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Beril Anılanmert, Ibrahim Narın, Ibrahim Aydın, Munevver Acıkkol
In cases where pharmaceuticals and pharmaceutical candidates are involved in drug facilitated crimes (DFC), like organ theft, robbery, rape and suicides, the analysis of drug powders or solution residues found in crime scenes may give idea on what the victims have ingested. An easy and fast simultaneous determination of 7 drugs; GHB (γ-hydroxybutyrate), GBL (γ-butyrolactone), norketamine, ketamine, fenobarbital, fenitoin and thiopental which have the potential to be used in DFC was performed. The method required no sample preparation and has 12 minutes elution time with a good chromatographic separation...
January 2018: Pakistan Journal of Pharmaceutical Sciences
T A Voronina, M I Stoĭko, L N Nerobkova, G N Avakian, V A Kraĭneva
The administration of neurotoxin thiolactone homocysteine in rats with cobalt-induced epileptogenic focus in the sensomotor cortical region led to the development of secondary generalized convulsions and epileptic state. The pattern was analogous to the manifestation of convulsions in epileptic state in humans. Fenitoin (50 mg/kg) inhibited the development of convulsions, arrested the epileptic state, reduced the number and duration of the secondary generalized tonic--clonic attacks, decreased the behavioral manifestations (focal convulsions, lateral position etc...
January 2002: Eksperimental'naia i Klinicheskaia Farmakologiia
A L Guerrero, J A Pérez-Simón, A Cuñado, J Cacho, B Vidriales
We present a 41 woman who underwent an allogeneic bone marrow transplantation as a treatment for a multiple myeloma. After presenting graft-versus-host disease, hyperbilirubinemia, cyclosporine toxic levels, renal failure and peripheral schistocytosis, she developed complex partial seizures and bilateral hypodensity lesions in occipital lobes. Fulminant microangiopathy was diagnosed; though promptly treated with immunoglobulins and fenitoin, she died in few days. Necropsy showed diffuse thrombotic disease and a haematoma in left occipital lobe...
October 1998: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
A Belmont-Gomez, S Garza-Morales, J Ibarra-Puig, V López-Ugalde, A Morales-Garcia, J Kunhardt-Rasch
During pregnancy, there are several physiological changes that influence the kinetics of medication administrated during this time. These physiological changes are not reestablished immediately during delivery; so, its concentration in biologic fluids is different when is administered immediately after delivery, than several weeks after. The purpose in this work was to identify the changes of pharmacocinetics constants for fenitoin and carbamacepine, in epileptic patients. When the same dose is maintained, during different times of postpartum...
May 1997: Ginecología y Obstetricia de México
M Popović, K Daković-Svajcer, J Nerudova
The authors investigated the effects of the inductors (griseofulvin and fenitoin) and the inhibitors of the cytochrome P-450 (metronidazole, chloramphenicol and phenylbutazone), the effects of the drugs with the purine structure (aminophylline, xanthinol-nicotinate, pentoxiphylline, azathioprine, thioguanine, 6-mercaptopurine), and the effects of several pesticides (lindane, binapicrile, parathion) on some biochemical parameters of the rat liver. The following parameters were determined: viability of hepatocytes, the content of glutathione and cytochrome P-450, and the activity of xanthinoxidase and lipoperoxidase...
March 1992: Arhiv za Higijenu Rada i Toksikologiju
C Pintilie, D Florescu, S Tudor, C Alecu, M Macovei-Patriche, D Volanschi
No abstract text is available yet for this article.
1975: Neurologie et Psychiatrie
I Pascu, L Popoviciu, A Iazigian, M Gondaş, D Micu
No abstract text is available yet for this article.
October 1979: Revista de Medicină Internă, Neurologie, Psihiatrie, Neurochirurgie, Dermato-venerologie. Neurologie, Psihiatrie, Neurochirurgie
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