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https://www.readbyqxmd.com/read/28437728/is-a-a-o-process-effective-in-toxicity-removal-case-study-with-coking-wastewater
#1
Liu Shi, Dong Wang, Di Cao, Chunhong Na, Xie Quan, Ying Zhang
The anaerobic-anoxic-oxic (A/A/O) process is the commonly used biological wastewater treatment process, especially for the coking wastewater. However, limit is known about its ability in bio-toxicity removal from wastewater. In this study, we evaluated the performance of A/A/O process in bio-toxicity removal from the coking wastewater, using two test species (i.e. crustacean (Daphnia magna) and zebra fish (Danio rerio)) in respect of acute toxicity, oxidative damage and genotoxicity. Our results showed that the acute toxicity of raw influent was reduced gradually along with A/A/O process and the effluent presented no acute toxicity to Daphnia magna (D...
April 21, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28422363/the-occhiolino-occ-mutant-zebrafish-a-model-for-development-of-the-optical-function-in-the-biological-lens
#2
Masamoto Aose, Tor H Linbo, Owen Lawrence, Tadashi Senoo, David W Raible, John I Clark
BACKGROUND: Zebrafish visual function depends on quality optics. An F3 screen for developmental mutations in the zebrafish nervous system was conducted in wild-type (wt) AB zebrafish exposed to 3 mM of N-ethyl-N-nitrosourea (ENU). RESULTS: Mutant offspring, identified in an F3 screen, were characterized by a small pupil, resulting from retinal hypertrophy or hyperplasia and a small lens. Deficits in visual function made feeding difficult after hatching at approximately 5-6 dpf (days post fertilization)...
April 19, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28369860/broad-shifts-in-the-resource-use-of-a-commercially-harvested-fish-following-the-invasion-of-dreissenid-mussels
#3
Shannon A Fera, Michael D Rennie, Erin S Dunlop
Dreissenid mussels -NDASH-including the zebra (Dreissena polymorpha) and quagga (Dreissena rostiformus bugensis) mussel-NDASH- are invasive species known for their capacity to act as ecosystem engineers. They have caused significant changes in the many freshwater systems they have invaded by increasing water clarity, reducing primary productivity, and altering zooplankton and benthic invertebrate assemblages. What is less clear is how their ecosystem engineering effects manifest up the food web to impact higher trophic levels, including fish...
April 2, 2017: Ecology
https://www.readbyqxmd.com/read/28344476/effect-of-pelargonidin-isolated-from-ficus-benghalensis-l-on-phenotypic-changes-in-zebrafish-danio-rerio-embryos
#4
Uday Kundap, Yogini Jaiswal, Rachana Sarawade, Leonard Williams, Mohd Farooq Shaikh
In the present study, the extraction and isolation of Pelargonidin, an anthocyanin compound from stem bark of Ficus benghalensis are described. The study also involves evaluation of the effect of Pelargonidin on phenotypic variations in zebra fish embryos. Extraction and isolation of Pelargonidin were carried out by employing liquid-liquid extraction technique, phytochemical tests, column chromatography, UV and FT-IR. In the zebra fish embryo model, Paclitaxel was employed as a negative control. A series of phenotypic changes in different stages of embryonic development were studied with treatment concentrations of Pelargonidin between 3...
February 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28320082/rosmarinic-acid-plays-a-protective-role-in-the-embryogenesis-of-zebrafish-exposed-to-food-colours-through-its-influence-on-aurora-kinase-a-level
#5
Y Swarnalatha, I S Jerrine Joseph, Tippabathani Jayakrishna
OBJECTIVE: To evaluate the protective nature of the rosmarinic acid from Sphaeranthus amaranthoides during zebra fish embryogenesis. METHODS: Rosmarinic acid was isolated from the S. amaranthoides. An accurate, sensitive and simple LC-MS analysis was performed to determine the rosmarinic acid from S. amaranthoides. In the present study, zebrafish embryos were exposed to crimson red and sunset yellow at a concentration of 0.1 and 0.5mg/l and the effect of these food colours on the levels of aurora kinase A was studied individually...
March 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28288561/coinfection-outcome-in-an-opportunistic-pathogen-depends-on-the-inter-strain-interactions
#6
Hanna Kinnula, Johanna Mappes, Lotta-Riina Sundberg
BACKGROUND: In nature, organisms are commonly coinfected by two or more parasite strains, which has been shown to influence disease virulence. Yet, the effects of coinfections of environmental opportunistic pathogens on disease outcome are still poorly known, although as host-generalists they are highly likely to participate in coinfections. We asked whether coinfection with conspecific opportunistic strains leads to changes in virulence, and if these changes are associated with bacterial growth or interference competition...
March 14, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28254818/e-prostanoid-3-receptor-mediates-sprouting-angiogenesis-through-suppression-of-the-protein-kinase-a-%C3%AE-catenin-notch-pathway
#7
Di Chen, Juan Tang, Qiangyou Wan, Jian Zhang, Kai Wang, Yujun Shen, Ying Yu
OBJECTIVEW: Angiogenesis is a hallmark of embryonic development and various ischemic and inflammatory diseases. Prostaglandin E2 receptor subtype 3 (EP3) plays an important role in pathophysiologic angiogenesis; however, the precise mechanisms remain unknown. Here, we investigated the role of EP3 in zebra fish embryo and mouse retina angiogenesis and evaluated the underlying mechanisms. APPROACH AND RESULTS: The EP3 receptor was highly expressed in the vasculature in both zebra fish embryos and murine fetal retinas...
March 2, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28249594/enhancement-of-scutellarin-oral-delivery-efficacy-by-vitamin-b12-modified-amphiphilic-chitosan-derivatives-to-treat-type-ii-diabetes-induced-retinopathy
#8
Jingnan Wang, Jiayun Tan, Jiahao Luo, Peilin Huang, Wuyi Zhou, Luming Chen, Lingli Long, Li-Ming Zhang, Banghao Zhu, Liqun Yang, David Y B Deng
BACKGROUND: Diabetic retinopathy is the most common complication in diabetic patients relates to high expression of VEGF and microaneurysms. Scutellarin (Scu) turned out to be effective against diabetes related vascular endothelial cell dysfunction. However, its clinical applications have been limited by its low bioavailability. In this study, we formulated and characterized a novel intestinal target nanoparticle carrier based on amphiphilic chitosan derivatives (Chit-DC-VB12) loaded with scutellarin to enhance its bioavailability and then evaluated its therapeutic effect in experimental diabetic retinopathy model...
March 1, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28243233/zebra-fish-lacking-adaptive-immunity-acquire-an-antiviral-alert-state-characterized-by-upregulated-gene-expression-of-apoptosis-multigene-families-and-interferon-related-genes
#9
Pablo García-Valtanen, Alicia Martínez-López, Azucena López-Muñoz, Melissa Bello-Perez, Regla M Medina-Gali, María Del Mar Ortega-Villaizán, Monica Varela, Antonio Figueras, Víctoriano Mulero, Beatriz Novoa, Amparo Estepa, Julio Coll
To investigate fish innate immunity, we have conducted organ and cell immune-related transcriptomic as well as immunohistologic analysis in mutant zebra fish (Danio rerio) lacking adaptive immunity (rag1(-/-)) at different developmental stages (egg, larvae, and adult), before and after infection with spring viremia carp virus (SVCV). The results revealed that, compared to immunocompetent zebra fish (rag1(+/+) ), rag1(-/-) acquired increased resistance to SVCV with age, correlating with elevated transcript levels of immune genes in skin/fins and lymphoid organs (head kidney and spleen)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28192999/intracellular-and-in-vivo-cyanide-mapping-via-surface-plasmon-spectroscopy-of-single-au-ag-nanoboxes
#10
Peiyuan Wang, Yujie Bai, Chi Yao, Xiaomin Li, Lei Zhou, Wenxing Wang, Ahmed Mohamed El-Toni, Jian Zi, Dongyuan Zhao, Lei Shi, Fan Zhang
Cyanide is extremely toxic to organisms but difficult to detect in living biological specimens. Here, we report a new CN(-) sensing platform based on unmodified Au-Ag alloy nanoboxes that etch in the presence of this analyte, yielding a shift in plasmon frequency that correlates with the analyte concentration. Significantly, when combined with dark field microscopy, these particle probes can be used to measure CN(-) concentrations in HeLa cells and in vivo in Zebra fish embryos. The limit of detection (LOD) of the novel method is 1 nM (below the acceptable limit defined by the World Health Organization), and finite-difference time-domain (FDTD) calculations are used to understand the CN(-) induced spectral shifts...
February 8, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28170238/dual-site-fluorescent-probe-for-visualizing-the-metabolism-of-cys-in-living-cells
#11
Yongkang Yue, Fangjun Huo, Peng Ning, Yongbin Zhang, Jianbin Chao, Xiangming Meng, Caixia Yin
Fluorescent probes, as noninvasive tools for visualizing the metabolism of biomolecules, hold great potential to explore their physiological and pathological processes. For cysteine (Cys), however, none of the reported fluorescent probes could image the metabolic processes in living cells. To achieve this goal, we developed a coumarin derivative based on rational design of the dual recognition sites for Cys and its metabolite, SO2. The probe displayed distinct two channels with turn-on fluorescent emission toward Cys and SO2, which were successfully applied for imaging both A549 cells and zebrafish...
February 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28156042/double-strand-dna-breaks-induced-by-paracyclophane-gold-i-complexes
#12
Peter Werner Roesky, Sebastian Bestgen, Carmen Seidl, Thomas Wiesner, Andreas Zimmer, Martina Falk, Beate Köberle, Martina Austeri, Jan Paradies, Stefan Bräse, Ute Schepers
Gold(I) complexes of ClickPhos [2.2]paracyclophane ligands were synthesized in excellent yields and fully characterized by spectroscopic methods as well as X-ray crystallography. The complexes exhibit a rigid ligand backbone and a triazolyl moiety and were systematically studied with respect to their cytotoxic properties. In combination with the ionic complex [(GemPhos)Au(tht)][ClO4] (tht = tetrahydrothiophene), in which the gold(I) atom exhibits a distorted trigonal coordination sphere of two phosphines and a labile tht ligand, their efficiency in cytotoxicity was investigated in HeLa, MCF7, and HCT116 cells as well as in a Zebra fish model...
February 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28129381/comparative-cytogenetics-between-two-important-songbird-models-the-zebra-finch-and-the-canary
#13
Michelly da Silva Dos Santos, Rafael Kretschmer, Carolina Frankl-Vilches, Antje Bakker, Manfred Gahr, Patricia C M O Brien, Malcolm A Ferguson-Smith, Edivaldo H C de Oliveira
Songbird species (order Passeriformes, suborder Oscines) are important models in various experimental fields spanning behavioural genomics to neurobiology. Although the genomes of some songbird species were sequenced recently, the chromosomal organization of these species is mostly unknown. Here we focused on the two most studied songbird species in neuroscience, the zebra finch (Taeniopygia guttata) and the canary (Serinus canaria). In order to clarify these issues and also to integrate chromosome data with their assembled genomes, we used classical and molecular cytogenetics in both zebra finch and canary to define their chromosomal homology, localization of heterochromatic blocks and distribution of rDNA clusters...
2017: PloS One
https://www.readbyqxmd.com/read/28091617/switch-from-sexual-to-parthenogenetic-reproduction-in-a-zebra-shark
#14
Christine L Dudgeon, Laura Coulton, Ren Bone, Jennifer R Ovenden, Severine Thomas
Parthenogenesis is a natural form of asexual reproduction in which embryos develop in the absence of fertilisation. Most commonly found in plants and invertebrate organisms, an increasing number of vertebrate species have recently been reported employing this reproductive strategy. Here we use DNA genotyping to report the first demonstration of an intra-individual switch from sexual to parthenogenetic reproduction in a shark species, the zebra shark Stegostoma fasciatum. A co-housed, sexually produced daughter zebra shark also commenced parthenogenetic reproduction at the onset of maturity without any prior mating...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28075531/three-dimensional-imaging-flow-cytometry-through-light-sheet-fluorescence-microscopy
#15
REVIEW
Emilio J Gualda, Hugo Pereira, Gabriel G Martins, Rui Gardner, Nuno Moreno
Flow cytometry is the tool of choice for high-speed acquisition and analysis of large cell populations, with the tradeoff of lacking intracellular spatial information. Although in the last decades flow cytometry systems that can actually acquire two-dimensional spatial information were developed, some of the limitations remained though, namely constrains related to sample size and lack of depth or dynamic information. The combination of fluidics and light-sheet illumination has the potential to address these limitations...
February 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28043500/design-and-development-of-novel-inhibitors-for-the-treatment-of-latent-tuberculosis
#16
Rudraraju Srilakshmi Reshma, Perumal Yogeeswari, Dharmarajan Sriram
OBJECTIVE/BACKGROUND: "The captain of all these men of death", is the apt sobriquet for the age-old disease tuberculosis (TB). Despite the availability of many drugs, cases of increasing resistance in the forms of multi-drug and extensively drug-resistant TB and persistence [characteristic of Mycobacterium tuberculosis (MTB)] make the eradication of TB a nightmare. Approval of bedaquiline by the Food and Drug Administration focused attention on quinoline scaffolds for development of new anti-TB agents...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28002605/knockdown-of-the-putative-lifeguard-homologue-cg3814-in-neurons-of-drosophila-melanogaster
#17
P G M'Angale, B E Staveley
Lifeguard is an integral transmembrane protein that modulates FasL-mediated apoptosis by interfering with the activation of caspase 8. It is evolutionarily conserved, with homologues present in plants, nematodes, zebra fish, frog, chicken, mouse, monkey, and human. The Lifeguard homologue in Drosophila, CG3814, contains the Bax inhibitor-1 family motif of unknown function. Downregulation of Lifeguard disrupts cellular homeostasis and disease by sensitizing neurons to FasL-mediated apoptosis. We used bioinformatic analyses to identify CG3814, a putative homologue of Lifeguard, and knocked down CG3814/LFG expression under the control of the Dopa decarboxylase (Ddc-Gal4) transgene in Drosophila melanogaster neurons to investigate whether it possesses neuroprotective activity...
December 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27999812/integrative-characterization-of-toxic-response-of-zebra-fish-danio-rerio-to-deltamethrin-based-on-ache-activity-and-behavior-strength
#18
Qing Ren, Tingting Zhang, Shangge Li, Zongming Ren, Meiyi Yang, Hongwei Pan, Shiguo Xu, Li Qi, Tae-Soo Chon
In order to characterize the toxic response of zebra fish (Danio rerio) to Deltamethrin (DM), behavior strength (BS) and muscle AChE activity of zebra fish were investigated. The results showed that the average values of both BS and AChE activity showed a similarly decreased tendency as DM concentration increased, which confirmed the dose-effect relationship, and high and low levels of AChE and BS partly matched low and high levels of exposure concentrations in self-organizing map. These indicated that AChE and BS had slight different aspects of toxicity although overall trend was similar...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27896025/zebra-mussel-beds-an-effective-feeding-ground-for-ponto-caspian-gobies-or-suitable-shelter-for-their-prey
#19
Jarosław Kobak, Małgorzata Poznańska, Łukasz Jermacz, Tomasz Kakareko, Daniel Prądzynski, Małgorzata Łodygowska, Karolina Montowska, Karolina Bącela-Spychalska
Aggregations of the Ponto-Caspian invasive zebra mussel (Dreissena polymorpha) constitute a suitable habitat for macroinvertebrates, considerably increasing their abundance and providing effective antipredator protection. Thus, the overall effect of a mussel bed on particular predator species may vary from positive to negative, depending on both prey density increase and predator ability to prey in a structurally complex habitat. Alien Ponto-Caspian goby fish are likely to be facilitated when introduced into new areas by zebra mussels, provided that they are capable of utilizing mussel beds as habitat and feeding grounds...
2016: PeerJ
https://www.readbyqxmd.com/read/27892606/svep1-plays-a-crucial-role-in-epidermal-differentiation
#20
Liat Samuelov, Qiaoli Li, Ron Bochner, Nicole A Najor, Lauren Albrecht, Natalia Malchin, Tomer Goldsmith, Meital Grafi-Cohen, Dan Vodo, Gilad Fainberg, Benjamin Meilik, Ilan Goldberg, Emily Warshauer, Tova Rogers, Sarah Edie, Akemi Ishida-Yamamoto, Lisa Burzenski, Noam Erez, Steve A Murray, Alan D Irvine, Lenny Shultz, Kathleen J Green, Jouni Uitto, Eli Sprecher, Ofer Sarig
SVEP1 is a recently identified multidomain cell adhesion protein, homologous to the mouse polydom protein, which has been shown to mediate cell-cell adhesion in an integrin-dependent manner in osteogenic cells. In this study, we characterized SVEP1 function in the epidermis. SVEP1 was found by qRT-PCR to be ubiquitously expressed in human tissues, including the skin. Confocal microscopy revealed that SVEP1 is normally mostly expressed in the cytoplasm of basal and suprabasal epidermal cells. Downregulation of SVEP1 expression in primary keratinocytes resulted in decreased expression of major epidermal differentiation markers...
November 28, 2016: Experimental Dermatology
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