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https://www.readbyqxmd.com/read/28532727/experiences-and-own-management-regarding-residual-symptoms-among-people-with-coeliac-disease
#1
Lisa Ring Jacobsson, Anna Milberg, Katarina Hjelm, Maria Friedrichsen
CONTEXT: Between 7% and 30% of people with treated coeliac disease suffer from residual symptoms, and there is a knowledge gap about their own management of these symptoms. AIM: To explore experiences and management concerning residual symptoms despite a gluten-free diet in people with coeliac disease. METHODS: A qualitative explorative design with semi-structured interviews with 22 adults with coeliac disease in Sweden. Data were analysed using qualitative content analysis...
June 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28512643/diagnostic-and-research-aspects-of-small-intestinal-disaccharidases-in-coeliac-disease
#2
REVIEW
Tanja Šuligoj, Paul J Ciclitira, Borut Božič
Disaccharidases (DS) are brush border enzymes embedded in the microvillous membrane of small intestinal enterocytes. In untreated coeliac disease (CD), a general decrease of DS activities is seen. This manuscript reviews different aspects of DS activities in CD: their utility in the diagnosis and their application to in vitro toxicity testing. The latter has never been established in CD research. However, with the recent advances in small intestinal organoid techniques, DS might be employed as a biomarker for in vitro studies...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28511881/-what-medication-should-be-prescribed-to-a-patient-with-coeliac-disease
#3
C Pérez-Diez, S Guillén-Lorente, P Palomo-Palomo
Coeliac disease is a permanent intolerance to gluten proteins from wheat, rye, barley and triticale. Although strict adherence is complicated, the only effective treatment is a gluten-free diet throughout life. Some drugs contain starch as an excipient, and there is a risk related to the gluten content, which must be avoided in these patients. Current legislation requires the analysis of the protein content of wheat starch, or the absence of starches from another source where rice, maize, or potato starches are used as excipients...
May 13, 2017: Semergen
https://www.readbyqxmd.com/read/28511837/immunomodulatory-activity-of-recombinant-%C3%AE-gliadin-conjugated-to-cholera-toxin-in-dq8-transgenic-mice
#4
Stefano Rossi, Diomira Luongo, Francesco Maurano, Paolo Bergamo, Mauro Rossi
Coeliac disease (CD) is characterized by an intestinal lesion sustained by an abnormal mucosal T-cell response to wheat gliadin. An immunological approach that is able to suppress this immune response is a perspective worth pursuing. Several strategies of antigen administration have been aimed at the downregulation of pathogenic T-cells. In particular, we previously reported a significant suppression of the systemic cell-mediated response toward wheat gliadin in DQ8 transgenic mice receiving nasally a recombinant α-gliadin...
May 13, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28511171/clinical-outcome-of-patients-with-raised-intraepithelial-lymphocytes-with-normal-villous-architecture-on-duodenal-biopsy
#5
Vikrant Parihar, Roisin Stack, Alaa Alakkari, Nial Breslin, B M Ryan, Stephen Crowther, Deidre McNamara
INTRODUCTION: The finding of a raised intraepithelial lymphocytes (IELs) count with normal villous architecture is of sufficient clinical importance to be reported in routine duodenal biopsies. AIM: To study the clinical and demographic data of patients with isolated increased IELs on duodenal biopsy. METHODS: A single-tertiary-centre retrospective study was carried out with a review of medical records of patients with increased IELs. Patients from 2012 to 2014, >18 years with at least one biopsy from the second part of the duodenum with increased IELs; defined as >25 IELs/100 enterocytes, with preserved villous architecture were identified from our histopathology database with exclusion of patients with coeliac disease (CD)...
May 17, 2017: Digestion
https://www.readbyqxmd.com/read/28506538/epitope-specific-immunotherapy-targeting-cd4-positive-t-cells-in-coeliac-disease-two-randomised-double-blind-placebo-controlled-phase-1-studies
#6
Gautam Goel, Tim King, A James Daveson, Jane M Andrews, Janakan Krishnarajah, Richard Krause, Gregor J E Brown, Ronald Fogel, Charles F Barish, Roger Epstein, Timothy P Kinney, Philip B Miner, Jason A Tye-Din, Adam Girardin, Juha Taavela, Alina Popp, John Sidney, Markku Mäki, Kaela E Goldstein, Patrick H Griffin, Suyue Wang, John L Dzuris, Leslie J Williams, Alessandro Sette, Ramnik J Xavier, Ludvig M Sollid, Bana Jabri, Robert P Anderson
BACKGROUND: A gluten-free diet is the only means to manage coeliac disease, a permanent immune intolerance to gluten. We developed a therapeutic vaccine, Nexvax2, designed to treat coeliac disease. Nexvax2 is an adjuvant-free mix of three peptides that include immunodominant epitopes for gluten-specific CD4-positive T cells. The vaccine is intended to engage and render gluten-specific CD4-positive T cells unresponsive to further antigenic stimulation. We assessed the safety and pharmacodynamics of the vaccine in patients with coeliac disease on a gluten-free diet...
May 11, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28506537/epitope-specific-immunotherapy-a-vaccine-for-coeliac-disease
#7
Antonio Di Sabatino, Gino Roberto Corazza
No abstract text is available yet for this article.
May 11, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28493483/preoperative-imaging-and-prediction-of-oesophageal-conduit-necrosis-after-oesophagectomy-for-cancer
#8
P Lainas, D Fuks, S Gaujoux, Z Machroub, A Fregeville, T Perniceni, F Mal, B Dousset, B Gayet
BACKGROUND: Oesophageal conduit necrosis following oesophagectomy is a rare but life-threatening complication. The present study aimed to assess the impact of coeliac axis stenosis on outcomes after oesophagectomy for cancer. METHODS: The study included consecutive patients who had an Ivor Lewis procedure with curative intent for middle- and lower-third oesophageal cancer at two tertiary referral centres. All patients underwent preoperative multidetector CT with arterial phase to detect coeliac axis stenosis...
May 11, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28484520/significantly-higher-faecal-counts-of-the-yeasts-candida-and-saccharomyces-identified-in-people-with-coeliac-disease
#9
Joanna Harnett, Stephen P Myers, Margaret Rolfe
BACKGROUND: Coeliac disease is an autoimmune disorder resulting from an interaction between diet, genome and immunity. The treatment of CoeD is lifelong adherence to a gluten free diet, which is associated with clinical and histological improvements. However, a substantive number of individuals report only partial symptom improvement despite both compliance with a strict gluten free diet and improvements in serological and histological biomarkers of disease activity. The role of the intestinal microbiota is an area of interest in this sub-group...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28483757/barriers-to-implementing-the-revised-espghan-guidelines-for-coeliac-disease-in-children-a-cross-sectional-survey-of-coeliac-screen-reporting-in-laboratories-in-england
#10
Siba Prosad Paul, Sophie Louise Harries, Dharamveer Basude
BACKGROUND: European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guidelines for diagnosing paediatric coeliac disease (CD) were revised in 2012. This enabled serological diagnosis in a selective group of symptomatic children using anti-tissue transglutaminase (anti-tTG) titre, antiendomysial antibodies (EMA) and HLA DQ2/DQ8 status. However, observing variations in the availability of serological tests for CD within our region, we conducted a countrywide survey to explore the diversity of these tests for all paediatric centres...
May 8, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28474831/editorial-risk-factors-for-persistent-villus-atrophy-in-coeliac-disease-is-it-time-to-reconsider-definitions-for-refractory-coeliac-disease-authors-reply
#11
EDITORIAL
S Mahadev, J A Murray, P H R Green, D A Adelman, B Lebwohl
No abstract text is available yet for this article.
June 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28474827/editorial-risk-factors-for-persistent-villus-atrophy-in-coeliac-disease-is-it-time-to-reconsider-definitions-for-refractory-coeliac-disease
#12
EDITORIAL
M R H Braude, E D Newnham
No abstract text is available yet for this article.
June 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28466499/implementation-of-national-institute-for-health-and-care-excellence-nice-guidance-to-measure-iga-with-all-coeliac-screens-can-an-affordable-solution-be-devised
#13
Dylan James Mac Lochlainn, Ravina Hira-Kazal, Helen Varney, John Maher
There has been a dramatic increase in requests for coeliac disease (CD) serological screening using IgA tissue transglutaminase antibodies (IgA-tTG). Recently, the UK National Institute for Health and Care Excellence has revised its guidance, recommending that total IgA should also be measured in all samples. This is justified since false negative results may occur with IgA deficiency. However, implementation of this guidance will incur considerable expense. Tests that measure IgA-tTG antibodies can detect IgA deficiency, indicated by low background signal...
May 2, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28465547/coeliac-disease-a-viral-trigger-of-food-insensitivity-and-coeliac-disease
#14
Katrina Ray
No abstract text is available yet for this article.
June 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28462569/exercise-induced-median-arcuate-ligament-syndrome-in-athletes-case-series
#15
Yasmin Grant, Sarah Onida, Brahman Dharmarajah, Emma B Davies, Alun H Davies
The median arcuate ligament (MAL) is a fibrous arch connecting the right and left diaphragmatic crura; this usually lies superior to the origin of the coeliac axis. Occasionally, the ligament crosses anterior to the aorta, at the level of the coeliac trunk; leading to mechanical compression of the coeliac artery, resulting in the clinical condition of MAL syndrome (MALS). Symptomatic patients characteristically present with post-prandial pain associated with unintentional weight loss, nausea, vomiting and diarrhoea...
April 28, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28457172/a-systematic-surgical-approach-to-hepatoblastoma-with-intracardiac-extension
#16
Sajid Sayed, Sudesh Prabhu, Jonathan Fawcett, Kelvin Choo, Nelson Alphonso
Hepatoblastoma is very uncommon in children, and intracardiac extension is rare. The SIOPEL-4 regime for metastatic hepatoblastoma has extended the surgical options with good results. We successfully treated a boy aged 2 years and 9 months with hepatoblastoma, using a multidisciplinary surgical strategy involving an extended left hepatectomy, left adrenalectomy, biopsy of the paraaortic and coeliac lymph nodes, and resection of the inferior vena caval-right atrial extension of the hepatoblastoma, under cardiopulmonary bypass and deep hypothermia...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28452813/duodenal-histopathology-and-laboratory-deficiencies-related-to-bone-metabolism-in-coeliac-disease
#17
Lotte Posthumus, Abdul Al-Toma
OBJECTIVES: Coeliac disease (CD) is a chronic immune-mediated small intestine enteropathy precipitated by gluten in genetically predisposed individuals. Adult presentation is often atypical and malabsorption of vitamins and minerals is common, with a consequent disturbance of bone metabolism. We aim to evaluate laboratory deficiencies related to bone metabolism and the relationship between severity of histological damage and degree of bone mass loss at diagnosis of CD. MATERIALS AND METHODS: A retrospective cross-sectional study of 176 adult coeliac patients was carried out...
April 27, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28446485/primary-aortojejunal-fistula-a-rare-cause-for-massive-upper-gastrointestinal-bleeding
#18
Sylvester Paulasir, Rhami Khorfan, Christina Harsant, Harry Linne Anderson
A 68-year-old man presented to the emergency department with haematemesis and shock. Upper endoscopy and selective angiography could not identify the source of bleeding. He underwent selective embolisation of the gastroduodenal artery. The patient then had a period of about 24 hours with relative haemodynamic stability before having another episode of massive upper gastrointestinal bleed. A second attempt to embolise the common hepatic artery and distal coeliac axis was unsuccessful. Hence, he was urgently taken to the operating room for exploratory laparotomy...
April 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28441689/coeliac-disease-further-evidence-that-biopsy-is-not-always-necessary-for-diagnosis
#19
Geoffrey K T Holmes, Julia M Forsyth, Sarah Knowles, Helen Seddon, Peter G Hill, Andrew S Austin
OBJECTIVES: Growing evidence supports the view that the diagnosis of coeliac disease (CD) can be made by serological tests alone, although this approach is still not widely accepted. We previously showed in retrospective and prospective studies that in adults an IgA-tissue transglutaminase antibody cut-off can be defined above which the positive predictive value for CD is 100%. Following a change in the analytical method for measuring the antibody, our objectives were to re-examine this finding in a larger series of adults to ascertain whether a diagnosis of CD can be reliably made in a proportion of patients without the need for small bowel biopsy and to re-evaluate the diagnostic guidelines used in our centre...
June 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28429033/clinics-in-diagnostic-imaging-176-acute-embolic-occlusion-of-the-coeliac-artery
#20
Chinthaka Appuhamy, Justin Kwan, Martin Weng Chin H'ng, Sriram Narayanan, Sundeep Punamiya
A 52-year-old man, who had a background of chronic heart disease and atrial fibrillation, as well as non-compliance with warfarin therapy, presented with a two-week history of worsening upper abdominal pain. Computed tomography mesenteric angiography showed complete embolic occlusion of the coeliac artery with resultant segmental splenic infarction, and thrombus within the left ventricle. A decision was made to proceed with catheter-directed thrombolysis. Subsequent follow-up angiogram at 12 hours showed successful treatment with complete dissolution of the coeliac embolus...
April 2017: Singapore Medical Journal
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