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https://www.readbyqxmd.com/read/28080187/early-life-risk-factors-for-testicular-cancer-a-case-cohort-study-based-on-the-copenhagen-school-health-records-register
#1
Johanne Spanggaard Piltoft, Signe Benzon Larsen, Susanne Oksbjerg Dalton, Christoffer Johansen, Jennifer L Baker, Luise Cederkvist, Ingelise Andersen
PURPOSE: One established risk factors for testicular cancer is cryptorchidism. However, it remains unclear whether cryptorchidism is a risk factor in itself or whether the two conditions share common causes in early life (estrogen hypothesis), such as birth weight and birth order. The objective of this study is to utilize data from the Copenhagen School Health Records Register (CSHRR) to evaluate cryptorchidism, birth weight and birth order as risk factors for testicular cancer. METHODS: The study population consisted of 408 cases of testicular cancer identified by a government issued identification number linkage of the entire CSHRR with the Danish Cancer Registry and a random subsample of 4819 males from the CSHRR...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28079726/the-charter-on-professionalism-for-health-care-organizations
#2
Barry E Egener, Diana J Mason, Walter J McDonald, Sally Okun, Meg E Gaines, David A Fleming, Bernie M Rosof, David Gullen, May-Lynn Andresen
In 2002, the Physician Charter on Medical Professionalism was published to provide physicians with guidance for decision making in a rapidly changing environment. Feedback from physicians indicated that they were unable to fully live up to the principles in the 2002 charter partly because of their employing or affiliated health care organizations. A multistakeholder group has developed a Charter on Professionalism for Health Care Organizations, which may provide more guidance than charters for individual disciplines, given the current structure of health care delivery systems...
January 10, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28077618/mechanism-of-nuclear-movements-in-a-multinucleated-cell
#3
Romain Gibeaux, Antonio Z Politi, Peter Philippsen, François Nédélec
Multinucleated cells are important in many organisms but the mechanisms governing the movements of nuclei sharing a common cytoplasm are not understood. In the hyphae of the plant pathogenic fungus Ashbya gossypii, nuclei move back and forth, occasionally bypassing each other, and, preventing the formation of nuclear clusters, this is essential for genetic stability. These movements depend on cytoplasmic microtubules emanating from the nuclei, that are pulled by dynein motors anchored at the cortex. Using 3D stochastic simulations with parameters constrained by the literature, we predict the cortical anchors density from the characteristics of nuclear movements...
January 11, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28072526/type-i-dna-topoisomerases
#4
Giovanni Capranico, Jessica Marinello, Giovanni Chillemi
DNA topoisomerases constitute a large family of essential enzymes in all domains of life. Even though they share the general reaction chemistry and the ability to govern DNA topology and resolve strand entanglements during fundamental molecular processes, they are characterized by differences in structural organization, modes of enzymatic catalysis and biological functions. Moreover, hundreds of compounds are known to interfere with bacterial and/or eukaryotic enzymes, and some of them are effective drugs for the treatment of infectious diseases and cancers...
January 10, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28067681/a-response-to-the-question-of-professional-governance-versus-shared-governance
#5
Tim Porter-O'Grady
No abstract text is available yet for this article.
January 7, 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28063724/pressure-injury-prevalence-in-intensive-care-versus-non-intensive-care-patients-a-state-wide-comparison
#6
Fiona Coyer, Sandra Miles, Sandra Gosley, Paul Fulbrook, Kirstine Sketcher-Baker, Jane-Louise Cook, Jacqueline Whitmore
BACKGROUND: Hospital-acquired pressure injury is associated with increased morbidity and mortality and considered to be largely preventable. Pressure injury prevalence is regarded as a marker of health care quality. OBJECTIVE: To compare the state-wide prevalence, severity and location of pressure injuries of intensive care unit patients compared to patients in non-intensive care wards. METHOD: The study employed a secondary data analysis design to extract and analyse de-identified pressure injury data from all Queensland Health hospitals with level I-III intensive care facilities that participated in Queensland Bedside Audits between 2012-2014...
January 4, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28056098/a-model-for-good-governance-of-healthcare-technology-management-in-the-public-sector-learning-from-evidence-informed-policy-development-and-implementation-in-benin
#7
P Th Houngbo, H L S Coleman, M Zweekhorst, Tj De Cock Buning, D Medenou, J F G Bunders
Good governance (GG) is an important concept that has evolved as a set of normative principles for low- and middle-income countries (LMICs) to strengthen the functional capacity of their public bodies, and as a conditional prerequisite to receive donor funding. Although much is written on good governance, very little is known on how to implement it. This paper documents the process of developing a strategy to implement a GG model for Health Technology Management (HTM) in the public health sector, based on lessons learned from twenty years of experience in policy development and implementation in Benin...
2017: PloS One
https://www.readbyqxmd.com/read/28053058/mouthpart-conduit-sizes-of-fluid-feeding-insects-determine-the-ability-to-feed-from-pores
#8
Matthew S Lehnert, Andrew Bennett, Kristen E Reiter, Patrick D Gerard, Qi-Huo Wei, Miranda Byler, Huan Yan, Wah-Keat Lee
Fluid-feeding insects, such as butterflies, moths and flies (20% of all animal species), are faced with the common selection pressure of having to remove and feed on trace amounts of fluids from porous surfaces. Insects able to acquire fluids that are confined to pores during drought conditions would have an adaptive advantage and increased fitness over other individuals. Here, we performed feeding trials using solutions with magnetic nanoparticles to show that butterflies and flies have mouthparts adapted to pull liquids from porous surfaces using capillary action as the governing principle...
January 11, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28049454/identifying-mechanisms-for-facilitating-knowledge-to-action-strategies-targeting-the-built-environment
#9
Ghazal S Fazli, Maria I Creatore, Flora I Matheson, Sara Guilcher, Vered Kaufman-Shriqui, Heather Manson, Ashley Johns, Gillian L Booth
BACKGROUND: In recent years, obesity-related diseases have been on the rise globally resulting in major challenges for health systems and society as a whole. Emerging research in population health suggests that interventions targeting the built environment may help reduce the burden of obesity and type 2 diabetes. However, translation of the evidence on the built environment into effective policy and planning changes requires engagement and collaboration between multiple sectors and government agencies for designing neighborhoods that are more conducive to healthy and active living...
January 3, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28047638/su-f-p-09-a-global-medical-physics-collaboration-for-implementation-of-modern-radiotherapy-in-botswana
#10
R Makufa, M Bvochora-Nsingo, T Karumekayi, R J Schneider, J A Efstathiou, S Dryden-Peterson, A Odom, A Shulman, Y Pipman, D P Gierga
PURPOSE: The global burden of cancer is considerable, particularly in low and middle-income countries. Massachusetts General Hospital (MGH) and Botswana-Harvard AIDS Institute have partnered with the oncology community and government of Botswana to form BOTSOGO (BOTSwana Oncology Global Outreach) to address the rising burden of cancer in Botswana. Currently, radiation therapy (RT) is only available at a single linear accelerator (LINAC) in Gaborone Private Hospital (GPH). BOTSOGO worked to limit the absence of RT during a LINAC upgrade and ensure a safe transition to modern radiotherapy techniques...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28034410/a-review-of-electronic-medical-record-keeping-on-mobile-medical-service-trips-in-austere-settings
#11
REVIEW
Christopher Dainton, Charlene H Chu
INTRODUCTION: Electronic medical records (EMRs) may address the need for decision and language support for Western clinicians on mobile medical service trips (MSTs) in low resource settings abroad, while providing improved access to records and data management. However, there has yet to be a review of this emerging technology used by MSTs in low-resource settings. The aim of this study is to describe EMR systems designed specifically for use by mobile MSTs in remote settings, and accordingly, determine new opportunities for this technology to improve quality of healthcare provided by MSTs...
February 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28027707/exploring-global-history-through-the-lens-of-history-of-chemistry-materials-identities-and-governance
#12
Lissa Roberts
As global history continues to take shape as an important field of research, its interactive relationships with the history of science, technology, and medicine are recognized and being investigated as significant areas of concern. Strangely, despite the fact that it is key to understanding so many of the subjects that are central to global history and would itself benefit from a broader geographical perspective, the history of chemistry has largely been left out of this process - particularly for the modern historical period...
December 2016: History of Science; An Annual Review of Literature, Research and Teaching
https://www.readbyqxmd.com/read/28027482/developing-national-best-practice-recommendations-for-harm-reduction-programmes-lessons-learned-from-a-community-based-project
#13
Tara Marie Watson, Carol Strike, Laurel Challacombe, Geoff Demel, Diana Heywood, Nadia Zurba
Through promotion of consistent, evidence-based policy and practice, best practice recommendations can improve service delivery. Nationally relevant best practice recommendations, including guidance for programmes that provide service to people who use drugs, are often created and disseminated by government departments or other national organisations. However, funding priorities do not always align with stakeholder- and community-identified needs for such recommendations, particularly in the case of harm reduction...
December 24, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28027158/meeting-regulatory-needs
#14
Michael Fred Weber
The world is experiencing change at an unprecedented pace, as reflected in social, cultural, economic, political, and technological advances around the globe. Regulatory agencies, like the U.S. Nuclear Regulatory Commission (NRC), must also transform in response to and in preparation for these changes. In 2014, the NRC staff commenced Project Aim 2020 to transform the agency by enhancing efficiency, agility, and responsiveness, while accomplishing NRC's safety and security mission. Following Commission review and approval in 2015, the NRC began implementing the approved strategies, including strategic workforce planning to provide confidence that NRC will have employees with the right skills and talents at the right time to accomplish the agency's mission...
February 2017: Health Physics
https://www.readbyqxmd.com/read/28026696/capacity-building-in-human-resources-for-health-the-experience-of-the-region-of-the-americas
#15
Charles Godue, Rick Cameron, Rosa Maria Borrell
SETTING: Since the year 2003, most countries of the Region of the Americas have experienced sustained economic growth and inclusive development policies. In the health sector, achieving universal access became the overarching goal. However, the structural limitations of the health workforce represented a formidable obstacle to change. National Health Authorities were confronted with the challenge of developing critical capacities to redress entrenched inequalities in access to qualified health personnel...
December 27, 2016: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28024947/clinical-genomic-profiling-of-a-diverse-array-of-oncology-specimens-at-a-large-academic-cancer-center-identification-of-targetable-variants-and-experience-with-reimbursement
#16
Anthony N Sireci, Vimla S Aggarwal, Andrew T Turk, Tatyana Gindin, Mahesh M Mansukhani, Susan J Hsiao
Large cancer panels are being increasingly used in the practice of precision medicine to generate genomic profiles of tumors with the goal of identifying targetable variants and guiding eligibility for clinical trials. To facilitate identification of mutations in a broad range of solid and hematological malignancies, a 467-gene oncology panel (Columbia Combined Cancer Panel) was developed in collaboration with pathologists and oncologists and is currently available and in use for clinical diagnostics. Herein, we share our experience with this testing in an academic medical center...
December 23, 2016: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28024240/governance-of-global-health-research-consortia-sharing-sovereignty-and-resources-within-future-health-systems
#17
Bridget Pratt, Adnan A Hyder
Global health research partnerships are increasingly taking the form of consortia that conduct programs of research in low and middle-income countries (LMICs). An ethical framework has been developed that describes how the governance of consortia comprised of institutions from high-income countries and LMICs should be structured to promote health equity. It encompasses initial guidance for sharing sovereignty in consortia decision-making and sharing consortia resources. This paper describes a first effort to examine whether and how consortia can uphold that guidance...
November 29, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/28008234/the-australasian-hepatology-association-consensus-guidelines-for-the-provision-of-adherence-support-to-patients-with-hepatitis-c-on-direct-acting-antivirals
#18
Jacqueline A Richmond, Suzanne Sheppard-Law, Susan Mason, Sherryne L Warner
BACKGROUND: Hepatitis C is a blood-borne virus primarily spread through sharing of drug-injecting equipment. Approximately 150 million people worldwide and 230,000 Australians are living with chronic hepatitis C infection. In March 2016, the Australian government began subsidizing direct acting antivirals (DAAs) for the treatment of hepatitis C, which are highly effective (95% cure rate) and have few side effects. However, there is limited evidence to inform the provision of adherence support to people with hepatitis C on DAAs including the level of medication adherence required to achieve a cure...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28006745/structural-social-capital-and-local-level-forest-governance-do-they-inter-relate-a-mushroom-permit-case-in-catalonia
#19
Elena Gorriz-Mifsud, Laura Secco, Riccardo Da Re, Elena Pisani, José Antonio Bonet
In diffuse forest uses, like non-timber forest products' harvesting, the behavioural alignment of pickers is crucial for avoiding a "tragedy of the commons". Moreover, the introduction of policy tools such as a harvest permit system may help in keeping the activity under control. Besides the official enforcement, pickers' engagement may also derive from the perceived legitimate decision of forest managers and the community pressure to behave according to the shared values. Framed within the social capital theory, this paper examines three types of relations of rural communities in a protected area in Catalonia (Spain) where a system of mushroom picking permits was recently introduced...
March 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28004369/mycorrhizal-colonization-status-of-lowland-rice-oryza-sativa-l-in-the-southeastern-region-of-china
#20
Xun-Wen Chen, Fu-Yong Wu, Hui Li, Wai-Fung Chan, Sheng-Chun Wu, Ming-Hung Wong
The accumulation, distribution, and speciation of contaminants, such as arsenic, in rice can be affected by soil microorganisms such as arbuscular mycorrhizal fungi (AMF). As a potential measure to control contaminant acquisition in rice, the status and performance of AMF in the field need to be investigated. Root samples of rice plants were collected in seven different cities in Guangdong, Jiangxi, Hubei, and Jiangsu Provinces in China in order to investigate the colonization rate of AMF. The total DNA of the roots was extracted, followed by PCR and sequencing, and further confirmed the existence of AMF...
December 21, 2016: Environmental Science and Pollution Research International
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