keyword
MENU ▼
Read by QxMD icon Read
search

Predictive biomarker

keyword
https://www.readbyqxmd.com/read/29356308/high-number-of-pd-1-positive-intratumoral-lymphocytes-predict-survival-benefit-of-cik-cells-for-hepatocellular-carcinoma-patients
#1
Boyang Chang, Lujun Shen, Kefeng Wang, Jietian Jin, Tao Huang, Qifeng Chen, Wang Li, Peihong Wu
BACKGROUND & AIMS: Adjuvant cytokine-induced killer (CIK) cells treatment has shown potential in reducing the recurrence rate and prolonging the survival of patients with hepatocellular carcinoma (HCC). We aimed to identify the best predictive biomarker for adjuvant CIK cells treatment in patients with HCC after curative resection. METHODS: This study retrospectively included 145 pairs of HCC patients by one-to-one propensity score matching. One group received CIK cells transfusion after surgery (Surgery-CIK group); the other one group underwent surgery only (Surgery-only group)...
January 22, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29356297/understanding-the-roles-of-glutamine-synthetase-glutaminase-and-glutamate-decarboxylase-autoantibodies-in-imbalanced-excitatory-inhibitory-neurotransmission-as-etiological-mechanisms-of-autism
#2
Najat O Hamed, Laila-Al-Ayadhi, Mohamed A Osman, Elkhawad Abdalla O, Hanan Qasem, Majida Al-Marshoud, Nada M Merghani, Afaf El-Ansary
BACKGROUND: AIM: Autism is a heterogeneous neurological disorder that is characterized by impairments in communication and social interactions, repetitive behaviors and sensory abnormalities. The etiology of autism remains unclear. Animal, genetic and postmortem studies suggest that an imbalance exists in the neuronal excitation and inhibition (E/I) system in autism. The aim of this study was to determine whether alterations of the measured parameters in children with autism are significantly associated with the risk of a sensory dysfunction...
January 22, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29355796/clinical-utility-of-serum-procalcitonin-level-and-infection-in-the-neurosurgical-intensive-care-unit
#3
Lauren E Rotman, Bonita S Agee, Gustavo Chagoya, Matthew C Davis, James M Markert
OBJECTIVE: Procalcitonin, a blood stream inflammatory biomarker, has shown to be useful in the diagnosis of sepsis in critically ill patients treated in medical and surgical intensive care units. This study aims to further our understanding of procalcitonin levels in Neuroscience Intensive Care Unit (NICU) patients. METHODS: Neurosurgical patients who underwent procalcitonin assay in the NICU over a two-year period were included. Procalcitonin equal to or above 0...
January 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29355653/discovery-and-validation-of-serum-creatinine-variability-as-novel-biomarker-for-predicting-onset-of-albuminuria-in-type-2-diabetes-mellitus
#4
Serena Low, Xiao Zhang, Keven Ang, Su Jian Darren Yeo, Guanyi Joel Lim, Lee Ying Yeoh, Yan Lun Liu, Tavintharan Subramaniam, Chee Fang Sum, Su Chi Lim
AIM: We aim to study association serum creatinine(cr) variability and albuminuria progression. METHODS: We conducted a retrospective cohort study on patients with Type 2 Diabetes Mellitus at a Diabetes Centre in Singapore ("discovery cohort"). Outcome is worsening of urinary albumin-to-creatinine(ACR) across stages. Cr variability was expressed as adjusted cr-intrapersonal standard deviation(SD) and coefficient-of-variation(cr-CV). A separate cohort was used for validating association between cr variability and albuminuria progression ("validation cohort")...
January 17, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29355614/head-and-neck-squamous-cell-carcinoma-genomics-and-emerging-biomarkers-for-immunomodulatory-cancer-treatments
#5
REVIEW
Benjamin Solomon, Richard J Young, Danny Rischin
Head and neck squamous cell carcinoma (HNSCC) comprises a heterogeneous group of tumors that arise from the squamous epithelium of the oral cavity, oropharynx, larynx and hypopharynx. While many HNSCCs are related to classical etiologic factors of smoking and alcohol, a clinically, genomically, and immunologically distinct subgroup of tumors arise from the epithelium of the tonsil and the base of tongue as a result of infection with Human Papilloma Virus (HPV). In this review we describe the genomic and immunologic landscape of HNSCC, highlighting differences between HPV-positive and HPV-negative HNSCC...
January 17, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29355613/histopathological-growth-patterns-as-a-candidate-biomarker-for-immunomodulatory-therapy
#6
REVIEW
Pieter-Jan van Dam, Sofie Daelemans, Elizabeth Ross, Yannick Waumans, Steven Van Laere, Emily Latacz, Roanne Van Steen, Christel De Pooter, Mark Kockx, Luc Dirix, Peter B Vermeulen
The encroachment of a growing tumor upon the cells and structures of surrounding normal tissue results in a series of histopathological growth patterns (HGPs). These morphological changes can be assessed in hematoxylin-and-eosin (H&E) stained tissue sections from primary and metastatic tumors and have been characterized in a range of tissue types including liver, lung, lymph node and skin. HGPs in different tissues share certain general characteristics like the extent of angiogenesis, but also appropriate tissue-specific mechanisms which ultimately determine differences in the biology of HGP subtypes...
January 17, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29355551/baseline-and-serial-brain-natriuretic-peptide-level-predicts-5-year-overall-survival-in-patients-with-pulmonary-arterial-hypertension-data-from-the-reveal-registry
#7
Robert P Frantz, Harrison W Farber, David B Badesch, C Greg Elliott, Adaani E Frost, Michael D McGoon, Carol Zhao, David R Mink, Mona Selej, Raymond L Benza
BACKGROUND: Plasma brain natriuretic peptide (BNP) level is a prognostic biomarker in pulmonary arterial hypertension (PAH). Its impact on long-term overall survival (OS) was investigated in REVEAL, a 5-year observational, multicenter, United States registry of patients with PAH. METHODS: Patients were aged ≥18 years, met right heart catheterization criteria at rest, had WHO Group I PAH, and BNP measurement at enrollment. Optimal BNP threshold was obtained via receiver operating characteristic curve analysis...
January 16, 2018: Chest
https://www.readbyqxmd.com/read/29355524/long-non-coding-rna-uca1-promotes-lung-cancer-cell-proliferation-and-migration-via-microrna-193a-hmgb1-axis
#8
Hongyu Wu, Caicun Zhou
Lung cancer is a leading cause of death worldwide. Long non-coding RNAs have been documented aberrantly expressed and exerted crucial role in variety of cancers. Urothelial carcinoma associated 1 (UCA1) is a potential new type of biomarkers for tumor diagnosis and exerts oncogenic effect on various human cancers. However, the mechanism of oncogenic role of UCA1 in lung cancer remains unclear. In this study, we firstly confirmed the role of UCA1 in lung cancer and found that UCA1 down-regulation inhibited cell proliferation and migration in both SKMES-1 and H520 lung cancer cells...
January 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29355441/ntprobnp-and-st2-as-predictors-for-all-cause-and-cardiovascular-mortality-in-elderly-patients-with-symptoms-suggestive-for-heart-failure
#9
Kurt Boman, Finn Thormark Fröst, Ann-Charlotte R Bergman, Mona Olofsson
BACKGROUND: A new biomarker, suppression of tumorigenicity 2 (ST2) has been introduced as a marker for fibrosis and hypertrophy. Its clinical value in comparison with NTproBNP in predicting mortality in elderly patients with symptoms of heart failure (HF) is still unclear. AIM: To evaluate the prognostic value for all-cause- and cardiovascular mortality of ST2 or NTproBNP and secondly; the combination of these biomarkers. PATIENTS AND METHODS: 170 patients with clinical symptoms of HF of whom 77 (45%) with verified HF were recruited from one selected primary health care centre (PHC) in Sweden and echocardiography was performed in all patients...
January 22, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29355436/can-biomarkers-help-target-maturity-onset-diabetes-of-the-young-genetic-testing-in-antibody-negative-diabetes
#10
Shideh Majidi, Alexandra Fouts, Laura Pyle, Christina Chambers, Taylor Armstrong, Zhenyuan Wang, Sat Dev Batish, Georgeanna Klingensmith, Andrea K Steck
BACKGROUND: Maturity-onset diabetes of the young (MODY) is an antibody-negative, autosomal dominant form of diabetes. With the increasing prevalence of diabetes and the expense of MODY testing, markers to identify those who need further genetic testing would be beneficial. We investigated whether HLA genotypes, random C-peptide, and/or high-sensitivity C-reactive protein (hsCRP) levels could be helpful biomarkers for identifying MODY in antibody-negative diabetes. METHODS: Subjects (N = 97) with diabetes onset ≤age 25, measurable C-peptide (≥0...
February 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29355422/oral-microbiome-studies-potential-diagnostic-and-therapeutic-implications
#11
A Mira
Understanding the microbiology of dental caries is not a mere academic exercise; it provides the basis for preventive, diagnostic, and treatment strategies and gives the dentist a theoretical framework to become a better professional. The last years have seen the development of new research methodologies, ranging from high-throughput sequencing or "omics" techniques to new fluorescence microscopy applications and microfluidics, which have allowed the study of the oral microbiome to an unprecedented level of detail...
February 2018: Advances in Dental Research
https://www.readbyqxmd.com/read/29355349/faster-alcohol-metabolism-is-associated-with-increased-stimulation-and-within-session-consumption
#12
Stephen J Boyd, William R Corbin
Variability in subjective response (SR) to alcohol predicts drinking and the development of Alcohol Use Disorders (AUDs). Although both alcohol pharmacokinetics (i.e., absorption and metabolism) and SR are impacted by aspects of the drinking situation (e.g., rate of consumption), relations between individual differences in pharmacokinetics and SR have received little attention. The current study examined the extent to which alcohol pharmacokinetics impact SR and drinking during a single alcohol administration session...
January 22, 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29355114/synergistic-role-of-caspase-8-and-caspase-3-expressions-prognostic-and-predictive-biomarkers-in-colorectal-cancer
#13
Qiang Yao, Weimin Wang, Jun Jin, Ke Min, Jian Yang, Yubing Zhong, Chunni Xu, Jianliang Deng, Yan Zhou
BACKGROUND: Expressions of Caspase-8 and Caspase-3 have been identified as important markers in many malignant tumors, but their roles in colorectal cancer (CRC) have not been confirmed. The purpose of this study was to investigate the role of Caspase-8 and Caspase-3 in CRC. METHODS: We enrolled 470 CRC patients in this study. Archival paraffin-embedded CRC tissue samples were used to construct tissue microarray (TMA), expressions of Caspase-8 and Caspase-3 that were stained by immunohistochemistry...
January 12, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29354499/online-tools-for-patient-counseling-in-bladder-and-kidney-cancer-ready-for-prime-time
#14
REVIEW
Philipp Gild, Michael Rink, Christian P Meyer
Gauging prognosis is a key element when facing treatment decisions in cancer care. Several prognostic tools, such as risk tables and nomograms are at hand to aid this process. In the context of patient-centered care, prognostic tools are of great interest to caregivers and -providers alike, as they can convey sizeable amounts of information and provide tailored, accurate estimates of prognosis. Given the rising number of prognostic tools in cancer care over the last two decades, and similarly, ever increasing presence of the Internet, we aimed to assess how this would translate into the availability of online tools for patient counseling...
December 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29354496/the-current-status-and-clinical-value-of-circulating-tumor-cells-and-circulating-cell-free-tumor-dna-in-bladder-cancer
#15
REVIEW
Sabine Riethdorf, Armin Soave, Michael Rink
Urothelial carcinoma of the bladder (UCB) is a complex disease, which is associated with highly aggressive tumor biologic behavior, especially in patients with muscle-invasive and advanced tumors. Despite multimodal therapy options including surgery, radiotherapy and chemotherapy, UCB patients frequently suffer from poor clinical outcome. Indeed, the potential of diverse opportunities for modern targeted therapies is not sufficiently elucidated in UCB yet. To improve the suboptimal treatment situation in UCB, biomarkers are urgently needed that help detecting minimal residual disease (MRD), predicting therapy response and subsequently prognosis as well as enabling patient stratification for further therapies and therapy monitoring, respectively...
December 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29354494/do-we-have-biomarkers-to-predict-response-to-neoadjuvant-and-adjuvant-chemotherapy-and-immunotherapy-in-bladder-cancer
#16
REVIEW
Felix Wezel, Stefan Vallo, Florian Roghmann
Radical cystectomy (RC) is the standard of care treatment of localized muscle-invasive bladder cancer (BC). However, about 50% of patients develop metastases within 2 years after cystectomy. Neoadjuvant cisplatin-based chemotherapy before cystectomy improves the overall survival (OS) in patients with muscle-invasive BC. Pathological response to neoadjuvant treatment is a strong predictor of better disease-specific survival. Nevertheless, some patients do not benefit from chemotherapy. The identification of reliable biomarkers enabling clinicians to identify patients who might benefit from chemotherapy is a very important clinical task...
December 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29354491/opportunities-of-next-generation-sequencing-in-non-muscle-invasive-bladder-cancer-outcome-prediction
#17
REVIEW
Karl H Pang, Francesco Esperto, Aidan P Noon
Bladder cancer (BC) is a common disease in both sexes and majority of cases present as non-muscle invasive BC (NMIBC). The percentage of NMIBC progressing to muscle invasive BC (MIBC) varies between 25% and 75% and currently there are no reliable biomarkers that may predict the outcome of high-risk (HR) NMIBC. Whilst The Cancer Genome Atlas (TCGA) project has identified genetic alteration in MIBC using next-generation sequencing (NGS), genetic data in HR-NMIBC outcome prediction using this new technology are limited...
December 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29353887/p11-promoter-methylation-predicts-the-antidepressant-effect-of-electroconvulsive-therapy
#18
Alexandra Neyazi, Wiebke Theilmann, Claudia Brandt, Tomi Rantamäki, Nobuaki Matsui, Mathias Rhein, Johannes Kornhuber, Malek Bajbouj, Wolfgang Sperling, Stefan Bleich, Helge Frieling, Wolfgang Löscher
Although electroconvulsive therapy (ECT) is among the most effective treatment options for pharmacoresistant major depressive disorder (MDD), some patients still remain refractory to standard ECT practise. Thus, there is a need for markers reliably predicting ECT non/response. In our study, we have taken a novel translational approach for discovering potential biomarkers for the prediction of ECT response. Our hypothesis was that the promoter methylation of p11, a multifunctional protein involved in both depressive-like states and antidepressant treatment responses, is differently regulated in ECT responders vs...
January 22, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29353682/predicting-the-risk-of-recurrent-venous-thromboembolism-in-patients-with-cancer-a-prospective-cohort-study
#19
Nick van Es, Martha Louzada, Marc Carrier, Vicky Tagalakis, Peter L Gross, Sudeep Shivakumar, Marc A Rodger, Philip S Wells
BACKGROUND: The risk of recurrent venous thromboembolism (VTE) in cancer patients despite anticoagulant therapy is high. Clinical factors and pro-coagulant markers may identify high-risk patients and guide decisions about intensifying anticoagulation therapy. AIMS: To evaluate whether serial measurements of pro-coagulant markers can identify patients at high risk of recurrent VTE. METHODS: In this multicenter, prospective cohort study, patients with active cancer and acute deep vein thrombosis or pulmonary embolism were enrolled...
January 9, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29353445/hypermethylation-of-nf-%C3%AE%C2%BAb-activating-protein-like-nkapl-promoter-in-hepatocellular-carcinoma-suppresses-its-expression-and-predicts-a-poor-prognosis
#20
Patrick Kwok Shing Ng, Carol Po Ying Lau, Emily Kai Yee Lam, Sheila Sai Kam Li, Vivian Wai Yan Lui, Winnie Yeo, Yuen Keng Ng, Paul Bo San Lai, Stephen Kwok Wing Tsui
BACKGROUND AND AIM: Hepatocellular carcinoma (HCC) is a complicated disease with low survival rate partially due to frequent recurrence and no efficient therapy. Promoter hypermethylation of tumor suppressor genes has been demonstrated as one of the molecular mechanisms contributing to tumorigenesis and progression in HCC. This study aims to investigate regulation of NKAPL expression by promoter methylation and its clinical relevance as a biomarker for HCC. METHODS: We measured mRNA expression of NKAPL in 5 HCC cell lines and a cohort of 62 pairs of primary HCC tumor and their adjacent non-cancer liver tissues...
January 20, 2018: Digestive Diseases and Sciences
keyword
keyword
80320
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"