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Resveratrol AND thyroidism

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https://www.readbyqxmd.com/read/28759712/mechanisms-of-action-of-nonpeptide-hormones-on-resveratrol-induced-antiproliferation-of-cancer-cells
#1
REVIEW
Hung-Yun Lin, Meng-Ti Hsieh, Guei-Yun Cheng, Hsuan-Yu Lai, Yu-Tang Chin, Ya-Jung Shih, André Wendindondé Nana, Shin-Ying Lin, Yu-Chen S H Yang, Heng-Yuan Tang, I-Jen Chiang, Kuan Wang
Nonpeptide hormones, such as thyroid hormone, dihydrotestosterone, and estrogen, have been shown to stimulate cancer proliferation via different mechanisms. Aside from their cytosolic or membrane-bound receptors, there are receptors on integrin αv β3 for nonpeptide hormones. Interaction between hormones and integrin αv β3 can induce signal transduction and eventually stimulate cancer cell proliferation. Resveratrol induces inducible COX-2-dependent antiproliferation via integrin αv β3 . Resveratrol and hormone-induced signals are both transduced by activated extracellular-regulated kinases 1 and 2 (ERK1/2); however, hormones promote cell proliferation, while resveratrol induces antiproliferation in cancer cells...
July 31, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28677796/resveratrol-suppresses-thyroid-hormone%C3%A2-induced-osteocalcin-synthesis-in-osteoblasts
#2
Kazuhiko Fujita, Haruhiko Tokuda, Shingo Kainuma, Gen Kuroyanagi, Naohiro Yamamoto, Rie Matsushima-Nishiwaki, Atsushi Harada, Osamu Kozawa, Takanobu Otsuka
Resveratrol, a polyphenolic compound that is present in grape skins, berries and red wine, may be beneficial for human health through its anti‑inflammatory and anti‑oxidant effects. It has been previously demonstrated that resveratrol exerts its biological effects primarily via sirtuin 1 (SIRT1) activation. We previously reported that triiodothyronine (T3) induces osteocalcin synthesis in osteoblast‑like MC3T3‑E1 cells, and that p38 mitogen‑activated protein (MAP) kinase mediates the T3‑stimulated synthesis of osteocalcin...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28669347/evaluation-of-anti-cancer-activity-of-stilbene-and-methoxydibenzo-b-f-oxepin-derivatives
#3
Damian Garbicz, Damian Mielecki, Michał Wrzesiński, Tomasz Pilżys, Michał Marcinkowski, Jan Piwowarski, Janusz Dębski, Ewelina Palak, Przemysław Szczeciński, Hanna Krawczyk, Elżbieta Grzesiuk
BACKGROUND: Stilbenes, 1,2-diphenylethen derivatives, including resveratrol and combretastatins, show anticancer features especially against tumor angiogenesis. Fosbretabulin, CA-4, in combination with carboplatin, is in the last stages of clinical tests as an inhibitor of thyroid cancer. The mode of action of these compounds involves suppression of angiogenesis through interfering with tubulin (de)polymerization. OBJECTIVE: We have previously synthesized five E-2-hydroxystilbenes and seven dibenzo[b,f]oxepins in Z configuration, with methyl or nitro groups at varied positions...
June 23, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28668442/resveratrol-has-anti-thyroid-effects-both-in%C3%A2-vitro-and-in%C3%A2-vivo
#4
Cesidio Giuliani, Manuela Iezzi, Laura Ciolli, Alba Hysi, Ines Bucci, Serena Di Santo, Cosmo Rossi, Mirco Zucchelli, Giorgio Napolitano
Resveratrol is a natural polyphenol with antioxidant, anti-inflammatory, and antiproliferative properties. We have shown previously that resveratrol decreases sodium/iodide symporter expression and iodide uptake in thyrocytes, both in vitro and in vivo. In the present study, we further investigated the effects of resveratrol, with evaluation of the expression of additional thyroid-specific genes in the FRTL-5 rat thyroid cell line: thyroglobulin, thyroid peroxidase, TSH receptor, Nkx2-1, Foxe1 and Pax8. We observed decreased expression of these genes in FRTL-5 cells treated with 10 μM resveratrol...
September 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28617535/research-on-the-protective-effects-of-antioxidants-on-metabolic-syndrome-induced-by-thyroid-dysfunction
#5
Y Chen, Z Zhou, X-X Li, T Wang
OBJECTIVE: This paper researches on the protective effects of antioxidants on metabolic syndrome induced by thyroid dysfunction. While the role of Lipoic acid (LA), Resveratrol (R) and Quercetin (Q) are recognized, the mechanisms for their ameliorative effects are partially understood. Therefore, the objective of this study was to determine the prevalence of MS among university workers and to examine the relationship with thyroid function and mechanisms for protective effects of LA, Resveratrol and Quercetin on the heart, kidneys and lungs...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28388839/critical-depurinating-dna-adducts-estrogen-adducts-in-the-etiology-and-prevention-of-cancer-and-dopamine-adducts-in-the-etiology-and-prevention-of-parkinson-s-disease
#6
REVIEW
Ercole L Cavalieri, Eleanor G Rogan, Muhammad Zahid
Endogenous estrogens become carcinogens when dangerous metabolites, the catechol estrogen quinones, are formed. In particular, the catechol estrogen-3,4-quinones can react with DNA to produce an excess of specific depurinating estrogen-DNA adducts. Loss of these adducts leaves apurinic sites in the DNA, generating subsequent cancer-initiating mutations. Unbalanced estrogen metabolism yields excessive catechol estrogen-3,4-quinones, increasing formation of depurinating estrogen-DNA adducts and the risk of initiating cancer...
September 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28150875/atp2a3-gene-as-an-important-player-for-resveratrol-anticancer-activity-in-breast-cancer-cells
#7
Eduardo Izquierdo-Torres, Gabriela Rodríguez, Iván Meneses-Morales, Angel Zarain-Herzberg
The Ca(2+) -ATPases from the Sarco/endoplasmic reticulum (SERCA) are fundamental for maintaining intracellular [Ca(2+) ] homeostasis by pumping Ca(2+) into the endoplasmic reticulum (ER) of eukaryotic cells. SERCA enzymes are encoded by three different genes (ATP2A1-3), whose expression occurs in a tissue and development stage-specific manner. It has been reported alterations in the expression of SERCA2 and SERCA3 pumps in different types of cancer: oral, lung, colon, stomach, central nervous system, thyroid, breast, and prostate...
February 2, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28099124/browning-of-white-adipose-tissue-lessons-from-experimental-models
#8
Thereza Cristina Lonzetti Bargut, Vanessa Souza-Mello, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Beige or brite (brown-in-white) adipocytes are present in white adipose tissue (WAT) and have a white fat-like phenotype that when stimulated acquires a brown fat-like phenotype, leading to increased thermogenesis. This phenomenon is known as browning and is more likely to occur in subcutaneous fat depots. Browning involves the expression of many transcription factors, such as PR domain containing 16 (PRDM16) and peroxisome proliferator-activated receptor (PPAR)-γ, and of uncoupling protein (UCP)-1, which is the hallmark of thermogenesis...
January 18, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28001084/resveratrol-as-an-anticancer-agent-a-review
#9
Abdur Rauf, Muhammad Imran, Masood Sadiq Butt, Muhammad Nadeem, Dennis G Peters, Mohammad S Mubarak
Owing to their antimicrobial, antioxidant, and anti-inflammatory activity, grapes (Vitis vinifera L.) are the archetypal paradigms of fruits used not only for nutritional purposes but also for exclusive therapeutics. Grapes are a prominent and promising source of phytochemicals, especially resveratrol, a phytoalexin antioxidant found in red grapes which has both chemopreventive and therapeutic effects against various ailments. Resveratrol's role in reducing different human cancers, including breast, cervical, uterine, blood, kidney, liver, eye, bladder, thyroid, esophageal, prostate, brain, lung, skin, gastric, colon, head and neck, bone, ovarian, and cervical, has been reviewed...
December 21, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27260466/cardioprotective-effects-of-lipoic-acid-quercetin-and-resveratrol-on-oxidative-stress-related-to-thyroid-hormone-alterations-in-long-term-obesity
#10
Maureen Jepkorir Cheserek, Guirong Wu, Longnan Li, Lirong Li, Eric Karangwa, Yonghui Shi, Guowei Le
This study investigated possible mechanisms for cardioprotective effects of lipoic acid (LA), quercetin (Q) and resveratrol (R) on oxidative stress related to thyroid hormone alterations in long-term obesity. Female C57BL/6 mice were fed on high-fat diet (HFD), HFD+LA, HFD+R, HFD+Q and normal diet for 26weeks. Body weight, blood pressure, thyroid hormones, oxidative stress markers, angiotensin converting enzyme (ACE), nitric oxide synthase (NOS) and ion pump activities were measured, and expression of cardiac genes was analyzed by real-time polymerase chain reaction...
July 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27252679/resveratrol-ameliorates-the-anxiety-and-depression-like-behavior-of-subclinical-hypothyroidism-rat-possible-involvement-of-the-hpt-axis-hpa-axis-and-wnt-%C3%AE-catenin-pathway
#11
Jin-Fang Ge, Ya-Yun Xu, Gan Qin, Jiang-Qun Cheng, Fei-Hu Chen
Metabolic disease subclinical hypothyroidism (SCH) is closely associated with depression-like behavior both in human and animal studies, and our previous studies have identified the antidepressant effect of resveratrol (RES) in stressed rat model. The aim of this study was to investigate whether RES would manifest an antidepressant effect in SCH rat model and explore the possible mechanism. A SCH rat model was induced by hemi-thyroid electrocauterization, after which the model rats in the RES and LT4 groups received a daily intragastric injection of RES at the dose of 15 mg/kg or LT4 at the dose of 60 μg/kg for 16 days...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27180721/mixed-ligand-copper-ii-complexes-activate-aryl-hydrocarbon-receptor-ahr-and-induce-cyp1a-genes-expression-in-human-hepatocytes-and-human-cell-lines
#12
Kateřina Kubešová, Aneta Dořičáková, Zdeněk Trávníček, Zdeněk Dvořák
The effects of four copper(II) mixed-ligand complexes [Cu(qui1)(L)]NO3·H2O (1-3) and [Cu(qui2)(phen)]NO3 (4), where qui1=2-phenyl-3-hydroxy-4(1H)-quinolinone, Hqui2=2-(4-amino-3,5-dichlorophenyl)-N-propyl-3-hydroxy-4(1H)-quinolinone-7-carboxamide, L=1,10-phenanthroline (phen) (1), 5-methyl-1,10-phenanthroline (mphen) (2), bathophenanthroline (bphen) (3), on transcriptional activities of steroid receptors, nuclear receptors and xenoreceptors have been studied. The complexes (1-4) did not influence basal or ligand-inducible activities of glucocorticoid receptor, androgen receptor, thyroid receptor, pregnane X receptor and vitamin D receptor, as revealed by gene reporter assays...
July 25, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27060227/generation-of-novel-thyroid-cancer-stem-like-cell-clones-effects-of-resveratrol-and-valproic-acid
#13
Heather Hardin, Xiao-Min Yu, April D Harrison, Carolina Larrain, Ranran Zhang, Jidong Chen, Herbert Chen, Ricardo V Lloyd
Anaplastic thyroid cancer is an aggressive and highly lethal cancer for which conventional therapies have proved ineffective. Cancer stem-like cells (CSCs) represent a small fraction of cells in the cancer that are resistant to chemotherapy and radiation therapy and are responsible for tumor reoccurrence and metastasis. We characterized CSCs in thyroid carcinomas and generated clones of CSC lines. Our study showed that anaplastic thyroid cancers had significantly more CSCs than well-differentiated thyroid cancers...
June 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/26979321/depurinating-estrogen-dna-adducts-generators-of-cancer-initiation-their-minimization-leads-to-cancer-prevention
#14
REVIEW
Ercole L Cavalieri, Eleanor G Rogan
Estrogens can initiate cancer by reacting with DNA. Specific metabolites of endogenous estrogens, the catechol estrogen-3,4-quinones, react with DNA to form depurinating estrogen-DNA adducts. Loss of these adducts leaves apurinic sites in the DNA, generating mutations that can lead to the initiation of cancer. A variety of endogenous and exogenous factors can disrupt estrogen homeostasis, which is the normal balance between estrogen activating and protective enzymes. In fact, if estrogen metabolism becomes unbalanced and generates excessive catechol estrogen 3,4-quinones, formation of depurinating estrogen-DNA adducts increases and the risk of initiating cancer is greater...
March 2016: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/26959237/chemical-and-hormonal-effects-on-stat5b-dependent-sexual-dimorphism-of-the-liver-transcriptome
#15
Keiyu Oshida, David J Waxman, J Christopher Corton
The growth hormone (GH)-activated transcription factor signal transducer and activator of transcription 5b (STAT5b) is a key regulator of sexually dimorphic gene expression in the liver. Suppression of hepatic STAT5b signaling is associated with lipid metabolic dysfunction leading to steatosis and liver cancer. In the companion publication, a STAT5b biomarker gene set was identified and used in a rank-based test to predict both increases and decreases in liver STAT5b activation status/function with high (≥ 97%) accuracy...
2016: PloS One
https://www.readbyqxmd.com/read/26943153/pdgf-bb-enhances-the-proliferation-of-cells-in-human-orbital-fibroblasts-by-suppressing-pdcd4-expression-via-up-regulation-of-microrna-21
#16
Ji-Young Lee, Mihee Yun, Ji-Sun Paik, Seong-Beom Lee, Suk-Woo Yang
PURPOSE: The aim of this study was to investigate the effect of platelet-derived growth factor (PDGF)-BB on the proliferation of cells and its possible mechanism in human orbital fibroblasts. METHODS: Human orbital fibroblasts were obtained from orbital fat from decompression surgery in patients with thyroid-associated ophthalmopathy (TAO). The cells were treated with PDGF-BB, and the number of cells was counted using an Advanced Detection and Accurate Measurement (ADAM) automatic cell counter...
March 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26228795/resveratrol-improved-the-spatial-learning-and-memory-in-subclinical-hypothyroidism-rat-induced-by-hemi-thyroid-electrocauterization
#17
COMPARATIVE STUDY
Jin-Fang Ge, Ya-Yun Xu, Ning Li, Yue Zhang, Guo-Liang Qiu, Cheng-Hao Chu, Cai-Yun Wang, Gan Qin, Fei-Hu Chen
The major purpose of this study was to investigate the effect of resveratrol (RES) on the spatial learning and memory ability in subclinical hypothyroidism (SCH) rat model and the potential mechanism. A SCH rat model was induced by hemi-thyroid electrocauterization and the activity of hypothalamus-pituitary-thyroid (HPT) axis was detected. The spatial learning and memory ability was tested using Morris water maze (MWM) and Y-maze. The protein expressions of synaptotagmin-1 (syt-1) and brain-derived neurotrophic factor (BDNF) in the hippocampus were measured via western blot...
2015: Endocrine Journal
https://www.readbyqxmd.com/read/26041883/thyroid-hormone-and-anti-apoptosis-in-tumor-cells
#18
REVIEW
Hung-Yun Lin, Gennadi V Glinsky, Shaker A Mousa, Paul J Davis
The principal secretory product of the thyroid gland, L-thyroxine (T4), is anti-apoptotic at physiological concentrations in a number of cancer cell lines. Among the mechanisms of anti-apoptosis activated by the hormone are interference with the Ser-15 phosphorylation (activation) of p53 and with TNFα/Fas-induced apoptosis. The hormone also decreases cellular abundance and activation of proteolytic caspases and of BAX and causes increased expression of X-linked inhibitor of apoptosis (XIAP). The anti-apoptotic effects of thyroid hormone largely are initiated at a cell surface thyroid hormone receptor on the extracellular domain of integrin αvβ3 that is amply expressed and activated in cancer cells...
June 20, 2015: Oncotarget
https://www.readbyqxmd.com/read/25839994/regulation-of-alpha-1-acid-glycoprotein-synthesis-by-porcine-hepatocytes-in-monolayer-culture
#19
COMPARATIVE STUDY
T J Caperna, A E Shannon, M Stoll, L A Blomberg, T G Ramsay
Alpha-1 acid glycoprotein (AGP, orosomucoid, ORM-1) is a highly glycosylated mammalian acute-phase protein, which is synthesized primarily in the liver and represents the major serum protein in newborn pigs. Recent data have suggested that the pig is unique in that AGP is a negative acute-phase protein in this species, and its circulating concentration appears to be associated with growth rate. The purpose of the present study was to investigate the regulation of AGP synthesis in hepatocytes prepared from suckling piglets and to provide a framework to compare its regulation with that of haptoglobin (HP), a positive acute-phase protein...
July 2015: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/25276125/resveratrol-sensitizes-selectively-thyroid-cancer-cell-to-131-iodine-toxicity
#20
Seyed Jalal Hosseinimehr, Seyed Amir Hossein Hosseini
Background. In this study, the radiosensitizing effect of resveratrol as a natural product was investigated on cell toxicity induced by (131)I in thyroid cancer cell. Methods. Human thyroid cancer cell and human nonmalignant fibroblast cell (HFFF2) were treated with (131)I and/or resveratrol at different concentrations for 48 h. The cell proliferation was measured by determination of the percent of the survival cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results. Findings of this study show that resveratrol enhanced the cell death induced by (131)I on thyroid cancer cell...
2014: Journal of Toxicology
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