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https://www.readbyqxmd.com/read/27933485/fluid-based-biomarkers-for-amyotrophic-lateral-sclerosis
#1
REVIEW
Lucas T Vu, Robert Bowser
Amyotrophic lateral sclerosis (ALS) is a highly heterogeneous disease with no effective treatment. Drug development has been hampered by the lack of biomarkers that aid in early diagnosis, demonstrate target engagement, monitor disease progression, and can serve as surrogate endpoints to assess the efficacy of treatments. Fluid-based biomarkers may potentially address these issues. An ideal biomarker should exhibit high specificity and sensitivity for distinguishing ALS from control (appropriate disease mimics and other neurologic diseases) populations and monitor disease progression within individual patients...
December 8, 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27933468/conditional-screening-for-ultra-high-dimensional-covariates-with-survival-outcomes
#2
Hyokyoung G Hong, Jian Kang, Yi Li
Identifying important biomarkers that are predictive for cancer patients' prognosis is key in gaining better insights into the biological influences on the disease and has become a critical component of precision medicine. The emergence of large-scale biomedical survival studies, which typically involve excessive number of biomarkers, has brought high demand in designing efficient screening tools for selecting predictive biomarkers. The vast amount of biomarkers defies any existing variable selection methods via regularization...
December 8, 2016: Lifetime Data Analysis
https://www.readbyqxmd.com/read/27933384/thyroid-autoimmunity-is-really-associated-with-papillary-thyroid-carcinoma
#3
Alev Selek, Berrin Cetinarslan, Ilhan Tarkun, Zeynep Canturk, Berna Ustuner, Zeynep Akyay
The incidence of thyroid cancer has been greatly increasing. Several studies aimed to investigate biomarkers for prediction of thyroid cancer. Some of these studies have suggested that thyroid autoantibodies (TAb) could be used as predictors of thyroid cancer risk, but the correlation between TAb and PTC is still a matter of debate. The aim of this study is to evaluate thyroid autoimmunity and TAbs in patients with PTC and benign multinodular goiter (MNG) to investigate if TAbs and autoimmune thyroid disease (ATD) could predict thyroid malignancy...
December 8, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27933273/prognostic-value-of-plasma-and-urine-glycosaminoglycan-scores-in-clear-cell-renal-cell-carcinoma
#4
Francesco Gatto, Marco Maruzzo, Cristina Magro, Umberto Basso, Jens Nielsen
BACKGROUND: The prognosis of metastatic clear cell renal cell carcinoma (ccRCC) vastly improved since the introduction of antiangiogenic-targeted therapy. However, it is still unclear which biological processes underlie ccRCC aggressiveness and affect prognosis. Here, we checked whether a recently discovered systems biomarker based on plasmatic or urinary measurements of glycosaminoglycans (GAGs) aggregated into diagnostic scores correlated with ccRCC prognosis. METHODS: Thirty-one patients with a diagnosis of ccRCC (23 metastatic) were prospectively enrolled, and their urine and plasma biomarker scores were correlated to progression-free survival (PFS) and overall survival (OS) as either a dichotomous ("Low" vs...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27932890/high-expression-of-hmga2-predicts-poor-survival-in-patients-with-clear-cell-renal-cell-carcinoma
#5
Ning Na, Tujie Si, Zhengyu Huang, Bin Miao, Liangqing Hong, Heng Li, Jiang Qiu, Jianguang Qiu
High-mobility group AT-hook 2 (HMGA2) is involved in a wide spectrum of biological processes and is upregulated in several tumors, but its role in renal carcinoma remains unclear. The aim of this study was to examine the expression of HMGA2 and its relationship to the overall survival (OS) of patients with non-metastatic clear cell renal cell carcinoma (ccRCC) following surgery. The expression of HMGA2 was evaluated retrospectively by immunohistochemistry (IHC) in 162 patients with ccRCC who underwent nephrectomy in 2003 and 2004...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27932665/statistical-analysis-of-a-low-cost-method-for-multiple-disease-prediction
#6
Mohsen Bayati, Sonia Bhaskar, Andrea Montanari
Early identification of individuals at risk for chronic diseases is of significant clinical value. Early detection provides the opportunity to slow the pace of a condition, and thus help individuals to improve or maintain their quality of life. Additionally, it can lessen the financial burden on health insurers and self-insured employers. As a solution to mitigate the rise in chronic conditions and related costs, an increasing number of employers have recently begun using wellness programs, which typically involve an annual health risk assessment...
December 8, 2016: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/27932568/targeting-hif2-in-clear-cell-renal-cell-carcinoma
#7
Hyejin Cho, William G Kaelin
Inactivation of the von Hippel-Lindau tumor-suppressor protein (pVHL) is the signature "truncal" event in clear cell renal cell carcinoma, which is the most common form of kidney cancer. pVHL is part of a ubiquitin ligase the targets the α subunit of the hypoxia-inducible factor (HIF) transcription factor for destruction when oxygen is available. Preclinical studies strongly suggest that deregulation of HIF, and particularly HIF2, drives pVHL-defective renal carcinogenesis. Although HIF2α was classically considered undruggable, structural and chemical work by Rick Bruick and Kevin Gardner at University of Texas Southwestern laid the foundation for the development of small molecule direct HIF2α antagonists (PT2385 and the related tool compound PT2399) by Peloton Therapeutics that block the dimerization of HIF2α with its partner protein ARNT1...
December 8, 2016: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/27932553/normalization-matters-tracking-the-best-strategy-for-sperm-mirna-quantification
#8
Celia Corral-Vazquez, Joan Blanco, Albert Salas-Huetos, Francesca Vidal, Ester Anton
STUDY QUESTION: What is the most reliable normalization strategy for sperm microRNA (miRNA) quantitative Reverse Transcription Polymerase Chain Reactions (qRT-PCR) using singleplex assays? SUMMARY ANSWER: The use of the average expression of hsa-miR-100-5p and hsa-miR-30a-5p as sperm miRNA qRT-PCR data normalizer is suggested as an optimal strategy. WHAT IS KNOWN ALREADY: Mean-centering methods are the most reliable normalization strategies for miRNA high-throughput expression analyses...
December 8, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27932413/biomarkers-and-coronary-lesions-predict-outcomes-after-revascularization-in-non-st-elevation-acute-coronary-syndrome
#9
Daniel Lindholm, Stefan K James, Maria Bertilsson, Richard C Becker, Christopher P Cannon, Evangelos Giannitsis, Robert A Harrington, Anders Himmelmann, Frederic Kontny, Agneta Siegbahn, Philippe Gabriel Steg, Robert F Storey, Matthijs A Velders, W Douglas Weaver, Lars Wallentin
BACKGROUND: Risk stratification in non-ST-elevation acute coronary syndrome (NSTE-ACS) is currently mainly based on clinical characteristics. With routine invasive management, angiography findings and biomarkers are available and may improve prognostication. We aimed to assess if adding biomarkers [high-sensitivity cardiac troponin T (cTnT-hs), N-terminal probrain-type natriuretic peptide (NT-proBNP), growth differentiation factor 15 (GDF-15)] and extent of coronary artery disease (CAD) might improve prognostication in revascularized patients with NSTE-ACS...
December 8, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27932126/pretransplant-cd28-biomarker-levels-of-expression-and-quantification-of-molecules-per-cell-in-peripheral-cd4-t-cells-predicts-acute-rejection-episodes-in-liver-and-kidney-recipients
#10
F Boix, J M Bolarín, J Eguía, G Gonzalez-Martinez, J De La Peña, J A Galian, A M Hernández-Martínez, M R Moya-Quiles, I Legaz, J A Campillo, P Ramirez, F Sanchez-Bueno, A M García-Alonso, J A Pons, A Minguela, S Llorente, M Muro
BACKGROUND: Acute rejection (AR) remains a significant cause of graft loss. Better approaches to predict AR are being investigated. Surface CD28 protein is essential for T-cell proliferation and survival as well as cytokine production. PATIENTS AND METHODS: Pretransplant CD4(+)CD28(+) peripheral T cells were examined in 30 liver recipients (LRs) and 31 kidney recipients (KRs) by flow cytometry. RESULTS: Pretransplant CD4(+)CD28(+) T cells in LRs were significantly lower in rejectors than nonrejectors (P = ...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931880/predictive-diagnosis-of-major-depression-using-nmr-based-metabolomics-and-least-squares-support-vector-machine
#11
Hong Zheng, Peng Zheng, Liangcai Zhao, Jianmin Jia, Shengli Tang, Pengtao Xu, Peng Xie, Hongchang Gao
BACKGROUND: Major depressive (MD) disorder is a serious psychiatric disorder that can result in suicidal behavior if not treated. The MD diagnosis using a standardized instrument instead of a structured interview will be advantageous for treatment and management of the MD, but so far no such technique exists. We developed an integrated analytical method of NMR-based metabolomics and least squares-support vector machine (LS-SVM) for predictive diagnosis of the MD. METHODS: The metabolite profiles in clinical plasma samples obtained from 72 depressive patients and 54 healthy subjects were analyzed by NMR spectroscopy...
December 5, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27931558/time-to-shift-from-contemporary-to-high-sensitivity-cardiac-troponin-in-diagnosis-of-acute-coronary-syndromes
#12
REVIEW
Jamshed J Dalal, C K Ponde, Brian Pinto, C N Srinivas, Joy Thomas, Sunil Kumar Modi, Sanjay Mehta, Suvin Shetty, Manimarane, Bhupen Desai
Early rule-in and rule-out of non-ST-segment elevation myocardial infarction (NSTEMI) is a challenge. In patients with inconclusive findings on ECG, cardiac biomarkers play a crucial role in the diagnosis. The introduction of the new high-sensitive cardiac troponin test (hs-TnI assay) has changed the landscape of NSTEMI diagnosis. The new hs-TnI assay can detect troponin values at a lower level compared with a contemporary cardiac troponin (cTn) assay. The hs-cTnI assay has a coefficient of variation of ≤10%, well below the 99th percentile value...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27931342/evaluation-of-serum-inflammatory-biomarkers-as-predictors-of-treatment-outcome-in-pulmonary-tuberculosis
#13
A Singanayagam, K Manalan, D W Connell, J D Chalmers, S Sridhar, A I Ritchie, A Lalvani, M Wickremasinghe, O M Kon
OBJECTIVE: To evaluate C-reactive protein (CRP), globulin and white blood cell (WBC) count as predictors of treatment outcome in pulmonary tuberculosis (PTB). METHODS: An observational study of patients with active PTB was conducted at a tertiary centre. All patients had serum CRP, globulin and WBC measured at baseline and at 2 months following commencement of treatment. The outcome of interest was requirement for extension of treatment beyond 6 months. RESULTS: There were 226 patients included in the study...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27930697/early-antenatal-prediction-of-gestational-diabetes-in-obese-women-development-of-prediction-tools-for-targeted-intervention
#14
Sara L White, Debbie A Lawlor, Annette L Briley, Keith M Godfrey, Scott M Nelson, Eugene Oteng-Ntim, Stephen C Robson, Naveed Sattar, Paul T Seed, Matias C Vieira, Paul Welsh, Melissa Whitworth, Lucilla Poston, Dharmintra Pasupathy
All obese women are categorised as being of equally high risk of gestational diabetes (GDM) whereas the majority do not develop the disorder. Lifestyle and pharmacological interventions in unselected obese pregnant women have been unsuccessful in preventing GDM. Our aim was to develop a prediction tool for early identification of obese women at high risk of GDM to facilitate targeted interventions in those most likely to benefit. Clinical and anthropometric data and non-fasting blood samples were obtained at 15+0-18+6 weeks' gestation in 1303 obese pregnant women from UPBEAT, a randomised controlled trial of a behavioural intervention...
2016: PloS One
https://www.readbyqxmd.com/read/27930558/urinary-%C3%AE-trace-protein-a-unique-biomarker-to-screen-early-glomerular-filtration-rate-impairment
#15
Carlo Donadio, Laura Bozzoli
The screening for chronic kidney disease (CKD) patients needs the measurement of serum markers like creatinine. Our previous results indicated that urinary excretion of β-trace protein (BTP), a low-molecular-weight protein (23-29 kDa), is increased in CKD patients from stage 2. The aim of this study was to assess the major determinants of urinary excretion of BTP and to evaluate its feasibility as noninvasive marker of glomerular filtration rate (GFR) impairment.We studied 355 CKD patients (198 males), aged 15 to 83 years, in stable clinical conditions, classified in the different stages of CKD on the basis of GFR (renal clearance of Tc-diethylenetriamine penta-acetic acid)...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930409/serum-amyloid-a-as-a-surrogate-marker-for-mucosal-and-histologic-inflammation-in-patients-with-crohn-s-disease
#16
Andres J Yarur, Maria A Quintero, Anjali Jain, Frank Czul, Jamie S Barkin, Maria T Abreu
BACKGROUND: Serum amyloid A (SAA) is an acute-phase protein, but its role as a biomarker of disease activity in Crohn's disease is unclear. The aim of the study was to assess the correlation between SAA, inflammatory cytokines, and mucosal inflammation in patients with Crohn's disease and to investigate whether this marker might be useful in patients who do not have elevated C-reactive protein (CRP) levels despite having active disease. METHODS: Cross-sectional study including patients with Crohn's disease who underwent colonoscopies for assessment of disease activity...
December 7, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27930406/stress-response-protein-rbm3-promotes-the-development-of-colitis-associated-cancer
#17
Toshiharu Sakurai, Hiroshi Kashida, Yoriaki Komeda, Tomoyuki Nagai, Satoru Hagiwara, Tomohiro Watanabe, Masayuki Kitano, Naoshi Nishida, Jun Fujita, Masatoshi Kudo
BACKGROUND: Colitis-associated cancer (CAC) is caused by chronic intestinal inflammation and often results from refractory inflammatory bowel disease (IBD). Stress response proteins Cirp and HSPA4 are involved in the refractory clinical course and development of CAC. RNA-binding motif protein 3 (RBM3) is induced in response to various stresses and is upregulated in several cancers. However, the role of RBM3 in CAC is unclear. METHODS: We assessed RBM3 expression and function in 263 human intestinal mucosa samples from patients with IBD and in Rbm3-deficient (Rbm3) mice...
December 7, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27930387/noninvasive-estimation-of-liver-fibrosis-in-biopsy-proven-hepatitis-c-virus-infected-patients-angiogenic-fibrogenic-link
#18
El-Shahat A Toson, Gamal E Shiha, Hatem A El-Mezayen, Waleed Samir, Mohamed M El-Khininy
BACKGROUND/AIM: The assessment of liver fibrosis provides useful information not only for diagnosis but also for therapeutic decisions. This study aimed to develop and evaluate a predictive score named the angiogenic index (Angio-Index) for liver fibrosis staging and to compare Angio-Index by King, Gotebörg University Cirrhosis Index, Lok, FIB-4, and aspartate aminotranferase/alanine aminotranferase scores in hepatitis C virus-infected patients. PATIENTS AND METHODS: Serum levels of angiopoietin-2, basic fibroblast growth factor, hepatocyte growth factor, and endostatin were assayed using an enzyme-linked immunosorbent assay in 122 HCV patients represented in two sets (estimation group and validation group)...
December 7, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27929242/community-acquired-pneumonia-in-adults-diagnosis-and-management
#19
Alexander Kaysin, Anthony J Viera
Community-acquired pneumonia is a leading cause of death. Risk factors include older age and medical comorbidities. Diagnosis is suggested by a history of cough, dyspnea, pleuritic pain, or acute functional or cognitive decline, with abnormal vital signs (e.g., fever, tachycardia) and lung examination findings. Diagnosis should be confirmed by chest radiography or ultrasonography. Validated prediction scores for pneumonia severity can guide the decision between outpatient and inpatient therapy. Using procalcitonin as a biomarker for severe infection may further assist with risk stratification...
November 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27929120/neurofilaments-in-blood-and-csf-for-diagnosis-and-prediction-of-onset-in-creutzfeldt-jakob-disease
#20
Petra Steinacker, Kaj Blennow, Steffen Halbgebauer, Song Shi, Viktoria Ruf, Patrick Oeckl, Armin Giese, Jens Kuhle, Dana Slivarichova, Henrik Zetterberg, Markus Otto
While cerebrospinal fluid (CSF) biomarkers for Creutzfeldt-Jakob disease (CJD) are established and partly included in the diagnostic criteria, no blood biomarkers are available. Here, we assessed the utility of serum neurofilament light chain (NF-L) and tau protein in comparison to CSF markers (NF-L and phosphorylated NF heavy chain (pNF-H), tau, S100B, 14-3-3) and prion conversion assay (real-time quaking induced conversion (RT-QuIC)) for sporadic and genetic CJD. Importantly, a Gerstmann-Sträussler-Scheinker mutation carrier in the asymptomatic phase and at disease onset was included as well...
December 8, 2016: Scientific Reports
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