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Corneal Transplantation

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https://www.readbyqxmd.com/read/29343529/quarter-descemet-membrane-endothelial-keratoplasty-quarter-dmek-for-fuchs-endothelial-corneal-dystrophy-6-months-clinical-outcome
#1
Vasiliki Zygoura, Lamis Baydoun, Lisanne Ham, Vincent J A Bourgonje, Korine van Dijk, Jessica T Lie, Isabel Dapena, Silke Oellerich, Gerrit R J Melles
BACKGROUND/AIM: To assess the clinical outcome of the first series of Quarter-Descemet membrane endothelial keratoplasty (Quarter-DMEK), a potential hybrid technique between 'descemetorhexis only' and conventional, circular DMEK. METHODS: Prospective interventional case series at a tertiary referral centre. Twelve eyes of 12 patients with central Fuchs endothelial corneal dystrophy underwent Quarter-DMEK, that is, transplantation of one quadrant of a full-diameter DMEK graft, and were evaluated for best-corrected visual acuity (BCVA), endothelial cell density (ECD) and complications up to 6 months postoperatively...
January 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29339089/concentration-gradient-of-noradrenaline-from-the-periphery-to-the-centre-of-the-cornea-a-clue-to-its-origin
#2
Luis Figueira, Carla Ferreira, Catarina Janeiro, Paula Serrao, Fernando Falcao-Reis, Daniel Moura
We set out to demonstrate that the major source of corneal catecholamines is its neuronal release from intrinsic sympathetic nerves rather than circulating or non-neuronal local production. Three concentric segments (central, intermediate, peripheral) were obtained by double trephination (9.5-7.25 mm) performed on corneas harvested from 3-4 month old rabbits and human corneas rejected for transplantation, along with aqueous humour, full iris tissue and blood samples. Endogenous catecholamines were quantified by high pressure liquid chromatography with electrochemical detection (HPLC-ED), and comparison with the uptake of radio-labelled noradrenaline (3H-NA) before and after incubation with cocaine was performed...
January 12, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29335104/vision-related-quality-of-life-and-dependency-in-french-keratoconus-patients-impact-study
#3
Valentine Saunier, Audrey-Elodie Mercier, Thibaut Gaboriau, Florence Malet, Joseph Colin, Pierre Fournié, François Malecaze, David Touboul
PURPOSE: To assess the quality of life in French keratoconus patients. SETTING: Fifty-seven Keratoconus National Reference Centers across France. DESIGN: Prospective case series. METHODS: Patients completed the National Eye Institute Visual Functioning Questionnaire-25 (NEI VFQ-25) and a French validated questionnaire on disability and dependency from February to June 2012 when they came for an ophthalmic examination at 57 participating centers across France...
December 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29332157/acanthamoeba-keratitis-in-porto-alegre-southern-brazil-28-cases-and-risk-factors
#4
Denise Leal Dos Santos, Sergio Kwitko, Diane Ruschel Marinho, Bruno Schneider de Araújo, Claudete Inês Locatelli, Marilise Brittes Rott
The increasing use of contact lenses worldwide has led to an increase in cases of Acanthamoeba keratitis, which are often associated with inappropriate cleaning of contact lenses and lens cases. This study aimed to retrospectively review 28 cases of Acanthamoeba keratitis in Porto Alegre (southern Brazil) and identify the risk factors and clinical outcomes of affected patients. Most patients had higher education (66.6%), all were users of contact lenses, mostly women (67.9%). Most patients were soft contact lens wearers (66...
January 14, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29332131/assessment-of-human-corneas-prior-to-transplantation-using-high-resolution-two-photon-imaging
#5
Ana Batista, Hans Georg Breunig, Aisada König, Andreas Schindele, Tobias Hager, Berthold Seitz, António Miguel Morgado, Karsten König
Purpose: The purpose of this study was to evaluate the feasibility of using two-photon imaging (TPI) to assess the condition of human corneas for transplantation. Methods: Human corneas were imaged after different storage times: short-term (STS), medium-term (MTS), and long-term (LTS) storage. A high-resolution, custom-built 5-dimensional multiphoton microscope with 12-fs pulsed laser excitation was used for image acquisition. Results: Optical discrimination between different corneal layers and sublayers based on their morphologic characteristics revealed by two-photon autofluorescence (AF) is possible...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29325021/oligonucleotides-targeting-tcf4-triplet-repeat-expansion-inhibit-rna-foci-and-mis-splicing-in-fuchs-dystrophy
#6
Jiaxin Hu, Ziye Rong, Xin Gong, Zhengyang Zhou, Vivek K Sharma, Chao Xing, Jonathan K Watts, David R Corey, V Vinod Mootha
Fuchs' endothelial corneal dystrophy (FECD) is the most common repeat expansion disorder. FECD impacts 4% of United States population and is the leading indication for corneal transplantation. Most cases are caused by an expanded intronic CUG tract in the TCF4 gene that forms nuclear foci, sequesters splicing factors, and impairs splicing. We investigated the sense and antisense RNA landscape at the FECD gene and find that the sense expanded repeat transcript is the predominant species in patient corneas. In patient tissue, sense foci number were negatively correlated with age and showed no correlation with sex...
January 8, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29307015/therapeutic-approaches-for-induction-of-tolerance-and-immune-quiescence-in-corneal-allotransplantation
#7
REVIEW
Maryam Tahvildari, Afsaneh Amouzegar, William Foulsham, Reza Dana
The cornea is the most commonly transplanted tissue in the body. Corneal grafts in low-risk recipients enjoy high success rates, yet over 50% of high-risk grafts (with inflamed and vascularized host beds) are rejected. As our understanding of the cellular and molecular pathways that mediate rejection has deepened, a number of novel therapeutic strategies have been unveiled. This manuscript reviews therapeutic approaches to promote corneal transplant survival through targeting (1) corneal lymphangiogenesis and hemangiogenesis, (2) antigen presenting cells, (3) effector and regulatory T cells, and (4) mesenchymal stem cells...
January 6, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29296553/effect-of-air-lifting-on-the-stemness-junctional-protein-formation-and-cytokeratin-expression-of-in-vitro-cultivated-limbal-epithelial-cell-sheets
#8
Lily Wei Chen, Yan-Ming Chen, Chia-Ju Lu, Mei-Yun Chen, Szu-Yuan Lin, Fung-Rong Hu, Wei-Li Chen
PURPOSE: The aim of this study is to evaluate the effects of air-lifting on the stemness, junctional protein formation, and cytokeratin expression of rabbit limbal stem cells cultivated in vitro, and to find out the proper timing of air-lifting before transplantation as limbal epithelial cell sheets for the treatment of limbal insufficiency. MATERIALS AND METHODS: Limbal epithelial cells were isolated from the limbus of New Zealand white rabbits and cultivated in vitro...
October 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29296489/deformation-velocity-imaging-using-optical-coherence-tomography-and-its-applications-to-the-cornea
#9
Samuel Lawman, Peter W Madden, Vito Romano, Yue Dong, Sharon Mason, Bryan M Williams, Stephen B Kaye, Colin E Willoughby, Simon P Harding, Yao-Chun Shen, Yalin Zheng
Optical coherence tomography (OCT) can monitor human donor corneas non-invasively during the de-swelling process following storage for corneal transplantation, but currently only resultant thickness as a function of time is extracted. To visualize and quantify the mechanism of de-swelling, we present a method exploiting the nanometer sensitivity of the Fourier phase in OCT data to image deformation velocities. The technique was demonstrated by non-invasively showing during de-swelling that osmotic flow through an intact epithelium is negligible and removing the endothelium approximately doubled the initial flow at that interface...
December 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29287709/angiogenesis-and-lymphangiogenesis-in-corneal-transplantation-a-review
#10
REVIEW
Wei Zhong, Mario Montana, Samuel M Santosa, Irene D Isjwara, Yu-Hui Huang, Kyu-Yeon Han, Christopher O'Neil, Ashley Wang, Maria Soledad Cortina, Jose de la Cruz, Qiang Zhou, Mark Rosenblatt, Jin-Hong Chang, Dimitri T Azar
Corneal transplantation has been proven effective for returning the gift of sight to those affected by corneal disorders such as opacity, injury, and infections that are a leading cause of blindness. Immune privilege plays an important role in the success of corneal transplantation procedures; however, immune rejection reactions do occur, and they, in conjunction with a shortage of corneal donor tissue, continue to pose major challenges. Corneal immune privilege is important to the success of corneal transplantation and closely related to the avascular nature of the cornea...
December 26, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29283122/results-of-simple-limbal-epithelial-transplantation-in-unilateral-ocular-surface-burn
#11
Nidhi Gupta, Jagdish Joshi, Javed Hussain Farooqui, Umang Mathur
PURPOSE: This study aimed to report the long-term outcomes of autologous Simple Limbal Epithelial Transplantation (SLET) performed for unilateral limbal stem cell deficiency (LSCD) following chemical burn at a tertiary eye center in North India. METHODS: This was a single-center prospective interventional case series of patients who developed unilateral LSCD after suffering from ocular surface burns and who underwent SLET between October 2012 and May 2016 with a follow-up period of at least 6 months...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29281419/electro-spun-membranes-as-scaffolds-for-human-corneal-endothelial-cells
#12
Magnus Kruse, Peter Walter, Benedict Bauer, Stephan Rütten, Karola Schaefer, Niklas Plange, Thomas Gries, Stefan Jockenhoevel, Matthias Fuest
BACKGROUND: Corneal endothelial dysfunction remains the most frequent indication for corneal transplantation, limited by donor material shortage, poor long-term graft survival, or allogeneic graft rejection. Therefore, tissue-engineered endothelial grafts (TEEG) represent a promising alternative to human donor tissue. In this study, we generated electro-spun scaffolds and tested these for their suitability for human corneal endothelial cell (hCEC) cultivation. METHODS: The polymers poly(methyl-methacrylate) (PMMA), poly(lactic-co-glycolic acid) (PLGA), and polycaprolactone (PCL) were spun with equal parameters...
January 2018: Current Eye Research
https://www.readbyqxmd.com/read/29279602/new-therapeutic-perceptions-in-a-patient-with-complicated-herpes-simplex-virus-1-keratitis-a-case-report-and-review-of-the-literature
#13
REVIEW
Dimitrios Kalogeropoulos, Aliki Geka, Konstantinos Malamos, Maria Kanari, Chris Kalogeropoulos
BACKGROUND Keratitis caused by herpes simplex virus (HSV) can have detrimental effects on the cornea leading to loss of vision. Modern therapies can contribute to the prevention of anatomical and functional damage. CASE REPORT An 80-year-old male with complicated HSV-1 keratitis of the left eye (confirmed diagnosis after microbiological investigation) presented three months after antiviral treatment with corneal blurring, severe epitheliopathy, thinning of the stroma, and neovascularization. At the time he was referred, the visual acuity of his left eye was very low, as he could only count fingers at a one-foot distance...
December 27, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29260063/results-with-the-boston-type-i-keratoprosthesis-after-acanthamoeba-keratitis
#14
Albert Santos, Luzia Diegues Silva, Luciene Barbosa de Sousa, Denise de Freitas, Lauro Augusto de Oliveira
Purpose: To report the outcomes of implantation of the Boston Type I keratoprosthesis in three patients with Acanthamoeba keratitis (AK), a severe infection that can lead to significant visual loss. Observations: Case series reporting three patients with difficult cases of AK that needed multiple corneal transplantations and glaucoma surgeries. All patients were implanted with the Boston Type I keratoprosthesis device. The main outcomes measure were the visual function and anatomical retention after implantation of the Boston Type I keratoprosthesis...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29260042/conjunctival-squamous-papilloma-refractory-to-interferon-%C3%AE-2b-in-a-patient-on-systemic-immunosuppression-tacrolimus
#15
Preethi S Ganapathy, Thomas Plesec, Arun D Singh
Purpose: To describe a case of diffuse conjunctival papilloma in an immunocompromised individual on tacrolimus that was refractory to treatment with interferon α-2b, but responded to topical mitomycin-c. Observations: A 79-year-old Caucasian female with a history of a liver transplant twenty years ago, who was immunosuppressed with tacrolimus (2 mg daily) presented with a diffuse conjunctival and corneal squamous papilloma. Following treatment with four weekly subconjunctival interferon-α2b injections (3 million units/0...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29259248/aav-vector-meditated-expression-of-hla-g-reduces-injury-induced-corneal-vascularization-immune-cell-infiltration-and-fibrosis
#16
Matthew L Hirsch, Laura M Conatser, Sara M Smith, Jacklyn H Salmon, Jerry Wu, Nicholas E Buglak, Rich Davis, Brian C Gilger
Over 1.5 million individuals suffer from cornea vascularization due to genetic and/or environmental factors, compromising visual acuity and often resulting in blindness. Current treatments of corneal vascularization are limited in efficacy and elicit undesirable effects including, ironically, vision loss. To develop a safe and effective therapy for corneal vascularization, adeno-associated virus (AAV) gene therapy, exploiting a natural immune tolerance mechanism induced by human leukocyte antigen G (HLA-G), was investigated...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29245335/spontaneous-corneal-perforation-in-terrien-s-marginal-degeneration-in-childhood-a-case-report
#17
Junkyu Chung, Kyung Hyun Jin, Jaheon Kang, Tae Gi Kim
RATIONALE: Terrien's marginal corneal degeneration (TMD) is characterized by progressive peripheral corneal thinning. It appears primarily above the age of 40 years and is rare at younger ages. Spontaneous corneal perforation in TMD is a rare, but serious complication that may occur in childhood. PATIENT CONCERNS: This review presents the case of a 16-year-old girl presented with blurred vision in the right eye on awakening in the morning. Slit-lamp examination revealed superior corneal thinning with a corneal perforation...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29242495/the-evolution-of-corneal-transplantation
#18
Tobias Röck, Johanna Landenberger, Matthias Bramkamp, Karl Ulrich Bartz-Schmidt, Daniel Röck
BACKGROUND The aim of this study was to investigate the evolution of surgical methods in and leading indications for corneal transplantation from 2005 to 2016. MATERIAL AND METHODS Data from the corneal graft waiting list and from all keratoplasties carried out between 2005 and 2016 at the University Eye Hospital Tübingen were retrospectively evaluated. RESULTS A total of 1259 keratoplasties were performed between 2005 and 2016 at the University Eye Hospital Tübingen. The most common surgical indications for corneal transplantation were Fuchs endothelial corneal dystrophy (45...
December 15, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29240299/the-effect-of-haemopoietic-stem-cell-transplantation-on-the-ocular-phenotype-in-mucopolysaccharidosis-type-i-hurler
#19
Ahmed Javed, Tariq Aslam, Simon A Jones, Jean Mercer, Karen Tyler, Heather Church, Arunabha Ghosh, Robert Wynn, Krishanthy Sornalingam, Jane Ashworth
PURPOSE: To determine whether the ocular phenotype in patients with mucopolysaccharidosis type I (MPSI) Hurler is affected by the efficacy of previous haemopoietic stem cell transplantation (HSCT). DESIGN: A retrospective cohort study of patients with MPSI who had undergone treatment with HSCT. METHODS: Ocular phenotype was documented for each patient and compared to levels of biomarkers representing efficacy of previous transplantation. MAIN OUTCOME MEASURES: Assessment of visual acuity (VA), severity of corneal clouding and the presence of optic neuropathy or retinopathy...
December 14, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29239730/directed-differentiation-of-periocular-mesenchyme-from-human-embryonic-stem-cells
#20
Matthew Lovatt, Gary Hin-Fai Yam, Gary S Peh, Alan Colman, N Ray Dunn, Jodhbir S Mehta
Corneal tissue is the most transplanted of all body tissues. Currently, cadaveric donor tissues are used for transplantation. However, a global shortage of transplant grade material has prompted development of alternative, cell-based therapies for corneal diseases. Pluripotent stem cells are attractive sources of cells for regenerative medicine, because large numbers of therapeutically useful cells can be generated. However, a detailed understanding of how to differentiate clinically relevant cell types from stem cells is fundamentally required...
November 16, 2017: Differentiation; Research in Biological Diversity
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