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https://www.readbyqxmd.com/read/28534843/three-new-abietane-type-diterpenoids-from-callicarpa-macrophylla-vahl
#1
Zhen-Hui Wang, Chao Niu, De-Jun Zhou, Ji-Chuan Kong, Wen-Kui Zhang
Three new abietane-type diterpenoids, named callicapoic acid M3 (1), callicapoic acid M4 (2) and callicapoic acid M5 (3), were isolated from the Callicarpa macrophylla Vahl. Their structures were established by spectroscopic techniques (IR, UV, MS, 1D and 2D NMR). All the isolated three compounds were evaluated for inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells by using MTT assays. Compounds 1, 2 and 3 showed potent inhibitory activity, with inhibition rates of 34.47-40.13%...
May 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28531166/-epiafzelechin-protects-against-ovariectomy-induced-bone-loss-in-adult-mice-and-modulate-osteoblastic-and-osteoclastic-functions-in-vitro
#2
Ka-Chun Wong, Sisi Cao, Xiaoli Dong, Man-Chun Law, Tak-Hang Chan, Man-Sau Wong
The present study was designed to characterize the bone protective effects of (-)-epiafzelechin (EAF), a flavan-3-ol, in mature ovariectomized mice model and its ability to stimulate osteoblastic activity and inhibit osteoclastic activity. Mature C57BL/6 mice (three to four months old) were either ovariectomised (OVX) or sham-operated and subjected to treatment (vehicle, 17β-oestradiol (E2, 200 μg/kg/day) or EAF (500 μg/kg/day) orally for six weeks. EAF and E2 significantly reduced urinary calcium (Ca) excretion, serum osteocalcin (OCN), and urinary deoxy-pyridinoline (DPD); increased bone mineral density (BMD); and improved micro-architectural properties in OVX mice...
May 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28530806/photoluminescent-hybrids-of-cellulose-nanocrystals-and-carbon-quantum-dots-as-cytocompatible-probes-for-in-vitro-bio-imaging
#3
Jiaqi Guo, Dongfei Liu, Ilari Filpponen, Leena-Sisko Johansson, Jani-Markus Malho, Sakeena Quraishi, Falk Liebner, Hélder A Santos, Orlando J Rojas
We present an approach to construct biocompatible and photoluminescent hybrid materials comprised of carbon quantum dots (CQD) and TEMPO-oxidized cellulose nanocrystals (TO-CNC). First, the amino-functionalized carbon quantum dots (NH2-CQD) were synthesized using a simple microwave method and the TO-CNCs were prepared by hydrochloric acid (HCl) hydrolysis followed by TEMPO-mediated oxidation. The conjugation of NH2-CQD and TO-CNC was conducted via carbodiimide-assisted coupling chemistry. The synthesized TO-CNC@CQD hybrid nanomaterials were characterized using X-ray photoelectron spectroscopy, cryo-transmittance electron microscopy, confocal microscopy and fluorescence spectroscopy...
May 22, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28529485/hydrostatin-sn1-a-sea-snake-derived-bioactive-peptide-reduces-inflammation-in-a-mouse-model-of-acute-lung-injury
#4
Guosheng Wu, Junjie Wang, Pengfei Luo, An Li, Song Tian, Hailong Jiang, Yongjun Zheng, Feng Zhu, Yiming Lu, Zhaofan Xia
Snake venom has been used for centuries as a traditional Chinese medicine. Hydrostatin-SN1 (H-SN1), a bioactive peptide extracted from the Hydrophis cyanocinctus venom gland T7 phage display library, was reported to have the ability to reduce inflammation in a dextran sulfate sodium-induced murine colitis model. In this study, we sought to investigate the inhibitory potential of H-SN1 on inflammation in a murine model of lipopolysaccharide (LPS)-induced acute lung injury (ALI), and elucidate the anti-inflammatory mechanism in LPS-stimulated RAW 264...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28529178/anti-inflammatory-activities-of-compounds-from-twigs-of-morus-alba
#5
Huynh Nguyen Khanh Tran, Van Thu Nguyen, Jeong Ah Kim, Seong Soo Rho, Mi Hee Woo, Jae Sui Choi, Jeong-Hyung Lee, Byung Sun Min
Five new compounds, 10-oxomornigrol F (1), (7″R)-(-)-6-(7″-hydroxy-3″,8″-dimethyl-2″,8″-octadien-1″-yl)apigenin (2), ramumorin A (3), ramumorin B (4), and (4S,7S,8R)-trihydroxyoctadeca-5Z-enoic acid (5), together with 31 known compounds (6-36), were isolated from the twigs of Morus alba (Moraceae). The chemical structures of these compounds were established using spectroscopic analyses, 1D and 2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and Mosher's methods. The anti-inflammatory activities of the compounds were evaluated by investigating their ability to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production in macrophage RAW 264...
May 18, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28524774/cytotoxicity-and-anti-leishmania-amazonensis-activity-of-citrus-sinensis-leaf-extracts
#6
Andreza R Garcia, Ana Claudia F Amaral, Mariana M B Azevedo, Suzana Corte-Real, Rosana C Lopes, Celuta S Alviano, Anderson S Pinheiro, Alane B Vermelho, Igor A Rodrigues
CONTEXT: Leishmania amazonensis is the main agent of diffuse cutaneous leishmaniasis, a disease characterized by lesional polymorphism and the commitment of skin surface. Previous reports demonstrated that the Citrus genus possess antimicrobial activity. OBJECTIVE: This study evaluated the anti-L. amazonensis activity of Citrus sinensis (L.) Osbeck (Rutaceae) extracts. MATERIALS AND METHODS: Citrus sinensis dried leaves were subjected to maceration with hexane (CH), ethyl acetate (CEA), dichloromethane/ethanol (CD/Et - 1:1) or ethanol/water (CEt/W - 7:3)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28524200/isolation-of-a-novel-bioactive-protein-from-an-edible-mushroom-pleurotus-eryngii-and-its-anti-inflammatory-potential
#7
Biao Yuan, Liyan Zhao, Kanyasiri Rakariyatham, Yanhui Han, Zili Gao, Benard Muinde Kimatu, Qiuhui Hu, Hang Xiao
Edible mushrooms are rich sources of bioactive components. In this study, a bioactive protein, PEP, was isolated from an edible mushroom, Pleurotus eryngii, through (NH4)2SO4 precipitation and ion-exchange chromatography. Proteomic analysis by matrix assisted laser desorption ionization-time of flight mass spectrometry showed that PEP was a novel protein with a molecular weight of 40 kDa. PEP exhibited anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by inhibiting the overproduction of pro-inflammatory mediators including nitric oxide (NO), cytokine IL-1β and IL-6...
May 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28516508/near-infrared-photodynamic-inactivation-of-s-pneumoniae-and-its-interaction-with-raw-264-7-macrophages
#8
Ilaiáli S Leite, Mariana C Geralde, Ana C G Salina, Alexandra I Medeiros, Lívia N Dovigo, Vanderlei S Bagnato, Natalia M Inada
Pneumonia is the main cause of children mortality worldwide, and its major treatment obstacle stems from the microorganisms increasing development of resistance to several antibiotics. Photodynamic therapy has been presenting, for the last decades, promising results for some subtypes of cancer and infections. In this work we aimed to develop a safe and efficient in vitro protocol for photodynamic inactivation of Streptococcus pneumoniae, one of the most commonly found bacteria in pneumonia cases, using two near-infrared light sources and indocyanine green, a FDA approved dye...
May 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28514148/hirsutane-type-sesquiterpenes-with-inhibitory-activity-of-microglial-nitric-oxide-production-from-the-red-alga-derived-fungus-chondrostereum-sp-ntou4196
#9
George Hsiao, Wei-Chiung Chi, Ka-Lai Pang, Jih-Jung Chen, Yueh-Hsiung Kuo, Yu-Kai Wang, Hyo-Jung Cha, Shen-Chieh Chou, Tzong-Huei Lee
The marine red alga Pterocladiella capillacea is an economic alga for the food industry in Taiwan, and its associated highly diversified fungi have not been investigated meticulously thus far. The EtOAc extract of the fermented broth of Chondrostereum sp. NTOU4196, a fungal strain isolated from P. capillacea, was found to exhibit significant nitric oxide (NO) production inhibitory activity in lipopolysaccharide-activated murine RAW 264.7 cells at a concentration of 100 μg/mL in the preliminary screening. Therefore, separation of the active principles from the fermented broths was performed, and that has led to the isolation of eight new 5,5,5-tricyclic hirsutane-type sesquiterpenes, namely, chondroterpenes A-H (1-8), together with seven known analogues...
May 17, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28513563/new-glycosides-from-the-fruits-of-nicandra-physaloides
#10
Yan Liu, Hai-Bing Jiang, Zhen-Peng Xu, Yan-Gang Cheng, Shao-Wa Lv, Bing-You Yang, Hong-Wei Guo, Hai-Xue Kuang
Three new glycosides (1-3) and 15 known ones (4-18) were isolated and identified from the fruits of Nicandra physaloides. The structures of these compounds were established by 1D and 2D NMR spectra and HR-ESI-MS. The compounds (4-18) were the first time isolated from the Nicandra genus and they (except 8, 10, 14) exhibited inhibitions on the NO release of LPS-induced RAW 264.7 cells with IC50 values from 26.9 to 47.5 μM.
May 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28513174/structure-and-activity-relationship-of-curcumin-role-of-methoxy-group-in-anti-inflammatory-and-anti-colitis-effects-of-curcumin
#11
Haixia Yang, Zheyuan Du, Weicang Wang, Mingyue Song, Katherine Z Sanidad, Elvira Sukamtoh, Jennifer Zheng, Li Tian, Hang Xiao, Zhenhua Liu, Guodong Zhang
Curcumin, a dietary compound from Turmeric, has beneficial effects on inflammatory diseases such as inflammatory bowel disease. While most previous studies have focused on structure-activity relationship of the thiol-reactive α, β-unsaturated carbonyl groups of curcumin, little is known about the roles of methoxy groups in biological activities of curcumin. Here we synthesized a series of curcumin analogs with different substitution groups (R = H-, Br-, Cl-, F-, NO2-, CH3-, and OH-) to replace the methoxy group, and evaluated their biological effects in vitro and in vivo...
May 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28510430/nanoarchitecturing-of-natural-melanin-nanospheres-by-layer-by-layer-assembly-macroscale-anti-inflammatory-conductive-coatings-with-optoelectronic-tunability
#12
Taesik Eom, Kyungbae Woo, Whirang Cho, Jaeeun Heo, Daseul Jang, Jae In Shin, David Charles Martin, Jeong Jae Wie, Bong Sup Shim
Natural melanins are biocompatible conductors with versatile functionalities. Here, we report fabrication of multifunctional poly(vinyl alcohol)/melanin nanocomposites by layer-by-layer (LBL) assembly using melanin nanoparticles (MNPs) directly extracted from sepia officinalis inks. The LBL assembly offers facile manipulation of nanotextures as well as nm-thickness control of the macroscale film by varying solvent qualities. The time-resolved absorption was monitored during the process and quantitatively studied by fractal dimension and lacunarity analysis...
May 16, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28509410/anti-inflammatory-anti-osteoclastic-and-antioxidant-activities-of-genistein-protect-against-alveolar-bone-loss-and-periodontal-tissue-degradation-in-a-mouse-model-of-periodontitis
#13
Govinda Bhattarai, Sher Bahadur Poudel, Sung-Ho Kook, Jeong-Chae Lee
Genistein, a dietary polyphenol primarily found in soy products, has beneficial effects on bone. However, the effect of genistein on inflammatory periodontal destruction has not been investigated in detail. We explored whether genistein protects against lipopolysaccharide (LPS)/ligature-induced periodontitis in mice. We also examined the effect of genistein on LPS-stimulated inflammatory and oxidative stress using RAW 264.7 macrophages and human gingival fibroblasts (hGFs). The results from μCT and histological analyses revealed that intraperitoneal injection of genistein (20 mg/kg body weight) daily for three weeks inhibited LPS-mediated alveolar bone loss and periodontal tissue degradation...
May 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28506901/new-isoflavonoids-from-the-extract-of-rhynchosia-precatoria-humb-bonpl-ex-willd-dc-and-their-antimycobacterial-activity
#14
Enrique Wenceslao Coronado-Aceves, Giulia Gigliarelli, Adriana Garibay-Escobar, Ramón Enrique Robles Zepeda, Massimo Curini, Jaime López Cervantes, Clara Inés Espitia-Pinzón, Stefano Superchi, Stefania Vergura, Maria Carla Marcotullio
ETHNOPHARMACOLOGY RELEVANCE: The evaluation of the antimycobacterial activity of extracts of medicinal plants used by Mayos against tuberculosis and respiratory problems, allowed the identification of Rhynchosia precatoria (Humb. & Bonpl. ex Willd.) DC (Fabaceae) as the best candidate to find new antimycobacterial compounds. AIM OF THE STUDY: To isolate and characterize the compounds of R. precatoria responsible for the inhibitory and bactericidal activity against Mycobacterium tuberculosis H37Rv and Mycobacterium smegmatis ATCC 700084...
May 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28504466/nepetoidin-b-a-natural-product-inhibits-lps-stimulated-nitric-oxide-production-via-modulation-of-inos-mediated-by-nf-%C3%AE%C2%BAb-mkp-5-pathways
#15
Xiaxia Wu, Hongwei Gao, Wen Sun, Jie Yu, Hao Hu, Qiongming Xu, Xiuping Chen
Previous reports showed that nepetoidin B (NTB), a natural product isolated from many herbs, has anti-fungal and anti-bacterial effects. In this study, the antiinflammatory effect of NTB was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The cytotoxic effect of NTB and LPS was determined by MTT assay. The nitric oxide (NO) production was detected by Griess assay. The TNF-α and IL-6 levels were determined by enzyme-linked immunosorbent assay kits. Protein expressions were tested by western blotting...
May 15, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28504179/immunomodulatory-effects-of-xanthan-gum-in-lps-stimulated-raw-264-7-macrophages
#16
Fuyan Liu, Xiaofeng Zhang, Peixue Ling, Joshua Liao, Mingsheng Zhao, Li Mei, Huarong Shao, Peng Jiang, Zhigang Song, Qixin Chen, Fengshan Wang
In this study, we evaluated the immunomodulatory effects of xanthan gum (XG) in RAW264.7 macrophages and the underlying molecular mechanisms. We used scanning electron microscopy (SEM) to analyze the morphology of XG-treated RAW264.7 cells with and without lipopolysaccharide (LPS) stimulation and investigated the subsequent effects on nitric oxide (NO), interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor (TNF-α), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) levels in LPS-activated mouse RAW264...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28504149/post-screening-characterisation-and-in-vivo-evaluation-of-an-anti-inflammatory-polysaccharide-fraction-from-eucommia-ulmoides
#17
Qiu Li, Yanxian Feng, Wei He, Lintao Wang, Ruibing Wang, Lei Dong, Chunming Wang
We report here the discovery of a polysaccharide, namely EUP1, with anti-inflammatory activity from the herb of Eucommia ulmoides Oliv. We separated three polysaccharide fractions from this herb based on acidity and screened them for their activity in modulating the phenotype of murine macrophages. Among them, EUP1 was the only fraction to exert such a function - it stimulated Raw 264.7 cells to express CD206 and a key anti-inflammatory cytokine interleukin-10. Having fully characterised EUP1 with a series of chromatographic and spectroscopic analyses, we evaluated its anti-inflammatory effects in both in vitro and in vivo inflammatory models...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28502116/phenolic-composition-anti-inflammatory-antioxidant-and-antimicrobial-activities-of-alchemilla-mollis-buser-rothm
#18
Gökçe Şeker Karatoprak, Selen İlgün, Müberra Koşar
The current study was designed to evaluate the antioxidant, anti-inflammatory and antimicrobial activities of Alchemilla mollis (Buser) Rothm. (Rosaceae) aerial parts extracts. Chemical composition was analyzed by spectrophotometric and chromatographic (HPLC) techniques. The antioxidant properties assessed included, DPPH(●) and ABTS(●+) radical scavenging, β-carotene-linoleic acid co-oxidation assay. Antimicrobial activity was evaluated with disc diffusion and micro dilution method. In order to evaluate toxicity of the extracts with the sulforhodamine B (SRB) colorimetric assay L929 cell line (mouse fibroblast) was used...
May 14, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28499733/alkaloids-from-aerial-parts-of-houttuynia-cordata-and-their-anti-inflammatory-activity
#19
Jongmin Ahn, Hee-Sung Chae, Young-Won Chin, Jinwoong Kim
New alkaloids, houttuynamide B and C (1, 2) and houttuycorine (14), were isolated from the aerial parts of Houttuynia cordata Thunb. in addition to eighteen known alkaloids. Their structures were elucidated through extensive spectroscopic analysis. All the isolates were tested for their inhibitory activity against NO production in RAW 264.7 cells stimulated by LPS. Of the tested compounds, compound 15 showed the most potent anti-inflammatory activity with an IC50 value of 8.7μM.
April 26, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28498622/regulation-of-raw264-7-macrophage-polarization-on-smooth-and-rough-surface-topographies-by-galectin-3
#20
F Kianoush, M Nematollahi, J D Waterfield, D M Brunette
Recognition of topographical features induces phenotypic changes in macrophages although the receptors and signaling pathways are not completely characterized. As integrin molecules in focal adhesions/podosomes are in intimate contact with topography and topography modulates the NFkB pathway through cholesterol enriched raft-associated adhesive signaling structures we hypothesized that a cell-surface signaling complex comprised of galectin-3 together with its ligand CD98 and integrinβ1 is important for topography-directed lineage determination...
May 12, 2017: Journal of Biomedical Materials Research. Part A
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