keyword
MENU ▼
Read by QxMD icon Read
search

Tor

keyword
https://www.readbyqxmd.com/read/29220665/mtorc1-activation-during-repeated-regeneration-impairs-somatic-stem-cell-maintenance
#1
Samantha Haller, Subir Kapuria, Rebeccah R Riley, Monique N O'Leary, Katherine H Schreiber, Julie K Andersen, Simon Melov, Jianwen Que, Thomas A Rando, Jason Rock, Brian K Kennedy, Joseph T Rodgers, Heinrich Jasper
The balance between self-renewal and differentiation ensures long-term maintenance of stem cell (SC) pools in regenerating epithelial tissues. This balance is challenged during periods of high regenerative pressure and is often compromised in aged animals. Here, we show that target of rapamycin (TOR) signaling is a key regulator of SC loss during repeated regenerative episodes. In response to regenerative stimuli, SCs in the intestinal epithelium of the fly and in the tracheal epithelium of mice exhibit transient activation of TOR signaling...
December 7, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/29220618/psychological-comfort-of-paramedics-with-field-death-pronouncement-a-national-asian-study-to-prepare-paramedics-for-field-termination-of-resuscitation
#2
Desmond R H Mao, Marcus E H Ong, Chungli Bang, Mohamed D T Salim, Yih Yng Ng, Desiree A Lie
OBJECTIVES: Paramedics' decision to terminate field resuscitation without a physician present may depend on personal and external factors. This study investigates factors associated with paramedic psychological comfort with termination of resuscitation (TOR) to inform future training. METHODS: We administered an anonymous survey to all practicing paramedics in a large urban Asian Emergency Medical Services system where formal TOR training had not yet been conducted and field TOR was not routinely applied...
December 8, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29214487/effects-of-dietary-poly-%C3%AE-hydroxybutyrate-phb-on-microbiota-composition-and-the-mtor-signaling-pathway-in-the-intestines-of-litopenaeus-vannamei
#3
Yafei Duan, Yue Zhang, Hongbiao Dong, Yun Wang, Jiasong Zhang
Poly-β-hydroxybutyrate (PHB) is a natural polymer of the short chain fatty acid β-hydroxybutyrate, which acts as a microbial control agent. The mammalian target of the rapamycin (mTOR) signaling pathway plays a crucial role in intestine inflammation and epithelial morphogenesis. In this study, we examined the composition of intestine microbiota, and mTOR signaling-related gene expression in Pacific white shrimp Litopenaeus vannamei fed diets containing different levels of PHB: 0% (Control), 1% (PHB1), 3% (PHB3), and 5% (PHB5) (w/w) for 35 days...
December 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29213282/determination-of-mammalian-target-of-rapamycin-hyperactivation-as-prognostic-factor-in-well-differentiated-neuroendocrine-tumors
#4
G Lamberti, C Ceccarelli, N Brighi, I Maggio, D Santini, C Mosconi, C Ricci, G Biasco, D Campana
Purpose: To evaluate the role of the activation of mTOR (phosphorylated mTOR, p-mTOR) and the expression SSTR2A and IGF-1R as prognostic factor in well-differentiated neuroendocrine tumors. Methods: A retrospective study was conducted on data from patients with diagnosis of neuroendocrine tumor originated from pancreas (pNET) or gastrointestinal tract (stomach, appendix, and ileus; GI-NET) made between January 2003 and December 2004 and followed up at our institution...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29211626/molecular-analyses-uncover-the-phylogenetic-placement-of-the-lichenized-hyphomycetous-genus-cheiromycina
#5
Lucia Muggia, Riccardo Mancinelli, Tor Tønsberg, Agnieszka Jablonska, Martin Kukwa, Zdeněk Palice
The genus Cheiromycina is one of the few genera of lichenized hyphomycetes for which no sexual reproductive stages have been observed. The genus includes species from boreal to temperate regions of the Northern Hemisphere where it is found growing on bark or wood. Congeners in Cheiromycina are characterized by a noncorticate thallus, nearly immersed in the substrate and presenting powdery unpigmented sporodochia, and containing chlorococcoid photobionts. The relationships of members of Cheiromycina with other fungi are not known...
November 1, 2017: Mycologia
https://www.readbyqxmd.com/read/29210134/socio-economic-status-and-physicians-treatment-decisions
#6
Kurt R Brekke, Tor Helge Holmås, Karin Monstad, Odd Rune Straume
This paper studies the relationship between patients' socio-economic status and general practitioners' (GPs') service provision by exploiting administrative patient-level data with information on consultation length, medical tests, and fee payments for each visit in Norway over a 5-year period (2008-2012). To reduce patient heterogeneity, we limit the sample to a given condition, diabetes type II, that is treated almost exclusively in primary care. We estimate GP fixed-effect models and control for a wide set of patient characteristics...
December 6, 2017: Health Economics
https://www.readbyqxmd.com/read/29209414/quantitative-in-vivo-phosphoproteomics-reveals-reversible-signaling-processes-during-nitrogen-starvation-and-recovery-in-the-biofuel-model-organism-chlamydomonas-reinhardtii
#7
Valentin Roustan, Shiva Bakhtiari, Pierre-Jean Roustan, Wolfram Weckwerth
Background: Nitrogen deprivation and replenishment induces massive changes at the physiological and molecular level in the green alga Chlamydomonas reinhardtii, including reversible starch and lipid accumulation. Stress signal perception and acclimation involves transient protein phosphorylation. This study aims to provide the first experimental phosphoprotein dataset for the adaptation of C. reinhardtii during nitrogen depletion and recovery growth phases and its impact on lipid accumulation...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29204586/transoral-robotic-surgery-for-obstructive-sleep-apnea-syndrome-principles-and-technique
#8
Claudio Vicini, Filippo Montevecchi, Riccardo Gobbi, Andrea De Vito, Giuseppe Meccariello
Objective: The present study is a review of transoral robotic surgery (TORS) for the treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods: The review presents the experience of the robotic center that developed the technique with regards to patient selection, surgical method, and post-operative care. In addition, the review provides results of a systematic review and meta-analysis of the complications and clinical outcomes of TORS when applied in the management of OSAHS...
June 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29200524/health-care-workers-occupational-exposures-to-body-fluids-in-21-countries-in-africa-systematic-review-and-meta-analysis
#9
REVIEW
Asa Auta, Emmanuel O Adewuyi, Amom Tor-Anyiin, David Aziz, Esther Ogbole, Brian O Ogbonna, Davies Adeloye
Objective: To estimate the lifetime and 12-month prevalence of occupational exposure to body fluids among health-care workers in Africa. Methods: Embase®, PubMed® and CINAHL databases were systematically searched for studies published between January 2000 and August 2017 that reported the prevalence of occupational exposure to blood or other body fluids among health-care workers in Africa. The continent-wide prevalence of exposure was estimated using random-effects meta-analysis...
December 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/29200426/characterization-of-dfoxo-binding-sites-upstream-of-the-insulin-receptor-p2-promoter-across-the-drosophila-phylogeny
#10
Dorcas J Orengo, Montserrat Aguadé, Elvira Juan
The insulin/TOR signal transduction pathway plays a critical role in determining such important traits as body and organ size, metabolic homeostasis and life span. Although this pathway is highly conserved across the animal kingdom, the affected traits can exhibit important differences even between closely related species. Evolutionary studies of regulatory regions require the reliable identification of transcription factor binding sites. Here we have focused on the Insulin Receptor (InR) expression from its P2 promoter in the Drosophila genus, which in D...
2017: PloS One
https://www.readbyqxmd.com/read/29199950/ragulator-and-gator1-complexes-promote-fission-yeast-growth-by-attenuating-tor-complex-1-through-rag-gtpases
#11
Kim Hou Chia, Tomoyuki Fukuda, Fajar Sofyantoro, Takato Matsuda, Takamitsu Amai, Kazuhiro Shiozaki
TOR complex 1 (TORC1) is an evolutionarily conserved protein kinase complex that promotes cellular macromolecular synthesis and suppresses autophagy. Amino acid-induced activation of mammalian TORC1 is initiated by its recruitment to the RagA/B-RagC/D GTPase heterodimer, which is anchored to lysosomal membranes through the Ragulator complex. We have identified in the model organism Schizosaccharomyces pombe a Ragulator-like complex that tethers the Gtr1-Gtr2 Rag heterodimer to the membranes of vacuoles, the lysosome equivalent in yeasts...
December 4, 2017: ELife
https://www.readbyqxmd.com/read/29196963/serum-lipid-and-bone-metabolism-effects-of-toremifene-vs-letrozole-as-adjuvant-therapy-for-postmenopausal-early-breast-cancer-patients-results-of-a-multicenter-open-randomized-study
#12
Tadahiko Shien, Hiroyoshi Doihara, Nobuaki Sato, Keisei Anan, Kansei Komaki, Keisuke Miyauchi, Yasuhiro Yanagita, Tomomi Fujisawa, Shoshu Mitsuyama, Chizuko Kanbayashi, Mikihiro Kusama, Morihiko Kimura, Hiromitsu Jinno, Muneaki Sano, Tadashi Ikeda
A prospective randomized phase II trial was conducted to evaluate the time course effects of toremifene (TOR) and letrozole (LET), as adjuvant hormone therapy, on serum lipid profiles and bone metabolism in estrogen receptor (ER)-positive, postmenopausal breast cancer patients.Fifty-four postmenopausal breast cancer patients [ER positive, HER2 negative, T1-2, node metastases (n = 0-3), M0] who had undergone curative resection were enrolled. They were randomized to receive either TOR 40 mg/day or LET 2...
December 1, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29196875/correction-to-associations-between-attention-deficit-hyperactivity-disorder-and-autoimmune-diseases-are-modified-by-sex-a-population-based-cross-sectional-study
#13
Tor-Arne Hegvik, Johanne Telnes Instanes, Jan Haavik, Kari Klungsøyr, Anders Engeland
The article "Associations between attention-deficit/hyperactivity disorder and autoimmune diseases are modified by sex: a population-based cross-sectional study", written by Tor-Arne Hegvik, Johanne Telnes Instanes, Jan Haavik, Kari Klungsøyr and Anders Engeland, was originally published electronically on the publisher's internet portal (currently SpringerLink) on October 5, 2017 without open access due to an error by the Springer editorial office in the processing of this article. The authors had originally opted for open access...
December 1, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29194991/hemorrhage-following-transoral-robotic-surgery-tors
#14
Ashley Hay, Jocelyn Migliacci, Daniella Karassawa Zanoni, Jay O Boyle, Bhuvanesh Singh, Richard J Wong, Snehal G Patel, Ian Ganly
BACKGROUND: To report our experience of postoperative hemorrhage in patients following transoral robotic surgery (TORS). METHODS: Data was collected on patients having TORS. Postoperative hemorrhage within 30 days was graded using the Mayo clinic grading system. RESULTS: TORS operations were performed on 122 patients. There were 23 bleeding events classified as minor to severe following 19 operations (16%). Hemorrhage requiring a return to the operating room occurred after 7 operations (6%)...
December 1, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29187279/upstream-signalling-of-mtorc1-and-its-hyperactivation-in-type-2-diabetes-t2d
#15
Muhammad Ali, Shazia Anwer Bukhari, Muhammad Ali, Han-Woong Lee
Mammalian target of rapamycin complex 1 (mTORC1) plays a major role in cell growth, proliferation, polarity, differentiation, development, and controls transitioning between anabolic and catabolic states of the cell. It collects almost all extracellular and intracellular signals from growth factors, nutrients, and maintains cellular homeostasis, and is involved in several pathological conditions including, neurodegeneration, Type 2 diabetes (T2D), obesity, and cancer. In this review, we summarize current knowledge of upstream signaling of mTORC1 to explain etiology of T2D and hypertriglyceridemia, in which state, the role of telomere attrition is explained...
October 30, 2017: BMB Reports
https://www.readbyqxmd.com/read/29183718/identification-and-characterization-of-pp2c-phosphatase-sjptc1-in-schistosoma-japonicum
#16
Yunfeng Lu, Yongwei Qin, Dandan Zhu, Aidi Shan, Jinrong Feng
Protein phosphorylation, regulated by protein kinases and protein phosphatases, is crucial for protein structure and function in eukaryotic organisms. Type 2C protein phosphatase (PP2C) belongs to the serine/threonine phosphatase family and its activities require the presence of a divalent magnesium or manganese ion. In the present study, a potential PP2C phosphatase (SjPtc1) was identified in Schistosoma japonicum. The SjPTC1 gene was found to be highly expressed in adult worms. A recombinant SjPtc1 protein showed typical PP2C phosphatase activity...
November 25, 2017: Parasitology International
https://www.readbyqxmd.com/read/29183011/transoral-robotic-surgery-with-sialendoscopy-for-a-plunging-ranula
#17
Ryan M Carey, Benjamin L Hodnett, Christopher H Rassekh, Gregory S Weinstein
BACKGROUND/AIMS: Plunging ranulas are oral mucoceles that often cannot be visualized directly and thus can be challenging to diagnose and differentiate from other neck lesions. Surgery is the preferred treatment option, but the optimal approach requires careful consideration. METHODS: We report the case of a plunging ranula presenting as an isolated neck mass in a 33-year-old patient. This patient was treated with a novel transoral robotic surgery (TORS)-assisted approach aided by sialendoscopy...
November 29, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29182490/positive-margins-by-oropharyngeal-subsite-in-transoral-robotic-surgery-for-t1-t2-squamous-cell-carcinoma
#18
Michael J Persky, William G Albergotti, Tanya J Rath, Mark W Kubik, Shira Abberbock, Mathew Geltzeiler, Seungwon Kim, Umamaheswar Duvvuri, Robert L Ferris
Objective To compare positive margin rates between the 2 most common subsites of oropharyngeal transoral robotic surgery (TORS), the base of tongue (BOT) and the tonsil, as well as identify preoperative imaging characteristics that predispose toward positive margins. Study Design Case series with chart review. Setting Tertiary care referral center. Subjects and Methods We compared the final and intraoperative positive margin rate between TORS resections for tonsil and BOT oropharyngeal squamous cell carcinoma (OPSCC), as well as the effect of margins on treatment...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29181932/cardiovascular-disease-and-diabetes-in-patients-with-african-or-asian-background
#19
Arild Aambø, Tor Ole Klemsdal
No abstract text is available yet for this article.
November 28, 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29181904/five-newly-recorded-cyprinid-fish-teleostei-cypriniformes-in-myanmar
#20
Tao Qin, Zhi-Ying Chen, Lu-Lu Xu, Paing Zaw, Yunn Mi Mi Kyaw, Kyaw Win Maung, Xiao-Yong Chen
Freshwater fish from the Putao and Myitkyina areas were collected in three ichthyofaunal surveys of the Mali Hka River and tributaries in and around Khakaborazi National Park and Hponkanrazi Wildlife Sanctuary, Kachin State, from 2014-2016. Tor yingjiangensis Chen et Yang 2004, Tor qiaojiensis Wu et al. 1977, Garra qiaojiensis Wu et al. 1977, Garra bispinosa Zhang 2005, and Schizothorax oligolepis Huang 1985, originally described from the upper Irrawaddy (Ayeyarwaddy) River in China, are first reported herein as new records to Myanmar...
September 18, 2017: Zoological Research
keyword
keyword
80304
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"