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Wingless regeneration

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https://www.readbyqxmd.com/read/29615557/wingless-wnt-signaling-in-intestinal-development-homeostasis-regeneration-and-tumorigenesis-a-drosophila-perspective
#1
REVIEW
Ai Tian, Hassina Benchabane, Yashi Ahmed
In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis...
March 28, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29567480/wnt3-and-gata4-regulate-axon-regeneration-in-adult-mouse-drg-neurons
#2
Run-Shan Duan, Pei-Pei Liu, Feng Xi, Wei-Hua Wang, Gang-Bin Tang, Saijilafu, Rui-Ying Wang, Chang-Mei Liu
Neurons in the adult central nervous system (CNS) have a poor intrinsic axon growth potential after injury, but the underlying mechanisms are largely unknown. Wingless-related mouse mammary tumor virus integration site (WNT) family members regulate neural stem cell proliferation, axon tract and forebrain development in the nervous system. Here we report that Wnt3 is an important modulator of axon regeneration. Downregulation or overexpression of Wnt3 in adult dorsal root ganglion (DRG) neurons enhances or inhibits their axon regeneration ability respectively in vitro and in vivo...
March 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29563503/cell-fate-changes-induced-by-a-distal-less-enhancer-trap-transgene-in-the-drosophila-antennal-imaginal-disc
#3
Syeda Nayab Fatima Abidi, Rachel K Smith-Bolton
The imaginal discs of the genetically tractable model organism Drosophila melanogaster have been used to study cell-fate specification and plasticity, including homeotic changes and regeneration-induced transdetermination. The identity of the reprogramming mechanisms that induce plasticity has been of great interest in the field. Here we identify a change from antennal fate to eye fate induced by a Distal-less-GAL4 (DllGAL4) P-element insertion that is a mutant allele of Dll and expresses GAL4 in the antennal imaginal disc...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29372681/ctbp-impedes-jnk-and-upd-stat-driven-cell-fate-misspecifications-in-regenerating-drosophila-imaginal-discs
#4
Melanie I Worley, Larissa A Alexander, Iswar K Hariharan
Regeneration following tissue damage often necessitates a mechanism for cellular re-programming, so that surviving cells can give rise to all cell types originally found in the damaged tissue. This process, if unchecked, can also generate cell types that are inappropriate for a given location. We conducted a screen for genes that negatively regulate the frequency of notum-to-wing transformations following genetic ablation and regeneration of the wing pouch, from which we identified mutations in the transcriptional co-repressor C-terminalBinding Protein (CtBP)...
January 26, 2018: ELife
https://www.readbyqxmd.com/read/29129556/mechanisms-of-rhoa-inactivation-and-cdc42-and-rac1-activation-during-zebrafish-optic-nerve-regeneration
#5
Toru Matsukawa, Kazune Morita, Shou Omizu, Satoru Kato, Yoshiki Koriyama
When axons of the mammalian central nervous system (CNS) are injured, they fail to regenerate, while those of lower vertebrates undergo regeneration after injury. Wingless-type MMTV integration site family (Wnt) proteins play important roles in the CNS, and are reported to be activated after mammalian spinal cord or brain injury. Moreover, for axon growth to proceed, it is thought that small G-proteins, such as CDC42 and Rac1, need to be activated, whereas RhoA must be inactivated. However, the cell and molecular mechanisms involved in optic nerve regeneration remain unclear...
January 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29028797/stat-wingless-and-nurf-38-determine-the-accuracy-of-regeneration-after-radiation-damage-in-drosophila
#6
Shilpi Verghese, Tin Tin Su
We report here a study of regeneration in Drosophila larval wing imaginal discs after damage by ionizing radiation. We detected faithful regeneration that restored a wing disc and abnormal regeneration that produced an extra wing disc. We describe a sequence of changes in cell number, location and fate that occur to produce an ectopic disc. We identified a group of cells that not only participate in ectopic disc formation but also recruit others to do so. STAT92E (Drosophila STAT3/5) and Nurf-38, which encodes a member of the Nucleosome Remodeling Factor complex, oppose each other in these cells to modulate the frequency of ectopic disc growth...
October 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28967390/the-negative-regulator-cxxc5-making-wnt-look-a-little-less%C3%A2-dishevelled
#7
Dongwon Kim, Luis A Garza
Wingless-related integration site (WNT)/β-catenin signaling regulates diverse physiological functions including tissue regeneration. Activation of WNT signaling can be inhibited by various agents. Lee et al. investigate the interaction of CXXC-type zinc finger protein 5 (CXXC5) with Dishevelled as one such negative regulator of WNT in hair follicle regeneration.
November 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28638086/wnt2b-attenuates-hscs-activation-and-liver-fibrosis-through-negative-regulating-tlr4-signaling
#8
Yi Yuan, Qiuju Han, Siyu Li, Zhigang Tian, Jian Zhang
The Wingless-type MMTV integration site family member 2b (Wnt2b) has been found to be a principal mediator of liver development and regeneration. However, the significance of Wnt2b in the pathogenesis of fibrosis-related liver diseases remains undefined. Here, we report that Wnt2b was highly expressed in the fibrotic liver tissues, exhibiting protective effects against activation of hepatic stellate cells (HSCs) and fibrosis progression. We identified a negative regulation of Wnt2b on the toll-like receptor 4 (TLR4) activation-mediated pro-fibrogenic effects...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28170184/regeneration-of-articular-cartilage-by-human-esc-derived-mesenchymal-progenitors-treated-sequentially-with-bmp-2-and-wnt5a
#9
Jason D Gibson, Michael B O'Sullivan, Farhang Alaee, David N Paglia, Ryu Yoshida, Rosa M Guzzo, Hicham Drissi
The success of cell-based therapies to restore joint cartilage requires an optimal source of reparative progenitor cells and tight control of their differentiation into a permanent cartilage phenotype. Bone morphogenetic protein 2 (BMP-2) has been extensively shown to promote mesenchymal cell differentiation into chondrocytes in vitro and in vivo. Conversely, developmental studies have demonstrated decreased chondrocyte maturation by Wingless-Type MMTV Integration Site Family, Member 5A (Wnt5a). Thus, we hypothesized that treatment of human embryonic stem cell (hESC)-derived chondroprogenitors with BMP-2 followed by Wnt5a may control the maturational progression of these cells into a hyaline-like chondrocyte phenotype...
January 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27589866/wnt-signaling-in-regulation-of-biological-functions-of-the-nurse-cell-harboring-trichinella-spp
#10
Magdalena Dabrowska, Marek Skoneczny, Zbigniew Zielinski, Wojciech Rode
BACKGROUND: The nurse cell (NC) constitutes in mammalian skeletal muscles a confined intracellular niche to support the metabolic needs of muscle larvae of Trichinella spp. encapsulating species. The main biological functions of NC were identified as hypermitogenic growth arrest and pro-inflammatory phenotype, both inferred to depend on AP-1 (activator protein 1) transcription factor. Since those functions, as well as AP-1 activity, are known to be regulated among other pathways, also by Wnt (Wingless-Type of Mouse Mammary Tumor Virus Integration Site) signaling, transcription profiling of molecules participating in Wnt signaling cascades in NC, was performed...
September 2, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27584613/drosophila-wnt-and-stat-define-apoptosis-resistant-epithelial-cells-for-tissue-regeneration-after-irradiation
#11
Shilpi Verghese, Tin Tin Su
Drosophila melanogaster larvae irradiated with doses of ionizing radiation (IR) that kill about half of the cells in larval imaginal discs still develop into viable adults. How surviving cells compensate for IR-induced cell death to produce organs of normal size and appearance remains an active area of investigation. We have identified a subpopulation of cells within the continuous epithelium of Drosophila larval wing discs that shows intrinsic resistance to IR- and drug-induced apoptosis. These cells reside in domains of high Wingless (Wg, Drosophila Wnt-1) and STAT92E (sole Drosophila signal transducer and activator of transcription [STAT] homolog) activity and would normally form the hinge in the adult fly...
September 2016: PLoS Biology
https://www.readbyqxmd.com/read/27542914/autophagy-independent-function-of-atg1-for-apoptosis-induced-compensatory-proliferation
#12
Mingli Li, Jillian L Lindblad, Ernesto Perez, Andreas Bergmann, Yun Fan
BACKGROUND: ATG1 belongs to the Uncoordinated-51-like kinase protein family. Members of this family are best characterized for roles in macroautophagy and neuronal development. Apoptosis-induced proliferation (AiP) is a caspase-directed and JNK-dependent process which is involved in tissue repair and regeneration after massive stress-induced apoptotic cell loss. Under certain conditions, AiP can cause tissue overgrowth with implications for cancer. RESULTS: Here, we show that Atg1 in Drosophila (dAtg1) has a previously unrecognized function for both regenerative and overgrowth-promoting AiP in eye and wing imaginal discs...
August 19, 2016: BMC Biology
https://www.readbyqxmd.com/read/27496569/regeneration-of-articular-cartilage-by-human-esc-derived-mesenchymal-progenitors-treated-sequentially-with-bmp-2-and-wnt5a
#13
Jason D Gibson, Michael B O'Sullivan, Farhang Alaee, David N Paglia, Ryu Yoshida, Rosa M Guzzo, Hicham Drissi
: The success of cell-based therapies to restore joint cartilage requires an optimal source of reparative progenitor cells and tight control of their differentiation into a permanent cartilage phenotype. Bone morphogenetic protein 2 (BMP-2) has been extensively shown to promote mesenchymal cell differentiation into chondrocytes in vitro and in vivo. Conversely, developmental studies have demonstrated decreased chondrocyte maturation by Wingless-Type MMTV Integration Site Family, Member 5A (Wnt5a). Thus, we hypothesized that treatment of human embryonic stem cell (hESC)-derived chondroprogenitors with BMP-2 followed by Wnt5a may control the maturational progression of these cells into a hyaline-like chondrocyte phenotype...
August 5, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27095093/alteration-of-canonical-and-non-canonical-wnt-signaling-by-crystalline-silica-in-human-lung-epithelial-cells
#14
Timothy N Perkins, Mieke A Dentener, Frank R Stassen, Gernot G Rohde, Brooke T Mossman, Emiel F M Wouters, Niki L Reynaert
Growth and development of the mature lung is a complex process orchestrated by a number of intricate developmental signaling pathways. Wingless-type MMTV-integration site (WNT) signaling plays critical roles in controlling branching morphogenesis cell differentiation, and formation of the conducting and respiratory airways. In addition, WNT pathways are often re-activated in mature lungs during repair and regeneration. WNT- signaling has been elucidated as a crucial contributor to the development of idiopathic pulmonary fibrosis as well as other hyper-proliferative lung diseases...
June 15, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/26893943/picking-a-bone-with-wisp1-ccn4-new-strategies-against-degenerative-joint-disease
#15
Kenneth Maiese
As the world's population continues to age, it is estimated that degenerative joint disease disorders such as osteoarthritis will impact at least 130 million individuals throughout the globe by the year 2050. Advanced age, obesity, genetics, gender, bone density, trauma, and a poor level of physical activity can lead to the onset and progression of osteoarthritis. However, factors that lead to degenerative joint disease and involve gender, genetics, epigenetic mechanisms, and advanced age are not within the control of an individual...
2016: Journal of Translational Science
https://www.readbyqxmd.com/read/26861315/wnt16-signaling-is-required-for-il-1%C3%AE-induced-matrix-metalloproteinase-13-regulated-proliferation-of-human-stem-cell-derived-osteoblastic-cells
#16
Nobuaki Ozeki, Makio Mogi, Naoko Hase, Taiki Hiyama, Hideyuki Yamaguchi, Rie Kawai, Ayami Kondo, Kazuhiko Nakata
We established a differentiation method for homogeneous α7 integrin-positive human skeletal muscle stem cell (α7⁺hSMSC)-derived osteoblast-like (α7⁺hSMSC-OB) cells, and found that interleukin (IL)-1β induces matrix metalloproteinase (MMP)-13-regulated proliferation of these cells. These data suggest that MMP-13 plays a potentially unique physiological role in the regeneration of osteoblast-like cells. Here, we examined whether up-regulation of MMP-13 activity by IL-1β was mediated by Wingless/int1 (Wnt) signaling and increased the proliferation of osteoblast-like cells...
February 6, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26840050/localized-epigenetic-silencing-of-a-damage-activated-wnt-enhancer-limits-regeneration-in-mature-drosophila-imaginal-discs
#17
Robin E Harris, Linda Setiawan, Josh Saul, Iswar K Hariharan
Many organisms lose the capacity to regenerate damaged tissues as they mature. Damaged Drosophila imaginal discs regenerate efficiently early in the third larval instar (L3) but progressively lose this ability. This correlates with reduced damage-responsive expression of multiple genes, including the WNT genes wingless (wg) and Wnt6. We demonstrate that damage-responsive expression of both genes requires a bipartite enhancer whose activity declines during L3. Within this enhancer, a damage-responsive module stays active throughout L3, while an adjacent silencing element nucleates increasing levels of epigenetic silencing restricted to this enhancer...
February 3, 2016: ELife
https://www.readbyqxmd.com/read/26777594/techniques-for-the-induction-of-human-pluripotent-stem-cell-differentiation-towards-cardiomyocytes
#18
REVIEW
Jarosław Lewandowski, Tomasz J Kolanowski, Maciej Kurpisz
The derivation of pluripotent stem cells from human embryos and the generation of induced pluripotent stem cells (iPSCs) from somatic cells opened a new chapter in studies on the regeneration of the post-infarction heart and regenerative medicine as a whole. Thus, protocols for obtaining iPSCs were enthusiastically adopted and widely used for further experiments on cardiac differentiation. iPSC-mediated cardiomyocytes (iPSC-CMs) under in vitro culture conditions are generated by simulating natural cardiomyogenesis and involve the wingless-type mouse mammary tumour virus integration site family (WNT), transforming growth factor beta (TGF-β) and fibroblast growth factor (FGF) signalling pathways...
May 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/26709793/regeneration-in-the-nervous-system-with-erythropoietin
#19
REVIEW
Kenneth Maiese
Globally, greater than 30 million individuals are afflicted with disorders of the nervous system accompanied by tens of thousands of new cases annually with limited, if any, treatment options. Erythropoietin (EPO) offers an exciting and novel therapeutic strategy to address both acute and chronic neurodegenerative disorders. EPO governs a number of critical protective and regenerative mechanisms that can impact apoptotic and autophagic programmed cell death pathways through protein kinase B (Akt), sirtuins, mammalian forkhead transcription factors, and wingless signaling...
January 1, 2016: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/26631481/mtor-disruption-causes-intestinal-epithelial-cell-defects-and-intestinal-atrophy-postinjury-in-mice
#20
Leesa L Sampson, Ashley K Davis, Matthew W Grogg, Yi Zheng
Intestinal stem cells (ISCs) drive small intestinal epithelial homeostasis and regeneration. Mechanistic target of rapamycin (mTOR) regulates stem and progenitor cell metabolism and is frequently dysregulated in human disease, but its physiologic functions in the mammalian small intestinal epithelium remain poorly defined. We disrupted the genes mTOR, Rptor, Rictor, or both Rptor and Rictor in mouse ISCs, progenitors, and differentiated intestinal epithelial cells (IECs) using Villin-Cre. Mutant tissues and wild-type or heterozygous littermate controls were analyzed by histologic immunostaining, immunoblots, and proliferation assays...
March 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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