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p63 and ck5/6 carcinomas

Andrew Wood, Fiona Young, James Morrison, Brendon I Conn
We present a case of sclerosing odontogenic carcinoma (SOC) occurring on the hard palate of a 43-year-old female. The tumor presented as an asymptomatic firm swelling and histopathologically was characterized by widely dispersed nests and cords of bland cells infiltrating between hyalinized collagen fibers. Prominent perineural and intraneural invasion and erosion of bone was noted. The tumor cells showed staining with antibodies to pan-cytokeratin (PanCK), cytokeratin 19 (CK19), cytokeratin 5/6 (CK5/6), cytokeratin 14 (CK14), p63 and E-cadherin, but no staining with antibodies to carcinoembryonic antigen (CEA), cytokeratin 7 (CK7), cytokeratin 20 (CK20), estrogen receptor (ER), progesterone receptor (PR) or S100...
July 25, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Y H Zhao, H G Liu
OBJECTIVE: To study the clinicopathologic features, immunophenotype, differential diagnosis and prognosis of non-keratinizing carcinoma of nasal cavity and paranasal sinus. METHODS: Four hundred and forty-one cases of squamous cell carcinoma of the nasal cavity and sinuses diagnosed in Beijing Tongren Hospital from January 2008 to August 2015 were included. Twenty-six cases of non-keratinizing carcinomas were selected. The histopathologic features and the clinicopathologic data of these twenty-six cases were retrospectively analyzed...
September 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Y Huang, C Y Wu, W Wu, L K Hou, L P Zhang
OBJECTIVE: To investigate the clinicopathological features and epidermal growth factor receptor (EGFR) gene mutation of primary pulmonary mucoepidermoid carcinoma (PMC). METHODS: Fifth-five cases of PMC were included in the study; their clinicopathological, immunohistochemical features were evaluated, and in 31 cases, paraffin embedded specimens were subjected to mutation analysis of exons 18, 19, 20 and 21 of the EGFR gene by ARMS method. RESULTS: There were 32 females and 23 males...
September 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Kei Kushitani, Vishwa Jeet Amatya, Yasuko Okada, Yuya Katayama, Amany Sayed Mawas, Yoshihiro Miyata, Morihito Okada, Kouki Inai, Takumi Kishimoto, Yukio Takeshima
AIMS: The aim of this study was to clarify the usefulness of immunohistochemistry in the differential diagnosis of epithelioid mesothelioma with solid growth pattern (solid epithelioid mesothelioma; SEM) and poorly differentiated squamous cell carcinoma (PDSCC), and to confirm a specific type of antibody panel. Additionally, we aimed to clarify the pitfalls of immunohistochemical analyses. METHODS AND RESULTS: Formalin-fixed paraffin-embedded specimens from 36 cases of SEM and 38 cases of PDSCC were immunohistochemically examined for calretinin, podoplanin (D2-40), Wilms' tumour gene product (WT1), cytokeratin (CK) 5/6, p40, p63, carcinoembryonic antigen (CEA), epithelial-related antigen (MOC31), claudin-4, thyroid transcription factor (TTF-1), and napsin A...
September 2, 2016: Histopathology
Frederick A Jakobiec, Anna M Stagner, Ralph C Eagle, Sara E Lally, Jeffrey F Krane
A 49-year-old woman with a past history of breast cancer slowly developed painless, lowgrade right proptosis with 20/25 visual acuity and 20/20 in the uninvolved left eye. Imaging studies disclosed an oval to round superotemporal mass in the right lacrimal fossa without bone erosion. Excisional biopsy revealed a pseudoencapsulated, bosselated tumor with a spindled, hypocellular and heavily PAS-positive stroma constituted by abundant basement membrane material and collagen. Scattered lumens and focal cribriform cellular clusters were present in the peripheries of several of the lobules...
August 24, 2016: Survey of Ophthalmology
Yang Chen, Hong Zhu, Feng Xu, Yidan Cao, Xingting Gu, Yuming Wan, Hongfeng Gou
We performed a retrospective analysis of 21 patients with primary gastric squamous cell carcinoma (PGSCC) who were admitted to our hospital from October 2008 to October 2014. The median age was 67 years and male predominance was observed, the most common tumor locations were the upper third of the stomach, most of the clinical manifestations were identical to those of other types of gastric tumors, and the tumor cells had positive immunoreactivity for p63 and CK5/6. In terms of treatments, surgery (R0 resection) is the main treatment; the effect of other treatments is unclear...
2016: Gastroenterology Research and Practice
Meghan E Kapp, Giovanna A Giannico, Mohamed Mokhtar Desouki
Cancer of the male breast is an uncommon event with metastases to the breast occurring even less frequently. Prostate carcinoma has been reported as the most frequent primary to metastasize to the breast; however, the reverse has not been previously reported. Herein, we present, for the first time, a case of breast carcinoma metastasizing to the prostate gland. Prostate needle core biopsy revealed infiltrative nests of neoplastic epithelioid cells, demonstrated by immunohistochemistry (IHC) to be positive for GATA3 and ER and negative for PSA and P501S...
2016: Case Reports in Oncological Medicine
Chunkai Yu, Zhigang Song, Zhibo Xiao, Qiushi Lin, Xiaoqun Dong
Mucoepidermoid carcinoma (MEC), an extremely rare tumor, arises from the epithelial component of preexisting parotid Warthin tumors (WT). Among the 309 cases of surgically resected WTs in Chinese PLA General Hospital and Beijing Shijitan Hospital of Capital Medical University, 5 cases (1.6%) fulfilled the criteria for MECs transformed from WTs. Clinicopathological characteristics of MECs was demonstrated in order to avoid misdiagnosis of this rare type of tumor. All the 5 patients, 3 males and 2 females, presented painless masses in the parotid gland...
2016: Scientific Reports
Kim HooKim, Catherine S Chaudoir, Shabnum I Chaudhery, Michelle D Reid
Therapy for non-small cell lung carcinoma (NSCLC) is currently determined by histologic subtype and the presence or absence of actionable mutations. Accurate subclassification is therefore essential for appropriate selection of cases for molecular studies and guiding treatment. The gold standard for subclassification of NSCLC is identification of differentiating morphologic features in correlation with diagnostic immunohistochemistry (IHC) in cases of poorly differentiated carcinoma. Whereas Napsin A, TTF1, and p40 antibodies have been used individually for the subtyping of NSCLC, few studies have examined the 3 in cocktail form...
June 2, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
Tokiko Nakai, Shu Ichihara, Akiko Kada, Noriko Ito, Suzuko Moritani, Tomonori Kawasaki, Tomoko Uchiyama, Hiroe Itami, Kouhei Morita, Masato Takano, Maiko Takeda, Kinta Hatakeyama, Chiho Ohbayashi
Adenoid cystic carcinoma (AdCC) of the breast is an uncommon but distinct neoplasm composed of a dual cell population polarized around true glandular (luminal) spaces and pseudolumina. The aim of this study was to clarify whether various immunohistochemical markers (CK7, EMA, CD117, p63, calponin, CD10, S100, CK5/6, CK14, vimentin, and type IV collagen) can distinguish between the two cell types in classical AdCC (n = 14) and in collagenous spherulosis (n = 5). The sensitivity and specificity of these 11 markers to distinguish luminal from abluminal cells were evaluated using a curve created by plotting the true-positive rate (sensitivity) against the false-positive rate (1 - specificity) at threshold settings of 0, 10, 50, and 70 %...
August 2016: Virchows Archiv: An International Journal of Pathology
Fei Du, Chuan-Xiang Zhou, Yan Gao
Adenoid cystic carcinoma (AdCC) is known as a biphasic tumor composed of ductal and myoepithelial cells. The present study aimed to evaluate the amount and distribution of the myoepithelial cells in cribriform, tubular and solid subtypes of AdCC and analyze their relationship with histological grading and prognosis. A panel of myoepithelial markers including CK5/6, p63, p40, D2-40, calponin, α-SMA, S-100, and vimentin, together with a luminal cell marker CK7, and Ki-67 were used for immunohistochemical study in 109 AdCCs that included 38 cribriform, 36 tubular and 35 solid subtypes...
June 2016: Annals of Diagnostic Pathology
Nong-Rong Wang, Meng-Meng Wang, Lv Zhou, Ze-Lin Liu, Nan-Ping Chen, Jin-Ping Hu, Yan-Juan Deng, Xiao-Qing Qi, Xiao-Feng Huang, Yue Su, Si-Yao Zhang, Fei Tong, Yu Zhang, Qi Lu, Zi-Yu Zhu, Huan Deng
BACKGROUND: The clear cell/signet-ring cell variant of cutaneous squamous cell carcinoma (cSCC) is extremely rare. Its carcinogenesis has consistently been linked to ultraviolet radiation and HPV in the literature. However, there is little definite information about the contribution of diabetes mellitus (DM) to cSCC. CASE PRESENTATION: A 78-year-old Chinese woman with type 2 DM presented with a mushroom-like lump in her right thigh. Histological findings revealed that the lesion was mainly composed of clear cells and signet-ring cells...
2016: Diagnostic Pathology
Shuangping Guo, Yingmei Wang, Joseph Rohr, Chaoliang Fan, Qinglong Li, Xia Li, Zhe Wang
INTRODUCTION: Solid papillary carcinoma of the breast, a newly-defined entity, is poorly recognized, and its nature and management is still debated. MATERIAL AND METHODS: Eleven cases of pure solid papillary breast carcinoma in our archive and 253 cases reported in previous literature were retrospectively analyzed for their clinicopathological features and outcomes. RESULTS: The eleven cases occurred in elderly females. Grossly, all tumors were well-circumscribed and typically composed of solid papillary nodules...
April 2016: Breast: Official Journal of the European Society of Mastology
Zhichao Lin, Dongrong Situ, Xiangzhen Chang, Wenhua Liang, Meiling Zhao, Chengjie Cai, Yang Liu, Jianxing He
OBJECTIVES: Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare but unique subtype of non-small-cell lung cancer (NSCLC). Our study aimed to evaluate clinicopathological characteristics and the value of surgical treatment for LELC and explore the relevant prognostic factors in a relatively large cohort. METHODS: We retrospectively reviewed the medical records of 39 lung LELC patients who underwent pulmonary resection with curative intent between January 2009 and December 2013...
July 2016: Interactive Cardiovascular and Thoracic Surgery
Weijie Zhao, Yoon-La Choi, Ji-Young Song, Yazhen Zhu, Qing Xu, Feng Zhang, Lili Jiang, Ju Cheng, Guangjuan Zheng, Mao Mao
OBJECTIVES: Chromosomal rearrangements of ALK and ROS1 genes in non-small cell lung carcinoma (NSCLC) define a molecular subgroup of lung adenocarcinoma (ADC) that is amenable to targeted therapy with tyrosine kinase inhibitors (TKIs) crizotinib. Emerging clinical studies have demonstrated that patients with RET-rearranged NSCLC may also benefit from existing RET TKIs, including cabozantinib and vandetanib. However, the reported cases of lung squamous cell carcinomas (SCC) harboring gene rearrangements have been detected via fluorescence in situ hybridization (FISH) or immunohistochemistry (IHC) from materials such as biopsy or resection...
April 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Catherine M Nguyen, Kim Chong, David Cassarino
Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only 13 cases reported to date. The differential diagnoses often include dermal neoplasms composed of clear cells, such as squamous cell carcinoma, basal cell carcinoma, metastatic renal cell carcinoma and balloon cell malignant melanoma...
June 2016: Journal of Cutaneous Pathology
J K Chambers, Y Yoshino, R Fujiwara, R Nishimura, H Nakayama, K Uchida
An 11-year-old female Chihuahua exhibited respiratory distress and a computed tomography scan showed a large mass in the anterior thoracic cavity. During surgery, it was found that the mass was strongly adherent to surrounding tissue. A histopathological examination of a biopsy sample from the mass revealed proliferation of atypical epithelial cells and cartilage formation admixed with mature lymphocytes. Immunohistochemically, the tumour cells, as well as the normal canine thymic epithelial cells, were positive for pan-cytokeratin (CK), CK5/6, CK19, p63 and bone morphogenetic protein (BMP) 6...
January 2016: Journal of Comparative Pathology
Liang Wang, Yongbin Lin, Qingqing Cai, Hao Long, Yu Zhang, Tiehua Rong, Guowei Ma, Ying Liang
BACKGROUND: Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a distinct rare subtype of lung cancer. The prevalence of anaplastic lymphoma kinase (ALK) rearrangement and epidermal growth factor receptor (EGFR) mutation in primary pulmonary LELC had not been thoroughly investigated. METHODS: We investigated a cohort of 42 patients with primary pulmonary LELC and genotyped for ALK rearrangement and EGFR mutation. ALK rearrangement was detected by fluorescence in situ hybridization (FISH)...
September 2015: Journal of Thoracic Disease
Mutahir A Tunio, Mushabbab AlAsiri, Khalid Riaz, Reham Abdulmoniem
Metastatic involvement of the optic nerve or its sheath is very rare (1.3 - 3%). The most common malignancies reported to metastasize to the optic nerve or its sheath are breast, lung, kidney, bladder, gastric and colorectal cancers. Carcinoma of uterine cervix metastatic to optic nerve and optic nerve sheath is extremely rare and is associated with grave prognosis due to underlying high tumor burden. Here in, we report a 61-year Saudi woman who was treated with concurrent chemoradiation for squamous cell carcinoma of cervix FIGO IVA 6 months back...
September 2015: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Shogo Tajima, Ichiro Namiki, Kenji Koda
The predominance of clear cells in mucoepidermoid carcinomas (MEC) is rare, and cases in which this occurs are termed clear cell variants of MEC. We present a case of a 70-year-old woman complaining of a right buccal mucosal mass, which had increased in size over 1 year. Histological examination revealed the mass to be composed predominantly of clear tumor cells, with mucin-containing cells and intermediate cell-like cells. Immunohistochemistry indicated that the tumor was positive for CK5/6 and p63, but negative for myoepithelial markers such as S-100 protein, αSMA, and calponin...
August 22, 2015: Medical Molecular Morphology
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