keyword
MENU ▼
Read by QxMD icon Read
search

Raw 264.7

keyword
https://www.readbyqxmd.com/read/28335395/essential-oil-composition-and-bioactivities-of-waldheimia-glabra-asteraceae-from-qinghai-tibet-plateau
#1
Ji De, Yan Lu, Lijun Ling, Nan Peng, Yang Zhong
Waldheimia glabra is traditionally used as incense and as an anti-influenza drug by Tibetans in China. Here, we collected W. glabra from the Gangs Rinpoche mountain at an altitude of 5200 m, and analyzed its essential oil by gas chromatography-mass spectrometry (GC-MS) combined with the retention indices (RI). Twenty-seven compounds, representing 72.4% of the total essential oil, were identified, including α-bisabolol (20.2%), valeranone (11.8%), chamazulene (9.9%), spathulenol (8.2%), β-caryophyllene (6...
March 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28333090/biscembranoids-and-cembranoids-from-the-soft-coral-sarcophyton-elegans
#2
Wei Li, Yi-Hong Zou, Man-Xi Ge, Lan-Lan Lou, Yun-Shao Xu, Abrar Ahmed, Yun-Yun Chen, Jun-Sheng Zhang, Gui-Hua Tang, Sheng Yin
Two novel biscembranoids, sarelengans A and B (1 and 2), five new cembranoids, sarelengans C-G (3-7), along with two known cembranoids (8 and 9) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 were confirmed by single crystal X-ray diffraction. Compounds 1 and 2 represent the first example of biscembranoids featuring a trans-fused A/B-ring conjunction between the two cembranoid units. Their unique structures may shed light on an unusual biosynthetic pathway involving a cembranoid-∆⁸ rather than the normal cembranoid-∆¹ unit in the endo-Diels-Alder cycloaddition...
March 23, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28332697/alpha-1-antitrypsin-inhibits-rankl-induced-osteoclast-formation-and-functions
#3
Mohammad Ahsanul Akbar, David Nardo, Mong-Jen Chen, Ahmed S Elshikha, Rubina Ahamed, Eslam M Elsayed, Claire Bigot, Lexie Shannon Holliday, Sihong Song
Osteoporosis is a global public health problem affecting more than 200 million people worldwide. We previously showed that treatment with alpha-1 antitrypsin (AAT), a multifunctional protein with anti-inflammatory properties, mitigated bone loss in an ovariectomized mouse model. However, the underlying mechanisms of the protective effect of AAT on bone tissue are largely unknown. In this study, we investigated the effect of AAT on osteoclast formation and function in vitro. Our results showed that AAT dose-dependently inhibited the formation of RANKL (receptor activator of nuclear factor κB ligand) induced osteoclasts derived from mouse bone marrow macrophages/monocyte (BMM) lineage cells and the murine macrophage cell line, RAW 264...
March 21, 2017: Molecular Medicine
https://www.readbyqxmd.com/read/28327520/cytotoxicity-bactericidal-and-antioxidant-activity-of-sodium-alginate-hydrosols-treated-with-direct-electric-current
#4
Żaneta Król, Krzysztof Marycz, Dominika Kulig, Monika Marędziak, Andrzej Jarmoluk
The aim of the study was to investigate the effect of using direct electric current (DC) of 0, 200, and 400 mA for five minutes on the physiochemical properties, cytotoxicity, antibacterial, and antioxidant activity of sodium alginate hydrosols with different sodium chloride concentrations. The pH, oxidation-reduction potential (ORP), electrical conductivity (EC), and available chlorine concentration (ACC) were measured. The effect of sodium alginate hydrosols treated with DC on Staphylococcus aureus, Listeria monocytogenes, Bacillus cereus, Micrococcus luteus, Escherichia coli, Salmonella enteritidis, Yersinia enterocolitica, Pseudomonas fluorescence, and RAW 264...
March 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28322382/regulation-of-raw-264-7-cell-mediated-immunity-by-polysaccharides-from-agaricus-blazei-murill-via-the-mapk-signal-transduction-pathway
#5
Feier Cheng, Xiaoyan Yan, Miaoqing Zhang, Mingchang Chang, Shaojun Yun, Junlong Meng, Jingyu Liu, Cui-Ping Feng
Agaricus blazei Murill (ABM) is a common anticancer folk remedy. Its active ingredients, i.e., polysaccharides, have been isolated and exhibit indirect tumor-suppressing activity via immunological activation. The effects of polysaccharides derived from A. blazei Murill (ABMP) on RAW 264.7 cells were examined by western blotting and real-time reverse transcription polymerase chain reaction (RT-PCR). The effects of 500, 1000, and 2000 μg mL(-1) ABMP on the growth of RAW 264.7 cells were evaluated by measuring the OD490 value; the optimum concentration was found to be 1000 μg mL(-1)...
March 21, 2017: Food & Function
https://www.readbyqxmd.com/read/28317731/encapsulation-of-sesamol-in-phosphatidyl-choline-micelles-enhanced-bioavailability-and-anti-inflammatory-activity
#6
P S Yashaswini, Nawneet K Kurrey, Sridevi A Singh
Sesamol, the phenolic degradation product of sesamolin, although recognised for its anti-inflammatory effects, has low bioavailability. In this manuscript, we attempted to improve its bioavailability by encapsulation in mixed phosphatidylcholine micelles. Sesamol could be solubilised and entrapped in phosphatidylcholine mixed micelles (PCS) with 96.8% efficiency (particle size 3.0±0.06nm). Fluorescence spectra of PCS revealed lower relative fluorescence intensity (RFI 112) compared to 'free' sesamol (FS) (RFI 271)...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28316418/seroepidemiology-of-toxoplasma-gondii-infection-in-pregnant-women-in-west-iran-determined-by-elisa-and-pcr-analysis
#7
Gholam Reza Ahmadpour, Behrouz Ezatpour, Ramtin Hadighi, Hormoz Oormazdi, Lame Akhlaghi, Fatemeh Tabatabaei, Mehdi Azami, Mozafar Mohammadi Nejad, Hossein Mahmoudvand
Congenital toxoplasmosis can lead to severe damage for the fetus and newborn. Considering that the seroepidemiology of Toxoplasma infection in the pregnant women is poorly studied in west of Iran, the main objective of this study was to estimate the seroprevalence and potential risk factors for congenital toxoplasmosis in Delfan, Iran. In this cross-sectional study, the serum samples obtained from pregnant women who were referred to health centers for routine monitoring of the pregnancy. Totally, 264 sera were screened for IgG and IgM anti-T...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28316375/torilin-inhibits-inflammation-by-limiting-tak1-mediated-map-kinase-and-nf-%C3%AE%C2%BAb-activation
#8
Mehari Endale, Tae-Hwan Kim, Yi-Seong Kwak, Na-Mi Kim, Seung-Hyung Kim, Jae Youl Cho, Bong-Sik Yun, Man-Hee Rhee
Torilin, a sesquiterpene isolated from the fruits of Torilis japonica, has shown antimicrobial, anticancer, and anti-inflammatory properties. However, data on the mechanism of torilin action against inflammation is limited. This study aimed at determining the anti-inflammatory property of torilin in LPS-induced inflammation using in vitro model of inflammation. We examined torilin's effect on expression levels of inflammatory mediators and cytokines in LPS-stimulated RAW 264.7 macrophages. The involvement of NF-kB and AP-1, MAP kinases, and adaptor proteins were assessed...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28315458/cyperus-rotundus-l-extract-suppresses-rankl-induced-osteoclastogenesis-through-nfatc1-c-fos-downregulation-and-prevent-bone-loss-in-ovx-induced-osteoporosis-rat
#9
Chang-Jun Kum, Eun-Young Kim, Jae-Hyun Kim, Bina Lee, Ju-Hee Min, Jun Heo, Jong-Hyun Kim, Mijung Yeom, Youngjoo Sohn, Hyuk-Sang Jung
ETHNOPHARMACOLOGICAL RELEVANCE: Cyperus Rotundus L. (CyR) has been widely used for the treatment of gynecologic disorder. Recent studies have reported that CyR can prevent the formation of cystic follicles and ovarian malfunction. However, the effects of CyR on osteoclastogenesis and postmenopausal osteoporosis remain unknown. AIM OF THE STUDY: This study was aimed to investigate the preventive effects of CyR on RANKL-induced osteoclast formation and ovariectomy (OVX)-induced bone loss...
March 15, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28315350/irisin-acts-as-a-regulator-of-macrophages-host-defense
#10
Agnieszka Irena Mazur-Bialy
AIM: Irisin, the adipomyokine, released mainly by exercised muscles, participate in the browning of adipose tissue and contribute to the restriction of insulin resistance and diabetes mellitus 2 development. Because of the limited reports describing the effect of irisin on inflammation and immunocompetent cells activation, the present study attempted to assess the influence of various irisin concentrations on basic macrophage activity. MAIN METHODS: Studies were carried out on murine RAW 264...
March 14, 2017: Life Sciences
https://www.readbyqxmd.com/read/28314223/gv1001-immunotherapy-ameliorates-joint-inflammation-in-a-murine-model-of-rheumatoid-arthritis-by-modifying-collagen-specific-t-cell-responses-and-downregulating-antigen-presenting-cells
#11
In Ah Choi, Ji Yong Choi, Sundo Jung, Fathihah Basri, Seho Park, Eun Young Lee
This study investigated whether GV1001 may be useful for treating rheumatoid arthritis (RA). Two collagen-induced arthritis (CIA) experiments showed that therapeutic, but not preventive, GV1001 treatment reduced the severity of joint inflammation in CIA. The third CIA experiment indicated that, compared to vehicle treatment, therapeutic GV1001 treatment was associated with a significantly smaller area under the curve for the overall clinical joint score over the 98day observation period (p<0.05). GV1001 treatment was also associated with lower Day 98 serum IL-6 levels (p<0...
March 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28304345/briarenols-c-e-new-polyoxygenated-briaranes-from-the-octocoral-briareum-excavatum
#12
Nan-Fu Chen, Yin-Di Su, Tsong-Long Hwang, Zuo-Jian Liao, Kuan-Hao Tsui, Zhi-Hong Wen, Yang-Chang Wu, Ping-Jyun Sung
Three new polyoxygenated briarane diterpenoids, briarenols C-E (1-3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1-3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1 was found to exist in a twisted boat conformation. Briarenol D (2) displayed an inhibitory effect on the release of elastase by human neutrophils with an IC50 value of 4.65 μM. Briarenol E (3) was found to inhibit the protein expression of pro-inflammatory inducible nitric oxide synthase (iNOS) in a murine macrophage-like cell line, RAW 264...
March 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28303957/astragalus-polysaccharides-exerts-immunomodulatory-effects-via-tlr4-mediated-myd88-dependent-signaling-pathway-in-vitro-and-in-vivo
#13
Lijing Zhou, Zijing Liu, Zhixue Wang, Shuang Yu, Tingting Long, Xing Zhou, Yixi Bao
Astragalus polysaccharides (APS), which is widely used as a remedy to promote immunity of breast cancer patients, can enhance immune responses and exert anti-tumor effects. In this study, we investigated the effects and mechanisms of APS on macrophage RAW 264.7 and EAC tumor-bearing mice. Griess reaction and ELISA assays revealed that the concentrations of nitric oxide, TNF-α, IL-1β and IL-6 were increased by APS. However, this effect was diminished in the presence of TAK-242 (TLR4 inhibitor) or ST-2825(MyD88 inhibitor)...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28302488/protective-effects-of-zn-2-against-cobalt-nanoparticles-and-cobalt-chloride-induced-cytotoxicity-of-raw-264-7cells-via-ros-pathway
#14
Hai Zhu, Yake Liu, Hongxiang Hong, Wei Wang, Fan Liu
Recent concerns have emerged surrounding the toxicity that cobalt may represent when used in MOM implants. Owing to corrosion and wear of MOM implants, the subsequent released cobalt nanoparticles (CoNPs) or Co ions (Co(2+)) can cause adverse reactions, such as the generation of pseudotumors, extensive necrosis, early osteolysis, and implants failure. The present study confirmed that CoNPs and Co(2+) can induce dose- and time-dependent cytotoxicity with increasing reactive oxygen species (ROS) levels. Additionally, using metallothionein (MT), a heavy metal-binding protein, the present study assessed the protective effects of Zn(2+) against CoNPs and Co(2+)-induced cytotoxicity of RAW 264...
March 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28300703/highly-oxygenated-lanostane-type-triterpenoids-and-their-bioactivity-from-the-fruiting-body-of-ganoderma-gibbosum
#15
De-Bing Pu, Xi Zheng, Jun-Bo Gao, Xing-Jie Zhang, Yan Qi, Xiao-Si Li, Yong-Mei Wang, Xiao-Nian Li, Xiao-Li Li, Chun-Ping Wan, Wei-Lie Xiao
Eight new highly oxygenated lanostane triterpenes, gibbosic acids A-H (1-8), along with three known ones (9-11), were isolated from the fruiting body of Ganoderma gibbosum. The structures of new isolates were assigned by NMR and HRESIMS experiments. The absolute configurations of 1 were further confirmed by single crystal X-ray diffraction data and computational ECD methods. Immunoregulatory effect and anti-inflammatory activities of these compounds were screened in murine lymphocyte proliferation assay and in lipopolysaccharide (LPS)-stimulated RAW-264...
March 11, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28299311/immunostimulated-arginase-ii-expression-in-intestinal-epithelial-cells-reduces-nitric-oxide-production-and-apoptosis
#16
Maria M Talavera, Sushma Nuthakki, Hongmei Cui, Yi Jin, Yusen Liu, Leif D Nelin
Increased production of nitric oxide (NO) and subsequent local cytotoxicity to mucosal epithelial cells has been proposed as a putative mechanism involved in the development of necrotizing enterocolitis (NEC). Intestinal epithelial cells (IECs) metabolize L-arginine to either nitric oxide (NO) by NO synthase (NOS) or to L-ornithine and urea by arginase. L-ornithine is the first step in polyamine synthesis important for cell proliferation, while NO production can lead to apoptosis. We hypothesized that in IECs immunostimulation increases both NOS and arginase expression, and that arginase activity mitigates NO production and apoptosis...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28298071/protective-effect-of-dracontium-dubium-against-bothrops-asper-venom
#17
Daneiva Caro, Yanet Ocampo, Jenny Castro, Lia Barrios, Rubén Salas, Luis A Franco
In Colombia, Bothrops asper is responsible for 70-90% of ophidians accidents reported annually. Envenoming occurs mainly in rural areas where both antivenom and health centers are scarce. Thus, patients are frequently treated by local healers that employ medicinal herbs; including several species belonging to Dracontium genus. In this work, we evaluated the neutralizing activity of Dracontium dubium Kunth against the lethal, inflammatory, coagulant and hemolytic effects produced by B. asper venom. Mice treated with D...
March 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28292183/n-docosahexaenoyl-dopamine-an-endocannabinoid-like-conjugate-of-dopamine-and-the-n-3-fatty-acid-docosahexaenoic-acid-attenuates-lipopolysaccharide-induced-activation-of-microglia-and-macrophages-via-cox-2
#18
Ya Wang, Pierluigi Plastina, Jean-Paul Vincken, Renate Jansen, Michiel Balvers, Jean Paul Ten Klooster, Harry Gruppen, Renger Witkamp, Jocelijn Meijerink
Several studies indicate that the n-3 long-chain polyunsaturated fatty acid docosahexaenoic acid (DHA) contributes to an attenuated inflammatory status in the development of neurodegenerative disorders, such as Alzheimer's and Parkinson's disease. To explain these effects, different mechanisms are being proposed, including those involving endocannabinoids and related signaling molecules. Many of these compounds belong to the fatty acid amides, conjugates of fatty acids with biogenic amines. Conjugates of DHA with ethanolamine or serotonin have previously been shown to possess anti-inflammatory and potentially neuroprotective properties...
March 15, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28292010/the-anti-allergic-and-anti-inflammatory-effects-of-benjakul-extract-a-thai-traditional-medicine-its-constituent-plants-and-its-some-pure-constituents-using-in-vitro-experiments
#19
Sunita Makchuchit, Ruchilak Rattarom, Arunporn Itharat
Benjakul (BJK), a Thai traditional medicine preparation, has long been used for balanced health, controlled abnormal of element in the body, carminative, and relief of flatulence. It is composed of five plants: Piper interruptum Opiz., Piper longum L., Piper sarmentosum Roxb., Plumbago indica L., and Zingiber officinale Roscoe. The ethanolic extracts of BJK, its five individual plants, and pure constituents of BJK were investigated for their anti-allergic activity using immunoglobulin E (IgE)-sensitized β-hexosaminidase in the rat basophilic leukemia-2H3 (RBL-2H3) cells and anti-inflammatory activity using lipopolysaccharide (LPS)-induced nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α) in the murine macrophage (RAW 264...
March 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28291852/osteoclastic-response-on-titanium-surfaces-in-modified-simulated-body-fluid
#20
Moon-Hyoung Kim, Su-Young Lee, Seong-Joo Heo, Seong-Kyun Kim, Myung-Joo Kim, Jai-Young Koak
PURPOSE: It was hypothesized that calcium phosphate (CaP) deposition onto Ti surfaces using biomimetic deposition contributed to not only improving osteogenesis but also suppressing osteoclastogenesis in terms of high surface hydrophilicity. MATERIALS AND METHODS: Ti discs with two different surfaces were prepared: machined and anodic oxidized surfaces. The specimens of two different surfaces were soaked in modified simulated body fluid solution for 14 days at physiologic condition...
March 2017: International Journal of Oral & Maxillofacial Implants
keyword
keyword
80317
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"