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https://www.readbyqxmd.com/read/29792401/synthetic-single-domain-antibodies-for-the-conformational-trapping-of-membrane-proteins
#1
Iwan Zimmermann, Pascal Egloff, Cedric Aj Hutter, Fabian M Arnold, Peter Stohler, Nicolas Bocquet, Melanie N Hug, Sylwia Huber, Martin Siegrist, Lisa Hetemann, Jennifer Gera, Samira Gmür, Peter Spies, Daniel Gygax, Eric R Geertsma, Roger Jp Dawson, Markus A Seeger
Mechanistic and structural studies of membrane proteins require their stabilization in specific conformations. Single domain antibodies are potent reagents for this purpose, but their generation relies on immunizations, which impedes selections in the presence of ligands typically needed to populate defined conformational states. To overcome this key limitation, we developed an in vitro selection platform based on synthetic single domain antibodies named sybodies. To target the limited hydrophilic surfaces of membrane proteins, we designed three sybody libraries that exhibit different shapes and moderate hydrophobicity of the randomized surface...
May 24, 2018: ELife
https://www.readbyqxmd.com/read/29790605/cd57-identifies-t-cells-with-functional-senescence-before-terminal-differentiation-and-relative-telomere-shortening-in-patients-with-activated-pi3-kinase-delta-syndrome
#2
Paola Cura Daball, Monica Sofia Ventura Ferreira, Sandra Ammann, Christian Klemann, Myriam Ricarda Lorenz, Ursula Warthorst, T Ronan Leahy, Niall Conlon, Justin Roche, Pere Soler-Palacín, Marina Garcia-Prat, Ilka Fuchs, Sebastian Fuchs, Fabian Beier, Tim H Brümmendorf, Carsten Speckmann, Peter Olbrich, Olaf Neth, Klaus Schwarz, Stephan Ehl, Anne Rensing-Ehl
Premature T cell immunosenescence with CD57+ CD8+ T cell accumulation has been linked to immunodeficiency and autoimmunity in primary immunodeficiencies including activated PI3 kinase delta syndrome (APDS). To address whether CD57 marks the typical senescent T cell population seen in adult individuals or identifies a distinct population in APDS, we compared CD57+ CD8+ T cells from mostly pediatric APDS patients to those of healthy adults with similarly prominent senescent T cells. CD57+ CD8+ T cells from APDS patients were less differentiated with more CD27+ CD28+ effector memory cells showing increased PD1 and Eomesodermin expression...
May 23, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29790269/thermally-activated-self-metalation-of-carboxy-functionalized-porphyrin-films-on-mgo-nanocubes
#3
Fabian Kollhoff, Johannes Schneider, Thomas Berger, Oliver Diwald, Jörg Libuda
We investigated the adsorption of different free-base carboxyl-functionalized porphyrins, 5,10,15,20-tetrakis(4-carboxyphenyl)-21,23H-porphyrin (2H-TCPP) and 5(4-carboxyphenyl)-10,15, 20-triphenyl-21,23H-porphyrin (2H-MCTPP), on MgO nanocubes combining IR, UV-Vis and photoluminescence emission spectroscopy. The thermal behaviour of the films was monitored in-situ during annealing. Both porphyrins bind to the nanocubes by via one and two acid groups respectively, yielding monolayer films consisting of tilted molecules...
May 23, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29789449/automatic-identification-of-alpine-mass-movements-by-a-combination-of-seismic-and-infrasound-sensors
#4
Andreas Schimmel, Johannes Hübl, Brian W McArdell, Fabian Walter
The automatic detection and identification of alpine mass movements such as debris flows, debris floods, or landslides have been of increasing importance for devising mitigation measures in densely populated and intensively used alpine regions. Since these mass movements emit characteristic seismic and acoustic waves in the low-frequency range (.
May 22, 2018: Sensors
https://www.readbyqxmd.com/read/29788135/the-hepatic-glucocorticoid-receptor-is-crucial-for-cortisol-homeostasis-and-sepsis-survival-in-humans-and-male-mice
#5
Marc Jenniskens, Ruben Weckx, Thomas Dufour, Sarah Vander Perre, Lies Pauwels, Sarah Derde, Arno Téblick, Fabian Güiza, Greet Van den Berghe, Lies Langouche
Sepsis is hallmarked by hypercortisolemia, a stress response that is essential for survival. This elevation in plasma cortisol is partially brought about by suppressed hepatic cortisol breakdown. We now demonstrated that a controlled downregulation of the hepatic glucocorticoid receptor (hepatic GR) is crucial herein. In a mouse model of fluid-resuscitated, antibiotic-treated abdominal sepsis and in human ICU patients, sepsis reduced hepatic GR expression and signaling, but increased (free) plasma cortisol/corticosterone, explained by suppressed cortisol/corticosterone binding proteins and A-ring-reductases...
May 17, 2018: Endocrinology
https://www.readbyqxmd.com/read/29785173/phytochemicals-that-influence-gut-microbiota-as-prophylactics-and-for-the-treatment-of-obesity-and-inflammatory-diseases
#6
REVIEW
Lucrecia Carrera-Quintanar, Rocío I López Roa, Saray Quintero-Fabián, Marina A Sánchez-Sánchez, Barbara Vizmanos, Daniel Ortuño-Sahagún
Gut microbiota (GM) plays several crucial roles in host physiology and influences several relevant functions. In more than one respect, it can be said that you "feed your microbiota and are fed by it." GM diversity is affected by diet and influences metabolic and immune functions of the host's physiology. Consequently, an imbalance of GM, or dysbiosis, may be the cause or at least may lead to the progression of various pathologies such as infectious diseases, gastrointestinal cancers, inflammatory bowel disease, and even obesity and diabetes...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29783114/geosphere-biosphere-circulation-of-chemical-elements-in-soil-and-plant-systems-from-a-100-km-transect-from-southern-central-norway
#7
Clemens Reimann, Karl Fabian, Belinda Flem, Malin Andersson, Peter Filzmoser, Peter Englmaier
Geochemical element separation is studied in 14 different sample media collected at 41 sites along an approximately 100-km long transect north of Oslo. At each site, soil C and O horizons and 12 plant materials (birch/spruce/cowberry/blueberry leaves/needles and twigs, horsetail, braken fern, pine bark and terrestrial moss) were sampled. The observed concentrations of 29 elements (K, Ca, P, Mg, Mn, S, Fe, Zn, Na, B, Cu, Mo, Co, Al, Ba, Rb, Sr, Ti, Ni, Pb, Cs, Cd, Ce, Sn, La, Tl, Y, Hg, Ag) were used to investigate soil-plant relations, and to evaluate the element differentiation between different plants, or between foliage and twigs of the same plant...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29782696/routine-antenatal-ultrasound-in-low-and-middle-income-countries-first-look-a-cluster-randomized-trial
#8
Robert L Goldenberg, Robert O Nathan, David Swanson, Sarah Saleem, Waseem Mirza, Fabian Esamai, David Muyodi, Ana L Garces, Lester Figueroa, Elwyn Chomba, Melody Chiwala, Musaku Mwenechanya, Antoinette Tshefu, Adrien Lokangako, Victor Lokomba Bolamba, Janet L Moore, Holly Franklin, Jonathan Swanson, Edward A Liechty, Carl L Bose, Nancy F Krebs, K Michael Hambidge, Waldemar A Carlo, Nancy Kanaiza, Farnaz Naqvi, Irma Sayury Pineda, Walter López-Gomez, Dorothy Hamsumonde, Margo S Harrison, Marion Koso-Thomas, Menachem Miodovnik, Dennis D Wallace, Elizabeth M McClure
OBJECTIVE: Ultrasound is widely regarded as an important adjunct to antenatal care (ANC) to guide practice and reduce perinatal mortality. We assessed the impact of ANC ultrasound use at health centers in resource-limited countries. DESIGN: Cluster randomized trial. SETTING: Clusters within five countries (Democratic Republic of Congo, Guatemala, Kenya, Pakistan and Zambia). METHODS: Clusters were randomized to standard ANC or standard care plus two ultrasounds and referral for complications...
May 21, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29781368/the-role-of-the-oncogenic-rab35-in-cancer-invasion-metastasis-and-immune-evasion-especially-in-leukemia
#9
Fabian R Villagomez, Oscar Medina-Contreras, Jorge Francisco Cerna-Cortes, Genaro Patino-Lopez
The study of cancer has allowed researchers to describe some biological characteristics that tumor cells acquire during their development, known as the "hallmarks of cancer" but more research is needed to expand our knowledge about cancer biology and to generate new strategies of treatment. The role that RabGTPases might play in some hallmarks of cancer represents interesting areas of study since these proteins are frequently altered in cancer. However, their participation is not well known. Recently, Rab35was recognized as an oncogenic RabGTPase and and because of its association with different cellular functions, distinctly important in immune cells, a possible role of Rab35 in leukemia can be suggested...
May 21, 2018: Small GTPases
https://www.readbyqxmd.com/read/29781017/buckminsterfullerene-hybridized-zinc-oxide-tetrapods-defects-and-charge-transfer-induced-optical-and-electrical-response
#10
Daria Smazna, Joana Rodrigues, Sindu Shree, Vasile Postica, Gero Neubüser, A F Martins, N Ben Sedrine, Naresh K Jena, Leonard Siebert, Fabian Schütt, Oleg Lupan, Rajeev Ahuja, M R Correia, Teresa Monteiro, Lorenz Kienle, Ya Yang, Rainer Adelung, Yogendra Kumar Mishra
Buckminster fullerene (C60) based hybrid metal oxide materials are receiving considerable attention because of their excellent fundamental and applied aspects, like semiconducting, electron transfer, luminescent behaviors, etc. and this work briefly discusses the successful fabrication of C60 decorated ZnO tetrapod materials and their detailed structure-property relationships including device sensing applications. The electron microscopy investigations indicate that a quite dense surface coverage of ZnO tetrapods with C60 clusters is achieved...
May 21, 2018: Nanoscale
https://www.readbyqxmd.com/read/29780804/active-ageing-in-europe-adding-healthy-life-to-years
#11
Giuseppe Liotta, Helena Canhao, Fabian Cenko, Rita Cutini, Ercole Vellone, Maddalena Illario, Przemyslaw Kardas, Andrea Poscia, Rute Dinis Sousa, Leonardo Palombi, Maria Cristina Marazzi
No abstract text is available yet for this article.
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29780715/endovascular-treatment-of-acute-type-a-aortic-dissection-the-endo-bentall-approach
#12
Maximilian Kreibich, Bartosz Rylski, Stoyan Kondov, Julia Morlock, Johannes Scheumann, Fabian A Kari, Holger Schröfel, Matthias Siepe, Friedhelm Beyersdorf, Martin Czerny
Outcome after classical surgical repair of acute Type A aortic dissection has steadily improved over the years and several modifications in cannulation and perfusion added to this achievement. However, subgroups remain where results of classical surgical repair still have room for improvement, particularly patients with severe preoperative malperfusion as well as elderly patients with a limited physiological reserve. So far, only small case series or case reports have been published on the endovascular treatment of dissected ascending aortas...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29780477/donor-acceptor-interactions-between-cyclic-trinuclear-pyridinate-gold-i-complexes-and-electron-poor-guests-nature-and-energetics-of-guest-binding-and-templating-on-graphite
#13
Raiko Hahn, Fabian Bohle, Stefan Kotte, Tristan J Keller, Stefan-S Jester, Andreas Hansen, Stefan Grimme, Birgit Esser
Donor-acceptor-type interactions between π-electron systems are of high relevance in the design of chemical sensors. Due to their electron-rich nature, cyclic trinuclear complexes (CTCs) of gold(i) are ideal receptor sites for electron-deficient aromatic analytes. Scanning tunneling microscopy provided insight into the structures of two-dimensional crystals of pyridinate gold CTCs that form on a graphite template at the solid/liquid interface. One polymorph thereof - in turn - templated the on-top co-adsorption of π-acidic pyrazolate CTCs as electron-poor guests up to a certain threshold...
April 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29779897/inductive-and-selective-effects-of-gsk3-and-mek-inhibition-on-nanog-heterogeneity-in-embryonic-stem-cells
#14
Simon Hastreiter, Stavroula Skylaki, Dirk Loeffler, Andreas Reimann, Oliver Hilsenbeck, Philipp S Hoppe, Daniel L Coutu, Konstantinos D Kokkaliaris, Michael Schwarzfischer, Konstantinos Anastassiadis, Fabian J Theis, Timm Schroeder
Embryonic stem cells (ESCs) display heterogeneous expression of pluripotency factors such as Nanog when cultured with serum and leukemia inhibitory factor (LIF). In contrast, dual inhibition of the signaling kinases GSK3 and MEK (2i) converts ESC cultures into a state with more uniform and high Nanog expression. However, it is so far unclear whether 2i acts through an inductive or selective mechanism. Here, we use continuous time-lapse imaging to quantify the dynamics of death, proliferation, and Nanog expression in mouse ESCs after 2i addition...
May 10, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29778909/n-acetylcysteine-protects-against-diabetic-nephropathy-through-control-of-oxidative-and-nitrosative-stress-by-recovery-of-nitric-oxide-in-rats
#15
Guilherme B Nogueira, Giovana R Punaro, Clemerson S Oliveira, Fabiane R Maciel, Thamires O Fernandes, Deyse Y Lima, Adelson M Rodrigues, Margaret G Mouro, Sergio R R Araujo, Elisa M S Higa
The diabetes mellitus (DM) induces several changes, with substantial increase of reactive oxygen species (ROS). The ROS cause damage to systemic and renal microvasculature, which could be one of the mechanisms involved in the development of diabetic nephropathy (DN). The ROS modulate other substances like the nitric oxide (NO), a vasodilator with important role in the renal function. N-acetylcysteine (NAC) is an antioxidant that acts replenishing intracellular cysteine levels, which is essential for glutathione formation...
May 17, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29777245/growth-assessment-and-monitoring-during-childhood
#16
Fabian Yap, Yung Seng Lee, Marion Margaret Hy Aw
Growth is an indicator of the health and nutritional status of infants and children. Health organisations and professionals worldwide advocate monitoring the growth of children with the primary aim of identifying and preventing malnutrition and/or obesity. Growth monitoring should be part of every health care consultation for children. However, physicians during health care consultations are often so busy addressing acute health issues, that they miss the opportunity to monitor the child's growth and provide anticipatory guidance...
April 2018: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29776348/the-influence-of-cross-sectoral-treatment-models-on-patients-with-mental-disorders-in-germany-study-protocol-of-a-nationwide-long-term-evaluation-study-eva64
#17
Anne Neumann, Enno Swart, Dennis Häckl, Roman Kliemt, Stefanie March, Denise Küster, Katrin Arnold, Thomas Petzold, Fabian Baum, Martin Seifert, Jessika Weiß, Andrea Pfennig, Jochen Schmitt
BACKGROUND: Close, continuous and efficient collaboration between different professions and sectors of care is necessary to provide patient-centered care for individuals with mental disorders. The lack of structured collaboration between in- and outpatient care constitutes a limitation of the German health care system. Since 2012, a new law in Germany (§64b Social code book (SGB) V) has enabled the establishment of cross-sectoral and patient-centered treatment models in psychiatry. Such model projects follow a capitation budget, i...
May 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29776311/phospholipid-block-copolymer-hybrid-vesicles-with-lysosomal-escape-ability
#18
Wei Zong, Bo Thingholm, Fabian Itel, Philipp Sebastian Schattling, Edit Brodszkij, Daniel Mayer, Steffen Stenger, Kenneth N Goldie, Xiaojun Han, Brigitte Städler
The success of nanoparticulate formulations in drug delivery depends on various aspects including their toxicity, internalization and intracellular location. Vesicular assemblies consisting of phospholipid and amphiphilic block copolymers are an emerging platform, which combines the benefits from liposomes and polymersomes while overcoming their challenges. We report the synthesis of poly(cholesteryl methacrylate)-block-poly(2-(dimethylamino) ethyl methacrylate) (pCMA-b-pDMAEMA) block copolymers and their assembly with phospholipids into hybrid vesicles...
May 18, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29776129/assay-based-on-electrical-impedance-spectroscopy-to-discriminate-between-normal-and-cancerous-mammalian-cells
#19
Fabián Eduardo Giana, Fabián José Bonetto, Mariela Inés Bellotti
In this work we present an assay to discriminate between normal and cancerous cells. The method is based on the measurement of electrical impedance spectra of in vitro cell cultures. We developed a protocol consisting on four consecutive measurement phases, each of them designed to obtain different information about the cell cultures. Through the analysis of the measured data, 26 characteristic features were obtained for both cell types. From the complete set of features, we selected the most relevant in terms of their discriminant capacity by means of conventional statistical tests...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29775577/caspase-3-regulates-yap-dependent-cell-proliferation-and-organ-size
#20
Yahav Yosefzon, Despina Soteriou, Alona Feldman, Lana Kostic, Elle Koren, Samara Brown, Roi Ankawa, Egor Sedov, Fabian Glaser, Yaron Fuchs
Apoptosis culminates in the activation of caspase-3, which plays an important role in implementing the cell death program. Here, we reveal a non-apoptotic role of caspase-3 as a key regulator of cell proliferation and organ size. Caspase-3 is specifically activated in the proliferating cells of the sebaceous gland, but does not instruct cell elimination. Deletion or chemical inhibition of caspase-3 diminishes cell proliferation, decreases cell number and reduces sebaceous gland size in vivo. Exploring the underlying mechanism, we demonstrate that α-catenin is cleaved by caspase-3, thus facilitating the activation and nuclear translocation of yes-associated protein (YAP), a vital regulator of organ size...
May 17, 2018: Molecular Cell
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