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Corneal Transplantation

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https://www.readbyqxmd.com/read/29149984/corneal-xenotransplantation-from-pig-to-rhesus-monkey-no-signs-of-transmission-of-endogenous-porcine-retroviruses
#1
A Li, Y Zhang, Y Liu, Z Pan
BACKGROUND: Xenotransplantations of pig corneas have become an attractive alternative to human corneas. Such xenotransplantations carry the danger, however, of transmission of porcine endogenous retroviruses (PERVs). Here, we investigated whether porcine corneas harbor viral DNA and RNA and whether transplantation to a nonhuman primate would lead to host PERV infection. METHODS: Monkey vein endothelial cells (MVECs) were inoculated with porcine aortic endothelial cell (PAEC) supernatants, and DNA and total RNA of MVECs were tested for PERV by polymerase chain reaction (PCR) and reverse transcription PCR (RT-PCR) assays...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149876/impact-of-donor-graft-quality-on-deep-anterior-lamellar-keratoplasty-dalk
#2
Friederike Schaub, Philip Enders, Werner Adler, Björn O Bachmann, Claus Cursiefen, Ludwig M Heindl
BACKGROUND: To evaluate main features of donor tissue that may influence clinical outcome or complication rate after deep anterior lamellar keratoplasty (DALK). METHODS: Donor tissue parameters of 84 consecutive corneal donor grafts used for big-bubble DALK surgery between June 2011 and December 2014 in 84 eyes of 84 patients with disorders of anterior corneal stroma were correlated to clinical outcome parameters of recipient eyes 12 months after surgery and 3 months after total suture removal...
November 17, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29149239/label-free-in-vivo-imaging-of-corneal-lymphatic-vessels-using-microscopic-optical-coherence-tomography
#3
Jens Horstmann, Hinnerk Schulz-Hildebrandt, Felix Bock, Sebastian Siebelmann, Eva Lankenau, Gereon Hüttmann, Philipp Steven, Claus Cursiefen
Purpose: Corneal neovascularization, in particular lymphangiogenesis, is a limiting factor in corneal transplant survival. Novel treatment approaches focus on (selective) inhibition and regression of lymphatic vessels. Imaging clinically invisible corneal lymphatic vessels is a prerequisite for these strategies. Using a murine model, this study investigates whether corneal lymphatic vessels can be imaged using microscopic optical coherence tomography (mOCT). Methods: Corneal neovascularization was induced by intrastromal placement of 11...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29146208/glaucoma-associated-corneal-endothelial-cell-damage-a-review
#4
REVIEW
Ben J Janson, Wallace L Alward, Young H Kwon, Daniel I Bettis, John H Fingert, Lorraine M Provencher, Kenneth M Goins, Michael D Wagoner, Mark A Greiner
The corneal endothelium is critical in maintaining a healthy and clear cornea. Corneal endothelial cells have a significant reserve function, but preservation of these cells is paramount as they have limited regenerative capacity. Glaucoma is a prevalent disease, and damage to the corneal endothelium may be caused by the disease process itself as well as by its treatment. The mechanisms involved in glaucoma-associated damage to the corneal endothelium need further investigation. Understanding how glaucoma and glaucoma surgery impact the endothelium is important for protecting corneal clarity and visual acuity in all glaucoma patients, including those undergoing corneal transplant...
November 13, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29145577/photodynamic-therapy-leads-to-time-dependent-regression-of-pathologic-corneal-lymph-angiogenesis-and-promotes-high-risk-corneal-allograft-survival
#5
Yanhong Hou, Viet Nhat Hung Le, Thomas Clahsen, Ann-Charlott Schneider, Felix Bock, Claus Cursiefen
Purpose: Pathologic corneal (lymph) angiogenesis is a known risk factor for immune-mediated allograft rejections after corneal transplantation. However, there is no established treatment to regress pre-existing pathological corneal blood and lymphatic vessels. This study assessed the possibility to regress both vessel types by photodynamic therapy (PDT) after intravenous (i.v.) verteporfin injection, the influence of timing of PDT after verteporfin injection, and the effect on graft survival in high-risk keratoplasty...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29140823/single-center-retrospective-study-on-meibomian-gland-loss-in-patients-with-ocular-chronic-graft-versus-host-disease
#6
Lijuan Que, Xiaofeng Zhang, Mengmeng Li
OBJECTIVES: This study aimed to analyze the influencing factors of meibomian gland loss in patients with ocular chronic graft-versus-host disease (GVHD) and its correlation with other clinical ocular surface assessment indexes. METHODS: The clinical data of patients with ocular chronic GVHD from the ocular surface and corneal outpatient clinic of the First Affiliated Hospital of Soochow University were reviewed from June 2012 to June 2016. The relationship between the percentage of meibomian gland acinar area and the influencing factors, such as patient's sex, age, transplantation method, human leukocyte antigen (HLA) matching, the time when eye discomfort appeared after transplantation (month), and the severity of ocular chronic GVHD, was investigated...
November 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29139373/primary-malignant-melanoma-of-the-bladder
#7
Maurizio Buscarini, Claudio Conforti, Raffaele Antonelli Incalzi, Cristina Falavolti, Chiara Taffon, Giovanni Muto, Caterina Dianzani
A 81-year-old man was admitted to our university for a second opinion after diagnosis of bladder melanoma in December 2014. His medical history included arterial hypertension, hypothyroidism, peripheral arterial disease treated with a bypass, and corneal transplantation. His medical history was negative for malignant melanoma. He experienced gross hematuria in the absence of any other clinical manifestations, and urine cytology identified atypical cells. The patient underwent transurethral resection of the bladder with diagnosis of melanoma...
2017: Skinmed
https://www.readbyqxmd.com/read/29133638/comparison-of-the-endosaver-with-noninjector-techniques-in-descemet-s-stripping-endothelial-keratoplasty
#8
Michael Tsatsos, Ioannis Athanasiadis, Nikolaos Kopsachilis, Radhika Krishnan, Parwez Hossain, David Anderson
PURPOSE: Minimal loss of corneal endothelial cells during corneal transplantation is a major target but remains a point of controversy among specialists. Hence, the available method to best achieve this continues to stir progress in the field. The aim of this study is to evaluate the use of the Endosaver injector device for graft insertion in Descemet's stripping endothelial keratoplasty (DSEK) and compare the visual outcomes and endothelial cell survival between the Endosaver injector and Goosey grasping forceps insertion techniques...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29122822/posterior-keratoconus
#9
REVIEW
Megan R Silas, Sarah M Hilkert, James J Reidy, Asim V Farooq
Posterior keratoconus (PKC) is a rare, typically non-inflammatory condition that is characterised by an abnormal posterior corneal curvature, which may be accompanied by overlying stromal opacification. It is usually congenital and can be associated with other ocular and systemic abnormalities. PKC remains a clinical diagnosis, although imaging techniques including ultrasound biomicroscopy and anterior segment optical coherence tomography may be useful tools for confirmation and classification. Genetic studies should be considered, although no specific genetic defects have been identified thus far...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29121878/comparison-of-femtosecond-laser-assisted-corneal-intrastromal-xenotransplantation-and-the-allotransplantation-in-rhesus-monkeys
#10
He Jin, Liangping Liu, Hui Ding, Miao He, Chi Zhang, Xingwu Zhong
BACKGROUND: In our previous study, we showed that both allogeneic and autogeneic small-incision femtosecond laser-assisted corneal intrastromal transplantation are safe and effective surgeries. However, the results of small-incision femtosecond laser-assisted intrastromal xenotransplantation have not yet been explored. Additionally, we suggest that glycerol-dehydrated corneal lamellae might provide a possible alternative for this xenogenic implantation approach. METHODS: Corneal inlay lamellae were produced from rabbits and humans using femtosecond laser-assisted surgeries and were dehydrated in glycerol for 1 week at 4 °C...
November 9, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29118495/emergency-visits-after-corneal-transplantation-in-yemen
#11
Mahfouth Abdalla Bamashmus, Saleh A Al-Akily, Hisham A AlAkhalee, Khaldoon O Al-Nuseriy, Marwan H Farhan
PURPOSE: Awareness of symptoms and signs of possible complications after corneal transplantation is very important. Early presentation can enhance long-term survival of the cornea. This study evaluates the reasons for emergency presentation and management of postcorneal transplantation complications. PATIENTS AND METHODS: This retrospective study included a total of 134 postkeratoplasty patients at the cornea unit in Yemen Magrabi Eye Hospital in Sana'a between 2008 and 2010...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29116027/poly-ethylene-glycol-modified-silk-fibroin-membrane-as-a-carrier-for-limbal-epithelial-stem-cell-transplantation-in-a-rabbit-lscd-model
#12
Yijian Li, Yuli Yang, Lei Yang, Yuxiao Zeng, Xiaowei Gao, Haiwei Xu
BACKGROUND: Limbal epithelial stem cells (LESCs) play important roles in corneal epithelial homeostasis and regeneration, and damage to the limbus will lead to limbal stem cell deficiency (LSCD), with conjunctivalization and even visual impairment. Cultured LESCs have been used for ocular surface reconstruction, and silk fibroin (SF) membranes have shown potential as a substrate for LESC cultivation. Both culture methods and the carriers of LESCs affect outcomes following LESC transplantation...
November 7, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29109898/limbal-stem-cell-deficiency-and-treatment-with-stem-cell-transplantation
#13
REVIEW
Özlem Barut Selver, Ayşe Yağcı, Sait Eğrilmez, Mehmet Gürdal, Melis Palamar, Türker Çavuşoğlu, Utku Ateş, Ali Veral, Çağrı Güven, Jose Mario Wolosin
The cornea is the outermost tissue of the eye and it must be transparent for the maintenance of good visual function. The superficial epithelium of the cornea, which is renewed continuously by corneal stem cells, plays a critical role in the permanence of this transparency. These stem cells are localized at the cornea-conjunctival transition zone, referred to as the limbus. When this zone is affected/destroyed, limbal stem cell deficiency ensues. Loss of limbal stem cell function allows colonization of the corneal surface by conjunctival epithelium...
October 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29107055/native-and-synthetic-scaffolds-for-limbal-epithelial-stem-cell-transplantation
#14
REVIEW
Kim N Nguyen, Samantha Bobba, Alexander Richardson, Mijeong Park, Stephanie L Watson, Denis Wakefield, Nick Di Girolamo
Limbal stem cell deficiency (LSCD) is a complex blinding disease of the cornea, which cannot be treated with conventional corneal transplants. Instead, a stem cell (SC) graft is required to replenish the limbal epithelial stem cell (LESC) reservoir, which is ultimately responsible for regenerating the corneal epithelium. Current therapies utilize limbal tissue biopsies that harbor LESCs as well as tissue culture expanded cells. Typically, this tissue is placed on a scaffold that supports the formation of corneal epithelial cell sheets, which are then transferred to diseased eyes...
November 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29105366/limbal-stem-cells-identity-developmental-origin-and-therapeutic-potential
#15
REVIEW
Gabriel Gonzalez, Yuzuru Sasamoto, Bruce R Ksander, Markus H Frank, Natasha Y Frank
The cornea is our window to the world and our vision is critically dependent on corneal clarity and integrity. Its epithelium represents one of the most rapidly regenerating mammalian tissues, undergoing full-turnover over the course of approximately 1-2 weeks. This robust and efficient regenerative capacity is dependent on the function of stem cells residing in the limbus, a structure marking the border between the cornea and the conjunctiva. Limbal stem cells (LSC) represent a quiescent cell population with proliferative capacity residing in the basal epithelial layer of the limbus within a cellular niche...
November 3, 2017: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/29104070/the-role-of-amniotic-membrane-extract-eye-drop-ameed-in-in-vivo-cultivation-of-limbal-stem-cells
#16
Alireza Baradaran-Rafii, Niloufar Shayan Asl, Marzieh Ebrahimi, Sayena Jabbehdari, Shahram Bamdad, Danial Roshandel, Medi Eslani, Maryam Momeni
BACKGROUND: Limbal stem cell transplantation (LSCT) is the definitive treatment for total limbal stem cell deficiency (LSCD). This study evaluates the anatomical and visual outcomes of a surgical technique supplemented by amniotic membrane extract eye drop (AMEED) for in vivo cultivation of limbal stem cells (LSCs). METHODS: One small limbal block (2 × 1 mm) harvested from the contralateral healthy eye was transferred to the diseased eye, which had been already covered by cryopreserved amniotic membrane (N = 20)...
November 2, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29103962/corneal-stroma-enhancement-with-decellularized-stromal-laminas-with-or-without-stem-cell-recellularization-for-advanced-keratoconus
#17
Jorge L Alió Del Barrio, Mona El Zarif, Albert Azaar, Nehman Makdissy, Charbel Khalil, Walid Harb, Ibrahim El Achkar, Ziad Abdul Jawad, María P de Miguel, Jorge L Alió
PURPOSE: Phase-1 study to preliminarily evaluate the safety and efficacy of decellularized human corneal stromal lamina transplantation with or without autologous adipose derived adult stem cells (ADASC) recellularization within the corneal stroma of patients with advanced keratoconus. DESIGN: Phase one clinical trial METHODS: Femtosecond-assisted 120μm-thickness and 9mm-diameter laminas were obtained from the anterior stroma of human donor corneas and decellularized with a sodium dodecyl sulfate solution...
November 2, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29103959/scleral-lenses-reduce-the-need-for-corneal-transplants-in-severe-keratoconus
#18
Carina Koppen, Elke O Kreps, Lieselotte Anthonissen, Maarten Van Hoey, Sorcha Ni Dhubhghaill, Louise Vermeulen
PURPOSE: To investigate the success and failure rates of scleral lens correction in severe keratoconus. DESIGN: Retrospective case series. METHODS: Study population: Patients with keratoconus who attended the keratoconus clinic at the Antwerp University Hospital, Belgium between 01/01/2010 and 12/31/2014. The included eyes had maximal keratometry values ≥ 70 D, as measured using the sagittal curvature map that was obtained by Scheimpflug tomography...
November 2, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29103099/thermal-imaging-of-corneal-transplant-rejection
#19
Matthew C Sniegowski, Michael Erlanger, Jeffery Olson
PURPOSE: Corneal transplant rejection is one of the most frequent complications, with a reported incidence of 16-30%. In our current research, we investigated the use of infrared thermography to detect ocular surface temperature. We also looked at a case of corneal transplant rejection and this case had an elevated ocular surface temperature when compared to the contralateral eye and other eyes without corneal transplant rejection. METHODS: Twenty-three eyes of twelve patients would serve as control to one eye with clinically evident corneal transplant graft rejection...
November 4, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29103026/effect-of-minocycline-on-vascular-proliferation-after-corneal-alkaline-burn-a-mechanism-study
#20
Haijun Wu, Xin Dai, Hui Li, Chunying Lv
Impairment of vision or blindness always occurs in the progress of corneal neovascularization (CNV). CNV may cause corneal graft rejection at corneal transplant status. Thus, intervention of CNV is of concern to clinical treatment. Given minocycline was reported with inhibiting effect on CNV, our study was focused on specific effect of minocycline on CNV after corneal alkaline burn. Seventy-five male Sprague Dawley rats were randomly assigned into three groups with an equal number (25). Sodium hydroxide (NaOH) solution was used to establish corneal alkaline burn model...
October 20, 2017: Cancer Biomarkers: Section A of Disease Markers
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