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Angiotensinogen cancer

Maíra Casalechi, Cynthia Dela Cruz, Luiza C Lima, Luciana P Maciel, Virgínia M Pereira, Fernando M Reis
The renin-angiotensin system (RAS) involves a complex network of precursors, peptides, enzymes and receptors comprising a systemic (endocrine) and a local (paracrine/autocrine) system. The local RAS plays important roles in tissue modulation and may operate independently of or in close interaction with the circulatory RAS, acting in a complementary fashion. Angiotensin (Ang) II, its receptor AT1 and Ang-(1-7) expression in the endometrium vary with menstrual cycle, and stromal cell decidualization in vitro is accompanied by local synthesis of angiotensinogen and prorenin...
January 20, 2018: Peptides
Benjamin Goldstein, Malav Trivedi, Robert C Speth
OBJECTIVES: The study assessed the existence and significance of associations between the expression of fifteen renin-angiotensin system component genes and lung adenocarcinoma. MATERIALS AND METHODS: NCBI's built-in statistical tool, GEO2R, was used to calculate Student's t-tests for the associations found in a DNA expression study of adenocarcinoma and matched healthy lung tissue samples. The raw data was processed with GeneSpring™ and then used to generate figures with and without Sidak's multiple comparison correction...
2017: Lung Cancer International
J Choi, S Park, T K Kwon, S I Sohn, K M Park, J I Kim
BACKGROUND: Obesity is known as an epidemic worldwide because of consumption of westernized high-fat diets and one of the major risk factors of hypertension. Histone deacetylases (HDACs) control gene expression by regulating histone/non-histone protein deacetylation. HDAC inhibitors exert anti-cancer and anti-inflammatory effects and play a protective role in cardiovascular diseases. In the present study, we tested the effect of an FDA-approved pan-HDAC inhibitor valproic acid (VPA) on high-fat diet (HFD)-induced hypertension in mice...
November 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Xiaohua Chen, Baoxia Li, Rongcheng Luo, Sina Cai, Cao Zhang, Xiaolong Cao
MicroRNA-375 (miR-375) is expressed at low levels in many types of solid tumor, particularly in gastrointestinal tumors. It is considered to be important in the development of cancer and certain diseases. Thus, more detailed knowledge is required on the particular functions of miR-375. miRs function by regulating target genes. Therefore, in the current study, miRWalk (which includes the data from 10 prediction software programs) was used to predict the target genes of miR-375. The genes, which were co-predicted using five different software programs were further analyzed using Database for Annotation, Visualization and Integrated Discovery online software [including gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis]...
May 2017: Biomedical Reports
Mitsumasa Umesawa, Gen Kobashi
Hypertensive disorders in pregnancy (HDP) represent some of the most important problems faced by public health because HDP is a major cause of maternal and prenatal morbidity and mortality. Several epidemiological studies have been performed to determine the prevalence and risk factors of HDP as well as its subtypes. The prevalences of HDP, gestational hypertension and preeclampsia are 5.2-8.2%, 1.8-4.4% and 0.2-9.2%, respectively. Body mass index, anemia and lower education appear to be modifiable risk factors for HDP...
March 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Kirsty G Pringle, Sarah J Delforce, Yu Wang, Katie A Ashton, Anthony Proietto, Geoffrey Otton, C Caroline Blackwell, Rodney J Scott, Eugenie R Lumbers
Endometrial cancer (EC) is the most common gynaecological malignancy and its incidence is increasing. Dysregulation of the endometrial renin-angiotensin system (RAS) could predispose to EC; therefore, we studied the prevalence of RAS single nucleotide polymorphisms (SNPs) in Australian women with EC. SNPs assessed were AGT M235T (rs699); AGTR1 A1166C (rs5186); ACE A240T and T93C (rs4291, rs4292) and ATP6AP2 (rs2968915). They were identified using TaqMan SNP Genotyping Assays. The C allele of the AGTR1 SNP (rs5186) was more prevalent in women with EC (odds ratio (OR) 1...
May 2016: Endocrine Connections
Hong Wang, Kun Zhang, Haifeng Qin, Lin Yang, Liyu Zhang, Yanyan Cao
Earlier published studies investigating the association between polymorphisms in the angiotensinogen gene and lung cancer risk showed no consistent results. In this study, we have summarized all currently available data to examine the correlation by meta-analysis. Case-control studies addressing the association being examined were identified through Embase, the Cochrane Library, ISI Web of Science (Web of Knowledge), Google Scholar, PubMed, and CNKI databases. Risk of lung cancer (odds ratio [OR] and 95% confidence interval [CI]) was estimated with the fixed or the random effects model assuming homozygous, allele, heterozygous, dominant, and recessive models for all angiotensinogen polymorphisms...
September 2015: Medicine (Baltimore)
P Y Hu, Y W Wang, X H Pang, H W Wang
Numerous studies have evaluated the association between the T174M polymorphism in the angiotensinogen (AGT) gene and myocardial infarction (MI) risk. However, the specific association remains controversial because of small sample sizes and varied study designs among different studies. We performed a meta-analysis to assess this correlation. A comprehensive search was conducted to identify all published articles regarding the association between the AGT gene T174M polymorphism and MI risk from different databases...
2015: Genetics and Molecular Research: GMR
Saranya Elavazhagan, Kavin Fatehchand, Vikram Santhanam, Huiqing Fang, Li Ren, Shalini Gautam, Brenda Reader, Xiaokui Mo, Carolyn Cheney, Edward Briercheck, John P Vasilakos, Gregory N Dietsch, Robert M Hershberg, Michael Caligiuri, John C Byrd, Jonathan P Butchar, Susheela Tridandapani
FcγRs are critical mediators of mAb cancer therapies, because they drive cytotoxic processes upon binding of effector cells to opsonized targets. Along with NK cells, monocytes are also known to destroy Ab-coated targets via Ab-dependent cellular cytotoxicity (ADCC). However, the precise mechanisms by which monocytes carry out this function have remained elusive. In this article, we show that human monocytes produce the protease granzyme B upon both FcγR and TLR8 activation. Treatment with TLR8 agonists elicited granzyme B and also enhanced FcγR-mediated granzyme B production in an additive fashion...
March 15, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
Petra Martin, Sinead Noonan, Michael P Mullen, Caitriona Scaife, Miriam Tosetto, Blathnaid Nolan, Kieran Wynne, John Hyland, Kieran Sheahan, Giuliano Elia, Diarmuid O'Donoghue, David Fennelly, Jacintha O'Sullivan
BACKGROUND: Bevacizumab improves progression free survival (PFS) and overall survival (OS) in metastatic colorectal cancer patients however currently there are no biomarkers that predict response to this treatment. The aim of this study was to assess if differential protein expression can differentiate patients who respond to chemotherapy and bevacizumab, and to assess if select proteins correlate with patient survival. METHODS: Pre-treatment serum from patients with metastatic colorectal cancer (mCRC) treated with chemotherapy and bevacizumab were divided into responders and nonresponders based on their progression free survival (PFS)...
2014: BMC Cancer
Yang D Chai, Lifeng Zhang, Yan Yang, Trent Su, Prashant Charugundla, Jiye Ai, Diana Messadi, David T Wong, Shen Hu
BACKGROUND: The purpose of our study was to identify serum protein biomarkers for node-positive oral squamous cell carcinoma (OSCC). Biomarkers indicating lymph node metastasis provides a valuable classification methodology to optimize treatment plans for patients with OSCC. METHODS: Quantitative serum proteomic analysis of OSCCs with either node-positive or node-negative disease was performed with tandem mass spectrometry and isobaric tagging for relative and absolute quantitation (iTRAQ)...
January 2016: Head & Neck
Linyan Zhou, Yi Luo, Seiya Sato, Eriko Tanabe, Misaho Kitayoshi, Rina Fujiwara, Takamitsu Sasaki, Kiyomu Fujii, Hitoshi Ohmori, Hiroki Kuniyasu
Angiotensin II (Ang-II) is a bioactive peptide associated closely with the progression and metastasis of colorectal cancer (CRC). We examined the expression and role of 2 Ang-II receptor types in 20 cases of CRC. Ang-II type 1 receptor (AT1R) protein was localized to the plasma membrane, whereas Ang-II type 2 receptor (AT2R) protein was localized to the nuclei. AT1R expression showed a direct correlation with tumor stage and liver metastasis, whereas AT2R expression showed an inverse correlation. A knockdown study of the AT1R or AT2R with Ang-II treatment was performed to reveal their individual roles in a mouse rectal cell line CMT93, which expresses both Ang-II receptor types...
2014: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
Ivette A Deckers, Piet A van den Brandt, Manon van Engeland, Frederik-Jan van Schooten, Roger W Godschalk, András P Keszei, Leo J Schouten
Hypertension is an established risk factor for renal cell cancer (RCC). The renin-angiotensin-aldosterone system (RAAS) regulates blood pressure and is closely linked to hypertension. RAAS additionally influences homeostasis of electrolytes (e.g. sodium and potassium) and fluid. We investigated single nucleotide polymorphisms (SNPs) in RAAS and their interactions with hypertension and intakes of sodium, potassium and fluid regarding RCC risk in the Netherlands Cohort Study (NLCS), which was initiated in 1986 and included 120,852 participants aged 55 to 69 years...
March 1, 2015: International Journal of Cancer. Journal International du Cancer
G Verhoest, T Dolley-Hitze, F Jouan, K Bensalah, Y Arlot-Bonnemains, F Dugay, M-A Belaud-Rotureau, N Rioux-Leclercq, C Vigneau
INTRODUCTION: A controversy animates the literature on the potential role of the renin-angiotensin system (RAS) in tumorogenesis. The objective of this review was to determine the involvement of this pathway in cancer, and more specifically in urological cancers. MATERIAL AND METHOD: We made a systematic review of articles referenced in Pubmed, using the following keywords alone or combined: cancer, renin, angiotensin, VEGF, AT1R, antagonists of angiotensin-2 receptors, inhibitors of angiotensinogen converting...
February 2014: Progrès en Urologie
Antonis Vylliotis, Christos Yapijakis, Emeka Nkenke, Themistoklis Nisyrios, Dimitrios Avgoustidis, Maria Adamopoulou, Vasilios Ragos, Stavros Vassiliou, Nikolas Koronellos, Eleftherios Vairaktaris
It is well-known that there is an interplay between hemostasis, thrombosis and cancer. Functional DNA polymorphisms in genes encoding factors related to thrombosis have been associated with increased risk for oral squamous cell carcinoma (OSCC). The present study investigated the possible combinatory effect of 10 such polymorphisms as primary risk predictors for OSCC in a European population. Two groups including 160 patients with OSCC and 168 healthy controls of Greek and German origin were studied. The patient and control groups were comparable regarding ethnicity, age and gender...
September 2013: Anticancer Research
Daniela Vivenza, Mauro Feola, Ornella Garrone, Martino Monteverde, Marco Merlano, Cristiana Lo Nigro
BACKGROUND: Anthracyclines are among the most active drugs against breast cancer, but can exert cardiotoxic effects eventually resulting in congestive heart failure (CHF). Identifying breast cancer patients at high risk of developing cardiotoxicity after anthracycline therapy would be of value in guiding the use of these agents. AIMS: We determined whether polymorphisms in the renin-angiotensin-aldosterone system (RAAS) and in the glutathione S-transferase (GST) family of phase II detoxification enzymes might be useful predictors of left ventricular ejection fraction (LVEF) kinetics and risk of developing CHF...
December 17, 2013: International Journal of Biological Markers
Jianjun Lin, Jiayu Chen, Chibo Liu
OBJECTIVE: The angiotensinogen (AGT) gene has been considered to be implicated in the development of cancer. However, the results have been inconsistent. In this study, we performed a meta-analysis to clarify the association of AGT M235T variant with cancer risk. METHODS: Published literature from PubMed and Embase were retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using a fixed- or random-effects model. RESULTS: A total of seven articles including eight studies (3639 cancer cases and 6684 controls) for AGT M235T variant were included...
June 2015: Journal of the Renin-angiotensin-aldosterone System: JRAAS
Dexiang Zhu, Yunshi Zhong, Haifu Wu, Lechi Ye, Jie Wang, Yan Li, Ye Wei, Li Ren, Bin Xu, Jianmin Xu, Xinyu Qin
BACKGROUND: There are currently no accurate predictive markers of metachronous liver metastasis (MLM) from colorectal cancer. METHODS: Magnetic bead-based fractionation coupled with mass spectrometry analysis was used to compare serum samples from 64 patients with MLM and 64 without recurrence or metastasis for at least 3 y after radical colorectal surgery (NM). A total of 40 MLM and 40 NM serum samples were randomly selected to build a decision tree, and the remainder were tested as blinded samples...
October 2013: Journal of Surgical Research
James Leung, Wei Wei, Limin Liu
In human hepatocellular carcinoma (HCC) and many other cancers, somatic point mutations are highly prevalent, yet the mechanisms critical in their generation remain poorly understood. S-nitrosoglutathione reductase (GSNOR), a key regulator of protein S-nitrosylation, is frequently deficient in human HCC. Targeted deletion of the GSNOR gene in mice can reduce the activity of the DNA repair protein O (6)-alkylguanine-DNA alkyltransferase (AGT) and promote both carcinogen-induced and spontaneous HCC. In this study, we report that following exposure to the environmental carcinogen diethylnitrosamine, the mutation frequency of a transgenic reporter in the liver of GSNOR-deficient mice (GSNOR(-/-)) is significantly higher than that in wild-type control...
May 2013: Carcinogenesis
Thibault Dolley-Hitze, Grégory Verhoest, Florence Jouan, Patrick Le Pogamp, Yannick Arlot-Bonnemains, Emmanuel Oger, Marc-Antoine Belaud-Rotureau, Nathalie Rioux-Leclercq, Cécile Vigneau
Recently, several meta-analysis suggested an increased risk of cancers linked to the use of antagonists of angiotensin-2 receptors or inhibitors of angiotensinogen converting enzyme. The results of epidemiological studies are conflicting. Meta-analysis as well as retrospective studies are not reliable and biased, since they have never been designed to explore any pro- or antitumoral effect. We lack of prospective studies that could take off the doubt on these drugs. Nevertheless, all experimental researches pointed out potent antitumoral properties...
April 2013: Néphrologie & Thérapeutique
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