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https://www.readbyqxmd.com/read/28724271/comparison-of-histopathologic-features-of-endometrial-cancer-based-on-menopausal-status-and-safety-of-ovarian-preservation-in-premenopausal-women
#1
Ozgur Kan, Aysegul Alkilic, Elif Nazlı Cetindag Aydın, Kazibe Koyuncu, Salih Taskin, Firat Ortac
The aim of this study was to investigate the frequency of coexisting ovarian malignancy and to determine whether ovarian preservation is feasible in premenopausal endometrial cancer (EC) patients. The data of 251 patients with endometrioid type endometrial cancer were retrospectively reviewed. We classified patients into two groups based on menopausal status. Information regarding patient age, preoperative and intraoperative evaluations, pathology reports, and follow-up results were abstracted from medical records...
May 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28721180/adenomyosis-back-to-the-future
#2
Z Ferraz, N Nogueira-Martins, F Nogueira-Martins
Adenomyosis is a benign invasion of endometrium into the myometrium. It produces a diffusely enlarged uterus and predominantly affects women in the late reproductive age. It has recently been associated with a negative impact on female fertility. Diagnosis is challenging because nonspecific symptoms can be present. However, it is asymptomatic in the majority of women. Medical treatment with GnRH agonist seems to be promising, particularly in subfertile women. A retrospective study was performed (182 patients) by examination of histopathological results with "adenomyosis" between January/2013 and September/2016...
March 2017: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28718916/the-genetic-landscape-of-endometrial-clear-cell-carcinomas
#3
Deborah F DeLair, Kathleen A Burke, Pier Selenica, Raymond S Lim, Sasinya N Scott, Sumit Middha, Abhinita S Mohanty, Donavan T Cheng, Michael F Berger, Robert A Soslow, Britta Weigelt
Clear cell carcinoma of the endometrium is a rare type of endometrial cancer generally associated with an aggressive clinical behavior. Here we sought to define the repertoire of somatic genetic alterations in endometrial clear cell carcinomas (ECCs) and whether ECCs could be classified into the molecular subtypes described for endometrial endometrioid and serous carcinomas. We performed a rigorous histopathological review, immunohistochemical analysis and massively parallel sequencing targeting 300 cancer-related genes of 32 pure ECCs...
July 18, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28718377/downregulation-of-tyrosine-threonine-kinase-inhibits-tumor-growth-via-g2-m-arrest-in-human-endometrioid-endometrial-adenocarcinoma
#4
Jiamiao Zhang, Yan Jiang, Yu Zhao, Wanxue Wang, Yiran Xie, Huating Wang, Yihua Yang
Endometrial cancer is the most common gynecologic malignancy, about 80% of which is endometrial endometrioid carcinoma. Dysregulation of spindle assembly checkpoint plays a vital role in endometrial endometrioid carcinoma tumorigenesis and progression. The purpose of this study was to explore how tyrosine threonine kinase, a spindle assembly checkpoint-related protein, promotes the endometrial endometrioid carcinoma progression. We found that both messenger RNA and protein levels of tyrosine threonine kinase in endometrial endometrioid carcinoma tissues are higher than those in normal endometrial tissues, and its expression is associated with tumor stages...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28716603/the-role-of-complete-staging-surgery-for-pure-endometrioid-type-endometrial-cancer
#5
EDITORIAL
Yiu-Tai Li, Huann-Cheng Horng, Peng-Hui Wang
No abstract text is available yet for this article.
July 14, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28712776/clonal-evolution-in-paired-endometrial-intraepithelial-neoplasia-atypical-hyperplasia-and-endometrioid-adenocarcinoma
#6
Mariano Russo, James Broach, Kathryn Sheldon, Kenneth R Houser, Dajiang J Liu, Joshua Kesterson, Rebecca Phaeton, Carrie Hossler, Nadine Hempel, Maria Baker, Jordan M Newell, Richard Zaino, Joshua I Warrick
Endometrial intraepithelial neoplasia (EIN) and atypical endometrial hyperplasia (AH) are histomorphologically-defined precursors to endometrioid adenocarcinoma, which are unified as EIN/AH by the World Health Organization. EIN/AH harbors a constellation of molecular alterations similar those found in endometrioid adenocarcinoma. However, the process of clonal evolution from EIN/AH to carcinoma is poorly characterized. To investigate, we performed next generation sequencing, copy number alteration (CNA) analysis, and immunohistochemistry for mismatch repair protein expression on EIN/AH and endometrioid adenocarcinoma samples from 6 hysterectomy cases with spatially distinct EIN/AH and carcinoma...
July 13, 2017: Human Pathology
https://www.readbyqxmd.com/read/28711930/primary-endometrioid-stromal-sarcomas-of-the-ovary-a-clinicopathological-study-of-14-cases-with-a-review-of-the-literature
#7
Weimin Xie, Xiaoning Bi, Dongyan Cao, Jiaxin Yang, Keng Shen, Yan You
PURPOSE: Primary endometrioid stromal sarcomas (ESS) of the ovary are rare mesenchymal tumors with scarce data on their behavior and optimal treatment. We aimed to describe the clinicopathologic features and outcome among patients with primary ovarian ESS. RESULTS: The age of the patients ranged from 34 to 61 years (mean: 49.1 years, median: 51.5 years). The most common symptoms were abdominal distention or pain or both. Nine (64.3%) and five patients (35.7%) had low-grade and high-grade disease, respectively...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28709704/epigenetic-silencing-of-mlh1-in-endometrial-cancers-is-associated-with-larger-tumor-volume-increased-rate-of-lymph-node-positivity-and-reduced-recurrence-free-survival
#8
Casey M Cosgrove, David E Cohn, Heather Hampel, Wendy L Frankel, Dan Jones, Joseph P McElroy, Adrian A Suarez, Weiqiang Zhao, Wei Chen, Ritu Salani, Larry J Copeland, David M O'Malley, Jeffrey M Fowler, Ahmet Yilmaz, Alexis S Chassen, Rachel Pearlman, Paul J Goodfellow, Floor J Backes
OBJECTIVES: To determine the relationship between mismatch repair (MMR) classification and clinicopathologic features including tumor volume, and explore outcomes by MMR class in a contemporary cohort. METHODS: Single institution cohort evaluating MMR classification for endometrial cancers (EC). MMR immunohistochemistry (IHC)±microsatellite instability (MSI) testing and reflex MLH1 methylation testing was performed. Tumors with MMR abnormalities by IHC or MSI and MLH1 methylation were classified as epigenetic MMR deficiency while those without MLH1 methylation were classified as probable MMR mutations...
July 11, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28709703/extent-of-lymphovascular-space-invasion-may-predict-lymph-node-metastasis-in-uterine-serous-carcinoma
#9
Yushen Qian, Erqi L Pollom, Chika Nwachukwu, Kira Seiger, Rie von Eyben, Ann K Folkins, Elizabeth A Kidd
OBJECTIVES: Emerging evidence suggests that extent of lymphovascular space invasion (LVSI) predicts for risk of lymph node metastasis in endometrioid uterine cancers. However, this correlation remains unknown in the setting of uterine serous carcinoma (USC). We sought to examine the association between extent of LVSI and other histopathologic characteristics with risk of nodal metastasis for women with USC. MATERIALS/METHODS: Pathological data from all cases of uterine serous carcinoma between July 1998 to July 2015 at our institution were reviewed...
July 11, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28709581/trends-in-end-of-life-care-and-healthcare-spending-in-women-with-uterine-cancer
#10
Benjamin Margolis, Ling Chen, Melissa K Accordino, Grace Clarke Hillyer, June Y Hou, Ana I Tergas, William M Burke, Alfred I Neugut, Cande V Ananth, Dawn L Hershman, Jason D Wright
BACKGROUND: High intensity care including hospitalizations, chemotherapy and other interventions at the end of life is costly and often of little value for cancer patients. Little is known about patterns of end of life care and resource utilization for women with uterine cancer. OBJECTIVE: We examined the costs and predictors of aggressive end of life care for women with uterine cancer. METHODS: In this observational cohort study the Surveillance, Epidemiology and End Results-Medicare linked database was used to identify women >65 who died from uterine cancer from 2000-2011...
July 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28708275/frequency-of-endometrial-cancer-and-atypical-hyperplasia-in-infertile-women-undergoing-hysteroscopic-polypectomy
#11
Yasushi Kuribayashi, Koji Nakagawa, Rie Sugiyama, Hiroshi Motoyama, Rikikazu Sugiyama
AIM: We aimed to determine the frequency of endometrial cancer in infertile women undergoing hysteroscopic endometrial polypectomy for endometrial polyps. METHODS: A total of 1035 infertile patients who underwent office-based hysteroscopic polypectomy at Sugiyama Clinic Marunouchi between July 2011 and October 2015 were eligible for this retrospective study. All patients had been diagnosed with endometrial polyps via hysterofiberscopy prior to operation, and they underwent hysteroscopic endometrial polypectomy using a resectoscope with monopolar resection...
July 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28704325/clinical-utility-of-preoperative-computed-tomography-in-patients-with-endometrial-cancer
#12
Giorgio Bogani, Bobbie S Gostout, Sean C Dowdy, Francesco Multinu, Jvan Casarin, William A Cliby, Luigi Frigerio, Bohyun Kim, Amy L Weaver, Gretchen E Glaser, Andrea Mariani
OBJECTIVE: The aim of this study was to determine the clinical utility of routine preoperative pelvic and abdominal computed tomography (CT) examinations in patients with endometrial cancer (EC). METHODS: We retrospectively reviewed records from patients with EC who underwent a preoperative endometrial biopsy and had surgery at our institution from January 1999 through December 2008. In the subset with an abdominal CT scan obtained within 3 months before surgery, we evaluated the clinical utility of the CT scan...
July 12, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28700436/malignant-female-adnexal-tumor-of-probable-wolffian-origin-case-report-and-literature-review
#13
Shuhui Hong, Jing Cui, Li Li, Joseph Buscema, Casandra Liggins, Wenxin Zheng
Although most female adnexal tumors of probable Wolffian origin have a benign biologic behavior, occasional cases have exhibited malignant potential. We encountered a 50-yr-old woman with an uncommon female adnexal tumors of probable Wolffian origin, which involved bilateral ovaries, invaded the ipsilateral fallopian tube, and extended to the uterine serosa. The initial histopathologic presentation caused significant confusion in pathologic diagnosis. Multiple differential diagnoses including ovarian endometrioid carcinoma, Sertoli cell tumor, and metastasis from nongynecologic organs were considered...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28700425/ultrastaging-of-sentinel-lymph-nodes-in-endometrial-carcinoma-according-to-use-of-2-different-methods
#14
Elizabeth Euscher, Dawen Sui, Pamela Soliman, Shannon Westin, Preetha Ramalingam, Roland Bassett, Anais Malpica
Sentinel lymph node (SLN) sampling may provide staging information without exposing patients to risks of lymph node dissection. There is no consensus protocol for optimal pathologic handling of these specimens. This study compares 2 ultrastaging protocols of SLN in endometrial carcinoma (EC). All SLN were serially sectioned perpendicular to the long axis in 2 mm intervals and entirely submitted for routine hematoxylin and eosin (H&E) processing. SLN negative by routine processing had ultrastaging (US) by one of the following: method 1 (M1), 5 H&E levels at 250 μm intervals with 2 unstained slides at each level; pankeratin immunohistochemistry (IHC) performed on level 1 in cases with negative H&E levels or method 2 (M2), 1 H&E level + 2 unstained slides cut 250 μm into the tissue block; pankeratin IHC performed in cases with negative H&E...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28697110/risk-of-subsequent-ovarian-cancer-after-ovarian-conservation-in-young-women-with-stage-i-endometrioid-endometrial-cancer
#15
Koji Matsuo, Hiroko Machida, Rebecca L Stone, Pamela T Soliman, Premal H Thaker, Lynda D Roman, Jason D Wright
OBJECTIVE: To examine the cumulative incidence of subsequent ovarian cancer among young women with stage I endometrioid endometrial cancer who had ovarian conservation at surgical treatment. METHODS: This retrospective study examined the Surveillance, Epidemiology, and End Results Program to identify women aged younger than 50 years who underwent hysterectomy with ovarian conservation for stage I endometrioid endometrial cancer between 1983 and 2013. Time-dependent risk of ovarian cancer diagnosed during the follow-up after endometrial cancer diagnosis was examined...
July 7, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28696169/can-the-apparent-diffusion-coefficient-differentiate-the-grade-of-endometrioid-adenocarcinoma-and-the-histological-subtype-of-endometrial-cancer
#16
Bin Yan, Tingting Zhao, Xiufen Liang, Chen Niu, Caixia Ding
Background Diffusion-weighted imaging (DWI) provides useful information for the identification of benign and malignant uterine lesions. However, the use of the apparent diffusion coefficient (ADC) for histopathological grading of endometrial cancer is controversial. Purpose To explore the use of ADC values in differentiating the preoperative tumor grading of endometrioid adenocarcinomas and investigate the relationship between the ADC values of endometrial cancer and the histological tumor subtype. Material and Methods We retrospectively evaluated 98 patients with endometrial cancers, including both endometrioid adenocarcinomas (n = 80) and non-endometrioid adenocarcinomas (n = 18)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28695811/clinicopathological-features-analysis-of-86-endometrial-endometrioid-adenocarcinoma-patients-with-adnexal-involvement
#17
Jing Zuo, Min Cheng, Yan Song, Zhuo Li, Rong Zhang, Bin Li, Lingying Wu
To investigate the clinicopathological features of endometrial endometrioid adenocarcinoma(EEA)with adnexal involvement.Methods The clinicopathological data of 86 EEA patients who underwent surgical treatment at our center from January 2000 to December 2015 were analyzed retrospectively.The clinicopathological features were compared between patients with occult adnexal involvement and those with gross adnexal involvement.Results A total of 86 EEA patients with adnexal involvement(mean age:58.1 years)were included in this study,accounting for 5...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28678427/clear-cell-and-endometrioid-carcinomas-are-their-differences-attributable-to-distinct-cells-of-origin
#18
Dawn R Cochrane, Basile Tessier-Cloutier, Katherine M Lawrence, Tayyebeh Nazeran, Anthony N Karnezis, Clara Salamanca, Angela S Cheng, Jessica N McAlpine, Lien N Hoang, C Blake Gilks, David G Huntsman
Endometrial epithelium is the presumed tissue of origin for both eutopic and endometriosis-derived clear cell and endometrioid carcinomas. We had previously hypothesized that the morphological, biological and clinical differences between these carcinomas are due to histotype-specific mutations. Although some mutations and genomic landscape features are more likely to be found in one of these histotypes, we were not able to identify a single class of mutations that was exclusively present in one histotype and not the other...
July 5, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28673864/analysis-of-endometrial-carcinoma-in-young-women-at-a-high-volume-cancer-center
#19
Alper Biler, Ulas Solmaz, Selcuk Erkilinc, Mehmet Gokcu, Mustafa Bagci, Orhan Temel, Tugba Karadeniz, Muzaffer Sanci
OBJECTIVE: To investigate the clinicopathological characteristics, treatment, survival, and prognosis of endometrial cancer in women aged ≤40 years. METHODS: Women who underwent surgery for endometrial cancer at a single high-volume cancer center between January 1995 and December 2014 were retrospectively reviewed. Women aged >40, patients with missing data, and those who did not undergo surgical staging were excluded. Univariate and multivariate regression models were used to identify the risk factors for overall survival and progression-free survival...
June 30, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28669579/lessons-learnt-from-implementation-of-a-lynch-syndrome-screening-program-for-patients-with-gynaecological-malignancy
#20
Fedaa Najdawi, Ashley Crook, Jayne Maidens, Christopher McEvoy, Andrew Fellowes, Justine Pickett, Musei Ho, David Nevell, Kirsten McIlroy, Amy Sheen, Loretta Sioson, Mahsa Ahadi, John Turchini, Adele Clarkson, Russell Hogg, Sue Valmadre, Greg Gard, Susan J Dooley, Rodney J Scott, Stephen B Fox, Michael Field, Anthony J Gill
Despite a trend towards universal testing, best practice to screen patients presenting with gynaecological malignancy for Lynch syndrome (LS) is uncertain. We report our institutional experience of a co-ordinated gynaecological LS screening program. All patients with endometrial carcinoma or carcinosarcoma, or gynaecological endometrioid or clear cell carcinomas undergo reflex four panel immunohistochemistry (IHC) for MLH1, PMS2, MSH2 and MSH6 followed by cascade somatic hypermethylation analysis of the MLH1 promoter locus for dual MLH1/PMS2 negative tumours...
June 29, 2017: Pathology
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