keyword
https://read.qxmd.com/read/38454872/hospital-corneal-retrieval-program-a-long-way-to-go
#21
JOURNAL ARTICLE
Anu Jain, Snigdha Sen, Prerna Upadhyay, Nishi Dwivedi, Lokesh K Singh, Renu Agrawal, Sarvesh Kumar
PURPOSE: The Hospital Corneal Retrieval Program (HCRP) aims to counsel and encourage the family of a critically ill or deceased person in the hospital for eye donation. Adequately sensitized health-care workers (HCWs) may play a pivotal role in boosting HCRP. STUDY DESIGN: Multicentric, cross-sectional, descriptive study. METHODS: Study participants included all HCWs of three medical colleges, including one with eye bank and corneal transplant services...
March 8, 2024: Indian Journal of Ophthalmology
https://read.qxmd.com/read/38454864/the-expanding-roles-of-eye-banks-in-india-past-present-and-future
#22
JOURNAL ARTICLE
Sunita Chaurasia, Rohit Dureja, Arvind Roy, Sujata Das
This review highlights the evolution in the scope of eye banking activities in India. The roles and responsibilities of the eye banks have expanded to match the requirements and necessities that arose because of advancements in keratoplasty techniques and the need for corneal surgeons. Adoption of different types of corneal preservation solutions and methods of donor cornea preservation was a consequence of the changing and unprecedented times. The growth of eye banking in India has been a commendable journey and has placed the country in an "almost sufficient" category in eye banking and corneal transplantation...
March 8, 2024: Indian Journal of Ophthalmology
https://read.qxmd.com/read/38451687/amniotic-membrane-transplantation-for-neurotrophic-corneal-ulcers
#23
JOURNAL ARTICLE
Anna Carolina Badotti Linhares, Ana Caroline Martinelli, Mariela Regina Dalmarco Ghem, Paula Basso Dias, Daniel Wasilewski
PURPOSE: To evaluate the clinical results of cryopreserved amniotic membrane transplantation as a treatment option for refractory neurotrophic corneal ulcers. METHODS: This prospective study included 11 eyes of 11 patients who underwent amniotic membrane transplantation for the treatment of refractory neurotrophic corneal ulcers at Hospital de Clínicas da Universidade Federal do Paraná, in the city of Curitiba, from May 2015 to July 2021. Patients underwent different surgical techniques in which the amniotic membrane was applied with the epithelium facing upward to promote corneal re-epithelialization...
2024: Arquivos Brasileiros de Oftalmologia
https://read.qxmd.com/read/38451684/wet-bio-amniotic-membrane-plugging-combined-with-transplantation-in-the-treatment-of-small-corneal-perforations
#24
JOURNAL ARTICLE
Yingxin Chen, Chenxi Lv, Minghong Gao, Zhiling Liu, Ruiyao Gao
PURPOSE: Wet bio-amniotic membrane plugging combined with transplantation is a novel option that combined amniotic membrane plugging with amniotic membrane transplantation for the treatment of small corneal perforations. This study aimed to evaluate the efficacy of wet bio-amniotic membrane plugging in the treatment of small corneal perforations and compared it with that of the penetrating keratoplasty procedure. METHODS: Forty patients (41 eyes) with small corneal perforations <3 mm in diameter treated at our hospital between July 2018 and January 2021 were retrospectively included...
2024: Arquivos Brasileiros de Oftalmologia
https://read.qxmd.com/read/38450471/-intracorneal-selective-stromal-transplantation
#25
JOURNAL ARTICLE
O G Oganesyan, D A Gusak, P V Makarov, P M Ashikova
UNLABELLED: Deep anterior lamellar keratoplasty or penetrating keratoplasty are currently considered the optimal methods of surgical treatment of stromal dystrophies and corneal degeneration. Despite certain advantages and benefits of these methods, they also have significant limitations: involvement of superficial corneal layers in the surgery, need for suturing, development of post-keratoplasty astigmatism etc. PURPOSE: This study aimed to test and describe the new method of closed sutureless keratoplasty (intracorneal selective stromal transplantation), which was indicated in isolated dystrophic and degenerative pathology of the stroma...
2024: Vestnik Oftalmologii
https://read.qxmd.com/read/38450465/-outcomes-of-hemi-descemet-membrane-endothelial-keratoplasty-and-phacoemulsification-for-the-treatment-of-primary-fuchs-endothelial-corneal-dystrophy-combined-with-cataract
#26
JOURNAL ARTICLE
B E Malyugin, A M Geliastanov, O P Antonova, E A Andreeva, M V Poletaeva, R S Isabekov
PURPOSE: This study evaluates the long-term results of surgical treatment of patients with Fuchs' endothelial corneal dystrophy and cataract. MATERIAL AND METHODS: The study included 24 patients (24 eyes) with primary Fuchs' endothelial corneal dystrophy and cataract, who underwent cataract phacoemulsification with IOL implantation and of Descemet's membrane endothelial keratoplasty with a semicircular graft (hemi-DMEK). The effect of treatment was assessed by best corrected visual acuity (BCVA), central corneal thickness (CCT) and endothelial cell density (ECD)...
2024: Vestnik Oftalmologii
https://read.qxmd.com/read/38448965/uv-light-mediated-corneal-crosslinking-as-lymph-angioregressive-pretreatment-to-promote-graft-survival-after-subsequent-high-risk-corneal-transplantation-crosscornealvision-protocol-for-a-multicenter-randomized-controlled-trial
#27
JOURNAL ARTICLE
Johanna Wiedemann, Deniz Hos, Endrik Limburg, Ulrike Zettelmeyer, Petra Schiller, Jeremy Franklin, Björn Bachmann, Daniel Böhringer, Tina Dietrich-Ntoukas, Thomas A Fuchsluger, Gerd Geerling, Stefan J Lang, Wolfgang Johann Mayer, Siegfried Priglinger, Thomas Reinhard, Berthold Seitz, Claus Cursiefen
BACKGROUND: Good vision highly depends on the transparency of the cornea, which is the "windscreen" of the eye. In fact, corneal blindness due to transparency loss is the second most common cause of blindness worldwide, and corneal transplantation is the main cure. Importantly, the cornea is normally avascular but can secondarily be invaded by pathological (blood and lymphatic) vessels due to severe inflammation, and the survival prognosis of a corneal graft mainly depends on the preoperative vascular condition of the recipient's cornea...
March 6, 2024: Trials
https://read.qxmd.com/read/38446253/use-of-discarded-corneo-scleral-rims-to-create-cornea-like-tissue
#28
JOURNAL ARTICLE
Maryada Sharma, Subhpreet Kaur, Nimisha A Mavlankar, Alokananda Chanda, Parul Chawla Gupta, Uma Nahar Saikia, Jagat Ram, Asish Pal, Sanjay Mandal, Purnananda Guptasarma, Manni Luthra-Guptasarma
BACKGROUND: Corneal disease is a major cause of blindness. Transplantation of cadaver-derived corneas (keratoplasty) is still the current therapy of choice; however, the global shortage of donor corneas continues to drive a search for alternatives. To this end, biosynthetic corneal substitutes have recently begun to gain importance. Here, we present a novel method for the generation of a cornea-like tissue (CLT), using corneo-scleral rims discarded after keratoplasty. METHODS AND RESULTS: Type I collagen was polymerized within the corneo-scleral rim, which functioned as a 'host' mould, directing the 'guest' collagen to polymerize into disc-shaped cornea-like material (CLM), displaying the shape, curvature, thickness, and transparency of normal cornea...
March 6, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38438857/comparison-of-therapeutic-effects-between-big-bubble-deep-anterior-lamellar-keratoplasty-and-penetrating-keratoplasty-for-medically-unresponsive-acanthamoeba-keratitis
#29
JOURNAL ARTICLE
Xiaolin Qi, Huilin Mao, Jinhui Liu, Yanling Dong, Man Du, Ting Liu, Ting Zhang, Xiuhai Lu, Hua Gao
PURPOSE: To compare the outcomes of big-bubble deep anterior lamellar keratoplasty (BB-DALK) and penetrating keratoplasty (PKP) in the management of medically unresponsive Acanthamoeba keratitis (AK). METHODS: This retrospective study included 27 eyes of BB-DALK and 24 eyes of PKP from a tertiary ophthalmology care centre. Glucocorticoid eye drops were subsequently added to the treatment plan 2 months postoperatively based on the evaluation using confocal laser scanning microscopy...
March 4, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38434572/fabrication-of-bioengineered-corneal-endothelial-grafts-using-an-allogeneic-cornea-derived-matrix
#30
REVIEW
Lijie Xie, Xiaojuan Dong, Jianping Ji, Chen Ouyang, Jing Wu, Chao Hou, Ting Huang
Corneal endothelial keratoplasty has been the primary treatment method of endothelial decompensation, but it is often limited in clinical practice due to global shortage of donor cornea. Here, we explored using an ultra-thin allogeneic cornea-derived matrix (uACM) films as a substrate for constructing bioengineered corneal endothelial grafts. We evaluated the films' optical, mechanical, and structural properties, and measured the composition of the extracellular matrix. The uACM was an ultrathin and curved cornea-shaped film with favorable optical and mechanical properties...
April 2024: Materials today. Bio
https://read.qxmd.com/read/38428773/3d-bioprinted-photo-crosslinkable-gelma-methylcellulose-hydrogel-mimicking-native-corneal-model-with-enhanced-in-vitro-cytocompatibility-and-sustained-keratocyte-phenotype-for-stromal-regeneration
#31
JOURNAL ARTICLE
Renuka Vijayaraghavan, Sravanthi Loganathan, Ravi Babu Valapa
Corneal transplantation serves as the standard clinical therapy for serious corneal disorders. However, rejection of grafts, significant expenditures, and most crucially, the global donor shortage, may affect the outcome. Recently, 3D bioprinting using biodegradable polymeric materials has become a suitable method for creating tissue replicas with identical architecture. One such most renowned material is GelMA, for its scaffold's three-dimensional structure, biocompatibility, robust mechanics, and favourable optical transmittance...
February 28, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38424221/clinical-outcomes-of-traumatic-globe-rupture-in-corneal-graft-patients
#32
JOURNAL ARTICLE
Francisco Figueiredo, Jas Sandhu, Michael Shaw
PURPOSE: This study reports the mechanisms, complications and graft survival following sight-threatening traumatic globe rupture in patients having previously undergone corneal transplantation in the same eye. METHODS: A retrospective, observational, single-center consecutive cohort study at the Royal Victoria Infirmary, Newcastle upon Tyne, UK over a 20-year period. Medical records and Newcastle Corneal Transplantation Service electronic database (eNCTS) review was undertaken of all consecutive patients who underwent corneal transplantation with a history of traumatic globe rupture...
February 29, 2024: International Ophthalmology
https://read.qxmd.com/read/38422520/patterned-collagen-films-loaded-with-mir-133b-mbg-nh2-for-potential-applications-in-corneal-stromal-injury-repair
#33
JOURNAL ARTICLE
Guancheng Zhan, Lixia Yu, Qiqi Wang, Longyang Jin, Xiaohong Yin, Xiaodong Cao, Huichang Gao
Corneal stromal injury is a common surgical disease. With the development of tissue engineering materials, many artificial corneal scaffolds have developed to replace allograft corneal transplantation and solve the problem of corneal donor shortage. However, few researchers have paid attention to corneal stromal wound healing. Herein, a nanocomposite of amino modified mesoporous bioactive glass (MBG-NH2) and microRNA-133b (miR-133b) was introduced into the patterned collagen films to achieve corneal stromal injury repair...
February 29, 2024: Biomedical Materials
https://read.qxmd.com/read/38421931/clinical-outcomes-and-indications-of-in-office-sutureless-dried-gamma-ray-sterilized-human-amniotic-membrane-transplantation-with-bandage-contact-lenses-in-various-ocular-surface-disorders
#34
JOURNAL ARTICLE
Kyu Seong Jo, Kook Young Kim, Yong Woo Lee, Sang Beom Han, Chul Young Choi
PURPOSE: The purpose of this study was to investigate the efficacy and indications of using dried gamma ray-sterilized amniotic membrane (AM) transplantation with bandage contact lenses for the in-office sutureless treatment of various ocular surface diseases. METHODS: This study retrospectively included 56 eyes of 52 patients with various ocular surface diseases treated with sutureless dehydrated AM-assisted therapeutic contact lenses. The patients were followed up and assessed 1, 2, and 4 weeks after the treatment, and the therapeutic contact lenses were removed after 1 or 2 weeks...
February 29, 2024: Cornea
https://read.qxmd.com/read/38417569/risk-of-corneal-graft-rejection-and-vaccination-a-matched-case-control-study-from-a-united-states-integrated-health-care-system
#35
JOURNAL ARTICLE
Jennifer H Ku, Afshan A Nanji, Julia E Tubert, Cynthia Joe, Divya Srikumaran, Kevin L Winthrop, Amanda E Brunton, Ana Florea, Frederick Fraunfelder, Tsaiyu Tseng, Yi Luo
PURPOSE: Data on vaccine-associated corneal transplant rejections are limited. We examined the association between graft rejection and vaccination. DESIGN: Matched case-control METHODS: We used electronic health records to identify corneal transplant recipients between 01/2008 and 08/2022 at Kaiser Permanente Southern California. Cases were transplant recipients who experienced a graft rejection (outcome) during the study period. Randomly selected controls who did not experience a corneal graft rejection at their matched cases' index date (rejection date) were matched in a 3:1 ratio to cases...
February 26, 2024: American Journal of Ophthalmology
https://read.qxmd.com/read/38415172/corneal-amyloid-staining-after-trypan-blue-in-descemet-s-membrane-endothelial-keratoplasty
#36
Alexandra Klejn, Robin G Abell
PURPOSE: This case report seeks to highlight impressive photographs of amyloid staining with trypan blue that persisted after DMEK surgery with 3 years follow-up. This has only been reported in the literature twice previously, and may have contributed to visual symptoms in the early post-operative period of this patient. OBSERVATIONS: We report a case of an 82-year-old patient with concurrent Fuchs' corneal endothelial dystrophy and lattice corneal dystrophy who suffered permanent trypan blue staining of the amyloid deposits after descemet's membrane endothelial keratoplasty (DMEK) surgery...
June 2024: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/38409732/serum-extracellular-vesicle-protein-profiling-for-prediction-of-corneal-transplant-rejection
#37
JOURNAL ARTICLE
Hyun Ju Lee, Eun-Hye Bae, Jong Min Choi, Hyemee Kim, Hyeon Ji Kim, Heather Barreda, Sung Yun Jung, Joo Youn Oh, Ryang Hwa Lee
BACKGROUND: Corneal transplantation is the most common transplant procedure worldwide. Despite immune and angiogenic privilege of the cornea, 50% to 70% of corneal transplants fail in high-risk recipients, primarily because of immune rejection. Therefore, it is crucial to identify predictive biomarkers of rejection to improve transplant survival. METHODS: In search for predictive biomarkers, we performed proteomics analysis of serum extracellular vesicles (EVs) in a fully major histocompatibility complex-mismatched (C57BL/6-to-BALB/c) murine corneal transplantation model, wherein 50% of transplants undergo rejection by day 28 following transplantation...
February 27, 2024: Transplantation
https://read.qxmd.com/read/38400535/herpes-simplex-keratitis-as-a-complication-of-pterygium-surgery
#38
REVIEW
Xinhan Cui, Jini Qiu, Feifei Huang, Chaoran Zhang, Tingting Shao, Yan Wang
BACKGROUND Infectious keratitis after pterygium surgery is a rare but potentially devastating complication. The present study presents 5 cases of herpes simplex keratitis (HSK) after pterygium surgery. CASE REPORT This study was conducted in our clinic in a 5-year period from February 2017 to September 2021. The 5 patients were men, aged between 42 and 73 years, with no prior history of herpes simplex virus (HSV) infections. Symptoms appeared near 1 month (median 30 days, range 10 to 70 days) after primary pterygium surgery...
February 24, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38399826/hybrid-aligned-fibers-of-electrospun-gelatin-with-antibiotic-and-polycaprolactone-composite-membranes-as-an-in-vitro-drug-delivery-system-to-assess-the-potential-repair-capacity-of-damaged-cornea
#39
JOURNAL ARTICLE
Yi-Hsin Shao, Ssu-Meng Huang, Shih-Ming Liu, Jian-Chih Chen, Wen-Cheng Chen
The cornea lacks the ability to repair itself and must rely on transplantation to repair damaged tissue. Therefore, creating alternative therapies using dressing membranes based on tissue engineering concepts to repair corneal damage before failure has become a major research goal. Themost outstanding features that are important in reconstructing a damaged cornea are the mechanical strength and transparency of the membrane, which are the most important standard considerations. In addition, preventing infection is an important issue, especially in corneal endothelial healing processes...
February 6, 2024: Polymers
https://read.qxmd.com/read/38389253/safety-and-efficacy-of-mccarey-kaufman-medium-supplemented-with-colistin-polymyxin-e-and-amphotericin-b-in-inhibiting-the-multidrug-resistant-pseudomonas-aeruginosa-using-an-ex-vivo-donor-corneal-infection-model
#40
JOURNAL ARTICLE
Kukutam Sushmasri, Priyasha Mishra, Sanhita Roy, Joveeta Joseph, Charanya Ramachandran, Kandibanda Srinivas, Sunita Chaurasia
PURPOSE: This study aimed to evaluate the efficacy and safety of McCarey-Kaufman (MK) medium supplemented with colistin and amphotericin B in inhibiting the growth of multidrug-resistant Pseudomonas (P.) aeruginosa , using an ex vivo experimental model with human donor corneas. METHODS: Cadaveric human corneas deemed unsuitable for corneal transplantation were obtained, and MK media were supplemented with colistin and amphotericin B. Multidrug-resistant P. aeruginosa was cultured and used to infect the human donor corneas ex vivo ...
February 23, 2024: Indian Journal of Ophthalmology
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