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Shared Governance

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https://www.readbyqxmd.com/read/28328120/a-qualitative-study-of-adolescents-understanding-of-biobanks-and-their-attitudes-toward-participation-re-contact-and-data-sharing
#1
Andrea M Murad, Melanie F Myers, Susan D Thompson, Rachel Fisher, Armand H Matheny Antommaria
While biobanks have become more prevalent, little is known about adolescents' views of key governance issues. We conducted semi-structured interviews with adolescents between 15 and 17 years old to solicit their views. All interviews were audiotaped and transcribed. Two investigators coded the transcripts and resolved any discrepancies through consensus. We conducted 18 interviews before reaching data saturation. Four participants (22%) had previously heard of a biobank. Many participants had misunderstandings about biobanks, some of which persisted after education...
April 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28323097/direct-comparison-between-millifluidic-and-bulk-mixing-platform-in-the-synthesis-of-amorphous-drug-polysaccharide-nanoparticle-complex
#2
Bingxue Dong, Kunn Hadinoto
Amorphous drug-polysaccharide nanoparticle complex (or drug nanoplex) had emerged as an ideal supersaturating delivery system of poorly-soluble drugs attributed to its many attractive characteristics. Herein we presented for the first time direct comparison between two nanoplex synthesis platforms, i.e. millifluidics and bulk mixing, representing continuous and batch production modes, respectively. They were compared by the resultant nanoplex's (1) physical characteristics (size, zeta potential, and payload), (2) preparation efficiency, (3) storage stability, (4) dissolution rate/supersaturation generation, and (5) production consistency...
March 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28322931/the-alternatively-spliced-lrrfip1-isoform-1-is-a-key-regulator-of-the-wnt-%C3%AE-catenin-transcription-pathway
#3
Pauline Labbé, Emilie Faure, Simon Lecointe, Solena Le Scouarnec, Florence Kyndt, Marie Marrec, Thierry Le Tourneau, Bernard Offmann, Cécile Duplaà, Stéphane Zaffran, Jean Jacques Schott, Jean Merot
The GC-rich Binding Factor 2/Leucine Rich Repeat in the Flightless 1 Interaction Protein 1 gene (GCF2/LRRFIP1) is predicted to be alternatively spliced in five different isoforms. Although important peptide sequence differences are expected to result from this alternative splicing, to date, only the gene transcription regulator properties of LRRFIP1-Iso5 were unveiled. Based on molecular, cellular and biochemical data, we show here that the five isoforms define two molecular entities with different expression profiles in human tissues, subcellular localizations, oligomerization properties and transcription enhancer properties of the canonical Wnt pathway...
March 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28320410/bibliometric-analysis-of-medicine-related-publications-on-refugees-asylum-seekers-and-internally-displaced-people-2000-2015
#4
Waleed M Sweileh
BACKGROUND: Wars and violent domestic conflicts have forced millions of people to move outside their homes. Meeting the basic health needs of those people requires an understanding of research activity and research output on this topic. The objective of this study was to shed light on the quantity and impact of medicine - related publications on refugees, asylum seekers and internally displaced people (IDP). METHOD: Scopus database was used to retrieve required data...
March 20, 2017: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/28317033/returning-genome-sequences-to-research-participants-policy-and-practice
#5
Caroline F Wright, Anna Middleton, Jeffrey C Barrett, Helen V Firth, David R FitzPatrick, Matthew E Hurles, Michael Parker
Despite advances in genomic science stimulating an explosion of literature around returning health-related findings, the possibility of returning entire genome sequences to individual research participants has not been widely considered. Through direct involvement in large-scale translational genomics studies, we have identified a number of logistical challenges that would need to be overcome prior to returning individual genome sequence data, including verifying that the data belong to the requestor and providing appropriate informatics support...
February 24, 2017: Wellcome Open Res
https://www.readbyqxmd.com/read/28317004/changes-in-the-mass-merchandise-cigar-market-since-the-tobacco-control-act
#6
Cristine D Delnevo, Daniel P Giovenco, Erin J Miller Lo
OBJECTIVES: This study identifies the specific product characteristics driving mass-merchandise cigar sales in the context of the changing regulatory environment. METHODS: Cigar sales data in US convenience stores during 2008-2015 were purchased from Nielsen's Convenience Track system. Descriptive statistics highlight changes in the cigar market over time. RESULTS: Sales of flavored cigars increased by nearly 50% since 2008 and now make up over half of the cigar market...
April 2017: Tobacco Regulatory Science
https://www.readbyqxmd.com/read/28301510/investigation-on-law-and-economics-of-listed-companies-financing-preference-based-on-complex-network-theory
#7
Jian Yang, Shuying Bai, Zhao Qu, Hui Chang
In this paper, complex network theory is used to make time-series analysis of key indicators of governance structure and financing data. We analyze scientific listed companies' governance data from 2010 to 2014 and divide them into groups in accordance with the similarity they share. Then we select sample companies to analyze their financing data and explore the influence of governance structure on financing decision and the financing preference they display. This paper reviews relevant laws and regulations of financing from the perspective of law and economics, then proposes reasonable suggestions to consummate the law for the purpose of regulating listed companies' financing...
2017: PloS One
https://www.readbyqxmd.com/read/28300994/the-choking-game-a-new-craze-among-brazilian-children-and-young-people-psychophysiological-behavioral-and-epidemiological-characteristics-of-asphyxial-games
#8
Juliana Guilheri, Anne Andronikof, Latife Yazigi
The 'choking game' is a risk-taking behavior that has spread quickly among children and young people, causing dependence, accidents and even death, including in Brazil. These activities are performed in order to experience fleeting euphoric sensations, attracting numerous participants through the thousands of videos posted on YouTube. The problem of 'asphyxial games' can be observed in the Brazilian digital media, although there is a lack of scientific studies. Through a systematic review of the literature and complementary material, this paper aims to address the 'asphyxial games', warning about the psychophysiological and behavioral effects of these practices, while also presenting international epidemiological data...
March 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28300976/primary-health-care-reform-in-the-cities-of-lisbon-and-rio-de-janeiro-context-strategies-results-learning-and-challenges
#9
Daniel Soranz, Luís Augusto Coelho Pisco
On the 30th anniversary of Alma-Ata, the World Health Organization published in 2008 the "Primary Health Care Now More Than Ever" Report, calling on all governments to reflect on the need to reflect on four sets of reforms. These included: (i) universal coverage reforms; (ii) service delivery reforms; (iii) public policies reforms that would ensure healthier communities; and (iv) leadership reforms. In this context, in the period 2005-2016, the cities of Rio de Janeiro and Lisbon developed a profound primary healthcare reform, and did so by sharing many of the solutions based on the best internationally recognized organizational practices...
March 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28297677/recombinant-bcg-expressing-esx-1-of-mycobacterium-marinum-combines-low-virulence-with-cytosolic-immune-signaling-and-improved-tb-protection
#10
Matthias I Gröschel, Fadel Sayes, Sung Jae Shin, Wafa Frigui, Alexandre Pawlik, Mickael Orgeur, Robin Canetti, Nadine Honoré, Roxane Simeone, Tjip S van der Werf, Wilbert Bitter, Sang-Nae Cho, Laleh Majlessi, Roland Brosch
Recent insights into the mechanisms by which Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is recognized by cytosolic nucleotide sensors have opened new avenues for rational vaccine design. The only licensed anti-tuberculosis vaccine, Mycobacterium bovis BCG, provides limited protection. A feature of BCG is the partial deletion of the ESX-1 type VII secretion system, which governs phagosomal rupture and cytosolic pattern recognition, key intracellular phenotypes linked to increased immune signaling...
March 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28295669/supramolecular-covalence-in-bifurcated-chalcogen-bonding
#11
Pankaj Lochan Bora, Martin Novák, Jan Novotný, Cina Foroutan-Nejad, Radek Marek
Supramolecular interactions were generally classified as non-covalent. However, recent studies have demonstrated that many of these formally non-covalent interactions are stabilized by a significant covalent component. Herein we show for systems of the general structure [MX6]2-:YX2 (M = Se or Pt; Y = S, Se, or Te; X = F, Cl, Br, I) featuring bifurcated chalcogen bonding that, while the electrostatic parameters are useful for estimating the long-range electrostatic component of the interaction, they fail to predict the correct order of the binding energies in a series of compounds...
March 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28294293/current-barriers-and-potential-strategies-to-increase-the-use-of-long-acting-reversible-contraception-larc-to-reduce-the-rate-of-unintended-pregnancies-in-australia-an-expert-roundtable-discussion
#12
Danielle Mazza, Deborah Bateson, Meredith Frearson, Philip Goldstone, Gab Kovacs, Rod Baber
BACKGROUND: Australia's abortion rates are among the highest in the developed world. Efficacy of the most commonly used form of contraception (oral contraceptives and condoms) relies on regular user compliance. Long-acting reversible contraception (LARC) virtually eradicates contraceptive failure as it is not user-dependent; however, its uptake has been low. AIM: To provide an overview of barriers to LARC use in Australia and potential strategies to overcome these barriers...
March 10, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28285984/the-advance-code-of-conduct-for-collaborative-vaccine-studies
#13
REVIEW
Xavier Kurz, Vincent Bauchau, Patrick Mahy, Steffen Glismann, Lieke Maria van der Aa, François Simondon
Lessons learnt from the 2009 (H1N1) flu pandemic highlighted factors limiting the capacity to collect European data on vaccine exposure, safety and effectiveness, including lack of rapid access to available data sources or expertise, difficulties to establish efficient interactions between multiple parties, lack of confidence between private and public sectors, concerns about possible or actual conflicts of interest (or perceptions thereof) and inadequate funding mechanisms. The Innovative Medicines Initiative's Accelerated Development of VAccine benefit-risk Collaboration in Europe (ADVANCE) consortium was established to create an efficient and sustainable infrastructure for rapid and integrated monitoring of post-approval benefit-risk of vaccines, including a code of conduct and governance principles for collaborative studies...
March 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28283990/cerenkov-luminescence-imaging-physics-principles-and-potential-applications-in-biomedical-sciences
#14
REVIEW
Esther Ciarrocchi, Nicola Belcari
Cerenkov luminescence imaging (CLI) is a novel imaging modality to study charged particles with optical methods by detecting the Cerenkov luminescence produced in tissue. This paper first describes the physical processes that govern the production and transport in tissue of Cerenkov luminescence. The detectors used for CLI and their most relevant specifications to optimize the acquisition of the Cerenkov signal are then presented, and CLI is compared with the other optical imaging modalities sharing the same data acquisition and processing methods...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28283786/we-strongly-support-childhood-immunisation-statement-from-the-european-academy-of-paediatrics-eap
#15
Hans Juergen Dornbusch, Adamos Hadjipanayis, Stefano Del Torso, Jean-Christophe Mercier, Corinne Wyder, Lenneke Schrier, Robert Ross-Russell, Tom Stiris, Jonas F Ludvigsson
The eradication of smallpox and the elimination of several other infectious diseases from much of the world has provided convincing evidence that vaccines are among the most effective interventions for promoting health. The current scepticism about immunisation among members of the new US administration carries a risk of decreasing immunisation rates also in Europe. While only a small minority of the population are strongly anti-vaccine, their public activities have significantly influenced an uncertainty among the general population about both the safety of and the necessity for vaccination...
March 10, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28283121/health-care-expenditures-associated-with-pollution-exploratory-methods-and-findings
#16
Alexander S Preker, Olusoji O Adeyi, Marisa Gil Lapetra, Diane-Charlotte Simon, Eric Keuffel
BACKGROUND: The research done for this paper is part of the background analysis undertaken to support the work of the Global Commission on Pollution, Health and Development, an initiative of The Lancet, the Global Alliance on Health and Pollution, and the Icahn School of Medicine at Mount Sinai. The paper expands on areas where the current literature has gaps in knowledge related to the health care cost of pollution. OBJECTIVES: This study aims to generate an initial estimate of total tangible health care expenditure attributable to man-made pollution affecting air, soil and water...
September 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28281877/comprehensive-analysis-of-interaction-networks-of-telomerase-reverse-transcriptase-with-multiple-bioinformatic-approach-deep-mining-the-potential-functions-of-telomere-and-telomerase
#17
Chunyu Hou, Fei Wang, Xuewen Liu, Guangming Chang, Feng Wang, Xin Geng
Telomerase reverse transcriptase (TERT)is the protein component of telomerase complex. Evidence has accumulated showing that the non-telomeric functions of TERT are independent of telomere elongation. However, the mechanisms governing the interaction between TERT and its target genes are not revealed clear. The biological functions of TERT are not fully elucidated and have thus far been underestimated. To further explore these functions, we investigated TERT interaction networks using multiple bioinformatic databases, including BioGRID, STRING, DAVID, GeneCards, GeneMANIA, PANTHER, miRWalk, mirTarBase, miRNet, miRDB and TargetScan...
March 6, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28280742/main-reasons-for-registration-application-refusal-of-generic-and-similar-pharmaceutical-drug-products-by-the-brazilian-health-regulatory-agency-anvisa
#18
Ana Cerúlia Moraes do Carmo, Stefânia Schimaneski Piras, Nayrton Flávio Moura Rocha, Tais Gratieri
Objective. The marketing authorization of generic and similar pharmaceutical drug products involves the analysis of proposing company's administrative aspects as well as drug product technical description and scientific evaluations. This study evaluated the main reasons for registration refusal of generic and similar pharmaceutical drug products in Brazil. The aim is to help future applicants to better organize the proposal. Methods. A retrospective search of drug products registration processes was performed on the Brazilian Government Official Gazette from January 1, 2015, and December 31, 2015...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28277904/genome-wide-functional-analysis-in-candida-albicans
#19
Thabiso E Motaung, Ruan Ells, Carolina H Pohl, Jacobus Albertyn, Toi J Tsilo
Candida albicans is an important etiological agent of superficial and life-threatening infections in individuals with compromised immune systems. To date, we know of several overlapping genetic networks that govern virulence attributes in this fungal pathogen. Classical use of deletion mutants has led to the discovery of numerous virulence factors over the years, and genome-wide functional analysis has propelled gene discovery at an even faster pace. Indeed, a number of recent studies using large-scale genetic screens followed by genome-wide functional analysis has allowed for the unbiased discovery of many new genes involved in C...
February 8, 2017: Virulence
https://www.readbyqxmd.com/read/28277262/eliminating-blood-culture-false-positives-harnessing-the-power-of-nursing-shared-governance
#20
Dawn Moeller
Our emergency department struggled with unacceptable blood culture contamination rates for several years. The objective of this project was to create a self-governing culture within nursing that would generate and sustain the achievement of monthly blood culture contamination rates below the national benchmark of 3% and the hospital laboratory acceptable threshold of 2.3%. METHODS: The ED shared governance council partnered with the laboratory team to review the monthly epidemiology reports for all adult and pediatric ED patients having blood cultures performed from January 2010 through December 2015...
October 26, 2016: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
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