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https://www.readbyqxmd.com/read/29928559/clinical-etiological-anatomical-and-bacteriological-study-of-diabetic-foot-patients-results-of-a-single-center-study
#1
Ashwinikumar Patil, Datta More, Anant Patil, Kishor A Jadhav, Myriam E Vijil Mejia, Suresh S Patil
OBJECTIVE: To examine the clinical pattern of foot-related complications in type 2 diabetes patients. MATERIAL AND METHODS: A cross-sectional study was conducted among indoor, adult type 2 diabetes patients with risk factors for diabetic foot complications. The diabetic neuropathy symptom score (DNSS), Doppler scanning, ankle brachial pressure index (ABPI) assessment, neuropathy assessment, neuropathic disability score (NDS), biothesiometry evaluation, and bacteriological examination was performed...
April 18, 2018: Curēus
https://www.readbyqxmd.com/read/29928316/uk-podiatrists-experiences-of-podiatry-services-for-people-living-with-arthritis-a-qualitative-investigation
#2
Louise McCulloch, Alan Borthwick, Anthony Redmond, Katherine Edwards, Rafael Pinedo-Villanueva, Daniel Prieto-Alhambra, Andrew Judge, Nigel K Arden, Catherine J Bowen
Background: Provision of podiatry services, like other therapies in the UK, is an area that lacks guidance by the National Institute for Health and Care Excellence. Many individuals living with arthritis in the UK are not eligible to access NHS podiatry services. The primary aim of this investigation was to understand the views of podiatry clinicians on their experiences of referral, access, provision and treatment for foot problems for patients who have arthritis. Methods: Focus groups were undertaken to explore, in-depth, individual views of podiatrists working in the UK to gain feedback on experiences of barriers and facilitators to referral, access, provision and treatment for foot problems for individuals living with arthritis...
2018: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29928201/efficacy-and-tolerability-of-topical-green-tea-extract-polyphenon-e-application-in-a-therapy-resistant-plantar-wart
#3
Giancarlo Meloni, Massimo Milani
Plantar warts account for 30% of all cutaneous warts. These lesions could be very painful, especially if the lesion is located over pressure sites such as the metatarsal head. Plantar wart treatment remains a challenging therapeutic problem. A 67-year-old immunocompetent nonsmoking man presented with a large mosaic plantar wart on his right foot. The lesion had been present for 5 years. Several cryotherapy sessions (a total of 6 procedures) had been performed with no success. The lesion was therefore treated with a 5-fluorouracil (5-FU) regimen and then with a topical combination of 5-FU and salicylic acid, but also these approaches failed...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29928132/efficacy-and-safety-of-sorafenib-versus-apatinib-in-the-treatment-of-intermediate-and-advanced-hepatocellular-carcinoma-a-comparative-retrospective-study
#4
Yizhuo Wang, Qing Gou, Rongde Xu, Xiaoming Chen, Zejian Zhou
Objective: To compare the efficacy and safety profiles of sorafenib and apatinib in patients with intermediate- and advanced-stage hepatocellular carcinoma (HCC). Methods: This was a single-center, retrospective study where we collected the clinical data of 72 patients, diagnosed with intermediate or advanced HCC from January 2014 to December 2016. Depending on the treatment received, 38 patients were categorized into group S (sorafenib group) and 34 into group A (apatinib group)...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29928104/a-case-report-on-rare-occurrence-of-periosteal-ganglion-cyst-in-femoral-intercondylar-region
#5
Padmanabh H Vora, Neel M Bhavsar, Rameez Musa, Ajay Trivedi, Prarthan Amin
Ganglions are the cysts derived from myxomatous degeneration of periarticular tissue, commonly found around wrist and foot. Ganglion cysts are uncommon in Knee region and if present their occurrence is mostly incidental and benign. Based on their location, this could be extraarticular or intraarticular. Lesions with similar pathology in subchondral region around joints are lesser common entity called Intraosseous ganglions. Rarer still is the lesion produced by myxomatous degeneration of periosteum of long bone, called periosteal ganglion...
June 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29926741/down-regulation-of-telomerase-reverse-transcriptase-related-anti-apoptotic-function-in-a-rat-model-of-acrylamide-induced-neurobehavioral-deficits
#6
J Wang, M Y Zhang, S Q Xu, J Cheng, Z J Yu, X M Hu
Although the precise mechanism is unknown, neuron apoptosis is believed to participate in neuropathy caused by acrylamide (ACR). Telomerase reverse transcriptase (TERT) exhibits an anti-apoptotic function, but its contribution to the pathogenesis of ACR neurotoxicity is unclear. We investigated adult male rats that were given 30, 40 and 50 mg/kg ACR three times/week for 4 weeks. We found that ACR treatment caused significant deficits in sensory/motor function as measured by gait score, landing foot spread distance, movement initiation test and tail immersion test...
June 21, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29925502/2018-consensus-statement-on-exercise-therapy-and-physical-interventions-orthoses-taping-and-manual-therapy-to-treat-patellofemoral-pain-recommendations-from-the-5th-international-patellofemoral-pain-research-retreat-gold-coast-australia-2017
#7
Natalie J Collins, Christian J Barton, Marienke van Middelkoop, Michael J Callaghan, Michael Skovdal Rathleff, Bill T Vicenzino, Irene S Davis, Christopher M Powers, Erin M Macri, Harvi F Hart, Danilo de Oliveira Silva, Kay M Crossley
Patellofemoral pain affects a large proportion of the population, from adolescents to older adults, and carries a substantial personal and societal burden. An international group of scientists and clinicians meets biennially at the International Patellofemoral Research Retreat to share research findings related to patellofemoral pain conditions and develop consensus statements using best practice methods. This consensus statement, from the 5th International Patellofemoral Research Retreat held in Australia in July 2017, focuses on exercise therapy and physical interventions (eg, orthoses, taping and manual therapy) for patellofemoral pain...
June 20, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29925360/hand-foot-mouth-disease-and-use-of-steroids-intravenous-immunoglobulin-and-traditional-chinese-herbs-in-a-tertiary-hospital-in-shantou-china
#8
Dangui Zhang, Jieling Chen, William Ba-Thein
BACKGROUND: In contrast to the guidelines of World Health Organization (WHO) and United States-Centers for Disease Control and prevention (US-CDC), the Chinese national guidelines recommend the use of steroids, intravenous immunoglobulin (IVIG), or traditional Chinese herbs (TCHs) in hand-foot-mouth disease (HFMD) management. Their use and therapeutic efficacies are, however, unclear. We aimed to describe their use in and the clinical outcomes of hospitalized HFMD cases. METHODS: A retrospective review of hospital medical records for HFMD cases during 2008-2016 was conducted in a medical school-affiliated tertiary hospital in Shantou, Guangdong, China...
June 20, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29925032/transition-from-actin-driven-to-water-driven-cell-migration-depends-on-external-hydraulic-resistance
#9
Yizeng Li, Sean X Sun
Cells in vivo can reside in diverse physical and biochemical environments. For example, epithelial cells typically live in a two-dimensional (2D) environment, whereas metastatic cancer cells can move through dense three-dimensional matrices. These distinct environments impose different kinds of mechanical forces on cells and thus potentially can influence the mechanism of cell migration. For example, cell movement on 2D flat surfaces is mostly driven by forces from focal adhesion and actin polymerization, whereas in confined geometries, it can be driven by water permeation...
June 19, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29924795/nephrin-is-necessary-for-podocyte-recovery-following-injury-in-an-adult-mature-glomerulus
#10
Rakesh Verma, Madhusudan Venkatareddy, Anne Kalinowski, Theodore Li, Joanna Kukla, Ashomathi Mollin, Gabriel Cara-Fuentes, Sanjeevkumar R Patel, Puneet Garg
Nephrin (Nphs1) is an adhesion protein that is expressed at the podocyte intercellular junction in the glomerulus. Nphs1 mutations in humans or deletion in animal genetic models results in a developmental failure of foot process formation. A number of studies have shown decrease in expression of nephrin in various proteinuric kidney diseases as well as in animal models of glomerular disease. Decrease in nephrin expression has been suggested to precede podocyte loss and linked to the progression of kidney disease...
2018: PloS One
https://www.readbyqxmd.com/read/29924790/-surgical-treatment-of-total-thrombosis-of-an-abdominal-aortic-endograft
#11
V V Shlomin, I V Kas'ianov, I G Drozhzhin, P B Bondarenko, P D Puzdriak
Described in the article is a clinical case report regarding successful surgical treatment of total thrombosis of a stent graft in a high-risk surgical patient, having previously undergone endovascular repair of an abdominal aortic aneurysm by means of a unilateral stent graft with suprarenal fixation of its crown and femorofemoral crossover bypass grafting. 5 months after the operation, the patient began complaining of rest pain in his right leg and trophic ulcers of the foot. The findings of MSCT angiography revealed total thrombosis of the stent graft, to be later on followed by operative intervention, i...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924718/case-255-foot-binding
#12
Adeline Mei-Yen Yong, Paul A Tambyah
History A 99-year-old Chinese-Indonesian woman with a longstanding history of diabetes mellitus was admitted for chest infection and was incidentally found to have bilateral deformed feet. She was otherwise asymptomatic and could ambulate independently. Photographs and radiographs of the feet were obtained.
July 2018: Radiology
https://www.readbyqxmd.com/read/29924429/number-location-and-time-since-prior-fracture-as-predictors-of-future-fracture-in-elderly-from-the-general-population
#13
Claudia Beaudoin, Sonia Jean, Lynne Moore, Philippe Gamache, Louis Bessette, Louis-Georges Ste-Marie, Jacques P Brown
Prognostic tools are available to identify individuals at high risk of osteoporotic fracture and assist physicians in management decisions. Some authors have suggested improving the predictive ability of current tools by integrating characteristics of prior fractures (number, location and time since prior fracture). The objectives of this study were i) to evaluate the sex-age-specific association between characteristics of prior fractures and the occurrence of a future osteoporotic fracture and ii) to assess whether the characteristics of prior fractures could increase the discriminative ability of fracture risk prediction tools...
June 20, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29924336/effects-of-cryotherapy-on-objective-and-subjective-symptoms-of-paclitaxel-induced-neuropathy-prospective-self-controlled-trial
#14
Akiko Hanai, Hiroshi Ishiguro, Takashi Sozu, Moe Tsuda, Ikuko Yano, Takayuki Nakagawa, Satoshi Imai, Yoko Hamabe, Masakazu Toi, Hidenori Arai, Tadao Tsuboyama
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting and disabling side effect of taxane anticancer agents. We prospectively evaluated the efficacy of cryotherapy for CIPN prevention. Methods: Breast cancer patients treated weekly with paclitaxel (80 mg/m2 for one hour) wore frozen gloves and socks on the dominant side for 90 minutes, including the entire duration of drug infusion. Symptoms on the treated sides were compared with those on the untreated (nondominant) sides...
February 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29924227/solitary-plantar-basal-cell-carcinoma
#15
Maura Simonetti Junqueira Bourroul, Ludmila Lopes Trindade, Vanessa Soares do Nascimento, Anderson da Costa Lino Costa, Ubirajara Honorato da Silva
Basal cell carcinoma is the most frequent skin cancer, generally located in hair-bearing, sunlight-exposed areas. Basal cell carcinoma usually occurs on the head and neck, but very rarely on extra-facial locations. We report a case of a 65-year-old woman presenting with a solitary non-healing ulcer on the sole of the right foot for two years. Histopathological examination showed a typical nodular basal cell carcinoma, confirmed by positivity to Ber-EP4 on immunohistochemistry. There was no history of trauma, exposure to noxious agents, basal cell nevus syndrome, or xeroderma pigmentosum...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29924215/recurrent-skin-ulcer-cross-repair-and-sensory-reconstruction-in-a-wrn-gene-mutational-patient
#16
Jiqiang He, Ding Pan, Panfeng Wu, Juyu Tang
A 37-year-old man complained of a refractory posterior malleolar ulceration on his left ankle. He was diagnosed with Werner syndrome according to the progeroid clinical features and genetic testing. To approach the ulceration, a free flow-through right anterolateral thigh perforator flap with anterolateral thigh cutaneous nerve was harvested. One year later, he was readmitted due to a new ulceration on his right ankle. We harvested the left anterolateral thigh perforator flap with anterolateral thigh cutaneous nerve to reconstruct the defect...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29923985/tarsal-tunnel-syndrome-caused-by-an-uncommon-ossicle-of-the-talus-a-case-report
#17
Chang Hwa Hong, Young Koo Lee, Sung Hun Won, Dhong Won Lee, Sang Il Moon, Woo Jong Kim
RATIONALE: Tarsal tunnel syndrome (TTS) is a compressive neuropathy of the posterior tibial nerve or one of its branches within the tarsal tunnel that is often caused by a variety of space-occupying lesions, such as ganglia, lipomas, varicosities, neural tumors, trauma, or systemic disease. The os sustentaculi is a small accessory bone, bridged to the posterior aspect of the sustentaculum tali by fibrocartilage. To the best of our knowledge, this is a rare case of successful treatment of TTS caused by the os sustantaculi...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923767/the-protective-role-of-trpc6-knockout-in-the-progression-of-diabetic-kidney-disease
#18
Denisha Spires, Daria V Ilatovskaya, Vladislav Levchenko, Paula E North, Aron M Geurts, Oleg Palygin, Alexander Staruschenko
Diabetic kidney disease (DKD) is a chronic kidney pathology that leads to end stage renal disease. Previous studies from our laboratory indicate that there is an association between the development of DKD and the TRPC6 channel. Trpc6 expression and activity was increased in the streptozotocin (STZ)-treated Dahl Salt-sensitive (SS) rat, an established model of type 1 diabetes. Here, using a Trpc6 knock-out created on the SS rat background (SSTRPC6-/- ), we test the hypothesis that the absence of Trpc6 will protect podocytes and kidney function during the development of DKD...
June 20, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29923758/in-vivo-ct-analysis-of-physiological-fibular-motion-at-the-level-of-the-ankle-syndesmosis-during-plantigrade-weightbearing
#19
Paul Hoogervorst, Zachary M Working, Ashraf N El Naga, Meir Marmor
BACKGROUND: It is clear that motion at the syndesmosis occurs due to ranging of the ankle joint, but the influence of weightbearing with the foot in the plantigrade position is unclear. In vivo computed tomographic (CT) evaluation of the syndesmosis has not been previously described. The purpose of this study is to quantify physiological fibular motion at the level of the ankle syndesmosis in both weightbearing and nonweightbearing conditions with the foot in the plantigrade position...
June 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29923750/cost-utility-analyses-in-us-orthopaedic-foot-and-ankle-surgery-a-systematic-review
#20
Aditya V Karhade, John Y Kwon
BACKGROUND: While investigations have been performed examining the quality of US-based cost-utility analyses for other orthopaedic subspecialties and have provided important insights, a similar analysis has not been performed examining the foot and ankle literature. METHODS: A systematic review of foot and ankle studies was conducted to identify cost-utility analyses published between 2000 and 2017. Of 687 studies screened by abstract, 4 cost-utility studies were identified and scored by the Quality of Health Economic Studies instrument...
June 1, 2018: Foot & Ankle Specialist
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