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https://www.readbyqxmd.com/read/29458129/honeysuckle-encoded-microrna2911-inhibits-enterovirus-71-replication-via-targeting-vp1-gene
#1
Xihan Li, Ying Huang, Menghuai Sun, Hong Ji, Hui Dou, Jia Hu, Yanfeng Yan, Xu Wang, Leiyao Chen
Enterovirus 71 (EV71) is the primary pathogen of hand-foot-and-mouth disease (HFMD) in children and virus infections are associated with severe neurological dysfunctions and even death. MIR2911 is a honeysuckle-encoded atypical microRNA with extremely stability. Here, we report that MIR2911 directly inhibits EV71 replication by targeting the VP1 gene. Bioinformatics prediction and luciferase reporter assay showed that MIR2911 could target the VP1 gene of EV71. Transfection experiments using synthetic MIR2911 and extracted RNA from HS decoction shown that each of these preparations was capable of inhibiting EV71 VP1 protein expression; however, these preparations did not impact EV71 mutants in which the MIR2911-binding sites were mutated...
February 16, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29457428/-percutaneous-poking-reduction-with-bone-grafting-and-limited-internal-fixation-for-the-treatment-of-calcaneal-fractures
#2
Hua Chen, Yu-Wei Li, Hong Jiang, Zhi-Gang Zhang, Bin-Jie Lu
OBJECTIVE: To investigate clinical effects of percutaneous poking reduction with bone grafting and limited internal fixation for the treatment of calcaneal fractures. METHODS: From May 2013 to October 2016, 53 patients with closed calcaneal fractures were analyzed, and were divided into treatment group and control group. There were 33 patients in treatment group including 25 males and 8 females, aged from 15 to 82 years old with an average of(44.7±14.2) years old; 17 cases were type II and 16 cases were type III according to Sanders classification; treated by percutaneous poking reduction with bone grafting and limited internal fixation...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457399/-osseous-bridge-resection-for-the-treatment-of-adult-talocalaneal-coalitions-without-arthritis
#3
Bing Xie, Shuo Yan, Hao Zhang, Yuan-Wei Wang, Jing Tian
OBJECTIVE: To analyze clinical outcomes of osseous-bridge resection for the treatment of adult symptomatic talocalcaneal coalitions without arthritis. METHODS: The clinical data of 12 patients (15 feet) with symptomatic talocalcaneal coalitions without arthtitis from January 2013 to June 2016 were respectively analyzed. All cases were secondary talocalcaneal coalition. There were 9 males (11 feet) and 3 females (4 feet) with a mean (26.6±3.3) years old (ranged, 18 to 33 years old)...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457368/emergence-of-two-novel-sublineages-ind2001bd1-and-ind2001bd2-of-foot-and-mouth-disease-virus-serotype-o-in-bangladesh
#4
M A Siddique, M R Ali, A S M R U Alam, H Ullah, A Rahman, R P Chakrabarty, M A Amin, S A Hoque, S P Nandi, M Sultana, M A Hossain
Foot-and-mouth disease (FMD) is endemic in Bangladesh, and the implementation of a control programme for this disease is at an early stage, according to the FAO- and OIE-proposed Progressive Control Pathway for FMD (PCP-FMD) Roadmap. To develop an effective control programme, understanding of foot-and-mouth disease virus (FMDV) serotypes, even subtypes within the serotypes is essential. The present investigation aims at viral VP1 coding region sequence-based analysis of FMD samples collected from 34 FMD outbreaks during 2012-2016 in Bangladesh...
February 18, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29457299/t1%C3%AF-mapping-of-articular-cartilage-grafts-after-autologous-osteochondral-transplantation-for-osteochondral-lesions-of-the-talus-a-longitudinal-evaluation
#5
Naoki Haraguchi, Koki Ota, Naoki Nishida, Takuma Ozeki, Takashige Yoshida, Atsushi Tsutaya
BACKGROUND: Clinical results of autologous osteochondral transplantation (AOT) for treatment of osteochondral lesions of the talus have been mixed. T1ρ imaging can be used to noninvasively detect early cartilage degeneration. PURPOSE OR HYPOTHESIS: To quantitatively assess, by means of T1ρ imaging, changes over time in the biochemical health of grafted cartilage after AOT for osteochondral lesions of the talus. STUDY TYPE: Retrosepctive case series...
February 19, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29457021/difficult-renal-pathological-classification-in-a-case-of-pediatric-nephrotic-syndrome
#6
Hiroshi Yamaguchi, Atsutoshi Shiratori, Taku Nakagawa, Kyoko Kanda, Shigeo Hara, Norishige Yoshikawa, Ryojiro Tanaka
The underlying histopathology is very important in determining patient management, as the histopathology usually has direct repercussions on the treatment response and clinical course. However, the impact of the method used to assess renal biopsies, i.e., light microscopy (LM), immunofluorescence (IF), and electron microscopy (EM), on the occurrence of a difficult biopsy classification in the native kidneys of pediatric nephrotic patients is unknown. A 12-month-old Japanese boy was diagnosed with nephrotic syndrome (NS); he was administered prednisolone (60 mg/m2 /day), and a continuous albumin infusion was started...
September 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29456759/ossification-of-the-phalanges-of-the-foot-and-its-relationship-to-peak-height-velocity-and-the-calcaneal-system
#7
M R Garcia, A D Nicholson, A M Nduaguba, J O Sanders, R W Liu, D R Cooperman
Purpose: There are multiple skeletal maturity grading systems, but none of them utilizes the phalanges of the foot. To minimize radiation, it would be ideal if one could assess the skeletal maturity of a foot based on bones seen on routine foot radiographs, if guided growth is being considered as a treatment option. We developed a system that correlates changes of the appearance of the foot phalanges to peak height velocity (PHV) and the recently described calcaneal apophyseal ossification grading system...
February 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29456758/binary-and-analogue-markers-of-skeletal-maturity-clinical-utility-of-the-thenar-and-plantar-sesamoids
#8
A D Nicholson, J O Sanders, R W Liu, D R Cooperman
Purpose: We investigate the thenar and plantar sesamoids as markers of skeletal maturity, and grade appearance using two scales, a binary system (absent or present), and an analogue system that relies upon judging regular changes in morphological appearance. Methods: We studied 94 healthy children (49 female and 45 male patients) between ages three and 18 years who had approximately 700 serially acquired sets of radiographs and physical examinations. The children had at least annual radiographs taken of the left hand and left foot...
February 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29456448/pain-catastrophizing-mediates-the-relationship-between-trait-happiness-and-depressive-symptoms-in-individuals-with-current-pain
#9
Patrick Tran, John A Sturgeon, Aneesha Nilakantan, Alyssa Foote, Sean Mackey, Kevin Johnson
Objective: There is an extensive relationship between chronic pain and depression; however, there is less research examining whether pain-specific factors, such as pain intensity, predict depression, above and beyond the role of normative factors, such as positive emotions. The current study characterized the independent contributions of pain intensity, pain catastrophizing, and a trait measure of happiness to self-rated depressive symptoms. Methods: We recruited and enrolled 70 volunteers across 3 groups of participants: two groups of patients with current low back pain (one group on opioids and one group opioid-naïve), and individuals in a methadone maintenance treatment program...
December 2017: Journal of Applied Biobehavioral Research
https://www.readbyqxmd.com/read/29456226/three-cases-of-prune-belly-syndrome-at-the-lagos-state-university-teaching-hospital-ikeja
#10
Adaobi U Solarin, Elizabeth A Disu, Henry O Gbelee, Adeola B Animasahaun, Oluwatosin E Aremu, Eucharia Ogbuokiri, Gbemisola O Ogunnaike, Alaba Oladimeji
Prune belly syndrome (PBS) is a rare congenital disorder affecting 2.5 to 3.8/100,000 live births worldwide. Our objective of this report is to describe clinical manifestation, laboratory, and radiological characteristics of PBS in our patients, to highlight the limitations to offering appropriate patient care due to parents demanding discharge against medical advice and the need to increase the awareness regarding this rare disease. We report three cases; all referred after birth with lax abdominal wall, congenital anomalies of kidney, and urinary tract...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456169/kinematics-of-lower-limbs-during-walking-are-emulated-by-springy-walking-model-with-a-compliantly-connected-off-centered-curvy-foot
#11
Hyerim Lim, Sukyung Park
The dynamics of the center of mass (CoM) during walking and running at various gait conditions are well described by the mechanics of a simple passive spring loaded inverted pendulum (SLIP). Due to its simplicity, however, the current form of the SLIP model is limited at providing any further information about multi-segmental lower limbs that generate oscillatory CoM behaviors and their corresponding ground reaction forces. Considering that the dynamics of the CoM are simply achieved by mass-spring mechanics, we wondered whether any of the multi-joint motions could be demonstrated by simple mechanics...
February 8, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29456146/a-comprehensive-and-dated-phylogenomic-analysis-of-butterflies
#12
Marianne Espeland, Jesse Breinholt, Keith R Willmott, Andrew D Warren, Roger Vila, Emmanuel F A Toussaint, Sarah C Maunsell, Kwaku Aduse-Poku, Gerard Talavera, Rod Eastwood, Marta A Jarzyna, Robert Guralnick, David J Lohman, Naomi E Pierce, Akito Y Kawahara
Butterflies (Papilionoidea), with over 18,000 described species [1], have captivated naturalists and scientists for centuries. They play a central role in the study of speciation, community ecology, biogeography, climate change, and plant-insect interactions and include many model organisms and pest species [2, 3]. However, a robust higher-level phylogenetic framework is lacking. To fill this gap, we inferred a dated phylogeny by analyzing the first phylogenomic dataset, including 352 loci (> 150,000 bp) from 207 species representing 98% of tribes, a 35-fold increase in gene sampling and 3-fold increase in taxon sampling over previous studies [4]...
February 14, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29456065/endoscopy-assisted-hallux-valgus-correction-provides-sustainable-long-term-10-year-outcomes
#13
Samuel K K Ling, Tun Hing Lui
PURPOSE: This study aims to review the long-term efficacy of the endoscopy-assisted distal soft-tissue procedure (EDSTP) and to see whether operative correction can be maintained for >10 years. METHODS: All hallux valgus cases undergoing EDSTP from 2000 to 2006 were recruited. Preoperative, postoperative, and 10-year follow-up x-rays were analyzed. A pain score from the preoperative and >10-year follow-up was recorded. The American Orthopaedic Foot and Ankle Society (AOFAS) hallux score and Foot and Ankle Outcome Score (FAOS) were measured at the >10-year follow-up...
February 15, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29455631/periosteal-flap-augmentation-of-the-modified-brostr%C3%A3-m-gould-procedure-for-chronic-lateral-ankle-instability
#14
Chee Ping Chew, Kevin Oon Thien Koo, Denny Tjiauw Tjoen Lie
INTRODUCTION: Chronic lateral ankle instability occurs in up to 20% of ankle injuries. Most can be treated conservatively, but surgical reconstruction is required if conservative treatment fails. Modified Broström-Gould procedure is an effective surgical treatment and the augmentation of this procedure with a periosteal flap may confer additional stability. We report on the outcome of a technique combining a modified Broström-Gould procedure augmented with a periosteal flap in patients with chronic lateral ankle instability...
January 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29455511/-treatment-of-gouty-arthritis-of-the-first-metatarsophalangeal-joint-by-masquelet-technique
#15
Cheng-Lin Wang, Jun-Zhong Yang
OBJECTIVE: To study clinical curative effects of a Masquelet technology in the treatment of gouty arthritis in the first metatarsophalangeal joint. METHODS: From February 2012 to May 2016, 7 patients with the gouth arthritis of the first metatarsophalangeal joint were treated by the Masqueket technology. There were 5 males and 2 females, ranging in age from 42 to 58 years old, with an average age of 50 years old. During the regular follow up, the bone healing was assessed by the radiographic imaging, and the orthopaedic foot and ankle Association (AOFAS) ankle function scoring system was used for comprehensive evaluation...
August 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455509/-treatment-of-sanders-ii-calcaneus-fractures-via-minimally-invasive-sinus-tarsi-approach
#16
Xue-Xun Bao, Chen-Jie Xia, Bi-Yun Zhao, De-Jun Shi, Guan-Hua Lan, Guo-Lin Ren, Zu-Hong Xie, Wen-Xi Du
OBJECTIVE: To study the feasibility and clinical efficacy of a minimally invasive sinus tarsi approach in the treatment of Sanders II calcaneus fractures. METHODS: From August of 2015 to July of 2016, 13 patients(totally 13 feet) with Sanders II intra-articular calcaneus fractures were treated via the minimally invasive sinus tarsi approach. The Böhler angle, Gissane angle and the length, width and height of calcaneus were compared between pre-operation and post-operation...
August 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455421/impact-of-baseline-characteristics-on-outcomes-of-advanced-hcc-patients-treated-with-sorafenib-a-secondary-analysis-of-a-phase-iii-study
#17
Omar Abdel-Rahman
BACKGROUND: The current study aims to investigate the impact of baseline characteristics on the outcomes of sorafenib-treated advanced Hepatocellular carcinoma (HCC) patients in the setting of a clinical trial. METHODS: This is a secondary analysis of the comparator arm (sorafenib arm) of the NCT00699374 study which is a phase III multicenter study conducted between 2008 and 2010. The univariate probability of overall and progression-free survival was assessed among different patient subsets through Kaplan-Meier analysis and log-rank testing...
February 17, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29455065/foot-and-mouth-disease-virus-type-o-specific-mutations-determine-rna-dependent-rna-polymerase-fidelity-and-virus-attenuation
#18
Chen Li, Haiwei Wang, Tiangang Yuan, Andrew Woodman, Decheng Yang, Guohui Zhou, Craig E Cameron, Li Yu
Previous studies have shown that the FMDV Asia1/YS/CHA/05 high-fidelity mutagen-resistant variants are attenuated (Zeng et al., 2014). Here, we introduced the same single or multiple-amino-acid substitutions responsible for increased 3Dpol fidelity of type Asia1 FMDV into the type O FMDV O/YS/CHA/05 infectious clone. The rescued viruses O-DA and O-DAMM are lower replication fidelity mutants and showed an attenuated phenotype. These results demonstrated that the same amino acid substitution of 3Dpol in different serotypes of FMDV strains had different effects on viral fidelity...
February 15, 2018: Virology
https://www.readbyqxmd.com/read/29455014/cilostazol-improves-wound-healing-in-patients-undergoing-open-bypass-for-ischemic-tissue-loss-a-propensity-score-matching-analysis
#19
Shinsuke Mii, Atsushi Guntani, Eisuke Kawakubo, Kiyoshi Tanaka, Ryoichi Kyuragi
BACKGROUND: Few reports have described the effects of medication on the wound healing of ischemic ulcers after revascularization. This study was conducted to investigate the effects of cilostazol on wound healing in patients who underwent infrainguinal bypass for ischemic tissue loss. METHODS: Two hundred and sixty-three limbs undergoing de novo infrainguinal bypass for tissue loss from January 2004 to December 2015 were divided into two groups based on whether or not cilostazol was administered after surgery...
February 15, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29454975/prefrontal-cortex-activation-during-obstacle-negotiation-what-s-the-effect-size-and-timing
#20
Inbal Maidan, Shiran Shustak, Topaz Sharon, Hagar Bernad-Elazari, Nimrod Geffen, Nir Giladi, Jeffrey M Hausdorff, Anat Mirelman
BACKGROUND: Obstacle negotiation is a daily activity that requires the integration of sensorimotor and cognitive information. Recent studies provide evidence for the important role of prefrontal cortex during obstacle negotiation. We aimed to explore the effects of obstacle height and available response time on prefrontal activation. METHODS: Twenty healthy young adults (age: 30.1 ± 1.0 years; 50% women) walked in an obstacle course while negotiating anticipated and unanticipated obstacles at heights of 50 mm and 100 mm...
February 15, 2018: Brain and Cognition
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