulting from the interaction between a snake robot and an object is shown. Metrics are derived to study the motion of the object and robot, showing that the addition of passive wheels to the snake robot helps to minimize slippage. However, the passive wheels do not have a significant impact on the force exerted onto the object. This puts snake robots in a similar framework as robotic arms, while considering special properties exclusive to snake robots (e...
2017: Robotics and Biomimetics
https://www.readbyqxmd.com/read/29152245/metabolic-syndrome-and-inflammation-in-adipose-tissue-occur-at-different-times-in-animals-submitted-to-a-high-sugar-fat-diet
#20
Fabiane Valentini Francisqueti, André Ferreira Nascimento, Igor Otávio Minatel, Marcos Correa Dias, Renata de Azevedo Melo Luvizotto, Carolina Berchieri-Ronchi, Ana Lúcia A Ferreira, Camila Renata Corrêa
Obesity is associated with low-grade inflammation, triggered in adipose tissue, which may occur due to an excess of SFA from the diet that can be recognised by Toll-like receptor-4. This condition is involved in the development of components of the metabolic syndrome associated with obesity, especially insulin resistance. The aim of the study was to evaluate the manifestation of the metabolic syndrome and adipose tissue inflammation as a function of the period of time in which rats were submitted to a high-sugar/fat diet (HSF)...
2017: Journal of Nutritional Science
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