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https://www.readbyqxmd.com/read/29048177/the-role-of-a-palliative-care-intervention-in-moderating-the-relationship-between-depression-and-survival-among-individuals-with-advanced-cancer
#1
Anna T Prescott, Jay G Hull, J Nicholas Dionne-Odom, Tor D Tosteson, Kathleen Doyle Lyons, Zhigang Li, Zhongze Li, Konstantin H Dragnev, Mark T Hegel, Karen E Steinhauser, Tim A Ahles, Marie A Bakitas
OBJECTIVE: Randomized controlled trials (RCTs) of early palliative care interventions in advanced cancer have positively impacted patient survival, yet the mechanisms remain unknown. This secondary analysis of 2 RCTs assessed whether an early palliative care intervention moderates the relationship between depressive symptoms and survival. METHOD: The relationships among mood, survival, and early palliative care intervention were studied among 529 advanced cancer patients who participated in 2 RCTs...
October 19, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29047059/characterization-of-carbonaceous-fractions-in-pm2-5-and-pm10-over-a-typical-industrial-city-in-central-china
#2
Changlin Zhan, Jiaquan Zhang, Jingru Zheng, Ruizhen Yao, Ping Wang, Hongxia Liu, Wensheng Xiao, Xianli Liu, Junji Cao
Aerosol samples of PM2.5 and PM10 were collected every 6 days from March 2012 to February 2013 in Huangshi, a typical industrial city in central China, to investigate the characteristics, relationships, and sources of carbonaceous species. The PM2.5 and PM10 samples were analyzed for organic carbon (OC), elemental carbon (EC), char, and soot using the thermal/optical reflectance (TOR) method following the IMPROVE_A protocol. PM2.5 and PM10 concentrations ranged from 29.37 to 501.43 μg m(-3) and from 50...
October 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29046641/buspirone-counteracts-mk-801-induced-schizophrenia-like-phenotypes-through-dopamine-d3-receptor-blockade
#3
Sebastiano Alfio Torrisi, Salvatore Salomone, Federica Geraci, Filippo Caraci, Claudio Bucolo, Filippo Drago, Gian Marco Leggio
Background: Several efforts have been made to develop effective antipsychotic drugs. Currently, available antipsychotics are effective on positive symptoms, less on negative symptoms, but not on cognitive impairment, a clinically relevant dimension of schizophrenia. Drug repurposing offers great advantages over the long-lasting, risky and expensive, de novo drug discovery strategy. To our knowledge, the possible antipsychotic properties of buspirone, an azapirone anxiolytic drug marketed in 1986 as serotonin 5-HT1A receptor (5-HT1AR) partial agonist, have not been extensively investigated despite its intriguing pharmacodynamic profile, which includes dopamine D3 (D3R) and D4 receptor (D4R) antagonist activity...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29045932/modulation-of-sestrin-confers-protection-to-cr-vi-induced-neuronal-cell-death-in-drosophila-melanogaster
#4
Pallavi Singh, D Kar Chowdhuri
Increased oxidative stress is one of the major causes of hexavalent chromium [Cr(VI)], a heavy metal with diverse applications and environmental presence, induced neuronal adversities in exposed organism including Drosophila. Sestrin (sesn), an oxidative stress responsive gene, emerges as a novel player in the management of oxidative stress response. It is reported to be regulated by Target of rapamycin (TOR) and the former regulates autophagy and plays an important role in the prevention of neurodegeneration...
October 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29043790/emissive-synthetic-cofactors-an-isomorphic-isofunctional-and-re-sponsive-nad-analogue
#5
Alexander R Rovira, Andrea Fin, Yitzhak Tor
The synthesis, photophysics, and biochemical utility of a new fluorescent NAD(+) analogue based on an isothiazolo[4,3-d]pyrimidine core (N(tz)AD(+)) are described. Enzymatic reactions, photophysically monitored in real time, show N(tz)AD(+) and N(tz)ADH to be substrates for yeast alcohol dehydrogenase and lactate dehydrogenase, respectively, with reaction rates comparable to that of the native cofactors. As the emissive N(tz)AD(+) is converted to the corresponding N(tz)ADH, a drop in fluorescence occurs, displaying complementary photophysical behavior to that of the native NAD(+)/NADH...
October 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29043751/h%C3%A3-vard-viko
#6
Jan-Bjørn Osnes, Tor Skomedal, Oliver Meyerdierks, Solbjørg Sagedal, Harald Langberg, Branimir Draganov
No abstract text is available yet for this article.
October 16, 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29043734/nye-retningslinjer-for-forebygging-av-hjerte-og-karsykdom
#7
Tor Ole Klemsdal, Bjørn Gjelsvik, Inger Elling, Sirin Johansen, Sverre E Kjeldsen, Øivind Kristensen, Steinar Madsen, Inger Njølstad, Randi Selmer, Serena Tonstad, Hilde Voie
No abstract text is available yet for this article.
October 16, 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29043726/alle-m%C3%A3-kunne-gj%C3%A3-re-valg-om-egen-behandling
#8
Tor Levin Hofgaard
No abstract text is available yet for this article.
October 16, 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29040838/nutrient-sensing-and-metabolic-changes-after-methionine-deprivation-in-primary-muscle-cells-of-turbot-scophthalmus-maximus-l
#9
Haowen Jiang, Fuyun Bian, Huihui Zhou, Xuan Wang, Kaidi Wang, Kangsen Mai, Gen He
The low methionine content in plant-based diets is a major limiting factor for feed utilization by animals. However, the molecular consequences triggered by methionine deficiency have not been well characterized, especially in fish species, whose metabolism is unique in many aspects and important for aquaculture industry. In the present study, the primary muscle cells of turbot (Scophthalmus maximus L.) were isolated and treated with or without methionine for 12 h in culture. The responses of nutrient sensing pathways, the proteomic profiling of metabolic processes, and the expressions of key metabolic molecules were systematically examined...
September 14, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29040073/removal-of-model-viruses-e-coli-and-cryptosporidium-oocysts-from-surface-water-by-zirconium-and-chitosan-coagulants
#10
Ekaterina Christensen, Vegard Nilsen, Tor Håkonsen, Arve Heistad, Christophe Gantzer, Lucy J Robertson, Mette Myrmel
The present work evaluates the effect of contact filtration, preceded by coagulation with zirconium (Zr) and chitosan coagulants, on model microorganisms and waterborne pathogens. River water intended for potable water production was spiked with MS2 and Salmonella Typhimurium 28B bacteriophages, Escherichia coli, and Cryptosporidium parvum oocysts prior to coagulation. The hygienic performance demonstrated by Zr comprised 3.0-4.0 log10 removal of viruses and 5.0-6.0 log10 removal of E. coli and C. parvum oocysts...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29039249/visualizing-a-vibrio-cholerae-o1-el-tor-typing-bacteriophage-belonging-to-the-myoviridae-group-and-the-packaging-of-its-genomic-ends-inside-the-phage-capsid
#11
Anindito Sen, Amar N Ghosh
Phage D10, an O1 El Tor tying vibriophage, has been successfully employed to tract the outspread of cholera epidemic. Using Transmission Electron Microscopy and computational image analysis, we have determined the structures of the capsid, head-to-tail connector, the contractile helical tail, the baseplate and combined them to form the complete three-dimensional (3D) D10 phage structure. Using partial denaturation experiments on the genome and using the computed 3D structure of the phage, we have established the packing of the genome ends inside the capsid together with the release styles during the phage infection, respectively...
October 17, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29034337/new-biomarkers-of-post-settlement-growth-in-the-sea-urchin-strongylocentrotus-purpuratus
#12
Alyaa Elsaid Abdelaziz Fadl, Magdy Elsayed Mahfouz, Mona Mabrouk Taha El-Gamal, Andreas Heyland
Some sea urchins, including the purple sea urchin Strongylocentrotus purpuratus, have been successfully used in aquaculture, but their slow growth and late reproduction are challenging to overcome when developing efficient aquaculture production techniques. S. purpuratus develops via an indirect life history that is characterized by a drastic settlement process at the end of a larval period that lasts for several weeks. During this transition, the bilateral larva is transformed into a pentaradial juvenile, which will start feeding and growing in the benthic habitat...
October 2017: Heliyon
https://www.readbyqxmd.com/read/29033968/dancing-with-hormones-a-current-perspective-of-nitrate-signaling-and-regulation-in-arabidopsis
#13
REVIEW
Peizhu Guan
In nature and agriculture, nitrate availability is a main environmental cue for plant growth, development and stress responses. Nitrate signaling and regulation are hence at the center of communications between plant intrinsic programs and the environment. It is also well known that endogenous phytohormones play numerous critical roles in integrating extrinsic cues and intrinsic responses, regulating and refining almost all aspects of plant growth, development and stress responses. Therefore, interaction between nitrate and phytohormones, such as auxins, cytokinins, abscisic acid, gibberellins, and ethylene, is prevalent...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29032418/transoral-robotic-surgery-for-squamous-cell-carcinomas-of-the-posterior-pharyngeal-wall
#14
B Lallemant, S Moriniere, P Ceruse, M Lebalch, K Aubry, S Hans, G Dolivet, O Malard, Q Bonduelle, S Vergez
Posterior pharyngeal wall squamous cell carcinomas (SCCs) are rare and have an associated poor prognosis. Progress in transoral resection techniques, in particular, transoral robotic surgery (TORS), have renewed the role of surgery in their treatment. This article presents the oncological and functional results obtained by the French Group of Head and Neck Robotic Surgery for TORS for posterior pharyngeal wall SCC-curative surgery. This retrospective, multicentre study presents data collected between September 2009 and November 2013 for patients treated with TORS for posterior pharyngeal wall SCCs...
October 14, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29029007/presence-of-micro-and-macroalbuminuria-and-the-association-with-cardiac-mechanics-in-patients-with-type-2-diabetes
#15
Peter Godsk Jørgensen, Tor Biering-Sørensen, Rasmus Mogelvang, Thomas Fritz-Hansen, Tina Vilsbøll, Peter Rossing, Jan Skov Jensen
Aims: Albuminuria-a marker of generalized vascular dysfunction-is a strong predictor of heart failure in patients with type 2 diabetes which may be caused by concomitant myocardial dysfunction reflecting the same underlying pathogenesis. Methods and results: We included 915 patients with type 2 diabetes from two secondary care centres and stratified according to albuminuria status in normo-, micro-, and macroalbuminuria. We performed comprehensive echocardiography including conventional imaging, tissue Doppler imaging, and 2D speckle tracking...
October 3, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29028937/abnormal-structural-brain-connectome-in-individuals-with-preclinical-alzheimer-s-disease
#16
Joana B Pereira, Danielle van Westen, Erik Stomrud, Tor Olof Strandberg, Giovanni Volpe, Eric Westman, Oskar Hansson
Alzheimer's disease has a long preclinical phase during which amyloid pathology and neurodegeneration accumulate in the brain without producing overt cognitive deficits. It is currently unclear whether these early disease stages are associated with a progressive disruption in the communication between brain regions that subsequently leads to cognitive decline and dementia. In this study we assessed the organization of structural networks in cognitively normal (CN) individuals harboring amyloid pathology (A+N-), neurodegeneration (A-N+), or both (A+N+) from the prospective and longitudinal Swedish BioFINDER study...
October 3, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29025685/generalization-of-learned-pain-modulation-depends-on-explicit-learning
#17
Leonie Koban, Daniel Kusko, Tor D Wager
The experience of pain is strongly influenced by contextual and socio-affective factors, including learning from previous experiences. Pain is typically perceived as more intense when preceded by a conditioned cue (CSHIGH) that has previously been associated with higher pain intensities, compared to cues associated with lower intensities (CSLOW). In three studies (total N=134), we tested whether this learned pain modulation generalizes to perceptually similar cues (Studies 1 and 2) and conceptually similar cues (Study 3)...
October 9, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/29024533/global-longitudinal-strain-corrected-by-rr-interval-is-a-superior-predictor-of-all-cause-mortality-in-patients-with-systolic-heart-failure-and-atrial-fibrillation
#18
Daniel Modin, Morten Sengeløv, Peter Godsk Jørgensen, Niels Eske Bruun, Flemming Javier Olsen, Maria Dons, Thomas Fritz Hansen, Jan Skov Jensen, Tor Biering-Sørensen
AIMS: Quantification of systolic function in patients with atrial fibrillation (AF) is challenging. A novel approach, based on RR interval correction, to counteract the varying heart cycle lengths in AF has recently been proposed. Whether this method is superior in patients with systolic heart failure (HFrEF) with AF remains unknown. This study investigates the prognostic value of RR interval-corrected peak global longitudinal strain {GLSc = GLS/[RR^(1/2)]} in relation to all-cause mortality in HFrEF patients displaying AF during echocardiographic examination...
October 11, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29020871/tolerability-and-safety-of-the-intravenous-immunoglobulin-octagam-%C3%A2-10-in-patients-with-immune-thrombocytopenia-a-post-authorisation-safety-analysis-of-two-non-interventional-phase-iv-trials
#19
Stefan Wietek, Daniel Svorc, Anette Debes, Tor-Einar Svae
OBJECTIVES: To provide detailed data on the tolerability and safety of octagam(®) 10%, a ready-to-use intravenous immunoglobulin, in a subgroup of patients with immune thrombocytopenia (ITP) involved in an integrated analysis of post-authorisation safety surveillance (PASS) studies. METHODS: A subgroup analysis was conducted using data collected from two non-interventional studies that included patients with ITP treated with octagam(®) 10%. Patients were observed and monitored for possible adverse drug reactions (ADRs) during or after administration of octagam(®) 10%, with a particular focus on thromboembolic events (TEEs)...
October 11, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29020221/systemic-inflammatory-response-to-malaria-during-pregnancy-is-associated-with-pregnancy-loss-and-preterm-delivery
#20
Michal Fried, Jonathan D Kurtis, Bruce Swihart, Sunthorn Pond-Tor, Amadou Barry, Youssoufa Sidibe, Santara Gaoussou, Moussa Traore, Sekouba Keita, Almahamoudou Mahamar, Oumar Attaher, Adama B Dembele, Kadidia B Cisse, Bacary S Diarra, Moussa B Kanoute, Alassane Dicko, Patrick E Duffy
Background: Pregnancy malaria (PM) is associated with a proinflammatory immune response characterized by increased levels of cytokines and chemokines such as tumor necrosis factor-α, interferon-γ, interleukin 10 (IL-10), and CXCL9. These changes are associated with poor outcomes including low birthweight delivery and maternal anemia. However, it is unknown if inflammatory pathways during malaria are related to pregnancy loss and preterm delivery (PTD). Methods: Cytokine and chemokine levels were measured in maternal peripheral blood at enrollment, gestational week 30-32, and delivery, and in placental blood, of 638 women during a longitudinal cohort study in Ouelessebougou, Mali...
July 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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