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https://www.readbyqxmd.com/read/29161804/importance-of-biological-ultrafine-particles-in-indoor-dust-as-a-pathogenesis-of-chronic-inflammatory-lung-diseases
#1
Young-Koo Jee, Jinho Yang, Yoon-Keun Kim, You-Young Kim, Tae Soo Kang
The role of infectious agents in the etiology of inflammatory diseases once believed to be non-infectious is increasingly being recognized. Many bacterial components in the indoor dust can evoke inflammatory lung diseases. Bacteria secrete nanometer-sized vesicles into the extracellular milieu, so-called extracellular vesicles (EVs). which are pathophysiologically related to inflammatory diseases. Microbiota compositions in the indoor dust revealed the presence of both gram-negative and gram-positive bacteria...
November 17, 2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/29161770/twin-models-of-environmental-and-genetic-influences-on-pubertal-development-salivary-testosterone-and-estradiol-in-adolescence
#2
Andrew D Grotzinger, Frank D Mann, Megan W Patterson, Kathrin Herzhoff, Jennifer L Tackett, Elliot M Tucker-Drob, K Paige Harden
OBJECTIVE: Research on sources of variation in adolescent's gonadal hormone levels is limited. We sought to decompose individual differences in adolescent testosterone, estradiol and pubertal status, into genetic and environmental components. DESIGN: A sample of male and female adolescent twins from the greater Austin and Houston areas provided salivary samples, with a subset of participants providing longitudinal data at two waves. PARTICIPANTS: The sample included 902 adolescent twins, 49% female, ages 13-20 years (M = 15...
November 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29161765/mir-335-inhibited-cell-proliferation-of-lung-cancer-cells-by-target-tra2%C3%AE
#3
Jian Liu, Tingting Bian, Jia Feng, Li Qian, Jianguo Zhang, Daishan Jiang, Qing Zhang, Xiaoli Li, Yifei Liu, Jiahai Shi
Accumulating evidence has suggested that the dysregulation of miRNAs is an important factor in the pathogenesis of lung cancer. Here, we demonstrate that miR-335 expression is reduced in non-small cell lung cancer (NSCLC) tumors relative to non-cancerous adjacent tissues, whilst the expression of Tra2β is increased. In addition, clinical data revealed that the increased Tra2β and decreased miR-335 expression observed in NSCLC cells was associated with poor patient survival rates. In-vitro experimentation showed that the overexpression of miR-335 inhibited the growth, invasion and migration capabilities of A459 lung cancer cells, by targeting Tra2β...
November 21, 2017: Cancer Science
https://www.readbyqxmd.com/read/29161761/pelvic-local-recurrence-from-colorectal-cancer-surgical-challenge-with-changing-preconditions
#4
Henrik Iversen, Anna Martling, Hemming Johansson, Per J Nilsson, Torbjörn Holm
AIM: Although the rate of local recurrence (LR) after colorectal cancer surgery has decreased, it still poses major surgical and oncological challenges. The aim of this study, based on an audit from a tertiary referral center, was to evaluate determinants associated with outcomes after surgery for pelvic LR and how these have changed over time. METHOD: Retrospective analysis of all resections for pelvic LR of colorectal cancer performed at the Karolinska University Hospital from January 2003 until August 2009 (period 1) and September 2009 until November 2013 (period 2)...
November 21, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29161757/impact-of-cyp3a5-genomic-variances-on-clinical-outcomes-among-african-american-kidney-transplant-recipients
#5
Tomefa E Asempa, Lorita M Rebellato, Suzanne Hudson, Kimberly Briley, Angela Q Maldonado
Little is known about the impact of CYP3A5 polymorphisms on transplantation outcomes among African-American (AA) kidney transplant recipients. To assess this issue, clinical outcomes were compared between AA CYP3A5*1 expressers versus non-expressers. This retrospective cohort study analyzed AA kidney transplant recipients. Biopsy-proven acute rejection (BPAR), delayed graft function (DGF), glomerular filtration rate (GFR), infections and tacrolimus dosing requirements were examined in 106 immunologically high-risk AA kidney transplant patients over a 2 year follow-up period...
November 21, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29161755/kv-1-channel-expression-and-vasomotor-function-in-human-coronary-resistance-arteries
#6
Yoshinori Nishijima, Ankush Korishettar, Dawid S Chabowski, Sheng Cao, Xiaodong Zheng, David D Gutterman, David X Zhang
OBJECTIVES: KV channels are important regulators of vascular tone, but the identity of specific KV channels involved and their regulation in disease remain less well understood. We determined the expression of KV 1 channel subunits and their role in cAMP-mediated dilation in coronary resistance arteries from subjects with and without coronary artery disease (CAD). METHODS: Human coronary arteries and arterioles (HCA) from non-CAD and CAD patients were assessed for mRNA and protein expression of KV 1 channel subunits with molecular techniques and for vasodilator response with isolated arterial myography...
November 21, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29161752/prenatal-megacystis-is-prediction-of-outcome-and-renal%C3%A2-function-possible
#7
Regina Tschannen, Rita Gobet, Josef Wisser
Objective To assess prenatal prognostic criteria for fetuses with megacystis in order to counsel parents. Methods In a retrospective observational study at a single tertiary referral center, we assessed the clinical course of 53 fetuses with megacystis cared for at the Department of Obstetrics of the University Hospital Zurich between 1995 and 2008 and followed them up for 2 to 12 years. We determined fetal karyotype, amniotic fluid volume and fetal urinary biochemistry as prenatal prognostic factors...
November 21, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29161689/interactive-effectiveness-of-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-or-their-combination-on-survival-of-hemodialysis-patients
#8
Ryo Kido, Tadao Akizawa, Masafumi Fukagawa, Yoshihiro Onishi, Takuhiro Yamaguchi, Shunichi Fukuhara
BACKGROUND: Does the use of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers individually or as a combination confer a survival benefit in hemodialysis patients? The answer to this question is yet unclear. METHODS: We performed a case-cohort study using data from the Mineral and Bone Disorder Outcomes Study for Japanese CKD stage 5D patients (MBD-5D), a 3-year multicenter prospective case-cohort study, including 8,229 hemodialysis patients registered from 86 facilities in Japan...
November 21, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/29161674/deep-brain-stimulation-of-the-subcallosal-cingulate-gyrus-in-patients-with-treatment-resistant-depression-a-double-blinded-randomized-controlled-study-and-long-term-follow-up-in-eight-patients
#9
Angela Merkl, Sabine Aust, Gerd-Helge Schneider, Veerle Visser-Vandewalle, Andreas Horn, Andrea A Kühn, Jens Kuhn, Malek Bajbouj
BACKGROUND: Deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG) is an experimental approach in treatment-resistant depression (TRD). Short-term results of efficacy in DBS are incongruent and studies investigating long-term effects are warranted. METHODS: We assessed efficacy of SCG-DBS in eight patients randomized into a delayed-onset group (sham-DBS four weeks) and a non-delayed-onset group. The primary outcome measure was improvement on the Hamilton Depression Rating-Scale (HAMD-24-item-version)...
November 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29161671/effective-removal-of-hazardous-trace-metals-from-recovery-boiler-fly-ashes
#10
Teemu Kinnarinen, Mohammad Golmaei, Eeva Jernström, Antti Häkkinen
The objective of this study is to introduce a treatment sequence enabling straightforward and effective recovery of hazardous trace elements from recovery boiler fly ash (RBFA) by a novel method, and to demonstrate the subsequent removal of Cl and K with the existing crystallization technology. The treatment sequence comprises two stages: dissolution of most other RBFA components than the hazardous trace elements in water in Step 1 of the treatment, and crystallization of the process chemicals in Step 2. Solid-liquid separation has an important role in the treatment, due to the need to separate first the small solid residue containing the trace elements, and to separate the valuable crystals, containing Na and S, from the liquid rich in Cl and K...
November 18, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29161668/patterns-of-c-reactive-protein-ratio-response-to-antibiotics-in-pediatric-sepsis-a-prospective-cohort-study
#11
Vanessa Soares Lanziotti, Pedro Póvoa, Arnaldo Prata-Barbosa, Lucas Berbet Pulcheri, Ligia S C F Rabello, José Roberto Lapa E Silva, Marcio Soares, Jorge I F Salluh
PURPOSE: Evaluate sequential C-reactive protein (CRP) measurements and patterns of CRP-ratio response to antibiotic therapy during first 7days in Pediatric Intensive Care Unit (PICU) of septic children. METHODS: Prospective, cohort study of children (1month-12years) admitted at 3 PICUs, with diagnosis of sepsis with <72h course. CRP-ratio was calculated in relation to D0_CRP value. Children were classified according to an individual pattern of CRP-ratio response: fast - CRP_D4 of therapy was <0...
November 11, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29161666/genetic-variants-and-acute-kidney-injury-a-review-of-the-literature
#12
REVIEW
Daniel B Larach, Milo C Engoren, Ellen M Schmidt, Michael Heung
PURPOSE: Limited data exists on potential genetic contributors to acute kidney injury. This review examines current knowledge of AKI genomics. MATERIALS AND METHODS: 32 studies were selected from PubMed and GWAS Catalog queries for original data studies of human AKI genetics. Hand search of references identified 3 additional manuscripts. RESULTS: 33 of 35 studies were hypothesis-driven investigations of candidate polymorphisms that either did not consistently replicate statistically significant findings, or obtained significant results only in few small-scale studies...
November 13, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29161657/effects-of-local-lipopolysaccharide-administration-on-the-expression-of-toll-like-receptor-4-and-pro-inflammatory-cytokines-in-uterus-and-oviduct-of-rabbit-does
#13
Laura Menchetti, Olimpia Barbato, Iulia Elena Filipescu, Giovanna Traina, Leonardo Leonardi, Angela Polisca, Alessandro Troisi, Gabriella Guelfi, Federica Piro, Gabriele Brecchia
Inflammation of the uterus and oviduct is associated with reduced reproductive performance in humans and domestic animals. Toll-like receptors are expressed in various immune and non-immune cells and play a crucial role in innate immunity. Toll-like receptor - 4 (TLR4) can detect lipopolysaccharide (LPS) from Gram-negative bacteria leading to the secretion of pro-inflammatory cytokines, chemokines, antimicrobial peptides and other inflammatory mediators. To investigate the effects of a local inflammation on the expression levels of TLR4 and pro-inflammatory cytokines, 12 female rabbits received an intracervical infusion with either saline solution endotoxin-free (carrier, 2 mL; n = 6) or LPS (500 μg diluted in 2 mL of saline solution; n = 6)...
November 5, 2017: Theriogenology
https://www.readbyqxmd.com/read/29161655/the-association-between-ambient-temperature-and-mortality-in-south-africa-a-time-series-analysis
#14
Noah Scovronick, Francesco Sera, Fiorella Acquaotta, Diego Garzena, Simona Fratianni, Caradee Y Wright, Antonio Gasparrini
BACKGROUND: There is an extensive literature describing temperature-mortality associations in developed regions, but research from developing countries, and Africa in particular, is limited. METHODS: We conducted a time-series analysis using daily temperature data and a national dataset of all 8.8 million recorded deaths in South Africa between 1997 and 2013. Mortality and temperature data were linked at the district municipality level and relationships were estimated with a distributed lag non-linear model with 21 days of lag, and pooled in a multivariate meta-analysis...
November 18, 2017: Environmental Research
https://www.readbyqxmd.com/read/29161639/specification-plasticity-and-evolutionary-origin-of-peripheral-glial-cells
#15
REVIEW
Maria Eleni Kastriti, Igor Adameyko
Peripheral glia includes predominantly myelinating and non-myelinating Schwann cells in addition to satellite, terminal and enteric glia as well as other unresolved subtypes with localized functions. Of these subtypes, all of them originate from neural crest-derived embryonic Schwann cell precursors (SCPs). Specific gene regulatory networks control neural crest specification and downstream events, including SCP differentiation and myelination. Embryonic SCPs are multipotent and generate neuroendocrine cells, parasympathetic and enteric neurons, melanocytes and other cell types...
November 18, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29161638/to-what-extent-do-structural-changes-in-catalytic-metal-sites-affect-enzyme-function
#16
Yana Valasatava, Antonio Rosato, Nicholas Furnham, Janet M Thornton, Claudia Andreini
About half of known enzymatic reactions involve metals. Enzymes belonging to the same superfamily often evolve to catalyze different reactions on the same structural scaffold. The work presented here investigates how functional differentiation, within superfamilies that contain metalloenzymes, relates to structural changes at the catalytic metal site. In general, when the catalytic metal site is unchanged across the enzymes of a superfamily, the functional differentiation within the superfamily tends to be low and the mechanism conserved...
November 8, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29161637/la-donna-%C3%A3-mobile-lack-of-cyclical-shifts-in-facial-symmetry-and-facial-and-body-masculinity-preferences-a-hormone-based-study
#17
Urszula M Marcinkowska, Andrzej Galbarczyk, Grazyna Jasienska
Although under investigation for more than two decades, a common agreement on the occurrence of cyclical shifts in women's masculinity and symmetry preferences is still missing. Such shifts are considered to be an important feature of sexual selection as they supposedly direct women's attention towards cues for "good genes" (e.g. masculinity and symmetry) during times when probability of conception is the highest. Multiple studies have, however, failed to find these shifts. We attempt to address this lack of agreement analysing a sample of 110 healthy women, using intra-participant design and repeated measurements of oestradiol and LH during the cycle...
November 14, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29161622/on-denny-brown-s-spastic-dystonia-what-is-it-and-what-causes-it
#18
REVIEW
Jakob Lorentzen, Maud Pradines, Jean-Michel Gracies, Jens Bo Nielsen
In this review, we will work around two simple definitions of two different entities, which most often co-exist in patients with lesions to central motor pathways: Spasticity is "Enhanced excitability of velocity-dependent responses to phasic stretch at rest", which will not be the subject of this review, while Spastic dystonia is tonic, chronic, involuntary muscle contraction in the absence of any stretch or any voluntary command (Gracies, 2005). Spastic dystonia is a much less well understood entity that will be the subject this review...
November 4, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29161605/sustainability-of-uk-shale-gas-in-comparison-with-other-electricity-options-current-situation-and-future-scenarios
#19
Jasmin Cooper, Laurence Stamford, Adisa Azapagic
Many countries are considering exploitation of shale gas but its overall sustainability is currently unclear. Previous studies focused mainly on environmental aspects of shale gas, largely in the US, with scant information on socio-economic aspects. To address this knowledge gap, this paper integrates for the first time environmental, economic and social aspects of shale gas to evaluate its overall sustainability. The focus is on the UK which is on the cusp of developing a shale gas industry. Shale gas is compared to other electricity options for the current situation and future scenarios up to the year 2030 to investigate whether it can contribute towards a more sustainable electricity mix in the UK...
November 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29161604/ecological-effects-and-potential-risks-of-the-water-diversion-project-in-the-heihe-river-basin
#20
Mengmeng Zhang, Shuai Wang, Bojie Fu, Guangyao Gao, Qin Shen
To curb the severe ecological deterioration in the lower Heihe River Basin (HRB) in northwest China, a water diversion project was initiated in 2000. A comprehensive analysis of the ecological effects and potential risks associated with the project is needed. We assessed the hydrological and ecological achievements, and also analyzed the potential problems after the project was completed. We found that since the project began the hydrological regime has changed, with more than 57.82% of the upstream water being discharged to the lower reaches on average...
November 18, 2017: Science of the Total Environment
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