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https://www.readbyqxmd.com/read/29223598/prognosis-and-treatment-of-positive-peritoneal-cytology-in-early-endometrial-cancer-matched-cohort-analyses-from-the-national-cancer-database
#1
Brandon-Luke L Seagle, Amy L Alexander, Taliya Lantsman, Shohreh Shahabi
BACKGROUND: While positive peritoneal cytology is no longer included among the endometrial cancer staging criteria, FIGO recommends continued collection of pelvic washings for cytology in order to produce additional data that may be used to determine the significance of positive cytology for prognosis and treatment of endometrial cancer. OBJECTIVES: To validate that positive cytology is a predictor of decreased survival in early endometrial cancer and to test if adjuvant chemotherapy for positive cytology is associated with increased survival...
December 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29210800/molecular-modifiers-of-hormone-receptor-action-decreased-androgen-receptor-expression-in-mismatch-repair-deficient-endometrial-endometrioid-adenocarcinoma
#2
Qiong Gan, Suzanne Crumley, Russell R Broaddus
Endometrial endometrioid carcinoma is related to estrogen excess and expression of estrogen and progesterone receptors. Epidemiological evidence suggests that exposure to elevated androgens, as in polycystic ovarian syndrome, increases the risk of endometrial cancer. Factors impacting androgen receptor (AR) expression are not well studied. Mismatch repair (MMR) deficiency due to MLH1 gene methylation is one of the most common molecular alterations in endometrial cancer, occurring in 15% to 20% of cases. MLH1 methylation can be associated with decreased expression of other genes, so we examined the effect of MMR status on AR expression...
November 28, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29208958/the-positivity-of-estrogen-receptor-and-progesterone-receptor-may-not-be-associated-with-metastasis-and-recurrence-in-epithelial-ovarian-cancer
#3
Shouzhen Chen, Xujing Dai, Yifei Gao, Fang Shen, Jingxin Ding, Qi Chen
The estrogen (ER) or progesterone receptors (PR) is positively associated with better clinical outcomes in ovarian cancer. Whether metastasis or recurrence of ovarian cancer is correlated with this association has not been investigated. Data on 894 women with epithelial ovarian cancer were collected and the association between ER or PR positivity and peritoneal or lymph node metastases or recurrence was analysed. ER or PR positivity was higher in high-grade, low-grade serous and endometrioid carcinoma, but lower in mucinous and clear-cell carcinoma...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208367/the-role-of-epcam-in-tumor-progression-and-the-clinical-prognosis-of-endometrial-carcinoma
#4
Kuo-Chang Wen, Pi-Lin Sung, Yu-Ting Chou, Chih-Ming Pan, Peng-Hui Wang, Oscar Kuang-Sheng Lee, Cheng-Wen Wu
OBJECTIVE: EpCAM is a transmembrane glycoprotein that functions as an epithelial marker in endometrial tissues. However, the correlation between EpCAM and endometrial carcinoma (EC) is not clear. METHODS: This study investigated the association between EpCAM and EC. Immunohistochemistry staining and bioinformatics analysis disclosed the clinical importance of low EpCAM expression. The migratory ability of cells expressing low EpCAM levels was studied in transwell invasion assays in vitro and an orthotopic intra-uterine tumor injection model in vivo...
December 2, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29200893/epidemiology-of-ovarian-cancers-in-zaria-northern-nigeria-a-10-year-study
#5
Marliyya Sanusi Zayyan, Saad Aliyu Ahmed, Adekunle O Oguntayo, Abimbola O Kolawole, Tajudeen Ayodeji Olasinde
Background: Globally, the absence of a premalignant stage of ovarian cancer and a reliable screening tool make early diagnosis difficult. Locally, poverty, ignorance, and lack of organized cancer services make prognosis poor. We describe the epidemiological features of ovarian cancer seen at Ahmadu Bello University Teaching Hospital Zaria, Northern Nigeria, a tertiary referral center, over a 10-year period in this challenging setting. Methods: All cases of histologically diagnosed ovarian cancer between January 1, 2004 and December 31, 2013 were included in the study...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29198879/radiation-therapy-improves-disease-specific-survival-in-women-with-stage-ii-endometrioid-endometrial-cancer-brachytherapy-may-be-sufficient
#6
Chika R Nwachukwu, Rie Von-Eyben, Elizabeth A Kidd
PURPOSE: To evaluate disease-specific survival (DSS) outcomes in Stage II endometrioid endometrial cancer (EC) patients based on pathology and treatment information including adjuvant radiotherapy and lymph node assessment. METHODS AND MATERIALS: Using the Surveillance, Epidemiology, and End Results database, 2877 patients with Stage II EC diagnosed between 2004 and 2012 treated with radiation were identified. DSS was determined for different modalities of radiation...
November 30, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29195926/clinicopathologic-characteristics-associated-with-long-term-survival-in-advanced-epithelial-ovarian-cancer-an-nrg-oncology-gynecologic-oncology-group-ancillary-data-study
#7
C A Hamilton, A Miller, Y Casablanca, N S Horowitz, B Rungruang, T C Krivak, S D Richard, N Rodriguez, M J Birrer, F J Backes, M A Geller, M Quinn, M J Goodheart, D G Mutch, J J Kavanagh, G L Maxwell, M A Bookman
OBJECTIVE: To identify clinicopathologic factors associated with 10-year overall survival in epithelial ovarian cancer (EOC) and primary peritoneal cancer (PPC), and to develop a predictive model identifying long-term survivors. METHODS: Demographic, surgical, and clinicopathologic data were abstracted from GOG 182 records. The association between clinical variables and long-term survival (LTS) (>10years) was assessed using multivariable regression analysis. Bootstrap methods were used to develop predictive models from known prognostic clinical factors and predictive accuracy was quantified using optimism-adjusted area under the receiver operating characteristic curve (AUC)...
November 28, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29194195/gene-expression-signature-based-prediction-of-lymph-node-metastasis-in-patients-with-endometrioid-endometrial-cancer
#8
Sokbom Kang, Zachary Thompson, E Claire McClung, Reem Abdallah, Jae K Lee, Jesus Gonzalez-Bosquet, Robert M Wenham, Hye Sook Chon
OBJECTIVE: This study aimed to develop a prediction model for lymph node metastasis using a gene expression signature in patients with endometrioid-type endometrial cancer. METHODS: Newly diagnosed endometrioid-type endometrial cancer cases in which the patients had undergone lymphadenectomy during a surgical staging procedure were identified from a national dataset (N = 330). Clinical and pathologic data were extracted from patient medical records, and gene expression datasets of their tumors were used to create a 12-gene predictive model for lymph node metastasis...
November 30, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29192745/impact-of-coexistent-adenomyosis-on-outcomes-of-patients-with-endometrioid-endometrial-cancer-a-propensity-score-matched-analysis
#9
Hulya Ayik Aydin, Tayfun Toptas, Selen Bozkurt, Elif Pestereli, Tayup Simsek
PURPOSE: Despite the common occurrence of adenomyosis in endometrial cancer (EC), there is a paucity and conflict in the literature regarding its impact on outcomes of patients. We sought to compare outcomes of patients with endometrioid type EC with or without adenomyosis. METHODS: A total of 314 patients were included in the analysis. Patients were divided into 2 groups according to the presence or absence of adenomyosis. Adenomyosis was identified in 79 patients (25...
November 30, 2017: Tumori
https://www.readbyqxmd.com/read/29190668/dual-expression-of-immunoreactive-estrogen-receptor-%C3%AE-and-p53-is-a-potential-predictor-of-regional-lymph-node-metastasis-and-postoperative-recurrence-in-endometrial-endometrioid-carcinoma
#10
Takeshi Obata, Mitsuhiro Nakamura, Yasunari Mizumoto, Takashi Iizuka, Masanori Ono, Jumpei Terakawa, Takiko Daikoku, Hiroshi Fujiwara
Although histological grade and muscular invasion are related to the malignant behaviors of endometrial endometrioid carcinoma, lymphatic and/or distant metastases are unexpectedly encountered, even in patients in the low-risk group. To re-evaluate additional reliable parameters to predict the risk of progression, we examined the immunohistochemical expression profiles of p53 and estrogen receptor (ER) β proteins. Patients with endometrial endometrioid carcinoma who underwent surgical treatment at our hospital (n = 154) were recruited to this study, and the significance of the relationships between the incidence of regional lymph node metastasis and/or postoperative recurrence and clinical or experimental parameters was evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/29189263/b7-h4-is-inversely-correlated-with-t-cell-infiltration-in-clear-cell-but-not-serous-or-endometrioid-ovarian-cancer
#11
Gabriel M Pagnotti, Richard M Atkinson, Jamie Romeiser, Ali Akalin, Mallory B Korman, Kenneth R Shroyer
B7-H4, a tumor-associated cell surface protein, is expressed in endometrioid (EM), serous (SE), and clear cell (CC) ovarian carcinomas. Prior in vitro studies from other groups indicated that elevated B7-H4 expression by tumor cells blocks T-cell activation; therefore, it had been postulated to play a role in shielding cancer cells from immune surveillance and averting apoptotic programs. To test the validity of these hypotheses, the present study was designed to compare the immunohistochemical staining intensity of B7-H4 in tumor cells of ovarian cancers with the number of tumor-infiltrating T cells and macrophages and with the levels of caspase-3 staining in apoptotic debris...
October 20, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29188658/assessing-local-stromal-alterations-in-human-ovarian-cancer-subtypes-via-second-harmonic-generation-microscopy-and-analysis
#12
Kirby R Campbell, Paul J Campagnola
The collagen architecture in all human ovarian cancers is substantially remodeled, where these alterations are manifested in different fiber widths, fiber patterns, and fibril size and packing. Second harmonic generation (SHG) microscopy has differentiated normal tissues from high-grade serous (HGS) tumors with high accuracy; however, the classification between low-grade serous, endometrioid, and benign tumors was less successful. We postulate this is due to known higher genetic variation in these tissues relative to HGS tumors, which are genetically similar, and this results in more heterogeneous collagen remodeling in the respective matrix...
November 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29187928/hormone-receptor-expression-status-of-epithelial-ovarian-cancer-in-ibadan-south-western-nigeria
#13
Mustapha Akanji Ajani, Ayodeji Salami, Olutosin Alaba Awolude, Abideen Olayiwola Oluwasola
Introduction: Epidemiological evidence strongly suggests that steroid hormones are implicated in the pathogenesis of ovarian cancer. Estrogen receptor (ER) and Progesterone receptor (PR) are prognostic indicators for a number of epithelial tumors and may play the same role in ovarian cancers. This study aims to evaluate the expression of ER and PR in epithelial ovarian cancer (EOC) in an African population and compare it with other prognostic factors such as age, International Federation of Gynaecology and Obstetrics (FIGO) stage, grade and histological subtype...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29185259/role-of-lymphadenectomy-in-intermediate-risk-endometrial-cancer-a-matched-pair-study
#14
Pluvio J Coronado, Agnieszka Rychlik, Maria A Martínez-Maestre, Laura Baquedano, María Fasero, Aida García-Arreza, Sara Morales, Daniel M Lubian, Ignacio Zapardiel
OBJECTIVE: To assess the impact of lymph node dissection (LND) on morbidity, survival, and cost for intermediate-risk endometrial cancers (IREC). METHODS: A multicenter retrospective cohort of 720 women with IREC (endometrioid histology with myometrial invasion <50% and grade 3; or myometrial invasion ≥50% and grades 1-2; or cervical involvement and grades 1-2) was carried out. All patients underwent hysterectomy and bilateral salpingo-oophorectomy. A matched pair analysis identified 178 pairs (178 with LND and 178 without it) equal in age, body mass index, co-morbidities, American Society of Anesthesiologist score, myometrial invasion, and surgical approach...
January 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29178260/origin-of-clear-cell-carcinoma-nature-or-nurture
#15
David L Kolin, Daniela M Dinulescu, Christopher P Crum
A rare but serious complication of endometriosis is the development of carcinoma, and clear cell and endometrioid carcinomas of the ovary are the two most common malignancies which arise from endometriosis. They are distinct diseases, characterized by unique morphologies, immunohistochemical profiles, and responses to treatment. However, both arise in endometriosis and can share common mutations. The overlapping mutational profiles of clear cell and endometrioid carcinoma suggests that their varied histologies may be due to a different cell of origin which gives rise to each type of cancer...
November 27, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29174935/the-impact-of-adjuvant-vaginal-brachytherapy-in-women-with-stage-ii-uterine-endometrioid-carcinoma-results-of-a-national-cancer-database-analysis
#16
Joon K Lee, Ahmed I Ghanem, Ankit Modh, Charlotte Burmeister, Omar Mahmoud, G Larry Maxwell, Mohamed A Elshaikh
PURPOSE: To report survival outcomes in women with Stage II uterine endometrioid carcinoma who received adjuvant radiation therapy (RT) without chemotherapy using the National Cancer Database. METHODS AND MATERIALS: The National Cancer Database was queried for women with International Federation of Gynecology and Obstetrics Stage II uterine endometrioid carcinoma who underwent hysterectomy followed by adjuvant RT without chemotherapy. The χ2 tests were performed to compare differences in outcome by type of adjuvant RT (external beam radiation therapy [EBRT] alone, vaginal brachytherapy [VBT] alone, or combination of EBRT and VBT)...
November 23, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29174567/the-unrecognized-burden-of-cardiovascular-risk-factors-in-women-newly-diagnosed-with-endometrial-cancer-a-prospective-case-control-study
#17
Sarah J Kitson, Jennifer Lindsay, Vanitha N Sivalingam, Mark Lunt, Neil A J Ryan, Richard J Edmondson, Martin K Rutter, Emma J Crosbie
BACKGROUND: Cardiovascular disease is a major cause of death in endometrial cancer survivors. The aim of this study was to determine whether women newly diagnosed with endometrial cancer have a higher prevalence of cardiovascular risk factors than the general population. METHODS: The prevalence of adequately treated and unrecognized/inadequately treated cardiovascular risk factors and the corresponding 10-year cardiovascular risk by QRISK2 score was measured in 150 consecutive women undergoing primary treatment for endometrioid endometrial cancer in the North West of England, and 746 age and ethnicity-matched control women from the Health Survey for England 2014...
November 24, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29172287/polycystic-ovarian-morphology-may-be-a-positive-prognostic-factor-in-patients-with-endometrial-cancer-who-achieved-complete-remission-after-fertility-sparing-therapy-with-progestin
#18
Yamato Fukui, Ayumi Taguchi, Katsuyuki Adachi, Marie Sato, Akira Kawata, Michihiro Tanikawa, Kenbun Sone, Mayuyo Mori, Kazunori Nagasaka, Yoko Matsumoto, Takahide Arimoto, Katsutoshi Oda, Yutaka Osuga, Tomoyuki Fujii
Background: The most studied fertility-sparing therapy for endometrial cancer (EC) is oral progestin therapy. However, complete remission (CR) rate after progestin therapy is not enough ranging from 60 to 80 %, with high recurrence rate. Clinical features that predict treatment efficacy and recurrence after progestin therapy have not yet been revealed in detail. The aim of this study was to investigate prognostic factors in patients with EC who achieved CR after medroxyprogesterone acetate (MPA) therapy. Methods: We retrospectively reviewed 35 EC patients treated with MPA at our institution between 2000 and 2016...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29162652/elucidating-the-pathogenesis-of-synchronous-and-metachronous-tumors-in-a-woman-with-endometrioid-carcinomas-using-a-whole-exome-sequencing-approach
#19
Ren-Chin Wu, Ema Veras, Jeffrey Lin, Emily Gerry, Asli Bahadirli-Talbott, Alexander Baras, Ayse Ayhan, Ie-Ming Shih, Tian-Li Wang
Synchronous endometrial and ovarian (SEO) carcinomas involve endometrioid neoplasms in both the ovary and uterus at the time of diagnosis. Patients were traditionally classified as having independent primary SEO lesions or as having metastatic endometrioid carcinoma. Recent studies have supported that SEO tumors result from the dissemination of cells from one organ site to another. However, whether this can be considered a "metastasis" or "dissemination" remains unclear. In this report, we performed whole-exome sequencing of tumor samples from a woman with well-differentiated endometrioid SEO tumors and a clinical "recurrent" poorly differentiated peritoneal tumor that was diagnosed 8 years after the complete resection of the SEO tumors...
November 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29155953/max-mutations-in-endometrial-cancer-clinicopathologic-associations-and-recurrent-max-p-his28arg-functional-characterization
#20
Christopher J Walker, Craig M Rush, Paola Dama, Matthew J O'Hern, Casey M Cosgrove, Jessica L Gillespie, Roman A Zingarelli, Blair Smith, Maggie E Stein, David G Mutch, Reena Shakya, Chia-Wen Chang, Karuppaiyah Selvendiran, Jonathan W Song, David E Cohn, Paul J Goodfellow
Background: Genomic studies have revealed that multiple genes are mutated at varying frequency in endometrial cancer (EC); however, the relevance of many of these mutations is poorly understood. An EC-specific recurrent mutation in the MAX transcription factor p.His28Arg was recently discovered. We sought to assess the functional consequences of this hotspot mutation and determine its association with cancer-relevant phenotypes. Methods: MAX was sequenced in 509 endometrioid ECs, and associations between mutation status and clinicopathologic features were assessed...
November 15, 2017: Journal of the National Cancer Institute
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