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https://www.readbyqxmd.com/read/29141505/serum-zinc-copper-and-iron-status-of-children-with-coeliac-disease-on-three-months-of-gluten-free-diet-with-or-without-four-weeks-of-zinc-supplements-a-randomised-controlled-trial
#1
K Negi, R Kumar, L Sharma, S P Datta, M Choudhury, P Kumar
Data about the effect of zinc supplementation with gluten-free diet on normalisation of plasma zinc, copper and iron in patients with coeliac disease are scanty. We evaluated the effect of zinc supplementation on serum zinc, copper and iron levels in patients with coeliac disease, by randomising 71 children newly diagnosed with coeliac disease into two groups: Group A = gluten-free diet (GFD); and Group B = gluten-free diet with zinc supplements (GFD +Zn). The rise in iron and zinc was significantly higher in the latter, but the mean rise of copper levels was slightly higher in the former, but the difference was not significant...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/29139480/position-paper-the-potential-role-of-optical-biopsy-in-the-study-and-diagnosis-of-environmental-enteric-dysfunction
#2
REVIEW
Alex J Thompson, Michael Hughes, Salzitsa Anastasova, Laurie S Conklin, Tudor Thomas, Cadman Leggett, William A Faubion, Thomas J Miller, Peter Delaney, François Lacombe, Sacha Loiseau, Alexander Meining, Rebecca Richards-Kortum, Guillermo J Tearney, Paul Kelly, Guang-Zhong Yang
Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology...
November 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29136140/inaccurate-aortic-stent-graft-deployment-in-the-distal-landing-zone-incidence-reasons-and-consequences
#3
Mikolaj Berezowski, Julia Morlock, Friedhelm Beyersdorf, Marek Jasinski, Tomasz Plonek, Matthias Siepe, Martin Czerny, Bartosz Rylski
OBJECTIVES: The aim of this study was to investigate the accuracy of stent graft deployment in the distal landing zone (LZ) during thoracic endovascular aortic repair (TEVAR). Currently, TEVAR focuses on accurate stent graft deployment in the proximal LZ. Data on landing in the distal LZ are lacking. METHODS: Of 195 TEVAR patients (2005-16) with a non-dissected aortic pathology, 59 [median age 73 years (first quartile 68; third quartile 77), 20 women] patients had a distal LZ shorter than 40 mm...
November 9, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29133321/can-physical-assessment-techniques-aid-diagnosis-in-people-with-chronic-fatigue-syndrome-myalgic-encephalomyelitis-a-diagnostic-accuracy-study
#4
Lucy Hives, Alice Bradley, Jim Richards, Chris Sutton, James Selfe, Bhaskar Basu, Kerry Maguire, Gail Sumner, Tarek Gaber, Annice Mukherjee, Raymond N Perrin
OBJECTIVE: To assess five physical signs to see whether they can assist in the screening of patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and potentially lead to quicker treatment. METHODS: This was a diagnostic accuracy study with inter-rater agreement assessment. Participants recruited from two National Health Service hospitals, local CFS/ME support groups and the community were examined by three practitioners on the same day in a randomised order...
November 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/29127130/eosinophilic-oesophagitis-and-coeliac-disease-is-there-an-association
#5
Ana Margarida Vaz, Antonio Jesus Cadilla, Diamantino Sousa, Horácio Guerreiro
A 25-year-old man was seen in outpatient clinic for progressive solid food dysphagia. He was already medicated with a proton pump inhibitor with no improvement. His blood tests showed a slight microcytic anaemia and peripheral eosinophilia. The oesophago-gastro-duodenoscopy showed longitudinal furrows in the distal two-thirds of the oesophagus and a concentric distal stenosis. The biopsies taken showed eosinophilic infiltrates consistent with eosinophilic oesophagitis. There was no improvement with topical fluticasone, so the patient was started on a systemic corticosteroid with resolution of dysphagia and of the oesophageal stenosis...
November 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29118688/a-tale-of-two-lymphomas
#6
Vikrant Parihar, Paul Crotty, Deidre McNamara
We present a patient with coeliac disease who developed refractory coeliac disease II, which was complicated by the development of metachronous lymphomas.
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29114847/intestinal-anti-transglutaminase2-iga-deposits-in-children-at-risk-for-coeliac-disease-data-from-the-prevent-cd-study
#7
Melissa Borrelli, Mariantonia Maglio, Ilma R Korponay-Szabó, Viktória Vass, M Luisa Mearin, Caroline Meijer, Hagit Niv-Drori, Carmen Ribes-Koninckx, María Roca, Raanan Shamir, Riccardo Troncone, Renata Auricchio
In Coeliac Disease (CD) anti-tissue transglutaminase2 IgA antibodies(anti-TG2) are produced and deposited in the intestine. PreventCD (www.preventcd.com) is a European multicenter study, which studies the influence of infant nutrition, and that of genetic, immunologic and other environmental factors, on the risk of developing CD. The aim of the current study was to evaluate in very early intestinal biopsies from at-risk infants the appearance of intestinal anti-TG2 deposits and their predictive value for villous atrophy...
November 8, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29113008/-drug-therapy-in-coeliac-disease-from-bench-to-bedside
#8
Jürgen Stein, Jörg-Dieter Schulzke, Detlef Schuppan
Coeliac disease is one of the most common diseases worldwide, with an estimated global prevalence of 0.5 - 1 %. The disease is triggered by a combination of environmental (gluten proteins from wheat, rye or barley) and genetic factors (mainly the human leucocyte antigens HLA-DQ2 or -DQ8). At present, a strict gluten-free diet (GFD) represents the only treatment option. However, strict adherence to a GFD is challenging, since even highly motivated patients may be subject to inadvertent or background exposure to gluten...
November 7, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29105146/the-effect-of-the-gluten-free-diet-on-cardiovascular-risk-factors-in-patients-with-coeliac-disease-a-systematic-review
#9
M D E Potter, S C Brienesse, M M Walker, A Boyle, N J Talley
INTRODUCTION: A gluten free diet (GFD), the mainstay of treatment for celiac disease, is being increasingly adopted by people without this condition. The long-term health effects of this diet, apart from its beneficial effect on enteropathy in celiac disease, are unclear. Concerns exist that the GFD may result in micronutrient deficiencies, increased exposure to toxins such as arsenic, and an increased cardiovascular risk. This systematic review addresses the effect of the GFD on several modifiable cardiovascular risk factors...
November 4, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29099090/a-new-proposal-for-the-pathogenic-mechanism-of-non-coeliac-non-allergic-gluten-wheat-sensitivity-piecing-together-the-puzzle-of-recent-scientific-evidence
#10
REVIEW
Valentina Leccioli, Mara Oliveri, Marcello Romeo, Massimiliano Berretta, Paola Rossi
Non-coeliac/non-allergic gluten/wheat sensitivity (NCG/WS) is a gluten-related disorder, the pathogenesis of which remains unclear. Recently, the involvement of an increased intestinal permeability has been recognized in the onset of this clinical condition. However, mechanisms through which it takes place are still unclear. In this review, we attempt to uncover these mechanisms by providing, for the first time, an integrated vision of recent scientific literature, resulting in a new hypothesis about the pathogenic mechanisms involved in NCG/WS...
November 2, 2017: Nutrients
https://www.readbyqxmd.com/read/29098163/changes-in-somatostatin-like-immunoreactivity-in-the-sympathetic-neurons-projecting-to-the-prepyloric-area-of-the-porcine-stomach-induced-by-selected-pathological-conditions
#11
Katarzyna Palus, Michał Bulc, Jarosław Całka
The aim of the present study was to define changes in the expression of somatostatin (SOM) in the sympathetic perikarya innervating the porcine stomach prepyloric area during acetylsalicylic-acid-induced gastritis (ASA) and experimentally induced hyperacidity (HCL) and following partial stomach resection (RES). On day 1, the stomachs were injected with neuronal retrograde tracer Fast Blue (FB). Animals in the ASA group were given acetylsalicylic acid orally for 21 days. On the 22nd day after FB injection, partial stomach resection was performed in RES animals...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29090036/the-autoimmunity-s-footprint-in-pediatrics-type-1-diabetes-coeliac-disease-thyroiditis
#12
Anca Orzan, Carmen Novac, Mihaela Mihu, Constantin Ionescu Tirgoviste, Mihaela Balgradean
The present case report aims to describe and discuss the approach for the management of difficult endotracheal intubation in an adult with Down syndrome undergoing cataract surgery. A 26-year-old female with Down syndrome and a validated diagnosis of cataract requiring surgery was examined in order to assess the degree of difficulty of endotracheal intubation. Patients with Down syndrome have characteristic craniofacial abnormalities which require a thorough pre-operative assessment to anticipate and prepare for a difficult endotracheal intubation...
June 2017: Mædica
https://www.readbyqxmd.com/read/29089264/transglutaminase-6-antibodies-are-not-yet-mainstream-in-neuro-coeliac-disease
#13
Chris J J Mulder, Maxine D Rouvroye, Anne-Marie van Dam
No abstract text is available yet for this article.
October 13, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29082741/point-of-care-testing-for-paediatric-coeliac-disease-in-the-new-espghan-era
#14
Michelle Shui Yee Lau, David S Sanders
One of the challenges in coeliac disease is the significant under-diagnosis despite the increasing prevalence and international guidelines for serological screening in appropriate patient cohorts. Several point-of-care tests for coeliac disease have been developed over the past decade with the aim of improving case detection using rapid and convenient testing. Most point-of-care tests, such as Biocard, detect anti-tissue transglutaminase (tTG) IgA antibodies, whereas Simtomax uniquely detects anti-deamidated gliadin peptide (DGP) IgA/IgG antibodies...
November 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29067147/collagenous-panenteritis-a-rare-cause-of-chronic-diarrhoea
#15
Sandev Singh, Larry Ee Juan Loo, Christopher Watters, Suhail Ahmed
Collagenous panenteritis is a rare inflammatory condition that causes profound diarrhoea and weight loss. There has only been a handful of cases reported in the literature. We report this rare case and the diagnostic difficulties encountered in securing the diagnosis. A 59-year-old woman presented with an 8-month history of diarrhoea and weight loss on a background of a family history of coeliac disease. Her presentation was complicated with acute kidney injury secondary to prerenal losses. Repeated gastroscopies and colonoscopies along with biopsies were inconclusive...
October 2017: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29061632/neoadjuvant-s-1-with-concurrent-radiotherapy-followed-by-surgery-for-borderline-resectable-pancreatic-cancer-study-protocol-for-an-open-label-multicentre-prospective-phase-ii-trial-jaspac05
#16
Shinichiro Takahashi, Izumi Ohno, Masafumi Ikeda, Tatsushi Kobayashi, Tetsuo Akimoto, Motohiro Kojima, Masaru Konishi, Katsuhiko Uesaka
INTRODUCTION: Borderline resectable pancreatic cancer (BRPC) can involve the portal vein, superior mesenteric vein, superior mesenteric artery, coeliac axis or hepatic artery, and has a high probability of positive surgical margins and poor prognosis after resection. Neoadjuvant chemoradiation is expected to provide substantial local control and prolong survival in patients with BRPC. METHODS AND ANALYSIS: This open-label, multicentre, prospective phase II trial will assess S-1 with concurrent radiotherapy as preoperative treatment for BRPC...
October 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29054322/intestinal-perforation-secondary-to-intestinal-diffuse-large-b-cell-lymphoma-in-a-patient-with-coeliac-disease
#17
Raquel Ríos León, Laura Crespo Pérez, Carla Martínez-Geijo Román, Ana Barbado Cano, Mónica García-Cosío Piqueras, Eugenia Sánchez Rodríguez, Irene García de la Filia Molina, Álvaro Flores de Miguel, Antonio Guerrero García, Francisco Javier López-Jiménez, Antonio Mena Mateos, Agustín Albillos Martínez
No abstract text is available yet for this article.
October 17, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29050807/the-relationship-between-gluten-free-diet-adherence-and-depressive-symptoms-in-adults-with-coeliac-disease-a-systematic-review-with-meta-analysis
#18
REVIEW
Kirby Sainsbury, Marta M Marques
PURPOSE: Depressive symptoms are common in patients with coeliac disease (CD) and may represent a barrier to gluten free diet (GFD) adherence. The aims of this meta-analysis were: (1) to synthesise the evidence on the relationship between depression or depressive symptoms and degree of adherence to a GFD in patients with CD who are already attempting a GFD (i.e., post-diagnosis and onset of GFD), and (2) to summarise the direction of causation of any observed relationship. METHODS: A random effects meta-analysis of 8 cross-sectional studies (N = 1644) was conducted...
January 1, 2018: Appetite
https://www.readbyqxmd.com/read/29048096/diagnostic-delay-in-dermatitis-herpetiformis-in-a-high-prevalence-area
#19
Eriika Mansikka, Teea Salmi, Katri Kaukinen, Pekka Collin, Heini Huhtala, Timo Reunala, Kaisa Hervonen
Dermatitis herpetiformis (DH) is an extra-intestinal manifestation of coeliac disease. The highest currently reported prevalence of DH is in Finland, but knowledge of diagnostic delay is limited. This study investigated the duration of rash prior to diagnosis in 446 patients with DH, analysing the results in 3 periods of 15 years. The diagnosis was considered delayed when the duration of rash before diagnosis was 2 years or longer. Factors associated with delayed diagnosis were analysed. Within the 45 years, the median duration of rash before diagnosis decreased significantly, from 12...
October 19, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29047268/liquid-chromatography-mass-spectrometry-analysis-reveals-hydrolyzed-gluten-in-beers-crafted-to-remove-gluten
#20
Michelle L Colgrave, Keren Byrne, Crispin A Howitt
During brewing, gluten proteins may be solubilized, modified, complexed, hydrolyzed, and/or precipitate. Gluten fragments that persist in conventional beers render them unsuitable for people with celiac disease (CD) or gluten intolerance. Barley-based beers crafted to remove gluten using proprietary precipitation and/or application of enzymes, e.g. prolyl endopeptidases (PEP) that degrade the proline-rich gluten molecules, are available commercially. Gluten measurement in fermented products remains controversial...
October 30, 2017: Journal of Agricultural and Food Chemistry
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