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https://www.readbyqxmd.com/read/29673664/high-throughput-silencing-identifies-novel-genes-in-endometrioid-endometrial-cancer
#1
Afiqah Alyaa Md Fuzi, Siti Zawiah Omar, Zahurin Mohamed, Noor Azmi Mat Adenan, Norfilza Mohd Mokhtar
OBJECTIVE: To validate the gene expression profile obtained from the previous microarray analysis and to further study the biological functions of these genes in endometrial cancer. From our previous study, we identified 621 differentially expressed genes in laser-captured microdissected endometrioid endometrial cancer as compared to normal endometrial cells. Among these genes, 146 were significantly up-regulated in endometrial cancer. MATERIALS AND METHODS: A total of 20 genes were selected from the list of up-regulated genes for the validation assay...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673382/risk-of-synchronous-endometrial-disorders-in-women-with-endometrioid-borderline-tumors-of-the-ovary
#2
Shuang-Zheng Jia, Jun-Ji Zhang, Jun-Jun Yang, Yang Xiang, Zhiyong Liang, Jin-Hua Leng
BACKGROUND: Synchronous endometrial disorders have been poorly studied in women with endometrioid borderline ovarian tumors (EBOT). The aims of this study were to investigate the risk of endometrial disorders among women with EBOT and associated factors, as well as their oncological and fertility outcomes. RESULTS: This retrospective study included 33 women with EBOT. Their mean age was 41.9 years, and endometria were evaluated in 25 of these patients. The prevalence of synchronous endometrial disorders was 52...
April 19, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29671892/frequent-loss-of-claudin-4-expression-in-dedifferentiated-and-undifferentiated-endometrial-carcinomas
#3
Basile Tessier-Cloutier, Robert A Soslow, Colin J R Stewart, Martin Köbel, Cheng-Han Lee
INTRO: Dedifferentiated/undifferentiated endometrial carcinomas (DDEC/UEC) are aggressive endometrial cancers with frequent genomic inactivation of core components of switch/sucrose non-fermentable (SWI/SNF) complex proteins. Claudin-4, an epithelial intercellular tight junction protein was recently found to be expressed in SWI/SNF-deficient undifferentiated carcinomas but not SWI/SNF-deficient sarcomas. The aim of this study is to examine claudin-4 expression in UEC/DDEC and other high-grade uterine carcinomas...
April 19, 2018: Histopathology
https://www.readbyqxmd.com/read/29666643/rna-seq-reveals-the-overexpression-of-igsf9-in-endometrial-cancer
#4
Zonggao Shi, Chunyan Li, Laura Tarwater, Jun Li, Yang Li, William Kaliney, Darshan S Chandrashekar, M Sharon Stack
We performed RNA-seq on an Illumina platform for 7 patients with endometrioid endometrial carcinoma for which both tumor tissue and adjacent noncancer tissue were available. A total of 66 genes were differentially expressed with significance level at adjusted p value < 0.01. Using the gene functional classification tool in the NIH DAVID bioinformatics resource, 5 genes were found to be the only enriched group out of that list of genes. The gene IGSF9 was chosen for further characterization with immunohistochemical staining of a larger cohort of human endometrioid carcinoma tissues...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29664841/three-year-recurrence-free-survival-in-patients-with-a-very-low-risk-of-endometrial-cancer-who-did-not-undergo-lymph-node-dissection-tree-retro-a-korean-multicenter-study
#5
Miseon Kim, ChelHun Choi, Kidong Kim, Myong Cheol Lim, Jeong-Yeol Park, Jin Hwa Hong, Maria Lee, Jiheum Paek, Jungyeob Seoung, Seungho Lee, Taek Sang Lee
OBJECTIVE: Randomized studies have not demonstrated a survival benefit of routine lymph node dissection in early-stage endometrial cancer. Many surgeons nevertheless perform lymph node dissection in all patients with early-stage endometrial cancer. This study aimed to ascertain the survival outcomes of very low-risk endometrial cancer patients (by the Korean Gynecologic Oncology Group [KGOG] criteria) who did not undergo lymph node dissection. MATERIALS AND METHODS: Medical records of 156 consecutive patients who underwent surgical staging without lymph node dissection were collected from 10 institutions...
April 16, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29662718/is-the-measurement-of-the-size-of-uterine-lesions-with-positron-emission-tomography-consistent-in-pre-and-postmenopausal-periods-in-endometrioid-type-endometrial-cancer
#6
Varol Gülseren, Mustafa Kocaer, Özgü Çelikkol Güngördük, İsa Aykut Özdemir, Muzaffer Sancı, Kemal Güngördük
Objective: We aimed to investigate the correlation of the size and volume of uterine tumors obtained using positron emission tomography/computed tomography (PET/CT) and pathology specimens in patients with endometrioid-type endometrial cancer (EEC) in the premenopausal period, and to compare the results with those of postmenopausal women. In the premenopausal period, the endometrium uses more glucose than in the postmenopausal period. Therefore, the measurement of uterine tumor size using PET/CT in the premenopausal period may normally be different...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29662565/follicular-lymphoma-mimicking-metastatic-nodes-on-the-f-18-fdg-pet-ct-and-mri-for-staging-of-endometrial-cancer
#7
Seok-Nam Yoon
A 53-year-old woman was diagnosed with endometrial carcinoma by vaginal bleeding. F-18 fluorodeoxy glucose positron emission tomography PET/CT (F-18 FDG PET/CT) scan for staging showed intense focal FDG uptake in the endometrium suggesting endometrial malignancy. PET/CT showed multiple node uptakes in the pericaval region, paraaortic region, common iliac, and both internal iliac and external iliac regions suggesting multiple pelvic and retroperitoneal node metastases. MRI showed multiple metastatic lymphadenopathy in the retroperitoneum and pelvic cavity...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29659191/optimised-arid1a-immunohistochemistry-is-an-accurate-predictor-of-arid1a-mutational-status-in-gynaecological-cancers
#8
Saira Khalique, Kalnisha Naidoo, Ayoma D Attygalle, Divya Kriplani, Frances Daley, Anne Lowe, James Campbell, Thomas Jones, Michael Hubank, Kerry Fenwick, Nicholas Matthews, Alistair G Rust, Christopher J Lord, Susana Banerjee, Rachael Natrajan
ARID1A is a tumour suppressor gene that is frequently mutated in clear cell and endometrioid carcinomas of the ovary and endometrium and is an important clinical biomarker for novel treatment approaches for patients with ARID1A defects. However, the accuracy of ARID1A immunohistochemistry (IHC) as a surrogate for mutation status has not fully been established for patient stratification in clinical trials. Here we tested whether ARID1A immunohistochemistry could reliably predict ARID1A mutations identified by next-generation sequencing...
April 16, 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29656794/immunohistochemistry-for-mismatch-repair-protein-deficiency-in-endometrioid-endometrial-carcinoma-yields-equivalent-results-when-performed-on-endometrial-biopsy-curettage-or-hysterectomy-specimens
#9
David B Chapel, S Diane Yamada, Matthew Cowan, Ricardo R Lastra
OBJECTIVE: Universal screening of endometrial cancer (EC) for Lynch syndrome (LS) has been increasingly implemented in the past five to ten years. Most pathologists initiate screening with immunohistochemistry (IHC) for mismatch repair proteins (MMRPs), using either pre-surgical samplings (endometrial biopsy or curettage, EMB/C) or hysterectomy specimens. We report a systematic assessment of the equivalence of IHC for LS screening on EMB/C versus hysterectomy specimens. METHODS: We identified 99 patients diagnosed with endometrioid EC and performed IHC for MMRPs MLH1, MSH2, MSH6, and PMS2 on their diagnostic EMB/C and paired hysterectomy specimen...
April 13, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29642629/17%C3%AE-hydroxysteroid-dehydrogenase-type-2-expression-is-induced-by-androgen-signaling-in-endometrial-cancer
#10
Chiaki Hashimoto, Yasuhiro Miki, Sota Tanaka, Kiyoshi Takagi, Misaki Fue, Zhulanqiqige Doe, Bin Li, Nobuo Yaegashi, Takashi Suzuki, Kiyoshi Ito
Endometrial cancer is one of the most common female pelvic cancers and has been considered an androgen-related malignancy. Several studies have demonstrated the anti-cell proliferative effect of androgen on endometrial cancer cells; however, the mechanisms of the anti-cancer effect of androgen remain largely unclear. 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2), which catalyzes the conversion of E2 to E1, is known to be upregulated by androgen treatment in breast cancer cells. In this study, we therefore focused on the role of androgen on estrogen dependence in endometrial cancer...
April 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29626374/cleaved-caspase-3-expression-is-a-potential-prognostic-factor-for-endometrial-cancer-with-positive-peritoneal-cytology
#11
Naoki Ogane, Masanori Yasuda, Hisamori Kato, Tomomi Kato, Mitsutake Yano, Yoichi Kameda, Shingo Kamoshida
OBJECTIVE: Positive peritoneal cytology (PPC) in endometrial cancer remains a controversial topic. Cleaved caspase-3 (CC3) and Ki-67 are excellent markers of apoptotic and proliferating cells, respectively. The objective of this study was to determine the significance of CC3 and Ki-67 expression in peritoneal cytology samples as prognostic factors for endometrial cancer with PPC. METHODS: Sixty endometrial cancer specimens with PPC alone were divided into 51 endometrioid tumours (43 endometrioid carcinomas and 8 carcinomas with squamous differentiation) and 9 non-endometrioid tumours (2 serous carcinomas, 3 clear cell carcinomas, and 4 carcinosarcomas)...
April 6, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29621128/can-teamwork-and-high-volume-experience-overcome-challenges-of-lymphadenectomy-in-morbidly-obese-patients-body-mass-index-of-40-kg-m2-or-greater-with-endometrial-cancer-a-cohort-study-of-robotics-and-laparotomy-and-review-of-literature
#12
Hubert Fornalik, Temeka Zore, Nicole Fornalik, Todd Foster, Adrian Katschke, Gary Wright
OBJECTIVE: This study aimed to compare surgical outcomes and the adequacy of surgical staging in morbidly obese women with a body mass index (BMI) of 40 kg/m or greater who underwent robotic surgery or laparotomy for the staging of endometrioid-type endometrial cancer. METHODS: This is a retrospective cohort study of patients who underwent surgical staging between May 2011 and June 2014. Patients' demographics, surgical outcomes, intraoperative and postoperative complications, and pathological outcomes were compared...
April 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29620584/endometrial-carcinoma-with-an-unusual-morphology-in-a-patient-with-cornelia-de-lange-syndrome-a-case-study
#13
Keisei Tate, Hiroshi Yoshida, Mitsuya Ishikawa, Hanako Shimizu, Takashi Uehara, Tomoyasu Kato
Cornelia de Lange syndrome (CdLS) is a cohesinopathy, which is characterized by multiple structural anomalies as well as mental and growth retardation. A 36-yr-old nulliparous woman with oligomenorrhea was referred to us due to a mass in the uterine corpus. She had been clinically diagnosed with CdLS during infancy based on her specific facial features as well as growth and intellectual retardation. Imaging examinations and an endometrial biopsy revealed endometrial endometrioid carcinoma and polycystic ovary syndrome (PCOS)...
April 3, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29615163/diagnostic-accuracy-of-pelvic-mri-for-determination-of-the-cervical-involvement-in-endometrial-cancer
#14
Imrana Masroor, Sadia Rashid, Shaista Afzal, Saira Naz Sufian, Muhammad Azeemuddin
OBJECTIVE: To determine the diagnostic accuracy of pelvic MRI for assessment of the cervical involvement in endometrial cancer. STUDY DESIGN: Cross-sectional analytical study. PLACE AND DURATION OF STUDY: Radiology Department of the Aga Khan University Hospital, Karachi from January 2014 to December 2015. METHODOLOGY: Patients with biopsy-proven endometrial cancer were included, who had both their MRI and histopathological diagnosis performed at our institution...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29605499/significance-of-abnormal-peritoneal-cytology-on-survival-of-women-with-stage-i-ii-endometrioid-endometrial-cancer
#15
Koji Matsuo, Akira Yabuno, Marianne S Hom, Masako Shida, Mamoru Kakuda, Sosuke Adachi, Rachel S Mandelbaum, Yutaka Ueda, Kosei Hasegawa, Takayuki Enomoto, Mikio Mikami, Lynda D Roman
OBJECTIVE: To examine survival of women with stage I-II endometrioid endometrial cancer whose peritoneal cytology showed malignant or atypical cells (abnormal peritoneal cytology). METHODS: This is a multi-center retrospective study examining 1668 women with stage I-II endometrioid endometrial cancer who underwent primary hysterectomy with available peritoneal cytology results between 2000 and 2015. Abnormal peritoneal cytology was correlated to clinico-pathological characteristics and oncological outcome...
March 12, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29605044/racial-disparities-in-molecular-subtypes-of-endometrial-cancer
#16
Elizabeth A Dubil, Chunqiao Tian, Guisong Wang, Christopher M Tarney, Nicholas W Bateman, Douglas A Levine, Thomas P Conrads, Chad A Hamilton, George Larry Maxwell, Kathleen M Darcy
OBJECTIVES: Racial differences in the molecular subtypes of endometrial cancer and associations with progression-free survival (PFS) were evaluated. METHODS: Molecular, clinical and PFS data were acquired from the Cancer Genome Atlas (TCGA) including classification into the integrative, somatic copy number alteration and transcript-based subtypes. The prevalence and prognostic value of the aggressive molecular subtypes (copy number variant [CNV]-high, cluster 4 or mitotic) were evaluated in Black and White patients...
April 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29602546/decreased-expression-of-tfap2b-in-endometrial-cancer-predicts-poor-prognosis-a-study-based-on-tcga-data
#17
Hongrong Wu, Jian Zhang
BACKGROUND: Transcription factor activator protein-2β (TFAP-2β) was previously reported to constituted promoter activity in endometrial carcinoma (EC). We evaluated the role of TFAP2B in ECs using publicly available data from The Cancer Genome Atlas (TCGA). METHODS: The relationship between clinical pathologic features and TFAP2B were analyzed with the Wilcoxon signed-rank test and logistic regression. Clinicopathologic characteristics associated with overall survival in TCGA patients using Cox regression and the Kaplan-Meier method...
March 28, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29602378/-melf-pattern-in-myometrial-infiltration-in-endometrioid-adenocarcinoma-of-the-endometrium-a-retrospective-study-of-70-cases
#18
Francisco Tresserra, María Ángela Pascual, Mireia Arenas, Claudia Blancafort, María Ángeles Martínez-Lanao, Ignacio Rodríguez, Rafa Fábregas
INTRODUCTION: Endometrioid adenocarcinoma of the endometrium (EAE) usually has a favorable prognosis. Recently, the MELF (microcystic, elongated and fragmented) pattern of myometrial infiltration has been described. It is associated with lymphovascular invasion and lymph node metastasis. Seventy cases of EAE were reviewed to identify the presence of MELF and its correlation with other prognostic factors. MATERIAL AND METHODS: Hysterectomies performed for EAE during a 5-year period were reviewed, searching for MELF pattern...
April 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29599905/affinity-purified-dna-based-mutation-profiles-of-endometriosis-related-ovarian-neoplasms-in-japanese-patients
#19
Masako Ishikawa, Kentaro Nakayama, Kohei Nakamura, Ruriko Ono, Kaori Sanuki, Hitomi Yamashita, Tomoka Ishibashi, Toshiko Minamoto, Kouji Iida, Sultana Razia, Noriyoshi Ishikawa, Satoru Kyo
Aim: Endometriosis-related ovarian neoplasms (ERONs) have recently attracted considerable attention; however, the prevalence and patterns of ARID1A and POLE mutations in ERONs have not been studied in detail. The aim of this study was to investigate not only the carcinogenesis of ERONs, but also the prognostic significance of several gene mutations in this cohort. We used DNA purified from only tumor epithelial cells, from which fibroblasts were removed, using a specific method we called "liquid microdissection"...
March 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29593653/identification-of-metabolomic-biomarkers-for-endometrial-cancer-and-its-recurrence-after-surgery-in-postmenopausal-women
#20
Yannick Audet-Delage, Lyne Villeneuve, Jean Grégoire, Marie Plante, Chantal Guillemette
Endometrial cancer (EC) is the most frequent gynecological cancer in developed countries. Most EC occurs after menopause and is diagnosed as endometrioid (type I) carcinomas, which exhibit a favorable prognosis. In contrast, non-endometrioid (type II) carcinomas such as serous tumors have a poor prognosis. Our goal was to identify novel blood-based markers associated with EC subtypes and recurrence after surgery in postmenopausal women. Using mass spectrometry-based untargeted metabolomics, we examined preoperative serum metabolites among control women ( n  = 18) and those with non-recurrent (NR) and recurrent (R) cases of type I endometrioid ( n  = 24) and type II serous ( n  = 12) carcinomas...
2018: Frontiers in Endocrinology
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