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p63 and ck5/6 carcinomas

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https://www.readbyqxmd.com/read/28121221/the-association-between-circulating-tumor-cells-and-epstein-barr-virus-activation-in-patients-with-nasopharyngeal-carcinoma
#1
Caiyun He, Xinjun Huang, Xuan Su, Tao Tang, Xiao Zhang, Jiangjun Ma, Xiang Guo, Xing Lv
BACKGROUND: Circulating tumor cells (CTCs) and microemboli (CTM) are attracting increasing attention in medical biology and clinical practice. However, the clinical relevance of CTCs in nasopharyngeal carcinoma (NPC) has not yet been ascertained, and no study has focused on the influence of Epstein-Barr virus (EBV) status on CTCs in NPC patients. These issues were therefore examined. METHODS: Peripheral blood samples were prospectively obtained from 33 NPC patients before treatment...
January 25, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28112486/pleural-fluid-cytology-samples-in-cases-of-suspected-lung-cancer-an-experience-from-a-tertiary-care-centre
#2
Gurwinder Kaur, Raje Nijhawan, Nalini Gupta, Navneet Singh, Arvind Rajwanshi
OBJECTIVE: Pleural effusion is present in some patients with lung carcinoma. This study was undertaken to evaluate the role of pleural fluid cytology in suspected cases of lung carcinoma. METHODS: In this prospective study, 86 cases of suspected primary lung carcinoma associated with pleural effusion were included. Cytomorphology of conventional smears was combined with LBC smears and a cytomorphological diagnosis was offered. An immunopanel of CK7, CK5/6, p63, TTF1, calretinin, and CD56 was applied on cell blocks...
January 23, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28099906/genomic-characteristics-of-pancreatic-squamous-cell-carcinoma-an-investigation-by-using-high-throughput-sequencing-after-in-solution-hybrid-capture
#3
Meng-Dan Xu, Shu-Ling Liu, Yi-Zhong Feng, Qiang Liu, Meng Shen, Qiaoming Zhi, Zeyi Liu, Dong-Mei Gu, Jie Yu, Liu-Mei Shou, Fei-Ran Gong, Qi Zhu, Weiming Duan, Kai Chen, Junning Zhang, Meng-Yao Wu, Min Tao, Wei Li
Squamous cell carcinoma (SCC) of pancreas is a rare histotype of pancreatic ductal carcinoma which is distinct from pancreatic adenocarcinoma (AC). Although there are standard treatments for pancreatic AC, no precise therapies exist for pancreatic SCC. Here, we screened 1033 cases of pancreatic cancer and identified 2 cases of pure SCC, which were pathologically diagnosed on the basis of finding definite intercellular bridges and/or focal keratin peal formation in the tumor cells. Immunohistochemistry assay confirmed the positive expression of CK5/6 and p63 in pancreatic SCC...
January 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28072972/-clinicopathologic-features-of-adenoid-cystic-carcinoma-of-breast
#4
S P Guo, Q L Li, Y M Wang, K X Zeng, Y Liu, W N Xu, X M Zhang
Objective: To investigate the clinicopathologic features and grading of adenoid cystic carcinoma (ACC) of the breast. Methods: Sixteen cases of ACC of the breast were analyzed and graded according to the previous report. Immunohistochemical (IHC) staining was used to detect the immunophenotype, Ki-67 proliferative index and expression of EZH2, and the association with tumor grade and outcome was analyzed. Results: Of the 16 cases, 11 were grade Ⅰ, with the epithelial and myoepithelial cells being arranged into tubular and cribriform structure with no solid component; three were grade Ⅱ, which were composed of mixed tubular, cribriform and solid component (<30%); and two were grade Ⅲ, which showed mainly solid component (>90%) and the tumor cells showed basaloid features with scanty cytoplasm and hyperchromatic nuclei, and mitotic count was>5/10 HPF...
January 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28069272/smarcb1-ini1-deficient-sinonasal-carcinoma-shows-methylation-of-rassf1-gene-a-clinicopathological-immunohistochemical-and-molecular-genetic-study-of-a-recently-described-entity
#5
Jan Laco, Marcela Chmelařová, Hana Vošmiková, Kateřina Sieglová, Ivana Bubancová, Pavel Dundr, Kristýna Němejcová, Jaroslav Michálek, Petr Čelakovský, Radovan Mottl, Igor Sirák, Milan Vošmik, Aleš Ryška
The aim of the study was detailed clinicopathological investigation of SMARCB1/INI1-deficient sinonasal carcinomas, including molecular genetic analysis of mutational status and DNA methylation of selected protooncogenes and tumor suppressor genes by means of next generation sequencing (NGS) and methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA). A total of 4/56 (7%) cases of SMARCB1/INI1-deficient carcinomas were detected among 56 sinonasal carcinomas diagnosed over a 19year period using immunohistochemical screening...
October 25, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28029685/immunoprofile-of-metaplastic-carcinomas-of-the-breast
#6
Emad A Rakha, Nuno D M Coimbra, Zsolt Hodi, Enaam Juneinah, Ian O Ellis, Andrew H S Lee
BACKGROUND: Metaplastic breast carcinoma (MBC) is a rare type of breast cancer and its diagnosis in routine practice can be challenging and may require immunohistochemical (IHC) characterisation if no conventional invasive or in situ carcinoma is present. Previous IHC studies of MBC often had a small sample size and did not investigate the different histological subtypes. This study aimed to assess the immunoprofile of MBC subtypes in a large series. METHODS: 172 MBC diagnosed in routine and referral practice in Nottingham over 26 years were reviewed by 3 breast pathologists...
December 28, 2016: Histopathology
https://www.readbyqxmd.com/read/28000303/primary-cutaneous-histiocytoid-carcinoma-with-distant-metastasis
#7
Rebecca Philips, Leila Langston, Helena Hwang, Travis Vandergriff, Tanya Trynosky, Alma C Berlingeri-Ramos
Distinguishing primary cutaneous adnexal carcinoma from metastatic carcinoma of unknown primary can be a diagnostic challenge due to the frequent overlap of histologic and immunohistochemical features. A 58-year-old man presented with a tender, indurated plaque on axillary skin. Biopsy revealed infiltrating atypical cells throughout the dermis, without connection to the epidermis. Tumor cells had a histiocytoid appearance and displayed mild pleomorphism. The tumor was discohesive and had areas with a single file pattern...
December 21, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27889037/pathology-of-anal-cancer
#8
REVIEW
Paulo M Hoff, Renata Coudry, Camila Motta Venchiarutti Moniz
Anal canal cancer is rather an uncommon disease but its incidence is increasing. Squamous cell carcinoma (SCC) is the most frequent primary anal neoplasm and can encompass a variety of morphologies. HPV infection has a key role in precancerous lesions and cancer development by the production of E6 and E7 oncoproteins. Anal squamous precancerous lesions are now classified according to the same criteria and terminology as their cervical counterparts. The p16 expression by immunohistochemistry is a surrogate marker for human papilloma virus (HPV)...
January 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/27743835/sclerosing-odontogenic-carcinoma-presenting-on-the-hard-palate-of-a-43-year-old-female-a-case-report
#9
Andrew Wood, Fiona Young, James Morrison, Brendon I Conn
We present a case of sclerosing odontogenic carcinoma (SOC) occurring on the hard palate of a 43-year-old female. The tumor presented as an asymptomatic firm swelling and histopathologically was characterized by widely dispersed nests and cords of bland cells infiltrating between hyalinized collagen fibers. Prominent perineural and intraneural invasion and erosion of bone was noted. The tumor cells showed staining with antibodies to pan-cytokeratin (PanCK), cytokeratin 19 (CK19), cytokeratin 5/6 (CK5/6), cytokeratin 14 (CK14), p63 and E-cadherin, but no staining with antibodies to carcinoembryonic antigen (CEA), cytokeratin 7 (CK7), cytokeratin 20 (CK20), estrogen receptor (ER), progesterone receptor (PR) or S100...
December 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27646894/-clinicopathologic-features-of-non-keratinizing-carcinoma-of-nasal-cavity-and-paranasal-sinus
#10
Y H Zhao, H G Liu
OBJECTIVE: To study the clinicopathologic features, immunophenotype, differential diagnosis and prognosis of non-keratinizing carcinoma of nasal cavity and paranasal sinus. METHODS: Four hundred and forty-one cases of squamous cell carcinoma of the nasal cavity and sinuses diagnosed in Beijing Tongren Hospital from January 2008 to August 2015 were included. Twenty-six cases of non-keratinizing carcinomas were selected. The histopathologic features and the clinicopathologic data of these twenty-six cases were retrospectively analyzed...
September 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27646889/-clinicopathologic-features-and-epidermal-growth-factor-receptor-gene-mutation-of-primary-pulmonary-mucoepidermoid-carcinoma
#11
Y Huang, C Y Wu, W Wu, L K Hou, L P Zhang
OBJECTIVE: To investigate the clinicopathological features and epidermal growth factor receptor (EGFR) gene mutation of primary pulmonary mucoepidermoid carcinoma (PMC). METHODS: Fifth-five cases of PMC were included in the study; their clinicopathological, immunohistochemical features were evaluated, and in 31 cases, paraffin embedded specimens were subjected to mutation analysis of exons 18, 19, 20 and 21 of the EGFR gene by ARMS method. RESULTS: There were 32 females and 23 males...
September 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27589012/utility-and-pitfalls-of-immunohistochemistry-in-the-differential-diagnosis-between-epithelioid-mesothelioma-and-poorly-differentiated-lung-squamous-cell-carcinoma
#12
Kei Kushitani, Vishwa J Amatya, Yasuko Okada, Yuya Katayama, Amany S Mawas, Yoshihiro Miyata, Morihito Okada, Kouki Inai, Takumi Kishimoto, Yukio Takeshima
AIMS: The aims of this study were to clarify the usefulness of immunohistochemistry in the differential diagnosis of epithelioid mesothelioma with a solid growth pattern [solid epithelioid mesothelioma (SEM)] and poorly differentiated squamous cell carcinoma (PDSCC), and to confirm the validity of a specific type of antibody panel. Additionally, we aimed to clarify the pitfalls of immunohistochemical analyses. METHODS AND RESULTS: Formalin-fixed paraffin-embedded specimens from 36 cases of SEM and 38 cases of PDSCC were immunohistochemically examined for calretinin, podoplanin (D2-40), Wilms' tumour gene product (WT1), cytokeratin (CK) 5/6, p40, p63, carcinoembryonic antigen (CEA), epithelial-related antigen (MOC31), claudin-4, thyroid transcription factor-1 (TTF-1), and napsin A...
February 2017: Histopathology
https://www.readbyqxmd.com/read/27567603/unusual-pleomorphic-adenoma-of-the-lacrimal-gland-immunohistochemical-demonstration-of-plag1-and-hmga2-oncoproteins
#13
Frederick A Jakobiec, Anna M Stagner, Ralph C Eagle, Sara E Lally, Jeffrey F Krane
A 49-year-old woman with a past history of breast cancer slowly developed painless, lowgrade right proptosis with 20/25 visual acuity and 20/20 in the uninvolved left eye. Imaging studies disclosed an oval to round superotemporal mass in the right lacrimal fossa without bone erosion. Excisional biopsy revealed a pseudoencapsulated, bosselated tumor with a spindled, hypocellular and heavily PAS-positive stroma constituted by abundant basement membrane material and collagen. Scattered lumens and focal cribriform cellular clusters were present in the peripheries of several of the lobules...
August 24, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27478431/clinicopathological-characteristics-treatment-and-prognosis-of-21-patients-with-primary-gastric-squamous-cell-carcinoma
#14
Yang Chen, Hong Zhu, Feng Xu, Yidan Cao, Xingting Gu, Yuming Wan, Hongfeng Gou
We performed a retrospective analysis of 21 patients with primary gastric squamous cell carcinoma (PGSCC) who were admitted to our hospital from October 2008 to October 2014. The median age was 67 years and male predominance was observed, the most common tumor locations were the upper third of the stomach, most of the clinical manifestations were identical to those of other types of gastric tumors, and the tumor cells had positive immunoreactivity for p63 and CK5/6. In terms of treatments, surgery (R0 resection) is the main treatment; the effect of other treatments is unclear...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27429817/metastatic-breast-carcinoma-to-the-prostate-gland
#15
Meghan E Kapp, Giovanna A Giannico, Mohamed Mokhtar Desouki
Cancer of the male breast is an uncommon event with metastases to the breast occurring even less frequently. Prostate carcinoma has been reported as the most frequent primary to metastasize to the breast; however, the reverse has not been previously reported. Herein, we present, for the first time, a case of breast carcinoma metastasizing to the prostate gland. Prostate needle core biopsy revealed infiltrative nests of neoplastic epithelioid cells, demonstrated by immunohistochemistry (IHC) to be positive for GATA3 and ER and negative for PSA and P501S...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27417276/mucoepidermoid-carcinoma-arising-in-warthin-s-tumor-of-the-parotid-gland-clinicopathological-characteristics-and-immunophenotypes
#16
Chunkai Yu, Zhigang Song, Zhibo Xiao, Qiushi Lin, Xiaoqun Dong
Mucoepidermoid carcinoma (MEC), an extremely rare tumor, arises from the epithelial component of preexisting parotid Warthin tumors (WT). Among the 309 cases of surgically resected WTs in Chinese PLA General Hospital and Beijing Shijitan Hospital of Capital Medical University, 5 cases (1.6%) fulfilled the criteria for MECs transformed from WTs. Clinicopathological characteristics of MECs was demonstrated in order to avoid misdiagnosis of this rare type of tumor. All the 5 patients, 3 males and 2 females, presented painless masses in the parotid gland...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27258567/the-use-of-a-novel-immunohistochemical-triple-cocktail-in-the-subclassification-of-resected-non-small-cell-lung-carcinomas-a-comparative-study-with-morphology-and-traditional-immunohistochemistry
#17
Kim HooKim, Catherine S Chaudoir, Shabnum I Chaudhery, Michelle D Reid
Therapy for non-small cell lung carcinoma (NSCLC) is currently determined by histologic subtype and the presence or absence of actionable mutations. Accurate subclassification is therefore essential for appropriate selection of cases for molecular studies and guiding treatment. The gold standard for subclassification of NSCLC is identification of differentiating morphologic features in correlation with diagnostic immunohistochemistry (IHC) in cases of poorly differentiated carcinoma. Whereas Napsin A, TTF1, and p40 antibodies have been used individually for the subtyping of NSCLC, few studies have examined the 3 in cocktail form...
June 2, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27240462/the-unique-luminal-staining-pattern-of-cytokeratin-5-6-in-adenoid-cystic-carcinoma-of-the-breast-may-aid-in-differentiating-it-from-its-mimickers
#18
Tokiko Nakai, Shu Ichihara, Akiko Kada, Noriko Ito, Suzuko Moritani, Tomonori Kawasaki, Tomoko Uchiyama, Hiroe Itami, Kouhei Morita, Masato Takano, Maiko Takeda, Kinta Hatakeyama, Chiho Ohbayashi
Adenoid cystic carcinoma (AdCC) of the breast is an uncommon but distinct neoplasm composed of a dual cell population polarized around true glandular (luminal) spaces and pseudolumina. The aim of this study was to clarify whether various immunohistochemical markers (CK7, EMA, CD117, p63, calponin, CD10, S100, CK5/6, CK14, vimentin, and type IV collagen) can distinguish between the two cell types in classical AdCC (n = 14) and in collagenous spherulosis (n = 5). The sensitivity and specificity of these 11 markers to distinguish luminal from abluminal cells were evaluated using a curve created by plotting the true-positive rate (sensitivity) against the false-positive rate (1 - specificity) at threshold settings of 0, 10, 50, and 70 %...
August 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27180054/myoepithelial-differentiation-in-cribriform-tubular-and-solid-pattern-of-adenoid-cystic-carcinoma-a-potential-involvement-in-histological-grading-and-prognosis
#19
Fei Du, Chuan-Xiang Zhou, Yan Gao
Adenoid cystic carcinoma (AdCC) is known as a biphasic tumor composed of ductal and myoepithelial cells. The present study aimed to evaluate the amount and distribution of the myoepithelial cells in cribriform, tubular and solid subtypes of AdCC and analyze their relationship with histological grading and prognosis. A panel of myoepithelial markers including CK5/6, p63, p40, D2-40, calponin, α-SMA, S-100, and vimentin, together with a luminal cell marker CK7, and Ki-67 were used for immunohistochemical study in 109 AdCCs that included 38 cribriform, 36 tubular and 35 solid subtypes...
June 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27066782/cutaneous-clear-cell-signet-ring-cell-squamous-cell-carcinoma-arising-in-the-right-thigh-of-a-patient-with-type-2-diabetes-combined-morphologic-immunohistochemical-and-etiologic-analysis
#20
Nong-Rong Wang, Meng-Meng Wang, Lv Zhou, Ze-Lin Liu, Nan-Ping Chen, Jin-Ping Hu, Yan-Juan Deng, Xiao-Qing Qi, Xiao-Feng Huang, Yue Su, Si-Yao Zhang, Fei Tong, Yu Zhang, Qi Lu, Zi-Yu Zhu, Huan Deng
BACKGROUND: The clear cell/signet-ring cell variant of cutaneous squamous cell carcinoma (cSCC) is extremely rare. Its carcinogenesis has consistently been linked to ultraviolet radiation and HPV in the literature. However, there is little definite information about the contribution of diabetes mellitus (DM) to cSCC. CASE PRESENTATION: A 78-year-old Chinese woman with type 2 DM presented with a mushroom-like lump in her right thigh. Histological findings revealed that the lesion was mainly composed of clear cells and signet-ring cells...
April 11, 2016: Diagnostic Pathology
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